http://identifiers.org/biomodels.db/MODEL1310110037#_57f61aa9_5172_4964_87c0_b73ca9e6b07f
constant: false
is encoded by: hsa:27124
type: Species
is: Q15735
initial amount: NaN
name: INPP5J
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR UAGDP
fast: false
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
reversible: false
type: Reaction
modifier: MODEL1310110037#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.23
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: UDP-N-acetylglucosamine diphosphorylase

metaR ME1m
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: malic enzyme (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.38
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110037#
is described by: ECO:0000000
fast: false
reversible: false

metaM dopa e
is: CHEBI:59905
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial amount: NaN
has only substance units: false
name: dopaminium(1+)
constant: false
is: HMDB00073
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_cda81602_ecb6_4546_8087_a1dec060373d
is encoded by: hsa:1633
constant: false
is: P27707
name: DCK
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM 5mthf c
name: 5-Methyltetrahydrofolate
constant: false
boundary condition: false
is: C00440
has only substance units: false
initial amount: NaN
is: CHEBI:3729
is: SBO:0000247
initial concentration: 1.0
is: HMDB01396
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1

metaR NDPK5n
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
reactant: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
modifier: MODEL1310110037#
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110037#_51927887_bc86_499c_a7c0_56da074e6e0a
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q9BYZ2
name: LDHAL6B
constant: false
is encoded by: hsa:92483
has only substance units: false
type: Species
boundary condition: true

metaR ETOHt
name: ethanol reversible transport
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110037#_48c2f6dd_2d24_4d47_832c_042a5b0595e9
constant: false
name: AK5
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q9Y6K8
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:26289

metaM 4hglusa m
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB06556
initial amount: NaN
constant: false
is: SBO:0000247
name: L-4-hydroxyglutamic semialdehyde
is: CHEBI:27809
type: Species

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_b0f06482_cb6f_4a31_8fd5_faafa056d262
constant: false
is: Q96RV2
name: HAS3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3038
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_4d484c8c_fe39_4355_bfcd_9fd8190da66e
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI971036
name: _AI971036_1_x
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM gal c
is: CHEBI:0
is: HMDB00143
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: C00124
name: D-Galactose

http://identifiers.org/biomodels.db/MODEL1310110037#_0307fd29_4e50_4fa3_ac49_8672f965dede
boundary condition: true
constant: false
is: SBO:0000297
name: HEXA:HEXB
has part: P06865
is encoded by: hsa:3074
type: Species
has only substance units: false
is encoded by: hsa:3073
initial concentration: NaN
has part: P07686
initial amount: NaN

metaR METLEUex
is described by: ECO:0000269
reactant: MODEL1310110037#
is: SBO:0000185
modifier: MODEL1310110037#
reversible: false
name: Methionine/Leucine exchange (Met in)
fast: false
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (6520.1 and 8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310

http://identifiers.org/biomodels.db/MODEL1310110037#_7682a3eb_3a7d_4942_88b9_06d0dea9e94c
constant: false
boundary condition: true
is encoded by: hsa:10400
has only substance units: false
is: SBO:0000252
is: Q9UBM1
initial amount: NaN
type: Species
name: PEMT
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_244f795b_69d7_45a3_a87d_463dccb43437
constant: false
is: SBO:0000252
is encoded by: hsa:3284
name: HSD3B2
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: P26439
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_772c133e_ab85_4a26_9530_c7fb45ffe481
is encoded by: hsa:100
constant: false
name: ADA
type: Species
initial concentration: NaN
is: P00813
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM Sfglutth c
boundary condition: false
initial amount: NaN
is: HMDB01550
constant: false
type: Species
name: S-formylglutathionate(1-)
is: CHEBI:57688
is: SBO:0000247
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
has only substance units: false
initial concentration: 1.0

metaM xol7aone c
is: HMDB01993
constant: false
initial concentration: 1.0
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial amount: NaN
is: CHEBI:17899

metaM 3mop c
constant: false
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00491
is: CHEBI:28654
boundary condition: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

metaR r0570
product: MODEL1310110037#
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
is: SBO:0000176
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.3.3.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
reactant: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
reversible: true
fast: false

metaR CO2t
reactant: MODEL1310110037#
fast: false
product: MODEL1310110037#
is: SBO:0000185
type: Reaction
reversible: true
name: CO2 transporter via diffusion
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is described by: ECO:0000000

metaR 4MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110037#
is described by: ECO:0000134
reactant: MODEL1310110037#
name: Transport of 4-methyl-2-oxopentanoate
type: Reaction
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_475f5495_2228_422d_8a25_822da783627a
is: SBO:0000252
name: ENTPD3
is: O75355
is encoded by: hsa:956
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_23b0c070_755f_46a8_94e0_a7ba7a3dc3c7
is encoded by: hsa:23236
constant: false
has only substance units: false
name: PLCB1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR ASNPHELAT2tc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_0926d4b9_8c6c_41ee_b9ac_5ccb171ff59f
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:2678
name: GGT1
boundary condition: true
initial concentration: NaN
constant: false

metaM 3hmbcoa m
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: HMDB01356
is: CHEBI:57312
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR L LACt4r
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110037#
name: L-lactate reversible transport via sodium symport
kinetic law: MODEL1310110037#
reversible: true
product: MODEL1310110037#

metaM na1 r
is: CHEBI:29101
initial concentration: 1.0
type: Species
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
name: sodium(1+)
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00588

metaR LEUTA
is: SBO:0000176
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
name: leucine transaminase
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42

http://identifiers.org/biomodels.db/MODEL1310110037#_1530ccaa_a370_44c1_827c_942ce113cdee
name: _LOC728997_1_c
type: Species
is encoded by: hsa:LOC728997
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM dtdp m
is: SBO:0000247
name: dTDP
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
initial amount: NaN
is: CHEBI:58369
is: C00363
has only substance units: false

metaM dopa c
initial concentration: 1.0
is: CHEBI:59905
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
name: dopaminium(1+)
is: SBO:0000247
initial amount: NaN
is: HMDB00073
constant: false
boundary condition: false
type: Species

metaR BAAT2x
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000269
fast: false
modifier: MODEL1310110037#
name: bile acid Coenzyme A: amino acid N-acyltransferase
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110037#

metaM pan4p m
initial amount: NaN
name: pantetheine 4'-phosphate(2-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01416
is: CHEBI:47942
type: Species

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaM xylu L c
has only substance units: false
name: L-xylulose
type: Species
is: HMDB00751
initial amount: NaN
constant: false
is: CHEBI:17399
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_556e9798_8ad7_4423_aabc_724ab5445ea3
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: E9KL48
type: Species
is encoded by: hsa:2746
name: GLUD1
constant: false

metaM ins c
type: Species
name: Inosine
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17596
is: HMDB00195
has only substance units: false
is: C00294
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_1fb9394e_f16f_4700_aa99_c42c120a0bf7
type: Species
initial concentration: NaN
name: _U37519_1_c
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:U37519
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_85d461b6_acf8_4626_9b8a_1fe548854ae5
initial concentration: NaN
is encoded by: hsa:AI972237
boundary condition: true
name: _AI972237_1_c
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_fb132984_ae86_4cd2_93c6_65193f0d3885
constant: false
is encoded by: hsa:6582
initial amount: NaN
boundary condition: true
is: O15244
name: SLC22A2
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_33061336_f6cd_45c6_86f2_e9589126ee62
constant: false
is encoded by: hsa:8140
name: SLC7A5
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q8IV97
has only substance units: false
initial amount: NaN

metaM 3pg c
type: Species
is: SBO:0000247
name: 3-Phospho-D-glycerate
is: http://identifiers.org/pubchem.compound/3497
is: CHEBI:58272
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: C00197
is: HMDB00807

metaM glygn4 e
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
constant: false
notes: FORMULA: C18H31O16X CHARGE: 0
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00122
is: CHEBI:4167
initial amount: NaN

metaR TDCHOLAte
type: Reaction
name: bile acid intracellular transport
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: true

metaR SPHS1Pte
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is described by: ECO:0000000
reactant: MODEL1310110037#
fast: false
reversible: true
name: sphingosine-1-phosphate transport

metaR r0295
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
is described by: ECO:0000000
reactant: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:

metaM CE5120 m
initial amount: NaN
is: HMDB00127
boundary condition: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
type: Species
name: trans-2-cis-8-tetradecadienoyl-CoA
is: CHEBI:15748
has only substance units: false
constant: false
initial concentration: 1.0

metaR RE3421R
name: RE3421
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
product: MODEL1310110037#
fast: false
is: SBO:0000176
type: Reaction

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_ddf00e18_50bc_4e16_93dd_c30e738cb7b8
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AA576959
has only substance units: false
constant: false
name: _AA576959_1_c
boundary condition: true

metaR XYLTt
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110037#
type: Reaction
name: Xylitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110037#
product: MODEL1310110037#

metaM Lpipecol x
name: L-pipecolic acid
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
initial amount: NaN
is: CHEBI:30913
is: HMDB00716
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

metaR GCHOLAte
name: bile acid intracellular transport
is: SBO:0000185
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110037#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_ad73c56d_e5d8_400e_ac8f_ed5c9a5873b5
is: E7EPT3
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:501
constant: false
boundary condition: true
initial concentration: NaN
name: ALDH7A1
initial amount: NaN

metaR 5MTHFt
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_13604e68_e519_49d4_96a6_4154ccdff682
is encoded by: hsa:27068
name: PPA2
is: SBO:0000252
has only substance units: false
is: F8WDN9
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r1260
type: Reaction
name: EC:6.2.1.3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_132fbd5d_07f8_43cc_8513_5e3c2510887e
constant: false
is: Q53TV9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6120
name: RPE
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

metaM spc hs e
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/5311445
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
name: sphingosylphosphorylcholine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_0e6395bc_f9dc_4ba4_bf85_bb64f9652066
has only substance units: false
initial amount: NaN
boundary condition: true
name: COASY
type: Species
constant: false
is encoded by: hsa:80347
is: SBO:0000252
initial concentration: NaN
is: Q13057

metaR SGALSIDEtg
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#
name: sgalside hs intracellular transport
reversible: true

metaR O2ter
fast: false
name: O2 transport, endoplasmic reticulum
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
is: SBO:0000185

metaR r1673
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110037#
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_16d98048_f144_4df1_9669_cdc0cdd1b391
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5091
constant: false
type: Species
initial amount: NaN
name: PC
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_79236c11_944d_4a9e_910b_af8f5345b83a
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AW277253
constant: false
boundary condition: true
name: _AW277253_1_c

metaR r2309
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_d0706eb6_74da_4e10_bea2_8803b349d924
initial amount: NaN
name: NDUFA4
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4697
has only substance units: false
is: SBO:0000252
constant: false
is: O00483

metaM CE5854 e
initial amount: NaN
is: CHEBI:27485
initial concentration: 1.0
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
name: gama-CEHC-glucuronide
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02710
has only substance units: false
type: Species

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_3d155023_ec23_42cb_a9d3_55fdcd46f315
initial amount: NaN
is: SBO:0000252
is: Q9NYQ3
initial concentration: NaN
boundary condition: true
type: Species
name: HAO2
is encoded by: hsa:51179
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_7f1ac87a_a1c4_4069_b02f_91fa28d0a39a
type: Species
initial amount: NaN
boundary condition: true
name: NDUFA9
constant: false
is: Q16795
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4704
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_1ae4bc45_464e_414e_9e0f_ddaba77999b3
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:5331
initial amount: NaN
is: G5E960
name: PLCB3
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_815ce56c_d9eb_4c53_9083_f7829b48187f
has part: B2RAU6
initial amount: NaN
is encoded by: hsa:5279
constant: false
type: Species
is encoded by: hsa:5277
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:9091
has part: P57054
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:51227
boundary condition: true
has only substance units: false

metaR r0360
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
product: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_a57fb0e0_73fc_4f91_9d5f_da31f4246e41
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: O43772
is encoded by: hsa:788
name: SLC25A20
boundary condition: true

metaM prostgi2 e
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
is: CHEBI:57403
is: HMDB01335
initial concentration: 1.0
type: Species
name: prostaglandin I2(1-)

metaR RDH1a
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
type: Reaction
kinetic law: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.300
is: SBO:0000176
fast: false
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.105
modifier: MODEL1310110037#
is described by: ECO:0000269
name: retinol dehydrogenase (all-trans,NADPH)

metaR r1156
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is: SBO:0000176
kinetic law: MODEL1310110037#
reversible: true

metaR r2399
reversible: false
product: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

http://identifiers.org/biomodels.db/MODEL1310110037#_06ef96dd_d2dc_4076_b6e7_810907c6fe67
type: Species
is: SBO:0000252
name: CMA1
is: Q4FEB3
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1215
has only substance units: false
boundary condition: true

metaR r2511
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
is: SBO:0000185
reversible: true
product: MODEL1310110037#
name: Utilized transport
fast: false

metaR CYTK3n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,CTP),nuclear
modifier: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110037#
is: SBO:0000176
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_fb6c4095_cb22_408c_8898_89cba0e8987c
has only substance units: false
name: _AI631997_1_m
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI631997
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR r1527
modifier: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.1
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_100493c7_b277_4908_8cc1_b43a7436f70c
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:10327
boundary condition: true
name: AKR1A1
initial concentration: NaN
constant: false

metaM succ x
has only substance units: false
initial concentration: 1.0
name: Succinate
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
is: C00042
is: HMDB00254
is: CHEBI:30031

metaR r0575
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is: SBO:0000176
reversible: true
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
fast: false
is described by: ECO:0000000
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.1.48
type: Reaction
reactant: MODEL1310110037#

metaR AKR1C41
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
fast: false

metaR SUCCTD
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_577c5a18_8a21_4b60_af08_7602fe9c5cda
name: MTMR2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:8898
is: A6NN98
type: Species
constant: false
has only substance units: false

metaM duri n
is: HMDB00012
name: 2'-deoxyuridine
has only substance units: false
constant: false
is: CHEBI:16450
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN

metaM 3mgcoa m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57346
boundary condition: false
is: HMDB01057
name: trans-3-methylglutaconyl-CoA(5-)
constant: false

metaM csn c
is: CHEBI:16040
type: Species
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: HMDB00630
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: cytosine
constant: false
has only substance units: false

metaR r1885
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
reversible: false
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000185

metaR r1671
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
reversible: true

metaM 5mthf e
name: 5-Methyltetrahydrofolate
is: C00440
constant: false
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
has only substance units: false
boundary condition: false
is: CHEBI:3729
type: Species
is: HMDB01396
is: SBO:0000247
initial concentration: 1.0

metaR r2510
name: Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
fast: false
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_8965baff_3afa_4314_966b_2f1b08f5860b
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q5SYN6
initial concentration: NaN
type: Species
is encoded by: hsa:6581
constant: false
name: SLC22A3
has only substance units: false

metaR r0974
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
name: Active transport
reversible: true
type: Reaction
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_b6a4d30c_40fb_40c9_8694_1acf6035b212
is encoded by: hsa:8310
is: O15254
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ACOX3
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_4d326a3f_306a_410b_9d70_1a9dfbede07f
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: GPD1
is: F8W1L5
boundary condition: true
is encoded by: hsa:2819
constant: false
type: Species
has only substance units: false

metaM gal e
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
name: D-Galactose
has only substance units: false
is: SBO:0000247
constant: false
is: C00124
is: CHEBI:0
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_34c2ea73_13b7_44e0_b97c_172d93f80281
has only substance units: false
boundary condition: true
is: Q05932
name: FPGS
initial concentration: NaN
type: Species
is encoded by: hsa:2356
constant: false
initial amount: NaN
is: SBO:0000252

metaM glyald c
is: HMDB01051
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
name: D-Glyceraldehyde
initial concentration: 1.0
type: Species
is: CHEBI:17378
is: C00577

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR r1884
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110037#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
reactant: MODEL1310110037#

metaR r1670
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR GTMLTe
reversible: false
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110037#
is: SBO:0000185
fast: false
name: g-glutamyltransferase (e)
is described by: ECO:0000269
product: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854

metaR G6PDA
modifier: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (132789.1) or (10007.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.5.99.6 Confidence Level: 4 AUTHORS: PMID:9714720 NOTES:Previously EC 5.3.1.10
kinetic law: MODEL1310110037#
name: glucosamine-6-phosphate deaminase
is: SBO:0000176
product: MODEL1310110037#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.99.6
type: Reaction

metaR NOt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
reactant: MODEL1310110037#
name: NO transport (diffusion)
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM prostgi2 c
is: SBO:0000247
is: CHEBI:57403
name: prostaglandin I2(1-)
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial concentration: 1.0
is: HMDB01335
boundary condition: false
constant: false

metaM dolmanp U r
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
constant: false
is: CHEBI:15809
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human uterine homolog
is: SBO:0000247

metaR r1154
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: EC:1.2.7.2
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
product: MODEL1310110037#

metaR r2308
is: SBO:0000185
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
reversible: true
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000

metaR r0973
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000185
name: Facilitated diffusion
type: Reaction
fast: false
reactant: MODEL1310110037#

metaM lnlncgcoa c
boundary condition: false
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB06368
initial amount: NaN
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
is: CHEBI:57363

http://identifiers.org/biomodels.db/MODEL1310110037#_ad0809bc_6b23_4f92_a8ee_a5f2bd7387fb
initial concentration: NaN
type: Species
is: Q9ULD0
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: OGDHL
is encoded by: hsa:55753
boundary condition: true

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR DURIt
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
name: deoxyuridine transport via diffusion
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110037#

metaM HC02121 c
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: CHEBI:58758
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
initial amount: NaN
initial concentration: 1.0
name: S-(hydroxymethyl)glutathione(1-)

metaM dadp c
type: Species
has only substance units: false
is: C00206
initial amount: NaN
name: dADP
constant: false
is: SBO:0000247
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_b2385a22_1d1a_4964_a83c_aa15573006a7
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:5860
name: QDPR
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P09417
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_97532de6_5f13_48a8_81f9_6988336f50c4
name: ENPP3
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is: Q308M7
is encoded by: hsa:5169
constant: false
is: SBO:0000252

metaM pail45p hs m
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28910
has only substance units: false
type: Species
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_b9e13cf9_c728_4bb8_9b76_2f06d8dd4062
initial amount: NaN
is encoded by: hsa:30
is: Q96CA6
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: ACAA1
constant: false

metaR r2516
product: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
reactant: MODEL1310110037#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM HC02204 e
initial concentration: 1.0
name: prostaglandin-b1
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
type: Species
constant: false
is: CHEBI:27624
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_44f843f7_8347_4566_a2b3_503a7466d197
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI924226
has only substance units: false
constant: false
type: Species
boundary condition: true
name: _AI924226_1_m
initial amount: NaN

metaM dtdp c
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00363
is: HMDB01274
type: Species
is: CHEBI:58369
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_f83f6cda_f7eb_4f75_abd7_c0d18bdbbcee
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: NOS3
is encoded by: hsa:4846
is: A0S0A7
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_822b706b_f102_4f5e_ba9d_b19b4a0d6d1d
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_1beeaa8d_3c2a_462a_ac41_ba31238015d9
type: Species
initial amount: NaN
is encoded by: hsa:8659
is: P30038
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: ALDH4A1

metaR ACCOALm
kinetic law: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
product: MODEL1310110037#
modifier: MODEL1310110037#
name: acetate-CoA ligase (AMP-forming)
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176

metaR PAIL4P HStn
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110037#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)

metaM drib c
initial concentration: 1.0
is: CHEBI:28816
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
constant: false
is: HMDB03224
initial amount: NaN
name: 2-deoxy-D-ribose
has only substance units: false

metaM accoa m
type: Species
constant: false
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
name: Acetyl-CoA
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57288
is: SBO:0000247
is: C00024

metaR ARACHCPT1
fast: false
modifier: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110037#
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_7bb1429c_1289_4306_89e0_f3e4562b0152
is encoded by: hsa:8034
is: P16260
type: Species
constant: false
initial amount: NaN
name: SLC25A16
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM coa n
is: HMDB01423
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
has only substance units: false
is: CHEBI:57287
boundary condition: false
name: coenzyme A(4-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_79d171d3_349f_43d0_80de_6197b583c390
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM lnlncgcoa r
initial amount: NaN
is: SBO:0000247
is: HMDB06368
is: CHEBI:57363
has only substance units: false
type: Species
constant: false
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

http://identifiers.org/biomodels.db/MODEL1310110037#_80d8bf22_e51f_4430_a9b6_55b53ab70a58
has only substance units: false
is: SBO:0000252
is encoded by: hsa:501
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: ALDH7A1
constant: false
is: E7EPT3

metaR PE HStm
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: phosphatidylethanolamine scramblase
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM csn e
boundary condition: false
constant: false
is: CHEBI:16040
has only substance units: false
name: cytosine
type: Species
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial concentration: 1.0
initial amount: NaN
is: HMDB00630
is: SBO:0000247

metaM dag hs r
name: diglyceride
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
initial concentration: 1.0
is: CHEBI:18035

metaM pail45p hs n
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: phosphatidylinositol 4,5-bisphosphate
type: Species
has only substance units: false

metaR LEUt5m
kinetic law: MODEL1310110037#
is: SBO:0000185
reversible: true
name: leucine mitochondrial transport
product: MODEL1310110037#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110037#
is described by: ECO:0000000

metaR r0426
is: SBO:0000176
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.5.1.34
reversible: true
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is described by: ECO:0000000
type: Reaction

metaM nadp c
is: CHEBI:58349
type: Species
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
constant: false
is: HMDB00217
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM so3 c
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: C00094
has only substance units: false
is: SBO:0000247
is: CHEBI:17137
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00240
type: Species
name: Sulfite

metaR CERK
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.138
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110037#
name: Ceramide kinase
reversible: false
notes: GENE_ASSOCIATION: (64781.1) or (64781.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.7.1.138 Confidence Level: 4 AUTHORS: PMID:11956206 NOTES:NJ
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_274d26d9_7721_4eac_a664_471a664b7326
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: IDH2
is: P48735
is encoded by: hsa:3418
constant: false

metaR r2419
type: Reaction
reversible: true
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_c3e2da78_e8de_4489_acb6_e6752a54fb1b
is: SBO:0000297
type: Species
constant: false
initial concentration: NaN
name: SUCLG2:SUCLG1
is encoded by: hsa:8802
has part: P53597
boundary condition: true
has part: Q96I99
has only substance units: false
initial amount: NaN
is encoded by: hsa:8801

metaR ARACHCPT2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
reversible: false
name: carnitine transferase
type: Reaction
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
product: MODEL1310110037#

metaM dgtp e
constant: false
is: HMDB01440
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16497
type: Species
name: dGTP
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR SGALSIDEtl
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
name: sgalside hs intracellular transport
reactant: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false

metaR INSTt4
name: inositol transport via sodium symport
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
fast: false
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#

metaM accoa n
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57288
type: Species
constant: false
is: HMDB01206
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)

metaM pi c
boundary condition: false
notes: FORMULA: HO4P CHARGE: -2
has only substance units: false
name: hydrogenphosphate
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:43474
initial concentration: 1.0
constant: false
is: HMDB00973
is: C00009

metaM xol7aone m
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01993
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_8e7de474_979c_4b4c_9a94_0608ed7f1564
initial amount: NaN
name: _BF195998_1_x
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:BF195998

http://identifiers.org/biomodels.db/MODEL1310110037#_6127eb90_6e43_4451_88fd_eb8f9b949b8f
is: SBO:0000252
type: Species
is: Q86VV3
initial amount: NaN
constant: false
name: ENTPD1
is encoded by: hsa:953
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r0425
reversible: true
name: EC:1.1.1.42
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.17.1.4
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaM paps c
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01134
is: CHEBI:58339
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
boundary condition: false
constant: false

metaR r0579
fast: false
product: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.19
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_c596fa64_ae6d_467c_8127_7a49f18f682b
is encoded by: hsa:766
boundary condition: true
is: P43166
name: CA7
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_ec2488a8_3a93_4fc1_b20b_f5325923cd5c
initial amount: NaN
constant: false
is encoded by: hsa:AI620219
boundary condition: true
type: Species
name: _AI620219_1_c
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM dtdp e
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
is: CHEBI:58369
constant: false
is: SBO:0000247
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial amount: NaN

metaR DGCHOLte
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000000
name: bile acid intracellular transport
product: MODEL1310110037#
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

http://identifiers.org/biomodels.db/MODEL1310110037#_b46adf0a_ff4a_49a3_b602_5f2c0d3f7b99
is encoded by: hsa:6576
initial concentration: NaN
boundary condition: true
has only substance units: false
is: D9HTE9
name: SLC25A1
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR ALCD2yf
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
product: MODEL1310110037#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
type: Reaction
kinetic law: MODEL1310110037#

metaM 3hbcoa m
is: CHEBI:57316
is: HMDB01166
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: (S)-3-hydroxybutanoyl-CoA(4-)
boundary condition: false
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144

metaM HC02204 c
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: CHEBI:27624
name: prostaglandin-b1
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM hpyr c
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01352
name: 3-hydroxypyruvate
is: CHEBI:17180
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
constant: false

metaR r2514
fast: false
reactant: MODEL1310110037#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
kinetic law: MODEL1310110037#
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_d4bdc547_6f5a_429f_bc17_5bebafdbf6f7
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4709
is: Q6IB80
boundary condition: true
type: Species
name: NDUFB3

metaR r1881
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110037#
name: Y+LAT2 Utilized transport
product: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_6d927b4f_dc33_4adf_8ced_194f1f7e2d0d
is: SBO:0000252
is encoded by: hsa:54872
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: PIGG
initial concentration: NaN
is: Q8NCI4

metaM so4 l
initial concentration: 1.0
is: CHEBI:16189
name: sulfate
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01448
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

metaR DINt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110037#
name: deoxyinosine transport via diffusion
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true

metaR PCHOLPm hs
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110037#
fast: false
name: choline phosphatase
kinetic law: MODEL1310110037#
is described by: ECO:0000269
modifier: MODEL1310110037#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_159e155e_1e92_4fb6_85a5_c1c296fa6ff4
has only substance units: false
initial amount: NaN
is: G3XAJ0
name: ACAD10
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80724
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_44d41f75_4faa_48ea_a973_bae5ee6a676a
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9091
name: PIGQ
boundary condition: true
is: Q9BRB3
type: Species
constant: false
is: SBO:0000252

metaR PAPStg
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
reversible: true
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110037#
name: 3'-Phosphoadenylyl sufate Golgi transport

metaM dgtp c
boundary condition: false
type: Species
has only substance units: false
name: dGTP
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
is: C00286
is: SBO:0000247
is: CHEBI:16497
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_cf743d49_4be9_4c1d_be21_7f7b8779f092
name: GPX3
constant: false
is encoded by: hsa:2878
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P22352
is: SBO:0000252
type: Species
initial amount: NaN

metaR SGPL12r
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.1.2.27
modifier: MODEL1310110037#
fast: false
name: Sphingosine-1-phosphate lyase
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reversible: false
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_87d88e45_848e_4791_9dea_3f09bff14845
initial amount: NaN
type: Species
is: SBO:0000252
is: P48507
constant: false
name: GCLM
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2730

metaM so4 m
name: sulfate
has only substance units: false
initial amount: NaN
is: CHEBI:16189
constant: false
is: SBO:0000247
is: HMDB01448
boundary condition: false
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0

metaR r0142
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
kinetic law: MODEL1310110037#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
modifier: MODEL1310110037#
reversible: false
product: MODEL1310110037#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR FAOXC80
kinetic law: MODEL1310110037#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110037#
name: Beta oxidation of med/long chain fatty acid

metaR DAGK hs
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.107
is: SBO:0000176
reversible: true
name: Diacylglycerol phosphate kinase (homo sapiens)
kinetic law: MODEL1310110037#
product: MODEL1310110037#

metaM galside hs g
has only substance units: false
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:12947

http://identifiers.org/biomodels.db/MODEL1310110037#_17bcb47e_352a_4d6d_b73e_d2f9ffe16129
type: Species
has only substance units: false
name: ELOVL1
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:64834
initial concentration: NaN
is: Q9BW60
boundary condition: true

metaM coa m
type: Species
has only substance units: false
constant: false
is: SBO:0000247
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
is: HMDB01423
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57287

http://identifiers.org/biomodels.db/MODEL1310110037#_d4115bf7_b697_4a76_a4ef_ddb642b32638
is: SBO:0000252
name: GGT7
initial amount: NaN
initial concentration: NaN
is: A0PJJ9
has only substance units: false
type: Species
is encoded by: hsa:2686
boundary condition: true
constant: false

metaM ptrc c
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:326268
name: Putrescine
is: HMDB01414
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: C00134

http://identifiers.org/biomodels.db/MODEL1310110037#_429e9070_79e0_4903_a3cb_ebcdcfa643b6
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:2348
constant: false
has only substance units: false
name: FOLR1

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaR FMNAT
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110037#
reversible: false
is: SBO:0000176
modifier: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
name: FMN adenylyltransferase
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.7.2

http://identifiers.org/biomodels.db/MODEL1310110037#_1326307c_1652_4ae6_afba_2e1169423052
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P19404
type: Species
name: NDUFV2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4729
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_f95da14b_12f0_4890_b8d2_f0fce5fa09ed
name: GLRX
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: P35754
boundary condition: true
is encoded by: hsa:2745
has only substance units: false

metaM atp c
is: CHEBI:30616
boundary condition: false
type: Species
name: ATP(4-)
is: SBO:0000247
has only substance units: false
is: HMDB00538
is: C00002
constant: false
initial concentration: 1.0
initial amount: NaN

metaM nh4 m
has only substance units: false
name: Ammonium
constant: false
boundary condition: false
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
is: SBO:0000247
is: CHEBI:28938
initial amount: NaN
is: C01342
initial concentration: 1.0

metaR HACD1m
reversible: true
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000134
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)

metaR r1734
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false

metaM ins e
name: Inosine
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: CHEBI:17596
initial amount: NaN
boundary condition: false
is: HMDB00195
has only substance units: false
is: SBO:0000247
constant: false
is: C00294

http://identifiers.org/biomodels.db/MODEL1310110037#_b68ffd82_ceeb_48ee_b981_e51d1f7361af
name: SLC2A1
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P11166
initial concentration: NaN
is encoded by: hsa:6513
has only substance units: false
constant: false

metaM coa r
has only substance units: false
initial amount: NaN
type: Species
constant: false
boundary condition: false
name: Coenzyme A
is: SBO:0000247
is: CHEBI:57287
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
is: HMDB01423
is: C00010

metaM dag hs n
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:18035
name: diglyceride

metaR r0423
modifier: MODEL1310110037#
is described by: ECO:0000000
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reversible: true
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_c92f7ddc_44f8_4806_a45d_cf95d6dce19d
is: P43005
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:6505
has only substance units: false
name: SLC1A1

metaM pectingchol e
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C2561H3553NO2541 CHARGE: 0
initial concentration: 1.0
is: HMDB03402
is: SBO:0000247
has only substance units: false
boundary condition: false
name: pectin-glycocholate complex

metaR r2519
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
fast: false
reversible: true
product: MODEL1310110037#
type: Reaction
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110037#_d5b0d22b_3a61_4846_8c53_9921071492f8
initial concentration: NaN
initial amount: NaN
is: Q63HM1
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:125061
name: AFMID
has only substance units: false

metaM nh4 n
is: HMDB00051
initial concentration: 1.0
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
is: CHEBI:28938
name: ammonium
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaR 3MOX4HOXPGALDOX
modifier: MODEL1310110037#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_fce4ceb3_0f86_4e47_9db8_d4dd57071bcf
is: SBO:0000252
initial amount: NaN
name: CPT1B
is encoded by: hsa:1375
has only substance units: false
is: Q92523
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaM lnlncgcoa m
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
is: HMDB06368
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_ea1cd21e_026d_4ba2_a41e_da942af950c3
is: P00390
type: Species
constant: false
boundary condition: true
name: GSR
initial amount: NaN
has only substance units: false
is encoded by: hsa:2936
initial concentration: NaN
is: SBO:0000252

metaR r0422
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
modifier: MODEL1310110037#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaM na1 e
initial concentration: 1.0
type: Species
notes: FORMULA: Na CHARGE: 1
initial amount: NaN
boundary condition: false
name: Sodium
is: CHEBI:4541
constant: false
is: HMDB00588
is: C01330
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_4d8a89e1_7adc_4fb1_97ae_561699fdab3c
initial amount: NaN
constant: false
is encoded by: hsa:AA977580
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _AA977580_1_c
boundary condition: true
type: Species

metaM paps g
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
type: Species
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58339
boundary condition: false
is: HMDB01134

metaR PCm
modifier: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.1
reversible: false
product: MODEL1310110037#
type: Reaction
fast: false
kinetic law: MODEL1310110037#
name: pyruvate carboxylase
is described by: ECO:0000269

metaR MMSAD1m
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.27
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
reversible: false
is: SBO:0000176
name: methylmalonate-semialdehyde dehydrogenase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_0173fb8a_d1c9_4623_9048_4102f71fa022
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:29925
name: GMPPB
boundary condition: true
has only substance units: false
type: Species
is: Q9Y5P6

metaR ACACt2
product: MODEL1310110037#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is: SBO:0000185
modifier: MODEL1310110037#
is described by: ECO:0000269
name: acetoacetate transport via proton symport
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaM btcoa m
is: CHEBI:57371
boundary condition: false
is: C00136
name: Butanoyl-CoA
has only substance units: false
type: Species
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: HMDB01088
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR r0647
name: Spontaneous reaction
fast: false
product: MODEL1310110037#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#

metaM duri e
name: Deoxyuridine
is: CHEBI:16450
is: C00526
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00012
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_da55bd4b_2401_4d32_bae3_9455ecd80ca6
name: COX6C
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1345
initial concentration: NaN
has only substance units: false
is: P09669

metaM mercplaccys e
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB06512
type: Species
constant: false

metaM galside hs l
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0

metaM glyclt c
is: SBO:0000247
name: glycolate
boundary condition: false
initial amount: NaN
is: CHEBI:29805
initial concentration: 1.0
is: HMDB00115
type: Species
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
has only substance units: false
constant: false

metaR FUM
is version of: http://identifiers.org/ec-code/4.2.1.2
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110037#
reversible: true
product: MODEL1310110037#
name: fumarase

metaR P5CDm
fast: false
modifier: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is described by: ECO:0000269
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

metaM occoa m
is: C01944
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01070
constant: false
boundary condition: false
type: Species
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
name: Octanoyl-CoA (n-C8:0CoA)

metaR HACD9m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110037#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
fast: false
modifier: MODEL1310110037#
reversible: true
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134

metaR AMY1e
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
name: alpha-amylase, extracellular (strch1 -> strch2)
type: Reaction
kinetic law: MODEL1310110037#
fast: false

metaM 5adtststerone r
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB02961
boundary condition: false
has only substance units: false
is: CHEBI:16330

http://identifiers.org/biomodels.db/MODEL1310110037#_6a6ec5e4_0eaf_4b08_8cf1_342a134e26c0
initial concentration: NaN
type: Species
name: PIGU
is: Q9H490
has only substance units: false
is: SBO:0000252
is encoded by: hsa:128869
boundary condition: true
constant: false
initial amount: NaN

metaM pi e
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:43474
is: SBO:0000247
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
constant: false
is: C00009
is: HMDB00973
initial concentration: 1.0

metaR PItx
product: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Phosphate transporter, peroxisome
kinetic law: MODEL1310110037#
type: Reaction

metaR r1678
product: MODEL1310110037#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Y+LAT2 Utilized transport
reversible: false
fast: false

metaM glyb e
initial amount: NaN
is: HMDB00043
name: glycine betaine
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:17750
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaR r2310
type: Reaction
is: SBO:0000185
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000000

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR r0644
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
fast: false
is: SBO:0000176

metaR ASNtN1
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
modifier: MODEL1310110037#
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_ec8411e9_84f1_49ad_a2ac_00b50d9ccf40
is encoded by: hsa:763
constant: false
has only substance units: false
name: CA5A
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is: P35218

http://identifiers.org/biomodels.db/MODEL1310110037#_c7d0b6cf_9287_48e8_a5f6_c58ee83a6379
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: E5KNH5
boundary condition: true
is encoded by: hsa:4723
is: SBO:0000252
name: NDUFV1
constant: false

metaR BHBtm
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true

metaR UGT1A10r
is described by: ECO:0000134
kinetic law: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.17
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is: SBO:0000176
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal

metaM fdp c
is: http://identifiers.org/pubchem.compound/3647
initial amount: NaN
boundary condition: false
is: C00354
is: CHEBI:16905
constant: false
is: HMDB01058
initial concentration: 1.0
name: D-Fructose 1,6-bisphosphate
has only substance units: false
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: SBO:0000247

metaM glyclt x
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
has only substance units: false
is: HMDB00115
type: Species
boundary condition: false
is: CHEBI:29805
constant: false
name: glycolate
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR RE0830C
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110037#
fast: false
name: RE0830
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110037#

metaM so4 c
is: SBO:0000247
boundary condition: false
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
initial amount: NaN
type: Species
is: HMDB01448
has only substance units: false
is: CHEBI:16189
initial concentration: 1.0

metaM coa x
initial concentration: 1.0
name: Coenzyme A
is: SBO:0000247
has only substance units: false
is: CHEBI:57287
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
is: HMDB01423
is: C00010
constant: false
type: Species

metaR DNDPt29m
name: dCDP transport via dADP antiport
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000185
fast: false

metaR GUAPRT
name: guanine phosphoribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.8
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
fast: false
reactant: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_60d335fe_72ac_4372_9734_759d7cdb8989
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:728637
constant: false
type: Species
name: _728637_1_c
has only substance units: false
is: SBO:0000252

metaR RE2541E
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: RE2541
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
is: SBO:0000176

metaM kynate c
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: HMDB00715
constant: false
name: kynurenate
type: Species
initial concentration: 1.0
is: CHEBI:58454
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_83c8bceb_7b0f_40d9_b2b3_160ce592716c
is: B2RAU6
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:9091
name: PIGQ
type: Species
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_efca92af_fc49_4f6f_b765_4b73dff6985a
has only substance units: false
is encoded by: hsa:2954
name: GSTZ1
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaR r1381
kinetic law: MODEL1310110037#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reactant: MODEL1310110037#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110037#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaM Rtotal2 c
is: CHEBI:60377
is: SBO:0000247
is: HMDB00095
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: C00055
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: R total 2 position

http://identifiers.org/biomodels.db/MODEL1310110037#_514e406e_c930_4372_b8cf_44666d62636b
is encoded by: hsa:230
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: P09972
constant: false
name: ALDOC

metaM CE1926 e
is: SBO:0000247
boundary condition: false
is: CHEBI:15748
has only substance units: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: HMDB00127
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: gama-carboxyethyl-hydroxychroman

metaM bildglcur e
initial amount: NaN
is: HMDB03325
is: SBO:0000247
constant: false
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
has only substance units: false
boundary condition: false
type: Species

metaM dump c
name: dUMP
is: C00365
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
is: CHEBI:246422
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01409
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_1d563dd6_e84f_43e0_a129_fe2f8a61774a
is encoded by: hsa:275
type: Species
has part: P48728
has part: P23378
is encoded by: hsa:2653
is encoded by: hsa:2731
has part: P23434
boundary condition: true
initial concentration: NaN
name: DLD:GCSH:GLDC:AMT
constant: false
initial amount: NaN
is: SBO:0000297
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_811e4ee9_b591_4d17_9cc7_2a263564fd4d
boundary condition: true
is: O75874
constant: false
is encoded by: hsa:3417
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: IDH1
is: SBO:0000252

metaR RE2799C
fast: false
name: RE2799
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#

metaR ACGPID
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is described by: ECO:0000269
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
modifier: MODEL1310110037#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.89

metaM duri c
name: Deoxyuridine
has only substance units: false
constant: false
is: HMDB00012
is: CHEBI:16450
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
is: C00526
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_f5f496e3_f02d_43ad_9c34_b821959bd83b
is: SBO:0000297
type: Species
initial amount: NaN
name: HADHA:HADHB
has part: E9KL44
initial concentration: NaN
has part: P55084
constant: false
boundary condition: true
is encoded by: hsa:3030
has only substance units: false
is encoded by: hsa:3032

metaR RE3568C
reversible: true
kinetic law: MODEL1310110037#
fast: false
name: RE3568
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_8f86e8a8_c722_497d_b68e_253ef69785f8
initial amount: NaN
initial concentration: NaN
is: Q16348
is: SBO:0000252
is encoded by: hsa:6565
has only substance units: false
name: SLC15A2
constant: false
type: Species
boundary condition: true

metaM crn r
is: HMDB00062
initial amount: NaN
type: Species
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: (R)-carnitine
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_bfabbbe9_c09b_434b_bbe5_a3e5bf4226c2
has only substance units: false
is encoded by: hsa:5161
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: PDHA2
is: P29803
initial concentration: NaN

metaR TCHOLAte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
product: MODEL1310110037#
name: bile acid intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction

metaR r0139
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110037#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
modifier: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_00a84290_3c9e_4814_a74e_0859fe85b7d7
name: SLC38A1
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:81539
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9H2H9
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_3269d3e6_f695_4f32_81ee_01c0bbbba4aa
constant: false
type: Species
name: DGKB
is encoded by: hsa:1607
is: Q9Y6T7
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR LEUKTRD4t
kinetic law: MODEL1310110037#
is described by: ECO:0000269
reversible: true
name: leukotriene D4 transport
product: MODEL1310110037#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:

metaR r1259
name: EC:6.2.1.3
fast: false
is described by: ECO:0000000
product: MODEL1310110037#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_24ca2d45_a118_4aa9_b5ba_74942b9b2991
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5052
initial amount: NaN
boundary condition: true
name: PRDX1
has only substance units: false

metaM pmtcoa c
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
type: Species
has only substance units: false
is: HMDB01338
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_3e3633fe_a901_4b4b_8779_3977fb0cd503
has only substance units: false
is encoded by: hsa:9152
type: Species
name: SLC6A5
is: Q9Y345
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r1380
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reactant: MODEL1310110037#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: true
product: MODEL1310110037#

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_ebd776e5_e3c8_4f12_a0a8_4cee2d68d98f
is encoded by: hsa:9374
name: PPT2
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: Q9UMR5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_8c3002dd_4448_4ac0_af95_1fca2487d531
has only substance units: false
initial amount: NaN
type: Species
name: AK4
initial concentration: NaN
constant: false
is: P27144
boundary condition: true
is encoded by: hsa:205
is: SBO:0000252

metaR 13DAMPPOX
reversible: false
is described by: ECO:0000212
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.21
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)

metaR r0642
reversible: true
is: SBO:0000176
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
fast: false

metaM so4 e
type: Species
is: HMDB01448
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:16189
constant: false
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate

metaM lnlccrn c
is: SBO:0000247
name: Linoleyl carnitine
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06469

metaM ibcoa m
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
is: CHEBI:57338
is: HMDB01243
type: Species
initial concentration: 1.0
name: isobutyryl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110037#_8f19ec81_506b_4129_bc96_bcd5c5cc43f1
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P33897
is encoded by: hsa:215
constant: false
initial amount: NaN
name: ABCD1
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_a084f97e_45e3_4e41_b914_d7d1dee2e411
is: P30084
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ECHS1
initial amount: NaN
is encoded by: hsa:1892
type: Species
constant: false

metaM 5adtststerone e
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: SBO:0000247
type: Species
boundary condition: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
is: CHEBI:16330
initial concentration: 1.0
constant: false
has only substance units: false

metaR GLYt7 311 r
is: SBO:0000185
name: glycine reversible transport via sodium and chloride symport (3:1:1)
type: Reaction
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000006
modifier: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaM HC01672 c
boundary condition: false
is: CHEBI:37666
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
name: Acetyl adenylate

http://identifiers.org/biomodels.db/MODEL1310110037#_9464bdf1_cf16_4f21_841d_d48591831a90
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:29988
initial amount: NaN
is: SBO:0000252
name: SLC2A8
constant: false
is: Q9NY64

metaR G3PD1
type: Reaction
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is version of: http://identifiers.org/ec-code/1.1.1.8
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110037#
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
name: glycerol-3-phosphate dehydrogenase (NAD)
reversible: true
kinetic law: MODEL1310110037#

metaR FUMAC
is described by: ECO:0000269
fast: false
reactant: MODEL1310110037#
type: Reaction
name: fumarylacetoacetase
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.7.1.2
kinetic law: MODEL1310110037#
is: SBO:0000176
reversible: false
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_b65d358d_e755_4e86_838e_369b8585f72c
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: HEXB
is: P07686
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:3074

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaR ARACHCRNt
reversible: false
kinetic law: MODEL1310110037#
type: Reaction
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaM bildglcur c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58471
type: Species
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
is: SBO:0000247
constant: false
has only substance units: false

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaR ACt2r
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
type: Reaction
reactant: MODEL1310110037#
fast: false
reversible: true
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
name: acetate reversible transport via proton symport
is: SBO:0000185

metaR r2390
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110037#
reversible: false
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false

metaR CDPDAGtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: intracellular transport
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000

metaM adrn c
is: HMDB02226
initial concentration: 1.0
is: CHEBI:53487
boundary condition: false
name: adrenic acid
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_eb6521ba_5d0d_4f55_be4c_4c3f968cf1ca
name: GAPDHS
type: Species
is encoded by: hsa:26330
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: O14556

http://identifiers.org/biomodels.db/MODEL1310110037#_aa05fefc_e467_40e9_814d_13b20de34306
type: Species
name: PLCD3
boundary condition: true
has only substance units: false
is encoded by: hsa:113026
initial amount: NaN
is: Q8N3E9
initial concentration: NaN
is: SBO:0000252
constant: false

metaM tdchola c
is: CHEBI:9407
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: HMDB00951
has only substance units: false
name: taurochenodeoxycholate
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_fadef93c_6d81_4d2b_be47_ce5d4a4a95f5
is encoded by: hsa:48
initial amount: NaN
has only substance units: false
is: P21399
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ACO1

http://identifiers.org/biomodels.db/MODEL1310110037#_d7fea371_15fc_4293_a949_838761fb0110
type: Species
has only substance units: false
is: Q9H6Y6
is encoded by: hsa:4645
is: SBO:0000252
name: MYO5B
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaM ptrc e
initial concentration: 1.0
is: SBO:0000247
is: C00134
boundary condition: false
type: Species
has only substance units: false
is: HMDB01414
initial amount: NaN
constant: false
is: CHEBI:326268
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine

metaM atp e
type: Species
initial concentration: 1.0
has only substance units: false
is: C00002
initial amount: NaN
is: SBO:0000247
is: HMDB00538
is: CHEBI:57299
name: ATP(4-)
boundary condition: false
constant: false

metaM ppi x
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
is: C00013
initial amount: NaN
name: Diphosphate
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00250
is: CHEBI:33019

metaR r1301
reversible: false
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110037#
type: Reaction
name: Vesicular transport
reactant: MODEL1310110037#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_f6ca76d5_2832_4123_8f1c_b88f2b5b1303
is: P27707
initial concentration: NaN
name: DCK
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1633

http://identifiers.org/biomodels.db/MODEL1310110037#_000c839f_4667_4164_a5f8_aa5bb4e84652
has only substance units: false
is encoded by: hsa:3635
constant: false
is: SBO:0000252
boundary condition: true
is: Q92835
name: INPP5D
initial concentration: NaN
initial amount: NaN
type: Species

metaM CE2424 m
is: CHEBI:28387
is: HMDB11123
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_d51656c8_7684_4065_8a68_30cce0b9368e
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: B4DK61
boundary condition: true
is encoded by: hsa:51
initial concentration: NaN
name: ACOX1

metaR DNDPt9m
modifier: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
fast: false
reversible: false
reactant: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dTDP antiport

metaM pnto R e
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: HMDB00210
is: CHEBI:7916
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: (R)-Pantothenate

metaM HC01397 m
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:27402
name: (S)-3-Hydroxyhexadecanoyl-CoA
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
has only substance units: false
type: Species
boundary condition: false

metaR URAt
is: SBO:0000185
product: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000269
name: uracil transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
kinetic law: MODEL1310110037#
reversible: true

metaM ppcoa x
is: CHEBI:57392
constant: false
initial amount: NaN
is: SBO:0000247
name: Propanoyl-CoA
boundary condition: false
is: C00100
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
has only substance units: false
type: Species

metaR r0074
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
kinetic law: MODEL1310110037#

metaR r0641
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
reactant: MODEL1310110037#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4

metaM adrn e
is: SBO:0000247
is: CHEBI:53487
has only substance units: false
name: adrenic acid
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
type: Species
is: HMDB02226
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_940c2945_f23a_4fe4_bc07_298a0ea3d67d
is: SBO:0000252
is encoded by: hsa:125965
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: COX6B2
is: Q6YFQ2
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_8b436667_9ef5_400b_bf5b_147ba852927d
has only substance units: false
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: DPM2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8818

metaR r1302
name: Vesicular transport
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true

metaR ADSL1
name: adenylosuccinate lyase
kinetic law: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.3.2.2
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_39206c98_d653_44f7_9716_f6e2f20081c3
constant: false
has only substance units: false
type: Species
boundary condition: true
is: Q8TB61
name: SLC35B2
is encoded by: hsa:347734
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_e9158acb_5670_4400_8a23_1a837fa32cd3
constant: false
name: MDH2
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: P40926
is encoded by: hsa:4191
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_21ec2852_215b_45fe_b7db_806a9668f8fe
initial concentration: NaN
is: Q674R7
initial amount: NaN
name: ATG9B
constant: false
is encoded by: hsa:285973
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_738940ba_f23e_4686_9347_b9e2d39c6931
is: SBO:0000252
type: Species
boundary condition: true
name: IK
initial concentration: NaN
constant: false
has only substance units: false
is: Q13123
initial amount: NaN
is encoded by: hsa:3550

metaR 1PPDCRp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reversible: false
fast: false
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
is: SBO:0000176
name: delta1-piperideine-2-carboxylate reductase, perixosomal
reactant: MODEL1310110037#

metaR SPH1Pte
is: SBO:0000185
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: sph1p transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
type: Reaction

metaM nh4 e
initial amount: NaN
boundary condition: false
is: HMDB00051
initial concentration: 1.0
has only substance units: false
constant: false
name: ammonium
is: CHEBI:28938
is: SBO:0000247
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR RE3004M
name: RE3004
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_d91986b6_bfc2_4eba_bb6d_25f7722d9a60
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: PKM2
boundary condition: true
has only substance units: false
is encoded by: hsa:5315
is: P14618
initial concentration: NaN

metaM pi n
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:43474
initial concentration: 1.0
constant: false
name: hydrogenphosphate
boundary condition: false
is: HMDB00973

metaM tdchola e
initial amount: NaN
initial concentration: 1.0
name: taurochenodeoxycholate
is: SBO:0000247
is: HMDB00951
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
type: Species
has only substance units: false
is: CHEBI:9407

metaR RE1807C
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
name: RE1807
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_b9c54123_6df6_48c0_8585_02e4dbf1e901
initial concentration: NaN
is encoded by: hsa:1607
constant: false
is: SBO:0000252
boundary condition: true
name: DGKB
initial amount: NaN
has only substance units: false
type: Species

metaR RE0935E
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
is described by: ECO:0000000
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true

metaM galside hs c
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247

metaR ACt2m
name: acetate mitochondrial transport via proton symport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_01dbd48a_2868_4e7f_8779_a4768ad60909
name: EHHADH
is: Q9NY65
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:1962

metaM 56dura c
is: SBO:0000247
has only substance units: false
is: CHEBI:15901
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: HMDB00076
constant: false
name: 5,6-dihydrouracil
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR r0860
kinetic law: MODEL1310110037#
name: Utilized transport
is described by: ECO:0000000
product: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
fast: false
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction

metaM leuktrF4 e
is: CHEBI:27491
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
constant: false
name: leukotriene F4
is: HMDB06465
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_a212f16f_319c_461c_b92f_cd8aa3298ea0
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: BDH1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:622
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_bc7c79cf_e651_4838_b361_85a1d94eaf27
boundary condition: true
name: UCK2
initial amount: NaN
type: Species
is encoded by: hsa:7371
is: Q9BZX2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_90e5c314_c193_4b92_baef_bad030cb608b
name: AKR7A2
is: O43488
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8574
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM xylu D c
type: Species
is: CHEBI:17140
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
is: HMDB01644
boundary condition: false
name: D-xylulose
initial amount: NaN
is: SBO:0000247

metaR DSAT
name: dihydrosphingosine N-acyltransferase
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction

metaM pnto R c
is: SBO:0000247
is: HMDB00210
is: CHEBI:7916
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false
name: (R)-Pantothenate
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN

metaM pi m
constant: false
has only substance units: false
initial amount: NaN
name: hydrogenphosphate
boundary condition: false
is: C00009
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
initial concentration: 1.0
is: HMDB00973
is: CHEBI:43474

metaR PROt4 2 r
reactant: MODEL1310110037#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Proline transport (sodium symport) (2:1)
is described by: ECO:0000006
reversible: true
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM drib e
type: Species
is: HMDB03224
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
has only substance units: false
boundary condition: false
is: CHEBI:28816
name: 2-deoxy-D-ribose
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_281d58e9_6273_4593_947d_43e82300e554
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:56606
name: SLC2A9
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_b53d1231_6a0a_4b4f_b0b8_2a74ec5b60d2
type: Species
is: P33121
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ACSL1
constant: false
is encoded by: hsa:2180
initial concentration: NaN

metaR RETFAt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110037#
type: Reaction
reversible: false
kinetic law: MODEL1310110037#
name: fatty acid retinol efflux
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false

metaM pacald c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB06236
boundary condition: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: CHEBI:16424
constant: false
initial concentration: 1.0
type: Species
name: phenylacetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110037#_eae63e69_8f27_4fda_a4f4_5490a39c0027
is: P49753
is encoded by: hsa:10965
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ACOT2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_70b23693_cc61_4f66_b12f_91d84bf5505d
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q8IZV5
type: Species
has only substance units: false
is encoded by: hsa:157506
constant: false
name: RDH10

metaM hxan e
name: hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00157
is: CHEBI:17368
is: SBO:0000247
initial amount: NaN
type: Species

metaR EX gumtchol LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-taurocholic acid complex
type: Reaction

metaR AKR1D
kinetic law: MODEL1310110037#
reversible: false
product: MODEL1310110037#
is described by: ECO:0000269
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.1.3
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
modifier: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
type: Reaction
fast: false

metaM nh4 c
boundary condition: false
is: C01342
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
has only substance units: false
is: HMDB00051
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28938
constant: false
name: Ammonium
is: SBO:0000247
type: Species

metaM crn x
is: SBO:0000247
type: Species
name: L-Carnitine
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:16347
is: HMDB00062
constant: false
initial concentration: 1.0
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR ARGtm
product: MODEL1310110037#
name: arginine mitochondrial transport via ornithine carrier
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000185

metaM 34dhpha c
boundary condition: false
name: (3,4-dihydroxyphenyl)acetate
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB01336
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: CHEBI:17612

http://identifiers.org/biomodels.db/MODEL1310110037#_e6c9bfb1_a898_46ed_8b8b_f2599de22c5e
type: Species
is encoded by: hsa:5315
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PKM2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_63f8a1a7_2b3b_4adb_8b3d_81fb18461c41
constant: false
initial amount: NaN
name: PPA2
type: Species
has only substance units: false
is: F8WDN9
is: SBO:0000252
is encoded by: hsa:27068
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_acad1e35_2a6f_487c_aa49_f7c60ab7f802
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: COX7A2
type: Species
is encoded by: hsa:1347
initial concentration: NaN
constant: false
is: H0UI06

http://identifiers.org/biomodels.db/MODEL1310110037#_f1ea355d_1ad5_4381_8332_48355ea1f6fd
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:286297
is: SBO:0000252
boundary condition: true
name: _286297_1_c

metaR EBP1r
reversible: false
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.5
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110037#_1b5fef98_701f_4da5_be48_1202c19544da
has part: P15531
type: Species
name: NME1:NME2
initial concentration: NaN
constant: false
boundary condition: true
has part: P22392
has only substance units: false
initial amount: NaN
is encoded by: hsa:4831
is encoded by: hsa:4830
is: SBO:0000297

metaM atp r
constant: false
is: CHEBI:57299
name: ATP(4-)
type: Species
is: HMDB00538
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00002
initial concentration: 1.0
initial amount: NaN

metaM didp c
is: HMDB03536
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
name: dIDP
is: CHEBI:28823

http://identifiers.org/biomodels.db/MODEL1310110037#_647cf5e9_002c_4249_beab_d1e0fedda6e8
is: P00352
initial concentration: NaN
name: ALDH1A1
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:216
type: Species

metaR ALDD2y
reversible: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
type: Reaction
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is: SBO:0000176
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM glyb m
name: glycine betaine
constant: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00043
is: CHEBI:17750

metaM idp c
initial amount: NaN
is: HMDB03335
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
boundary condition: false
is: CHEBI:58280

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR DOLPMT4 Uer
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
fast: false
product: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110037#
reversible: false

metaM pi r
is: C00009
initial concentration: 1.0
type: Species
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
initial amount: NaN
constant: false
name: hydrogenphosphate
is: CHEBI:43474
is: HMDB00973
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_34e13132_d23c_48b8_a89a_da13b138b850
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PEMT
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:10400

metaR HISyLATtc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Histidine by y+LAT1 or y+LAT2 transporters in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_5bae23fe_11a5_430a_a5a5_5bceb73458d8
type: Species
name: DHCR24
boundary condition: true
initial amount: NaN
is encoded by: hsa:1718
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q15392

metaR ASNtm
type: Reaction
name: L-asparagine transport, mitochondrial
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reactant: MODEL1310110037#
reversible: false
product: MODEL1310110037#
is described by: ECO:0000000

metaM retinol cis 11 c
name: 11-cis-retinol
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16302
type: Species
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
boundary condition: false
is: HMDB06216

metaM ala L e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
name: L-alanine
is: CHEBI:16977
initial concentration: 1.0
initial amount: NaN
is: HMDB00161

metaR r1459
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110037#
name: Transport reaction
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185

metaR PItn
product: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: phosphate transport, nuclear
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
fast: false

metaR EX crmp hs LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ceramide 1-phosphate exchange
type: Reaction

metaM gpi hs r
is: CHEBI:16240
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB03125
initial amount: NaN
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
type: Species
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0

metaM hxan c
is: C00262
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
boundary condition: false
is: CHEBI:17368
initial amount: NaN
name: Hypoxanthine
type: Species
is: HMDB00157
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_221015b8_050c_45d9_922b_bb95d687fda8
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2821
name: GPI
is: P06744
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species

metaM em2emgacpail hs r
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:16240
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
is: HMDB03125

metaR RE1526M
is described by: ECO:0000000
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
kinetic law: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
fast: false
product: MODEL1310110037#
name: RE1526
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:

metaR r1681
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110037#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_68b58909_e88e_4a68_8f91_d2686f8d96fd
has only substance units: false
initial amount: NaN
name: LDHA
is: P00338
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:3939
constant: false

metaM retinol c
is: HMDB00305
has only substance units: false
name: retinol
boundary condition: false
is: CHEBI:50211
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3

http://identifiers.org/biomodels.db/MODEL1310110037#_c012b977_0914_40bd_9a5c_d2033204c78c
initial amount: NaN
is: G3V0F6
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: DGKZ
is encoded by: hsa:8525

metaM b2coa m
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57332
name: crotonoyl-CoA(4-)
constant: false
has only substance units: false
is: HMDB02009
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877

metaM leuktrE4 e
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
is: CHEBI:57462
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: leukotriene E4(1-)
constant: false
is: HMDB02200

metaM urate e
name: Urate
has only substance units: false
type: Species
is: C00366
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00289
initial amount: NaN
constant: false
is: CHEBI:17775
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366

metaR ASCBt4
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
name: L-ascorbate transport via proton symport
kinetic law: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_8ce889ee_35ab_4368_87f2_0b364fd3d6a5
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:26
is: P19801
boundary condition: true
initial concentration: NaN
name: ABP1

metaR CYTK2n
fast: false
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110037#
reversible: true
product: MODEL1310110037#
is: SBO:0000176
name: cytidylate kinase (dCMP),nuclear

metaM xolest2 hs e
name: cholesterol ester
boundary condition: false
is: CHEBI:17002
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR DADNt4
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
name: deoxyadenosine transport via diffusion

metaM cholp c
initial concentration: 1.0
constant: false
name: choline phosphate(1-)
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: CHEBI:295975
initial amount: NaN

metaR r0354
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
reactant: MODEL1310110037#
fast: false
product: MODEL1310110037#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
type: Reaction

metaM idp e
is: HMDB03335
constant: false
has only substance units: false
is: CHEBI:58280
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR PIPLCn
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
modifier: MODEL1310110037#
fast: false
name: phosphatidylinositol phospholipase C, nucleus
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction

metaR UMPKn
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
kinetic law: MODEL1310110037#
name: UMP kinase, nuclear

metaM ala L c
is: HMDB00161
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
constant: false
is: SBO:0000247
name: L-alanine
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:16977

metaM HC01162 c
initial concentration: 1.0
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: CHEBI:58376
type: Species

metaR DAGKn hs
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.107
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
name: Diacylglycerol phosphate kinase (homo sapiens)
fast: false
is: SBO:0000176

metaR ALDD2x
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
name: aldehyde dehydrogenase (acetaldehyde, NAD)
type: Reaction
reversible: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_28cd11e3_f79c_4b26_9309_ec1aca1cc780
is encoded by: hsa:AI191472
type: Species
initial amount: NaN
constant: false
name: _AI191472_1_c
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM nadph r
initial amount: NaN
is: CHEBI:57783
is: SBO:0000247
constant: false
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
has only substance units: false
is: HMDB00221
boundary condition: false
type: Species

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaM lnlccrn m
type: Species
has only substance units: false
name: Linoleyl carnitine
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
is: SBO:0000247
is: HMDB06469
boundary condition: false

metaR MCLACCYSR
product: MODEL1310110037#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
name: 3-mercaptolactate:cysteine reductase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_4e3a8757_71a7_48cf_afcd_f079d10afdf6
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI620219
constant: false
initial concentration: NaN
initial amount: NaN
name: _AI620219_1_m
boundary condition: true

metaM gthox m
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB03337
is: CHEBI:58297
has only substance units: false

metaM 5adtststerone c
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
has only substance units: false
is: HMDB02961

http://identifiers.org/biomodels.db/MODEL1310110037#_f867d2fc_2151_4b1d_9ffc_feee1fbb03a6
is encoded by: hsa:8818
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:5277
initial amount: NaN
has part: P37287
boundary condition: true
type: Species
is: SBO:0000297

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaM leuktrE4 c
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57462
has only substance units: false
name: leukotriene E4(1-)
is: SBO:0000247
initial amount: NaN
is: HMDB02200
type: Species

metaM urate c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: HMDB00289
is: CHEBI:17775
constant: false
boundary condition: false
name: Urate
initial amount: NaN
is: SBO:0000247
is: C00366
type: Species

metaM dcsptn1coa x
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB06513
has only substance units: false
is: C16173
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_9bcc480c_c608_46fe_91da_dbc34d361e23
is encoded by: hsa:HG2846-HT2983
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _HG2846_HT2983_1_c
constant: false
has only substance units: false

metaR PNTK
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: pantothenate kinase
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false
reversible: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

MODEL1310110037
species: metaM 3oddcoa m
species: metaM cmp n
species: metaM arg L e
species: metaM 4ppcys c
reaction: metaR 5MTHFt
reaction: metaR r2131
species: metaM 1pipdn2c x
reaction: metaR EX pnto R LPAREN e RPAREN
reaction: metaR EX ctp LPAREN e RPAREN
reaction: metaR r0812
reaction: metaR r0963
reaction: metaR GLYBt4 2 r
species: metaM dcacoa m
reaction: metaR EX leu L LPAREN e RPAREN
reaction: metaR EX csn LPAREN e RPAREN
reaction: metaR r2308
reaction: metaR RE1898C
reaction: metaR PNTOte
species: metaM aps c
species: metaM pail hs n
reaction: metaR SGPL12r
species: metaM mercplac c
reaction: metaR EX CE1926 LPAREN e RPAREN
species: metaM lnlnca l
reaction: metaR PAPtg
reaction: metaR PROSTGF2t
species: metaM oaa m
species: metaM fadh2 m
reaction: metaR EX malthp LPAREN e RPAREN
reaction: metaR r1914
reaction: metaR RETH
reaction: metaR DUDPtn
reaction: metaR HISSNAT5tc
reaction: metaR CYTK12n
species: metaM ca2 e
reaction: metaR r0559
reaction: metaR DUMPtn
reaction: metaR CMPSASn
species: metaM pail4p hs n
species: metaM 12ppd S c
species: metaM dgdp m
species: metaM CE5160 r
reaction: metaR EX pe hs LPAREN e RPAREN
species: metaM thr L e
reaction: metaR r0497
reaction: metaR PGS
species: metaM HC00718 c
reaction: metaR r1570
species: metaM ump r
species: metaM pro D c
reaction: metaR EX ascb L LPAREN e RPAREN
reaction: metaR INSTt2r
reaction: metaR EX HC01609 LPAREN e RPAREN
reaction: metaR NH4tn
species: metaM thp2c c
reaction: metaR r2388
species: metaM dcdp m
reaction: metaR ORNt4m
species: metaM pap c
reaction: metaR r1384
reaction: metaR VALTA
reaction: metaR KHK
species: metaM ser D e
species: metaM dgtp c
species: metaM dolp U c
reaction: metaR SPHS1Pte
reaction: metaR CYTK4
species: metaM idp n
species: metaM nadph r
species: metaM atp r
reaction: metaR GCC2cm
species: metaM hpyr c
reaction: metaR VALt5m
reaction: metaR PHCDm
reaction: metaR THBPT4ACAMDASE
species: metaM gdp c
reaction: metaR r1301
reaction: metaR r0408
reaction: metaR FRUt4
reaction: metaR r0973

metaM retinol e
initial concentration: 1.0
is: HMDB00305
is: CHEBI:50211
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
has only substance units: false
name: retinol
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaR ORNt4m
modifier: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reversible: true
name: ornithine mitochondrial transport exchange with citruline
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_73e71c8e_1a95_4f4f_96a9_65ddc0790e64
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _H77542_1_r
initial concentration: NaN
type: Species
is encoded by: hsa:H77542
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_9511c4ef_9cfd_4cf8_bfbe_07c972f9e930
initial amount: NaN
type: Species
name: GGT3P
has only substance units: false
boundary condition: true
is encoded by: hsa:2679
constant: false
is: SBO:0000252
initial concentration: NaN

metaM inost e
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
initial amount: NaN
boundary condition: false
is: HMDB00211
is: SBO:0000247
name: myo-inositol
has only substance units: false

metaR FUMTSULtm
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: Fumarate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110037#

metaM atp m
initial amount: NaN
boundary condition: false
is: CHEBI:57299
name: ATP(4-)
is: C00002
constant: false
is: SBO:0000247
is: HMDB00538
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_c6782180_e61f_4143_a996_969ce57abd20
boundary condition: true
is encoded by: hsa:6561
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: Q9BZW2
name: SLC13A1

metaR r1454
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reversible: false

metaR RE0830N
reversible: true
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000176
name: RE0830

http://identifiers.org/biomodels.db/MODEL1310110037#_dce090c1_689a_4d0a_9de0_898f7fbc11ed
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is: P35219
initial amount: NaN
name: CA8
is encoded by: hsa:767
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_e549e312_a7b0_4a26_8bb2_a0718444ce4a
initial concentration: NaN
is encoded by: hsa:AA526438
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: _AA526438_1_c
boundary condition: true

metaM glyald m
initial amount: NaN
is: CHEBI:17378
is: SBO:0000247
is: HMDB01051
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
boundary condition: false
constant: false
name: D-glyceraldehyde

http://identifiers.org/biomodels.db/MODEL1310110037#_c66ca984_dab0_426f_8b26_7664c1e1daa3
type: Species
is: Q16836
is: SBO:0000252
boundary condition: true
constant: false
name: HADH
initial concentration: NaN
is encoded by: hsa:3033
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_0d6c364d_8e26_4051_9f93_4e8ccd299366
is encoded by: hsa:51
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACOX1
has only substance units: false
is: B4DK61
initial amount: NaN
boundary condition: true

metaM succ m
is: CHEBI:30031
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
name: Succinate
initial amount: NaN
is: C00042
has only substance units: false
is: SBO:0000247
is: HMDB00254

metaR PIter
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
name: phosphate transport, endoplasmic reticulum
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
fast: false
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_795e9902_729d_4175_8851_3f26cd91dde2
initial concentration: NaN
type: Species
initial amount: NaN
is: Q5JRA6
is encoded by: hsa:375056
has only substance units: false
name: MIA3
is: SBO:0000252
constant: false
boundary condition: true

metaM fmn c
boundary condition: false
is: HMDB01520
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:58210
has only substance units: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: C00061
constant: false
name: FMN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_1ef8b615_60c6_47a4_a4e6_1285a4933dd7
name: UEVLD
boundary condition: true
is encoded by: hsa:55293
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: Q8IX04
initial concentration: NaN
is: SBO:0000252

metaR FAOXC2051843m
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
name: Beta oxidation of fatty acid
type: Reaction
modifier: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110037#_c08504b7_3ad6_4857_b75a_542d3e857b6c
is: SBO:0000252
name: FOLR1
is encoded by: hsa:2348
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: P15328
has only substance units: false

metaR LCADi D
is described by: ECO:0000304
product: MODEL1310110037#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
name: lactaldehyde dehydrogenase
is: SBO:0000176
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

metaR CSND
product: MODEL1310110037#
is: SBO:0000176
name: Cytosine deaminase
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_a0a91d74_5f35_4b7e_b69f_2c18a27a8eae
has only substance units: false
initial amount: NaN
name: ALDH3B2
is: P48448
constant: false
type: Species
is encoded by: hsa:222
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r0355
kinetic law: MODEL1310110037#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
product: MODEL1310110037#

metaM uacgam r
is: CHEBI:57705
constant: false
is: HMDB00290
initial concentration: 1.0
type: Species
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
initial amount: NaN
has only substance units: false

metaM atp n
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
name: ATP(3-)
constant: false
is: SBO:0000247
is: HMDB00538
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57299

http://identifiers.org/biomodels.db/MODEL1310110037#_7ec48122_17a2_447c_a5ad_d6cb0db66c93
is: SBO:0000252
constant: false
boundary condition: true
is: O43868
initial amount: NaN
initial concentration: NaN
name: SLC28A2
type: Species
is encoded by: hsa:9153
has only substance units: false

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM crn m
boundary condition: false
constant: false
is: C00318
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: SBO:0000247
name: L-Carnitine
is: CHEBI:16347

metaR AMETtd
kinetic law: MODEL1310110037#
reversible: true
type: Reaction
product: MODEL1310110037#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: diffusion of S-Adenosyl-L-methionine
is described by: ECO:0000134
reactant: MODEL1310110037#

metaR r1599
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR NDPK6m
is described by: ECO:0000254
reversible: true
type: Reaction
product: MODEL1310110037#
modifier: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reactant: MODEL1310110037#

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM sphings c
name: sphingosine(1+)
boundary condition: false
is: SBO:0000247
is: CHEBI:57756
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
has only substance units: false
is: HMDB00252
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false

metaM Lcystin c
boundary condition: false
constant: false
type: Species
has only substance units: false
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
name: L-cystine
initial concentration: 1.0
is: HMDB00192
is: SBO:0000247

metaM 3mop m
is: CHEBI:28654
initial amount: NaN
is: HMDB00491
name: 3-methyl-2-oxopentanoate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
constant: false
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_d558471b_0b80_471d_9e59_1f500e6e7d29
is encoded by: hsa:1807
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: DPYS
is: Q14117
is: SBO:0000252

metaM ppi r
is: C00013
initial amount: NaN
is: HMDB00250
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: Diphosphate
has only substance units: false
is: CHEBI:33019

metaM inost c
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
boundary condition: false
has only substance units: false
initial amount: NaN
name: myo-inositol
is: HMDB00211
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_e59787c1_d5b7_40a3_b45b_4285b8f1043c
boundary condition: true
is encoded by: hsa:4831
type: Species
is: SBO:0000252
name: NME2
has only substance units: false
is: P22392
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_89f30f9c_e851_4169_a2f5_8599dc04760e
boundary condition: true
name: NMNAT3
has only substance units: false
type: Species
is: SBO:0000252
is: Q96T66
constant: false
initial concentration: NaN
is encoded by: hsa:349565
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_8a41eb29_74fd_4079_9b5c_17568b486e04
is encoded by: hsa:7296
type: Species
has only substance units: false
name: TXNRD1
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR GLUTCOADHm
fast: false
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
reactant: MODEL1310110037#
name: glutaryl-CoA dehydrogenase (mitochondria)
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.7
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110037#

metaR r1384
product: MODEL1310110037#
type: Reaction
name: Guanosine aminohydrolase EC:3.5.4.15
is: SBO:0000176
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:

metaM xol7ah2 c
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
is: CHEBI:28047
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452

metaR UMPK4n
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (GTP),nuclear
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
reversible: true
modifier: MODEL1310110037#

metaR r1598
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM so3 m
constant: false
is: CHEBI:17137
has only substance units: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
name: hydrogensulfite
boundary condition: false
is: HMDB00240
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM nadph m
constant: false
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57783
is: C00005
type: Species
is: SBO:0000247
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaR r0580
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.7
modifier: MODEL1310110037#
fast: false
reversible: true
is: SBO:0000176
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM 3m4hpga c
type: Species
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
is: http://identifiers.org/pubchem.compound/7909
initial amount: NaN
boundary condition: false
is: HMDB04061
is: C05583
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
has only substance units: false

metaM adrncoa x
is: C16170
name: adrenyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205480
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110037#_b52e3e2d_e1de_4f58_8b75_a8a723faf440
is: O43426
name: SYNJ1
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:8867
initial amount: NaN
type: Species
has only substance units: false

metaM fmn e
is: HMDB01520
boundary condition: false
notes: FORMULA: C17H19N4O9P CHARGE: -2
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:58210
is: C00061
type: Species
has only substance units: false
name: FMN

metaM acac m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: acetoacetate
type: Species
is: HMDB00060
has only substance units: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
constant: false

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_44364b86_6d82_4145_b7e4_8d95ca8fa5aa
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:5160
type: Species
is: SBO:0000297
name: DLAT:DLD:PDHA1:PDHB:PDHX
has only substance units: false
has part: P08559

metaR ADK3m
name: adentylate kinase (GTP)
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.10
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
reversible: true

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM Rtotal2 e
initial concentration: 1.0
is: HMDB00244
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
boundary condition: false
name: R total 2 position
is: C00255
constant: false
is: CHEBI:3554

metaR r1453
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110037#
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
type: Reaction
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_693b6672_f3ee_4969_b54d_1ed38dc8fd16
has only substance units: false
type: Species
boundary condition: true
is: O76062
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7108
initial amount: NaN
constant: false
name: TM7SF2

metaR NDPK6n
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000176
product: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110037#
fast: false

metaR RE3244R
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
name: RE3244
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110037#
type: Reaction
reversible: true

metaR r1597
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM crn c
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
initial amount: NaN
type: Species
is: C00318
boundary condition: false
name: L-Carnitine
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR GLCt1r
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
name: glucose transport (uniport)

metaM glysar c
type: Species
name: Glycylsarcosine
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/93131
initial concentration: 1.0
is: SBO:0000247

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR SARDHm
fast: false
modifier: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.99.1
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000269
reversible: false
name: Sarcosine dehydrogenase (m)
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable

http://identifiers.org/biomodels.db/MODEL1310110037#_3667be9f_8e64_4ccb_a9b5_c5585a656d48
is: P18405
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6715
name: SRD5A1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_18e79492_08fa_4aaa_b66c_a10c46a10a74
boundary condition: true
type: Species
name: GLRX2
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51022
is: Q9NS18
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_821776ec_78c4_4fc9_8438_95e8cd0716e9
constant: false
boundary condition: true
has only substance units: false
is: E7EUT4
is encoded by: hsa:2597
type: Species
initial concentration: NaN
is: SBO:0000252
name: GAPDH
initial amount: NaN

metaM glu L l
name: L-glutamate(1-)
constant: false
type: Species
initial amount: NaN
is: CHEBI:29985
is: HMDB00148
initial concentration: 1.0
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR DRPA
is described by: ECO:0000000
type: Reaction
reversible: false
name: deoxyribose-phosphate aldolase
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110037#

metaR r0502
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.1.113
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
fast: false
modifier: MODEL1310110037#

metaM pect e
is: HMDB03402
name: pectins
notes: FORMULA: C2535H3509O2535 CHARGE: -1
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaM HC01408 m
constant: false
is: CHEBI:27648
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
name: 3-Oxohexanoyl-CoA
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_503c289a_e24c_4fee_b519_21256ecf0b7c
constant: false
is: P09543
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:1267
boundary condition: true
is: SBO:0000252
name: CNP

metaR r0584
reversible: true
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM ppcoa m
constant: false
type: Species
name: Propanoyl-CoA
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01275
is: SBO:0000247
is: C00100
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaR r1662
reactant: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
reversible: true

metaR BAAT1x
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110037#
is described by: ECO:0000269
is: SBO:0000176
fast: false
kinetic law: MODEL1310110037#
name: bile acid Coenzyme A: amino acid N-acyltransferase
reversible: false
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_814ce1c2_bccd_49bb_9514_a0ac5e989924
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: NDUFA1
is encoded by: hsa:4694
is: Q6IBB5
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_121d30b3_95a2_491f_9520_097893a5bcc8
type: Species
name: PCBD1
has only substance units: false
is encoded by: hsa:5092
is: P61457
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM glu L m
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
name: L-glutamate(1-)
is: CHEBI:29985
is: HMDB00148
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_36de57db_8d84_452d_aeed_1b412b21cc4f
boundary condition: true
is: P00374
initial amount: NaN
name: DHFR
is encoded by: hsa:1719
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM xol7a r
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:1296
boundary condition: false
is: HMDB01496
name: 20-hydroxycholesterol
constant: false
has only substance units: false
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594

metaM dhdascb e
is: CHEBI:58070
name: dehydroascorbide(1-)
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB01264
initial concentration: 1.0
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425

metaM 2dr5p c
name: 2-deoxy-D-ribose 5-phosphate(2-)
initial amount: NaN
boundary condition: false
is: HMDB01031
constant: false
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57651
has only substance units: false

metaM strch2 e
initial concentration: 1.0
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0
is: HMDB00122
is: CHEBI:4167
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_d37f233a_f3a9_43dd_8d39_29381c788f0a
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:158
name: ADSL
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_1b1ec6a6_b427_468f_9b10_6c2c6bdcb757
type: Species
has only substance units: false
is: Q05C14
name: FOLR3
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2352

metaR r1512
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
name: Utilized transport
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110037#

metaR r1665
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110037#
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r2520
reactant: MODEL1310110037#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
product: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
is: SBO:0000185
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_ba4262b8_57e2_4db5_aa53_1b0fa5271fea
constant: false
is: O75452
has only substance units: false
initial concentration: NaN
name: RDH16
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8608
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_1afb854e_a051_4001_8f82_671ac2035046
is encoded by: hsa:8875
constant: false
has only substance units: false
is: O95498
initial amount: NaN
name: VNN2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaR r1147
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
product: MODEL1310110037#
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
type: Reaction

metaM acgam r
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
type: Species
constant: false
initial concentration: 1.0
is: HMDB00215
is: CHEBI:17411
is: SBO:0000247
has only substance units: false
name: N-acetyl-D-glucosamine
boundary condition: false

metaM glutcoa m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
name: glutaryl-CoA(5-)
is: CHEBI:57378
is: HMDB01339
type: Species
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_64437a31_a9bd_49c0_bb35_9e56cda60219
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7167
constant: false
type: Species
boundary condition: true
name: TPI1
initial amount: NaN
is: SBO:0000252
is: Q53HE2

http://identifiers.org/biomodels.db/MODEL1310110037#_7bc5e381_27ff_45e4_acc4_cd79e8c09bd3
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:1593
initial concentration: NaN
has only substance units: false
name: CYP27A1
is: Q02318
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_036e09a8_5416_477f_b16e_13804bd4d22f
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC1A6
is: P48664
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:6511
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_83ae281e_faf6_4645_9542_19f14448c96d
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q96P26
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:93034
initial amount: NaN
name: NT5C1B

http://identifiers.org/biomodels.db/MODEL1310110037#_d5ea6e6d_5162_4a4a_8e9c_f9505eefada4
initial concentration: NaN
boundary condition: true
has part: Q8NCI4
is: SBO:0000297
constant: false
is encoded by: hsa:54872
initial amount: NaN
type: Species
has only substance units: false
name: PIGF:PIGG

metaR r0504
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
modifier: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_9f2e336a_8893_4b98_8678_88b302b46837
initial concentration: NaN
name: SLC5A12
boundary condition: true
is encoded by: hsa:159963
constant: false
is: SBO:0000252
is: Q1EHB4
has only substance units: false
type: Species
initial amount: NaN

metaM pmtcoa r
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: CHEBI:3454
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
boundary condition: false
is: C00154

metaR CYTDtm
reversible: true
is described by: ECO:0000269
fast: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000185
name: cytidine facilated transport in mitochondria

metaM xu1p D c
initial concentration: 1.0
boundary condition: false
is: HMDB06534
type: Species
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
is: SBO:0000247
constant: false
name: D-Xylulose 1-phosphate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_36ab1451_31f0_4b68_aa4d_e2395dc1ffe7
initial amount: NaN
is encoded by: hsa:5277
is encoded by: hsa:8818
has only substance units: false
is encoded by: hsa:51227
has part: B3KUV7
has part: Q9BRB3
is encoded by: hsa:5279
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: O94777
is encoded by: hsa:5283
type: Species
is encoded by: hsa:9091
has part: Q92535
initial concentration: NaN
is: SBO:0000297
has part: Q14442
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_76f50d3f_6ea4_48db_a631_ea5298341042
has only substance units: false
name: _R39999_1_c
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:R39999
initial amount: NaN
constant: false
is: SBO:0000252

metaM lnlc r
name: linoleate
is: CHEBI:30245
is: SBO:0000247
is: HMDB00673
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_531ee60a_df94_4283_85b6_9d97d2788e7e
initial amount: NaN
is: SBO:0000252
name: SLC17A3
is encoded by: hsa:10786
type: Species
is: O00476
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaR LYStm
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
name: Lysine mitochondrial transport via ornithine carrier
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR r1664
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_d8ce8ff6_2214_4f57_9c04_bcd08ea8ab88
has only substance units: false
is encoded by: hsa:AL050025
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: _AL050025_1_c

http://identifiers.org/biomodels.db/MODEL1310110037#_c309b07c_5d5e_4133_83b7_c4b13dcc677c
is: SBO:0000252
initial concentration: NaN
is: P14060
type: Species
name: HSD3B1
initial amount: NaN
boundary condition: true
is encoded by: hsa:3283
constant: false
has only substance units: false

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM oaa c
boundary condition: false
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2
name: Oxaloacetate
is: C00036
initial concentration: 1.0
is: HMDB00223
is: CHEBI:3338
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaR RE1525M
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1525
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reversible: true
type: Reaction
modifier: MODEL1310110037#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_89da7d80_d4ff_470c_b1cc_9c5de63566ca
name: SLC16A1
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6566
has only substance units: false
is: B4DKS0
initial concentration: NaN

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR r0587
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
type: Reaction
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR r2201
reactant: MODEL1310110037#
reversible: true
type: Reaction
modifier: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
is: SBO:0000185
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110037#

metaM 10fthf6glu e
name: 10-formyltetrahydrofolate-[Glu](6)
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00108
has only substance units: false
initial amount: NaN
is: CHEBI:16236
boundary condition: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1

metaR 5MTHFt2le
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: 5-methyltetrahydrofolate transport via anion exchange
product: MODEL1310110037#
is: SBO:0000185
type: Reaction
fast: false

metaM hdca l
has only substance units: false
name: palmitate
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
type: Species
is: HMDB00220
is: SBO:0000247
constant: false
is: CHEBI:7896
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_f167a8d8_c842_4787_9ff3_ad42acd54799
is encoded by: hsa:AA081045
is: SBO:0000252
name: _AA081045_1_c
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_1c463008_b6d5_402e_8911_7f0cacc74285
is: P32019
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: INPP5B
constant: false
is encoded by: hsa:3633

metaM xol7ah2 m
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:28047
is: HMDB06893
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha-diol
has only substance units: false
is: SBO:0000247
type: Species

metaM s7p c
is: CHEBI:57483
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: C05382
is: HMDB01068
name: Sedoheptulose 7-phosphate
constant: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_59029cca_1881_4d88_b517_edb521a2a52f
is: Q07326
initial concentration: NaN
name: PIGF
constant: false
is: SBO:0000252
is encoded by: hsa:5281
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_b36a9885_9190_4763_8bec_0d48ee746d16
is encoded by: hsa:8818
constant: false
has only substance units: false
is: SBO:0000252
name: DPM2
is: O94777
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_0bf6431c_275d_4c0c_9d28_115eb122d7fc
is encoded by: hsa:BC005314
type: Species
name: _BC005314_1_x
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3083f74a_bcd7_4643_8015_3015dbfa1a6c
is: P31350
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: RRM2
type: Species
boundary condition: true
is encoded by: hsa:6241
initial amount: NaN

metaR It
is described by: ECO:0000269
product: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
modifier: MODEL1310110037#
reversible: true
name: Iodide uniport
fast: false

metaM HC00250 c
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
boundary condition: false
name: hydrosulfide
is: CHEBI:29919
initial amount: NaN
has only substance units: false

metaM acac e
type: Species
is: SBO:0000247
constant: false
is: HMDB00060
is: CHEBI:13705
name: acetoacetate
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
has only substance units: false

metaR r2389
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
modifier: MODEL1310110037#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_772fc5e2_6d45_4f39_8bf4_7438ddfdcbc8
initial amount: NaN
is: Q86SK9
boundary condition: true
constant: false
name: SCD5
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:79966

metaR PROSTGH2t
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin H2 transport
fast: false
type: Reaction
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_9fff2fef_e78a_4f4f_8107_6852d73cd6b8
is: Q96KJ9
constant: false
initial concentration: NaN
name: COX4I2
is encoded by: hsa:84701
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_845a9844_775c_42c8_9cae_f43b0d92f874
is: SBO:0000252
has only substance units: false
name: _AI620219_1_e
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI620219
initial amount: NaN
constant: false

metaR r2401
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110037#

metaR r0202
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110037#
reversible: true
type: Reaction
fast: false
product: MODEL1310110037#

metaR r2521
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
fast: false
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Utilized transport
kinetic law: MODEL1310110037#
reversible: true

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_8b4d2c9b_30b8_42b3_9d69_d48ecf5a8fc6
name: ENTPD3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:956
has only substance units: false
is: SBO:0000252
type: Species
is: O75355
constant: false
boundary condition: true

metaR GUMTCHOLe
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR r2200
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_42873ea1_2ed2_4815_a722_2eee680095b2
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC24A4
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:123041
has only substance units: false

metaM dhap c
has only substance units: false
boundary condition: false
is: CHEBI:57642
is: http://identifiers.org/pubchem.compound/3411
constant: false
is: SBO:0000247
is: HMDB01473
name: Dihydroxyacetone phosphate
is: C00111
initial amount: NaN
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_f62a7fba_fa9c_4856_8d26_e41fb05c59b1
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: GUSB
has only substance units: false
boundary condition: true
is: P08236
is encoded by: hsa:2990

metaM cmp e
constant: false
is: HMDB00095
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
type: Species
is: CHEBI:60377

metaM co2 e
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16526
is: C00011
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
name: CO2
is: HMDB01967

metaM atp x
has only substance units: false
initial concentration: 1.0
is: CHEBI:57299
constant: false
is: C00002
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00538
initial amount: NaN
name: ATP(4-)

metaM tststerone c
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
constant: false
name: testosterone
is: HMDB00234
is: SBO:0000247
is: CHEBI:17347
type: Species

metaM dump n
initial amount: NaN
type: Species
has only substance units: false
name: dUMP(2-)
is: HMDB01409
boundary condition: false
constant: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
is: CHEBI:246422
is: SBO:0000247

metaM tchola x
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
is: HMDB00036
boundary condition: false
is: CHEBI:36257
name: taurocholate
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_32bf16a4_e769_4819_90cf_b042c82aae79
type: Species
is encoded by: hsa:80055
name: PGAP1
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: Q75T13
has only substance units: false
initial concentration: NaN

metaM gthox c
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
is: SBO:0000247
is: C00127
name: Oxidized glutathione
boundary condition: false
initial amount: NaN
is: CHEBI:58297
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

metaR ACGAMK
is: SBO:0000176
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
reversible: false
fast: false
name: N-acetylglucosamine kinase
modifier: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.59

metaR r1661
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000185
modifier: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_abc5283f_4a6b_4815_bbed_d31afca9362c
initial amount: NaN
is: P04745
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: AMY1C
type: Species
is encoded by: hsa:278

metaR r2388
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is: SBO:0000185

metaM glysar e
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/93131
notes: FORMULA: C5H10N2O3 CHARGE: 0
constant: false
has only substance units: false
name: Glycylsarcosine
boundary condition: false
initial concentration: 1.0
type: Species

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM HC00250 e
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
type: Species
boundary condition: false
name: hydrosulfide
is: CHEBI:29919
initial amount: NaN

metaM acac c
type: Species
is: SBO:0000247
constant: false
name: acetoacetate
is: HMDB00060
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3eb9c63a_522c_48b1_8d9a_0b2a1396e0bb
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:AI378339
name: _AI378339_1_m
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_da02a541_c502_476f_8e67_a9a3ecf37bed
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:28976
name: ACAD9
is: SBO:0000252
has only substance units: false
is: Q9H845
boundary condition: true
constant: false

metaR ITPtn
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: ITP nuclear transport
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_de899aae_4f78_4dd0_af41_56c3ad437e56
boundary condition: true
name: NMNAT2
is encoded by: hsa:23057
is: Q9BZQ4
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR r1660
modifier: MODEL1310110037#
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true

metaR r2387
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110037#
modifier: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR FBA
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13
name: fructose-bisphosphate aldolase
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is described by: ECO:0000134
reversible: true
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
fast: false

metaR SARCStm
name: Sarcosine transport (mitochondrial)
reversible: false
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM dhap e
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
type: Species
is: CHEBI:57642
initial amount: NaN
name: glycerone phosphate(2-)
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB01473
boundary condition: false
initial concentration: 1.0

metaM pmtcoa m
is: SBO:0000247
is: C00154
constant: false
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: CHEBI:57379
is: HMDB01338

metaM C05279 m
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: trans,cis-Lauro-2,6-dienoyl-CoA
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247
initial amount: NaN
is: HMDB11123
constant: false
type: Species
is: CHEBI:28387

metaM cmp c
is: C00055
is: HMDB00095
has only substance units: false
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
name: CMP
is: CHEBI:60377

metaM co2 c
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:3313
initial amount: NaN
is: C00011
name: CO2
is: SBO:0000247
type: Species

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_df221995_81fd_460c_9735_6987389f2469
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: BCAT2
type: Species
is: O15382
is: SBO:0000252
is encoded by: hsa:587

http://identifiers.org/biomodels.db/MODEL1310110037#_3f065b2b_953c_474f_a3e1_2677ba181245
constant: false
is: SBO:0000297
has only substance units: false
initial concentration: NaN
name: NME1:NME2
is encoded by: hsa:4830
boundary condition: true
type: Species
initial amount: NaN

metaR SQLSr
is: SBO:0000176
name: Squalene synthase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
reversible: false
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.21
modifier: MODEL1310110037#

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_548fd60e_7d9b_4520_a496_460007d5d0ef
type: Species
name: ATP2B4
constant: false
is: SBO:0000252
is: P23634
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:493
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_a8957c66_4605_435a_abfa_80bead672fbf
type: Species
has only substance units: false
constant: false
name: SLC25A4
is: P12235
boundary condition: true
is encoded by: hsa:291
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_0c37a962_1e0e_41ea_bfe6_a9623773cc87
initial concentration: NaN
is: P48735
name: IDH2
type: Species
constant: false
is encoded by: hsa:3418
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaM acgam l
initial amount: NaN
is: HMDB00215
boundary condition: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: N-acetyl-D-glucosamine
is: SBO:0000247

metaM dcsptn1coa m
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: SBO:0000247
is: C16173
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_8115e369_6c3c_4e98_9fab_62c773dabe21
is: SBO:0000252
name: ACSL6
initial amount: NaN
is encoded by: hsa:23305
has only substance units: false
initial concentration: NaN
is: B2RB13
constant: false
type: Species
boundary condition: true

metaR HIStiDF
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
modifier: MODEL1310110037#
reversible: false
product: MODEL1310110037#
name: L-histidine transport via diffusion (extracellular to cytosol)

metaR r2526
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110037#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR r0437
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is version of: http://identifiers.org/ec-code/4.1.2.13
type: Reaction
is: SBO:0000176
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reversible: true

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_94531db1_ddec_4256_9f51_a2fa4e51e9db
initial amount: NaN
constant: false
name: ALDH1A2
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:8854
is: B4DZR2
boundary condition: true
initial concentration: NaN

metaR r0153
type: Reaction
kinetic law: MODEL1310110037#
reversible: false
product: MODEL1310110037#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is: SBO:0000176
modifier: MODEL1310110037#
reactant: MODEL1310110037#
name: CTP:pyruvate O2-phosphotransferase EC:2.7.1.40

metaR r2386
modifier: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_9c76c384_617b_4751_90cb_22fce5eff2c6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1892
type: Species
name: ECHS1
constant: false
has only substance units: false
is: P30084
boundary condition: true
initial concentration: NaN

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaR r2404
reversible: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110037#
fast: false

metaR NAIt
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000269
reactant: MODEL1310110037#
modifier: MODEL1310110037#
name: Na+ / iodide cotransport
reversible: true
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
type: Reaction
product: MODEL1310110037#

metaM g3p c
constant: false
has only substance units: false
is: SBO:0000247
is: C00661
name: Glyceraldehyde 3-phosphate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58027
boundary condition: false
is: HMDB01112
type: Species
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: http://identifiers.org/pubchem.compound/3930

http://identifiers.org/biomodels.db/MODEL1310110037#_cd23d588_1398_470d_8770_94e84ea9bad7
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O00219
is encoded by: hsa:3038
constant: false
type: Species
has only substance units: false
name: HAS3

http://identifiers.org/biomodels.db/MODEL1310110037#_a293bf3e_33b8_4561_8c29_3a0c372384c1
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: P05091
name: ALDH2
is encoded by: hsa:217
constant: false

metaM fol c
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00121
boundary condition: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
has only substance units: false
name: Folate

metaR PRPNCOAHYDm
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
name: Propenoyl-CoA hydrolase (m)
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is described by: ECO:0000134
modifier: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r0509
reversible: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000176
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1

metaR RTOTALt
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true
name: RTOTAL transport
fast: false

metaM thyox L e
boundary condition: false
initial amount: NaN
is: HMDB00248
initial concentration: 1.0
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false
name: L-thyroxine
is: CHEBI:18332
is: SBO:0000247
type: Species

metaR r1930
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
modifier: MODEL1310110037#
reversible: false
type: Reaction
is described by: ECO:0000000

metaR r2385
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
fast: false
reversible: false
modifier: MODEL1310110037#
product: MODEL1310110037#

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

http://identifiers.org/biomodels.db/MODEL1310110037#_0ef1fad0_a17b_4e64_9fc4_69b169b8b126
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ACADS
initial amount: NaN
is encoded by: hsa:35
constant: false
is: P16219
boundary condition: true

metaR FAOXC180
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
reversible: false
is: SBO:0000176
modifier: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_0fec6138_8298_428c_b36d_04760953501b
is: SBO:0000252
name: RPIA
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:22934
initial amount: NaN
constant: false
is: P49247
has only substance units: false

metaR MMCDm
modifier: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
reversible: false
name: Methylmalonyl-CoA decarboxylase, mitochondrial
is described by: ECO:0000212
reactant: MODEL1310110037#
fast: false
type: Reaction
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.1.1.9
product: MODEL1310110037#

metaR LEUKTRF4t
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: leukotriene F4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110037#

metaM CE5101 m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
constant: false
is: CHEBI:57795

metaR GALSIDEtl
type: Reaction
name: galactocerebroside intracellular transport
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
reversible: true

metaM e4hglu m
initial amount: NaN
type: Species
is: SBO:0000247
name: erythro-4-hydroxy-L-glutamate(1-)
has only substance units: false
is: CHEBI:6331
initial concentration: 1.0
boundary condition: false
is: HMDB02273
constant: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947

metaR DM gpi sig er
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR MTHFD2m
reactant: MODEL1310110037#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
modifier: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000254

metaR SERDGLYexR
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110037#
fast: false
reversible: true
is: SBO:0000185
name: D-Serine/Glycine reversible exchange
reactant: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_1b820b5e_1719_4ded_9e15_695262cedd6a
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3948
has only substance units: false
initial amount: NaN
name: LDHC
initial concentration: NaN
type: Species
constant: false
is: P07864

metaR r2384
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110037#
is: SBO:0000185

metaR r1895
modifier: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false

metaM gsn c
is: SBO:0000247
is: C00387
boundary condition: false
name: Guanosine
constant: false
initial amount: NaN
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial concentration: 1.0
type: Species
is: HMDB00133
is: CHEBI:16750
has only substance units: false

metaM oaa m
is: SBO:0000247
name: Oxaloacetate
is: C00036
type: Species
initial amount: NaN
is: CHEBI:16452
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00223
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036

http://identifiers.org/biomodels.db/MODEL1310110037#_89dbf879_9eae_4387_b0d8_b88dd9303c27
name: ADH5
initial amount: NaN
is: SBO:0000252
is: Q6IRT1
has only substance units: false
boundary condition: true
is encoded by: hsa:128
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3fd2fa58_329f_4e3e_bdbf_fa067b01062f
initial concentration: NaN
boundary condition: true
type: Species
name: _D29675_1_e
is encoded by: hsa:D29675
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_a253b6b9_aea7_4cfa_8ec5_ebf078d12ebc
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:93183
is: SBO:0000252
type: Species
name: PIGM
constant: false
initial concentration: NaN
is: Q9H3S5

metaR KCCt
reactant: MODEL1310110037#
type: Reaction
reversible: true
modifier: MODEL1310110037#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
is: SBO:0000185
name: K+-Cl- cotransport
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM 6dhf e
type: Species
boundary condition: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: hexaglutamyl folate (DHF)
is: HMDB06563
constant: false

metaM tststerone e
initial concentration: 1.0
name: testosterone
boundary condition: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
is: CHEBI:17347
is: HMDB00234
is: SBO:0000247

metaM ppcoa c
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57392
name: Propanoyl-CoA
boundary condition: false
is: C00100
is: HMDB01275
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100

metaM gam c
constant: false
name: D-Glucosamine
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: HMDB01514
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:17315
is: SBO:0000247
initial amount: NaN
is: C00329

metaM dcholcoa c
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB06292
is: CHEBI:28701
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false

metaR r2407
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110037#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaR AMY2e
reversible: false
is described by: ECO:0000000
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
type: Reaction
name: alpha-amylase, extracellular (glygn2 -> glygn4)
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110037#

metaR RE3245C
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
type: Reaction
kinetic law: MODEL1310110037#
reversible: true
product: MODEL1310110037#
reactant: MODEL1310110037#
name: RE3245
is described by: ECO:0000000

metaM sphgn c
name: sphinganine(1+)
constant: false
initial concentration: 1.0
is: CHEBI:57817
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00269
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836

metaM thyox L c
initial concentration: 1.0
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial amount: NaN
is: HMDB00248
has only substance units: false
name: L-thyroxine
constant: false
is: CHEBI:18332
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_f82c4c37_df7d_4c02_90d0_a097e9cb73c7
is encoded by: hsa:284273
has only substance units: false
initial amount: NaN
name: ZADH2
boundary condition: true
initial concentration: NaN
is: Q4G1C4
constant: false
is: SBO:0000252
type: Species

metaR r0156
is version of: http://identifiers.org/ec-code/2.7.1.40
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
fast: false
product: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is: SBO:0000176

metaR ITCOAL1m
kinetic law: MODEL1310110037#
is: SBO:0000176
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is described by: ECO:0000304
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_0a9e3cac_3423_439d_9a90_2d3bdcb29c9e
boundary condition: true
is: P50053
constant: false
is: SBO:0000252
is encoded by: hsa:3795
initial amount: NaN
has only substance units: false
name: KHK
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_6a95d9df_6124_4274_9b14_3a1112f89304
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: AMY2B
is: P19961
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:280

http://identifiers.org/biomodels.db/MODEL1310110037#_72b8c14a_7dc8_4eef_a61e_1b2c1db765f6
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9P019
name: PHPT1
is: SBO:0000252
is encoded by: hsa:29085
has only substance units: false
type: Species

metaR C14STRr
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.3.1.70
name: C-14 sterol reductase
reversible: false
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000134
modifier: MODEL1310110037#

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR r2408
kinetic law: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110037#
reversible: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#

metaM mi14p c
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
constant: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: CHEBI:58282
is: HMDB00968
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

metaR NODe
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000185
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110037#
name: NODe
type: Reaction

metaM glyb c
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
type: Species
boundary condition: false
name: glycine betaine
has only substance units: false
initial amount: NaN
is: CHEBI:17750
is: HMDB00043
initial concentration: 1.0
is: SBO:0000247

metaM m2gacpail hs r
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
constant: false
has only substance units: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
initial amount: NaN
is: SBO:0000247
is: CHEBI:16038
initial concentration: 1.0
boundary condition: false

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM dhdascb c
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
name: dehydroascorbide(1-)
is: SBO:0000247
is: HMDB01264
is: CHEBI:58070
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_33e18472_c846_4327_a40a_7c3aa50cdc57
is encoded by: hsa:8879
is: O95470
boundary condition: true
name: SGPL1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

metaR r1667
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110037#
name: Y+LAT2 Utilized transport
product: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction

metaM CE4872 c
is: SBO:0000247
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: CHEBI:15748
constant: false
type: Species
is: HMDB00127
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR r2382
is: SBO:0000185
reactant: MODEL1310110037#
fast: false
reversible: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM C02528 c
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:36234
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
name: chenodeoxycholate
boundary condition: false
constant: false
is: HMDB00518
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_05a94730_22fe_4dc6_9680_8510ab16e452
constant: false
is encoded by: hsa:53354
boundary condition: true
name: PANK1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaM CE5117 m
constant: false
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
boundary condition: false
initial concentration: 1.0
is: HMDB00127
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:15748
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117

http://identifiers.org/biomodels.db/MODEL1310110037#_8860e745_2c69_4a45_9350_583aa66516c5
type: Species
has only substance units: false
is: Q9UHI5
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC7A8
initial concentration: NaN
is encoded by: hsa:23428

metaR CSNt
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000269
name: cytosine transport via facilated diffusion
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110037#
is: SBO:0000185
modifier: MODEL1310110037#
type: Reaction
reversible: true

metaM dd2coa m
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:57330
initial concentration: 1.0
boundary condition: false
name: trans-dodec-2-enoyl-CoA(4-)
is: HMDB03712
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_327066f2_4572_4d84_9ecc_67b84c352bc5
type: Species
constant: false
is: P49189
boundary condition: true
name: ALDH9A1
is encoded by: hsa:223
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r1666
product: MODEL1310110037#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_a96b87bd_5c90_4ad0_bce5_56777af5e87a
initial concentration: NaN
has only substance units: false
name: SLC29A2
is encoded by: hsa:3177
is: Q14542
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM cmp n
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
name: CMP(2-)
has only substance units: false
is: HMDB00095
boundary condition: false
type: Species
constant: false
initial amount: NaN

metaM clpn hs c
type: Species
has only substance units: false
notes: FORMULA: CHARGE: 0
initial concentration: 1.0
name: clpn_hs[c]
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00067
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_f2ca1df4_968e_4c80_aa70_d755d8b4670f
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:4522
name: MTHFD1
constant: false
initial concentration: NaN
is: SBO:0000252
is: P11586

metaR r1746
product: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110037#

metaR r1669
kinetic law: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true
type: Reaction
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaM 12ppd S c
constant: false
is: HMDB06213
boundary condition: false
type: Species
is: CHEBI:29002
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (S)-propane-1,2-diol
initial amount: NaN
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1

metaM C02528 e
is: CHEBI:36234
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: chenodeoxycholate
initial amount: NaN
type: Species
is: HMDB00518
has only substance units: false

metaM 5dhf e
is: HMDB06487
type: Species
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
has only substance units: false
initial amount: NaN
name: pentaglutamyl folate (DHF)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM co2 m
is: CHEBI:16526
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN
is: SBO:0000247
is: C00011
has only substance units: false
name: CO2
boundary condition: false
is: HMDB01967
initial concentration: 1.0
type: Species

metaM cmp m
constant: false
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
is: CHEBI:60377
has only substance units: false
boundary condition: false
is: HMDB00095
initial concentration: 1.0
type: Species
name: CMP(2-)

metaR r2380
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000185
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM hdca c
name: palmitate
initial amount: NaN
is: HMDB00220
constant: false
is: CHEBI:7896
boundary condition: false
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR EX 3ump LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-UMP(2-) exchange
type: Reaction

metaM xol7ah c
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: HMDB06892
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
boundary condition: false
is: CHEBI:2290

http://identifiers.org/biomodels.db/MODEL1310110037#_cc6299e2_23f2_4ce2_bc59_f923e58a31d2
initial concentration: NaN
constant: false
is: P00558
name: PGK1
is: SBO:0000252
type: Species
is encoded by: hsa:5230
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r1668
modifier: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_17c67d0e_add1_4a93_95a6_f3951f7f3e97
name: PPAP2A
is: G3XA95
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:8611
has only substance units: false

metaM uacgam c
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290

metaR 3MOX4HOXPGALDOX NADP
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
fast: false
type: Reaction
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
reversible: true
is described by: ECO:0000304
product: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR r1257
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110037#
reversible: false
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR r0434
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
is: SBO:0000176
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_844581fb_9844_42e1_b80a_dd969274e06f
is: P00441
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: SOD1
boundary condition: true
is encoded by: hsa:6647
has only substance units: false
initial concentration: NaN

metaR OCDCEAtr
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110037#_20979018_748c_4cb7_bf5f_d7fd643afbd8
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:1738
boundary condition: true
name: DLD
is: P09622
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_0ab1a521_584a_48c9_8e5a_433d30904444
is encoded by: hsa:91373
initial concentration: NaN
name: UAP1L1
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q3KQV9

metaR r0081
product: MODEL1310110037#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
kinetic law: MODEL1310110037#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
modifier: MODEL1310110037#
is: SBO:0000176

metaR ADA
is: SBO:0000176
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Adenosine deaminase
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
is described by: ECO:0000269
modifier: MODEL1310110037#
type: Reaction
product: MODEL1310110037#

metaM acetol c
initial amount: NaN
type: Species
is: HMDB06961
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:27957
constant: false
name: hydroxyacetone
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_4f2cbdbb_16ce_4ac0_adc0_95bd215edb8f
initial concentration: NaN
boundary condition: true
name: AADAT
is: Q4W5N8
is encoded by: hsa:51166
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaM pail45p hs c
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
is: CHEBI:28910
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
initial concentration: 1.0

metaR LNLCCPT2
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaM 13dampp c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: CHEBI:57484
type: Species
name: trimethylenediaminium
initial amount: NaN
constant: false
is: HMDB00002
boundary condition: false
is: SBO:0000247

metaR RE3556C
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3556
reversible: true
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110037#

metaM HC01403 m
name: (S)-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
constant: false
is: CHEBI:28325
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM 2mop m
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57700
has only substance units: false
type: Species
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0
is: HMDB01172
constant: false

metaM udpg c
is: HMDB00286
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: C00029
type: Species
has only substance units: false
is: CHEBI:58367
name: UDPglucose
initial concentration: 1.0
is: SBO:0000247

metaM tchola c
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00036
is: SBO:0000247
boundary condition: false
has only substance units: false
name: taurocholic acid
is: CHEBI:36257
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122

metaM 3mob m
is: CHEBI:11851
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00019
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

http://identifiers.org/biomodels.db/MODEL1310110037#_1b8ccdd8_ee9e_43dc_99e3_7fe3e0d5f1c4
is: SBO:0000252
is encoded by: hsa:6579
constant: false
type: Species
is: P46721
initial amount: NaN
initial concentration: NaN
name: SLCO1A2
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_2c983636_84ab_4e64_9ae5_9236b9660fd7
initial amount: NaN
constant: false
is encoded by: hsa:PRO1933
type: Species
name: _PRO1933_1_m
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_41a04f29_d202_4f8b_859e_553d70a9d7d7
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:51227
initial concentration: NaN
has only substance units: false
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false

metaM rbt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
is: SBO:0000247
name: D-ribitol
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:15963

metaR r0655
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110037#
type: Reaction
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_50de0553_2c92_4914_aac8_26939236d482
boundary condition: true
is: Q15181
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5464
initial concentration: NaN
name: PPA1
constant: false

metaR r0149
fast: false
type: Reaction
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110037#
reversible: true
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaM HC01434 m
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: oxalatosuccinate(3-)
boundary condition: false
type: Species
constant: false

metaR LNLCCPT1
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110037#

metaM pectindchac e
is: HMDB03402
name: pectin-deoxycholic acid complex
notes: FORMULA: C2559H3549O2539 CHARGE: -1
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM lnlc e
name: linoleate
initial concentration: 1.0
type: Species
is: CHEBI:30245
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00673
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false

metaR RNDR4
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110037#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (UDP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
type: Reaction
product: MODEL1310110037#

metaM dudp c
is: C01346
constant: false
is: HMDB01000
is: CHEBI:60471
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
name: dUDP
is: SBO:0000247

metaR CHOLtu
type: Reaction
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110037#
name: Choline uniport
kinetic law: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev

metaR GCC2cm
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_e7cad84c_45f1_43c6_ac66_160db8633a5a
initial concentration: NaN
initial amount: NaN
constant: false
is: A8DPS7
is encoded by: hsa:5049
has only substance units: false
boundary condition: true
name: PAFAH1B2
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_0cf03539_191c_4375_93cd_370c8e86205c
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P00439
name: PAH
is encoded by: hsa:5053
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR r0083
modifier: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000176
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.1.1.42

metaM dadp n
boundary condition: false
is: HMDB01508
name: dADP(3-)
is: CHEBI:57667
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
initial amount: NaN
type: Species

metaM 7thf e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: heptaglutamyl folate (THF)
boundary condition: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
is: SBO:0000247
is: HMDB06559
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_75bd3274_802a_42eb_93d6_1e59a31f93e0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q9Y6M9
is encoded by: hsa:4715
name: NDUFB9
constant: false

metaM ficytC m
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: CHEBI:15991
has only substance units: false
name: Ferricytochrome c
type: Species

metaM C02470 c
is: HMDB00881
is: C02470
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5485
is: SBO:0000247
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
constant: false
name: Xanthurenic acid
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_a9e1a3da_25e6_468e_a2c4_120272552209
name: BCKDHB
initial concentration: NaN
is encoded by: hsa:594
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is: P21953
initial amount: NaN

metaM acgam c
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:17411
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
constant: false
is: HMDB00215
name: N-acetyl-D-glucosamine
boundary condition: false
initial concentration: 1.0

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR GALt4
reactant: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
name: galactose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110037#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_391e5045_d779_45d4_b641_5bb2ef16ccae
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:221823
has only substance units: false
constant: false
boundary condition: true
name: PRPS1L1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_a06e7936_6579_4896_969c_506ede608775
is encoded by: hsa:80270
constant: false
type: Species
has only substance units: false
is: Q9H2F3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: HSD3B7

metaR RNDR3
reversible: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: ribonucleoside-diphosphate reductase (CDP)
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:

metaM 2mb2coa m
name: 2-methylcrotonoyl-CoA(4-)
is: HMDB02054
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial concentration: 1.0
is: CHEBI:57337
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR CAATPS
kinetic law: MODEL1310110037#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.6.3.8
name: Ca ATPase

http://identifiers.org/biomodels.db/MODEL1310110037#_b96fd691_4d0d_471e_bf67_51df3fa53ec3
name: PECR
is encoded by: hsa:55825
type: Species
is: Q9BY49
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r0870
fast: false
reversible: true
modifier: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/2.7.7.72
kinetic law: MODEL1310110037#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/3.1.3.4
name: Facilitated diffusion
product: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_a472d466_b55e_49ee_8938_3252ac6f790f
is encoded by: hsa:6506
is: P43004
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SLC1A2

metaR ADKd
modifier: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
name: adenylate kinase (d form)
type: Reaction
reactant: MODEL1310110037#
reversible: true

metaM 6a2ohxnt x
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:17534
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
name: 6-amino-2-oxohexanoic acid
is: HMDB12151

metaR TDCHOLAtx
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
fast: false
reversible: true
kinetic law: MODEL1310110037#
name: bile acid intracellular transport

metaM tchola e
constant: false
boundary condition: false
initial concentration: 1.0
name: taurocholic acid
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0
is: HMDB00036
type: Species
is: SBO:0000247
initial amount: NaN

metaR r0656
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110037#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is described by: ECO:0000000
reversible: false
product: MODEL1310110037#
fast: false

metaR r1749
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110037#
type: Reaction
is: SBO:0000185

metaM mercplaccys c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: HMDB06512
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
name: 3-mercaptolactate-cysteine disulfide

metaR r0082
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110037#
fast: false
is: SBO:0000176
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.6.1.2

metaR r1960
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#

metaM dadp m
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
name: dADP(3-)
is: CHEBI:57667

metaR NCKt
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
name: Na+/Ca2+-K+ exchange
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
type: Reaction
is described by: ECO:0000269

metaM dcsptn1coa c
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205483
is: HMDB06513
is: C16173
type: Species
initial amount: NaN

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM L2aadp m
initial concentration: 1.0
constant: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial amount: NaN
is: HMDB00510
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58672
name: L-2-aminoadipate(1-)
type: Species

metaR RNDR1
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (ADP)
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000254

metaM h2o2 m
is: SBO:0000247
type: Species
name: Hydrogen peroxide
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16240
is: HMDB03125
constant: false
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
has only substance units: false

metaM 44mctr r
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
type: Species
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:17813
is: HMDB01023
boundary condition: false
initial amount: NaN
has only substance units: false

metaR DESAT22 1p
reactant: MODEL1310110037#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110037#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
product: MODEL1310110037#

metaR AGTim
reversible: false
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
type: Reaction
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.44
is: SBO:0000176
reactant: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM lnlc c
initial concentration: 1.0
type: Species
is: CHEBI:30245
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
constant: false
is: HMDB00673
name: linoleate

metaR GGH 5DHFe
product: MODEL1310110037#
reactant: MODEL1310110037#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
modifier: MODEL1310110037#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110037#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_3bd682a2_31fb_4c8d_a541_452c6f60ff38
is encoded by: hsa:11181
initial amount: NaN
is: O43280
initial concentration: NaN
has only substance units: false
name: TREH
type: Species
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_de7cefb0_c81b_4a18_843e_90bc64d5f384
name: DGKZ
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8525
is: B7Z6M3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_af0b6120_482e_41d6_aa8b_d2b691aa35de
boundary condition: true
type: Species
is encoded by: hsa:84264
constant: false
name: HAGHL
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM chsterol e
has only substance units: false
constant: false
is: CHEBI:16113
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
name: cholesterol
boundary condition: false
initial amount: NaN

metaM nadp m
is: C00006
is: HMDB00217
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:58349

metaM orn m
is: HMDB00214
is: CHEBI:46912
initial amount: NaN
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
initial concentration: 1.0
name: Ornithine
is: C01602
type: Species
has only substance units: false
is: SBO:0000247

metaM itp c
name: ITP(3-)
is: SBO:0000247
is: CHEBI:57614
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00189
constant: false
type: Species
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0

metaR r0650
kinetic law: MODEL1310110037#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_eb85d64d_4329_4997_856f_f5c79c247de3
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q96I99
is encoded by: hsa:8801
initial amount: NaN
name: SUCLG2
has only substance units: false

metaR r0085
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
modifier: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.42

metaM dcholcoa r
constant: false
type: Species
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
is: CHEBI:28701
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_1aca665f_5c35_472a_98b4_94ef090ddf2f
is: SBO:0000252
is encoded by: hsa:5723
type: Species
name: PSPH
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: P78330
initial concentration: NaN

metaM h2o2 n
name: hydrogen peroxide
constant: false
is: CHEBI:16240
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: HMDB03125
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_6efba82c_6def_4589_94ba_6bf56d7e3b33
has only substance units: false
name: NT5C1B
is: B3KUK6
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:93034
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_12cff121_5cd3_4103_b69d_ed030ea6156e
constant: false
is encoded by: hsa:39
name: ACAT2
has only substance units: false
is: Q9BWD1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_0ef3a610_8a0b_4285_911e_4bcc1560d8e4
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:2678
is: P19440
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: GGT1

metaM gam e
is: HMDB01514
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00329
name: D-Glucosamine
constant: false
type: Species
is: CHEBI:17315
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
has only substance units: false

metaM lnlnca r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: alpha-linolenate
is: SBO:0000247
initial concentration: 1.0
is: HMDB01388
boundary condition: false
is: CHEBI:32387

metaR SPHS1Ptr
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
name: sphingosine-1-phosphate transport
reversible: true
is: SBO:0000185
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ

metaM gthrd c
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57925
is: HMDB00125
is: SBO:0000247
name: Reduced glutathione
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: C00051
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3badb316_0be9_400e_98cf_de660681d577
is encoded by: hsa:57468
initial amount: NaN
boundary condition: true
name: SLC12A5
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is: Q9H2X9

metaM leuktrD4 e
constant: false
is: HMDB03080
name: Leukotriene D4
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
boundary condition: false
is: CHEBI:28666
initial concentration: 1.0
initial amount: NaN

metaR KYNATESYN
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
type: Reaction
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
reversible: false
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176

metaR DUMPtn
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
fast: false
name: dUMP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r0145
is version of: http://identifiers.org/ec-code/1.8.3.1
reversible: true
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110037#

metaR RE3005M
reversible: true
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
fast: false
name: RE3005
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_f679e4af_0b0d_48aa_9bf8_aa90a3b48367
name: PLCXD2
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:257068
is: Q0VAA5
initial concentration: NaN

metaR r0651
is version of: http://identifiers.org/ec-code/1.5.1.2
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction
reversible: true
product: MODEL1310110037#
reactant: MODEL1310110037#

metaR CHATn
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
is described by: ECO:0000269
fast: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction

metaM glyc m
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial concentration: 1.0
is: HMDB00131
is: CHEBI:17754
is: C00116
name: Glycerol
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

metaM xol7aone r
initial concentration: 1.0
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_f8d94303_6b50_4bfb_a961_0ff34d49d062
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:765
has only substance units: false
type: Species
is: SBO:0000252
name: CA6
constant: false
is: Q5FC00

metaR THYOXt
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
modifier: MODEL1310110037#
name: T4 transport via bicarbonate countertransport
is described by: ECO:0000269

metaM C05957 r
constant: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
name: Prostaglandin J2
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:27485
boundary condition: false
is: HMDB02710
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_10a0b92e_c1b3_44c5_95e3_69bc9e9916d7
type: Species
constant: false
initial amount: NaN
name: MTMR1
is: Q13613
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8776
has only substance units: false

metaR FAOXC18480m
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Beta oxidation of fatty acid
reactant: MODEL1310110037#
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110037#

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_471d2983_a6dd_4482_870c_cb5fc8f64255
is: SBO:0000252
initial amount: NaN
is: Q96BD0
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: SLCO4A1
boundary condition: true
is encoded by: hsa:28231

http://identifiers.org/biomodels.db/MODEL1310110037#_a5803726_c632_4a1e_89dc_1687fad8f0bb
name: PGK2
is: SBO:0000252
type: Species
is encoded by: hsa:5232
is: P07205
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

metaR GLYCtm
is: SBO:0000185
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
name: glycerol transport
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
product: MODEL1310110037#

metaM mi14p n
has only substance units: false
constant: false
boundary condition: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58282
is: HMDB00968
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
type: Species
is: SBO:0000247

metaR SPHK21c
is described by: ECO:0000269
name: sphingosine kinase 2
is version of: http://identifiers.org/ec-code/2.7.1.91
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
modifier: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
is: SBO:0000176
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_28834e1c_b253_4628_ae54_ff7ebb7dbcdc
name: CHAT
constant: false
initial amount: NaN
type: Species
is: Q6LEN6
boundary condition: true
is encoded by: hsa:1103
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_54b27ca6_72aa_4602_a096_55bb8d277c78
is: Q8IYH3
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3036
type: Species
name: HAS1
is: SBO:0000252

metaR r0652
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaR CYSGLUexR
fast: false
is: SBO:0000185
name: L-cysteine/L-glutamine reversible exchanger
modifier: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000304
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_dedcfe6c_6917_4f3c_a9b1_7b5d5ff9a6d3
is: B3KT84
is encoded by: hsa:195814
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: SDR16C5
constant: false
boundary condition: true

metaR GALSIDEtg
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
name: galactocerebroside intracellular transport

metaM r5p c
is: SBO:0000247
is: C00117
type: Species
is: CHEBI:18189
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
name: alpha-D-Ribose 5-phosphate
initial amount: NaN
is: HMDB00618
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_9e8b8e2d_66ac_4160_89c1_7b0d648037ec
is encoded by: hsa:38
is: SBO:0000252
name: ACAT1
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: P24752

metaM fum c
is: SBO:0000247
is: CHEBI:29806
name: Fumarate
has only substance units: false
constant: false
is: HMDB00134
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3274d44f_de44_404e_89c1_4a206005a4f7
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P23786
type: Species
constant: false
name: CPT2
is: SBO:0000252
is encoded by: hsa:1376

http://identifiers.org/biomodels.db/MODEL1310110037#_27e2a9e1_e38c_4b6f_9365_8eb9d8eeefd2
is: SBO:0000252
constant: false
is: O60427
has only substance units: false
type: Species
is encoded by: hsa:3992
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: FADS1

metaM gthrd e
is: HMDB00125
name: glutathionate(1-)
is: CHEBI:57925
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
initial amount: NaN

metaM fol e
is: SBO:0000247
is: HMDB00121
has only substance units: false
boundary condition: false
name: Folate
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0

metaM gchola x
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: CHEBI:58235
is: HMDB00138
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_0ef877de_8993_429d_8208_5bf8a227559d
initial concentration: NaN
constant: false
name: PLCL1
initial amount: NaN
type: Species
has only substance units: false
is: Q15111
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5334

http://identifiers.org/biomodels.db/MODEL1310110037#_e975e48e_a9ed_4f3d_b8f7_4257219c9b4a
type: Species
constant: false
has only substance units: false
is encoded by: hsa:8875
name: VNN3:VNN2:VNN1
boundary condition: true
has part: A8K7W0
is encoded by: hsa:8876
is: SBO:0000297
has part: O95497
initial amount: NaN
is encoded by: hsa:55350
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_0249455a_93ed_4f81_8536_fe0e8dece1d2
is encoded by: hsa:218
initial concentration: NaN
name: ALDH3A1
type: Species
is: P30838
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR CYOOm3
reversible: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is version of: http://identifiers.org/ec-code/1.9.3.1
is described by: ECO:0000134
fast: false
name: cytochrome c oxidase, mitochondrial Complex IV
reactant: MODEL1310110037#

metaR r0653
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110037#

metaM 34hpp c
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247
initial amount: NaN
is: CHEBI:36242
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
has only substance units: false
constant: false
is: HMDB00707

metaR r0086
is described by: ECO:0000000
modifier: MODEL1310110037#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.3
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110037#
fast: false
type: Reaction
kinetic law: MODEL1310110037#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR GGH 5THFe
reversible: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false
reactant: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
name: Gamma-glutamyl hydrolase (5THF), extracellular
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110037#_56459918_b0d9_4577_8943_cbc4b9dfd9eb
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P54819
type: Species
name: AK2
initial amount: NaN
has only substance units: false
is encoded by: hsa:204

http://identifiers.org/biomodels.db/MODEL1310110037#_861b556a_2752_4585_bd96_3fb8a65a817f
initial amount: NaN
has only substance units: false
boundary condition: true
name: CPT2
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1376
is: P23786
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_54962e6d_4e2d_4ae3_9ab1_e5ba7972d7c1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:91703
initial amount: NaN
name: ACY3
has only substance units: false
is: Q96HD9
initial concentration: NaN
constant: false
type: Species

metaR VALt5m
fast: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Valine reversible mitochondrial transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#

metaR CHOLtn
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
name: Choline transport, nuclear through pores
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false

metaM HC02217 c
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
has only substance units: false
name: prostaglandin-g2
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM glu L e
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: CHEBI:29985
type: Species
is: HMDB00148
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: L-glutamate(1-)
boundary condition: false

metaR GALt1r
reversible: true
fast: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
name: galactose transport (uniport)
is: SBO:0000185
kinetic law: MODEL1310110037#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_32a346ba_0945_474b_88aa_cbbe98e00584
name: FDFT1
is: P37268
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2222
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_1b07f32c_3158_433e_b364_3da38080ddd4
has only substance units: false
is: SBO:0000252
name: CA1
initial concentration: NaN
is encoded by: hsa:759
is: P00915
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaR GLYtm
is: SBO:0000185
name: glycine passive transport to mitochondria
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_cf8f20a5_0827_4828_b4ef_ee3816bb1e1a
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AA532636
initial concentration: NaN
type: Species
name: _AA532636_1_m
boundary condition: true
is: SBO:0000252

metaR ORNt3m
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
modifier: MODEL1310110037#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
name: ornithine mitochondrial transport via proton antiport

http://identifiers.org/biomodels.db/MODEL1310110037#_1abcecf9_382c_4f16_addc_467e011d159e
initial amount: NaN
constant: false
has only substance units: false
name: SLC29A1
boundary condition: true
is: SBO:0000252
is: Q99808
is encoded by: hsa:2030
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_51ff1cf9_8ace_4621_894e_2da157b1d79f
initial concentration: NaN
initial amount: NaN
name: ADHFE1
has only substance units: false
boundary condition: true
type: Species
constant: false
is: Q8IWW8
is encoded by: hsa:137872
is: SBO:0000252

metaM dag hs e
is: CHEBI:18035
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_26f82c97_acc8_4409_a5a3_0539877aed7b
constant: false
has only substance units: false
is: Q16760
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8527
name: DGKD

metaM gpi sig r
is: CHEBI:58190
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: Y CHARGE: 0
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00224

metaR ILETA
kinetic law: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110037#
reactant: MODEL1310110037#
name: isoleucine transaminase
product: MODEL1310110037#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR ACALDt
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110037#
name: acetaldehyde reversible transport
reactant: MODEL1310110037#
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_df421575_2663_4e32_8eb7_7a7629c6a088
type: Species
initial concentration: NaN
name: SOD1
is encoded by: hsa:6647
is: P00441
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_f0594ac7_c7f9_4ed8_aa57_4eba13672f51
initial concentration: NaN
is encoded by: hsa:8525
is: SBO:0000252
is: B7Z2M9
has only substance units: false
boundary condition: true
name: DGKZ
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_fc9543ea_ab51_4c7a_993c_c959d8df320c
is: P54687
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: BCAT1
type: Species
initial concentration: NaN
is encoded by: hsa:586
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_47bc3529_de79_4745_bce8_106512e79d5b
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ATG9B
type: Species
is encoded by: hsa:285973
is: SBO:0000252
is: Q674R7
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_70f8e232_c3e5_4bc4_8943_1cd8ec0b181c
initial concentration: NaN
is encoded by: hsa:3632
initial amount: NaN
name: INPP5A
constant: false
is: Q14642
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

metaR r0365
reversible: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000176
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#

metaM 3mob c
type: Species
name: 3-methyl-2-oxobutanoate
is: HMDB00019
has only substance units: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:11851

metaM nh4 x
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00051
is: CHEBI:28938
name: Ammonium
is: C01342
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaM L2aadp c
name: L-2-aminoadipate(1-)
is: SBO:0000247
constant: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false
is: HMDB00510
initial concentration: 1.0
is: CHEBI:58672
boundary condition: false
type: Species
initial amount: NaN

metaM lnlnca l
initial concentration: 1.0
name: alpha-linolenate
initial amount: NaN
has only substance units: false
is: HMDB01388
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: CHEBI:32387
is: SBO:0000247
type: Species
boundary condition: false
constant: false

metaR TAGt
type: Reaction
name: triacylglycerol transport
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_a45ca3b8_0afa_432a_9199_f36b006ebaec
initial concentration: NaN
is encoded by: hsa:8560
type: Species
is: SBO:0000252
is: O15121
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: DEGS1

metaR GLCAASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110037#
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110037#
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110037#

metaR 3HBCOAHLm
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000000
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is: SBO:0000176
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reversible: false
fast: false
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_01a85e9b_82bc_4659_ada8_39c1768746da
constant: false
initial amount: NaN
has only substance units: false
name: PIGV
initial concentration: NaN
boundary condition: true
is: Q9NUD9
is: SBO:0000252
type: Species
is encoded by: hsa:55650

metaR r0983
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8

metaM leuktrD4 c
type: Species
has only substance units: false
is: HMDB03080
name: Leukotriene D4
initial concentration: 1.0
is: CHEBI:28666
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_bc21c121_1f11_4a0a_804a_1b7fb36110bd
has only substance units: false
is: SBO:0000252
is encoded by: hsa:38
initial amount: NaN
is: P24752
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: ACAT1

metaM HC02217 e
is: CHEBI:27647
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
type: Species
name: prostaglandin-g2
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM glu L c
has only substance units: false
name: L-glutamate(1-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
is: CHEBI:29985
type: Species
is: HMDB00148

metaM CE0713 m
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 3-oxolinoleoyl-CoA
has only substance units: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: HMDB02329
initial concentration: 1.0
is: CHEBI:30623

http://identifiers.org/biomodels.db/MODEL1310110037#_6335563a_281e_4275_8b08_275aa6343616
is: SBO:0000252
name: SLC37A4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2542
type: Species
constant: false
is: A8K0S7
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_3a457987_e28b_4788_9201_e1c2c399bd92
constant: false
initial concentration: NaN
is encoded by: hsa:55350
is: SBO:0000297
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: VNN3:VNN2:VNN1

metaR 34DHXMANDACOX
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is described by: ECO:0000269
type: Reaction
product: MODEL1310110037#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reversible: false

metaR r0364
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110037#
type: Reaction
fast: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: false
is: SBO:0000176

metaM 2mop c
is: SBO:0000247
name: 2-methyl-3-oxopropanoate
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57700
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial concentration: 1.0
is: HMDB01172
type: Species
boundary condition: false

metaM tdchola x
is: HMDB00951
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: taurochenodeoxycholate
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247
is: CHEBI:9407
type: Species

metaR CYTK1n
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176
modifier: MODEL1310110037#
reversible: true
product: MODEL1310110037#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR r1446
is: SBO:0000176
name: EC:1.3.3.6
is described by: ECO:0000000
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
reversible: false

metaM h2o2 c
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
name: Hydrogen peroxide
is: HMDB03125
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00027
initial concentration: 1.0
is: CHEBI:16240

metaM itp e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
is: CHEBI:57614
initial amount: NaN
boundary condition: false
is: HMDB00189

metaR 2DR1PP
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reversible: false
product: MODEL1310110037#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reactant: MODEL1310110037#

metaM 10fthf6glu l
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
name: 10-formyltetrahydrofolate-[Glu](6)
boundary condition: false

metaM dag hs c
initial amount: NaN
boundary condition: false
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_880bf0e1_d9ff_45eb_a9a3_22d82ed16685
has only substance units: false
boundary condition: true
is: P40394
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:131
name: ADH7
initial amount: NaN
is: SBO:0000252

metaR r0984
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000000
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110037#

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR MAN1PT2
modifier: MODEL1310110037#
product: MODEL1310110037#
name: mannose-1-phosphate guanylyltransferase (GDP)
kinetic law: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.13

metaR GLNS
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.1.1.15
is: SBO:0000176
is described by: ECO:0000254
fast: false
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110037#
name: glutamine synthetase
reversible: false
reactant: MODEL1310110037#
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_2bcfabff_3f99_44fa_a16b_710011fde80d
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4967
type: Species
constant: false
has part: B4E3E9
is: SBO:0000297
boundary condition: true
name: DLD:DLST:OGDH:PDHX

metaM HC01434 c
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:58931
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
is: SBO:0000247

metaM CE5162 r
has only substance units: false
is: HMDB00127
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:15748
constant: false
name: trans,cis-2,9-octadecadienoyl-CoA
initial concentration: 1.0
is: SBO:0000247

metaM dhap x
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57642
boundary condition: false
type: Species
is: HMDB01473
initial amount: NaN
name: Dihydroxyacetone phosphate
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411
is: C00111

metaM nicrnt c
is: C01185
boundary condition: false
is: CHEBI:57502
type: Species
has only substance units: false
constant: false
name: Nicotinate D-ribonucleotide
initial amount: NaN
initial concentration: 1.0
is: HMDB01132
is: SBO:0000247
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185

http://identifiers.org/biomodels.db/MODEL1310110037#_a73e7250_2f25_48a0_9da1_e3c3ee0e7087
initial concentration: NaN
is encoded by: hsa:6240
has only substance units: false
is: SBO:0000252
type: Species
name: RRM1
boundary condition: true
is: P23921
constant: false
initial amount: NaN

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_6ecbf3ce_89f8_4022_9b50_17e93430b2e8
constant: false
has only substance units: false
is encoded by: hsa:122622
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: ADSSL1
initial concentration: NaN
is: Q8N142

http://identifiers.org/biomodels.db/MODEL1310110037#_4a987649_c4ec_4061_9734_d2d3e3300257
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: Q8TCT0
is encoded by: hsa:64781
has only substance units: false
name: CERK

http://identifiers.org/biomodels.db/MODEL1310110037#_d5eea44b_422a_4ec4_9dca_b01d2ec302ad
boundary condition: true
initial amount: NaN
is encoded by: hsa:AU149534
name: _AU149534_1_c
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species

metaM chsterol r
initial amount: NaN
is: CHEBI:16113
name: cholesterol
boundary condition: false
has only substance units: false
is: HMDB00067
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_8b04020f_6764_419c_b4c0_4aac8c8d84a4
constant: false
is: Q8TBG4
type: Species
is encoded by: hsa:64850
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: AGXT2L1
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_9c636500_9241_4192_abd8_f49a12d15076
initial concentration: NaN
constant: false
is encoded by: hsa:1757
is: A8K596
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: SARDH
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_df809ff2_2503_44a1_9a6e_13bb6c191a0f
is encoded by: hsa:122481
boundary condition: true
initial amount: NaN
constant: false
name: AK7
is: Q96M32
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false

metaM nadp r
is: CHEBI:58349
is: C00006
constant: false
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
is: HMDB00217
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR CYTK1m
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
fast: false
is: SBO:0000176
reactant: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
name: cytidylate kinase (CMP),mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110037#_6bd8149a_2ee2_4e38_b71f_2b345376b802
type: Species
is encoded by: hsa:2639
name: GCDH
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN

metaM pac c
boundary condition: false
constant: false
has only substance units: false
name: phenylacetate
is: SBO:0000247
is: HMDB00209
is: CHEBI:18401
initial amount: NaN
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial concentration: 1.0
type: Species

metaM asp D c
is: CHEBI:29990
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB06483
name: D-aspartate(1-)
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1

metaM glyc c
name: Glycerol
is: HMDB00131
is: CHEBI:17754
initial concentration: 1.0
is: C00116
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_76f566cd_361b_4a1a_aa65_9a2b003a0ed8
boundary condition: true
is encoded by: hsa:28232
constant: false
is: Q9UIG8
type: Species
name: SLCO3A1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_5c7f235b_b4c7_4577_9212_5f834207e73e
initial amount: NaN
is: P11310
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:34
name: ACADM
is: SBO:0000252
constant: false

metaR CYSTA
fast: false
product: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
reversible: true
reactant: MODEL1310110037#
is described by: ECO:0000304
name: cysteine transaminase
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176

metaM h2o2 e
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
initial amount: NaN
name: hydrogen peroxide
is: HMDB03125
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:16240

http://identifiers.org/biomodels.db/MODEL1310110037#_c0585970_1a5e_46e1_94d9_e6286343e6be
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _U52111_1_c
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:U52111

metaM pmtcoa x
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01338
is: C00154
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: CHEBI:57379
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)

metaM orn e
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1
boundary condition: false
is: CHEBI:0
has only substance units: false
name: Ornithine
constant: false
initial amount: NaN
is: SBO:0000247
is: C01602
is: HMDB00214
initial concentration: 1.0

metaM chsterol m
name: cholesterol
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16113

http://identifiers.org/biomodels.db/MODEL1310110037#_6af5300e_6b52_4919_8356_e012359f1e62
initial concentration: NaN
name: GPT2
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84706
type: Species
initial amount: NaN
is: Q8TD30

metaR TCHOLAtx
is: SBO:0000185
fast: false
name: bile acid intracellular transport
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_364b25f2_1acf_4030_8152_91c8a8b4838a
name: DPYD
type: Species
is: Q12882
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:1806

metaM dtdp n
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_64604a8c_7812_403d_83fe_215ee589e99e
is: P36269
type: Species
constant: false
name: GGT5
is encoded by: hsa:2687
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaM lac D c
is: CHEBI:16004
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
name: (R)-lactate
has only substance units: false
type: Species
is: HMDB01311
constant: false
is: SBO:0000247
boundary condition: false

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_d033f090_d600_4b56_a19c_2fd25fd3b757
is: Q6ZMR3
is encoded by: hsa:160287
initial concentration: NaN
is: SBO:0000252
name: LDHAL6A
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_93407225_1e31_47bd_8cd4_a439f6315078
type: Species
is encoded by: hsa:W74642
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: _W74642_1_c
initial amount: NaN

metaR RE3567C
product: MODEL1310110037#
name: RE3567
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110037#
reversible: true
fast: false
kinetic law: MODEL1310110037#
type: Reaction

metaR PRO Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
reversible: true
name: D-proline transport, extracellular
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false

metaM rib D c
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: D-ribose
is: HMDB00283
is: CHEBI:16988
boundary condition: false

metaM 10fthf6glu m
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](6)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_242e49d3_da59_4385_9983_c800c9f43648
is: Q96CA6
has only substance units: false
is: SBO:0000252
is encoded by: hsa:30
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: ACAA1
initial amount: NaN

metaR r0591
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
reactant: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110037#
reversible: true

metaM glyc e
name: Glycerol
is: CHEBI:17754
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_9e741f00_9bc8_4b1d_8a39_a99bc9321c38
boundary condition: true
name: GPX4
has only substance units: false
constant: false
is encoded by: hsa:2879
is: P36969
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaM chsterol l
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
is: CHEBI:16113
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00067
constant: false
type: Species

metaM asp D e
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06483
is: CHEBI:29990
name: D-aspartate(1-)
boundary condition: false

metaM dcholcoa x
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
constant: false
is: CHEBI:28701
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB06292

metaM gthrd m
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
constant: false
name: glutathionate(1-)
is: HMDB00125
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaM coa c
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: SBO:0000247
is: C00010
name: Coenzyme A
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:3312
is: HMDB01423
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_8a4daf7c_f203_4e8f_97f7_ca1ed304dace
initial concentration: NaN
is encoded by: hsa:8854
name: ALDH1A2
type: Species
is: F5H2Y9
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_fb161fcf_a5ce_480c_8189_32ef64de0451
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q6IBA0
name: NDUFS5
initial amount: NaN
type: Species
is encoded by: hsa:4725

metaR UMPK5n
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110037#
fast: false
name: UMP kinase (dATP),nuclear
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110037#
type: Reaction
reversible: true

metaR r0590
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reversible: false
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110037#

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000134
fast: false
product: MODEL1310110037#
is: SBO:0000185
reversible: true
name: Transport of (R)-Pantothenate
type: Reaction

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM orn c
is: C01602
boundary condition: false
type: Species
has only substance units: false
is: HMDB00214
name: Ornithine
is: CHEBI:0
constant: false
initial amount: NaN
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial concentration: 1.0
is: SBO:0000247

metaM rib D e
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
is: HMDB00283
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: CHEBI:16988
name: D-ribose
has only substance units: false

metaM CE2432 m
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
constant: false
initial amount: NaN
is: CHEBI:57795
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_ef9e9ece_e5ef_412f_9271_364d21f09524
initial concentration: NaN
is: Q8TDQ7
constant: false
is encoded by: hsa:132789
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: GNPDA2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_c2ce81fb_b1a5_43e5_8ef0_8e0ee8a20e09
initial amount: NaN
name: AKR1B1
is encoded by: hsa:231
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P15121

metaR ACONTm
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is: SBO:0000176
reactant: MODEL1310110037#
name: Aconitate hydratase
kinetic law: MODEL1310110037#
is described by: ECO:0000134
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110037#
product: MODEL1310110037#
fast: false

metaR NDPK7n
product: MODEL1310110037#
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110037#_3c65b561_7a15_488e_acc5_e6774739e4f9
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:29920
initial concentration: NaN
name: PYCR2
type: Species
constant: false
is: Q96C36
boundary condition: true

metaR 34DHXMANDACOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is: SBO:0000176
reversible: true
product: MODEL1310110037#
reactant: MODEL1310110037#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase

metaR GLNtN1
name: Glutamine transport (Na, H coupled)
is described by: ECO:0000269
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
fast: false
type: Reaction
reactant: MODEL1310110037#
reversible: true

metaM fol m
initial concentration: 1.0
is: CHEBI:27470
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: Folate
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
is: HMDB00121
type: Species

metaM hdca r
is: CHEBI:7896
boundary condition: false
type: Species
is: C00249
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: Hexadecanoate (n-C16:0)

metaR RE1573M
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
kinetic law: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
reactant: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
name: RE1573
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8

http://identifiers.org/biomodels.db/MODEL1310110037#_c702b0de_103a_4c4d_8ccf_243cc875e6f0
name: SLC25A11
is: F5GY65
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8402
initial concentration: NaN
boundary condition: true
constant: false

metaR NTD4
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
reactant: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
name: 5'-nucleotidase (CMP)
notes: GENE_ASSOCIATION: (51251.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:11795870 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaM 3mob e
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0
is: CHEBI:11851
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: SBO:0000247
is: HMDB00019

metaR DNDPt22m
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000269
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
product: MODEL1310110037#
name: dTDP transport via dUDP antiport

metaR GLYtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110037#
name: glycine passive transport to peroxisome
type: Reaction
kinetic law: MODEL1310110037#

metaM rbt c
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15963
name: D-ribitol
constant: false
type: Species

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM pyr m
is: SBO:0000247
is: CHEBI:15361
boundary condition: false
constant: false
is: C00022
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species
name: pyruvate
initial amount: NaN
has only substance units: false
is: HMDB00243
is: http://identifiers.org/pubchem.compound/3324

metaM 3hibutcoa m
name: (S)-3-Hydroxyisobutyryl-CoA
is: HMDB01052
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:28259
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaM dolp L c
boundary condition: false
is: CHEBI:57683
is: SBO:0000247
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR EX pectindchac LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-deoxycholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_8ba42998_25c3_4b37_bc96_8410c3ae9da4
is encoded by: hsa:55349
constant: false
is: Q8NE62
name: CHDH
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_fc1c1b72_307c_4e37_aa83_4b1151bdc9f4
is encoded by: hsa:55577
constant: false
initial concentration: NaN
initial amount: NaN
name: NAGK
type: Species
is: Q9UJ70
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r2376
reversible: true
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
product: MODEL1310110037#

metaR r0276
type: Reaction
kinetic law: MODEL1310110037#
fast: false
product: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is: SBO:0000176
is described by: ECO:0000000

metaR CHOLATEt
type: Reaction
is: SBO:0000185
name: cholate transport via bicarbonate countertransport
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110037#
fast: false
product: MODEL1310110037#

metaM nadh m
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
is: C00004
initial amount: NaN
is: HMDB01487
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_5078df25_8ca8_4c36_bc7f_d50766e9ec2e
initial concentration: NaN
constant: false
type: Species
name: NME1
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4830

metaM CE1944 c
constant: false
boundary condition: false
is: CHEBI:36781
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
initial concentration: 1.0
type: Species
initial amount: NaN
name: 1-pyrrolinium

metaR r2439
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_c53af65d_d6a7_499a_8968_ec4d67c9ec82
is: SBO:0000252
name: _AI926493_1_c
initial concentration: NaN
constant: false
is encoded by: hsa:AI926493
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

metaR PROt2r
reversible: true
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
name: L-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110037#_7b66e110_9ac4_438d_bde6_1bb3699717fa
initial concentration: NaN
boundary condition: true
is: A8K7W0
is encoded by: hsa:8875
type: Species
name: VNN2
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaM lnlnca c
is: CHEBI:32387
type: Species
is: SBO:0000247
boundary condition: false
constant: false
name: alpha-linolenate
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
initial amount: NaN
is: HMDB01388
initial concentration: 1.0

metaM orot c
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: C00295
is: HMDB00226
type: Species
constant: false
initial amount: NaN
is: CHEBI:30839
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Orotate

http://identifiers.org/biomodels.db/MODEL1310110037#_f0c1306d_9408_4dee_b571_dc405a3c0a48
constant: false
name: _AA629629_1_m
type: Species
is encoded by: hsa:AA629629
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR LDH L
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
reversible: true
is: SBO:0000176
product: MODEL1310110037#
type: Reaction
name: L-lactate dehydrogenase
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_a5a955bd_1d60_4623_9733_e4478617292e
is encoded by: hsa:43
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: ACHE
initial concentration: NaN
type: Species
is: P22303

metaM ha pre1 e
name: hyaluronan biosynthesis, precursor 1
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
constant: false
is: CHEBI:16126
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN

metaR r0384
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110037#
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
product: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
is described by: ECO:0000000

metaM sarcs c
constant: false
is: C00213
is: CHEBI:3513
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0
boundary condition: false
name: Sarcosine
initial concentration: 1.0
has only substance units: false
is: HMDB00271
type: Species
initial amount: NaN

metaR FAOXC2252053m
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110037#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110037#
type: Reaction
name: Beta oxidation of long chain fatty acid
product: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaR r0999
product: MODEL1310110037#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR r2375
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_7363f674_f8fd_42f1_b77e_93cd090c4456
name: CS
boundary condition: true
type: Species
is: O75390
is encoded by: hsa:1431
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_48cb3cb8_a283_4c8f_afbd_b788c3e90ed4
initial amount: NaN
type: Species
name: PKLR
is encoded by: hsa:5313
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false

metaR LPCOXp
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110037#
name: L-pipecolate oxidase, peroxisomal
is version of: http://identifiers.org/ec-code/1.5.3.1
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_df3ef058_6741_4cdc_bea8_413efe6e953b
is: SBO:0000252
name: SLC3A2
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6520
is: P08195
boundary condition: true
initial amount: NaN
constant: false

metaR ASPDTDe
fast: false
name: D-aspartate transport, extracellular
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
kinetic law: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_3a75c1b2_5484_496f_a9bd_54976a1304d9
is: P33316
name: DUT
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1854
boundary condition: true

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR r0385
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
type: Reaction
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_d17691a1_e97a_40dc_93cb_6679434e6e43
is: SBO:0000252
constant: false
name: TKT
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:7086
has only substance units: false
is: E7EPA7
boundary condition: true

metaR r2378
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#

metaM HC01444 e
type: Species
initial amount: NaN
name: Galactosylglycerol
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: CHEBI:15754
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_a36a4bd6_d1d5_489b_8f4a_21822eee7aa9
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:641371
name: ACOT1
has only substance units: false
initial concentration: NaN
is: E9KL42
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_51facde8_53b5_48a9_978b_390d04242ac9
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:6536
name: SLC6A9
is: SBO:0000252
type: Species
initial amount: NaN
is: P48067

metaR r0998
reversible: true
fast: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110037#
type: Reaction
name: Facilitated diffusion
kinetic law: MODEL1310110037#
is: SBO:0000185

metaR SMPD4
reactant: MODEL1310110037#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
is: SBO:0000176
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: sphingomyelinase
type: Reaction

metaR r1549
is: SBO:0000185
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
fast: false
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR HAS2
name: hyaluronan synthase
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.4.1.212
is described by: ECO:0000269
kinetic law: MODEL1310110037#
fast: false

metaR r0517
reversible: true
is: SBO:0000176
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110037#
fast: false

metaR CMPSAS
is version of: http://identifiers.org/ec-code/2.7.7.43
is: SBO:0000176
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reactant: MODEL1310110037#
fast: false
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: CMP sialic acid synthase
modifier: MODEL1310110037#
reversible: false
is described by: ECO:0000304

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_c969eff7_d7c6_4c3b_b29f_6d5fd976ca69
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P60891
type: Species
is encoded by: hsa:5631
name: PRPS1

metaR r0386
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
reversible: false
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000176

metaM dctp c
is: CHEBI:16311
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
constant: false
initial amount: NaN
boundary condition: false
is: C00458
initial concentration: 1.0
is: HMDB00998
name: dCTP

metaR r0908
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
name: Postulated transport reaction
kinetic law: MODEL1310110037#

metaR MANt1r
type: Reaction
modifier: MODEL1310110037#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
name: mannose transport (uniport)
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
kinetic law: MODEL1310110037#

metaR r2377
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110037#_deb3e82a_119d_49ff_9764_6bfd8245c439
constant: false
type: Species
initial concentration: NaN
name: ELOVL4
is: SBO:0000252
is: Q9GZR5
boundary condition: true
initial amount: NaN
is encoded by: hsa:6785
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_da657763_055f_43e5_a57f_2ed63f42b5f9
is: P31645
is encoded by: hsa:6532
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: SLC6A4

metaR DAGt
fast: false
is described by: ECO:0000269
name: diacylglycerol transport
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
reversible: true

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM methf c
is: HMDB01354
type: Species
is: CHEBI:57455
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 5,10-Methenyltetrahydrofolate
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_c38be632_009b_4a21_94b6_b4196a03cce3
name: _AI971036_1_m
is encoded by: hsa:AI971036
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaM 10fthf7glu l
type: Species
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: 10-formyltetrahydrofolate-[Glu](7)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_31dd023b_5b47_429f_8af3_553d3f324f09
boundary condition: true
name: _AF080579_1_c
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:AF080579
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_1d6e0a57_914f_4d76_8fcc_05589fa0a69a
initial amount: NaN
type: Species
is encoded by: hsa:AU149534
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: _AU149534_1_e

metaR EX strch1 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_3409e969_3c0f_4d17_9e23_ed4f538d6520
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:M68895
boundary condition: true
name: _M68895_1_c
type: Species
is: SBO:0000252
constant: false

metaR r1548
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false

metaR r1653
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false

metaR TCYNTtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
is: SBO:0000185
reversible: false
name: Thiocyanate transport via diffusion (mitochondrial)
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR RE0453C
product: MODEL1310110037#
name: RE0453
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_d28f91ca_23f5_429c_8d9c_18b7114980f0
is encoded by: hsa:4830
has only substance units: false
name: NME1
initial concentration: NaN
is: P15531
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_926c3de7_fd7f_48e4_ae46_b7df0309becb
has only substance units: false
initial concentration: NaN
is: O14521
boundary condition: true
is encoded by: hsa:6392
initial amount: NaN
is: SBO:0000252
type: Species
name: SDHD
constant: false

metaR H4ETer
kinetic law: MODEL1310110037#
is: SBO:0000176
reversible: false
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum
is described by: ECO:0000000
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
reactant: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_517bc95d_edd2_42f7_87c0_da04b9926b97
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:219
has only substance units: false
type: Species
boundary condition: true
is: P30837
name: ALDH1B1

metaR r0909
product: MODEL1310110037#
reversible: true
fast: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_5a7a594a_9215_4987_8e57_04605cb385ed
is encoded by: hsa:11112
initial amount: NaN
has only substance units: false
is: P31937
initial concentration: NaN
name: HIBADH
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaM mi145p c
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
has only substance units: false
is: CHEBI:203600
is: SBO:0000247
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: HMDB01498
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_15c8c0cf_9f38_4da1_8ec6_19efe23811db
name: SLC23A1
is encoded by: hsa:9963
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaR r1815
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110037#
is described by: ECO:0000000
reversible: false
product: MODEL1310110037#

metaR r1928
product: MODEL1310110037#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaM 42A3HP24DB c
is: HMDB04083
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: C05645
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: SBO:0000247
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: http://identifiers.org/pubchem.compound/7956
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_0bbc6477_4017_4c0e_8d84_ca66fa9cbe9b
initial concentration: NaN
name: DGKI
initial amount: NaN
type: Species
is encoded by: hsa:9162
has only substance units: false
is: SBO:0000252
constant: false
is: O75912
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_b5992e48_19c5_45ca_bebb_8c95880b998e
initial amount: NaN
is: P23743
constant: false
type: Species
is encoded by: hsa:1606
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: DGKA
has only substance units: false

metaR r1866
type: Reaction
modifier: MODEL1310110037#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
is: SBO:0000185
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_0a2a2427_689b_4bb3_bb22_732a4642546c
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:51227
name: PIGP
has only substance units: false
constant: false

metaM man e
boundary condition: false
is: CHEBI:16024
is: SBO:0000247
name: D-Mannose
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
is: C00159
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_31c896be_f062_47ea_9d51_98cffbd8c0e7
initial concentration: NaN
is: Q15392
constant: false
has only substance units: false
is encoded by: hsa:1718
name: DHCR24
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_3ae6bcc0_6405_458c_9c9c_89ad48f32c32
has only substance units: false
boundary condition: true
is encoded by: hsa:2880
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: O75715
constant: false
name: GPX5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_b38a225f_fcf0_4bf3_84cb_136c58e59683
is: O94788
is encoded by: hsa:8854
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: ALDH1A2
constant: false
has only substance units: false
initial concentration: NaN

metaR r1547
is: SBO:0000185
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
fast: false
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 4mop c
has only substance units: false
constant: false
initial amount: NaN
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865
is: SBO:0000247
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
type: Species
boundary condition: false
initial concentration: 1.0

metaR r2379
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true

metaR RDH3a
is version of: http://identifiers.org/ec-code/1.1.1.105
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is described by: ECO:0000269
name: retinol dehydrogenase (11-cis,NADPH)
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110037#

metaR r1652
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110037#

metaM udpg r
is: CHEBI:58367
has only substance units: false
type: Species
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00286
constant: false
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029

metaR r0160
reversible: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.1.3.2
reactant: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110037#
fast: false
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR r0594
product: MODEL1310110037#
fast: false
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM 10fthf c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
is: CHEBI:57454
has only substance units: false
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00972
initial amount: NaN
is: C00234
is: SBO:0000247

metaR RE3624M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE3624
reversible: false
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
fast: false

metaM ak2lgchol hs e
initial amount: NaN
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6975
boundary condition: false
is: C04317
constant: false
type: Species
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317

http://identifiers.org/biomodels.db/MODEL1310110037#_c81f438e_8e72_487b_b61f_bc4c0e193c69
has only substance units: false
boundary condition: true
type: Species
name: _AA614647_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA614647

metaR DM dgpi prot hs r
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_72de649d_141e_4891_8371_647121ae00fd
is encoded by: hsa:AI090874
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: _AI090874_1_c
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_74a6feb0_64a1_414d_a26b_ab765ae8dce4
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q99999
is: SBO:0000252
initial concentration: NaN
type: Species
name: GAL3ST1
is encoded by: hsa:9514

metaR HISSNAT5tc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r0514
is described by: ECO:0000000
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
reversible: false
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
is: SBO:0000176

metaM pro L c
is: HMDB00162
has only substance units: false
name: L-proline
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
constant: false
type: Species
is: CHEBI:17203
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_b96462b4_9eee_4a58_881a_9fc0f750ae80
is: SBO:0000252
boundary condition: true
is: Q9BQG2
constant: false
is encoded by: hsa:83594
type: Species
initial concentration: NaN
initial amount: NaN
name: NUDT12
has only substance units: false

metaR RE2659R
name: RE2659
fast: false
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110037#
reversible: true

metaR DCMPDA
reactant: MODEL1310110037#
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110037#
name: dCMP deaminase
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.12
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is described by: ECO:0000254

metaR r1651
modifier: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r1546
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reversible: true

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_4be585a0_7ba5_494f_aa02_b99467a30391
constant: false
is: P37287
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5277
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PIGA
type: Species

metaR PRPPS
kinetic law: MODEL1310110037#
reversible: true
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000176
name: phosphoribosylpyrophosphate synthetase
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.6.1
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
fast: false

metaR r1865
type: Reaction
is: SBO:0000185
reactant: MODEL1310110037#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110037#
reversible: false
fast: false
modifier: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_ecdf23c9_5cf9_4e40_bf36_16e417c9dcc6
name: PANK1
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:53354
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM 10fthf7glu m
notes: FORMULA: C50H57N13O25 CHARGE: -8
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](7)
is: SBO:0000247
constant: false

metaM arg L c
constant: false
type: Species
name: L-argininium(1+)
is: SBO:0000247
is: HMDB00517
has only substance units: false
boundary condition: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_526b9263_6a95_457a_ad46_6828e6a25613
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: Q8TEQ8
has only substance units: false
is encoded by: hsa:84720
boundary condition: true
name: PIGO
is: SBO:0000252

metaR O2t
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
name: o2 transport (diffusion)
kinetic law: MODEL1310110037#
product: MODEL1310110037#

metaM 4mop e
type: Species
is: HMDB00695
name: 4-methyl-2-oxopentanoate
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r1650
is described by: ECO:0000000
reversible: true
product: MODEL1310110037#
reactant: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000185

metaM lnlnca e
initial concentration: 1.0
name: alpha-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:32387
initial amount: NaN
is: HMDB01388
is: SBO:0000247
constant: false

metaM orot e
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226
name: orotate
is: CHEBI:30839
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_07f8ee3d_c2b7_4744_8293_38ef9831e1d9
is: P24311
is encoded by: hsa:1349
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: COX7B
has only substance units: false
initial concentration: NaN
type: Species

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR r0596
kinetic law: MODEL1310110037#
fast: false
product: MODEL1310110037#
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
is: SBO:0000176
modifier: MODEL1310110037#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_df5896a4_7b9a_40ea_97ae_27adda53ad47
initial concentration: NaN
name: PAFAH2
is encoded by: hsa:5051
is: Q99487
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

metaM tmndnccoa m
name: timnodonyl coenzyme A
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
boundary condition: false
is: HMDB06514
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_dd3b0ede_b2f1_4bf2_9ed6_411509beec34
constant: false
is: SBO:0000252
is: O00767
has only substance units: false
is encoded by: hsa:6319
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: SCD

http://identifiers.org/biomodels.db/MODEL1310110037#_6661fb80_7a85_4f49_85bc_ff6ffaafb04c
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GLRX2
is encoded by: hsa:51022
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_313c3f8c_36ff_42bf_a888_9d0a757cafb8
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:64077
has only substance units: false
name: LHPP
is: Q9H008
type: Species
constant: false
is: SBO:0000252

metaR r1544
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
reversible: true

metaR DHFtm
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
fast: false
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: dihydrofolate reversible mitochondrial transport

http://identifiers.org/biomodels.db/MODEL1310110037#_e5abbb51_216c_4cf5_bac6_fd1cb694fda3
name: ALDH1B1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:219
type: Species
is: P30837
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM dudp m
type: Species
has only substance units: false
name: dUDP(3-)
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:60471
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0

metaM bilglcur c
is: CHEBI:57767
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110037#_442608ce_d4b8_4d0a_992d_29366809c961
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: _NM_001929_1_c
constant: false
boundary condition: true
is encoded by: hsa:NM 001929
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_4159f7c7_1f1d_413f_805c_4ea5df43fbf2
is: P47989
name: XDH
is encoded by: hsa:7498
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaM pro L e
has only substance units: false
boundary condition: false
name: L-proline
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
is: HMDB00162
constant: false
is: CHEBI:17203

metaR r1657
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_76fee094_7793_4a08_818a_e9247fcde1fc
initial concentration: NaN
is encoded by: hsa:5743
name: PTGS2
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P35354

http://identifiers.org/biomodels.db/MODEL1310110037#_c631b0ef_7c61_4069_bef8_57da33a516ec
name: ME1
is: P48163
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:4199
boundary condition: true

metaM h2o2 x
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
is: CHEBI:16240
name: Hydrogen peroxide
type: Species
is: C00027
is: HMDB03125
initial concentration: 1.0
has only substance units: false

metaM dudp n
is: HMDB01000
is: SBO:0000247
name: dUDP(3-)
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

metaM no c
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
constant: false
is: SBO:0000247
is: C00533
initial amount: NaN
boundary condition: false
type: Species
name: Nitric oxide
initial concentration: 1.0
is: CHEBI:16480
has only substance units: false

metaM 4ppcys m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial concentration: 1.0
constant: false
type: Species
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial amount: NaN
is: HMDB01117
boundary condition: false
is: CHEBI:59458

metaM h e
has only substance units: false
type: Species
is: CHEBI:24636
boundary condition: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton

metaR r1656
fast: false
modifier: MODEL1310110037#
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: true

metaR PIt8
reversible: true
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
type: Reaction
kinetic law: MODEL1310110037#
name: phosphate transport in/out via Na+ symporter
product: MODEL1310110037#
is described by: ECO:0000006
reactant: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
is: SBO:0000185

metaM oxa m
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB02329
type: Species
is: CHEBI:30623
name: oxalate(2-)
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_0f493510_92df_4966_b009_92d22e4dd4ce
has only substance units: false
type: Species
is: Q9NRF8
is: SBO:0000252
initial concentration: NaN
constant: false
name: CTPS2
boundary condition: true
initial amount: NaN
is encoded by: hsa:56474

http://identifiers.org/biomodels.db/MODEL1310110037#_04396297_0c05_4d05_b349_0c9a71c124d1
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:AI697028
initial concentration: NaN
name: _AI697028_1_m
is: SBO:0000252

metaM 20ahchsterol m
is: SBO:0000247
initial amount: NaN
is: HMDB06283
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
name: 20-hydroxycholesterol
boundary condition: false
is: CHEBI:1296
has only substance units: false
constant: false
initial concentration: 1.0
type: Species

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_d94c7a89_3675_4e51_86a9_9aa859be48f7
is: P49902
is encoded by: hsa:22978
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: NT5C2
constant: false

metaM arg L e
is: HMDB00517
is: CHEBI:32682
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
is: SBO:0000247

metaR r1757
product: MODEL1310110037#
fast: false
type: Reaction
modifier: MODEL1310110037#
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaR GK1
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.8
name: guanylate kinase (GMP:ATP)
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110037#

metaR LNLNCGt
reversible: true
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185

metaR RE0453N
is: SBO:0000176
product: MODEL1310110037#
is described by: ECO:0000000
name: RE0453
reactant: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
type: Reaction
kinetic law: MODEL1310110037#
fast: false

metaR LDH D
is version of: http://identifiers.org/ec-code/1.1.2.4
type: Reaction
modifier: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
fast: false
product: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
name: D-lactate dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110037#_a82802d3_3428_4232_baf4_e9bda01cf6f1
initial concentration: NaN
constant: false
is encoded by: hsa:1103
initial amount: NaN
is: P28329
boundary condition: true
is: SBO:0000252
has only substance units: false
name: CHAT
type: Species

metaM thcholstoic c
is: SBO:0000247
boundary condition: false
is: HMDB03873
has only substance units: false
constant: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
initial amount: NaN

metaR r1655
is described by: ECO:0000000
reversible: true
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
type: Reaction
fast: false

metaR r0845
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
reactant: MODEL1310110037#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
product: MODEL1310110037#
type: Reaction

metaR PIt7
type: Reaction
name: phosphate transport in/out via three Na+ symporter
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is: SBO:0000185
reactant: MODEL1310110037#
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_7f654f82_04df_4750_8581_36cad9c58b37
initial amount: NaN
type: Species
is: P27708
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:790
name: CAD
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_0619a576_b690_4f29_8ceb_8b040340cfcb
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q9NUB1
constant: false
has only substance units: false
boundary condition: true
name: ACSS1
is encoded by: hsa:84532
type: Species

metaM gacpail hs c
has only substance units: false
is: CHEBI:61548
initial amount: NaN
boundary condition: false
is: C00092
is: HMDB01401
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
name: glucosaminyl-acylphosphatidylinositol

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_6369e98f_bb09_43cd_9200_4b1f2a39ff8b
initial amount: NaN
type: Species
name: OGDH
boundary condition: true
has only substance units: false
is: Q02218
constant: false
is encoded by: hsa:4967
initial concentration: NaN
is: SBO:0000252

metaM bilglcur e
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

http://identifiers.org/biomodels.db/MODEL1310110037#_7e32396c_7de5_429b_873f_464ed53010f8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9380
name: GRHPR
is: Q9UBQ7
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM ak2lgchol hs c
is: C04317
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/6975
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial concentration: 1.0
is: SBO:0000247

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_720070c4_0648_4cc9_9b5d_dc3fdc7b4f03
type: Species
initial concentration: NaN
name: PANK2
constant: false
has only substance units: false
is encoded by: hsa:80025
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q6P1K9

metaR r1654
modifier: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#

metaM h g
type: Species
is: CHEBI:24636
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: proton

metaM 4mlacac c
boundary condition: false
name: 4-maleylacetoacetate
type: Species
is: CHEBI:17105
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02052
initial amount: NaN
has only substance units: false

metaM no e
constant: false
is: HMDB03378
is: SBO:0000247
has only substance units: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: C00533
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:16480
name: Nitric oxide
initial concentration: 1.0

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

metaR O2St
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (extracellular)
fast: false
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_0f5c654e_93dd_4927_a33f_3454d62dcb97
boundary condition: true
has only substance units: false
name: ZADH2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:284273
constant: false
is: Q8N4Q0
type: Species
initial amount: NaN

metaM C05965 e
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB04243
type: Species
constant: false
name: 12(S)-HPETE(1-)
is: CHEBI:57444
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
boundary condition: false
initial concentration: 1.0

metaR r1922
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#

metaM hco3 m
is: HMDB00595
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Bicarbonate
type: Species
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
boundary condition: false
constant: false
is: C00288

http://identifiers.org/biomodels.db/MODEL1310110037#_bf782cf0_e8a1_48b5_a355_42a3b82a0ec9
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10005
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: O14734
initial amount: NaN
name: ACOT8

metaR r1540
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
reversible: false
is: SBO:0000185
modifier: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
fast: false

metaM fru c
is: HMDB00660
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: CHEBI:15824
is: C00095
name: D-Fructose
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species

metaM mmcoa S m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57327
is: HMDB02310
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
boundary condition: false
name: (S)-methylmalonyl-CoA(5-)
has only substance units: false
constant: false
type: Species

metaR r2372
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM CE4794 m
has only substance units: false
is: CHEBI:15748
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00127
initial amount: NaN
name: cis-6-dodecenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110037#_c0b463f0_605f_4c52_878e_b6565ba1edb2
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:53354
constant: false
type: Species
is: Q8TE04
boundary condition: true
name: PANK1

http://identifiers.org/biomodels.db/MODEL1310110037#_4c9289d1_1ac6_4711_b76f_9ea8e108caac
type: Species
has only substance units: false
boundary condition: true
is: B3KNC1
is encoded by: hsa:51733
constant: false
initial amount: NaN
name: UPB1
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_2784fa04_a28f_4c13_b510_bcf248ef4128
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _AI601100_1_m
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:AI601100
is: SBO:0000252

metaM maltttr e
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/5141
is: SBO:0000247
is: HMDB01296
name: Maltotetraose
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
boundary condition: false
is: C02052
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR r0403
is version of: http://identifiers.org/ec-code/1.2.4.4
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaR r0629
kinetic law: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.4.1
is version of: http://identifiers.org/ec-code/3.6.1.22
reactant: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_ee33bbc9_c8b2_4a2c_bca5_2983886a6421
is: Q9BYZ2
is: SBO:0000252
type: Species
boundary condition: true
name: LDHAL6B
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:92483

metaR CYANt
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
reversible: true
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
type: Reaction
name: Cyanide transport via diffusion (extracellular to cytosol)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_e946dbb7_d1b7_4fb3_aef0_7649632e5563
name: PIGH
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5283
is: Q14442
boundary condition: true
type: Species

metaM akg m
boundary condition: false
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
name: 2-Oxoglutarate
constant: false
initial amount: NaN
is: SBO:0000247
is: C00026
is: HMDB00208
type: Species
is: CHEBI:16810

metaR PI4PLC
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110037#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
name: phosphatidylinositol 4-phosphate phospholipase C
reversible: false

metaR r2371
kinetic law: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110037#
reversible: true
is described by: ECO:0000000

metaR FRDPtcr
reactant: MODEL1310110037#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.

metaR r1979
is described by: ECO:0000000
reactant: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110037#
type: Reaction

metaR ARACHt
reactant: MODEL1310110037#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: fatty acid transport via diffusion
is: SBO:0000185

metaM thr L c
is: SBO:0000247
is: CHEBI:16857
boundary condition: false
constant: false
has only substance units: false
name: L-threonine
initial amount: NaN
is: HMDB00167
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial concentration: 1.0

metaM fru e
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15824
is: C00095
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
constant: false
is: HMDB00660
has only substance units: false
is: SBO:0000247
type: Species
name: D-Fructose

metaR GPIAT
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
modifier: MODEL1310110037#
product: MODEL1310110037#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
name: glucosaminylphosphatidyl inositol acetyltransferase

http://identifiers.org/biomodels.db/MODEL1310110037#_da1b0f50_1aa8_4f4b_a402_f60c5d9272e7
is: SBO:0000252
is: Q549M5
name: NDUFC2
initial amount: NaN
is encoded by: hsa:4718
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_bc982ab9_9946_46e5_b8d9_b944cd78a7c1
boundary condition: true
is encoded by: hsa:AI697028
is: SBO:0000252
initial amount: NaN
constant: false
name: _AI697028_1_e
initial concentration: NaN
has only substance units: false
type: Species

metaR ME2
reactant: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.40
name: malic enzyme (NADP)
fast: false
modifier: MODEL1310110037#
reversible: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r0842
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.1.72
reactant: MODEL1310110037#
name: Postulated transport reaction
fast: false
product: MODEL1310110037#
modifier: MODEL1310110037#
reversible: true
is described by: ECO:0000000
type: Reaction

metaM 10fthf7glu c
initial amount: NaN
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](7)
notes: FORMULA: C50H57N13O25 CHARGE: -8
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR CO2ter
fast: false
kinetic law: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110037#
name: CO2 endoplasmic reticular transport via diffusion
reactant: MODEL1310110037#

metaM gua c
is: CHEBI:16235
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C00242
constant: false
name: Guanine
is: HMDB00132
boundary condition: false
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial amount: NaN

metaR MANt4
reversible: true
modifier: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000269
is: SBO:0000185
fast: false
name: D-mannose transport via sodium cotransport

metaR r0494
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_848cbf8a_284d_4e92_8e9c_fae77e3f4995
is encoded by: hsa:57127
initial amount: NaN
type: Species
is: SBO:0000252
name: RHBG
is: Q9H310
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaR INSt
modifier: MODEL1310110037#
fast: false
product: MODEL1310110037#
is described by: ECO:0000269
name: Inosine transport (diffusion)
is: SBO:0000185
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
reversible: true
kinetic law: MODEL1310110037#

metaR r2374
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110037#
fast: false
product: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaM arg L m
type: Species
initial concentration: 1.0
is: CHEBI:32682
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
is: HMDB00517
constant: false
name: L-argininium(1+)

metaM prpncoa m
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: acryloyl-CoA(4-)
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: SBO:0000247
is: CHEBI:57367
is: HMDB02307
initial amount: NaN
boundary condition: false

metaR MMSAD3m
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.27
reversible: false
reactant: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_3f9e0c77_400b_46cc_9377_53a4e23094c1
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA788780
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _AA788780_1_c

metaR r0627
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
is: SBO:0000176
kinetic law: MODEL1310110037#
fast: false

metaM dctp n
is: SBO:0000247
has only substance units: false
is: HMDB00998
type: Species
boundary condition: false
name: dCTP
constant: false
initial amount: NaN
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311
initial concentration: 1.0
is: C00458

http://identifiers.org/biomodels.db/MODEL1310110037#_3e915cd1_7415_4cd6_8a0d_49f0866a487b
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P31350
is encoded by: hsa:6241
initial concentration: NaN
name: RRM2

metaR DM anth
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_90865355_4dab_40fb_a499_95f29108bd3e
constant: false
type: Species
has only substance units: false
name: SLC2A9
is encoded by: hsa:56606
is: SBO:0000252
initial amount: NaN
is: Q9NRM0
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_01482efc_0350_4847_adcb_2280728e0b6b
name: VNN3
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:55350
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaM acmana r
is: SBO:0000247
has only substance units: false
is: HMDB01129
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:17122
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
name: N-acetyl-D-mannosamine
boundary condition: false

metaR r1659
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM h c
constant: false
name: proton
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: SBO:0000247
is: CHEBI:24636
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00080
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "

metaM HC02180 c
is: CHEBI:28728
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
name: thromboxane-b2
has only substance units: false
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM methf m
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57455
is: HMDB01354
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
type: Species
constant: false
name: (6R)-5,10-methenyltetrahydrofolate

metaR r0166
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false

metaM lgt S c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: (R)-S-lactoylglutathionate(1-)
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
is: CHEBI:57474
is: HMDB01066
boundary condition: false
constant: false
initial amount: NaN
type: Species

metaM nadh c
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00004
is: CHEBI:57945

http://identifiers.org/biomodels.db/MODEL1310110037#_6c675b91_eeb4_48dd_a391_4e76996672c4
has only substance units: false
name: ATP2B2
boundary condition: true
is: SBO:0000252
type: Species
is: Q4J699
constant: false
is encoded by: hsa:491
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_a4f4f730_e9a3_4ab0_96f0_4b7e27a2aa58
is: SBO:0000252
is: Q969K7
is encoded by: hsa:113452
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
name: TMEM54
constant: false

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR NDPK10n
fast: false
reactant: MODEL1310110037#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is described by: ECO:0000304

metaR r0400
fast: false
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is: SBO:0000176
reactant: MODEL1310110037#
reversible: true

metaR r2373
reactant: MODEL1310110037#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true

metaR RE1836X
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
name: RE1836
reversible: true
product: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000176

metaM sarcs m
is: SBO:0000247
has only substance units: false
is: CHEBI:15611
is: HMDB00271
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: C00213
type: Species
name: Sarcosine
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r1658
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM 4mop m
is: CHEBI:17865
name: 4-methyl-2-oxopentanoate
boundary condition: false
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: HMDB00695
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

metaM 10fthf7glu e
constant: false
is: HMDB00108
boundary condition: false
name: 10-formyltetrahydrofolate-[Glu](7)
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: CHEBI:16236
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM strdnccoa m
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205473
constant: false
is: HMDB06519
is: C16163
boundary condition: false
has only substance units: false
name: stearidonyl coenzyme A
type: Species
is: SBO:0000247

metaM thr L e
boundary condition: false
initial amount: NaN
is: HMDB00167
has only substance units: false
name: L-threonine
type: Species
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial concentration: 1.0
constant: false
is: CHEBI:16857

metaR H3MTer U
modifier: MODEL1310110037#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: H3 mannosyltransferase, endoplasmic reticulum
fast: false
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_efeb16b7_97c5_4841_ab8c_2f83dcd39e16
name: PTGDS
boundary condition: true
is: P41222
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:5730
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_9e41da44_5b9d_4185_b2ca_0ba47260d19b
constant: false
is: SBO:0000252
name: _BE966236_1_c
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:BE966236
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_2eab6756_6ed3_46d2_a4d5_48036e78157f
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM ca2 c
initial concentration: 1.0
is: HMDB00464
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: calcium(2+)
is: CHEBI:29108
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR ARAB Lt
product: MODEL1310110037#
name: L-arabinoase extracellular transport
reactant: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_bfd30995_f0a3_47a4_b31b_a9c7634e4a9d
type: Species
is: SBO:0000252
name: COX6A1
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P12074
is encoded by: hsa:1337
has only substance units: false
constant: false

metaR UMPK5
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dATP)
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is: SBO:0000176

metaR FAOXC204
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
modifier: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaM tststerone r
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
is: HMDB00234
initial amount: NaN
type: Species
initial concentration: 1.0
name: testosterone
is: SBO:0000247
is: CHEBI:17347
constant: false

metaR r0051
type: Reaction
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110037#
reversible: true
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is: SBO:0000176

metaM prostgh2 c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57405
is: HMDB01381
name: prostaglandin H2(1-)
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN

metaR r2140
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110037#
reversible: true
product: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_2fcb8813_8e4f_4f85_85e9_a005e130df19
name: _AV727634_1_c
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AV727634
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM HC02180 e
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: thromboxane-b2
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: SBO:0000247
is: CHEBI:28728
boundary condition: false

metaM pro L m
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:17203
constant: false
has only substance units: false
name: L-proline
initial concentration: 1.0

metaR CDS
is: SBO:0000176
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.41
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
name: phosphatidate cytidylyltransferase
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#

metaR UMPK6
kinetic law: MODEL1310110037#
is: SBO:0000176
name: UMP kinase (dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
fast: false
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000269

metaR r1976
product: MODEL1310110037#
name: Y+LAT2 Utilized transport
fast: false
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#

metaR r0407
kinetic law: MODEL1310110037#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
reversible: true
product: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.4.3.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_64cbe14e_b4c1_4cbb_a9fb_fa5566add5c3
is encoded by: hsa:5092
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PCBD1
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_7a08a5b8_2583_4914_8d43_feac8854db9f
initial amount: NaN
name: NDUFB5
constant: false
is: O43674
type: Species
has only substance units: false
is encoded by: hsa:4711
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_4d536d4c_1fce_4f7a_9f0f_add935a54dcd
name: SUCLA2
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is: E5KS60
boundary condition: true
is encoded by: hsa:8803
has only substance units: false
initial amount: NaN

metaR ASNNm
reversible: false
fast: false
product: MODEL1310110037#
name: L-asparaginase (mitochondrial)
modifier: MODEL1310110037#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.1
reactant: MODEL1310110037#
is described by: ECO:0000254
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm

metaM etoh e
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
has only substance units: false
is: HMDB00108
type: Species
is: CHEBI:16236
constant: false
name: ethanol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_45eba44b_fc03_4566_bd4e_6e0762456bdf
constant: false
is encoded by: hsa:AI971036
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: _AI971036_1_c

metaR GLYBt4 2 r
product: MODEL1310110037#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110037#
is: SBO:0000185
type: Reaction
name: Betaine transport (sodium symport) (2:1)
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false

metaM CE2421 m
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB02329
constant: false
is: SBO:0000247
name: (3S)-3-hydroxylinoleoyl-CoA
is: CHEBI:30623

metaR GGH 7DHFe
reactant: MODEL1310110037#
is described by: ECO:0000000
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
is: SBO:0000176
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR UMPK7
name: UMP kinase (dGTP)
is described by: ECO:0000269
modifier: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
fast: false

metaR CO2tm
is described by: ECO:0000000
name: CO2 transport (diffusion), mitochondrial
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR SADT
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25

metaM prostgh2 e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
has only substance units: false
is: SBO:0000247
name: prostaglandin H2(1-)
is: CHEBI:57405
is: HMDB01381
initial amount: NaN
type: Species

metaM HC01603 c
initial concentration: 1.0
notes: FORMULA: C40H45N11O19 CHARGE: -6
name: 10-formyltetrahydrofolate-[Glu](5)
is: HMDB00067
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaR RETI1
is: SBO:0000176
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
name: retinol isomerase (11-cis)
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_6739df7e_d7e6_4337_a25b_6fe9aec4d718
constant: false
is: SBO:0000252
is encoded by: hsa:AA419122
type: Species
initial amount: NaN
name: _AA419122_1_c
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_3440fea3_3ae7_4074_a7cf_7b1b551faff9
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:55350
name: VNN3

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_05961175_599b_4e3f_a466_903e7ea4e362
name: SLC27A2
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: O14975
constant: false
is: SBO:0000252
is encoded by: hsa:11001

http://identifiers.org/biomodels.db/MODEL1310110037#_262949be_445d_4dbb_a788_44dc462af80d
initial amount: NaN
boundary condition: true
is: P49902
name: NT5C2
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:22978

http://identifiers.org/biomodels.db/MODEL1310110037#_fb4a732c_1b96_4706_a2d8_d6f3d623d75c
is encoded by: hsa:284111
constant: false
has only substance units: false
type: Species
name: SLC13A5
is: Q86YT5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_1d18d294_8672_4d0f_ade7_5cd4c203223f
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:8527
is: SBO:0000252
constant: false
name: DGKD
initial amount: NaN
type: Species

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_47f693ca_e8b2_4124_b549_310fc5f58b83
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: _AW299740_1_m
has only substance units: false
is encoded by: hsa:AW299740

metaR RE0915E
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000176
reactant: MODEL1310110037#
name: RE0915
product: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
fast: false

metaR r0157
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reversible: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.3.4.2
reactant: MODEL1310110037#
fast: false
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_dbb0a217_29fa_4afe_b727_d945b1e56a24
has only substance units: false
initial amount: NaN
is encoded by: hsa:6574
initial concentration: NaN
type: Species
is: Q8WUM9
boundary condition: true
name: SLC20A1
is: SBO:0000252
constant: false

metaM etoh c
constant: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00108
type: Species
name: ethanol
is: CHEBI:16236
initial concentration: 1.0
boundary condition: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR CHOLESTle
modifier: MODEL1310110037#
product: MODEL1310110037#
name: hydrolysis of cholesterol ester by cholesterol esterase
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.13
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: false
type: Reaction
is described by: ECO:0000134

metaM HC01407 m
has only substance units: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
boundary condition: false
type: Species
constant: false
name: (S)-Hydroxyhexanoyl-CoA
is: CHEBI:28276
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR ACACT10m
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reactant: MODEL1310110037#
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110037#
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
modifier: MODEL1310110037#
reversible: true

metaR GPIMTer U
modifier: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
kinetic law: MODEL1310110037#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
reversible: false
type: Reaction
is described by: ECO:0000000

metaM dolp U c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57683
boundary condition: false
type: Species
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
has only substance units: false

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaR ASNt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110037#
type: Reaction
name: L-asparagine transport in via sodium symport
modifier: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185

metaM udp c
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00295
name: UDP
has only substance units: false
initial amount: NaN
is: CHEBI:58223
is: C00015
is: SBO:0000247
constant: false

metaM nadh x
is: C00004
has only substance units: false
is: SBO:0000247
is: CHEBI:57945
is: HMDB01487
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide - reduced
type: Species
constant: false
initial amount: NaN

metaR LPS2e
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: lipase, extracellular
type: Reaction
modifier: MODEL1310110037#
reversible: false
is: SBO:0000176
product: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ

metaR FAEL204
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
type: Reaction
name: fatty-acyl-CoA elongation (n-C20:4CoA)
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ

metaR RE2079R
fast: false
name: RE2079
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_2e664391_fa90_49f0_b53d_db665d4ecb52
initial amount: NaN
is: Q9H0P0
constant: false
initial concentration: NaN
is: SBO:0000252
name: NT5C3
type: Species
is encoded by: hsa:51251
has only substance units: false
boundary condition: true

metaM 3mox4hoxm c
is: CHEBI:27622
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: 3-Methoxy-4-hydroxymandelate
constant: false
is: HMDB00291
is: SBO:0000247
has only substance units: false

metaR NACASPtm
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
is described by: ECO:0000000
fast: false
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)

http://identifiers.org/biomodels.db/MODEL1310110037#_e42f3c14_1cbc_451d_b6ad_872b367db9ab
name: SLC12A4
constant: false
boundary condition: true
type: Species
is encoded by: hsa:6560
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: F5H066

metaR UMPK2
modifier: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
name: UMP kinase (CTP)
reversible: true

metaM hco3 e
is: SBO:0000247
boundary condition: false
is: HMDB00595
initial concentration: 1.0
has only substance units: false
is: CHEBI:17544
initial amount: NaN
name: Bicarbonate
type: Species
is: C00288
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaM L2aadp6sa c
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01263
name: L-allysine
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false
is: CHEBI:17917
type: Species
is: SBO:0000247
initial amount: NaN

metaR r0408
reversible: true
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.4.3.5
type: Reaction
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is: SBO:0000176
reactant: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_b85cdbf3_bd58_4e7e_99e6_54144d384253
is: P04075
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:226
initial amount: NaN
boundary condition: true
name: ALDOA

metaM CE4790 m
constant: false
has only substance units: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: HMDB00127
is: SBO:0000247
is: CHEBI:15748
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM aacoa m
is: HMDB01484
boundary condition: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
is: CHEBI:57286
has only substance units: false
name: acetoacetyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM sphs1p r
is: CHEBI:60119
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00277
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
type: Species

metaR UMPK3
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110037#
type: Reaction
name: UMP kinase (UTP)
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_1c85e890_b421_49fe_9f34_60fe0c8fd8ef
constant: false
has only substance units: false
is: P14854
boundary condition: true
is encoded by: hsa:1340
initial amount: NaN
name: COX6B1
initial concentration: NaN
type: Species
is: SBO:0000252

metaM m2emgacpail hs r
is: C00080
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: CHEBI:24636
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/3380

metaR KHK2
product: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
is: SBO:0000176
name: ketohexokinase (D-xylulose)
reactant: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.3
reversible: false
is described by: ECO:0000269
type: Reaction

metaM ca2 e
is: HMDB00464
initial concentration: 1.0
constant: false
is: CHEBI:29108
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: calcium(2+)

metaR r2142
is: SBO:0000185
modifier: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
fast: false

metaM pep c
boundary condition: false
name: Phosphoenolpyruvate
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: CHEBI:18021
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: C00074
has only substance units: false
is: HMDB00263
initial concentration: 1.0

metaM co2 r
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16526
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
name: CO2
initial concentration: 1.0
boundary condition: false
is: HMDB01967
is: C00011

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_8a3fe608_b6a0_4cfe_8d48_fceb60b104c8
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q5QPH3
is: SBO:0000252
is encoded by: hsa:55902
constant: false
name: ACSS2
has only substance units: false
type: Species

metaR DNDPt34m
modifier: MODEL1310110037#
reversible: false
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dTDP antiport
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR TSULt4 3
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
name: thiosulfate transport via sodium symport
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
reversible: true
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_06887008_98d2_47f7_8a24_fd9f74747a50
initial amount: NaN
is: SBO:0000297
has part: P43034
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5048
has only substance units: false
name: PAFAH1B1:PAFAH1B2:PAFAH1B3
constant: false
type: Species

metaM mlthf c
is: SBO:0000247
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: CHEBI:15636
is: HMDB01533
is: C00143
constant: false
type: Species
boundary condition: false
has only substance units: false
name: 5,10-Methylenetetrahydrofolate
initial concentration: 1.0
initial amount: NaN

metaR UMPK4
is described by: ECO:0000269
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110037#
type: Reaction
fast: false
name: UMP kinase (GTP)
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176

metaM hco3 c
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00595
is: CHEBI:17544
is: C00288
has only substance units: false
name: Bicarbonate

http://identifiers.org/biomodels.db/MODEL1310110037#_06070c5d_c868_4125_93fe_29797d96ec75
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: P16152
is encoded by: hsa:873
boundary condition: true
has only substance units: false
name: CBR1

http://identifiers.org/biomodels.db/MODEL1310110037#_739a4013_9b5b_4dad_b638_d332ff984261
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q6ZWP6
name: ACAD8
constant: false
is encoded by: hsa:27034
initial amount: NaN
type: Species

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaR r2141
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR DAG HSter
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: diacylglycerol ER export
reversible: false
kinetic law: MODEL1310110037#

metaR CYTK10n
is: SBO:0000176
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (CMP,dGTP),nuclear
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110037#
fast: false

metaR RE2972M
reversible: true
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.67
is described by: ECO:0000000
modifier: MODEL1310110037#
name: RE2972
type: Reaction

metaR RE3242R
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110037#
type: Reaction
reversible: true
kinetic law: MODEL1310110037#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: RE3242
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR ASPt6
product: MODEL1310110037#
name: L-aspartate transport via Na, H symport and K antiport
reversible: false
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185

metaR 5HLTDL
product: MODEL1310110037#
modifier: MODEL1310110037#
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
fast: false
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000269

metaR LNLCt
reversible: true
name: Linoleic acid (n-C18:2) transport in via diffusion
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR H2O2tp
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
name: hydrogen peroxide peroxisomal transport via diffusion
reversible: true
fast: false
product: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_5c0601e8_9894_48bb_ac8f_83c565d67176
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: P38571
is encoded by: hsa:3988
name: LIPA
initial amount: NaN

metaR r2443
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
fast: false

metaM cyan m
type: Species
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial amount: NaN
has only substance units: false
is: HMDB02084
is: CHEBI:18407
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_d5dbbd31_e40e_4f03_9678_a3ad5c8cc977
boundary condition: true
initial concentration: NaN
name: NME7
is: Q9Y5B8
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:29922
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_2652c961_b82b_4e51_bbb6_9479d2b89320
has only substance units: false
is: SBO:0000252
is: Q546Y9
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:57379
name: AICDA
boundary condition: true
type: Species
constant: false

metaR URIt5le
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
name: uridine transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_10059f93_7331_444f_bf9a_70714a3e6236
is encoded by: hsa:4329
name: ALDH6A1
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q02252

metaR RE3050R
kinetic law: MODEL1310110037#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
name: RE3050
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false

metaM damp c
is: CHEBI:58245
is: HMDB00905
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
has only substance units: false
type: Species
boundary condition: false
name: dAMP(2-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_f3d03f9a_65a9_46af_ab0f_23ebc7402d97
initial amount: NaN
name: HSD17B10
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:3028
is: Q99714
is: SBO:0000252

metaR r0512
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
fast: false
modifier: MODEL1310110037#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
product: MODEL1310110037#
reversible: true
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000176
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_f9b0e2e1_ec0b_454c_8a60_f25e3b225b88
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:2639
name: GCDH
type: Species
constant: false
is: Q92947
is: SBO:0000252
has only substance units: false

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaM thp2c c
type: Species
is: HMDB12130
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16987
initial amount: NaN
name: 1-piperideine-6-carboxylate
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450

http://identifiers.org/biomodels.db/MODEL1310110037#_6acada6f_283d_4d31_a79b_14e03255ac63
initial concentration: NaN
is encoded by: hsa:5277
is: B3KUV7
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: PIGA
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_11b4c67b_e860_4c79_bed1_47c484db4d04
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ACSL5
is: SBO:0000252
is: Q9ULC5
constant: false
is encoded by: hsa:51703
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_d5656f1a_f55a_4205_8227_83da4cbdcfae
boundary condition: true
has part: P31040
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6390
has part: P21912
is: SBO:0000297
has part: Q99643
is encoded by: hsa:6391
initial amount: NaN
constant: false
has part: O14521
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6389
type: Species
is encoded by: hsa:6392

http://identifiers.org/biomodels.db/MODEL1310110037#_2b39a16f_9ec2_4ab5_8dc9_113405452d9a
constant: false
is: SBO:0000252
is: Q8N9L9
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: ACOT4
is encoded by: hsa:122970
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_f66f12ac_c5e7_4c70_8696_3fd5d8befd88
name: PYCR1
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: A6NFM2
initial concentration: NaN
is encoded by: hsa:5831

metaR DCSPTN1COAtx
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM pyr e
constant: false
name: pyruvate
initial concentration: 1.0
type: Species
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR NDPK10
reversible: true
kinetic law: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:dIDP)
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR VALTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
name: valine transaminase, mitochondiral
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is: SBO:0000176
reversible: true
product: MODEL1310110037#
fast: false

metaR C204CPT2
fast: false
modifier: MODEL1310110037#
product: MODEL1310110037#
name: arachidonic acid transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
type: Reaction
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_cb8858d8_c617_42a2_b3a6_5f068b83c392
name: SUCLG1
boundary condition: true
is encoded by: hsa:8802
is: P53597
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM 44mzym r
has only substance units: false
name: 14-demethyllanosterol
boundary condition: false
constant: false
is: CHEBI:18364
initial concentration: 1.0
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial amount: NaN
is: HMDB01286
is: SBO:0000247
type: Species

metaM C02528 r
is: CHEBI:36234
name: chenodeoxycholate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
boundary condition: false

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM man1p c
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06330
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: CHEBI:35374

metaM udp r
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: CHEBI:58223
is: SBO:0000247
is: HMDB00295
constant: false
boundary condition: false
name: UDP
has only substance units: false
is: C00015
initial concentration: 1.0

metaR H2O2tn
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
name: hydrogen peroxide nuclear transport
is: SBO:0000185
fast: false

metaM man c
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
boundary condition: false
type: Species
has only substance units: false
is: C00159
initial amount: NaN
constant: false
is: SBO:0000247
name: D-Mannose
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_7ba8a3e5_af2e_4cbb_b624_8e619c84b180
is encoded by: hsa:51079
is: Q9P0J0
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFA13

metaR ENO
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP
is described by: ECO:0000134
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: enolase
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.11
is: SBO:0000176
fast: false
reversible: true

metaR CSm
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
kinetic law: MODEL1310110037#
type: Reaction
name: citrate synthase
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.1
is: SBO:0000176
reversible: false
product: MODEL1310110037#
modifier: MODEL1310110037#

metaR r0911
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
type: Reaction
reversible: true
product: MODEL1310110037#
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000

metaR GLCURtly
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
fast: false
name: glucuronate transport into lysososme
type: Reaction
is: SBO:0000185
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is described by: ECO:0000269
kinetic law: MODEL1310110037#

metaR r0990
product: MODEL1310110037#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true

metaR HDCEAtr
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
name: fatty acid transport via diffusion
fast: false

metaM 5fthf m
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: HMDB01562
name: 5-formyltetrahydrofolate(2-)
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57457
is: SBO:0000247

metaR GAPD
name: glyceraldehyde-3-phosphate dehydrogenase
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.12
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_88ea6c3f_3ce3_43bf_9766_a73013b44c9c
has only substance units: false
is: SBO:0000252
is: Q15181
initial amount: NaN
name: PPA1
is encoded by: hsa:5464
constant: false
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_de2f2319_e7fe_4664_b617_e7ad6f934e91
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI024818
name: _AI024818_1_c
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_6aefea5f_a108_4307_8761_85524609bf17
is encoded by: hsa:7296
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q16881
initial concentration: NaN
boundary condition: true
constant: false
name: TXNRD1

http://identifiers.org/biomodels.db/MODEL1310110037#_b2a194ad_d2b7_45dc_86e6_a5fb766e7cd8
name: ENTPD8
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:377841
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q5MY95

metaM CE2434 m
constant: false
is: CHEBI:57795
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA

metaM ha pre1 l
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
name: hyaluronan biosynthesis, precursor 1
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16126
type: Species
initial amount: NaN
has only substance units: false

metaM CE5118 m
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
initial concentration: 1.0
type: Species
is: HMDB00127
is: SBO:0000247
is: CHEBI:15748
has only substance units: false
boundary condition: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_196a8a5a_ccc2_4f21_a6a0_71082ee8faf4
boundary condition: true
initial concentration: NaN
name: PPA2
type: Species
has only substance units: false
is encoded by: hsa:27068
constant: false
is: SBO:0000252
initial amount: NaN

metaM dad 2 e
type: Species
is: SBO:0000247
constant: false
name: 2-deoxyadenosine
is: HMDB00101
initial amount: NaN
is: CHEBI:17256
boundary condition: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
has only substance units: false
initial concentration: 1.0

metaR r1434
fast: false
is: SBO:0000185
reversible: false
product: MODEL1310110037#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110037#

metaR r0055
reversible: true
reactant: MODEL1310110037#
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.4.2.8
is version of: http://identifiers.org/ec-code/2.4.2.7
is described by: ECO:0000000
modifier: MODEL1310110037#
is: SBO:0000176
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
type: Reaction
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR r2202
reactant: MODEL1310110037#
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_d1bab0ef_70ad_441a_9207_7ca9df01f9cc
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:51557
initial concentration: NaN
is: Q5TDP6
initial amount: NaN
has only substance units: false
type: Species
name: LGSN

metaR DCK1n
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true
name: Deoxycytidine kinase, nuclear (ATP)
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
kinetic law: MODEL1310110037#
is described by: ECO:0000269
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
type: Reaction

metaM prostgf2 c
is: SBO:0000247
is: CHEBI:57404
initial concentration: 1.0
name: prostaglandin F2alpha(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01139
type: Species

metaR HSD3A1r
reversible: true
reactant: MODEL1310110037#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110037#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110037#
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_273706d9_84ba_4f22_8428_b8a360309368
is: Q8IZH9
is encoded by: hsa:2643
initial amount: NaN
name: GCH1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR r0913
reversible: true
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000

metaR FTHFL
name: Formate-tetrahydrofolate ligase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_52f83b5d_e314_45eb_9ac8_2166c9bbf6b3
is: P05187
constant: false
is: SBO:0000252
initial amount: NaN
name: ALPP
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:250

metaR CHAT
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
modifier: MODEL1310110037#
is: SBO:0000176
name: Choline O-acetyltransferase
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.6
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
reversible: true
product: MODEL1310110037#

metaM gacpail hs r
type: Species
name: glucosaminyl-acylphosphatidylinositol
is: CHEBI:61548
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB01401
constant: false
is: C00092

metaR r0268
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000176
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.1.3.2

metaM datp c
has only substance units: false
type: Species
is: HMDB01532
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
is: C00131
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_16027a51_b393_432c_87aa_ad9334437ed1
is: SBO:0000252
name: DGKE
initial amount: NaN
constant: false
is encoded by: hsa:8526
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: A1L4Q0

http://identifiers.org/biomodels.db/MODEL1310110037#_53c568b5_7398_46eb_b556_247ff8d98f41
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:642502
constant: false
name: _642502_1_c
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_643db119_1cd1_4860_aa1b_6eb79967756b
constant: false
initial concentration: NaN
initial amount: NaN
name: SLC2A11
is: Q8WXF9
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:66035
has only substance units: false

metaM dutp c
is: CHEBI:17625
constant: false
initial amount: NaN
is: HMDB01191
initial concentration: 1.0
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
has only substance units: false
boundary condition: false
is: C00460
is: SBO:0000247
type: Species
name: dUTP

metaR TCYNTt
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#

metaR CHOLD2m
kinetic law: MODEL1310110037#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.99.1
is described by: ECO:0000269
product: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000176
name: choline dehydrogenase (FAD acceptor), mitochondrial
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_1a43b52d_1b18_47fe_87a4_466d3339ae64
name: SLC7A9
is: P82251
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:11136
type: Species
initial concentration: NaN

metaR NRPPHRt4 2 r
reactant: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
fast: false
name: Norepinephrine reversible transport in via sodium symport (1:2)
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185

metaR r0267
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.5.1.9
product: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
modifier: MODEL1310110037#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000

metaM dad 2 c
type: Species
is: SBO:0000247
constant: false
name: 2-deoxyadenosine
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
boundary condition: false
has only substance units: false
is: CHEBI:17256
is: HMDB00101
initial amount: NaN
initial concentration: 1.0

metaM pyr c
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
is: CHEBI:15361
initial concentration: 1.0
constant: false
is: HMDB00243
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1
has only substance units: false
is: SBO:0000247
is: C00022
type: Species
initial amount: NaN

metaR RE0926E
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
name: RE0926
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110037#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false

metaR TYRt
kinetic law: MODEL1310110037#
fast: false
product: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
is: SBO:0000185
reversible: true
name: L-tyrosine transport
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_8de1f8cb_887d_494c_b54c_ec7ea5a6b6df
is: A0PJJ9
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:2686
type: Species
initial concentration: NaN
boundary condition: true
name: GGT7

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_6732c941_f63b_4b68_8fee_497d65b5cb42
has only substance units: false
constant: false
is: Q13011
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: ECH1
is encoded by: hsa:1891

metaM prostgf2 e
is: CHEBI:57404
initial concentration: 1.0
name: prostaglandin F2alpha(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01139
is: SBO:0000247
has only substance units: false
type: Species

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_36966cb2_62c7_43c8_b728_19652be03ef6
name: SLC25A1
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: D9HTE9
is encoded by: hsa:6576
boundary condition: true
constant: false

metaM udp n
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00295
is: CHEBI:58223
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
name: UDP(3-)

metaR r0993
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
type: Reaction
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_03355345_f583_459b_a200_bd0720f8529a
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:622
boundary condition: true
name: BDH1

metaR r0915
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110037#

metaR RE1517M
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
fast: false
is described by: ECO:0000000
modifier: MODEL1310110037#
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
kinetic law: MODEL1310110037#

metaR r0377
reversible: false
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
reactant: MODEL1310110037#

metaR RE1530C
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
kinetic law: MODEL1310110037#
name: RE1530
reversible: true
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000176
product: MODEL1310110037#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_b0ed87d0_83ed_4ddc_bac2_6a388050c7e2
name: NME6
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10201
boundary condition: true
constant: false
is: O75414
is: SBO:0000252

metaR HGNTOR
is described by: ECO:0000269
fast: false
reversible: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.13.11.5
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
product: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
is: SBO:0000176

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR DM ethamp r
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR NDPK8n
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110037#
reversible: true
modifier: MODEL1310110037#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
product: MODEL1310110037#
type: Reaction

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_adb99a1c_b40b_43f8_ae42_601a7f3ff2aa
has only substance units: false
is: P00441
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:6647
name: SOD1
initial amount: NaN
boundary condition: true

metaR CYTK8n
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,dATP),nuclear
type: Reaction

metaR r0994
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: Facilitated diffusion
reactant: MODEL1310110037#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is: SBO:0000185

metaM nadh r
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: NADH(2-)
is: HMDB01487
has only substance units: false
is: CHEBI:57945
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3eb3bb1d_2848_4225_92fc_10bf40e74bd2
boundary condition: true
name: _NM_013421_1_m
constant: false
is encoded by: hsa:NM 013421
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR RAI1
is described by: ECO:0000000
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000176
name: retinal isomerase (11-cis)
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
product: MODEL1310110037#

metaM tdcoa m
is: HMDB01521
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: C02593
boundary condition: false
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
type: Species

metaM amp r
initial concentration: 1.0
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: AMP
type: Species
is: SBO:0000247
is: CHEBI:456215
is: C00020

metaR r1917
fast: false
is: SBO:0000185
reversible: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_bfe0f489_94f6_4247_a91a_fef325f5adba
is encoded by: hsa:3030
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: HADHA
boundary condition: true
is: SBO:0000252
is: E9KL44

metaR r1538
modifier: MODEL1310110037#
is described by: ECO:0000000
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
product: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110037#_582e9017_0e04_46f0_af88_a70efa95cae1
has only substance units: false
is encoded by: hsa:57282
is: B7Z1R0
name: SLC4A10
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_606eac5b_dddc_4d19_a168_8e795c4a059a
is encoded by: hsa:83549
name: UCK1
has only substance units: false
is: SBO:0000252
constant: false
is: Q5JT09
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaM chol m
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
is: HMDB00097
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: choline
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaR r2366
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110037#

metaR BILGLCURtr
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is described by: ECO:0000000
reversible: true
fast: false
name: glucuronidated compound transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110037#

metaR FRUt1r
name: D-fructose transport in via uniport
modifier: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
product: MODEL1310110037#
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (29988.1) or (6514.1) or (155184.1) or (6518.1) or (66035.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10821868,PMID:10860996,PMID:11583593,PMID:11780753,PMID:11882499,PMID:12135767,PMID:12750891,PMID:15033637,PMID:1634504,PMID:1695905,PMID:1701966,PMID:2182619,PMID:3399500,PMID:8419132,PMID:9770484 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110037#_9fe61693_e911_4232_b836_56cb2fbe73d3
boundary condition: true
type: Species
is: Q13057
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:80347
has only substance units: false
name: COASY

metaR PIPLC
reversible: false
type: Reaction
name: phosphatidylinositol phospholipase C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reactant: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_1681023f_02ee_44d8_93f7_583e591baf66
is: SBO:0000252
is encoded by: hsa:55907
name: CMAS
boundary condition: true
is: Q8NFW8
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_4ef2c388_6d7e_4309_a4a8_26a1e1ca43e1
has only substance units: false
boundary condition: true
name: ACADVL
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:37
is: P49748
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_63e7c0b9_3038_4bde_ab79_f7dd2ca4c7d4
initial amount: NaN
constant: false
name: _AI653169_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI653169
type: Species
initial concentration: NaN

metaM HC01118 r
type: Species
initial amount: NaN
is: SBO:0000247
name: presqualene diphosphate(3-)
constant: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: CHEBI:57310
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_81888676_ae60_43b9_8623_55d198de5523
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR r0796
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
reactant: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_7f0efb8c_f0b5_42b3_997d_9641e3f70fff
is encoded by: hsa:3073
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P06865
name: HEXA
type: Species

metaM chol n
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
constant: false
initial concentration: 1.0
is: SBO:0000247
name: choline
boundary condition: false
is: HMDB00097

metaR PHCHGSm
fast: false
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reversible: true
reactant: MODEL1310110037#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_d3e1bc49_08d0_41b5_bce0_273473fea4ae
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: SLC28A1
initial amount: NaN
is encoded by: hsa:9154
is: Q96PL7
is: SBO:0000252

metaR r0287
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110037#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaM 3hmp m
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00023
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: CHEBI:11805
boundary condition: false
type: Species
has only substance units: false

metaR r2365
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaR DOLPMT3 Uer
type: Reaction
reversible: false
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
fast: false
is described by: ECO:0000000
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.4.1.260

metaR RDH2a
name: retinol dehydrogenase (9-cis,NADPH)
modifier: MODEL1310110037#
fast: false
is described by: ECO:0000269
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.300
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.105

metaM ha deg1 l
name: hyaluronan degradation product 1
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C22H33N2O16 CHARGE: -1
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:16336
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_b0cbb653_f21f_4db8_83fb_26cf9ede95d4
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: Q8NBL9
boundary condition: true
is encoded by: hsa:94005
is: SBO:0000252
initial amount: NaN
name: PIGS

metaR LTC4CP
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reactant: MODEL1310110037#
name: Leukotriene C4 carboxypeptidase
fast: false
product: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
reversible: true

metaM Rtotal e
boundary condition: false
is: CHEBI:3554
constant: false
initial amount: NaN
name: R total
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: C00255
notes: FORMULA: CO2FULLR CHARGE: -1
is: HMDB00244

metaM sphs1p e
boundary condition: false
name: sphingosine 1-phosphate(1-)
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
is: HMDB00277

metaM pail4p hs n
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
has only substance units: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

metaM HC01399 m
initial concentration: 1.0
name: (S)-3-Hydroxytetradecanoyl-CoA
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: CHEBI:27466

http://identifiers.org/biomodels.db/MODEL1310110037#_cb4ee14a_90b2_4f08_92f1_f3bce24af825
initial concentration: NaN
is encoded by: hsa:2348
boundary condition: true
name: FOLR1
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_c0950e86_25eb_4f89_818c_36a66758b9bb
constant: false
type: Species
is: Q92819
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3037
initial concentration: NaN
has only substance units: false
name: HAS2
initial amount: NaN

metaM glyc3p x
type: Species
name: Glycerol 3-phosphate
is: C00093
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57597
constant: false
is: HMDB00126

http://identifiers.org/biomodels.db/MODEL1310110037#_d3959d75_9c21_4503_9946_4cd16d70f44f
name: ALDH1B1
is: SBO:0000252
is encoded by: hsa:219
boundary condition: true
initial concentration: NaN
is: P30837
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM 2mbcoa m
name: 2-methylbutanoyl-CoA(4-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57336
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: HMDB01041

http://identifiers.org/biomodels.db/MODEL1310110037#_cb43ed12_308f_403f_87da_9a28b7086a20
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _AL048840_1_c
has only substance units: false
type: Species
constant: false
is encoded by: hsa:AL048840
is: SBO:0000252

metaR r0797
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
product: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
name: glycine N-choloyltransferase EC:2.3.1.65
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_a6eb60aa_175e_485c_bd0f_cc71820d28bb
has only substance units: false
name: _H17063_1_c
is: SBO:0000252
is encoded by: hsa:H17063
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaR r2364
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_f9d46dc9_0b32_4379_b67f_29aed5b7ed70
is: Q96PE7
name: MCEE
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84693
type: Species
initial amount: NaN
constant: false

metaR r0917
type: Reaction
product: MODEL1310110037#
fast: false
reversible: true
kinetic law: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR r1762
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
type: Reaction
fast: false

metaM mlthf m
is: CHEBI:15636
is: HMDB01533
initial concentration: 1.0
initial amount: NaN
is: C00143
type: Species
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
name: 5,10-Methylenetetrahydrofolate

metaM gly c
type: Species
is: CHEBI:3339
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
name: Glycine
has only substance units: false
is: SBO:0000247

metaM HC01842 c
constant: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
boundary condition: false
initial concentration: 1.0
is: CHEBI:31997
has only substance units: false
type: Species
is: SBO:0000247
name: Phosphodimethylethanolamine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_78d17c25_04fc_4583_8868_a52ad443ee9c
initial concentration: NaN
constant: false
is encoded by: hsa:51292
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: GMPR2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_97ac7983_9b14_46b4_90ad_ad57a5218004
type: Species
initial concentration: NaN
is encoded by: hsa:728441
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GGT2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_c4b0020b_cc55_4a68_85a1_7d33b3732dc3
type: Species
constant: false
initial concentration: NaN
name: NAE1
initial amount: NaN
boundary condition: true
is encoded by: hsa:8883
is: SBO:0000252
is: A8MU28
has only substance units: false

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR HPYRRy
is: SBO:0000176
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.79
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
reversible: false
fast: false
reactant: MODEL1310110037#
name: Hydroxypyruvate reductase (NADPH)
product: MODEL1310110037#

metaR RE2814R
reactant: MODEL1310110037#
type: Reaction
name: RE2814
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false

metaM sphs1p c
initial concentration: 1.0
is: HMDB00277
is: CHEBI:60119
boundary condition: false
name: sphingosine 1-phosphate(1-)
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: SBO:0000247
constant: false

metaR r2363
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_278fe533_19fb_44ca_b090_a828f3e61fb7
boundary condition: true
constant: false
is: Q9NRX3
name: NDUFA4L2
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:56901
has only substance units: false
is: SBO:0000252

metaR DUTPDPn
is version of: http://identifiers.org/ec-code/3.6.1.23
product: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
name: dUTP diphosphatase, nuclear
reactant: MODEL1310110037#
is: SBO:0000176
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
type: Reaction
is described by: ECO:0000269

metaM Rtotal c
has only substance units: false
is: CHEBI:16189
is: HMDB01448
type: Species
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: R total
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_94dd1b26_08f4_43e6_ac5d_da801527db29
is encoded by: hsa:83884
boundary condition: true
is: Q9BXI2
is: SBO:0000252
constant: false
name: SLC25A2
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaM acnam c
is: SBO:0000247
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
is: HMDB00230
name: N-acetylneuraminate
initial concentration: 1.0
is: CHEBI:35418
has only substance units: false
boundary condition: false
constant: false

metaR L LACDcm
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
is described by: ECO:0000000
product: MODEL1310110037#
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
is: SBO:0000185
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
reversible: false
reactant: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_1a1bed8a_14cf_4d96_a602_7e2bd32b48cb
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51292
name: GMPR2
has only substance units: false
is: Q9P2T1
type: Species

metaR ABTti
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: false
name: L-arabinitol transport via passive diffusion
fast: false

metaR C204CRNt
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: arachidonic acid transport into the mitochondria
fast: false
type: Reaction
reversible: false
is: SBO:0000185

metaM cit c
initial concentration: 1.0
name: Citrate
is: C00158
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
is: CHEBI:16947
type: Species
is: HMDB00094
constant: false
has only substance units: false
is: SBO:0000247

metaR ADK1
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
modifier: MODEL1310110037#
is described by: ECO:0000269
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false
name: adenylate kinase
reactant: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR RE1523M
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
product: MODEL1310110037#
is: SBO:0000176
fast: false
modifier: MODEL1310110037#
name: RE1523
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110037#_85b3a3d2_48e0_43ea_8de6_23c56914a9b7
initial amount: NaN
has part: P22392
is encoded by: hsa:4831
constant: false
is encoded by: hsa:4830
boundary condition: true
is: SBO:0000297
type: Species
initial concentration: NaN
has only substance units: false
has part: P15531
name: NME1:NME2

metaR r2420
product: MODEL1310110037#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110037#

metaR ME2m
modifier: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
name: malic enzyme (NADP), mitochondrial
fast: false
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.38
is version of: http://identifiers.org/ec-code/1.1.1.40
reactant: MODEL1310110037#
is: SBO:0000176

metaR RE2814M
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
name: RE2814
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110037#
is: SBO:0000176

metaR r0393
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
fast: false
is: SBO:0000176
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_fdbd61c4_4a79_45ed_a9cb_2734931bfac0
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:29922
boundary condition: true
constant: false
initial amount: NaN
name: NME7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_5868e89a_0464_4f79_af5c_b509846bc8a0
constant: false
name: _AI291895_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AI291895

metaR MMEm
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.99.1
name: methylmalonyl-CoA epimerase/racemase
is: SBO:0000176
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
fast: false
product: MODEL1310110037#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR H2Otly
fast: false
name: H2O transport, lysosomal
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185

metaR r1914
reversible: false
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110037#

metaM uri c
is: C00299
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: Uridine
has only substance units: false
is: SBO:0000247
is: CHEBI:16704
is: HMDB00296
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299

http://identifiers.org/biomodels.db/MODEL1310110037#_ff730bb1_f52d_448a_b69a_6c2ba891eab0
has only substance units: false
initial amount: NaN
type: Species
name: INPP5J
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27124
is: SBO:0000252

metaR MI14P4P
is: SBO:0000176
fast: false
name: inositol-1,4-bisphosphate 4-phosphatase
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction

metaR r0170
product: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_7a919472_d8ed_4c30_951d_3c6065496274
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:F23536
name: _F23536_1_m
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM ocdca e
name: octadecanoate (n-C18:0)
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
constant: false
is: HMDB00827
is: CHEBI:25629
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C01530

metaM ala L m
type: Species
constant: false
is: HMDB00161
name: L-alanine
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16977
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_b54aec0d_d6b7_4b00_81c3_fe4b2ea353c2
type: Species
name: CERK
is encoded by: hsa:64781
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r0394
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000

metaR r2369
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000

metaR PYNP2r
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: pyrimidine-nucleoside phosphorylase (uracil)
is version of: http://identifiers.org/ec-code/2.4.2.3
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_16c2127d_d923_4c4d_956d_ec25cce6eb3b
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q548A7
constant: false
has only substance units: false
name: SLC26A6
is encoded by: hsa:65010
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_12bed8ab_8bb9_4520_8d16_4271b34f000c
name: AK3
boundary condition: true
constant: false
is: E7ET30
is encoded by: hsa:50808
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaM tyr L e
boundary condition: false
is: HMDB00158
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN
is: CHEBI:17895
has only substance units: false
type: Species
name: L-tyrosine
initial concentration: 1.0
is: SBO:0000247

metaM betald c
type: Species
is: HMDB01252
name: betaine aldehyde
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710
boundary condition: false
has only substance units: false

metaM amp x
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
initial concentration: 1.0
name: AMP
boundary condition: false
is: C00020
has only substance units: false
type: Species
is: CHEBI:456215
is: SBO:0000247
is: HMDB00045

http://identifiers.org/biomodels.db/MODEL1310110037#_83172f2a_c33d_483f_8fc1_38f40b3077e4
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110037#_3f81ff84_2b85_4845_87d2_fe8b1537dcf8
type: Species
is: A8K003
constant: false
is encoded by: hsa:5372
has only substance units: false
name: PMM1
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_038b060b_db26_47bc_9af6_44482f7e05e0
name: _206_1_c
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:206
type: Species
has only substance units: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_fb89d508_bcce_4ac6_ab54_cdbbef0ecaf2
is: SBO:0000252
initial amount: NaN
name: TXNRD1
has only substance units: false
type: Species
constant: false
is encoded by: hsa:7296
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_01069295_decb_4b96_b6ca_2fc3d05c13eb
has only substance units: false
name: HPD
initial concentration: NaN
initial amount: NaN
is: B3KQ63
type: Species
is encoded by: hsa:3242
boundary condition: true
constant: false
is: SBO:0000252

metaR r2368
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
type: Reaction

metaR r0391
product: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reversible: true
fast: false
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
type: Reaction
is: SBO:0000176
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:

metaR 10FTHF7GLUtl
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
product: MODEL1310110037#
name: 7-glutamyl-10FTHF transport, lysosomal
type: Reaction
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000000

metaM dpcoa e
is: HMDB01373
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
boundary condition: false
initial concentration: 1.0
is: CHEBI:57328
constant: false
name: Dephospho-CoA
initial amount: NaN
is: SBO:0000247
is: C00882
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_63bcdcec_54a6_4eb8_9d95_83fc61fff7df
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: CA12
type: Species
initial amount: NaN
is encoded by: hsa:771
constant: false

metaR r1641
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ADK3
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
name: adentylate kinase (GTP)
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction

metaR ECOAH12m
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
reactant: MODEL1310110037#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110037#
type: Reaction
is described by: ECO:0000304
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM focytC m
constant: false
initial concentration: 1.0
is: CHEBI:16928
type: Species
name: Ferrocytochrome C
boundary condition: false
is: SBO:0000247
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_ddd84094_adde_417c_a829_34961c2dc69a
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:224
boundary condition: true
initial concentration: NaN
name: ALDH3A2
is: P51648
constant: false
has only substance units: false

metaM HC01405 m
constant: false
has only substance units: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
name: (S)-Hydroxyoctanoyl-CoA
type: Species
initial amount: NaN
is: CHEBI:28632
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM Rtotal2coa c
boundary condition: false
is: C00055
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
name: R total 2 coenzyme A
is: HMDB00095
initial concentration: 1.0
type: Species
is: CHEBI:60377

metaM dpcoa c
type: Species
initial concentration: 1.0
is: C00882
name: Dephospho-CoA
initial amount: NaN
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
is: SBO:0000247
boundary condition: false
is: HMDB01373
has only substance units: false

metaR r0527
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_53797d9b_8e8b_43ad_8829_add9982d4965
boundary condition: true
type: Species
is: Q53Y41
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:1644
initial amount: NaN
initial concentration: NaN
name: DDC

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM uri e
boundary condition: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
is: HMDB00296
initial amount: NaN
constant: false
is: C00299
name: Uridine
has only substance units: false
initial concentration: 1.0
is: CHEBI:16704
type: Species

metaR r0392
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_4aa33724_2968_4ebb_bab7_b6e3060bca6c
boundary condition: true
name: PANK2
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:80025
is: Q6P1K9
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR LTD4DP
type: Reaction
kinetic law: MODEL1310110037#
name: Leukotriene D4 dipeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110037#

metaM ocdca c
is: SBO:0000247
has only substance units: false
name: stearate
boundary condition: false
initial amount: NaN
is: CHEBI:25629
constant: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
is: HMDB00827
type: Species

metaR r2367
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000185
type: Reaction
reversible: true

metaR r1640
is described by: ECO:0000000
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_37b1a55a_0b4e_4def_9630_328cc2aea576
is encoded by: hsa:2023
is: SBO:0000252
type: Species
initial concentration: NaN
name: ENO1
has only substance units: false
boundary condition: true
constant: false
is: E2DRY6
initial amount: NaN

metaR 10FTHF7GLUtm
reversible: false
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:mechanism is unknown IT
name: 7-glutamyl-10FTHF transport, mitochondrial
fast: false
is described by: ECO:0000000

metaR DCSPTN1CRNt
is described by: ECO:0000269
modifier: MODEL1310110037#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: transport into the mitochondria (carnitine)
reversible: false
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_c80ec867_e3b7_4cea_89bb_3468a3398ccb
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q6IA69
initial amount: NaN
is encoded by: hsa:55191
name: NADSYN1

http://identifiers.org/biomodels.db/MODEL1310110037#_4cc7348b_3678_4bf3_b258_eb58b1fdb9d9
has only substance units: false
constant: false
type: Species
is encoded by: hsa:8733
initial concentration: NaN
boundary condition: true
name: GPAA1
is: SBO:0000252
is: O43292
initial amount: NaN

metaR r1643
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110037#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110037#

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR CYOR u10m
is: SBO:0000185
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
reversible: false
type: Reaction
reactant: MODEL1310110037#
name: ubiquinol-6 cytochrome c reductase, Complex III
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_70cb2741_b571_4630_b704_d8f6ade10c26
has only substance units: false
initial amount: NaN
type: Species
name: DPYSL2
is encoded by: hsa:1808
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: B4DR31
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_ed4719cc_8153_4ff9_915c_d491eb2bf986
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:1431
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: CS

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_75f2825c_b28b_43d5_8fa7_324799f9b771
constant: false
is encoded by: hsa:125206
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC5A10
is: A0PJK1
boundary condition: true

metaM tyr L c
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: HMDB00158
initial concentration: 1.0
has only substance units: false
type: Species
name: L-tyrosine
is: CHEBI:17895

http://identifiers.org/biomodels.db/MODEL1310110037#_2db79b29_bbca_4890_a2b2_3dea3e3f36f2
has only substance units: false
name: _T83654_1_c
is encoded by: hsa:T83654
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true

metaR r2506
name: Utilized transport
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110037#
reversible: true

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_7958d144_241a_432e_9ddd_e7f6aff448ed
is encoded by: hsa:4953
has only substance units: false
name: ODC1
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P11926
initial concentration: NaN

metaR PPItx
is: SBO:0000185
product: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
name: Diphosphate transporter, peroxisome
reactant: MODEL1310110037#
type: Reaction

metaR r0390
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
fast: false
reversible: true
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is described by: ECO:0000000

metaR r1642
reversible: true
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_242f630c_d47a_4925_8f9c_9f77cf7fba4d
is: SBO:0000252
constant: false
is: Q9H845
boundary condition: true
initial amount: NaN
has only substance units: false
name: ACAD9
initial concentration: NaN
is encoded by: hsa:28976
type: Species

metaR FAOXC160
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
product: MODEL1310110037#
reversible: false
is: SBO:0000176
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR TRIODTHYt2
type: Reaction
is described by: ECO:0000269
fast: false
name: T3 transport via facilitated diffusion
is: SBO:0000185
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
kinetic law: MODEL1310110037#

metaM mal L m
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:15589
is: HMDB00156

metaM dolp U r
constant: false
type: Species
name: dolichyl phosphate(2-)
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
is: CHEBI:57683
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_46cbf17b_b266_4c04_afb3_0c8522f50ef5
initial concentration: NaN
name: SLC34A1
is: Q7Z725
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6569
constant: false
type: Species
initial amount: NaN

metaM 4abut c
type: Species
is: HMDB00112
has only substance units: false
initial amount: NaN
is: C00334
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:3628
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
name: 4-Aminobutanoate

metaR SPC HSt
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: sphingosylphosphorylcholine transport (diffusion)
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_8e242471_53a2_46ce_ba35_e170161f15ba
is encoded by: hsa:4698
name: NDUFA5
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q16718
type: Species
has only substance units: false
constant: false

metaR r0634
product: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
is: SBO:0000176
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_e885a316_90ba_463d_b521_0583b079c1d9
constant: false
boundary condition: true
initial concentration: NaN
is: Q6FGA0
type: Species
has only substance units: false
name: COX7A2L
is: SBO:0000252
is encoded by: hsa:9167
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_efcda4ee_41ed_4529_8c8e_41e4ac53de48
boundary condition: true
is encoded by: hsa:6342
constant: false
name: SCP2
type: Species
is: C9JC79
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR SERt4
kinetic law: MODEL1310110037#
name: L-serine via sodium symport
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
reversible: false
modifier: MODEL1310110037#
fast: false
is described by: ECO:0000269

metaR r1645
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110037#_9f3a2f27_3a11_4d0a_bb46_536ac88fc6f7
initial concentration: NaN
constant: false
type: Species
name: HSD3B7
boundary condition: true
is: Q9H2F3
initial amount: NaN
is encoded by: hsa:80270
has only substance units: false
is: SBO:0000252

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_0d7bb9b2_6402_4e8c_8b90_309c4384ed44
type: Species
is encoded by: hsa:5281
has part: Q8TEQ8
initial amount: NaN
has part: Q07326
name: PIGF:PIGO
boundary condition: true
constant: false
is encoded by: hsa:84720
is: SBO:0000297
has only substance units: false
initial concentration: NaN

metaM idp n
is: HMDB03335
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:58280
name: IDP(3-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_1d999ff8_a244_4e64_b5ce_3d4bb4f1511b
name: ENTPD1
initial concentration: NaN
has only substance units: false
is: Q86VV3
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:953
type: Species

metaR RETNt
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: retinoic acid transport
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
type: Reaction
is: SBO:0000185
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_e18915cb_8871_4254_be8c_6e4b757d9153
initial concentration: NaN
name: CLYBL
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q8N0X4
type: Species
boundary condition: true
is encoded by: hsa:171425
constant: false

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
name: RE3272
product: MODEL1310110037#
is: SBO:0000176
type: Reaction
reversible: true
fast: false

metaM 5aop m
name: 5-Amino-4-oxopentanoate
is: C00430
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
boundary condition: false
is: CHEBI:17549
has only substance units: false
is: HMDB01149
initial concentration: 1.0
type: Species
constant: false

metaR r2508
is described by: ECO:0000000
name: Utilized transport
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaM CE4792 m
is: CHEBI:15748
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
is: HMDB00127
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 3-oxo-cis-8-tetradecenoyl-CoA
has only substance units: false

metaR r1644
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
modifier: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaR FACOAL224
reversible: true
name: fatty-acid--CoA ligase
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_4ad754b7_6347_4eca_8dd3_24a4d1e86be0
name: PRDX3
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10935
type: Species
constant: false
is: E9PH29
has only substance units: false
initial concentration: NaN

metaR r0281
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000
modifier: MODEL1310110037#
fast: false
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaM sgalside hs c
constant: false
name: sulfatide galactocerebroside
type: Species
has only substance units: false
is: CHEBI:16523
is: HMDB03406
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial amount: NaN

metaR r0410
is described by: ECO:0000000
type: Reaction
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110037#
is: SBO:0000176
fast: false
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_a2c32149_18f3_40bf_a5b4_77dcf0f63e47
name: CMPK1
is: B2R6S5
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51727
boundary condition: true
has only substance units: false

metaM gdp c
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01201
name: GDP
constant: false
initial amount: NaN
is: CHEBI:58189
is: C00035
has only substance units: false
type: Species

metaR EX pectingchol LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-glycocholate complex
type: Reaction

metaM 4abut e
is: HMDB00112
initial amount: NaN
is: C00334
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
initial concentration: 1.0
type: Species
name: 4-Aminobutanoate
constant: false
is: SBO:0000247
is: CHEBI:3628
has only substance units: false

metaR GLYCt
product: MODEL1310110037#
is described by: ECO:0000000
fast: false
reversible: true
name: glycerol transport via channel
kinetic law: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
type: Reaction

metaR r2507
is described by: ECO:0000000
name: Utilized transport
reactant: MODEL1310110037#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaR ALADGLNexR
reactant: MODEL1310110037#
is described by: ECO:0000304
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
fast: false
name: L-alanine/glutamine reversible exchange
modifier: MODEL1310110037#

metaM datp n
has only substance units: false
name: dATP
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
initial amount: NaN
is: CHEBI:61404
initial concentration: 1.0
type: Species
boundary condition: false
is: C00131

metaM amp m
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
name: AMP(2-)
type: Species
is: CHEBI:456215
boundary condition: false
is: HMDB00045
initial amount: NaN
constant: false
is: SBO:0000247

metaR 3HCO3 NAt
name: 3HCO3_NAt
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
reversible: true
is: SBO:0000185

metaR MTHFD2
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
reactant: MODEL1310110037#
is described by: ECO:0000134
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NAD)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_ae0c2d70_ea27_414c_83a6_0123cffa0a60
is encoded by: hsa:3157
name: HMGCS1
is: Q01581
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r1051
name: Vesicular transport
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false

metaR r2362
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110037#

metaM gly e
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00123
initial amount: NaN
is: C00037
boundary condition: false
is: SBO:0000247
is: CHEBI:3339
name: Glycine

http://identifiers.org/biomodels.db/MODEL1310110037#_24d16d1f_4586_4afd_bc94_2536010500d0
is encoded by: hsa:2222
is: SBO:0000252
boundary condition: true
name: FDFT1
is: P37268
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_19291df6_313b_45bf_8d2a_b02c782715b6
is: SBO:0000252
has only substance units: false
constant: false
name: _AA278423_1_m
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:AA278423

http://identifiers.org/biomodels.db/MODEL1310110037#_40880396_95b9_4251_b628_2bbf9b9c883c
is: P00568
is encoded by: hsa:203
is: SBO:0000252
name: AK1
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaR r0853
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
reversible: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
name: Facilitated diffusion
is: SBO:0000185

metaM retfa c
initial concentration: 1.0
name: fatty acid retinol
type: Species
boundary condition: false
is: HMDB00305
has only substance units: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
is: CHEBI:50211
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_65e25eb2_bfb8_447a_a8db_da5522f63d73
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:23556
initial concentration: NaN
name: PIGN

metaR r1647
is: SBO:0000185
type: Reaction
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0791
reactant: MODEL1310110037#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110037#
fast: false
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r0639
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_762eab79_5669_48ba_b5a7_3b8291ef5d07
boundary condition: true
is: O00624
name: SLC17A2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10246
has only substance units: false
type: Species
constant: false

metaR TYRTA
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110037#
name: tyrosine transaminase
reversible: true
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaR r2361
product: MODEL1310110037#
fast: false
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM betald m
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01252
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
name: betaine aldehyde
initial concentration: 1.0
is: CHEBI:15710

metaR r0178
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:

metaR r2501
fast: false
reactant: MODEL1310110037#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction

metaR MCLOR
name: 3-Mercaptolactate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000269
is: SBO:0000176
reversible: true
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:

metaM lnlncg e
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial amount: NaN
is: CHEBI:32391
is: HMDB03073
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: gamma-linolenate
is: SBO:0000247

metaR r1646
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110037#
fast: false

metaM thp2c x
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
name: 1-piperideine-6-carboxylate
is: CHEBI:16987
constant: false
is: HMDB12130
is: SBO:0000247
has only substance units: false

metaM 2pg c
is: CHEBI:58289
initial concentration: 1.0
is: C00631
has only substance units: false
constant: false
is: HMDB03391
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: 1/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1/f/h5,7-8H HEPATONET_1.0_ABBREVIATION: HC00463 EHMN_ABBREVIATION: C00631
is: SBO:0000247
name: D-Glycerate 2-phosphate
boundary condition: false
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3904

http://identifiers.org/biomodels.db/MODEL1310110037#_afd51dd9_e6a6_43df_a312_47f9cb36eafc
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:212
is: Q5JZF5
initial amount: NaN
name: ALAS2

http://identifiers.org/biomodels.db/MODEL1310110037#_50c4f67b_fae8_4e09_a264_de0cdeee3f77
is: Q9Y2B2
name: PIGL
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9487

http://identifiers.org/biomodels.db/MODEL1310110037#_ff5c2799_7449_46eb_ad29_fada98198de0
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: HADHB
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: P55084
is encoded by: hsa:3032

http://identifiers.org/biomodels.db/MODEL1310110037#_a68eac4a_16c2_409a_ba46_0ea22974a713
name: CMPK1
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:51727
boundary condition: true
initial concentration: NaN
is: B2R6S5
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_a1c1a6c1_affb_4ad7_9f7f_0da14ceac1cd
name: NDUFA11
is encoded by: hsa:126328
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: C9JT23

metaR r0638
is version of: http://identifiers.org/ec-code/2.8.1.2
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction

metaM dpcoa m
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01373
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57328
name: 3'-dephospho-CoA(2-)

metaR r2360
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110037#
is: SBO:0000185
fast: false
product: MODEL1310110037#

metaR ILETAm
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is: SBO:0000176
reversible: true
name: isoleucine transaminase, mitochondrial
fast: false
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

metaR r0179
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
modifier: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reversible: true
product: MODEL1310110037#

metaR PRISTCOAtcx
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR CHSTEROLt2
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
name: cholesterol intracellular transport
is: SBO:0000185
type: Reaction
product: MODEL1310110037#

metaR P450SCC1m
is: SBO:0000176
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
is described by: ECO:0000134
name: cholesterol monooxygenase
reversible: true
reactant: MODEL1310110037#
type: Reaction

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_d8f8009b_c939_47d8_a1fc_fcb056d4cdeb
boundary condition: true
name: _AA664770_1_m
is: SBO:0000252
is encoded by: hsa:AA664770
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaM retfa e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
type: Species
is: CHEBI:15963
is: SBO:0000247
name: fatty acid retinol
boundary condition: false
constant: false
is: HMDB00508

http://identifiers.org/biomodels.db/MODEL1310110037#_004914d0_de3f_4e62_adcb_ba2c295b1af4
boundary condition: true
name: ACOT7
is encoded by: hsa:11332
is: O00154
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

metaR r1649
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
is: SBO:0000185
type: Reaction
product: MODEL1310110037#

metaR BTNt2
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
modifier: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
is described by: ECO:0000269
fast: false
name: Biotin reversible transport via proton symport

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_9ca0b2b4_5476_4d59_953e_94c89c128d39
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:124
name: ADH1A:ADH1B
has part: P07327
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_6c443291_ef6f_4f1e_8531_51cac7fb42cf
is encoded by: hsa:29968
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: PSAT1
is: SBO:0000252
constant: false
initial amount: NaN

metaM nadph c
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00221
has only substance units: false
type: Species
is: C00005
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
is: CHEBI:57783

http://identifiers.org/biomodels.db/MODEL1310110037#_f597fce2_a21e_41a1_85dc_af238a7448e3
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q96G03
is encoded by: hsa:55276
is: SBO:0000252
type: Species
name: PGM2

metaM sgalside hs g
is: CHEBI:58343
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
has only substance units: false
name: sulfatide galactocerebroside
boundary condition: false
initial amount: NaN
is: HMDB00061

metaM lnlncg c
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB03073
initial concentration: 1.0
is: CHEBI:32391
type: Species
name: gamma-linolenate
boundary condition: false
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-

metaR CHSTEROLt1
type: Reaction
fast: false
reactant: MODEL1310110037#
name: cholesterol intracellular transport
is: SBO:0000185
reversible: true
product: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?

metaM CE2839 e
is: http://identifiers.org/pubchem.compound/5041
type: Species
initial concentration: 1.0
has only substance units: false
name: maltodecaose
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: SBO:0000247
is: C01936
constant: false
boundary condition: false
initial amount: NaN

metaR DITPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
type: Reaction
product: MODEL1310110037#
fast: false
name: dITP nuclear transport
reactant: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110037#

metaR NMNS
name: NMN synthetase
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:19513556 NOTES:
fast: false
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM pail4p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
is: CHEBI:58178
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaR RE3346C
name: RE3346
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110037#
fast: false
reversible: true
reactant: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:

metaR TSTSTERONEtr
is: SBO:0000185
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110037#
name: testosterone intracellular transport
kinetic law: MODEL1310110037#

metaR r1648
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
is described by: ECO:0000000

metaR GAMt1r
product: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
reactant: MODEL1310110037#
name: glucosamine transport (uniport)
reversible: true
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_18e4b1fe_d2cd_4e55_adf5_5a1a5bf9d66b
is: P49448
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: GLUD2
initial amount: NaN
is encoded by: hsa:2747
has only substance units: false
type: Species

metaM HC02206 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
boundary condition: false
name: prostaglandin C1(1-)
is: CHEBI:57399
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_236c28d2_7b42_42f3_904e_bd0718d3a171
is encoded by: hsa:23236
is: Q9NQ66
initial concentration: NaN
type: Species
name: PLCB1
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM 1pyr5c m
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01301
initial concentration: 1.0
has only substance units: false
is: CHEBI:15893
is: C03912
is: SBO:0000247
name: 1-Pyrroline-5-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110037#_0c4e166a_8733_4054_86b4_3ccf789eb342
boundary condition: true
is: Q8NFF2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:123041
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC24A4

metaR ADAe
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Adenosine deaminase, extracellular
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#

metaM pser L c
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: CHEBI:15811
name: O-Phospho-L-serine
type: Species
is: HMDB01721

http://identifiers.org/biomodels.db/MODEL1310110037#_45f33cc3_9477_4d65_b730_951c90f1f62c
is encoded by: hsa:6518
has only substance units: false
name: SLC2A5
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: P22732
initial concentration: NaN
constant: false

metaR XYLTD Dr
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
kinetic law: MODEL1310110037#
name: xylitol dehydrogenase (D-xyulose-forming)
reactant: MODEL1310110037#

metaM prostge2 e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
boundary condition: false
type: Species
has only substance units: false
is: HMDB01220
name: prostaglandin E2(1-)
is: SBO:0000247
is: CHEBI:606564
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_b30fc30e_3980_4cdf_9e30_0182159e109f
boundary condition: true
is encoded by: hsa:51251
initial amount: NaN
name: NT5C3
is: Q9H0P0
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_ccc871c3_0abb_4b1a_ac0e_33083440f89f
is: SBO:0000252
has only substance units: false
constant: false
is: P49753
type: Species
is encoded by: hsa:10965
boundary condition: true
name: ACOT2
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_a66a83e3_d7b5_45ac_a4ab_92f3085aade3
is: SBO:0000252
constant: false
type: Species
name: PAPSS1
has only substance units: false
is encoded by: hsa:9061
initial amount: NaN
initial concentration: NaN
is: O43252
boundary condition: true

metaR 10FTHFtl
product: MODEL1310110037#
is: SBO:0000185
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD, IT
kinetic law: MODEL1310110037#
name: 10-Formyltetrahydrofolate lysosomal transport via diffusion
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_d4b26134_78b6_4a0a_af5d_886562579823
is: Q9NPB1
initial amount: NaN
name: NT5M
boundary condition: true
is encoded by: hsa:56953
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_a750d2ae_6b5d_4e44_90d4_c198e8348e69
constant: false
initial concentration: NaN
is: SBO:0000252
name: HPGDS
is: O60760
has only substance units: false
initial amount: NaN
is encoded by: hsa:27306
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_6c2bbd6d_53d2_451d_bfe3_6347a988906d
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:10637
is: O75610
name: LEFTY1
has only substance units: false

metaM mal L c
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
name: (S)-malate(2-)
is: HMDB00156
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaM dcmp n
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01202
type: Species
is: CHEBI:57566
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
name: dCMP(2-)
initial amount: NaN

metaR DHPR2
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
is described by: ECO:0000304
reversible: false
name: 6,7-dihydropteridine reduction
kinetic law: MODEL1310110037#

metaM accoa c
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01206
is: CHEBI:57288
boundary condition: false
is: C00024
has only substance units: false
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false

metaM HC00718 c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: N-methylethanolaminium phosphate(1-)
is: SBO:0000247
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: CHEBI:57781
boundary condition: false
type: Species

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_b4c654bf_c712_4a46_b5df_5c4182382b24
is: SBO:0000252
is: O75907
has only substance units: false
type: Species
initial concentration: NaN
name: DGAT1
is encoded by: hsa:8694
constant: false
initial amount: NaN
boundary condition: true

metaM prostge2 c
initial concentration: 1.0
is: HMDB01220
type: Species
is: CHEBI:606564
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
has only substance units: false

metaM dolp L r
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57683
name: dolichyl phosphate(2-)
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
is: SBO:0000247

metaM dgdp c
has only substance units: false
name: dGDP
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: C00361
initial concentration: 1.0
is: CHEBI:58595
constant: false
type: Species
is: HMDB00960
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_8c68a906_80e8_467a_87b8_627def75b814
has only substance units: false
is: SBO:0000252
is: P08195
boundary condition: true
constant: false
type: Species
is encoded by: hsa:6520
name: SLC3A2
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_f55e1cd7_bab5_4bc2_9931_def0f471720b
initial amount: NaN
is encoded by: hsa:10423
constant: false
boundary condition: true
has only substance units: false
is: O14735
initial concentration: NaN
name: CDIPT
is: SBO:0000252
type: Species

metaM cdpdag hs c
constant: false
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: CDP-diacylglycerol(2-)

metaR DCSPTN1CPT2
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110037#
is: SBO:0000176
reversible: false
type: Reaction

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR r0497
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
is: SBO:0000176
modifier: MODEL1310110037#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
kinetic law: MODEL1310110037#

metaR PROSTGF2t
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
is: SBO:0000185

metaM 3pg m
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: HMDB00807
type: Species
is: SBO:0000247
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: CHEBI:58272
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM h m
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
initial concentration: 1.0
is: CHEBI:24636
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
constant: false
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false

metaM mi1p D c
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB02985
name: 1D-myo-inositol 1-phosphate(2-)
is: CHEBI:58433
constant: false
is: SBO:0000247

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_65f0960f_6c6a_44fe_8de7_62c9fc732248
has only substance units: false
constant: false
is encoded by: hsa:4833
is: SBO:0000252
type: Species
initial concentration: NaN
name: NME4
initial amount: NaN
boundary condition: true
is: O00746

metaM 4abut m
is: HMDB00112
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: C00334
name: 4-Aminobutanoate
is: CHEBI:16865
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
has only substance units: false
is: SBO:0000247

metaM 3ump e
initial concentration: 1.0
is: CHEBI:60784
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: 3'-UMP(2-)
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 EHMN_ABBREVIATION: C01368

metaM CE0849 m
is: CHEBI:57795
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: cis,cis-palmito-7,10-dienoyl-CoA
type: Species

metaM mal L e
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:15589
initial concentration: 1.0
is: HMDB00156
type: Species
has only substance units: false
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110037#_28ca9cf5_2b01_47bb_a058_d8444f6a29af
initial concentration: NaN
is encoded by: hsa:57835
type: Species
is: Q9BY07
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC4A5

metaM andrstandn r
name: 5alpha-androstane-3,17-dione
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: CHEBI:15994
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00899

metaR NCAMUP
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
reversible: false
fast: false
kinetic law: MODEL1310110037#
name: Nicotinamide acid uptake
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000000

metaR r2090
type: Reaction
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR CITL
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
reversible: false
is: SBO:0000176
reactant: MODEL1310110037#
modifier: MODEL1310110037#
name: Citrate lyase
is described by: ECO:0000000
type: Reaction

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaM cit m
name: Citrate
is: CHEBI:16947
is: C00158
type: Species
initial amount: NaN
is: HMDB00094
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_2e7c2422_44d4_4be2_8e20_a91e9b364372
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: _HG2846_HT2983_1_m
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM 4aphdob c
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: HMDB00978
constant: false
initial amount: NaN
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:58147
has only substance units: false

metaM amp c
is: SBO:0000247
has only substance units: false
name: AMP
is: CHEBI:3322
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: HMDB00045
constant: false
is: C00020
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

metaM retinal cis 13 r
has only substance units: false
constant: false
is: CHEBI:45487
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: HMDB06220
name: 13-cis-retinal

metaR DCSPTN1CPT1
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110037#
reversible: false
is described by: ECO:0000269
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110037#
reactant: MODEL1310110037#
fast: false

metaM 4abut n
constant: false
is: HMDB00112
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00334
name: 4-Aminobutanoate
initial amount: NaN
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0

metaM CE2418 m
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
is: SBO:0000247
is: CHEBI:28387
is: HMDB11123
constant: false

metaM HC02023 r
initial concentration: 1.0
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: Cholesterol-ester-ol
initial amount: NaN
is: CHEBI:46898

metaM h n
is: CHEBI:24636
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
boundary condition: false

metaM glygn2 e
notes: FORMULA: C66H111O56X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02134
initial amount: NaN
initial concentration: 1.0
is: CHEBI:4167
is: HMDB00122
has only substance units: false
constant: false
type: Species
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})
boundary condition: false
is: SBO:0000247

metaR r1428
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000000
name: Free diffusion

metaR r2509
product: MODEL1310110037#
name: Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_15f5b291_eae0_4e2d_a9de_f01cd783450d
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51292
initial amount: NaN
type: Species
name: GMPR2
is: SBO:0000252
boundary condition: true
is: Q86T14

metaM gdp m
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
name: GDP
is: HMDB01201
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00035
initial amount: NaN
boundary condition: false
is: CHEBI:58189
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_a5d835bd_d195_4c77_8526_ad541550d768
is: Q5MY95
is encoded by: hsa:377841
initial amount: NaN
initial concentration: NaN
constant: false
name: ENTPD8
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR DURIK1
type: Reaction
is described by: ECO:0000254
fast: false
reactant: MODEL1310110037#
name: deoxyuridine kinase (ATP:Deoxyuridine)
modifier: MODEL1310110037#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.21
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_3a617cbd_4537_484d_9590_8c89dc963312
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: _AI373818_1_m
has only substance units: false
is encoded by: hsa:AI373818

metaR PSERT
product: MODEL1310110037#
name: phosphoserine transaminase
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.52
fast: false
is described by: ECO:0000269
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
kinetic law: MODEL1310110037#
type: Reaction

metaR r1981
kinetic law: MODEL1310110037#
type: Reaction
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110037#
reversible: false
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false

metaR CHLtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
kinetic law: MODEL1310110037#
fast: false
reversible: true
name: choline transport via diffusion (cytosol to mitochondria)
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR r0630
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110037#
is described by: ECO:0000000
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
product: MODEL1310110037#

metaM na1 c
boundary condition: false
is: C01330
name: Sodium
is: HMDB00588
notes: FORMULA: Na CHARGE: 1
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: CHEBI:4541
initial amount: NaN
is: SBO:0000247

metaR CYTK12
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110037#
name: cytidylate kinase (dCMP,dCTP)
fast: false
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR 5ADTSTSTERONESte
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
type: Reaction
name: sulfonated testosterone transport
fast: false
product: MODEL1310110037#
is described by: ECO:0000000

metaR RE3003M
reversible: true
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110037#
fast: false
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
name: RE3003

metaR r1429
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Free diffusion
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR CMPSASn
fast: false
modifier: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: CMP sialic acid synthase, nuclear
is version of: http://identifiers.org/ec-code/2.7.7.43
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000304
reversible: false
type: Reaction

metaM CE5236 c
type: Species
is: CHEBI:28002
is: HMDB03952
boundary condition: false
initial amount: NaN
name: O2'-4a-cyclic-tetrahydrobiopterin
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_6a3a8e02_3699_42dd_8465_ef9df66d1205
type: Species
initial amount: NaN
initial concentration: NaN
is: P47989
name: XDH
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:7498

metaM sgalside hs l
has only substance units: false
initial concentration: 1.0
is: HMDB00904
is: CHEBI:16349
boundary condition: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
name: sulfatide galactocerebroside

metaM gly m
has only substance units: false
type: Species
is: CHEBI:15428
name: Glycine
initial concentration: 1.0
is: HMDB00123
is: C00037
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_0ea3e0f2_986a_4043_8fb8_d3c44040735e
initial concentration: NaN
constant: false
is encoded by: hsa:126
is: P00326
initial amount: NaN
boundary condition: true
type: Species
name: ADH1C
is: SBO:0000252
has only substance units: false

metaM 1pipdn2c x
is: HMDB01084
is: CHEBI:16187
initial concentration: 1.0
name: 1-piperideine-2-carboxylate
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_81d9958a_4f5b_4026_8262_f1581a371386
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: PI4KB
initial amount: NaN
is encoded by: hsa:5298
has only substance units: false
is: Q9UBF8

http://identifiers.org/biomodels.db/MODEL1310110037#_61a2985d_6cc1_485a_94e4_9f470a2f75fc
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:54407
has only substance units: false
name: SLC38A2
is: Q96QD8
boundary condition: true

metaR CYTK11
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dGTP)
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110037#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_72773c13_fe29_4d57_ad5c_338c09a92837
is encoded by: hsa:27068
name: PPA2
initial concentration: NaN
has only substance units: false
is: Q9H2U2
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

metaR RE1531M
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
modifier: MODEL1310110037#
reversible: true
fast: false
is described by: ECO:0000000
name: RE1531
reactant: MODEL1310110037#

metaM amp e
initial concentration: 1.0
type: Species
is: CHEBI:456215
is: C00020
is: SBO:0000247
name: AMP
boundary condition: false
is: HMDB00045
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false

metaM h l
name: proton
boundary condition: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:24636

metaR RIBt
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: true
product: MODEL1310110037#
type: Reaction
name: ribose transport via diffusion
fast: false

metaR PTPAT
modifier: MODEL1310110037#
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110037#
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.7.3
type: Reaction
fast: false
reversible: true

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaM lnlncg l
initial amount: NaN
name: gamma-linolenate
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
boundary condition: false
is: CHEBI:32391
is: HMDB03073
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_fa10a892_1e16_4dac_b532_dac94e40d1c2
is: P23378
is encoded by: hsa:2731
name: GLDC
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_981d581e_5df4_48fb_9ff7_d67b5de1ee78
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:54963
has only substance units: false
name: UCKL1
boundary condition: true
constant: false
is: Q53HM1

metaM HC01609 e
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0
name: UroporphyrinogenI
is: SBO:0000247
is: CHEBI:28766

metaM zymst r
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: zymosterol
type: Species
is: CHEBI:18252
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: HMDB06271
constant: false

metaM r1p c
initial concentration: 1.0
has only substance units: false
name: alpha-D-Ribose 1-phosphate
constant: false
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial amount: NaN
boundary condition: false
is: CHEBI:57720
type: Species
is: HMDB01489
is: C00442

http://identifiers.org/biomodels.db/MODEL1310110037#_a56819a4_9579_4eba_924f_860d2faedaf4
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: Q6P9G0
name: CYB5D1
is encoded by: hsa:124637
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR CYTK14
type: Reaction
is described by: ECO:0000269
name: cytidylate kinase (dCMP,UTP)
fast: false
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR UMPK3n
is: SBO:0000176
product: MODEL1310110037#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (UTP),nuclear

metaM sucsal m
constant: false
is: HMDB01259
boundary condition: false
name: Succinic semialdehyde
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57706

http://identifiers.org/biomodels.db/MODEL1310110037#_dc2dcf5a_0087_4f3b_aa9e_2a820a2f973d
type: Species
is: SBO:0000252
constant: false
name: SLC27A1
initial amount: NaN
is encoded by: hsa:376497
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_b2444608_39ec_4cbf_83e0_5cc9567fc7c7
type: Species
name: _D87002_1_e
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:D87002

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaM gdp n
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
name: GDP(3-)
constant: false
initial amount: NaN
is: CHEBI:58189
has only substance units: false
is: HMDB01201
is: SBO:0000247
boundary condition: false
type: Species

metaR CYTDK2m
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
name: cytidine kinase (ATP), mitochondrial
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
kinetic law: MODEL1310110037#

metaR ACGAM6PSi
kinetic law: MODEL1310110037#
reversible: false
type: Reaction
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
name: N-acetylglucosamine-6-phosphate synthase
reactant: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.4
product: MODEL1310110037#

metaR 10FTHFtm
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
product: MODEL1310110037#
is: SBO:0000185
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000000

metaR r0633
is described by: ECO:0000000
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.7.3
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
fast: false
is: SBO:0000176
reversible: true

metaM CE5119 m
type: Species
is: HMDB00127
initial amount: NaN
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
has only substance units: false
boundary condition: false
name: trans-3-cis-8-tetradecadienoyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_9f1b4930_a527_4f6a_9a76_3c0543982718
type: Species
boundary condition: true
initial amount: NaN
is: O95427
constant: false
initial concentration: NaN
is: SBO:0000252
name: PIGN
has only substance units: false
is encoded by: hsa:23556

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_eb30e876_e0bc_40d5_a761_af320a820c37
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q96CD2
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: PPCDC
is encoded by: hsa:60490

metaR CYTK11n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110037#
is: SBO:0000176
name: cytidylate kinase (dCMP,dGTP),nuclear
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#

metaR CYTK13
fast: false
kinetic law: MODEL1310110037#
name: cytidylate kinase (dCMP,dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110037#
reversible: true

metaR DUDPtn
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dUDP nuclear transport
is described by: ECO:0000000
fast: false

metaR 3MOBt2im
type: Reaction
fast: false
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
is described by: ECO:0000000
reactant: MODEL1310110037#
reversible: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
kinetic law: MODEL1310110037#
is: SBO:0000185

metaR r2096
is: SBO:0000185
reactant: MODEL1310110037#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110037#

metaR UDPGLCAter
is described by: ECO:0000269
reactant: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
reversible: true
product: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport

metaR PHCDm
reversible: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
product: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
is described by: ECO:0000304
reactant: MODEL1310110037#

metaM dgdp n
name: dGDP(2-)
is: HMDB00960
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58595
constant: false

metaM cdpdag hs m
name: CDP-diacylglycerol(2-)
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:58332
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078

metaR PRISTCOAtx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
name: pristcoa peroxisomal transport
reversible: true
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000000
product: MODEL1310110037#

metaM CE5236 n
has only substance units: false
is: HMDB03952
initial amount: NaN
constant: false
type: Species
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
is: CHEBI:28002
initial concentration: 1.0
is: SBO:0000247

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR RE3218C
is version of: http://identifiers.org/ec-code/3.1.6.2
type: Reaction
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
product: MODEL1310110037#
name: RE3218
is described by: ECO:0000000
kinetic law: MODEL1310110037#
is: SBO:0000176
reversible: true
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_25f671e7_6854_45f7_970a_aed6714e254d
type: Species
name: SGPP2
boundary condition: true
has only substance units: false
is encoded by: hsa:130367
is: SBO:0000252
constant: false
is: Q8IWX5
initial concentration: NaN
initial amount: NaN

metaM lnlncg r
initial amount: NaN
is: CHEBI:32391
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB03073
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
constant: false
type: Species
name: gamma-linolenate

metaR r2097
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110037#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM mi1p D n
is: HMDB02985
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:58433
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
name: 1D-myo-inositol 1-phosphate(2-)
boundary condition: false

metaR r0068
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.1
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
reactant: MODEL1310110037#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110037#

metaR ACHEe
is: SBO:0000176
reactant: MODEL1310110037#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.7
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
type: Reaction
name: Acetylcholinesterase
kinetic law: MODEL1310110037#
reversible: false
product: MODEL1310110037#
modifier: MODEL1310110037#

metaM oh1 e
initial concentration: 1.0
has only substance units: false
is: C01328
initial amount: NaN
type: Species
constant: false
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
is: SBO:0000247
is: HMDB01039
boundary condition: false

metaM dgtp n
has only substance units: false
is: HMDB01440
constant: false
is: CHEBI:16497
name: dGTP
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false
is: C00286
type: Species

metaM dgdp m
type: Species
is: CHEBI:58595
initial amount: NaN
boundary condition: false
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
name: dGDP(2-)
initial concentration: 1.0
constant: false
has only substance units: false

metaR r0522
reversible: false
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
fast: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10

metaM acmana e
name: N-acetyl-D-mannosamine
type: Species
constant: false
has only substance units: false
is: CHEBI:17122
is: HMDB01129
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: SBO:0000247
boundary condition: false

metaM chol e
boundary condition: false
name: Choline
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
initial concentration: 1.0
is: C00114
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:15354

http://identifiers.org/biomodels.db/MODEL1310110037#_85ed1927_d59e_4aa3_b9d8_d69bcddf1500
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:10449
is: SBO:0000252
name: ACAA2
is: P42765
constant: false

metaM h x
type: Species
name: proton
has only substance units: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: C00080
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_6ad848fb_d730_4dca_b1d1_ae5c058fc846
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AL525798
has only substance units: false
is: SBO:0000252
name: _AL525798_1_c

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM HC01406 m
initial concentration: 1.0
type: Species
initial amount: NaN
name: 3-Oxooctanoyl-CoA
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
is: CHEBI:28264
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_cbe0dcf7_d58b_4a15_a28e_4520da0bab58
initial concentration: NaN
constant: false
is encoded by: hsa:9187
initial amount: NaN
type: Species
is: B4DUG1
boundary condition: true
name: SLC24A1
has only substance units: false
is: SBO:0000252

metaM CE2431 m
constant: false
is: CHEBI:57795
type: Species
is: SBO:0000247
name: cis-deca-4-enoyl-CoA
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR r1116
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185

metaR CYTK10
fast: false
reactant: MODEL1310110037#
reversible: true
type: Reaction
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110037#
name: cytidylate kinase (CMP,dGTP)
product: MODEL1310110037#
is described by: ECO:0000269
is: SBO:0000176

metaR r2098
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR r2359
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaM leuktrC4 e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: leukotriene C4(2-)
constant: false
is: HMDB01198

metaR r0523
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2

metaR GCHOLAtx
product: MODEL1310110037#
name: bile acid intracellular transport
kinetic law: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false

metaM bilglcur r
type: Species
boundary condition: false
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:57767
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR LACLt
name: Lactate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
is described by: ECO:0000134
reactant: MODEL1310110037#
fast: false
type: Reaction
product: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
reversible: false

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_f6f0b2b8_3278_4e6d_ad6b_1f18bbf66910
initial concentration: NaN
name: LDHD
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:197257
has only substance units: false
is: Q86WU2

metaR PIACGT
reactant: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.83
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
is version of: http://identifiers.org/ec-code/2.4.1.198
is described by: ECO:0000000
modifier: MODEL1310110037#
product: MODEL1310110037#
name: phosphatidylinositol N-acetylglucosaminyltransferase

http://identifiers.org/biomodels.db/MODEL1310110037#_77bf5192_13b1_4e17_89dc_4dcb3e5d20aa
is encoded by: hsa:7371
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q9BZX2
name: UCK2

metaR SUCCtp
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: succinate transporter, peroxisome
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_de210ef9_cfd6_4cc7_a584_0bc05944de4f
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: O43175
is encoded by: hsa:26227
has only substance units: false
name: PHGDH
constant: false

metaR RE1516M
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110037#
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.99.13

http://identifiers.org/biomodels.db/MODEL1310110037#_6d3d040d_8729_484f_b0c0_d0ab722e89d9
is: Q53YB7
is encoded by: hsa:1329
initial concentration: NaN
name: COX5B
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR UDPGLCter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
type: Reaction
reversible: true
fast: false

metaR LEUTAm
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
name: leucine transaminase, mitochondrial

metaR r2099
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
fast: false
product: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaR RE2626C
product: MODEL1310110037#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
name: RE2626
reversible: true

metaM cit e
constant: false
is: CHEBI:16947
name: citrate(3-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
type: Species
initial amount: NaN
has only substance units: false

metaM dcacoa m
is: C05274
has only substance units: false
type: Species
is: CHEBI:61430
is: HMDB06404
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial amount: NaN
initial concentration: 1.0
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
is: SBO:0000247
boundary condition: false

metaR RE3243R
name: RE3243
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
product: MODEL1310110037#
is described by: ECO:0000000
modifier: MODEL1310110037#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110037#
is: SBO:0000176
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_1ef06eb6_3a13_4846_aca7_73dcb4a2cd6b
initial concentration: NaN
type: Species
is encoded by: hsa:4830
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: NME1

metaR RPI
name: ribose-5-phosphate isomerase
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/5.3.1.6
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP

http://identifiers.org/biomodels.db/MODEL1310110037#_a8ec9ee8_9cf0_48da_b378_9e843d67455f
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: _AA081045_1_e
constant: false
is encoded by: hsa:AA081045
type: Species
has only substance units: false
initial concentration: NaN

metaM chol c
type: Species
is: HMDB00097
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: Choline
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
initial amount: NaN
is: CHEBI:15354
has only substance units: false

metaR CYTK9n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110037#
name: cytidylate kinase (CMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_df389364_2d82_4b6f_a5df_6873e35285ac
initial concentration: NaN
is encoded by: hsa:100
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P00813
name: ADA
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_4f1be55c_ec3b_48e9_92ef_7632652c36c9
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AI348006
name: _AI348006_1_c

metaM stcoa m
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01114
type: Species
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: C00412
initial concentration: 1.0
is: CHEBI:57394

metaM oh1 c
type: Species
name: hydroxide ion
initial amount: NaN
is: HMDB01039
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C01328
notes: FORMULA: HO CHARGE: -1

metaR ACGAMPM
reversible: true
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110037#
fast: false
name: phosphoacetylglucosamine mutase
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/5.4.2.3
type: Reaction
modifier: MODEL1310110037#
is: SBO:0000176

metaR CDIPTr
modifier: MODEL1310110037#
name: phosphatidylinositol synthase (Homo sapiens)
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.8.11
reactant: MODEL1310110037#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is: SBO:0000176
kinetic law: MODEL1310110037#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_a19f5230_fffd_4874_91b5_3b78c82eb5f6
name: PYCRL
initial concentration: NaN
initial amount: NaN
is: Q53H96
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:65263

http://identifiers.org/biomodels.db/MODEL1310110037#_c1467e6b_0b25_4330_8401_e2aa44768428
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3948
is: SBO:0000252
name: LDHC
initial amount: NaN
type: Species
constant: false

metaR RE0577C
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
fast: false
reversible: true
modifier: MODEL1310110037#
name: RE0577
is described by: ECO:0000000
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_c8d39698_3bcb_4ea4_8bbc_eab6a7e85ef0
is: Q9UI40
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:25769
constant: false
name: SLC24A2
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r2092
modifier: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_90a28206_242d_4cd3_afb8_6ed7c223ffc6
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: PLCG1
is encoded by: hsa:5335
type: Species
is: P19174
boundary condition: true

metaR r2091
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_1615f198_26df_41a7_bcda_78791cd6c34a
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AA081045
name: _AA081045_1_m
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_0c18e8e1_4c48_4640_84c4_6c352f7cd653
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P07195
is encoded by: hsa:3945
constant: false
name: LDHB
boundary condition: true
type: Species
initial amount: NaN

metaM HC02207 e
has only substance units: false
constant: false
name: prostaglandin-c2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27555
type: Species

metaM leuktrC4 c
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
name: leukotriene C4(2-)
initial amount: NaN
is: HMDB01198
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57973

metaR HSD3A2r
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000000
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reversible: true
reactant: MODEL1310110037#
fast: false
is: SBO:0000176

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaM ura e
is: SBO:0000247
initial amount: NaN
is: CHEBI:17568
constant: false
type: Species
is: HMDB00300
has only substance units: false
name: uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
initial concentration: 1.0

metaM pan4p e
constant: false
name: Pantetheine 4'-phosphate
is: HMDB01416
initial amount: NaN
is: C01134
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
has only substance units: false
is: CHEBI:47942
type: Species
is: SBO:0000247

metaM 13dpg c
initial concentration: 1.0
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
type: Species
is: http://identifiers.org/pubchem.compound/3535
has only substance units: false
is: C00236
name: 3-Phospho-D-glyceroyl phosphate
boundary condition: false
is: HMDB01270
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57604

metaM spc hs c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
name: sphingosylphosphorylcholine
type: Species
is: http://identifiers.org/pubchem.compound/5311445

metaR r2093
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000000
reversible: true
product: MODEL1310110037#
is: SBO:0000185
modifier: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR TYRt4
is described by: ECO:0000304
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
fast: false
name: L-tyrosine transport in via sodium symport
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reversible: false
reactant: MODEL1310110037#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_5b840b01_4335_482c_ba83_18e8278fc9b0
boundary condition: true
has only substance units: false
name: UPP1
initial concentration: NaN
is encoded by: hsa:7378
type: Species
is: SBO:0000252
constant: false
is: Q16831
initial amount: NaN

metaM mgacpail hs r
is: HMDB00220
type: Species
is: CHEBI:7896
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
initial concentration: 1.0
is: C00249
constant: false

metaR NH4tn
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: ammonia nuclear transport
product: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
type: Reaction

metaM 4ppcys c
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:59458
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: C04352
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: SBO:0000247
is: HMDB01117
constant: false

metaM 6thf e
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
name: hexaglutamyl folate (THF)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/169691
is: SBO:0000247
boundary condition: false

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR DCK2n
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is: SBO:0000176
type: Reaction
name: Deoxycytidine kinase, nuclear (UTP)
fast: false

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM HC01376 m
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
initial amount: NaN
name: S-(2-Methylbutanoyl)-dihydrolipoamide
is: CHEBI:28692
boundary condition: false
has only substance units: false
type: Species

metaR ALAGLYexR
type: Reaction
is: SBO:0000185
reactant: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000304
modifier: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
name: L-alanine/glycine reversible exchange

metaM acnam n
type: Species
is: SBO:0000247
is: HMDB00230
is: CHEBI:35418
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false

metaR ACALDtm
product: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
name: acetaldehyde mitochondrial diffusion

http://identifiers.org/biomodels.db/MODEL1310110037#_54098be5_ed89_4991_bb77_9de65ab5721c
has only substance units: false
type: Species
boundary condition: true
name: FOLR1
is encoded by: hsa:2348
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_621607c0_45f1_47c9_92e7_f90855359d28
constant: false
name: ALDH4A1
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8659

metaR RETH
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110037#
reversible: false
type: Reaction
name: retinyl ester hydrolase
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
modifier: MODEL1310110037#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_deab1b2f_f0a1_44e1_8072_829eb4db3d94
is: Q546Y9
constant: false
has only substance units: false
is: SBO:0000252
name: AICDA
initial concentration: NaN
is encoded by: hsa:57379
initial amount: NaN
type: Species
boundary condition: true

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR GLCGLUT2
fast: false
is: SBO:0000185
name: Transport of glucose into the portal blood
reversible: true
reactant: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 71-74 NOTES:GLUT-2 can also move to the apical surface and aid in glucose import into the cell under fully fed state (PMID: 17786952)
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000134
type: Reaction

metaR r2094
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110037#
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110037#
reversible: true

metaR r0926
reversible: false
product: MODEL1310110037#
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_888b37b4_0c9c_4f79_90de_33cd0cab46ce
is encoded by: hsa:641649
is: SBO:0000252
has only substance units: false
type: Species
is: C9JZ62
initial concentration: NaN
name: TMEM91
boundary condition: true
initial amount: NaN
constant: false

metaR DHAAt1r
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
name: dehydroascorbate transport (uniport)
reversible: true
modifier: MODEL1310110037#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_823e676e_008e_4a24_9fa9_89c26b463fd2
initial concentration: NaN
boundary condition: true
name: RDH8
is: Q9NYR8
type: Species
has only substance units: false
is encoded by: hsa:50700
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_ed01298e_5e03_45b5_94fc_6818275f721c
constant: false
initial concentration: NaN
boundary condition: true
is: Q9H6R3
initial amount: NaN
has only substance units: false
is encoded by: hsa:79611
type: Species
name: ACSS3
is: SBO:0000252

metaM gly x
initial amount: NaN
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine
is: HMDB00123
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:15428

http://identifiers.org/biomodels.db/MODEL1310110037#_9ba70ca9_f09f_4e27_bffd_7ee247678cc8
is encoded by: hsa:9365
has only substance units: false
is: Q9UEF7
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: KL
is: SBO:0000252
type: Species
constant: false

metaR RPE
modifier: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/5.1.3.1
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110037#

metaM mag hs e
boundary condition: false
initial amount: NaN
is: CHEBI:32391
is: HMDB03073
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: monoacylglycerol 2

http://identifiers.org/biomodels.db/MODEL1310110037#_99684a6c_f827_4f10_9ef5_b7ebfdab65b9
type: Species
constant: false
name: MTHFD1L
is encoded by: hsa:25902
is: B2RD24
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM HC02207 c
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2
is: CHEBI:27555
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_aa57260a_c121_4348_a859_b8834e89b21d
is: Q8NFF5
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: FLAD1
is encoded by: hsa:80308
is: SBO:0000252
has only substance units: false

metaM ura c
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00300
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: C00106
name: Uracil
is: SBO:0000247
has only substance units: false
is: CHEBI:17568
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_9bac47c9_da5d_4b58_9120_a653122ac1ed
initial concentration: NaN
constant: false
is: Q96PD7
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: DGAT2
has only substance units: false
is encoded by: hsa:84649

metaM HC02206 e
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
boundary condition: false
is: SBO:0000247
is: CHEBI:57399
constant: false
name: prostaglandin C1(1-)
has only substance units: false
initial concentration: 1.0
type: Species

metaR DCYTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is: SBO:0000185
name: deoxycytidine transport via diffusion
fast: false

metaM h r
name: proton
is: SBO:0000247
is: CHEBI:24636
initial amount: NaN
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_df9e12f8_553a_4074_beb6_7b71397a9943
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1327
initial amount: NaN
initial concentration: NaN
name: COX4I1
is: P13073

metaM dc2coa m
boundary condition: false
initial concentration: 1.0
is: CHEBI:61406
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
constant: false
name: trans-Dec-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110037#_c68c2af3_372f_417b_a984_2339e3e44e09
boundary condition: true
is encoded by: hsa:1103
name: CHAT
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q6LEN5
type: Species

metaR r2095
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_e4799b19_53e3_48b9_a83f_b1ad3fd3c078
is encoded by: hsa:55
has only substance units: false
initial concentration: NaN
is: P15309
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: ACPP

http://identifiers.org/biomodels.db/MODEL1310110037#_659c853e_552a_4b40_b155_220391539d4d
type: Species
name: PAPSS2
is: SBO:0000252
is: O95340
constant: false
is encoded by: hsa:9060
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_6a1f8174_dbb5_47fa_a75d_5c98e996dcda
initial concentration: NaN
is encoded by: hsa:154091
is: SBO:0000252
constant: false
name: SLC2A12
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: Q8TD20

metaR NH4tp
reactant: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
name: ammonia peroxisomal transport
product: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#

metaR NDPK9n
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110037#
reversible: true
is: SBO:0000176
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false

metaR r1318
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185

metaM pan4p c
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
is: C01134
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01416
is: SBO:0000247
constant: false
name: Pantetheine 4'-phosphate
is: CHEBI:47942

http://identifiers.org/biomodels.db/MODEL1310110037#_81b14fe7_d769_4daa_b723_be3176b339f0
has only substance units: false
boundary condition: true
is: P07327
initial amount: NaN
is encoded by: hsa:124
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: ADH1A

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaM C05280 m
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
is: HMDB03952
type: Species
initial concentration: 1.0
name: cis,cis-3,6-Dodecadienoyl-CoA
boundary condition: false
is: CHEBI:28002

http://identifiers.org/biomodels.db/MODEL1310110037#_bd493838_6c58_4823_b3e5_b8d0a781eb08
is: Q9H0I9
has only substance units: false
name: TKTL2
is encoded by: hsa:84076
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_1e6e217f_51e8_4e87_af85_dbcda711e194
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q92643
is encoded by: hsa:10026
type: Species
has only substance units: false
name: PIGK
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_3ad0c237_d9f1_4593_a810_c8cb9996a81e
name: GGH
has only substance units: false
is: Q92820
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8836

metaR INSTt2r
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
fast: false
is described by: ECO:0000269
reactant: MODEL1310110037#
name: inositol transport in via proton symport
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction

metaM sph1p c
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
boundary condition: false
is: HMDB01383
is: CHEBI:57939
initial concentration: 1.0
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
has only substance units: false

metaR NDPK1m
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_c2e8a916_7fd9_4b1a_b659_bee13db7909c
has only substance units: false
type: Species
boundary condition: true
is: Q9H008
initial amount: NaN
constant: false
name: LHPP
initial concentration: NaN
is encoded by: hsa:64077
is: SBO:0000252

metaR r1563
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110037#

metaM gluala e
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 5-L-Glutamyl-L-alanine
is: HMDB06248
is: http://identifiers.org/pubchem.compound/6503
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: C03740
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaR GLXtm
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
product: MODEL1310110037#
reversible: true
name: glyoxylate transport, mitochondrial

metaR ADSK
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
fast: false
name: adenylyl-sulfate kinase
modifier: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110037#

metaM Rtotalcoa c
is: SBO:0000247
is: HMDB01448
is: CHEBI:16189
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
name: R total Coenzyme A
has only substance units: false
boundary condition: false

metaM CE2705 n
is: SBO:0000247
is: CHEBI:15374
has only substance units: false
is: HMDB02281
initial amount: NaN
name: quinonoid dihydrobiopterin
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
type: Species

metaM glyc3p c
initial amount: NaN
is: C00093
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
boundary condition: false
constant: false
name: Glycerol 3-phosphate
initial concentration: 1.0
has only substance units: false
is: CHEBI:57597
is: SBO:0000247
is: HMDB00126

metaM adn c
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:16335
is: HMDB00050
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
has only substance units: false
boundary condition: false
is: C00212
is: SBO:0000247
name: Adenosine

metaM HC02216 c
name: prostaglandin-f2beta
is: CHEBI:28922
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: SBO:0000247
constant: false

metaR NDPK1n
reversible: true
fast: false
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
modifier: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000134

metaR 3MOBte
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110037#
is: SBO:0000185
fast: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: Transport of 3-methyl-2-oxobutanoate
reactant: MODEL1310110037#

metaR DNDPt11m
is described by: ECO:0000269
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110037#
type: Reaction
name: dADP transport via dGDP antiport
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
fast: false
is: SBO:0000185

metaR NACHEX27ly
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110037#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: false

metaM HC02203 c
name: prostaglandin-a2
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:27820

metaR r1564
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
fast: false

metaM tcynt m
constant: false
is: HMDB01453
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
name: thiocyanate
is: CHEBI:18022

metaR FATP3t
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
type: Reaction
is: SBO:0000185
name: fatty acid electroneutral transport
reactant: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_4878c05e_93ac_4222_8fc1_081cddb584a3
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:D87002
has only substance units: false
constant: false
name: _D87002_1_m
initial amount: NaN

metaR r2014
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM xol27oh m
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:17703
has only substance units: false
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
name: 26-hydroxycholesterol
is: HMDB02103
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_6589e584_f917_4540_837f_22d1aabe554b
is encoded by: hsa:84720
initial concentration: NaN
name: PIGO
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_04f49dfe_4406_4d02_b665_c1faa79824f9
is: SBO:0000252
name: PLCD4
type: Species
initial amount: NaN
has only substance units: false
is: Q9BRC7
initial concentration: NaN
is encoded by: hsa:84812
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_8a35f86d_b254_480a_ba76_57de28f31b45
has only substance units: false
initial concentration: NaN
name: NDUFS8
initial amount: NaN
type: Species
boundary condition: true
is: O00217
is encoded by: hsa:4728
constant: false
is: SBO:0000252

metaR r0780
reactant: MODEL1310110037#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
product: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_51c21110_56f0_4895_af7d_8c109673e9c4
type: Species
is encoded by: hsa:123041
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC24A4
initial amount: NaN
constant: false
is: SBO:0000252

metaR ACACT1rm
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
is: SBO:0000176
reactant: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r0937
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110037#
name: Transport reaction
kinetic law: MODEL1310110037#
type: Reaction
fast: false

metaR r1561
reactant: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR AK2LGCHOLt
product: MODEL1310110037#
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
reversible: true
is: SBO:0000185
reactant: MODEL1310110037#
is described by: ECO:0000269
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
type: Reaction
fast: false

metaM sph1p e
has only substance units: false
constant: false
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
boundary condition: false
is: HMDB01383
is: CHEBI:57939
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_16af5d16_e47d_4fd0_ad81_ec890ec5c2fa
type: Species
name: CDS2
is: O95674
is encoded by: hsa:8760
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM chlstol r
initial amount: NaN
type: Species
boundary condition: false
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: CHEBI:16290
initial concentration: 1.0
is: SBO:0000247
name: 5alpha-cholesta-7,24-dien-3beta-ol
has only substance units: false
is: HMDB06842

http://identifiers.org/biomodels.db/MODEL1310110037#_9f0f0b08_8a85_45d1_b612_7ae6539b109d
boundary condition: true
name: ADSL
initial concentration: NaN
is encoded by: hsa:158
has only substance units: false
is: P30566
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_ce4b84d7_7336_4d65_866e_5629a9f5f622
is encoded by: hsa:6648
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
name: SOD2
boundary condition: true
is: P04179
constant: false

metaR ATP2ter
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: AMP/ATP transporter, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110037#_74d67ad2_901b_4607_80fb_c78b65495926
initial amount: NaN
initial concentration: NaN
is: P42765
name: ACAA2
type: Species
has only substance units: false
is encoded by: hsa:10449
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_e58ecca0_36f8_430a_aa64_c78323248a03
constant: false
is encoded by: hsa:50
type: Species
boundary condition: true
name: ACO2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q99798
initial amount: NaN

metaR RE1903R
name: RE1903
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is: SBO:0000176
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true

metaM HC02203 e
is: CHEBI:27820
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
name: prostaglandin-a2
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR r0892
modifier: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.2.27
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
fast: false
product: MODEL1310110037#
is: SBO:0000185
name: Facilitated diffusion

metaR r1562
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
fast: false

metaM sphmyln hs c
initial concentration: 1.0
notes: FORMULA: CHARGE: 0
is: SBO:0000247
is: HMDB00067
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
name: sphmyln_hs[c]

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR r0470
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
type: Reaction
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
is: SBO:0000176
kinetic law: MODEL1310110037#

metaR PTPATe
is: SBO:0000176
reversible: true
product: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
name: PTPATe
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110037#_b903789b_8887_413c_9ac9_4bb28caefb02
constant: false
boundary condition: true
type: Species
name: LDHA
is: SBO:0000252
is encoded by: hsa:3939
initial concentration: NaN
is: P00338
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_73d51ca1_c569_48e0_a21d_84dd279be499
is: SBO:0000252
type: Species
is encoded by: hsa:X63359
has only substance units: false
constant: false
name: _X63359_1_c
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM dgsn c
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00085
name: Deoxyguanosine
boundary condition: false
initial concentration: 1.0
is: C00330
constant: false
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
type: Species

metaR XOL7AH2tm
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
product: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#

metaR PHETHPTOX2
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
is version of: http://identifiers.org/ec-code/1.14.16.1
is: SBO:0000176
product: MODEL1310110037#
is described by: ECO:0000269
modifier: MODEL1310110037#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM ach n
type: Species
is: HMDB00895
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: acetylcholine

metaR SUCOAS1m
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: Succinate--CoA ligase (GDP-forming)
is: SBO:0000176
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reactant: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
reversible: true

metaM trp L e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16828
name: L-tryptophan
initial amount: NaN
constant: false
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false

metaM malthp e
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
constant: false
type: Species
is: SBO:0000247
is: C01936
has only substance units: false
name: maltoheptaose
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
boundary condition: false
initial amount: NaN

metaR r1567
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

metaR r0899
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
type: Reaction
name: Amino acid transporter ATB0+ Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:

metaR GLUCYS
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.2
kinetic law: MODEL1310110037#
name: Gamma-glutamylcysteine synthetase
notes: GENE_ASSOCIATION: (2729.1) and (2730.1) SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
fast: false
reversible: false
reactant: MODEL1310110037#

metaR r1088
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Active transport
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110037#

metaR PAIL45P HStn
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110037#_146de705_04c8_469e_8b4a_1cda98982fce
boundary condition: true
initial concentration: NaN
name: LDHB
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3945
constant: false
is: P07195
initial amount: NaN

metaR ALAtN1
kinetic law: MODEL1310110037#
name: Alanine transport (Na, H coupled)
product: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_a3bea269_8118_4aea_807c_1d06d6c58db7
initial amount: NaN
type: Species
name: GCDH
constant: false
is encoded by: hsa:2639
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q92947

http://identifiers.org/biomodels.db/MODEL1310110037#_2eef2277_ac07_45f7_9dd8_b3fd8eb3bccc
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ALDOA
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:226

metaM arachdcoa c
initial concentration: 1.0
has only substance units: false
name: arachidonoyl-CoA(4-)
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species
is: HMDB06523
boundary condition: false
is: CHEBI:57368

metaM val L c
name: L-valine
is: HMDB00883
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:16414
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_c769f6f2_9cd5_40bb_90b4_c2cb61f94ba8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: Q9NQR4
is encoded by: hsa:56954
name: NIT2
initial amount: NaN
constant: false
has only substance units: false

metaM ethamp c
name: ethamp[c]
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:58190
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
constant: false
boundary condition: false
is: HMDB00224

metaM arachcoa c
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB04258
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:15527
name: arachidyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110037#_f5eb4a4c_bf62_49e4_a008_bdb39adec5f0
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:1109
name: AKR1C4
is: P17516
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_0bacca4c_265c_4679_9df8_53d44e44a33a
is: P21108
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:221823
name: PRPS1L1

metaR BPNT
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.3.7
reversible: false
name: 3',5'-bisphosphate nucleotidase
modifier: MODEL1310110037#
product: MODEL1310110037#
fast: false
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000176

metaM gcald c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB03344
type: Species
name: glycolaldehyde
is: CHEBI:17071
constant: false
initial amount: NaN
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266

metaM dttp e
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
is: CHEBI:37568
is: SBO:0000247
is: HMDB01342
initial concentration: 1.0
has only substance units: false
name: dTTP(4-)

http://identifiers.org/biomodels.db/MODEL1310110037#_f362e8b9_05e0_410d_8cec_1f8b16a2e959
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:768
is: Q16790
name: CA9
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_b9ea85e4_ff3b_4273_86a0_9a18f45c2218
has only substance units: false
is encoded by: hsa:AA021081
initial amount: NaN
type: Species
initial concentration: NaN
name: _AA021081_1_r
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_27cf2d28_84cc_4bb6_a468_d7181ef850f9
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55967
is: SBO:0000252
name: NDUFA12
boundary condition: true
is: F8VQS7
has only substance units: false
constant: false

metaM pro D c
initial amount: NaN
is: HMDB03411
is: SBO:0000247
is: CHEBI:16313
boundary condition: false
name: D-proline
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false
constant: false
type: Species

metaR r1568
reversible: true
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0936
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110037#
name: Transport reaction
product: MODEL1310110037#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110037#

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR ACCOAC
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_158d9f37_eec7_4f97_9dd4_25a64723d578
type: Species
name: PCBD2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:84105
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: Q9H0N5

http://identifiers.org/biomodels.db/MODEL1310110037#_77f1cef0_f597_4e46_8389_497b439e6022
type: Species
initial concentration: NaN
has only substance units: false
name: _U37519_1_e
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:U37519

http://identifiers.org/biomodels.db/MODEL1310110037#_00c79a11_0fa0_483e_ac6a_dd5fd6697358
boundary condition: true
is: P30838
is encoded by: hsa:218
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: ALDH3A1
constant: false

metaM gumtchol e
has only substance units: false
is: HMDB00626
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C2760026H5060045NO2530007S CHARGE: 0
name: guar gum-taurocholic acid complex

metaM CE0693 m
has only substance units: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110037#_1612c055_ddf6_408b_8eae_f99745f48526
initial amount: NaN
is encoded by: hsa:AI824319
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
name: _AI824319_1_r
initial concentration: NaN
constant: false

metaM HC01412 m
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: SBO:0000247
initial concentration: 1.0
constant: false
name: trans-tetradec-2-enoyl-CoA(4-)
is: CHEBI:61405

metaR PROSTGE2t
product: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000185
fast: false
reactant: MODEL1310110037#
reversible: true
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110037#_e14de5be_bb83_4752_9bed_0a6f9160ede7
name: NDUFS3
type: Species
is: O75489
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:4722
is: SBO:0000252

metaR r0186
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
modifier: MODEL1310110037#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_53b772d8_7e3a_4f5d_8901_34cf910a8b0a
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:292
is: Q6NVC0
type: Species
initial concentration: NaN
name: SLC25A5
has only substance units: false
boundary condition: true
constant: false

metaR r1565
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
product: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

metaR r2197
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110037#

metaR ARACHDCOAtx
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
name: fatty acid intracellular transport
kinetic law: MODEL1310110037#

metaM HC02216 e
is: CHEBI:28922
type: Species
initial amount: NaN
name: prostaglandin-f2beta
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
is: SBO:0000247

metaM pe hs r
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:16038
has only substance units: false
type: Species
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0

metaM pchol hs m
is: CHEBI:16110
constant: false
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
name: Phosphatidylcholine
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_01a8be1e_8f21_42a9_9daf_6ba1078a5a12
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9NY65
boundary condition: true
constant: false
is encoded by: hsa:1962
name: EHHADH

http://identifiers.org/biomodels.db/MODEL1310110037#_b33cfafa_cf4c_4f42_8554_73da1c9728e3
boundary condition: true
constant: false
initial concentration: NaN
name: BAAT
type: Species
initial amount: NaN
is encoded by: hsa:570
is: SBO:0000252
is: Q14032
has only substance units: false

metaR GCALDD
modifier: MODEL1310110037#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
name: Glycolaldehyde dehydrogenase
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR

metaM glyc R c
is: CHEBI:16659
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
constant: false
initial concentration: 1.0
initial amount: NaN
name: D-glycerate
boundary condition: false
is: HMDB00139

http://identifiers.org/biomodels.db/MODEL1310110037#_e2db4dd2_b0fe_4d3a_949e_c576dc196566
is: SBO:0000252
initial amount: NaN
is: Q16762
name: TST
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:7263

metaR DURItn
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110037#
reversible: true
fast: false
name: deoxyuridine transport in nucleus
type: Reaction

metaR H2CO3D
product: MODEL1310110037#
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
type: Reaction
reactant: MODEL1310110037#
modifier: MODEL1310110037#
name: carboxylic acid dissociation
is: SBO:0000176

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_6324c7b4_2a41_46bc_bbf8_da3d4a53ce31
is encoded by: hsa:6567
initial concentration: NaN
boundary condition: true
name: SLC16A2
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P36021
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_9e9a0838_d9c3_4079_b56f_a0fd1cd953ed
type: Species
is encoded by: hsa:8833
name: GMPS
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is: P49915
initial concentration: NaN

metaM 5thf e
is: HMDB06487
notes: FORMULA: C39H45N11O18 CHARGE: -6
has only substance units: false
name: pentaglutamyl folate (THF)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species

metaM maltpt e
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
boundary condition: false
initial amount: NaN
is: C02052
constant: false
initial concentration: 1.0
type: Species
is: HMDB01296
name: maltopentaose
has only substance units: false

metaR r2198
fast: false
is: SBO:0000185
modifier: MODEL1310110037#
product: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaR r1566
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

metaR r2347
product: MODEL1310110037#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110037#
name: Organic anion transporter 5 Utilized transport
fast: false

metaR GLYt2r
reactant: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
reversible: true
name: glycine reversible transport via proton symport
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110037#

metaM retinal 11 cis c
initial concentration: 1.0
initial amount: NaN
is: HMDB02152
has only substance units: false
type: Species
name: 11-cis-retinal
is: SBO:0000247
is: CHEBI:16066
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false

metaR r0027
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
reversible: true
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is: SBO:0000176
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:

metaR GMPR
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
product: MODEL1310110037#
name: GMP reductase
reactant: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.7.1.7
type: Reaction

metaM 34dhoxmand c
is: HMDB01866
name: 3,4-Dihydroxymandelate
constant: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:27637

http://identifiers.org/biomodels.db/MODEL1310110037#_0ca79381_334a_4f5d_b37d_f1f78dafd3f1
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:H53099
constant: false
name: _H53099_1_m
boundary condition: true

metaR FPGS7m
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
reversible: false
fast: false
modifier: MODEL1310110037#
is: SBO:0000176
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
name: folylpolyglutamate synthetase (10fthf), mitochondrial
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.3.2.17

http://identifiers.org/biomodels.db/MODEL1310110037#_c0fefe6b_445d_4d48_9b42_14077924e552
constant: false
name: SLC5A2
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:6524
initial amount: NaN
is: SBO:0000252
is: P31639

metaR LYStip
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
type: Reaction
reactant: MODEL1310110037#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: L-lysine transport, peroxisomal (irreversible)
is: SBO:0000185

metaR LALDO2x
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
kinetic law: MODEL1310110037#
fast: false
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
product: MODEL1310110037#
is described by: ECO:0000269
modifier: MODEL1310110037#
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110037#

metaM CE5786 e
type: Species
name: kinetensin
is: CHEBI:27485
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
is: HMDB02710
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3ea17381_e49b_4f68_bbf8_1d0799151380
type: Species
is encoded by: hsa:T83654
initial concentration: NaN
constant: false
is: SBO:0000252
name: _T83654_1_e
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_7095c90a_f5bd_4340_a965_9fcfcff6a9b2
is encoded by: hsa:51196
name: PLCE1
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9P212
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_fe297419_b02e_4317_9ef1_6a429b111222
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: PYCR1
is encoded by: hsa:5831
is: A6NFM2
initial amount: NaN
initial concentration: NaN

metaM din e
name: Deoxyinosine
is: HMDB00071
is: CHEBI:28997
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: C05512
constant: false
has only substance units: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512

metaR THP2Ctp
type: Reaction
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
reactant: MODEL1310110037#
fast: false
is: SBO:0000185
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: true

metaR r0789
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

metaR ACOAD1fm
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
product: MODEL1310110037#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
type: Reaction
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
fast: false

metaR GGH 10FTHF6GLUl
name: Gamma-glutamyl hydrolase (10FTHF6GLU), lysosomal
reversible: false
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
modifier: MODEL1310110037#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR RE1522M
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
modifier: MODEL1310110037#
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1522
product: MODEL1310110037#
reactant: MODEL1310110037#

metaM HC00695 m
is: CHEBI:17432
type: Species
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: S-Succinyldihydrolipoamide
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_725906fc_63c4_42f1_a575_b041e16d5fd5
is: Q9H6Y6
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: MYO5B
is encoded by: hsa:4645
type: Species

metaM HC02175 c
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
type: Species
has only substance units: false
initial amount: NaN
name: caprate
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:27689

metaM udpglcur c
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58052
name: UDP-D-glucuronate
boundary condition: false
initial concentration: 1.0
is: HMDB00935
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167

http://identifiers.org/biomodels.db/MODEL1310110037#_7477c0da_8d15_4355_8cab_00a78b42cc17
boundary condition: true
is encoded by: hsa:1109
is: P17516
initial concentration: NaN
type: Species
is: SBO:0000252
name: AKR1C4
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_6e9d4f3c_bb5d_4106_840e_63e8b86a73a8
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q6PII5
constant: false
is encoded by: hsa:84264
has only substance units: false
name: HAGHL

metaM pristcoa c
name: pristanoyl coa
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
constant: false
is: CHEBI:51341
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR RE1845X
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: RE1845
reversible: true
kinetic law: MODEL1310110037#

metaR RE1233C
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
modifier: MODEL1310110037#
name: RE1233
type: Reaction
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110037#
fast: false

metaM 3oddcoa m
name: 3-Oxododecanoyl-CoA
has only substance units: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27868
initial amount: NaN
is: HMDB03937
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_a390e440_49b2_4335_8634_d261a0a1c05f
name: ALDH7A1
initial amount: NaN
is: SBO:0000252
is: E7EPT3
initial concentration: NaN
is encoded by: hsa:501
boundary condition: true
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_8840423d_ac2d_408d_a3e4_ed9ec49a5665
name: PLCH2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9651
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: O75038
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_f8f331c8_ceb0_405f_8904_0cc55d5254b8
is: SBO:0000252
name: GNPDA1
has only substance units: false
constant: false
is encoded by: hsa:10007
type: Species
initial concentration: NaN
is: P46926
initial amount: NaN
boundary condition: true

metaR RE1533M
type: Reaction
name: RE1533
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR NH4t3r
modifier: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000269
name: ammonia transport via proton antiport
fast: false
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_5e28f848_d898_415c_8544_68c30d8aef1e
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:10568
type: Species
is: O95436
name: SLC34A2
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_508783bd_a5b9_4f55_958d_4daa0816566a
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:5277
constant: false
boundary condition: true
type: Species
name: PIGA
is: SBO:0000252

metaR MI145PP
kinetic law: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.56
modifier: MODEL1310110037#
is described by: ECO:0000269
fast: false
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.86
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.3.36

metaM ptth m
constant: false
is: HMDB03426
is: CHEBI:16753
boundary condition: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial amount: NaN
has only substance units: false
name: pantetheine
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r2088
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
type: Reaction

metaR r0788
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
modifier: MODEL1310110037#
reactant: MODEL1310110037#

metaM trp L c
boundary condition: false
type: Species
is: HMDB00929
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
name: L-tryptophan
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_93573a8b_d744_443c_a8ee_4d7e39b94aa8
initial concentration: NaN
name: FOLR1
is encoded by: hsa:2348
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species

metaM fald c
has only substance units: false
type: Species
is: CHEBI:16842
is: HMDB01426
name: formaldehyde
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067

metaR INSTt4 2
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000006
is: SBO:0000185
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
type: Reaction
name: inositol transport via sodium symport
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true

metaR r1569
reactant: MODEL1310110037#
fast: false
product: MODEL1310110037#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110037#

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_9266672a_18da_44db_9468_5192367b6af5
has only substance units: false
constant: false
type: Species
is: SBO:0000297
is encoded by: hsa:8140
boundary condition: true
initial concentration: NaN
name: SLC3A2:SLC7A5
initial amount: NaN
has part: Q8IV97

http://identifiers.org/biomodels.db/MODEL1310110037#_64b1c7f1_dabf_46a2_81f5_41e72657c807
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ACP6
type: Species
constant: false
is: Q9NPH0
initial amount: NaN
is encoded by: hsa:51205

http://identifiers.org/biomodels.db/MODEL1310110037#_f78b4157_4f6e_440b_9ffb_12d5e59bfba4
is: Q5JPH6
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: EARS2
is encoded by: hsa:124454

metaM dcmp c
is: HMDB01202
initial amount: NaN
name: dCMP
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: CHEBI:57566
constant: false
is: SBO:0000247
boundary condition: false
is: C00239
type: Species
has only substance units: false

metaR r0181
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110037#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_dc3bf5d5_b46b_403f_b92a_a447985aa87e
is encoded by: hsa:56922
is: Q96RQ3
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: MCCC1

metaM CE2705 c
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: quinonoid dihydrobiopterin
boundary condition: false
is: CHEBI:36781
is: SBO:0000247

metaR r2089
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_7af039b5_de43_4bd2_b059_a1f796a89778
constant: false
name: PANK4
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:55229
has only substance units: false
is: Q9NVE7
is: SBO:0000252
boundary condition: true

metaM dttp c
type: Species
is: HMDB01342
is: CHEBI:37568
initial concentration: 1.0
name: dTTP
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
is: C00459
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_fd89d82d_a5bc_408c_be49_9eefbd1ff9eb
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: E2QC23
is encoded by: hsa:23464
has only substance units: false
boundary condition: true
name: GCAT

metaM imp c
constant: false
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: SBO:0000247
is: C00130
is: HMDB00175
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: IMP
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_6f4a3385_ef4d_4672_b956_caae2bb238cb
is: SBO:0000252
type: Species
constant: false
is: Q6FH48
has only substance units: false
initial amount: NaN
name: ASPA
initial concentration: NaN
is encoded by: hsa:443
boundary condition: true

metaR r0787
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
reversible: false
is described by: ECO:0000000
product: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000176
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction

metaM val L e
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
is: HMDB00883
constant: false
name: L-valine
type: Species
initial concentration: 1.0

metaR LNLCCRNt
is: SBO:0000185
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110037#
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR SPODMx
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110037#
reversible: false
type: Reaction
product: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
name: superoxide dismutase, peroxisome
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.15.1.1

http://identifiers.org/biomodels.db/MODEL1310110037#_a1617112_384a_494e_9f29_3cf1cf64b9f0
name: SDHB
is: SBO:0000252
type: Species
is: P21912
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6390
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_2b9261b3_9db6_4c6b_851b_2779140fa361
name: CHKB
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1120
is: Q9Y259

http://identifiers.org/biomodels.db/MODEL1310110037#_36020bcb_a75c_4046_984f_7f7e64c2e000
name: NT5E
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4907
constant: false
is: P21589
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_f1375a00_1c7b_43e4_80d7_16293c11dc99
boundary condition: true
is: Q8TDB8
initial amount: NaN
has only substance units: false
is encoded by: hsa:144195
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: SLC2A14

http://identifiers.org/biomodels.db/MODEL1310110037#_0c6cc540_c86b_4b7f_b54e_cfa3b159f6fc
initial amount: NaN
is encoded by: hsa:64902
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9BYV1
name: AGXT2

metaR TRDR
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
reactant: MODEL1310110037#
name: thioredoxin reductase (NADPH)
is described by: ECO:0000269
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.9

metaR r1639
reversible: true
modifier: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
fast: false

metaR GLYSARCNc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
is: C06028
constant: false
type: Species
is: CHEBI:27969
initial concentration: 1.0
initial amount: NaN
name: Mesaconyl-CoA
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r1908
product: MODEL1310110037#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110037#
fast: false
reversible: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_90de4d53_025d_441e_8a59_6b3895c716fa
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:80025
type: Species
name: PANK2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_5a7f1ece_93cb_461d_954d_3342b6ff441c
constant: false
boundary condition: true
is: Q9HBH5
is: SBO:0000252
has only substance units: false
is encoded by: hsa:57665
initial amount: NaN
name: RDH14
type: Species
initial concentration: NaN

metaM lthstrl r
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: HMDB01170
boundary condition: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
name: 5alpha-cholest-7-en-3beta-ol
is: CHEBI:17168
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_81a37cb4_8f35_4db4_bd63_95006b97f8c4
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:171425
name: CLYBL
is: SBO:0000252

metaR RE2649C
name: RE2649
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000176
reactant: MODEL1310110037#
is described by: ECO:0000000

metaR GLXtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
name: glyoxylate transport, peroxisomal
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110037#

metaR URIt
is: SBO:0000185
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: uridine facilated transport in cytosol
fast: false
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
modifier: MODEL1310110037#
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110037#

metaM srtn c
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:350546
name: serotonin(1+)
initial amount: NaN
is: SBO:0000247
is: HMDB00259
initial concentration: 1.0
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780

http://identifiers.org/biomodels.db/MODEL1310110037#_2692c406_25be_44c0_ae03_1e487da25c2b
initial amount: NaN
is: SBO:0000252
name: AKR1A1
constant: false
type: Species
is encoded by: hsa:10327
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P14550

http://identifiers.org/biomodels.db/MODEL1310110037#_f9212007_aa79_413f_b9ef_0c8b3aaa194f
is: SBO:0000252
initial amount: NaN
is: Q9NT06
name: HMGCLL1
is encoded by: hsa:54511
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR GLYCTDle
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: difussion of glycerol accross the brush border membrane
kinetic law: MODEL1310110037#
is described by: ECO:0000134
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_7d0b5045_6868_4457_a2e3_93e2ba561a53
type: Species
is: SBO:0000297
name: PFKM:PFKP
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:5213
has part: P08237
boundary condition: true
initial concentration: NaN

metaM glyc R m
initial amount: NaN
type: Species
is: CHEBI:16659
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
constant: false
is: SBO:0000247
name: D-glycerate
boundary condition: false
is: HMDB00139

http://identifiers.org/biomodels.db/MODEL1310110037#_8e1e4a04_6dd4_483f_a83d_ef9e4fa8cfe0
has part: P31350
is encoded by: hsa:6241
name: RRM1:RRM2
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:6240
boundary condition: true
has only substance units: false
type: Species
has part: P23921
initial concentration: NaN
constant: false

metaM gtp m
boundary condition: false
type: Species
is: HMDB01273
has only substance units: false
name: GTP
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00044
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
initial amount: NaN

metaR r1638
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_c8595666_a912_4c91_bc25_720983976c86
initial concentration: NaN
has only substance units: false
name: _728226_1_e
is encoded by: hsa:728226
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_004b362e_de41_4cad_b62a_939269ef4af2
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC1A7
type: Species
initial concentration: NaN
is encoded by: hsa:6512
boundary condition: true
constant: false
is: O00341

metaR PUNP1
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110037#
type: Reaction
name: purine-nucleoside phosphorylase (Adenosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
reactant: MODEL1310110037#

metaR r2119
product: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_1a2c1207_4a6c_482a_9ab9_7bd0fe7ed8d9
boundary condition: true
is: Q6ZWP6
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:27034
initial amount: NaN
has only substance units: false
name: ACAD8

http://identifiers.org/biomodels.db/MODEL1310110037#_2d5f01c6_63f1_48bf_a221_237501a272a3
is: SBO:0000252
is encoded by: hsa:1962
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: EHHADH
type: Species
is: Q9NY65
initial concentration: NaN

metaR r2118
fast: false
product: MODEL1310110037#
reversible: true
is: SBO:0000185
modifier: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM 7dhf e
name: heptaglutamyl folate (DHF)
type: Species
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
is: HMDB06559
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

metaR ARACHDt2
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110037#

metaR MAL Lte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: Transport of L-malate
is: SBO:0000185
reactant: MODEL1310110037#
fast: false
reversible: true

metaM xol27oh r
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
name: 26-hydroxycholesterol
constant: false
type: Species
is: SBO:0000247
is: CHEBI:17703
initial concentration: 1.0
boundary condition: false
is: HMDB02103
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_e932a51c_c176_4505_b35f_965579524ab7
initial amount: NaN
is encoded by: hsa:224
boundary condition: true
has only substance units: false
initial concentration: NaN
name: ALDH3A2
is: P51648
is: SBO:0000252
type: Species
constant: false

metaR r0784
type: Reaction
fast: false
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
modifier: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
product: MODEL1310110037#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_31872e03_a83c_49f5_a3cc_28f41f5e0f41
constant: false
name: RRM2B
type: Species
is: Q7LG56
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:50484
initial concentration: NaN

metaM gtp n
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
constant: false
name: GTP(4-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:37565
type: Species
is: HMDB01273

http://identifiers.org/biomodels.db/MODEL1310110037#_bf7dbb75_6ab0_4eec_bd77_de81db44babe
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54995
has only substance units: false
is: Q9NWU1
name: OXSM

metaR GLUDxm
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NAD) (mitochondrial)
is: SBO:0000176
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/1.4.1.3
fast: false
modifier: MODEL1310110037#
type: Reaction

metaM srtn e
initial concentration: 1.0
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:350546
initial amount: NaN
is: SBO:0000247
name: serotonin(1+)
is: HMDB00259
constant: false

metaR r0829
is: SBO:0000185
modifier: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.1.37
reversible: true
product: MODEL1310110037#

metaM HC01223 m
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: CHEBI:57340
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR r2117
product: MODEL1310110037#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110037#
reversible: true
is described by: ECO:0000000
fast: false

metaM HC02175 e
type: Species
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial amount: NaN
constant: false
has only substance units: false
name: caprate
is: SBO:0000247
is: CHEBI:27689
initial concentration: 1.0
boundary condition: false

metaM xtsn c
name: xanthosine
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: CHEBI:18107
is: HMDB00299
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_321f1b39_e0f7_4a0e_8db5_db4209bbbf32
initial amount: NaN
is: B3KTV4
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:122622
type: Species
name: ADSSL1
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_673a8a57_90de_46d9_b384_a5a88141089c
is: Q96NR8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:145226
is: SBO:0000252
has only substance units: false
name: RDH12
constant: false
type: Species
initial amount: NaN

metaM din c
constant: false
is: CHEBI:28997
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
name: Deoxyinosine
type: Species
boundary condition: false
has only substance units: false
is: C05512
is: HMDB00071

http://identifiers.org/biomodels.db/MODEL1310110037#_db400aeb_db06_474c_b4c0_1d37c0d753a6
boundary condition: true
constant: false
is: Q99798
name: ACO2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:50
initial amount: NaN

metaM adn e
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: C00212
is: CHEBI:16335
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: Adenosine
boundary condition: false
is: HMDB00050
has only substance units: false
constant: false

metaR r0783
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110037#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_3c3bb62a_7288_4856_84d2_d0ab29f6e251
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:AI934540
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _AI934540_1_c

metaM dcsptn1crn m
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial amount: NaN
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
is: HMDB06321
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_5fbbf754_e9f3_4431_87dd_0ad2a49dfde7
name: PLCD1
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5333
type: Species
is: P51178
is: SBO:0000252
initial amount: NaN
constant: false

metaM for c
is: HMDB00142
initial amount: NaN
boundary condition: false
constant: false
is: C00058
initial concentration: 1.0
name: Formate
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:15740

metaM HC02205 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
name: prostaglandin-b2
initial concentration: 1.0
is: CHEBI:28099
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_76072122_9823_4d76_86cc_b5d4c9fe20d3
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10449
boundary condition: true
name: ACAA2
is: P42765
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_7d2f03b7_3482_422a_ac21_fe7036952e73
boundary condition: true
type: Species
is: Q9BV10
initial concentration: NaN
has only substance units: false
name: ALG12
initial amount: NaN
is encoded by: hsa:79087
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_74f22d71_632a_4ebf_a686_34e9c1032379
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is: Q96P26
initial concentration: NaN
name: NT5C1B
is encoded by: hsa:93034
has only substance units: false
initial amount: NaN

metaR AHCYStd
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000134
fast: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
type: Reaction
name: diffusion of S-Adenosyl-L-homocysteine

metaM alpam m
is: SBO:0000247
type: Species
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: HMDB06239
name: S-aminomethyldihydrolipoamide
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaM ribflv e
is: HMDB00244
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: C00255
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:3554
initial concentration: 1.0
type: Species
name: Riboflavin
boundary condition: false
is: SBO:0000247

metaR r2083
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110037#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_9d68de89_036e_4387_8ef0_6920a678d464
has only substance units: false
is encoded by: hsa:249
initial amount: NaN
is: B7Z4Y6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: ALPL

metaR r1634
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true

metaM his L m
has only substance units: false
is: CHEBI:15971
boundary condition: false
type: Species
name: L-histidine
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM HC01496 m
name: 2-Amino-3-oxoadipate
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:28095
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaM ctp c
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00082
is: C00063
initial amount: NaN
boundary condition: false
type: Species
name: CTP
is: CHEBI:37563
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaM pchol hs c
name: pchol_hs[c]
initial amount: NaN
is: HMDB00156
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: CHARGE: 0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:15589

metaM strch1 e
initial amount: NaN
has only substance units: false
notes: FORMULA: C66H112O56 CHARGE: 0
is: C00020
initial concentration: 1.0
is: HMDB00045
is: CHEBI:456215
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaR r2127
fast: false
product: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_c5448b6f_da39_4fc5_a8a7_16475cf55295
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: NDUFS1
is encoded by: hsa:4719
type: Species
is: SBO:0000252
is: P28331
initial amount: NaN

metaM andrstrn r
is: CHEBI:16032
type: Species
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial concentration: 1.0
has only substance units: false
is: HMDB00031
initial amount: NaN
boundary condition: false
name: androsterone
constant: false
is: SBO:0000247

metaR H2Oter
kinetic law: MODEL1310110037#
name: H2O endoplasmic reticulum transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r1635
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction

metaM 3otdcoa m
is: HMDB03935
has only substance units: false
name: 3-Oxotetradecanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
constant: false
boundary condition: false
is: CHEBI:28726
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_07901cba_a9c1_42bc_a6a2_9a3c2007bb29
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: _100287639_1_c
is: SBO:0000252
is encoded by: hsa:100287639
has only substance units: false

metaM nad r
boundary condition: false
is: CHEBI:57540
is: HMDB00902
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial amount: NaN
constant: false
name: NAD(1-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR THYOXt2
type: Reaction
is: SBO:0000185
modifier: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269
fast: false
name: T4 transport via facilitated diffusion

metaR GGH 10FTHF6GLUe
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110037#
type: Reaction

metaM h2o c
has only substance units: false
boundary condition: false
is: C00001
is: CHEBI:3303
name: H2O
notes: FORMULA: H2O CHARGE: 0
constant: false
initial amount: NaN
is: HMDB02111
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR r2082
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110037#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110037#

metaR LEUKTRE4t
kinetic law: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
name: leukotriene E4 transport
is: SBO:0000185
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r2128
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110037#
reversible: true

metaM 2dr1p c
is: CHEBI:58576
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
name: 2-Deoxy-D-ribose 1-phosphate
initial concentration: 1.0
is: C00672
initial amount: NaN
type: Species
is: HMDB01351

metaR GGH 7THFe
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7THF), extracellular
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#

metaM val L m
name: L-valine
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883
constant: false
boundary condition: false
type: Species
is: CHEBI:16414
initial concentration: 1.0
initial amount: NaN

metaM 3ohdcoa m
has only substance units: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false
constant: false
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
is: HMDB06402
type: Species
is: CHEBI:57349

metaR ATPtm
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: ADP/ATP transporter, mitochondrial
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
fast: false
modifier: MODEL1310110037#
reversible: false
product: MODEL1310110037#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_7fe08917_1205_4f1c_af0b_0878c97fb95f
name: CA14
is: SBO:0000252
is encoded by: hsa:23632
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: A8K3J4
type: Species
initial amount: NaN

metaR r2080
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110037#
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110037#

metaR r1636
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: true
product: MODEL1310110037#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaR r2081
product: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110037#

metaM malthx e
initial concentration: 1.0
is: C01936
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
name: Maltohexaose
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/5041
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r0683
reactant: MODEL1310110037#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000176
reversible: false
product: MODEL1310110037#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:

metaM ctp e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
boundary condition: false
type: Species
is: CHEBI:37563
is: SBO:0000247
constant: false
name: CTP(4-)

metaR DNDPt25m
modifier: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: dTDP transport via dCDP antiport
is: SBO:0000185
product: MODEL1310110037#
reversible: false
fast: false

metaR r2125
product: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110037#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
is: SBO:0000185

metaR GLYCLTDy
name: Glycolate dehydrogenase (NADP)
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.79
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:2689175 NOTES:JLR
modifier: MODEL1310110037#
reversible: false
is described by: ECO:0000269
fast: false
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_87eff7de_f349_41d8_a5c7_d8562baee7b4
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: _AI480132_1_c
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI480132
has only substance units: false

metaR r1637
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
type: Reaction

metaR FAOXC16080m
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM h2o e
initial concentration: 1.0
is: SBO:0000247
type: Species
name: H2O
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
is: CHEBI:15377
is: C00001
constant: false
boundary condition: false
has only substance units: false
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110037#_8b5894b2_15ee_4575_b577_38f7df075c56
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: O14732
is: SBO:0000252
is encoded by: hsa:3613
name: IMPA2
initial concentration: NaN
boundary condition: true

metaR PROSTGD2t
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110037#
name: prostaglandin transport via bicarbonate countertransport
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110037#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_53b86ff4_fc56_43c3_bea1_ccdf170129b0
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ALDH3B1
is encoded by: hsa:221
constant: false
has only substance units: false
is: P43353
type: Species

metaR r1106
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Postulated transport reaction
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#

metaM for e
is: CHEBI:15740
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
name: formate
is: HMDB00142

metaR r2126
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true

metaR RE0512M
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
fast: false
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
name: RE0512
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110037#_1796a901_a532_4152_ad88_220eae13c1e5
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23236
constant: false
type: Species
has only substance units: false
name: PLCB1
is: Q9NQ66
is: SBO:0000252

metaM HC01401 m
name: (S)-3-Hydroxydodecanoyl-CoA
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: SBO:0000247

metaR ABUTt2r
is described by: ECO:0000304
fast: false
reactant: MODEL1310110037#
type: Reaction
name: 4-aminobutyrate reversible transport in via proton symport
is: SBO:0000185
modifier: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
kinetic law: MODEL1310110037#
product: MODEL1310110037#

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_f3fadde4_e172_4f92_b18b_fc69d5df5099
is encoded by: hsa:115584
name: SLC5A11
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q8WWX8
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_546403a3_92d4_4534_9458_400ce0ce296b
is encoded by: hsa:2181
name: ACSL3
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: O95573
initial concentration: NaN
is: SBO:0000252

metaM nad m
is: HMDB00902
is: SBO:0000247
boundary condition: false
constant: false
is: C00003
is: CHEBI:57540
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_4664b38a_f075_415b_8a87_63f07d852511
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q7L2M7
constant: false
name: PFKL
is encoded by: hsa:5211
is: SBO:0000252
type: Species
initial amount: NaN

metaR r1779
product: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false

metaM prostge1 c
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01442
is: CHEBI:57397
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false
initial concentration: 1.0

metaM CE0785 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: cis,cis-myristo-5,8-dienoyl-CoA
is: CHEBI:57795

metaR r2123
kinetic law: MODEL1310110037#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true

metaR NADtpu
type: Reaction
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
name: NAD transporter, peroxisome

http://identifiers.org/biomodels.db/MODEL1310110037#_88c54175_5304_4904_81a2_2f13927a4f63
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8639
initial concentration: NaN
constant: false
name: AOC3
type: Species
boundary condition: true
is: Q16853
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_08bb5633_951f_40b6_99f5_4421f2050513
is encoded by: hsa:5313
boundary condition: true
type: Species
is: SBO:0000252
name: PKLR
constant: false
initial concentration: NaN
has only substance units: false
is: P30613
initial amount: NaN

metaR r1630
type: Reaction
reversible: true
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_fd05bcf6_fb24_4a16_b0c2_2a07cb9580bc
name: SLC17A1
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:6568
boundary condition: true
is: Q14916
is: SBO:0000252
has only substance units: false
constant: false

metaR r2087
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_04e7320e_db63_44c2_823a_eac96d6c59a5
is encoded by: hsa:NOS2A
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: _NOS2A_1_c
is: SBO:0000252
constant: false

metaM zymstnl r
has only substance units: false
initial amount: NaN
is: CHEBI:16608
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: HMDB06841
boundary condition: false
type: Species
constant: false
name: 5alpha-cholest-8-en-3beta-ol

http://identifiers.org/biomodels.db/MODEL1310110037#_955d15bd_a332_462f_be57_660d0ac95349
is: SBO:0000252
is: Q6UWQ5
is encoded by: hsa:84569
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
name: LYZL1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_11e5793a_48b1_452b_81b4_fc54a727cd82
type: Species
is: P22413
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5167
constant: false
name: ENPP1
is: SBO:0000252

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR ACNAMtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110037#
name: N-acetylneuraminate nuclear import
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
fast: false
reversible: false
reactant: MODEL1310110037#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_6d2de7ff_bc1c_45eb_a2c6_c6e69277b636
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: TXNRD1
initial concentration: NaN
is encoded by: hsa:7296
has only substance units: false

metaM cdp m
is: HMDB01546
boundary condition: false
is: SBO:0000247
type: Species
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
has only substance units: false
is: CHEBI:58069
initial concentration: 1.0
constant: false

metaR r2124
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM CE2417 m
has only substance units: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
type: Species
initial concentration: 1.0
is: HMDB11123
is: SBO:0000247
constant: false
is: CHEBI:28387
boundary condition: false

metaM gtp c
initial concentration: 1.0
is: CHEBI:37565
initial amount: NaN
name: GTP
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
is: HMDB01273
is: C00044
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

metaR r0680
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.137
reactant: MODEL1310110037#
reversible: true
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_66e86ff0_5270_4e61_94a8_a21e7aec57c5
name: ENPP3
is: Q308M7
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5169
boundary condition: true
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_e9704b69_e293_4155_bc30_a18d69df7e7d
is encoded by: hsa:220
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: ALDH1A3
boundary condition: true
is: P47895

metaR biomass reaction
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reversible: false
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
name: biomass_reaction
reactant: MODEL1310110037#

metaR r1631
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR UPPN
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110037#
name: b-ureidopropionase
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
modifier: MODEL1310110037#
fast: false
type: Reaction
product: MODEL1310110037#
reversible: false
is described by: ECO:0000269

metaR r2086
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110037#_713eb486_e145_4396_aa4f_70707064476d
is encoded by: hsa:2194
constant: false
is: SBO:0000252
is: P49327
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: FASN
boundary condition: true

metaR DCYTD
is described by: ECO:0000254
modifier: MODEL1310110037#
reversible: false
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
name: deoxycytidine deaminase
type: Reaction
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.5.4.5
is: SBO:0000176

metaR GLNt4
product: MODEL1310110037#
reversible: false
kinetic law: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
name: L-glutamine reversible transport via sodium symport
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
fast: false
modifier: MODEL1310110037#
reactant: MODEL1310110037#

metaM cdp n
name: CDP(3-)
boundary condition: false
is: CHEBI:58069
constant: false
has only substance units: false
is: HMDB01546
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaM prostge1 e
type: Species
initial amount: NaN
is: HMDB01442
is: CHEBI:57397
has only substance units: false
boundary condition: false
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM HC02205 c
name: prostaglandin-b2
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:28099
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
boundary condition: false
initial amount: NaN

metaM arab L e
name: L-arabinose
notes: FORMULA: C5H10O5 CHARGE: 0
type: Species
boundary condition: false
is: HMDB00646
has only substance units: false
initial amount: NaN
is: CHEBI:30849
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_ebf0d882_7ff6_477c_a347_a47eb27f6899
initial amount: NaN
type: Species
is: E5KSL6
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1716
is: SBO:0000252
constant: false
has only substance units: false
name: DGUOK

http://identifiers.org/biomodels.db/MODEL1310110037#_5c3d09b9_e64b_44f0_b287_c90004605bc9
is: SBO:0000252
constant: false
initial amount: NaN
name: SDHA
type: Species
is: P31040
is encoded by: hsa:6389
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR r2085
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
modifier: MODEL1310110037#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110037#

metaR r1632
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true

metaR NCNt
type: Reaction
is: SBO:0000185
reactant: MODEL1310110037#
modifier: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
fast: false
name: Na+/Ca2+-NH4+ exchange
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is described by: ECO:0000269

metaR XOL7AONEtr
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000185
name: lipid, flip-flop intracellular transport

metaR r2121
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
modifier: MODEL1310110037#

metaR TRPt
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000269
name: L-tryptophan transport
kinetic law: MODEL1310110037#
is: SBO:0000185
reversible: true
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
fast: false

metaR RE3000M
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
kinetic law: MODEL1310110037#
reversible: true
name: RE3000
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#

metaR GLYCLTtp
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: glycolate transport into peroxisome

metaR RE1254C
name: RE1254
kinetic law: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
reversible: true

metaM pmtcrn c
boundary condition: false
name: L-palmitoylcarnitine
is: CHEBI:17490
initial amount: NaN
type: Species
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247

metaM 34dhoxmand m
is: SBO:0000247
name: 3,4-Dihydroxymandelate
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:27637
boundary condition: false
is: HMDB01866
initial amount: NaN

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR ACACt2m
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
fast: false
reactant: MODEL1310110037#
modifier: MODEL1310110037#
name: Acetoacetate mitochondrial transport via H+ symport
type: Reaction
product: MODEL1310110037#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_1f833569_b75a_4388_b00e_d958178fd0fc
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: RBAK
is: Q9NYW8
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:57786

metaM msa m
name: 3-oxopropanoate
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
initial amount: NaN
is: HMDB11111
initial concentration: 1.0
has only substance units: false
is: CHEBI:33190

http://identifiers.org/biomodels.db/MODEL1310110037#_0877e052_efff_4d57_a0ea_2b89d4103a1a
initial concentration: NaN
is encoded by: hsa:2678
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: GGT1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_d7dbe3b6_0d91_4bf5_82bc_e17093b8c678
type: Species
is encoded by: hsa:3033
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q16836
name: HADH

metaM 56dthm c
initial amount: NaN
is: SBO:0000247
name: 5,6-dihydrothymine
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:27468
initial concentration: 1.0
is: HMDB00079
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_9941108b_6751_4bf7_8f38_85abc98e9a4c
is encoded by: hsa:197257
initial concentration: NaN
has only substance units: false
constant: false
name: LDHD
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR r0310
is: SBO:0000176
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
fast: false
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110037#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_0e9ea9fa_91c4_41e4_bc1e_db080a061567
is: SBO:0000252
constant: false
is: E9PB82
name: HSD17B4
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:3295
initial amount: NaN
has only substance units: false

metaM ddcacoa m
is: CHEBI:57375
is: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
is: HMDB03571
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
initial amount: NaN
has only substance units: false

metaR r2122
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110037#
fast: false
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185

metaR r0033
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reversible: false
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is: SBO:0000176

metaR r1633
fast: false
type: Reaction
reversible: true
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR EX glygn2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_233174ba_d4e7_4da5_95d1_b1e861e39677
initial amount: NaN
initial concentration: NaN
is: Q7LG56
name: RRM2B
type: Species
is: SBO:0000252
is encoded by: hsa:50484
constant: false
has only substance units: false
boundary condition: true

metaR r2084
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#

metaM 12ppd R c
is: HMDB01881
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: (R)-propane-1,2-diol
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:28972
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110037#_de763cb5_4aca_4326_ab52_1803cd91ba3e
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: Q7Z5T0
initial amount: NaN
name: SLC1A3
is encoded by: hsa:6507
initial concentration: NaN
constant: false

metaR GGT6
reactant: MODEL1310110037#
type: Reaction
name: Gamma-glutamyltransferase
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
fast: false

metaR r2357
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reversible: true

metaR r2196
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR r0464
reactant: MODEL1310110037#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
kinetic law: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
type: Reaction
fast: false

metaR r0311
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reversible: false
fast: false
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
modifier: MODEL1310110037#
type: Reaction
is described by: ECO:0000000

metaM arab L c
has only substance units: false
is: CHEBI:30849
name: L-arabinose
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
is: HMDB00646

metaM guln c
is: SBO:0000247
is: CHEBI:13115
has only substance units: false
is: HMDB03290
boundary condition: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
constant: false
initial concentration: 1.0
name: L-gulonate
type: Species
initial amount: NaN

metaM ade e
is: CHEBI:16708
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
is: HMDB00034
is: SBO:0000247
name: adenine
initial amount: NaN
constant: false
type: Species

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaR 4HGLSDm
product: MODEL1310110037#
is: SBO:0000176
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reactant: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110037#
reversible: true
modifier: MODEL1310110037#
type: Reaction

metaM HC02208 c
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
boundary condition: false
initial amount: NaN
name: prostaglandin-d1
is: CHEBI:27696
constant: false

metaR G6Pter
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110037#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_138cb6a1_16db_49c7_9343_4861fe8b95b2
name: _AI285872_1_c
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AI285872
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000212
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4

metaM tcynt e
name: thiocyanate
is: CHEBI:18022
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01453
type: Species
has only substance units: false

metaM h2o m
name: H2O
is: C00001
is: HMDB02111
initial amount: NaN
is: CHEBI:15377
type: Species
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

metaM dcsptn1crn c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
is: HMDB06321
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: docosa-4,7,10,13,16-pentaenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110037#_68853f9d_05e0_481e_aee1_3db69e1ece69
is: SBO:0000252
constant: false
name: ACSS1
initial concentration: NaN
is: Q9NUB1
is encoded by: hsa:84532
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaR MTHFCm
reversible: true
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000269
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110037#
type: Reaction

metaR r2120
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110037#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110037#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR r2195
is described by: ECO:0000000
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR r2358
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
name: Organic anion transporter 5 Utilized transport

metaM HC01409 m
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
name: Hexanoyl-CoA
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:27540
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

metaM HC01377 m
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: S-(3-Methylbutanoyl)-dihydrolipoamide
initial concentration: 1.0
is: CHEBI:27462
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_085d86c1_d5e1_47c9_b7ec_49dcca8efece
type: Species
initial amount: NaN
name: _AI091231_1_c
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI091231

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_e6aa2524_eec3_41cd_8165_ff700309b35e
name: RDH11
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51109
constant: false
initial amount: NaN
is: B4DDW0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_05d86c57_ff2a_43d1_b841_3ac6c269caf1
initial amount: NaN
is: Q99643
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:6391
name: SDHC
has only substance units: false
type: Species

metaM cgly e
is: HMDB00078
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
has only substance units: false
is: CHEBI:4047
name: L-cysteinylglycine
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR BILIRUBt2
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
fast: false
product: MODEL1310110037#
name: bilirubin transport via bicarbonate countertransport
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110037#

metaM udpglcur r
boundary condition: false
has only substance units: false
name: UDP-D-glucuronate
is: C00167
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:58052
is: HMDB00935
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167

metaR r1418
kinetic law: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
fast: false
reversible: true
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000176
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1

metaM h2o l
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
constant: false
is: CHEBI:15377
has only substance units: false
initial concentration: 1.0
name: water
initial amount: NaN
boundary condition: false
type: Species

metaM HC00319 m
name: Malonate
is: SBO:0000247
is: CHEBI:30794
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
constant: false
boundary condition: false

metaM malcoa r
is: HMDB01175
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57384
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial concentration: 1.0
name: malonyl-CoA(4-)

metaR r2355
reversible: true
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110037#

metaM ade c
constant: false
initial concentration: 1.0
is: CHEBI:16708
boundary condition: false
has only substance units: false
is: HMDB00034
is: C00147
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
name: Adenine
type: Species
initial amount: NaN

metaM pro D e
has only substance units: false
is: SBO:0000247
is: CHEBI:16313
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
initial amount: NaN
boundary condition: false
is: HMDB03411
name: D-proline
initial concentration: 1.0

metaR r1492
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
name: Utilized transport
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_57d0229c_2e30_44b5_8f5a_0822f7fa7967
initial concentration: NaN
has only substance units: false
name: PRDX1
constant: false
is: Q06830
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:5052
is: SBO:0000252

metaM tcynt c
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01453
is: CHEBI:18022
name: thiocyanate
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
boundary condition: false
is: SBO:0000247

metaM HC01115 c
type: Species
boundary condition: false
initial concentration: 1.0
name: NeuNGc
is: CHEBI:29025
has only substance units: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: SBO:0000247
constant: false
initial amount: NaN

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM HC02208 e
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin-d1
type: Species
is: CHEBI:27696
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false

metaR GLCMter
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
name: glucose transport via membrane vesicle
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

metaR RE1448N
reactant: MODEL1310110037#
name: RE1448
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
fast: false
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110037#

metaM Lkynr c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: L-kynurenine
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
has only substance units: false
is: CHEBI:16946
is: HMDB00684
constant: false
type: Species
initial amount: NaN

metaR r2193
reversible: true
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
product: MODEL1310110037#
type: Reaction

metaR r2356
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
reversible: true

metaR DM dgtp n
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgtp(n)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_db37f156_a80a_4644_840a_6bf1aa618e6e
type: Species
boundary condition: true
name: PPA2
is encoded by: hsa:27068
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r1993
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: false
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r1493
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
kinetic law: MODEL1310110037#
name: Utilized transport
type: Reaction
reversible: false
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_e495d886_6669_4924_a798_298126920166
type: Species
is encoded by: hsa:10935
is: P30048
initial concentration: NaN
constant: false
has only substance units: false
name: PRDX3
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_0db74d58_c20d_4449_a89b_79a22908172a
type: Species
name: HMGCS2
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:3158
is: SBO:0000252
is: P54868
has only substance units: false
initial concentration: NaN

metaM h2o n
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: water
type: Species
boundary condition: false
is: HMDB02111
is: SBO:0000247
constant: false

metaR PI45PLC
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110037#
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110037#
is: SBO:0000176
name: phosphatidylinositol 4,5-bisphosphate phospholipase C

metaM cgly c
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00078
constant: false
name: L-cysteinylglycine
is: CHEBI:4047
type: Species
boundary condition: false
initial amount: NaN

metaR RE2649M
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
reversible: true
fast: false
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110037#
name: RE2649
is: SBO:0000176
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_d42cc434_5514_48f6_842e_40488db5d32e
is encoded by: hsa:23007
has only substance units: false
name: PLCH1
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q4KWH8

metaR PA HStn
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: phosphatidate transport, nuclear
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

metaR r2353
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110037#
fast: false

metaR RE2660N
is described by: ECO:0000000
modifier: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
name: RE2660
type: Reaction
is: SBO:0000176

metaM lac L c
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00190
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate

metaR RE1845C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
name: RE1845
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
product: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
is: SBO:0000176
reactant: MODEL1310110037#

metaR HMGCOASim
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.3.10
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
modifier: MODEL1310110037#
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus

metaR r0688
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR OBDHc
reversible: false
product: MODEL1310110037#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
name: 2-Oxobutanoate dehydrogenase, cytosolic
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_b5be3c26_5b34_49fb_8f31_97b507ca0fd0
is: SBO:0000252
is: Q04760
boundary condition: true
initial amount: NaN
is encoded by: hsa:2739
constant: false
name: GLO1
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_8cd053e9_daa3_48a5_9cda_ffe3e93b3177
constant: false
is encoded by: hsa:1103
type: Species
has only substance units: false
is: SBO:0000252
name: CHAT
is: P28329
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM CE5121 m
initial concentration: 1.0
type: Species
boundary condition: false
name: trans-3-decenoyl-CoA
initial amount: NaN
is: CHEBI:57449
has only substance units: false
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
is: SBO:0000247

metaM 23cump e
boundary condition: false
has only substance units: false
name: 2',3'-cyclic UMP(1-)
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:60873
notes: FORMULA: C9H10N2O8P CHARGE: -1 INCHI: InChI=1S/C9H11N2O8P/c12-3-4-6-7(19-20(15,16)18-6)8(17-4)11-2-1-5(13)10-9(11)14/h1-2,4,6-8,12H,3H2,(H,15,16)(H,10,13,14)/p-1/t4-,6-,7-,8-/m1/s1 EHMN_ABBREVIATION: C02355
constant: false
initial amount: NaN

metaR r1571
reversible: true
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR GPIDAer
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
type: Reaction
reversible: false
reactant: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#

metaR r2354
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
reversible: true

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaM HC02214 c
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: CHEBI:28852
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: prostaglandin-f1alpha

http://identifiers.org/biomodels.db/MODEL1310110037#_2e85d010_8633_45ea_942e_4de7c35c07fe
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI694761
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: _AI694761_1_c

metaR PPItm
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
kinetic law: MODEL1310110037#
name: diphopshate transporter, mitochondrial
product: MODEL1310110037#
fast: false
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110037#_8141e5fd_daf7_4eeb_a000_16ea8bcf030e
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P31213
name: SRD5A2
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:6716
initial amount: NaN

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_a9763243_7208_4694_9d74_c0426a90af66
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:AI769281
name: _AI769281_1_e

metaR SERtN1
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
modifier: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000269
name: Serine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110037#_10372ebc_b480_4088_afb5_8c79b186dff2
name: SLC7A6
is: Q92536
constant: false
is encoded by: hsa:9057
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR r1570
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE1519M
product: MODEL1310110037#
name: RE1519
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaR 34HPPOR
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reversible: false
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.27

http://identifiers.org/biomodels.db/MODEL1310110037#_42b24f80_bb23_461b_b691_b2dcd3e797e1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P32321
type: Species
has only substance units: false
name: DCTD
is encoded by: hsa:1635
initial amount: NaN
constant: false

metaM lac L e
constant: false
name: (S)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
has only substance units: false
is: HMDB00190
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16651

metaM crm hs c
initial concentration: 1.0
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
name: N-acylsphingosine
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_5b5474f9_3d46_401f_b2e9_eee2dd359ae1
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:5281
is: Q6IB04
is: SBO:0000252
type: Species
name: PIGF
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_aaf6b665_6939_4f38_be28_90d6ce5babea
initial concentration: NaN
is: P22413
is encoded by: hsa:5167
initial amount: NaN
name: ENPP1
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM ribflv c
name: Riboflavin
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:3554
is: C00255
initial amount: NaN
constant: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: HMDB00244

metaR r1109
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
product: MODEL1310110037#
is described by: ECO:0000000
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6

metaR CYTK6n
name: cytidylate kinase (CMP,CTP),nuclear
fast: false
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM arachcoa m
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: HMDB04258
boundary condition: false
name: arachidyl coenzyme A
initial amount: NaN
is: CHEBI:15527
type: Species

metaR OCDCAtr
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_1c3d9a43_b21e_446c_a373_1de360defbe2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:217
initial amount: NaN
is: P05091
type: Species
name: ALDH2
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_023fb23d_1739_4f18_ae5b_f1045037a66a
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:6534
is: Q99884
has only substance units: false
name: SLC6A7

http://identifiers.org/biomodels.db/MODEL1310110037#_52de0852_d308_47ce_86ba_16851650b866
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR CREATt4 2 r
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000269
name: Creatine transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000185

metaR r0317
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110037#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:

metaR r2352
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110037#

metaR r0686
is: SBO:0000176
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_4fd34299_57a8_41bd_9dfd_94892b32cfe7
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q969N2
has only substance units: false
is encoded by: hsa:51604
initial amount: NaN
name: PIGT
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_3ab78fc2_f937_405e_be3c_db1e6eb67bc3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:60386
is: Q9HC21
constant: false
name: SLC25A19
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

metaM f1p c
name: D-Fructose 1-phosphate
type: Species
has only substance units: false
is: HMDB01076
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
constant: false
is: C01094
is: SBO:0000247
initial amount: NaN
is: CHEBI:18105
boundary condition: false

metaR BETALDHxm
name: betaine-aldehyde dehydrogenase, mitochondrial
fast: false
reactant: MODEL1310110037#
reversible: false
kinetic law: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110037#_fe09d3ec_a638_436e_8c83_34545cf7a014
type: Species
name: HADHA
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3030
is: E9KL44

metaM HC02214 e
is: CHEBI:28852
boundary condition: false
type: Species
has only substance units: false
name: prostaglandin-f1alpha
constant: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM hmgcoa m
is: SBO:0000247
is: CHEBI:15467
initial amount: NaN
constant: false
is: HMDB01375
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Hydroxymethylglutaryl-CoA
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaM CE5161 r
initial concentration: 1.0
is: HMDB00127
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:15748
initial amount: NaN
constant: false
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
is: SBO:0000247
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161

metaM nad x
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide
initial amount: NaN
constant: false
is: CHEBI:57540
is: C00003
is: SBO:0000247
type: Species
is: HMDB00902

metaM taur e
type: Species
is: C00245
constant: false
initial amount: NaN
is: SBO:0000247
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
is: CHEBI:3544
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR THRGLYexR
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-threonine/glycine reversible exchange

metaM o2 r
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:15379
boundary condition: false
initial concentration: 1.0
is: HMDB01377
initial amount: NaN
type: Species

metaR DOLMANP Uter
name: dolichol-phosphate mannose flippase (uterus)
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000

metaR r0483
product: MODEL1310110037#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reactant: MODEL1310110037#
fast: false
reversible: true

metaM pmtcrn x
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
is: HMDB00222
boundary condition: false
name: L-palmitoylcarnitine
type: Species
is: SBO:0000247
is: CHEBI:17490

metaM cdp c
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: CDP
is: CHEBI:58069
constant: false
initial concentration: 1.0
is: HMDB01546
boundary condition: false
is: C00112

metaM nac c
has only substance units: false
is: SBO:0000247
is: C00253
is: CHEBI:0
constant: false
type: Species
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0
boundary condition: false
is: HMDB01488
name: Nicotinate
initial amount: NaN

metaR r0246
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
reversible: false

metaM lald L c
initial amount: NaN
is: HMDB03052
constant: false
initial concentration: 1.0
is: SBO:0000247
name: (S)-lactaldehyde
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:18041
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaM 2obut c
is: CHEBI:16763
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
is: HMDB00005
is: C00109
has only substance units: false
name: 2-Oxobutanoate

metaM thf e
has only substance units: false
boundary condition: false
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57453
constant: false
is: SBO:0000247
type: Species
is: HMDB01846

metaM paf hs e
is: CHEBI:36707
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
type: Species

metaM glcur c
is: HMDB00127
type: Species
boundary condition: false
name: D-glucuronate
is: CHEBI:15748
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_f60c5ee7_1757_4e3f_8e99_485e4a52d510
is: O00142
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:7084
is: SBO:0000252
type: Species
name: TK2
initial concentration: NaN
initial amount: NaN

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_5df8e8aa_ea58_4911_a8e6_47aca32aa8e6
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:65010
is: Q9Y3Y1
constant: false
initial amount: NaN
name: SLC26A6
has only substance units: false

metaM utp e
has only substance units: false
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: UTP(4-)
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_e7df37d4_2e89_4c9e_b01c_f4d18e664ec4
is encoded by: hsa:1103
has only substance units: false
name: CHAT
constant: false
type: Species
is: D3DX95
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM gum e
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
name: gums
initial amount: NaN
is: http://identifiers.org/pubchem.compound/93131
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR PAFt
kinetic law: MODEL1310110037#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110037#
is: SBO:0000185
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
reversible: true
reactant: MODEL1310110037#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_5b6cbdde_83ea_445d_bc8e_3211cc650749
constant: false
has part: P07195
has only substance units: false
type: Species
initial amount: NaN
has part: P00338
is encoded by: hsa:3945
initial concentration: NaN
name: LDHA:LDHB
boundary condition: true
is encoded by: hsa:3939
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110037#_112d2078_43d6_4dc0_b767_7633fdf83e3b
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5279
name: PIGC

metaM fad c
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
is: HMDB01248
is: CHEBI:16238
is: SBO:0000247
is: C00016
has only substance units: false
type: Species
name: Flavin adenine dinucleotide oxidized
constant: false
initial concentration: 1.0

metaM lnlccoa r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
type: Species
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: linoleic coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110037#_749461cd_8615_4533_abbf_ee8e1dfeaeab
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:155184
name: SLC2A7
initial amount: NaN
has only substance units: false
is: Q6PXP3
initial concentration: NaN

metaR r0830
is described by: ECO:0000000
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_37123511_97ff_4c44_88ce_b28b42bd4beb
constant: false
name: PIGC
has only substance units: false
type: Species
is encoded by: hsa:5279
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q92535

metaM pap c
boundary condition: false
is: HMDB00061
type: Species
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:58343
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

http://identifiers.org/biomodels.db/MODEL1310110037#_15a13894_444b_4ece_a012_98dfc250df44
is: SBO:0000252
name: DGKQ
has only substance units: false
is: P52824
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:1609
constant: false
type: Species

metaM met L e
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
is: CHEBI:16643
is: HMDB00696
constant: false
has only substance units: false
is: SBO:0000247

metaR 3MOPt2im
reversible: false
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110037#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_749a96b8_6c3b_425a_b092_0ceaa72bed3c
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: SLC25A21
is: G3V4L5
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:89874

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM thbpt c
is: HMDB00027
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:15372
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: SBO:0000247
has only substance units: false
name: 5,6,7,8-tetrahydrobiopterin
type: Species
boundary condition: false

metaR r1551
reversible: true
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110037#_dcc30a01_a112_4dbb_b2f7_db85a50e7f00
initial amount: NaN
is: O95168
constant: false
boundary condition: true
is encoded by: hsa:4710
is: SBO:0000252
name: NDUFB4
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_5ecc9c09_d032_4e89_8199_27c6cc410e24
name: GUK1
initial concentration: NaN
is: Q16774
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:2987
initial amount: NaN
has only substance units: false

metaM xylt e
boundary condition: false
is: CHEBI:17151
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: HMDB02917
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: xylitol

metaM utp c
is: C00075
boundary condition: false
is: SBO:0000247
name: UTP
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
is: CHEBI:46398
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00285
type: Species

metaM glcur e
type: Species
constant: false
name: D-glucuronate
boundary condition: false
is: CHEBI:15748
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110037#_5dae7169_774e_4a25_bea6_31a5553182d1
initial concentration: NaN
is: SBO:0000252
is: Q8N695
constant: false
is encoded by: hsa:160728
has only substance units: false
name: SLC5A8
boundary condition: true
type: Species
initial amount: NaN

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_a02f7fa1_2d5a_4204_98a8_a607fba76b46
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2766
boundary condition: true
is: SBO:0000252
is: P36959
name: GMPR
has only substance units: false

metaM trdrd c
is: SBO:0000247
name: Reduced thioredoxin
type: Species
is: C00342
initial concentration: 1.0
is: CHEBI:15967
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

metaM thym c
initial amount: NaN
name: Thymine
is: SBO:0000247
is: HMDB00262
boundary condition: false
is: CHEBI:17821
has only substance units: false
constant: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
initial concentration: 1.0
is: C00178

metaM lac L x
type: Species
is: HMDB00190
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
boundary condition: false
name: (S)-lactate
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaM met L c
is: CHEBI:16643
constant: false
is: SBO:0000247
name: L-methionine
initial amount: NaN
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
initial concentration: 1.0
is: HMDB00696
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_9df85611_d8d0_49e5_9254_c460b3cca002
initial amount: NaN
name: SLC5A7
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: Q9GZV3
is encoded by: hsa:60482
constant: false
initial concentration: NaN

metaM HC00319 c
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
has only substance units: false
initial amount: NaN
is: CHEBI:30794

metaR DIDPtn
fast: false
name: dIDP nuclear transport
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r0480
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

metaR r1552
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110037#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_38666457_dc09_4d43_bfac_5dbb4ac8b629
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:NOS2A
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _NOS2A_1_e

metaM h2o r
type: Species
boundary condition: false
has only substance units: false
is: C00001
is: HMDB02111
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
constant: false
is: CHEBI:15377
name: H2O

metaM strdnc c
has only substance units: false
initial amount: NaN
type: Species
name: stearidonic acid C18:4, n-3
is: HMDB06547
constant: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205608
initial concentration: 1.0
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300

http://identifiers.org/biomodels.db/MODEL1310110037#_d7c99da9_5e8d_445d_bc51_76e6d004e8b3
is: SBO:0000252
boundary condition: true
is: P04183
has only substance units: false
initial concentration: NaN
name: TK1
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:7083

http://identifiers.org/biomodels.db/MODEL1310110037#_76ceaab1_042f_46f4_b429_d3d7c8a8a505
has only substance units: false
initial amount: NaN
is encoded by: hsa:65263
initial concentration: NaN
is: Q53H96
type: Species
name: PYCRL
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_e3c28680_cf20_4f07_958a_1e705cfd4258
name: _AA278423_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA278423
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaR D3AIBTm
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial

metaR r0885
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
modifier: MODEL1310110037#
product: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_c11f6ec1_8e17_4ac3_9cd4_4d6796675545
is encoded by: hsa:490
constant: false
type: Species
is: P20020
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ATP2B1

http://identifiers.org/biomodels.db/MODEL1310110037#_5c6c4c8b_e89f_4df3_8d7f_dfab96952e77
is encoded by: hsa:26289
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: AK5
boundary condition: true
initial concentration: NaN
constant: false

metaR PGS
is described by: ECO:0000269
kinetic law: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.99.1
fast: false
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
name: Prostaglandin G/H synthase

metaM glx x
has only substance units: false
initial concentration: 1.0
is: HMDB00119
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
is: CHEBI:36655
is: SBO:0000247

metaR r0242
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
type: Reaction
is described by: ECO:0000000
fast: false

metaR r1553
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaM cytd c
is: HMDB00089
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
is: CHEBI:17562
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
name: Cytidine
is: C00475

metaM cl c
is: CHEBI:3966
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
is: HMDB00492
constant: false
boundary condition: false
type: Species
name: Chloride
is: C00115
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM amet m
name: S-Adenosyl-L-methionine
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
boundary condition: false
is: C00019
initial amount: NaN
constant: false
type: Species
is: HMDB01185
initial concentration: 1.0
is: CHEBI:15414
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_568f33c2_a043_462b_b84c_8c9356b7071d
initial amount: NaN
boundary condition: true
is encoded by: hsa:112724
name: RDH13
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is: B3KVA3
has only substance units: false

metaR GLYBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
is: SBO:0000185
reactant: MODEL1310110037#

metaM 3hpp m
is: SBO:0000247
type: Species
is: HMDB00700
has only substance units: false
boundary condition: false
name: 3-hydroxypropionate
initial amount: NaN
is: CHEBI:16510
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013

metaR FAOXC2251836m
is: SBO:0000176
name: Beta oxidation of fatty acid
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110037#

metaR Htg
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110037#
name: proton diffusion (Golgi)
kinetic law: MODEL1310110037#
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_db1193b4_a6fc_49c0_b93b_aea37fbb6a4c
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AF116616
constant: false
type: Species
name: _AF116616_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM mercppyr c
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
name: 3-mercaptopyruvate
is: SBO:0000247
is: HMDB01368
initial concentration: 1.0
is: CHEBI:57678
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaM xylt c
is: CHEBI:17151
is: HMDB02917
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: xylitol

metaR RE1521M
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: RE1521
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reversible: true
modifier: MODEL1310110037#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110037#_e4ab9b35_0a2c_4136_a963_35b0cd88fd61
has only substance units: false
initial amount: NaN
is encoded by: hsa:23057
type: Species
name: NMNAT2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaR r0946
reactant: MODEL1310110037#
reversible: true
type: Reaction
product: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1554
reversible: true
fast: false
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
is: SBO:0000185

metaM ac m
constant: false
type: Species
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
initial amount: NaN
is: CHEBI:30089
is: SBO:0000247
boundary condition: false
name: acetate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_94e1ae0b_cd82_49e7_8bd9_47901fc4fe35
initial amount: NaN
has only substance units: false
name: COX8C
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: Q7Z4L0
is encoded by: hsa:341947
boundary condition: true

metaM C04849 e
is: CHEBI:57449
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
constant: false
initial amount: NaN
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_70000a50_0c2e_402f_8df4_84c0b83065e9
is encoded by: hsa:6539
initial concentration: NaN
type: Species
is: P48065
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC6A12

http://identifiers.org/biomodels.db/MODEL1310110037#_3d62dadf_effc_4bdc_b2f6_7cb236cc6cdc
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR PRODt2r
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
modifier: MODEL1310110037#
is: SBO:0000185
name: D-proline reversible transport via proton symport
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is described by: ECO:0000304
type: Reaction

metaM taur c
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00251
is: CHEBI:3544
is: SBO:0000247
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
constant: false
type: Species

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaR RPEc
product: MODEL1310110037#
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110037#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
is: SBO:0000176

metaR FALDH
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reversible: true
is described by: ECO:0000269
product: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
name: formaldehyde dehydrogenase
modifier: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110037#
fast: false

metaR 2HBO
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
kinetic law: MODEL1310110037#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
modifier: MODEL1310110037#

metaR r2338
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is: SBO:0000185
product: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaR r0834
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
type: Reaction
reversible: true
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000

metaM lnlccoa m
type: Species
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01064
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164

metaM Nacasp m
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
name: N-acetyl-L-aspartate(2-)
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00812
is: CHEBI:16953

metaR r0399
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
reversible: true
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
modifier: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000176

metaM nac e
is: C00253
boundary condition: false
is: HMDB01488
name: Nicotinate
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0
is: CHEBI:0

metaR ACHtn
fast: false
reversible: true
name: Acetylcholin transport, nuclear trhough pores
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM cl e
is: HMDB00492
constant: false
has only substance units: false
notes: FORMULA: Cl CHARGE: -1
type: Species
boundary condition: false
name: Chloride
is: C00115
initial amount: NaN
is: SBO:0000247
is: CHEBI:3966
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_a3dbea03_00cd_4e60_8426_f07c3750b62c
has only substance units: false
initial amount: NaN
boundary condition: true
name: _R33828_1_c
constant: false
is encoded by: hsa:R33828
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_03123dac_5677_40e8_a859_529e924028df
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110037#_8c2359d9_e551_47aa_a28a_2152d068afa6
initial amount: NaN
type: Species
has only substance units: false
name: CA7
boundary condition: true
constant: false
is encoded by: hsa:766
is: Q86YU0
initial concentration: NaN
is: SBO:0000252

metaR GGH 6DHFe
kinetic law: MODEL1310110037#
is: SBO:0000176
name: Gamma-glutamyl hydrolase (6DHF), extracellular
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_65abe77d_57bb_4197_bf77_c8effe69211a
name: _100128062_1_m
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:100128062
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaR FRDPtr
is: SBO:0000185
product: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110037#
reversible: true

metaM paf hs c
is: CHEBI:36707
type: Species
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0

metaR RETt
is: SBO:0000185
name: Retinol transport via faciliated diffusion
type: Reaction
kinetic law: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
product: MODEL1310110037#

metaM pristcoa x
initial concentration: 1.0
initial amount: NaN
name: pristanoyl coa
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
boundary condition: false
type: Species
is: CHEBI:51341
has only substance units: false
constant: false

metaM gln L e
type: Species
initial concentration: 1.0
name: L-glutamine
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
is: HMDB00641
has only substance units: false

metaR r1556
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
is: SBO:0000185

metaR r0245
fast: false
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110037#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
modifier: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR O2Stm
reversible: true
reactant: MODEL1310110037#
type: Reaction
name: superoxide anion transport via diffusion (mitochondria)
kinetic law: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110037#

metaR ALADGLYexR
product: MODEL1310110037#
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: D-alanine/glycine reversible exchange
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true

metaR GLCAASE8ly
fast: false
name: beta-glucuronidase, lysosomal
product: MODEL1310110037#
is described by: ECO:0000269
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
reactant: MODEL1310110037#

metaM dolmanp L c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Dolichyl phosphate D-mannose, human liver homolog
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:15809

metaR CLHCO3tex2
reactant: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
type: Reaction
fast: false
reversible: false
name: chloride transport via bicarbonate countertransport (2:1)
is described by: ECO:0000304
kinetic law: MODEL1310110037#

metaR PMANM
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.2
fast: false
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/5.4.2.8
is: SBO:0000176
name: phosphomannomutase
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_d26b0e98_4833_482f_b9b8_87724ec78f5a
constant: false
name: HAO2
is encoded by: hsa:51179
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_ea0aa8f9_d365_48c5_9ec9_86896f0e4319
constant: false
is: E2QRH8
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:5332
name: PLCB4
initial amount: NaN
initial concentration: NaN

metaR DURIPP
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: deoxyuridine phosphorylase
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.4.2.3

metaM akg c
has only substance units: false
name: 2-Oxoglutarate
is: CHEBI:16810
constant: false
is: C00026
is: SBO:0000247
boundary condition: false
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
type: Species
initial concentration: 1.0

metaR CYTK14n
type: Reaction
modifier: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110037#
fast: false
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
product: MODEL1310110037#

metaR ADRNCOAtx
kinetic law: MODEL1310110037#
fast: false
name: fatty acid intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
is: SBO:0000185
product: MODEL1310110037#

metaR SUCOASm
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
name: Succinate--CoA ligase (ADP-forming)
kinetic law: MODEL1310110037#
is: SBO:0000176
fast: false

metaM cyan c
constant: false
is: SBO:0000247
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: HMDB02084
boundary condition: false
is: CHEBI:18407

metaR RE3241R
reversible: false
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110037#
name: RE3241
fast: false
is: SBO:0000176
reactant: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction

metaR PGDI
is version of: http://identifiers.org/ec-code/2.5.1.18
name: Prostaglandin-H2 D-isomerase [Precursor]
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
reactant: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.2
reversible: true
product: MODEL1310110037#

metaR r0836
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110037#
is described by: ECO:0000000

metaR r1557
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_28e828cf_777d_45e1_ab00_6250e46cca3a
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5831
type: Species
initial concentration: NaN
has only substance units: false
is: P32322
name: PYCR1

metaR O2Stn
is: SBO:0000185
product: MODEL1310110037#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (nucleus)
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_125b6370_ba59_4ab2_af33_a721bc86a57f
is: P21953
has only substance units: false
initial concentration: NaN
name: BCKDHB
is: SBO:0000252
is encoded by: hsa:594
initial amount: NaN
constant: false
boundary condition: true
type: Species

metaR r0941
reversible: true
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
name: Free diffusion
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR GCC2bim
kinetic law: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2

metaM hista e
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: histamium
is: CHEBI:58432
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: HMDB00870

metaM HC10852 r
is: CHEBI:61540
initial amount: NaN
name: palmitoleyl-CoA(4-)
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_99c37a00_dc65_4986_9150_a69a90c3c32e
is: Q6FGQ4
constant: false
initial concentration: NaN
initial amount: NaN
name: PPT1
is encoded by: hsa:5538
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR r0549
is version of: http://identifiers.org/ec-code/6.1.1.17
modifier: MODEL1310110037#
is: SBO:0000176
reversible: true
product: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.6.5.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reactant: MODEL1310110037#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
kinetic law: MODEL1310110037#

metaM asp L m
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00191
name: L-aspartate(1-)
has only substance units: false
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: CHEBI:29991
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_5f7e2e8f_2b44_45f1_8f32_e5e2b68be2d3
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:4707
constant: false
name: NDUFB1
is: SBO:0000252
is: O75438

metaM his L c
initial concentration: 1.0
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
initial amount: NaN
is: CHEBI:15971
name: L-histidine
is: HMDB00177
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaM akg e
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
type: Species
name: 2-oxoglutarate(2-)
is: SBO:0000247
is: HMDB00208
is: CHEBI:16810

metaR r0193
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is: SBO:0000176
product: MODEL1310110037#
is described by: ECO:0000000
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

metaM ala D e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
boundary condition: false
type: Species
name: D-alanine
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01310
is: CHEBI:15570
is: SBO:0000247

metaM ctp m
name: CTP(4-)
type: Species
is: CHEBI:37563
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00082
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247

metaM thf m
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57453
has only substance units: false
is: HMDB01846
name: 5,6,7,8-Tetrahydrofolate
is: C00101

metaR ALAGLNexR
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
reversible: true
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_0655f467_c8f4_475e_a801_19cb0808e471
type: Species
name: ECI1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1632
initial amount: NaN
boundary condition: true
is: P42126
constant: false

metaR r0942
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
product: MODEL1310110037#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000000

metaM gln L c
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
constant: false
is: CHEBI:18050
boundary condition: false
name: L-glutamine
is: HMDB00641
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_c4f35c1a_1f71_4231_b632_83b5bb6fea42
name: _8781_1_c
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8781
type: Species

metaM ctp n
is: SBO:0000247
is: HMDB00082
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
constant: false
is: CHEBI:37563
boundary condition: false

metaM dolmanp L r
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:15809
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
has only substance units: false
initial concentration: 1.0
constant: false
name: Dolichyl phosphate D-mannose, human liver homolog
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_fd110be8_a204_4a8b_84df_b3a685f23236
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:55350
name: VNN3
boundary condition: true
type: Species

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM anth c
is: HMDB01123
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: CHEBI:16567
has only substance units: false
name: anthranilate
constant: false
initial amount: NaN
is: SBO:0000247

metaR r0196
product: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110037#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110037#
type: Reaction

metaM pmtcrn r
type: Species
name: L-palmitoylcarnitine
is: HMDB00222
boundary condition: false
is: CHEBI:17490
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
has only substance units: false

metaR PGI
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/5.3.1.9
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
product: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110037#
name: glucose-6-phosphate isomerase
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_1401861b_b1ef_44c3_9472_b78af53a8ed0
is encoded by: hsa:8867
type: Species
constant: false
has only substance units: false
boundary condition: true
is: C9JFZ1
is: SBO:0000252
name: SYNJ1
initial amount: NaN
initial concentration: NaN

metaR r0838
reactant: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
reversible: true
type: Reaction
product: MODEL1310110037#
name: Free diffusion
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.2.4

metaR RE1532M
kinetic law: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110037#
name: RE1532
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
product: MODEL1310110037#

metaR r1559
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
type: Reaction
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_f61d3bff_2d61_4934_8c38_aeb60decb3e3
is: A8K3L7
is: SBO:0000252
initial concentration: NaN
name: CDIPT
is encoded by: hsa:10423
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_fb2e153c_052b_4521_abca_d7e71477b846
boundary condition: true
type: Species
is encoded by: hsa:8525
initial concentration: NaN
initial amount: NaN
name: DGKZ
is: B7Z6M3
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_6199391b_e41d_4f2f_9128_51c4e98b6eed
type: Species
boundary condition: true
is encoded by: hsa:30833
has only substance units: false
is: Q8TCD5
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: NT5C

http://identifiers.org/biomodels.db/MODEL1310110037#_89f2c746_2ed0_4996_a9a3_604cd249ce8a
type: Species
is: P23219
initial concentration: NaN
is encoded by: hsa:5742
name: PTGS1
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_52495bd9_d9db_4d99_ac12_6eecf0a99279
has only substance units: false
boundary condition: true
is: O95169
initial amount: NaN
is: SBO:0000252
constant: false
name: NDUFB8
type: Species
is encoded by: hsa:4714
initial concentration: NaN

metaR RETFA
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
reversible: false
fast: false
kinetic law: MODEL1310110037#
type: Reaction
name: retinol acyltransferase

metaM malcoa c
name: Malonyl-CoA
initial amount: NaN
is: CHEBI:57384
is: C00083
initial concentration: 1.0
constant: false
is: HMDB01175
is: SBO:0000247
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_8ced315c_f8b9_4d9a_aba7_efa2f3dffe32
name: PNP
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4860
is: P00491
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM his L e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
has only substance units: false
is: HMDB00177
name: L-histidine
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_d221b92c_8e1e_4cfa_9780_4a46f44b021c
is: SBO:0000252
is: E9KL44
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:3030
initial concentration: NaN
name: HADHA
has only substance units: false

metaR TALA
name: transaldolase
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.2
is described by: ECO:0000000
modifier: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110037#
reversible: true
type: Reaction
is: SBO:0000176

metaR r2079
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110037#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR r0944
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reactant: MODEL1310110037#
name: Active transport
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#

metaM HC00361 c
name: sedoheptulose 1,7-bisphosphate(4-)
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:58335
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM ala D c
is: CHEBI:15570
boundary condition: false
is: SBO:0000247
name: D-alanine
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1

metaR r0839
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110037#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110037#
name: Postulated transport reaction
modifier: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_286838ae_5a79_481b_8270_2ee66790a364
is: P19440
is: SBO:0000252
constant: false
is encoded by: hsa:2678
initial concentration: NaN
initial amount: NaN
name: GGT1
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_e44da00d_2b46_458f_a61c_c3b985a4ad85
initial amount: NaN
is: SBO:0000252
name: ALDH1A3
boundary condition: true
is encoded by: hsa:220
initial concentration: NaN
constant: false
is: P47895
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_29c4caeb_255a_4e96_a0c8_9fb8455b6ebe
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5281
has part: Q6IB04
name: PIGF:PIGO
type: Species
is encoded by: hsa:84720
has only substance units: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110037#_b40163c3_cd8d_4a53_8981_640cb2603afe
initial concentration: NaN
name: SLC23A2
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: Q9UGH3
is encoded by: hsa:9962
is: SBO:0000252

metaM bamppald c
is: HMDB01106
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: beta-Aminopropion aldehyde
constant: false
is: http://identifiers.org/pubchem.compound/7975
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: C05665
is: SBO:0000247
initial amount: NaN

metaR GLUDym
product: MODEL1310110037#
name: glutamate dehydrogenase (NADP), mitochondrial
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is: SBO:0000176
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.4.1.3

http://identifiers.org/biomodels.db/MODEL1310110037#_af99fb58_2258_41ee_9896_29575228d127
initial amount: NaN
is: Q9BX95
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:81537
has only substance units: false
name: SGPP1
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_14cd7925_1c06_4ae8_91fc_d821c77460fd
name: SDHD
boundary condition: true
is: O14521
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6392

metaR ABUTD
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
name: Aminobutyraldehyde dehydrogenase
product: MODEL1310110037#
is described by: ECO:0000269
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_b2c2e377_c2c7_412c_9c7c_19be940180e6
boundary condition: true
constant: false
is: P15954
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1350
name: COX7C
initial concentration: NaN
type: Species

metaR RE3524R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
kinetic law: MODEL1310110037#
fast: false
name: RE3524
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000176
reversible: true
is described by: ECO:0000000

metaR r2021
is: SBO:0000185
product: MODEL1310110037#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR PGK
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000134
name: phosphoglycerate kinase
modifier: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.2.3
fast: false
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction

metaM strdnc l
type: Species
constant: false
is: C16300
name: stearidonic acid C18:4, n-3
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB06547
has only substance units: false

metaR DOPAt4 2 r
name: Dopamine reversible transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110037#
is: SBO:0000185
modifier: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#

metaM ditp c
is: SBO:0000247
is: CHEBI:61382
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species
has only substance units: false
initial amount: NaN
name: dITP(4-)
is: HMDB03537

metaM anth e
is: SBO:0000247
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
type: Species
is: HMDB01123
is: CHEBI:16567
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM dhf c
constant: false
is: C00415
name: 7,8-Dihydrofolate
is: HMDB01056
type: Species
initial concentration: 1.0
is: CHEBI:57451
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

http://identifiers.org/biomodels.db/MODEL1310110037#_93af8e94_49d2_4b2d_becb_425d6c06e6ee
constant: false
initial concentration: NaN
name: PANK3
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79646
type: Species
is: Q9H999
boundary condition: true

metaM cys L e
is: CHEBI:17561
constant: false
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
initial concentration: 1.0
type: Species
name: L-cysteine
initial amount: NaN
has only substance units: false
is: HMDB00574
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_0b25be30_0793_4e92_9023_b156609089ab
type: Species
has only substance units: false
name: CYP27A1
boundary condition: true
is: SBO:0000252
is: Q02318
constant: false
initial concentration: NaN
is encoded by: hsa:1593
initial amount: NaN

metaR PAIL HStn
reversible: true
reactant: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
name: phosphatidylinositol nuclear transport (diffusion)
type: Reaction

metaM dutp m
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
boundary condition: false
is: HMDB01191
is: CHEBI:17625
name: dUTP

metaM o2 m
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
boundary condition: false
initial amount: NaN
is: HMDB01377
is: CHEBI:15379
is: C00007
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM creat c
initial amount: NaN
constant: false
name: creatine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
is: CHEBI:16919
initial concentration: 1.0
is: HMDB00064
type: Species

metaR HISyLATthc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Histidine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR CITRtm
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: citrulline mitochondrial transport via proton antiport
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_f7edc018_2589_41fe_88e0_8f4e6124d65e
name: COX8A
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:1351
is: Q53XN1
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r1629
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_0a6db2b7_d057_45e0_943f_c54412a439d0
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P16885
is encoded by: hsa:5336
name: PLCG2
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaR FAOXC161802m
reversible: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110037#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaR NDPK2n
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
product: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear

metaM malttr e
name: maltotriose
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: CHEBI:27931
initial amount: NaN
initial concentration: 1.0
is: HMDB01262
has only substance units: false
is: C01835
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_5f42dd12_9615_4a13_95a9_615128ebc2ca
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: Q9NQU1
initial concentration: NaN
name: SLC26A6
is encoded by: hsa:65010
boundary condition: true

metaR r2129
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110037#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110037#
is: SBO:0000185

metaM ac e
is: CHEBI:30089
name: acetate
constant: false
has only substance units: false
type: Species
is: HMDB00042
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaM o2 n
name: dioxygen
is: HMDB01377
is: CHEBI:15379
constant: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false

metaM cmpacna n
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:57812
initial amount: NaN
is: HMDB01176
is: SBO:0000247
constant: false

metaM dutp n
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
is: HMDB01191
type: Species
name: dUTP
is: CHEBI:17625
initial amount: NaN

metaM spmd e
is: SBO:0000247
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
type: Species
is: C00315
is: HMDB01257
is: CHEBI:57834
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR r1628
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110037#_9416c60e_07e6_423c_9e10_cef9b780bb93
initial concentration: NaN
initial amount: NaN
is: P51687
name: SUOX
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6821
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_716350ac_65d1_438d_b4df_b1772d273782
initial amount: NaN
is encoded by: hsa:10948
is: SBO:0000252
has only substance units: false
is: B4DUY1
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: STARD3

http://identifiers.org/biomodels.db/MODEL1310110037#_054efaec_54a8_44ad_b14e_ca509b00b716
has only substance units: false
boundary condition: true
name: _R06874_1_r
is encoded by: hsa:R06874
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaR HMGLm
name: hydroxymethylglutaryl-CoA lyase
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.1.3.4
is described by: ECO:0000134
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
is: SBO:0000176
reversible: false

metaM cdp e
initial concentration: 1.0
name: CDP(3-)
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01546
boundary condition: false
is: CHEBI:58069
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_817c3551_f2b6_4786_90e3_fa204271e13d
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:386757
boundary condition: true
name: SLC6A10P
initial amount: NaN
type: Species

metaR r2023
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_737212f2_dfe0_413c_a229_500c4df5ef40
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC25A6
constant: false
is: Q6I9V5
is encoded by: hsa:293

metaM cyan e
has only substance units: false
is: HMDB02084
initial amount: NaN
constant: false
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false
is: CHEBI:18407
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM utp n
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
has only substance units: false
initial amount: NaN
is: CHEBI:46398
initial concentration: 1.0
is: HMDB00285
constant: false
boundary condition: false
is: SBO:0000247
type: Species

metaM h2o x
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
is: CHEBI:15377
is: HMDB02111
constant: false
initial concentration: 1.0
name: H2O
is: C00001
initial amount: NaN
has only substance units: false
type: Species

metaR r0730
modifier: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
reversible: false

metaM cys L c
boundary condition: false
is: CHEBI:17561
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
initial concentration: 1.0
name: L-cysteine
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00574
is: SBO:0000247

metaM hista c
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: histamium
type: Species
is: CHEBI:58432
is: SBO:0000247
constant: false
is: HMDB00870
initial amount: NaN

metaM dtmp e
has only substance units: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
name: dTMP(2-)
initial concentration: 1.0
is: CHEBI:26999
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01227

http://identifiers.org/biomodels.db/MODEL1310110037#_3ea60a13_cb17_428d_adde_0c29f9752c97
initial amount: NaN
name: RHAG
is: Q96E98
is encoded by: hsa:6005
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_ffe41e6d_92ca_4526_9c85_5cc2324a0796
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10050
type: Species
name: SLC17A4
is: Q9Y2C5

metaR r1627
is described by: ECO:0000000
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#

metaM pap g
is: CHEBI:58343
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
initial concentration: 1.0
constant: false

metaR r0774
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
product: MODEL1310110037#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
fast: false
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
modifier: MODEL1310110037#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_ac0ef94e_876c_4ea3_be26_3fff29f335a0
constant: false
is: Q9BZ23
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:80025
name: PANK2
boundary condition: true

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR r1851
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: Y+LAT2 Utilized transport
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110037#
reversible: false
fast: false

metaM ac c
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: SBO:0000247
initial concentration: 1.0
is: HMDB00042
has only substance units: false
initial amount: NaN
boundary condition: false
name: acetate
constant: false
type: Species

metaM creat e
initial amount: NaN
is: CHEBI:16919
is: SBO:0000247
is: HMDB00064
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false
name: creatine
initial concentration: 1.0
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_c97cf7ca_2078_47e9_b9a2_07dd1823f56f
type: Species
boundary condition: true
is: P28330
has only substance units: false
is: SBO:0000252
name: ACADL
constant: false
initial concentration: NaN
is encoded by: hsa:33
initial amount: NaN

metaM Nacasp c
is: SBO:0000247
constant: false
name: N-acetyl-L-aspartate(2-)
is: CHEBI:16953
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: HMDB00812
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_8b4575d3_2d59_4203_bd73_1959082ecd79
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:55163
is: Q9NVS9
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: PNPO

http://identifiers.org/biomodels.db/MODEL1310110037#_19f1c6e9_59a2_4896_b89a_ddd0bb9ed4cf
initial amount: NaN
type: Species
has only substance units: false
name: DEGS1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8560
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_2d0e0d9f_c379_4522_b417_ee0d89477c86
type: Species
initial concentration: NaN
initial amount: NaN
name: CA13
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: Q8N1Q1
is encoded by: hsa:377677

metaM cytd m
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00089
has only substance units: false
name: cytidine
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475

metaM spmd c
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57834
is: C00315
is: HMDB01257
initial concentration: 1.0
constant: false
initial amount: NaN
name: Spermidine

metaR r0940
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_5dae3b29_87a1_43a3_9ce7_e1905786fd78
constant: false
name: _AA502753_1_m
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA502753

metaR r1626
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false

metaR MERCPLACCYSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
product: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
name: 3-mercaptolactate-cysteine disulfide transport, extracellular

http://identifiers.org/biomodels.db/MODEL1310110037#_471a0872_1b09_4e2c_b3bf_e9c68a2c80c5
boundary condition: true
constant: false
is: P07451
is: SBO:0000252
is encoded by: hsa:761
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: CA3

metaR GULN3D
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
name: L-gulonate 3-dehydrogenase
fast: false
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_2a6bd504_22f4_4c2a_86b2_71a817c6bdac
initial amount: NaN
type: Species
is encoded by: hsa:2348
name: FOLR1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaR r1624
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
reversible: true
product: MODEL1310110037#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaM odecoa r
initial concentration: 1.0
constant: false
name: oleoyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:57387
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
is: HMDB01322

http://identifiers.org/biomodels.db/MODEL1310110037#_8648052c_7766_4c4d_9d32_a3ede28a89b7
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NDUFA8
is encoded by: hsa:4702
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: B1AM93

metaM glx m
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: glyoxylate
initial amount: NaN
is: SBO:0000247
is: HMDB00119
is: CHEBI:36655
constant: false

metaR PUNP3
product: MODEL1310110037#
reversible: true
fast: false
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: purine-nucleoside phosphorylase (Guanosine)
kinetic law: MODEL1310110037#

metaR r2137
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110037#
is described by: ECO:0000000

metaR r0731
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false

metaR MTHFD
is: SBO:0000176
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
product: MODEL1310110037#
is described by: ECO:0000134
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP)
type: Reaction
modifier: MODEL1310110037#

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR FAOXC140
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110037#

metaR r1625
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#

metaR SPODMe
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110037#
reversible: false
type: Reaction
product: MODEL1310110037#
name: superoxide dismutase, extracellular
reactant: MODEL1310110037#
is: SBO:0000176
fast: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110037#_221127b7_b43d_4c70_b25a_4ec6b378e7c2
is: SBO:0000252
name: BDH1
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: Q02338
is encoded by: hsa:622
initial concentration: NaN

metaM mercplac c
type: Species
is: http://identifiers.org/pubchem.compound/8118
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
name: 3-Mercaptolactate
is: SBO:0000247
is: HMDB02127
is: C05823
initial amount: NaN
constant: false

metaR Htr
product: MODEL1310110037#
fast: false
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
name: H transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
is: SBO:0000185

metaM oxa c
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: CHEBI:30623
is: HMDB02329
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_5584ea7c_d480_4efc_a984_f3eb16c6098e
name: GGT2
boundary condition: true
is: SBO:0000252
is encoded by: hsa:728441
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR PECGCHLe
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_90467d90_e81a_4855_81a8_8f9d47708bdd
initial concentration: NaN
boundary condition: true
is encoded by: hsa:211
name: ALAS1
initial amount: NaN
type: Species
is: Q5JAM2
constant: false
is: SBO:0000252
has only substance units: false

metaR SERDGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000304
fast: false
product: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
type: Reaction
name: D-Serine/Glutamine reversible exchange
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR PUNP2
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Deoxyadenosine)
reversible: true
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false
is: SBO:0000176

metaR r0541
reactant: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
kinetic law: MODEL1310110037#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_9e680593_668d_4190_9af5_21a0a9e1623b
constant: false
is: SBO:0000252
is encoded by: hsa:2678
is: P19440
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GGT1
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_dd96f8a5_f682_4503_a49a_df0220b4b15a
name: ST20
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:400410
is: Q9HBF5

metaR R group phosphotase 3
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110037#
name: R group phosphotase 3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000000

metaR r0732
fast: false
reversible: false
product: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176

metaR MTHFC
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110037#
type: Reaction
name: methenyltetrahydrofolate cyclohydrolase
is: SBO:0000176
is described by: ECO:0000134

metaR CYTK7n
modifier: MODEL1310110037#
type: Reaction
is: SBO:0000176
name: cytidylate kinase (CMP,UTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110037#
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110037#_9702bbd3_f12c_4f5f_bcc1_0ee9ccfa65bb
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: GMPPA
is: Q96IJ6
is encoded by: hsa:29926

metaM HC00229 e
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: Isomaltose
is: CHEBI:28189
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_d3de6861_5766_4464_896d_4f60090f888c
is: Q5JPA4
is encoded by: hsa:53919
type: Species
has only substance units: false
boundary condition: true
constant: false
name: SLCO1C1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR LEUPHELAT2tc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM gdpmann c
type: Species
is: CHEBI:57527
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
has only substance units: false
initial concentration: 1.0
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01163
constant: false

metaM 10fthf m
boundary condition: false
type: Species
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00972

http://identifiers.org/biomodels.db/MODEL1310110037#_b8db0eb0_abeb_4d60_bb1c_e9c3449408b8
initial concentration: NaN
is: P24310
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:1346
constant: false
name: COX7A1
type: Species

metaM arachdcoa x
initial concentration: 1.0
is: SBO:0000247
is: HMDB06523
boundary condition: false
type: Species
is: CHEBI:57368
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
name: arachidonoyl-CoA(4-)

metaR PUNP5
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
reactant: MODEL1310110037#
type: Reaction
fast: false
kinetic law: MODEL1310110037#
name: purine-nucleoside phosphorylase (Inosine)
reversible: true
is described by: ECO:0000269

metaR r0733
is: SBO:0000176
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110037#

metaR PTCRTD
fast: false
name: diffusion of putriscine into the endothelial cells
is: SBO:0000185
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.

http://identifiers.org/biomodels.db/MODEL1310110037#_19d9cd74_2039_4924_8a6e_9882267cfe4a
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: _AV717590_1_c
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AV717590

metaR PPDOy
type: Reaction
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
reversible: false
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110037#
is described by: ECO:0000269
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false

metaR RE1518M
is described by: ECO:0000000
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
kinetic law: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
name: RE1518
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110037#
is: SBO:0000176

metaR r2139
is: SBO:0000185
reversible: true
reactant: MODEL1310110037#
fast: false
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_32f83bd4_59a2_47ac_bb88_9d38af90f8b9
has only substance units: false
initial amount: NaN
is encoded by: hsa:2729
is: SBO:0000297
constant: false
initial concentration: NaN
is encoded by: hsa:2730
boundary condition: true
has part: P48507
name: GCLC:GCLM
type: Species
has part: E1CEI4

metaM lpam m
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: HMDB00962
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17460
name: lipoamide
is: SBO:0000247
boundary condition: false
type: Species

metaM HC01602 c
name: 10-formyltetrahydrofolate-[Glu](5)
is: HMDB00067
is: SBO:0000247
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaR r1299
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110037#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
type: Reaction
name: Vesicular transport
product: MODEL1310110037#

metaR r1622
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true

metaR URIK1
reversible: false
reactant: MODEL1310110037#
is: SBO:0000176
name: uridine kinase (ATP:Uridine)
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.48
modifier: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR R group phosphotase 2
product: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 2
reversible: false
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#

metaM xol7ah2al c
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
is: CHEBI:27428
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR RE3520E
product: MODEL1310110037#
name: RE3520
is version of: http://identifiers.org/ec-code/1.11.1.9
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
kinetic law: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_b8a2bbf7_2948_4ea4_9eca_6e41eeeaaf80
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:4695
name: NDUFA2
boundary condition: true
initial amount: NaN
is: O43678
has only substance units: false

metaM 10fthf l
is: CHEBI:57454
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00972
name: 10-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
constant: false
boundary condition: false

metaR r0734
reactant: MODEL1310110037#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110037#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110037#
type: Reaction

metaR PUNP4
name: purine-nucleoside phosphorylase (Deoxyguanosine)
reversible: true
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110037#
is described by: ECO:0000269
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
type: Reaction
product: MODEL1310110037#

metaR PPDOx
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000269
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
fast: false
modifier: MODEL1310110037#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_5c702cb9_b5c6_4d82_a3cc_3da263374db9
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: CA4
type: Species
has only substance units: false
is: Q6FHI7
is encoded by: hsa:762
is: SBO:0000252

metaM dhf e
has only substance units: false
is: HMDB01056
initial amount: NaN
is: SBO:0000247
is: CHEBI:57451
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
boundary condition: false
name: dihydrofolate(2-)
type: Species
initial concentration: 1.0

metaM dchac e
constant: false
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1
type: Species
initial concentration: 1.0
name: deoxycholic acid
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00626

http://identifiers.org/biomodels.db/MODEL1310110037#_1bd76f5d_e073_4ef0_a5c3_90fadadf8740
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:54363
name: HAO1
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9UJM8

metaR O2Stx
name: superoxide anion transport via diffusion (peroxisome)
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR R group phosphotase 1
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
name: R group phosphotase 1
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000176
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#

metaR r1298
name: Vesicular transport
is described by: ECO:0000000
product: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
fast: false
type: Reaction

metaM 3odcoa m
type: Species
constant: false
initial concentration: 1.0
is: HMDB03939
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: SBO:0000247
name: 3-Oxodecanoyl-CoA
is: CHEBI:28528

metaR r1623
modifier: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR r0735
is: SBO:0000176
product: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

http://identifiers.org/biomodels.db/MODEL1310110037#_3634e6cd_9a1c_432d_a0cb_e8a2c743a5d5
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:275
is: P48728
name: AMT
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaR PUNP7
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
product: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110037#
is described by: ECO:0000269
kinetic law: MODEL1310110037#
reversible: true
name: purine-nucleoside phosphorylase (Xanthosine)

http://identifiers.org/biomodels.db/MODEL1310110037#_d5371cee_0a7b_4537_ab65_04c29ce0539a
is encoded by: hsa:1103
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q6LEN5
name: CHAT

metaM CE2420 m
is: SBO:0000247
is: HMDB11123
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
has only substance units: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
initial amount: NaN
is: CHEBI:28387
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR THFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110037#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110037#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110037#_ce013fd0_760a_4936_80bc_ebb731176b42
is encoded by: hsa:H77542
initial concentration: NaN
initial amount: NaN
constant: false
name: _H77542_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_2d2fd3a2_8451_4e7c_ab0c_f42850b70c6b
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: GLUL
is: SBO:0000252
is encoded by: hsa:2752
is: P15104
type: Species

metaM dcdp c
is: HMDB01245
is: CHEBI:58593
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: dCDP
is: C00705
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r0779
fast: false
modifier: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM HC02213 e
type: Species
initial concentration: 1.0
boundary condition: false
name: prostaglandin-e3
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: CHEBI:28031
has only substance units: false

metaR r1620
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110037#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_7d8c6ebb_6a37_4fbd_b295_bdda60364a21
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:314
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: AOC2
type: Species

metaR Htx
name: H transporter, peroxisome
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
reversible: true
type: Reaction

metaM odecoa m
constant: false
is: HMDB01322
is: SBO:0000247
initial concentration: 1.0
name: Octadecenoyl-CoA (n-C18:1CoA)
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57387
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false

metaM abt e
is: HMDB01851
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
boundary condition: false
has only substance units: false
constant: false
name: L-arabinitol
initial concentration: 1.0
is: CHEBI:18403
initial amount: NaN
type: Species
is: SBO:0000247

metaR r0321
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.2
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reversible: false
modifier: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
type: Reaction

metaR r2133
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR PUNP6
reactant: MODEL1310110037#
reversible: true
fast: false
name: purine-nucleoside phosphorylase (Deoxyinosine)
is described by: ECO:0000269
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
type: Reaction
modifier: MODEL1310110037#
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_2d233c49_5a8c_4a35_905e_3c289f4fb2dd
constant: false
name: DGKG
is: P49619
has only substance units: false
is encoded by: hsa:1608
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_beb4ec14_3d59_4ee3_80a7_7dd26b94b818
type: Species
boundary condition: true
is: Q59EA4
name: PLD1
is encoded by: hsa:5337
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR SBTR
reversible: false
name: D-sorbitol reductase
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110037#
is described by: ECO:0000269

metaM o2 e
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: C00007
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15379
is: HMDB01377
type: Species
has only substance units: false
name: O2

http://identifiers.org/biomodels.db/MODEL1310110037#_33ff3711_f71a_4144_8133_c40e9ba5a7eb
is: Q16775
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:3029
is: SBO:0000252
name: HAGH
constant: false

metaR RE1709C
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000176
name: RE1709

metaR r1621
reactant: MODEL1310110037#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#

metaR FRDPtc
type: Reaction
name: lipid, flip-flop intracellular transport
is: SBO:0000185
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ

metaR DGTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
fast: false
is described by: ECO:0000000
name: dGTP diffusion in nucleus
reversible: true
reactant: MODEL1310110037#
is: SBO:0000185

metaR r0545
reactant: MODEL1310110037#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is: SBO:0000176
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_a8fc64de_fc7d_4ed7_a725_fe3b3d7deab6
is: B4DNK4
initial concentration: NaN
type: Species
has only substance units: false
name: PKM2
initial amount: NaN
is encoded by: hsa:5315
is: SBO:0000252
boundary condition: true
constant: false

metaR MCCCrm
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
is described by: ECO:0000269
fast: false
is: SBO:0000176
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
name: methylcrotonoyl-CoA carboxylase, mitochondrial
reversible: true
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.4.1.4
type: Reaction

metaR ALDD2xm
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
reversible: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false
type: Reaction
reactant: MODEL1310110037#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_a2080308_28f3_4a81_b16f_e8524e1158cc
has only substance units: false
is: SBO:0000252
boundary condition: true
is: P11498
name: PC
constant: false
initial concentration: NaN
is encoded by: hsa:5091
initial amount: NaN
type: Species

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR LYSOXp
name: L-lysine oxidase, peroxisomal
kinetic law: MODEL1310110037#
type: Reaction
reversible: false
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110037#_daf2ea91_8ba2_4603_8fb8_07ff2a2f7971
is encoded by: hsa:5313
name: PKLR
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is: P30613
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR RE1447N
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
product: MODEL1310110037#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
fast: false
name: RE1447

metaM HC02213 c
boundary condition: false
type: Species
name: prostaglandin-e3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:28031
has only substance units: false
initial concentration: 1.0

metaR PMTCOAtx
product: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110037#
fast: false
type: Reaction

metaR 5ADTSTSTERONEte
type: Reaction
fast: false
kinetic law: MODEL1310110037#
reversible: true
name: 5 alpha dihydrotesterone transport
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_15e2db0b_ace6_46f2_b7f5_30138df9319b
is encoded by: hsa:AI935189
is: SBO:0000252
initial concentration: NaN
name: _AI935189_1_m
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_5280ca67_ddd0_4112_9c11_f68115f660f0
initial amount: NaN
has only substance units: false
is encoded by: hsa:6514
name: SLC2A2
constant: false
boundary condition: true
is: P11168
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_70a9e739_0a03_4d05_a8e7_6f7692ed8cec
is encoded by: hsa:51268
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: Q9P0Z9
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PIPOX

metaM abt c
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: L-arabinitol
constant: false
is: CHEBI:18403

http://identifiers.org/biomodels.db/MODEL1310110037#_dcfb2f8c_8bd1_4c28_9bc3_8c11c5496deb
name: NDUFAB1
is: SBO:0000252
is: O14561
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4706

metaM 4hpro LT m
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: trans-4-hydroxy-L-proline
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: SBO:0000247
is: CHEBI:18095
is: HMDB00725
has only substance units: false
initial concentration: 1.0

metaM fad m
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
initial amount: NaN
is: C00016
has only substance units: false
type: Species
boundary condition: false
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: CHEBI:16238
constant: false

metaR r0547
is: SBO:0000176
reversible: true
product: MODEL1310110037#
fast: false
type: Reaction
is described by: ECO:0000000
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.17.1.4
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#

metaM o2 c
constant: false
has only substance units: false
is: CHEBI:15379
is: SBO:0000247
boundary condition: false
type: Species
name: O2
initial amount: NaN
is: HMDB01377
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007

metaR ASPTA
reactant: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
name: aspartate transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction

metaM cmpacna c
type: Species
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
is: SBO:0000247
is: CHEBI:57812
initial concentration: 1.0
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_2278e25c_9887_4507_8cd4_af9a6fc3134d
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:FLJ44968
initial concentration: NaN
name: _FLJ44968_1_m

metaR MACACI
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.18
modifier: MODEL1310110037#
name: maleylacetoacetate isomerase
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_2f322e6a_af01_4cc5_8697_0693e59afd4c
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: ALDH3A1
is encoded by: hsa:218
is: P30838

metaR RE3001M
kinetic law: MODEL1310110037#
name: RE3001
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.34
reactant: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reversible: true

metaR ASPte
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000185
name: diffusion of aspartate into blood
product: MODEL1310110037#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
fast: false
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_2c216d55_0ce8_4d43_b38f_6e1c77e42d09
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _AA854479_1_m
is encoded by: hsa:AA854479
type: Species
boundary condition: true
constant: false

metaM 2obut m
is: HMDB00005
initial concentration: 1.0
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 2-oxobutanoate
is: CHEBI:16763

metaR r2136
reversible: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110037#
reactant: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_03d8a5e7_86ca_4eaf_af72_6a114ad5aa25
constant: false
initial amount: NaN
is: O43570
type: Species
is encoded by: hsa:771
boundary condition: true
has only substance units: false
initial concentration: NaN
name: CA12
is: SBO:0000252

metaR SRTNtu
reversible: true
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110037#
is: SBO:0000185
name: Serotonin uniport
product: MODEL1310110037#
modifier: MODEL1310110037#

metaM ethamp r
name: O-phosphonatoethanaminium(1-)
initial concentration: 1.0
is: CHEBI:58190
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00224
type: Species

metaR RDH1
type: Reaction
kinetic law: MODEL1310110037#
name: retinol dehydrogenase (all-trans)
modifier: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
reactant: MODEL1310110037#
is: SBO:0000176
reversible: true
fast: false

metaR MMTSADm
reactant: MODEL1310110037#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
type: Reaction
product: MODEL1310110037#
reversible: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human

metaR TREHe
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.2.1.28
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
product: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
is described by: ECO:0000269
type: Reaction
name: alpha,alpha-trehalase

http://identifiers.org/biomodels.db/MODEL1310110037#_1a68241a_a763_4d7a_b283_c4ae0b8b0031
name: SLC3A1
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:6519
is: SBO:0000252
boundary condition: true
is: Q07837

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM ascb L c
boundary condition: false
is: HMDB00044
name: L-ascorbate
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
constant: false
is: CHEBI:38290
has only substance units: false

metaM fum m
is: HMDB00134
boundary condition: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate
initial concentration: 1.0
is: C00122
is: CHEBI:29806
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247

metaM 4fumacac c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18034
name: 4-fumarylacetoacetate(2-)
constant: false
is: HMDB01268
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
boundary condition: false

metaM 1p3h5c m
is: HMDB01369
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial concentration: 1.0
is: CHEBI:6151
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_361a9fd9_52b4_4785_be36_1e7b873e7630
constant: false
name: PLCB4
is: SBO:0000252
is encoded by: hsa:5332
initial amount: NaN
boundary condition: true
type: Species
is: Q15147
has only substance units: false
initial concentration: NaN

metaR SPODMn
name: superoxide dismutase, nuclear
is version of: http://identifiers.org/ec-code/1.15.1.1
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000269

metaR 3HKYNAKGAT
modifier: MODEL1310110037#
fast: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
reactant: MODEL1310110037#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110037#
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.64
is version of: http://identifiers.org/ec-code/2.6.1.7

metaR DGK1
modifier: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110037#
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110037#
reversible: true
name: deoxyguanylate kinase (dGMP:ATP)
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.8

metaM Rtotal3 c
name: R total 3 position
initial amount: NaN
type: Species
is: HMDB01448
is: CHEBI:16189
notes: FORMULA: CO2FULLR3 CHARGE: -1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_4b030986_d0c0_4155_9ba2_7002cd4cb783
constant: false
is: SBO:0000252
is encoded by: hsa:222
name: ALDH3B2
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P48448

metaR r2130
reactant: MODEL1310110037#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110037#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#

metaR BUTt2r
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#
name: Butyrate transport via proton symport, reversible
modifier: MODEL1310110037#
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000185

metaR DHCRD1
fast: false
name: dihydroceramide desaturase
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
reversible: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_90fb2c07_1661_41e1_a9b4_d5af5f338cdd
is: O43708
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:2954
name: GSTZ1
type: Species
boundary condition: true

metaR MTHFDm
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
fast: false
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD

metaR r2344
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#

metaR CTPtn
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110037#
product: MODEL1310110037#
fast: false
name: CTP diffusion in nucleus

metaR RE1447M
name: RE1447
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR SPODMm
modifier: MODEL1310110037#
is: SBO:0000176
fast: false
product: MODEL1310110037#
name: superoxide dismutase
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction

metaR r1291
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Postulated transport reaction
fast: false
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true

metaR CITtam
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
reversible: true
name: citrate transport, mitochondrial
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_ff126df8_6dcf_4f5f_b0d0_f0f4b036c215
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:T83654
type: Species
name: _T83654_1_m
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM ascb L e
is: SBO:0000247
is: HMDB00044
boundary condition: false
initial amount: NaN
name: L-ascorbate
has only substance units: false
is: CHEBI:38290
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0
constant: false
type: Species

metaR r2131
modifier: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000000

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR ADSS
is version of: http://identifiers.org/ec-code/6.3.4.4
product: MODEL1310110037#
reversible: false
name: adenylosuccinate synthase
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_8152ac49_bc99_4b96_9c8a_5d0c66c91220
has only substance units: false
is: SBO:0000252
name: CA5B
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:11238
is: Q9Y2D0
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_0b013932_002c_4a4e_bb94_f4ad23c41759
initial concentration: NaN
is: P54868
is encoded by: hsa:3158
initial amount: NaN
is: SBO:0000252
constant: false
name: HMGCS2
type: Species
has only substance units: false
boundary condition: true

metaM dhf m
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: CHEBI:57451
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: dihydrofolate(2-)
is: HMDB01056

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_ca729bfd_44e5_45bc_a53b_33e6ddab1e63
type: Species
is: SBO:0000252
is: P32320
name: CDA
is encoded by: hsa:978
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_03896fcf_6bba_4a76_926a_9d0c01525661
is encoded by: hsa:52
is: Q59EH3
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: ACP1
is: SBO:0000252

metaR RE1709N
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
is: SBO:0000176
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
modifier: MODEL1310110037#
reversible: true
name: RE1709
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000

metaR PI4PP
reversible: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110037#
name: phosphatidylinositol-4-phosphate 4-phosphatase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD

metaR DASCBR
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110037#
name: dehydroascorbate reductase
is version of: http://identifiers.org/ec-code/1.8.4.1
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
fast: false
is: SBO:0000176

metaM Rtotal3 e
is: SBO:0000247
has only substance units: false
is: C00255
constant: false
boundary condition: false
is: CHEBI:3554
notes: FORMULA: CO2FULLR3 CHARGE: -1
type: Species
is: HMDB00244
name: R total 3 position
initial amount: NaN
initial concentration: 1.0

metaR r2346
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r2132
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110037#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_f8a0ef8b_60fc_4ec7_91c3_5eefa1a2dca3
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: _AI222095_1_m
is encoded by: hsa:AI222095
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_054af8ed_13fc_4817_81a6_fe9d9e1f3ffa
is: Q16773
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: CCBL1
boundary condition: true
is encoded by: hsa:883

metaR PAPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
name: adenosine 3',5'-bisphosphate Golgi transport
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
reversible: false

metaR FRUt4
product: MODEL1310110037#
name: D-fructose transport via sodium cotransport
is described by: ECO:0000269
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#

metaM glcur l
type: Species
is: CHEBI:15748
initial concentration: 1.0
name: D-glucuronate
boundary condition: false
constant: false
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_af79f4ba_cdc3_4668_9c7d_f33c99b3d500
name: ADH1B:ADH1C
constant: false
is: SBO:0000297
has part: P00326
initial concentration: NaN
type: Species
is encoded by: hsa:126
has only substance units: false
boundary condition: true
initial amount: NaN

metaM prpp e
initial concentration: 1.0
has only substance units: false
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB00280

metaR DALAt2r
product: MODEL1310110037#
reversible: true
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
is described by: ECO:0000304
fast: false
type: Reaction
reactant: MODEL1310110037#
name: D-alanine transport via proton symport
kinetic law: MODEL1310110037#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_81ed01c6_c4f8_498b_866b_e569cc352413
name: NDUFS7
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:374291
is: O75251
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR KHte
is: SBO:0000185
product: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
name: KHte
is described by: ECO:0000134
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110037#

metaM dnad c
boundary condition: false
initial amount: NaN
is: C00857
initial concentration: 1.0
is: SBO:0000247
is: HMDB01179
has only substance units: false
type: Species
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: CHEBI:18304
name: Deamino-NAD+
constant: false

metaR r0474
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110037#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_f88a5e0a_140c_4de7_b318_fb7fb5b826ab
initial amount: NaN
name: ENPP1
is encoded by: hsa:5167
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P22413
has only substance units: false
type: Species

metaR 2AMADPTm
is: SBO:0000185
product: MODEL1310110037#
is described by: ECO:0000269
reactant: MODEL1310110037#
modifier: MODEL1310110037#
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
name: L-2-aminoadipate shuttle (cytosol/mitochondria)

metaR VALTA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: valine transaminase
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110037#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
kinetic law: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_63aa6046_bf5b_41da_af32_0440ac59c278
is: SBO:0000252
boundary condition: true
name: _AI345944_1_m
initial amount: NaN
constant: false
is encoded by: hsa:AI345944
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_fff06b2e_86e7_4b1a_b6bf_186d5896a416
has only substance units: false
boundary condition: true
type: Species
name: HSD17B10
is encoded by: hsa:3028
constant: false
is: SBO:0000252
initial amount: NaN
is: Q99714
initial concentration: NaN

metaR MI14Ptn
product: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110037#
type: Reaction
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_5c64a15f_7e1e_4e12_8a79_78c156652991
name: SLC6A9
constant: false
is encoded by: hsa:6536
is: SBO:0000252
has only substance units: false
is: B7Z3W8
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR r1400
fast: false
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
reversible: false
reactant: MODEL1310110037#
name: Active transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaM lnlccoa c
has only substance units: false
is: HMDB01064
constant: false
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_959b5e32_def1_4e84_986f_2248e3eb2c53
initial amount: NaN
is: SBO:0000252
name: PAFAH1B3
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5050
type: Species
is: Q15102

http://identifiers.org/biomodels.db/MODEL1310110037#_30b44ad0_26a7_4b55_a58a_fdffb9223288
has part: O95498
is encoded by: hsa:55350
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8875
initial concentration: NaN
name: VNN3:VNN2:VNN1
is: SBO:0000297
has only substance units: false

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR r0698
modifier: MODEL1310110037#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
product: MODEL1310110037#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.27

metaR r0475
is described by: ECO:0000000
kinetic law: MODEL1310110037#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
fast: false
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_9aa742dd_8c25_4e47_afa2_0d30e6e348ba
constant: false
type: Species
is encoded by: hsa:48
initial amount: NaN
name: ACO1
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P21399
initial concentration: NaN

metaM sql r
initial concentration: 1.0
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
name: squalene
is: HMDB00256
has only substance units: false
is: CHEBI:15440
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN

metaM 3aib D m
is: C03265
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial concentration: 1.0
name: D-3-Amino-isobutanoate
is: HMDB02299

http://identifiers.org/biomodels.db/MODEL1310110037#_91f84e05_5681_44f0_910c_e765634908c8
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: SLC22A2
is encoded by: hsa:6582
type: Species
is: SBO:0000252

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR RDH3
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (11-cis,NADH)
type: Reaction
fast: false
reversible: true
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
kinetic law: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#

metaM gln L m
is: CHEBI:18050
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00641
name: L-glutamine
has only substance units: false
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaR XOL27OHtm
name: 27 hydroxy cholesterol transport
product: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reversible: true
is described by: ECO:0000000

metaM prpp c
initial concentration: 1.0
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
type: Species
is: C00119
constant: false
has only substance units: false
initial amount: NaN
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: CHEBI:58017
is: HMDB00280
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_1b6128b7_5282_49c4_986b_3667a5a9b81a
type: Species
initial amount: NaN
initial concentration: NaN
name: DHFR
is: P00374
is encoded by: hsa:1719
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

metaR RE1897C
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
name: RE1897
fast: false
type: Reaction
product: MODEL1310110037#
reactant: MODEL1310110037#

metaM dcdp n
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
initial concentration: 1.0
has only substance units: false
name: dCDP(3-)
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01245
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_912ba783_3dda_4b5a_ae04_07a7c4a9a70e
is: E9PB82
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: HSD17B4
has only substance units: false
is encoded by: hsa:3295

metaM glx c
is: CHEBI:36655
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: glyoxylate
constant: false
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN
is: HMDB00119
boundary condition: false

metaM odecoa c
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
initial concentration: 1.0
is: CHEBI:3793
boundary condition: false
is: HMDB01322
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_649b6215_3686_4fe8_9b91_3ba8c0742140
constant: false
has only substance units: false
name: _AL038231_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:AL038231
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r0472
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110037#
fast: false
type: Reaction
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_9ab6c776_a5d3_4ded_890e_1835d7c2a127
constant: false
is: SBO:0000252
is encoded by: hsa:57419
is: Q9HC58
has only substance units: false
boundary condition: true
name: SLC24A3
type: Species
initial amount: NaN
initial concentration: NaN

metaR r1560
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r2341
product: MODEL1310110037#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaR ICDHyrm
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reactant: MODEL1310110037#
name: Isocitrate dehydrogenase (NADP+)
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_46bc4f94_e6f1_48fa_b407_73259ba4d59f
initial amount: NaN
is: SBO:0000252
is: P11908
is encoded by: hsa:5634
constant: false
type: Species
boundary condition: true
name: PRPS2
has only substance units: false
initial concentration: NaN

metaR SERGLNexR
fast: false
name: L-Serine/Glutamine reversible exchange
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
reversible: true

metaR DCYTDn
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
modifier: MODEL1310110037#
name: deoxycytidine deaminase, nuclear
reversible: false
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.5
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_1e594f15_fd03_4efc_be5f_f3a2c4f3b6c8
name: SLC7A10
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9NS82
has only substance units: false
constant: false
is encoded by: hsa:56301
boundary condition: true
initial concentration: NaN

metaM arachdcoa m
is: HMDB06523
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
initial amount: NaN
is: CHEBI:57368
has only substance units: false
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR RDH2
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000269
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
name: retinol dehydrogenase (9-cis,NADH)
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
type: Reaction

metaM dcdp m
boundary condition: false
has only substance units: false
is: CHEBI:58593
name: dCDP(3-)
is: HMDB01245
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaR SBT Dtde
reversible: true
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
product: MODEL1310110037#
name: D-sorbitol transport, extracellular
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_5ef02e2e_f8a8_472a_bf9b_8ad4a4ac1bee
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:200010
type: Species
is: E9PAK4
name: SLC5A9

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaM hgentis c
has only substance units: false
is: HMDB00130
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:16169
name: homogentisate
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
initial concentration: 1.0

metaM amet c
is: HMDB01185
is: CHEBI:15414
type: Species
has only substance units: false
is: C00019
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: S-Adenosyl-L-methionine
is: SBO:0000247

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM fad e
constant: false
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
initial amount: NaN
is: C00016
has only substance units: false
type: Species
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
initial concentration: 1.0
is: CHEBI:16238

metaR HXPRT
type: Reaction
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
is: SBO:0000176
modifier: MODEL1310110037#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM ptth c
type: Species
initial amount: NaN
name: pantetheine
is: CHEBI:16753
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB03426
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831

metaM arachd r
constant: false
is: HMDB01043
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
has only substance units: false
type: Species
initial concentration: 1.0
name: arachidonate
boundary condition: false
is: SBO:0000247

metaR PE HSter
reversible: true
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
fast: false
name: phosphatidylethanolamine scramblase
is: SBO:0000185
reactant: MODEL1310110037#

metaR NACASPAH
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: N-Acetyl-L-aspartate amidohydrolase
fast: false
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
is version of: http://identifiers.org/ec-code/3.5.1.15
is: SBO:0000176
type: Reaction
reversible: false

metaR CYTK13n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: cytidylate kinase (dCMP,dATP),nuclear
is described by: ECO:0000269
fast: false
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true

metaR r2326
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true
is: SBO:0000185
reactant: MODEL1310110037#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110037#
fast: false

metaR GLCt4
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
name: glucose transport via sodium symport
fast: false
reversible: true

metaR DRIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
type: Reaction
name: deoxyribose transport via diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110037#

metaM pail hs n
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: SBO:0000247
initial amount: NaN
is: CHEBI:57880
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false

metaM ncam c
is: SBO:0000247
name: Nicotinamide
is: HMDB01406
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H6N2O CHARGE: 0
constant: false
initial amount: NaN
is: C00153
boundary condition: false
is: CHEBI:0
type: Species

metaM leu L c
is: CHEBI:15603
initial concentration: 1.0
constant: false
is: HMDB00687
type: Species
initial amount: NaN
boundary condition: false
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
has only substance units: false

metaM CE5586 c
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:58732
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_30657474_2473_4512_b299_c3fd3d1b1468
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:23428
type: Species
name: SLC7A8:SLC3A2
is: SBO:0000297
has only substance units: false
has part: Q86U05

metaM crmp hs c
name: ceramide 1-phosphate(2-)
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C18H35NO5PFULLRCO CHARGE: -2 EHMN_ABBREVIATION: C02960
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57674
has only substance units: false
constant: false

metaM 3dhguln c
is: HMDB06334
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57655
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
type: Species
has only substance units: false
constant: false
name: 3-dehydro-L-gulonate

http://identifiers.org/biomodels.db/MODEL1310110037#_374133fc_2516_46c0_8295_67ceaa893646
is: SBO:0000252
is encoded by: hsa:2875
constant: false
is: P24298
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: GPT
initial concentration: NaN

metaM ha l
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
is: CHEBI:16336
initial concentration: 1.0
is: SBO:0000247
name: hyaluronan
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_bfc9d9ef_3187_4f36_893d_73c0e63205d3
is: Q02221
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1339
name: COX6A2
is: SBO:0000252
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_b913cc03_3ebc_4999_8bcc_4942f072182e
is: P28332
is: SBO:0000252
type: Species
constant: false
name: ADH6
initial amount: NaN
is encoded by: hsa:130
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_3241f0f2_fcfa_4e66_9bf4_594065463345
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: P08319
name: ADH4
is encoded by: hsa:127

metaM ala B e
boundary condition: false
is: CHEBI:16958
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00056
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM leu L e
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
name: L-leucine
is: CHEBI:15603
is: HMDB00687
is: SBO:0000247
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0

metaR r2325
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110037#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM xu5p D c
initial concentration: 1.0
is: CHEBI:57737
name: D-xylulose 5-phosphate(2-)
constant: false
is: HMDB00868
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
has only substance units: false
is: SBO:0000247

metaR RE1520M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is described by: ECO:0000000
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1520
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_267a1293_bcb2_4092_9773_0a11be7f6606
has part: P14854
is encoded by: hsa:4512
has part: P20674
is encoded by: hsa:1339
initial amount: NaN
has part: P15954
is encoded by: hsa:1346
is encoded by: hsa:1329
is encoded by: hsa:1351
has part: Q96KJ9
has part: P12074
is encoded by: hsa:84701
constant: false
has part: Q53XN1
is: SBO:0000297
is encoded by: hsa:1350
has part: Q7Z4L0
is encoded by: hsa:1337
is encoded by: hsa:1340
type: Species
is encoded by: hsa:1345
has part: P09669
is encoded by: hsa:4514
has only substance units: false
is encoded by: hsa:9377
is encoded by: hsa:1347
is encoded by: hsa:9167
has part: Q7GXY8
is encoded by: hsa:125965
has part: P13073
has part: Q7GXZ8
has part: Q53YB7
is encoded by: hsa:1327
boundary condition: true
is encoded by: hsa:341947
has part: Q02221
has part: Q6YFQ2
has part: Q8TF08
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P24310
has part: P24311
is encoded by: hsa:1349
is encoded by: hsa:4513
has part: H0UI06
has part: P00414
initial concentration: NaN
is encoded by: hsa:170712
has part: Q6FGA0

http://identifiers.org/biomodels.db/MODEL1310110037#_671caf53_c864_4ca1_b3f4_f1f6661ae242
initial amount: NaN
type: Species
name: PFKL
is: SBO:0000252
is encoded by: hsa:5211
has only substance units: false
constant: false
initial concentration: NaN
is: P17858
boundary condition: true

metaM triodthy c
name: 3,3',5-triiodo-L-thyronine
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: CHEBI:18258
is: SBO:0000247
is: HMDB00265
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465

http://identifiers.org/biomodels.db/MODEL1310110037#_9a07ed80_5a01_4fb7_96d5_fabac6589c12
is encoded by: hsa:80704
is: Q9BZV2
has only substance units: false
name: SLC19A3
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_814b01b6_26cd_4414_af4e_52d194472320
boundary condition: true
is encoded by: hsa:83715
name: ESPN
is: B1AK53
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_3019697c_d461_4a65_92a1_941eb82212ae
is: Q8TBF5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:54965
initial amount: NaN
type: Species
constant: false
name: PIGX

metaR MAN6PI
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/5.3.1.8
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: mannose-6-phosphate isomerase
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000304

metaM 2oxoadp m
initial concentration: 1.0
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57499
is: HMDB00225
constant: false
name: 2-oxoadipate(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_2816774f_e4fb_4718_9783_c6e9d48639c5
is encoded by: hsa:2937
is: P48637
boundary condition: true
name: GSS
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

metaR H2Otp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110037#
fast: false
product: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
name: H2O transport, peroxisomal

metaR RE0958E
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110037#
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0958
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_31202653_bc84_4714_abb8_475a63d51280
is: SBO:0000252
initial concentration: NaN
is: O75106
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:314
boundary condition: true
type: Species
name: AOC2

metaM dhlam m
name: dihydrolipoamide
is: CHEBI:17694
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
constant: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
is: HMDB00985
has only substance units: false

metaR NMNATr
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110037#
fast: false
reversible: true
modifier: MODEL1310110037#
name: nicotinamide-nucleotide adenylyltransferase
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.7.1
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_872048e0_06f6_4fcb_8a1a_ee8d5567403f
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: MCCC2
type: Species
is: Q9HCC0
boundary condition: true
is encoded by: hsa:64087

metaR r1589
is described by: ECO:0000000
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
reactant: MODEL1310110037#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#

metaR r2324
product: MODEL1310110037#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_9440860a_ebed_480b_bf6f_bd5cab3da865
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: _AI469183_1_x
is encoded by: hsa:AI469183
type: Species
initial concentration: NaN
initial amount: NaN

metaM ncam e
is: HMDB01406
name: Nicotinamide
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H6N2O CHARGE: 0
is: C00153
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:0
type: Species

metaR FAOXC1811603m
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR LPS3e
name: lipase, extracellular
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.3
reactant: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
kinetic law: MODEL1310110037#
type: Reaction

W3 CDTF: Thu Aug 30 16:03:45 BST 2012

metaR SRTNt6 2 r
reactant: MODEL1310110037#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
modifier: MODEL1310110037#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_ac2ae9b4_fbb1_42f9_87cf_23e6cfd50a9d
is encoded by: hsa:10873
has only substance units: false
type: Species
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q6TCH8
name: ME3

http://identifiers.org/biomodels.db/MODEL1310110037#_dff70a43_16b9_4bdc_8528_3652cc3ce98a
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AD000092
constant: false
name: _AD000092_1_c

metaR r2323
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110037#
fast: false
is: SBO:0000185

metaM sbt D c
constant: false
initial amount: NaN
is: CHEBI:17924
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: SBO:0000247
name: D-glucitol
boundary condition: false
has only substance units: false
is: HMDB00247
initial concentration: 1.0
type: Species

metaM arachcrn c
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false
has only substance units: false
is: HMDB06460
initial concentration: 1.0
type: Species
name: arachidyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110037#_8feafa05_b075_4f0a_b6fe_c2f5dae39aca
is: Q86YI5
type: Species
is encoded by: hsa:1737
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: DLAT

http://identifiers.org/biomodels.db/MODEL1310110037#_4c81b10e_0965_43ee_9b79_0056590e586c
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:29926
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: GMPPA

metaR CGLYt3 2
is described by: ECO:0000304
reactant: MODEL1310110037#
is: SBO:0000185
fast: false
type: Reaction
reversible: false
product: MODEL1310110037#
name: Cys-Gly transport in via proton symport
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM CE5160 r
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 3-oxo-cis-9-octadecenoyl-CoA
type: Species
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
is: HMDB00127
constant: false
is: CHEBI:15748
has only substance units: false

W3 CDTF: Thu Aug 30 16:03:45 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110037#_7fe206ed_43a2_4973_8856_9bb5b8b34346
initial concentration: NaN
type: Species
is: Q969I6
has only substance units: false
is: SBO:0000252
name: SLC38A4
boundary condition: true
constant: false
is encoded by: hsa:55089
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_5c16bd0e_7f08_465f_8946_4d276016d3b2
initial amount: NaN
type: Species
is: P09972
name: ALDOC
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:230
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_d81faeb3_2de7_44fd_a7b0_28d20794fd0f
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3418
constant: false
name: IDH2
initial amount: NaN
initial concentration: NaN
is: P48735
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_da99cc21_c3a5_4ff7_beba_37862d8dc2a0
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: _AI640625_1_c
initial amount: NaN
is encoded by: hsa:AI640625
boundary condition: true
initial concentration: NaN

metaR DADA
product: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4
reversible: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
kinetic law: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
type: Reaction
is described by: ECO:0000269
name: Deoxyadenosine deaminase

metaR r1587
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000

metaM chsterol c
name: chsterol[c]
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: CHARGE: 0
is: HMDB00067
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r0236
reactant: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.1.6
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110037#
is described by: ECO:0000000
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
fast: false

metaR H2Otn
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
name: H2O transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR r1467
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
type: Reaction
name: Postulated transport reaction

metaM Rtotal3coa c
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:16189
name: R total 3 Coenzyme A
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01448

metaR URIt4
kinetic law: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
modifier: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is: SBO:0000185
name: uridine transport in via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110037#_9a05951c_4e50_40fd_ac26_54744f8a15bf
name: _AA526438_1_m
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA526438
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_7a9ee00a_baab_484e_91a1_a3755c309975
boundary condition: true
initial amount: NaN
is encoded by: hsa:4846
is: A0S0A7
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
name: NOS3

metaR CITt4 4
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
name: citrate transport via sodium symport
kinetic law: MODEL1310110037#
is described by: ECO:0000006
reversible: true
fast: false
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
type: Reaction

metaM dha e
is: SBO:0000247
name: glycerone
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
boundary condition: false
is: HMDB01882
type: Species
has only substance units: false
is: CHEBI:16016
initial amount: NaN
initial concentration: 1.0
constant: false

metaM HC00591 c
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial concentration: 1.0
name: 2-oxoglutaramate
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: CHEBI:16769
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_35c6a6ec_f608_4d11_973a_3e7fc523a6e8
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:10005
boundary condition: true
name: ACOT8
has only substance units: false
is: SBO:0000252
is: O14734

http://identifiers.org/biomodels.db/MODEL1310110037#_d94c486f_d93e_43c5_b374_88b02bd65501
is: SBO:0000252
name: ADO
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:84890
is: B3KXN9
boundary condition: true
has only substance units: false

metaM adp c
constant: false
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:16761
name: ADP
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00008
type: Species

metaR 5ADTSTSTERONEtr
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
name: 5 alpha dihydrotesterone intracellular transport
reversible: true
fast: false
reactant: MODEL1310110037#
is: SBO:0000185

metaR BTNt4i
reversible: false
product: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
is described by: ECO:0000269
name: Biotin uptake (antiport)
reactant: MODEL1310110037#
is: SBO:0000185
fast: false
type: Reaction

metaR r1019
product: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_453f5716_bb3d_455a_b99a_10f7eaaf5004
has only substance units: false
is: SBO:0000252
name: PDHX
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8050
initial amount: NaN
is: O00330
type: Species

metaR r1588
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
reversible: true
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110037#_6be6128f_48f0_4fe3_a8ba_972731a42355
initial amount: NaN
name: ALDH9A1
boundary condition: true
constant: false
is: P49189
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:223
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_8475ce56_09ce_44de_8af2_abb2b31a5ef9
name: _BE042354_1_m
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:BE042354
boundary condition: true
initial concentration: NaN

metaR r1018
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110037#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
name: Transport reaction

metaR CYSGLYexR
type: Reaction
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: L-cysteine/glycine reversible exchanger
product: MODEL1310110037#

metaR r1466
is: SBO:0000176
type: Reaction
name: EC:2.3.1.86
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000

metaM sbt D e
constant: false
initial amount: NaN
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
name: D-glucitol
is: SBO:0000247
is: HMDB00247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR PECDCHe
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR DNDPt33m
reactant: MODEL1310110037#
name: dGDP transport via dUDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110037#_2dfcb340_34a3_425e_8a93_58d2f45d7b63
is: SBO:0000252
is: P23368
is encoded by: hsa:4200
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: ME2

metaM frdp r
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: C00448
name: Farnesyl diphosphate
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
is: CHEBI:175763
is: HMDB00961
has only substance units: false

metaM HC00460 c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
name: 2,5-dihydroxybenzoate
constant: false
is: SBO:0000247
is: CHEBI:58044

metaR RE2349C
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: RE2349
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
fast: false
is described by: ECO:0000000
modifier: MODEL1310110037#
reversible: true

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR r2329
type: Reaction
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1585
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#

metaR GTHP
name: glutathione peroxidase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
fast: false
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is described by: ECO:0000134
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
reversible: true

metaR DNDPt38m
is described by: ECO:0000269
is: SBO:0000185
name: dUTP transport via dUDP antiport
reversible: false
fast: false
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_1b35b7e9_650d_4239_ac6d_eec08bd7a456
has only substance units: false
initial amount: NaN
is: P47895
is encoded by: hsa:220
is: SBO:0000252
initial concentration: NaN
type: Species
name: ALDH1A3
boundary condition: true
constant: false

metaR r2328
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110037#_0dda88a9_380d_47c1_981f_90bfc732f426
is encoded by: hsa:276
is: P04745
name: AMY1A
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR r0129
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110037#
reversible: true
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110037#
fast: false

metaM gmp c
is: C00144
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
is: SBO:0000247
name: GMP
is: HMDB01397
boundary condition: false
constant: false
type: Species
is: CHEBI:58115

metaR r0009
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: false
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.6.1.1

metaR NACDe
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaM dhcrm hs c
name: dihydroceramide
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:31488
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR H2Otm
is described by: ECO:0000269
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
reversible: true
name: H2O transport, mitochondrial
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
type: Reaction

metaR r1586
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110037#

metaR r2327
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110037#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true

metaR r1464
fast: false
reversible: true
is described by: ECO:0000000
name: Active transport
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110037#
product: MODEL1310110037#

metaR FADDPle
fast: false
name: FAD diphosphatase
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000134
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110037#

metaM gpail hs c
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:17049
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248

metaM 34dhpac c
type: Species
initial amount: NaN
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:27978
is: HMDB03791
name: 3,4-Dihydroxyphenylacetaldehyde
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_3fd48e66_6f20_4fa7_915c_07a04c30d2f9
initial concentration: NaN
is: SBO:0000252
is: Q6LEN6
constant: false
type: Species
boundary condition: true
is encoded by: hsa:1103
name: CHAT
has only substance units: false
initial amount: NaN

metaR VALPHELAT2tc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR RADH2
is: SBO:0000176
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinal dehydrogenase (NADPH)
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_6e579db2_2c09_433c_9cc5_a9977dfdc608
constant: false
type: Species
is: SBO:0000252
is: P56556
name: NDUFA6
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:4700

http://identifiers.org/biomodels.db/MODEL1310110037#_b4a5e03d_7fed_4b93_8663_0c5f45cec16c
is: O75912
constant: false
has only substance units: false
is encoded by: hsa:9162
type: Species
name: DGKI
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM dgpi prot hs r
boundary condition: false
type: Species
is: CHEBI:16004
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01311
constant: false
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
initial amount: NaN
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110037#_9bc93cb6_abae_47d1_a4df_a7335ccfcf4a
name: SLC27A1
is: Q6PCB7
boundary condition: true
initial concentration: NaN
is encoded by: hsa:376497
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_7eca741b_aa83_4dc5_930e_9683a8e7b88d
is encoded by: hsa:4357
is: P25325
has only substance units: false
name: MPST
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaR r1615
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
fast: false

metaR IDPtn
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
product: MODEL1310110037#
name: IDP nuclear transport
reactant: MODEL1310110037#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM ha e
has only substance units: false
name: hyaluronan
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: CHEBI:16336

http://identifiers.org/biomodels.db/MODEL1310110037#_74b10c2c_b975_46fe_b12d_b1bb4acf240e
type: Species
is: SBO:0000252
boundary condition: true
name: ACADL
has only substance units: false
is: P28330
initial concentration: NaN
constant: false
is encoded by: hsa:33
initial amount: NaN

metaM arach c
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
has only substance units: false
is: HMDB02212
name: arachidate
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:32360
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_dd5a444f_6fd2_4271_824d_3178ca40cf15
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: GOT1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2805
is: P17174
constant: false

metaM CE2435 m
constant: false
type: Species
is: CHEBI:57795
name: trans,cis-deca-2,4-dienoyl-CoA
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR NDPK2
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
kinetic law: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP)
is: SBO:0000176
modifier: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_1af189d5_9ee6_488c_9a25_232ee7ceb232
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:353
name: APRT
has only substance units: false
initial amount: NaN
type: Species
is: P07741
constant: false
boundary condition: true

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM ser D e
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
initial concentration: 1.0
constant: false
has only substance units: false
name: D-serine

metaR PFK
product: MODEL1310110037#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110037#
name: phosphofructokinase
is version of: http://identifiers.org/ec-code/2.7.1.11

metaR NDPK3m
reactant: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
fast: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
reversible: true
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000176

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_39f9610c_5f89_493a_83c4_e9f52c9afeca
constant: false
initial amount: NaN
name: HIBCH
type: Species
initial concentration: NaN
is: Q6NVY1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:26275
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_53a25c78_99fc_4990_a0af_f2bcac24e145
type: Species
initial amount: NaN
constant: false
name: ATP2B3
initial concentration: NaN
is encoded by: hsa:492
has only substance units: false
is: SBO:0000252
is: Q16720
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_7ffb02cc_6023_4caf_9008_8b37114f3fb2
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: _AU149534_1_m
is encoded by: hsa:AU149534
initial concentration: NaN

metaR r1614
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_013fe9a8_1975_4c9f_a053_155d2f24b589
type: Species
constant: false
is encoded by: hsa:9488
name: PIGB
is: SBO:0000252
is: Q92521
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_2d171f51_82e5_4239_bf87_c4c2e6f25dd6
boundary condition: true
name: AADAT
is: Q8N5Z0
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51166
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_4a849afb_2138_4700_94f5_88e68d1870d4
initial amount: NaN
constant: false
is: P00918
is encoded by: hsa:760
initial concentration: NaN
name: CA2
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaR r2034
reactant: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110037#
reversible: false
type: Reaction

metaR NDPK3
is: SBO:0000176
modifier: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:CDP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
product: MODEL1310110037#

metaR r0097
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
reactant: MODEL1310110037#
reversible: false
is described by: ECO:0000000
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_41392f15_840f_4a4f_96ba_bc7dd2488aa9
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ACSS2
type: Species
initial amount: NaN
is: Q5QPH3
constant: false
boundary condition: true
is encoded by: hsa:55902

metaM bilirub c
name: bilirubin(2-)
is: SBO:0000247
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00054

metaR URATEt
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110037#
fast: false
name: urate export from cytosol
type: Reaction
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM leu L m
is: SBO:0000247
name: L-leucine
is: CHEBI:15603
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
initial amount: NaN

metaR NDPK3n
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_22c3df32_d95b_42fd_ad71_5ee292944c2c
initial concentration: NaN
is encoded by: hsa:160851
constant: false
name: DGKH
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: A8K0I1
initial amount: NaN

metaR RBTt
reactant: MODEL1310110037#
name: ribitol transport via passive diffusion
product: MODEL1310110037#
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_59c40462_3208_4908_8582_487356d798ae
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:8612
is: E9PAY8
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: PPAP2C

metaM q10 m
has only substance units: false
name: ubiquinone-10
is: SBO:0000247
is: HMDB01072
is: CHEBI:46245
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
type: Species
initial amount: NaN

metaM thbpt4acam c
is: CHEBI:15374
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB02281
initial amount: NaN
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
constant: false
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
type: Species

metaM arachcrn m
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: arachidyl carnitine
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: HMDB06460
constant: false
initial amount: NaN
boundary condition: false

metaM CE2838 e
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
is: C01936
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: SBO:0000247
type: Species
initial amount: NaN
name: maltononaose
constant: false

metaR r1617
modifier: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000185
product: MODEL1310110037#
reactant: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 13 cis retn r
is: D00348
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06219
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/7847414
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
has only substance units: false
type: Species
name: 13-cis-retinoate

metaR OROTGLUt
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: OROTGLUt
is described by: ECO:0000134
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_55fc9e8e_a9b0_4d96_9f06_704cb00fd908
initial amount: NaN
constant: false
boundary condition: true
is: P59796
type: Species
name: GPX6
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:257202

http://identifiers.org/biomodels.db/MODEL1310110037#_eeb30644_4da4_4184_be6b_d533ed6b0fd0
is encoded by: hsa:286016
boundary condition: true
has only substance units: false
is: SBO:0000252
name: TPI1P2
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

metaM ser D c
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
type: Species
name: D-serine
is: SBO:0000247
is: CHEBI:16523
is: HMDB03406

metaR DNDPt17m
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
is described by: ECO:0000269
type: Reaction
name: dUDP transport via dCDP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110037#
product: MODEL1310110037#
fast: false

metaR ADRNt
fast: false
type: Reaction
product: MODEL1310110037#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_77ac633a_ab1e_459a_9c40_68abc6cb22a0
initial concentration: NaN
is: O95299
is encoded by: hsa:4705
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: NDUFA10
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_abb9fc81_2847_404c_a0ec_a841356b18d4
has only substance units: false
initial concentration: NaN
type: Species
name: NME1
is encoded by: hsa:4830
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P15531

metaR r1616
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dgchol c
is: HMDB00637
name: glycochenodeoxycholate
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false
is: CHEBI:36252
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_30ea0b59_335a_4272_99b4_1b390b9c4dae
has part: P36957
is: SBO:0000297
type: Species
initial amount: NaN
has part: O00330
has part: Q02218
has part: P09622
is encoded by: hsa:8050
constant: false
is encoded by: hsa:1738
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1743
name: DLD:DLST:OGDH:PDHX
is encoded by: hsa:4967
boundary condition: true

metaR ASPNATm
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
name: aspartate N-acetyltransferase, mitochondrial

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM 34dhmald c
is: http://identifiers.org/pubchem.compound/7903
boundary condition: false
is: HMDB06242
is: C05577
constant: false
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_7c5374fc_616d_4992_ad98_b96c4e873591
is: P22392
type: Species
has only substance units: false
name: NME2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4831
initial amount: NaN
constant: false
initial concentration: NaN

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_72d0b688_ffeb_498a_8d3e_7dc56fd46efd
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: SLC16A10
initial amount: NaN
is encoded by: hsa:117247
is: Q8TF71
has only substance units: false
boundary condition: true

metaM bilirub e
is: CHEBI:57977
name: bilirubin(2-)
type: Species
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: HMDB00054
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_b13fad5e_8abe_48cf_be52_31b0cae7e55b
initial amount: NaN
is encoded by: hsa:277
is: P04745
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: AMY1B
initial concentration: NaN
boundary condition: true

metaR GLNtm
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
fast: false
is: SBO:0000185
reactant: MODEL1310110037#
name: L-glutamine transport via electroneutral transporter
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_e6a81432_45f3_4a1c_bbbe_f06530383891
constant: false
is: P00492
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3251
has only substance units: false
type: Species
initial concentration: NaN
name: HPRT1

metaR NDPK1
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:GDP)
kinetic law: MODEL1310110037#
fast: false
is described by: ECO:0000134
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_e59d794a_b2d9_40cd_a1e1_3b7a616d1023
is: SBO:0000252
boundary condition: true
constant: false
name: _D29675_1_c
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:D29675

W3 CDTF: Thu Aug 30 16:03:45 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110037#_3833daf6_21fe_4374_8f1b_efc935b59899
is: P23434
type: Species
initial concentration: NaN
name: GCSH
has only substance units: false
initial amount: NaN
is encoded by: hsa:2653
boundary condition: true
is: SBO:0000252
constant: false

metaM itp n
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
is: HMDB00189
constant: false
name: ITP(3-)
type: Species
boundary condition: false
is: CHEBI:57614
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r1619
is described by: ECO:0000000
modifier: MODEL1310110037#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PGCD
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.95
reversible: false
name: phosphoglycerate dehydrogenase
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_99c46d7b_2ae7_4118_a678_e4d2aa443f9d
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is: P41247
is encoded by: hsa:8228
initial concentration: NaN
has only substance units: false
name: PNPLA4
type: Species

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_8754acc0_57e6_4fcf_a015_ade327eeec28
is encoded by: hsa:10166
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC25A15
is: Q9Y619

metaR THBPT4ACAMDASE
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110037#
fast: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM leuktrB4 c
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01085
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: CHEBI:57461
type: Species
name: leukotriene B4(1-)

metaR ARACHDtr
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false
is described by: ECO:0000000
product: MODEL1310110037#
type: Reaction
name: intracellular transport
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaR RTOTAL3t
reversible: true
is described by: ECO:0000000
name: RTOTAL3 transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#

metaM dcyt n
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
initial amount: NaN
type: Species
is: CHEBI:15698
is: SBO:0000247
initial concentration: 1.0
is: HMDB00014
has only substance units: false
name: 2'-deoxycytidine
boundary condition: false

metaR NDPK6
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
is: SBO:0000176
fast: false
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR BHBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate transport via H+ symport
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000185

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR NADS2
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
name: NAD synthase (glutamine-hydrolysing)
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.3.5.1
reversible: false
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_24397d6c_e09f_428e_b5cc_31fdf3939b83
boundary condition: true
is encoded by: hsa:441024
is: SBO:0000252
is: Q9H903
initial amount: NaN
name: MTHFD2L
initial concentration: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_47389409_a61a_4311_8957_1297023271d6
is: SBO:0000252
has only substance units: false
is: O76082
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6584
name: SLC22A5
initial concentration: NaN
type: Species

W3 CDTF: Thu Aug 30 16:03:45 BST 2012

metaR GTHRDt
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
fast: false
product: MODEL1310110037#
name: Glutathione transport into mitochondria
reactant: MODEL1310110037#
is: SBO:0000185

metaR r1618
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM hdcea c
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: CHEBI:32372
is: HMDB03229
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_b01dfd6a_5ab5_45df_8a76_d75634b8e97f
name: UPP1
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:7378
boundary condition: true
is: SBO:0000252
constant: false

metaM dgchol e
name: glycochenodeoxycholate
is: SBO:0000247
is: CHEBI:36252
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00637

metaM btn c
is: C00120
initial concentration: 1.0
name: Biotin
initial amount: NaN
is: CHEBI:3420
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false
boundary condition: false

metaR DGAT
name: diacylglycerol acyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
modifier: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
fast: false
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.20
reversible: false
product: MODEL1310110037#

metaR r0002
name: Active transport
reactant: MODEL1310110037#
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:

metaM arachd e
is: HMDB01043
name: arachidonate
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM glu5sa m
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB02104
name: L-Glutamate 5-semialdehyde
boundary condition: false
is: CHEBI:17232
is: C01165

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_bd391dfb_2a32_40b8_af56_c6b943a99062
is: SBO:0000252
initial concentration: NaN
is: P57054
name: PIGP
is encoded by: hsa:51227
type: Species
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

metaR H6ET3er
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.1
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
product: MODEL1310110037#
is described by: ECO:0000000

metaR NDPK7
is: SBO:0000176
product: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:dCDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000269
fast: false
type: Reaction

metaR r2067
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
kinetic law: MODEL1310110037#
type: Reaction
reversible: false
product: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#

metaR 34DHPLACOX NADP
product: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
modifier: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is described by: ECO:0000269

metaM tre e
is: CHEBI:16551
is: C01083
type: Species
is: HMDB00975
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
name: Trehalose
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM ile L m
type: Species
name: L-isoleucine
boundary condition: false
initial concentration: 1.0
is: CHEBI:17191
is: SBO:0000247
has only substance units: false
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_d28c88ca_f2fa_4037_b15a_1923aada7868
is encoded by: hsa:410
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P15289
name: ARSA
initial concentration: NaN
constant: false
type: Species

metaM CE2422 m
has only substance units: false
is: CHEBI:28387
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
initial amount: NaN
is: HMDB11123
boundary condition: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110037#_df8198c0_a6b9_467a_ac0a_ce1f0518a77b
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: ALDOA
is encoded by: hsa:226
initial concentration: NaN
boundary condition: true

metaR FAEL183
is: SBO:0000176
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is described by: ECO:0000000
type: Reaction
name: fatty-acyl-CoA elongation (n-C18:3CoA)
product: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
reactant: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_175a1080_eddb_47d1_b2e7_1a1f8aa0f4b9
is encoded by: hsa:51604
is: SBO:0000297
has part: Q969N2
constant: false
is encoded by: hsa:10026
has part: Q9H490
is encoded by: hsa:8733
has part: O43292
initial amount: NaN
has part: Q8NBL9
is encoded by: hsa:128869
name: PIGK:PIGU:PIGT:GPAA1:PIGS
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:94005
has part: Q92643
has only substance units: false

metaM arach e
constant: false
name: arachidate
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:32360
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: HMDB02212
has only substance units: false
initial concentration: 1.0

metaR NDPK4
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP)
kinetic law: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000269

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM 5htrp c
name: 5-hydroxy-L-tryptophan
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
type: Species
is: HMDB00472
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:17780
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC200180m
reversible: false
name: Beta oxidation of long chain fatty acid
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
type: Reaction

metaR PROSTGE2t2
reversible: true
product: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
fast: false
name: prostaglandin uniport
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269

metaM lald D c
is: SBO:0000247
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB06458
is: CHEBI:17167
boundary condition: false
type: Species
initial amount: NaN
name: (R)-lactaldehyde

metaM cholcoa x
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:57373
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: choloyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110037#_b1efb1c7_32ef_4a85_8085_0d6c5a589425
constant: false
name: NDUFS2
is encoded by: hsa:4720
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: B7Z792
type: Species
is: SBO:0000252

metaR GGH 10FTHF7GLUl
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (10FTHF7GLU), lysosomal
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110037#_10e626e7_fa6b_41be_b78f_6b7248f1d7ac
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6391
name: SDHC
is: SBO:0000252
is: Q99643
boundary condition: true

metaM btn e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: C00120
boundary condition: false
is: SBO:0000247
is: CHEBI:3420
type: Species
is: HMDB00030
constant: false

metaM hdcea e
is: HMDB03229
constant: false
is: CHEBI:32372
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: Hexadecenoate (n-C16:1)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_e231571f_fa8e_48ed_85d9_86bce0d9df16
initial concentration: NaN
is encoded by: hsa:AV717590
constant: false
boundary condition: true
initial amount: NaN
name: _AV717590_1_m
type: Species
has only substance units: false
is: SBO:0000252

metaR r0122
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110037#
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_aeeb5c0a_8139_4ef5_9060_7e4e041498b9
is encoded by: hsa:23517
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q3MHC9
constant: false
has only substance units: false
name: SKIV2L2

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_67cf755e_f53f_424e_9126_65b4c8a83f67
constant: false
is encoded by: hsa:10599
is: Q9Y6L6
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SLCO1B1
is: SBO:0000252

metaR r0801
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110037#

metaR PPNCL3
is: SBO:0000176
product: MODEL1310110037#
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110037#
name: phosphopantothenate-cysteine ligase
is described by: ECO:0000269
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.3.2.5

metaR NDPK5
reactant: MODEL1310110037#
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dGDP)
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
type: Reaction
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_d6c31ec1_42d9_40a7_a28f_c804c8e3272d
initial amount: NaN
boundary condition: true
is encoded by: hsa:64841
is: SBO:0000252
type: Species
constant: false
name: GNPNAT1
has only substance units: false
initial concentration: NaN
is: Q96EK6

metaR GLYCTO1p
name: Glycolate oxidase, peroxisome
type: Reaction
reactant: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.3.15
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
fast: false
modifier: MODEL1310110037#
is described by: ECO:0000269
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_4f8dabeb_0b8c_4087_b434_47291cb443cf
is: SBO:0000252
name: SLC38A5
is: Q8WUX1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:92745
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR LEUKTRA4t
product: MODEL1310110037#
name: leukotriene A4 transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_9ee78836_b0f7_4c3b_813f_4d32e935be45
initial amount: NaN
is: Q5FWE9
is encoded by: hsa:134526
name: ACOT12
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR FOLt2le
fast: false
reactant: MODEL1310110037#
name: folate transport via anion exchange
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110037#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110037#_9e0ef7d3_e11d_48f1_ad83_1fd0285cd841
is encoded by: hsa:19
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ABCA1
constant: false
is: O95477
is: SBO:0000252
initial amount: NaN

metaM gpi prot hs r
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00220
is: C00249
boundary condition: false
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
is: CHEBI:7896
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110037#_b9e0eed1_17b5_4720_a59a_dc3c95fe6e0e
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:80025
initial concentration: NaN
has only substance units: false
name: PANK2

metaM arachdcrn c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57387
constant: false
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: HMDB01322
boundary condition: false
type: Species
is: SBO:0000247

metaR CYANtm
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
kinetic law: MODEL1310110037#
type: Reaction
name: Cyanide transport via diffusion (mitochondrial)
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110037#

metaM adp n
is: HMDB01341
boundary condition: false
has only substance units: false
name: ADP(3-)
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
is: CHEBI:456216
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_58383bc1_a1d9_49d3_acc0_53f56d3c4748
initial concentration: NaN
name: SLC13A4
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:26266
initial amount: NaN
is: Q9UKG4
has only substance units: false
boundary condition: true

metaR r2100
modifier: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110037#

metaM strdnc r
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: C16300
is: http://identifiers.org/pubchem.compound/47205608
initial concentration: 1.0
is: HMDB06547
type: Species
initial amount: NaN
name: stearidonic acid C18:4, n-3

metaM dcamp c
initial concentration: 1.0
is: HMDB00536
boundary condition: false
is: CHEBI:57567
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: N6-(1,2-Dicarboxyethyl)-AMP
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
type: Species
constant: false
is: C03794

http://identifiers.org/biomodels.db/MODEL1310110037#_fa95c754_1daf_43e3_b493_cc3641000173
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2544
has only substance units: false
name: _2544_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_b201fb93_a769_45b8_acdf_e0ca6b9583ce
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: CROT
is encoded by: hsa:54677
is: SBO:0000252
constant: false
is: E7EQF2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_2a1e754c_f2da_44b4_8eb8_0f9b72f832e2
is encoded by: hsa:217
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: ALDH2
type: Species
is: P05091
initial concentration: NaN
is: SBO:0000252

metaM itaccoa m
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB03377
name: itaconyl-CoA(5-)
has only substance units: false
is: CHEBI:57381
initial amount: NaN
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_6baae982_648c_4108_91f2_3053b7bee60b
initial amount: NaN
type: Species
is: SBO:0000252
is: Q8NFW8
constant: false
has only substance units: false
name: CMAS
is encoded by: hsa:55907
boundary condition: true
initial concentration: NaN

metaR r0726
is version of: http://identifiers.org/ec-code/2.7.1.33
modifier: MODEL1310110037#
product: MODEL1310110037#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110037#

metaM icit m
initial concentration: 1.0
is: CHEBI:16087
boundary condition: false
constant: false
is: SBO:0000247
name: Isocitrate
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
type: Species
is: HMDB00193
is: C00311

metaR r0559
fast: false
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_0f3287c9_0a6c_449e_a68f_be12e575a43e
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: NDUFV3
is: P56181
initial amount: NaN
is encoded by: hsa:4731
initial concentration: NaN

metaR NDPK9
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110037#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:IDP)
is described by: ECO:0000269
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
type: Reaction

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

metaR r0130
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true

metaM hom L c
initial amount: NaN
type: Species
name: L-homoserine
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
boundary condition: false
is: CHEBI:15699
is: HMDB00719
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_d063d709_679b_4844_969c_bbf8221ea615
boundary condition: true
initial concentration: NaN
type: Species
name: NOS1
constant: false
initial amount: NaN
is encoded by: hsa:4842
is: B4DG68
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_b895cc5e_6292_49a4_81b0_656209536dd2
name: SOD3
is encoded by: hsa:6649
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P08294
constant: false
type: Species
is: SBO:0000252

metaR DADAe
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is described by: ECO:0000269
name: Deoxyadenosine deaminase, extracellular
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.4
fast: false
kinetic law: MODEL1310110037#

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_57b7f29b_6ede_4698_bf92_1d0d46638da3
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4712
boundary condition: true
is: O95139
constant: false
initial amount: NaN
name: NDUFB6

metaM retn r
constant: false
is: CHEBI:35291
name: all-trans-retinoate
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
has only substance units: false

metaR r0558
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
product: MODEL1310110037#
reversible: true
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
type: Reaction

metaM CE4876 r
is: CHEBI:15748
initial amount: NaN
is: HMDB00127
is: SBO:0000247
has only substance units: false
name: delta12-Prostaglandin J2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaM 4abutn m
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01080
is: CHEBI:58264
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
name: 4-ammoniobutanal

metaR RE3326M
reversible: true
is described by: ECO:0000000
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
name: RE3326
type: Reaction
kinetic law: MODEL1310110037#

metaR r0618
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is: SBO:0000176
reactant: MODEL1310110037#
product: MODEL1310110037#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
reversible: true

metaM HC00591 m
has only substance units: false
type: Species
is: CHEBI:16769
constant: false
initial concentration: 1.0
name: 2-oxoglutaramate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false

metaR NDPK8
is described by: ECO:0000269
name: Nucleoside-diphosphate kinase (ATP:dADP)
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110037#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110037#
reversible: true
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_bdd97e7e_7133_4c29_a5da_c5bccbb6c2b9
is: Q8TF08
is: SBO:0000252
constant: false
is encoded by: hsa:170712
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: COX7B2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_7e155380_6b8d_4b66_809c_86405b0297ce
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:549
name: AUH
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: Q13825
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_70287628_91b9_4adb_8291_7b83a925d8b7
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7001
constant: false
initial amount: NaN
name: PRDX2
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_b7577da8_43ce_40db_af6b_8faef5287400
boundary condition: true
is: Q9UHW9
constant: false
has only substance units: false
initial amount: NaN
name: SLC12A6
is: SBO:0000252
type: Species
is encoded by: hsa:9990
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_4b222f34_6c06_4ec0_8b8b_69eb3887d101
type: Species
name: ACHE
initial concentration: NaN
is encoded by: hsa:43
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaR ADNt
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false
is described by: ECO:0000269
modifier: MODEL1310110037#
reversible: true
product: MODEL1310110037#
name: adenosine facilated transport in cytosol

metaR RTOTAL2t
type: Reaction
product: MODEL1310110037#
name: RTOTAL2 transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000000

metaR SPODM
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is described by: ECO:0000269
name: superoxide dismutase
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.15.1.1
type: Reaction
kinetic law: MODEL1310110037#
reversible: false
product: MODEL1310110037#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_2f464dd4_7c22_4f4d_9d99_e58dea4f5c65
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:1375
initial concentration: NaN
is: B7Z5T8
is: SBO:0000252
name: CPT1B
initial amount: NaN
type: Species

metaM leuktrB4 e
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: leukotriene B4(1-)
constant: false
is: HMDB01085

http://identifiers.org/biomodels.db/MODEL1310110037#_0aae232a_9582_4355_9149_4d0da6e248f6
is: SBO:0000252
initial concentration: NaN
name: _H45672_1_m
is encoded by: hsa:H45672
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaM arachd c
is: HMDB01043
has only substance units: false
initial amount: NaN
type: Species
name: arachidonate
is: CHEBI:32395
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
constant: false

metaR BILIRUBtr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000

metaM ppa m
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN
has only substance units: false
is: HMDB00237
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: propionate
is: CHEBI:17272
constant: false

metaR r0724
modifier: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
reversible: true
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#

metaR ACCOAtn
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110037#
name: acetyl-CoA transport, nuclear
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110037#_e8ba4341_be57_4fdc_b2fc_bec3913ef224
initial concentration: NaN
constant: false
is: P13686
boundary condition: true
name: ACP5
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:54
has only substance units: false

metaR RE0944E
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110037#
name: RE0944
type: Reaction
fast: false
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176

metaM asp L c
initial concentration: 1.0
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
initial amount: NaN
constant: false
is: HMDB00191
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:29991

metaR RE3006M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110037#
name: RE3006
modifier: MODEL1310110037#
reversible: true
product: MODEL1310110037#
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction

metaR SO4tl
product: MODEL1310110037#
name: Sulfate transport (lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110037#
is: SBO:0000185
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110037#

metaM pail hs c
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
constant: false
has only substance units: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial concentration: 1.0
is: CHEBI:57880

metaR r1365
is described by: ECO:0000000
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
name: Vesicular transport
reversible: false
reactant: MODEL1310110037#
fast: false
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_96099935_1d21_4cd9_b5a3_5c651fafebbc
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: SLC2A10
is encoded by: hsa:81031
boundary condition: true
is: O95528
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_a07a7e70_cc2b_44e3_b590_359fa2f006f3
constant: false
initial concentration: NaN
name: SLC12A7
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10723
type: Species
is: Q9Y666

metaR r1610
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_5b2246bb_131d_4ef2_a8c4_3cd0b7cbe5e9
initial amount: NaN
initial concentration: NaN
name: RDH5
is: Q92781
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:5959
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_2ff0002b_b17f_4985_9a3a_df595b7ae73a
name: COX5A
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:9377
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: P20674

http://identifiers.org/biomodels.db/MODEL1310110037#_9e799491_7fd2_4920_a17a_dc1540a6c94b
constant: false
name: GPX4
initial amount: NaN
boundary condition: true
is encoded by: hsa:2879
type: Species
has only substance units: false
initial concentration: NaN
is: P36969
is: SBO:0000252

metaM retinal c
has only substance units: false
is: CHEBI:15035
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: HMDB01358
boundary condition: false
name: retinal
type: Species
initial concentration: 1.0

metaR r0556
is: SBO:0000176
kinetic law: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.14.19.1
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
type: Reaction

metaR r2103
modifier: MODEL1310110037#
fast: false
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110037#

metaR r1799
modifier: MODEL1310110037#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
name: Y+LAT2 Utilized transport
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_8c994d38_f30a_44a9_929f_6041e1f8a94d
is: SBO:0000252
constant: false
is: P53794
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6526
name: SLC5A3
has only substance units: false
initial amount: NaN
type: Species

metaM HC01415 m
name: (2E)-Octenoyl-CoA
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
boundary condition: false
is: CHEBI:27537
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_f348ab5e_5530_4e25_be46_7177212c66a9
name: ACADM
is encoded by: hsa:34
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: P11310
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_71dc30ae_b4e6_4c4d_833d_a6eb5b1acd82
initial amount: NaN
is encoded by: hsa:5162
is: SBO:0000297
has part: P29803
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:1737
is encoded by: hsa:5161
name: DLAT:DLD:PDHA2:PDHB:PDHX
has part: Q86YI5
has part: P11177
boundary condition: true

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_a1bf90f5_9988_4577_89b7_1c33f0417451
is: SBO:0000252
is: P07954
boundary condition: true
name: FH
is encoded by: hsa:2271
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_a43bc56d_4f11_4744_b2b3_5ef88c0507c5
initial amount: NaN
is encoded by: hsa:80864
type: Species
has only substance units: false
is: Q99944
name: EGFL8
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM cholcoa c
has only substance units: false
is: SBO:0000247
is: HMDB01374
constant: false
name: choloyl-CoA(4-)
boundary condition: false
is: CHEBI:57373
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794

metaR r1611
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
type: Reaction
reversible: true
kinetic law: MODEL1310110037#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_483e71cd_40d7_4c8b_92dd_aea75f0be53b
is: Q9NTN3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SLC35D1
is encoded by: hsa:23169
boundary condition: true
type: Species
constant: false

metaM 4nph e
constant: false
name: 4-nitrophenolate
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01232
is: SBO:0000247
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: CHEBI:57917

http://identifiers.org/biomodels.db/MODEL1310110037#_32df237e_b7ea_43b3_87c7_603bc9cef5ca
name: SLC25A10
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1468
initial amount: NaN
is: Q9UBX3
boundary condition: true
has only substance units: false

metaR r0660
kinetic law: MODEL1310110037#
is: SBO:0000176
product: MODEL1310110037#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
modifier: MODEL1310110037#
type: Reaction

metaM q10h2 m
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
name: Ubiquinol-10
is: SBO:0000247
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
type: Species
initial amount: NaN

metaM taur x
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
is: SBO:0000247
is: CHEBI:15891
boundary condition: false
constant: false
name: taurine
is: HMDB00251
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

metaR r2104
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110037#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110037#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_9ac0006e_d800_4113_86a0_18fcbe6aef24
has only substance units: false
is: O00337
type: Species
initial amount: NaN
name: SLC28A1
is: SBO:0000252
is encoded by: hsa:9154
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_047002cf_c8d6_49b7_8191_a9ebce91951a
is: SBO:0000252
initial amount: NaN
name: SLC2A6
boundary condition: true
constant: false
is: Q9UGQ3
is encoded by: hsa:11182
has only substance units: false
initial concentration: NaN
type: Species

metaR ALAt2r
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
is: SBO:0000185
modifier: MODEL1310110037#
name: L-alanine reversible transport via proton symport
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
kinetic law: MODEL1310110037#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_18ef4826_3637_4cde_bc4a_3ba32a98fed9
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: COX2
constant: false
is: Q7GXZ8
initial concentration: NaN
is encoded by: hsa:4513
has only substance units: false

metaR GGH 10FTHF7GLUe
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000

metaM tsul c
name: thiosulfate(2-)
is: HMDB00257
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:16094
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
constant: false

metaR r0722
is: SBO:0000176
product: MODEL1310110037#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.3.12

http://identifiers.org/biomodels.db/MODEL1310110037#_d2049355_613c_4717_9697_6ebbf092a8ad
has only substance units: false
is encoded by: hsa:80308
type: Species
boundary condition: true
initial amount: NaN
name: FLAD1
constant: false
is: SBO:0000252
initial concentration: NaN

metaR GLYCK2
reactant: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR
reversible: false
type: Reaction
name: glycerate kinase
is: SBO:0000176
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_4cb88a13_d483_4174_8c93_25c9b68839cb
type: Species
constant: false
has only substance units: false
name: _J03866_1_m
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:J03866

http://identifiers.org/biomodels.db/MODEL1310110037#_5fdc9ac0_a95d_474d_b352_58a02efb2dbf
initial concentration: NaN
is encoded by: hsa:2687
is: SBO:0000252
name: GGT5
has only substance units: false
boundary condition: true
is: P36269
constant: false
initial amount: NaN
type: Species

metaR r1612
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
modifier: MODEL1310110037#

metaR RE1796M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.145
type: Reaction
product: MODEL1310110037#
reversible: true
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: RE1796
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_1383abe6_e9b2_4315_9ef9_9f709bcc2278
initial amount: NaN
initial concentration: NaN
is: Q9UN76
name: SLC6A14
is: SBO:0000252
is encoded by: hsa:11254
type: Species
boundary condition: true
has only substance units: false
constant: false

metaM nrpphr e
initial concentration: 1.0
initial amount: NaN
name: Norepinephrine
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:33569
has only substance units: false
constant: false
is: HMDB00216
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

metaR DM fol
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaM asp L e
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
name: L-aspartate(1-)
constant: false
is: HMDB00191
is: SBO:0000247
is: CHEBI:29991
boundary condition: false

metaR CRMPte
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
name: crmp hs transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
reversible: true

metaM pglyc hs c
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
name: pglyc_hs[c]
initial concentration: 1.0
is: SBO:0000247
is: HMDB00067
constant: false
notes: FORMULA: CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110037#_f4a30b9d_7a28_43df_8b1b_f40c904f56fa
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: Q9BY49
initial amount: NaN
is: SBO:0000252
name: PECR
is encoded by: hsa:55825
boundary condition: true

metaR r2101
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110037#

metaR RE3628M
fast: false
modifier: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110037#
reversible: true
type: Reaction
name: RE3628

metaM HC00342 c
is: CHEBI:16383
initial concentration: 1.0
name: cis-aconitate(3-)
type: Species
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417

metaR UMPK
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase
kinetic law: MODEL1310110037#
is: SBO:0000176
fast: false
is described by: ECO:0000269
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110037#
modifier: MODEL1310110037#

metaR GLCter
type: Reaction
product: MODEL1310110037#
reversible: true
fast: false
kinetic law: MODEL1310110037#
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185

metaM hdd2coa m
constant: false
is: C05272
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
initial amount: NaN
is: HMDB03945
boundary condition: false

metaR ITCOALm
reactant: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.5
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000212

http://identifiers.org/biomodels.db/MODEL1310110037#_716f6888_3415_4b67_b4d3_e7e4568809bc
has only substance units: false
initial concentration: NaN
is encoded by: hsa:NM 013421
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: _NM_013421_1_e

metaM bilirub r
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: bilirubin(2-)
is: HMDB00054
is: SBO:0000247
has only substance units: false

metaM i c
initial amount: NaN
is: SBO:0000247
is: CHEBI:16382
has only substance units: false
constant: false
name: iodide
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
initial concentration: 1.0
boundary condition: false
type: Species

metaR r1364
is: SBO:0000185
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
reversible: false

metaM i e
initial amount: NaN
name: iodide
is: CHEBI:16382
boundary condition: false
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
is: HMDB12238
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_62ff75a0_4fd0_402e_b8c2_e43f6fcc694d
is encoded by: hsa:5238
initial concentration: NaN
name: PGM3
boundary condition: true
is: SBO:0000252
type: Species
is: B4DX94
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_0f1f2ccf_67ec_4af9_b9e9_a7394bf03a1a
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:1375
name: CPT1B
is: SBO:0000252
is: E9PCP2
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_add5e793_00fb_4a02_9801_811300ad6882
initial amount: NaN
is encoded by: hsa:1375
constant: false
type: Species
is: Q53FV7
initial concentration: NaN
name: CPT1B
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR UMPK6n
reversible: true
is: SBO:0000176
name: UMP kinase (dCTP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#

metaM lys L x
initial amount: NaN
is: HMDB00182
name: L-lysinium(1+)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:32551
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_03c7c212_888e_48f7_a447_c9f7ef1cacd6
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4716
is: SBO:0000252
initial amount: NaN
name: NDUFB10
is: A8K761

metaR r2102
product: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110037#
reversible: true

metaR r0330
product: MODEL1310110037#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
type: Reaction
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000

metaR r0553
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
type: Reaction
is: SBO:0000176
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110037#

metaR r0720
product: MODEL1310110037#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
fast: false

MODEL1310110037#
species: metaM 2oxoadp m
species: metaM Rtotal e
species: metaM pi c
species: metaM pep c
stoichiometry: 0.385872
species: metaM HC01522 c
species: metaM hdd2coa m
species: metaM nadh m
species: metaM thbpt4acam c
species: metaM CE1926 e
species: metaM lnlccoa r
species: metaM glyc3p c
species: metaM cmp c
species: metaM co2 c
species: metaM fad c
species: metaM ach e
species: metaM lnlccoa m
species: metaM lnlncgcoa m
species: metaM accoa c
species: metaM HC02187 c
species: metaM 3dhguln c
species: metaM HC01104 e
species: metaM pa hs c
species: metaM pmtcrn x
species: metaM tcynt c
species: metaM pail hs n
species: metaM acgam l
species: metaM pe hs e
species: metaM duri c
species: metaM coa c
species: metaM orot e
species: metaM HC00319 c
species: metaM oh1 e
species: metaM HC02207 e
species: metaM xylu D c
species: metaM hgentis c
species: metaM HC00250 e
stoichiometry: 0.154463
species: metaM CE4792 m
species: metaM leuktrA4 e
species: metaM xol7a r
species: metaM ocdcea l
species: metaM arachcrn c
species: metaM ppcoa c
species: metaM crn c
species: metaM glx m
species: metaM ascb L c
species: metaM pmtcoa c
species: metaM pchol hs c
species: metaM cgly c
kind: SECOND
species: metaM HC02179 c
species: metaM adrn c
species: metaM h c
species: metaM val L m
species: metaM ps hs c
species: metaM thr L e
species: metaM pristcoa x
species: metaM mmcoa R m
species: metaM Sfglutth c
species: metaM dad 2 e
species: metaM asp L e
species: metaM ditp n
species: metaM HC01496 m
species: metaM dag hs c
species: metaM aacoa m
species: metaM ptrc e
species: metaM lys L c
species: metaM man1p c
species: metaM orn e
type: ModifierSpeciesReference
species: metaM acald m
species: metaM cala c
species: metaM HC00229 e
boundary condition: true
species: metaM adp n
species: metaM dutp m
species: metaM citr L e
species: metaM acnam n
species: metaM na1 e

http://identifiers.org/biomodels.db/MODEL1310110037#_e325bd42_3cb9_4cb2_90a3_7548274124da
boundary condition: true
is: Q99624
name: SLC38A3
is encoded by: hsa:10991
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252

metaM ile L e
boundary condition: false
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
name: L-isoleucine
type: Species
is: CHEBI:17191
is: HMDB00172
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_fbedd5ed_b796_4ab4_9905_b24998d66314
initial concentration: NaN
name: SLC23A2
type: Species
boundary condition: true
is encoded by: hsa:9962
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_d1581baa_f31c_4004_90d9_6efd46ff8b27
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: DPYSL3
is: Q8IXW6
has only substance units: false
is encoded by: hsa:1809

metaM nrpphr c
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:33569
name: Norepinephrine
boundary condition: false

metaR COAtr
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
fast: false
reversible: true
name: COA transporter, endoplasmic reticulum

metaR r1613
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3928a903_b13b_44af_99af_88d7c8ad7f3b
is: Q96KH8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6530
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SLC6A2
constant: false
type: Species

metaM tsul e
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial amount: NaN
is: CHEBI:16094
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: thiosulfate(2-)
is: HMDB00257
has only substance units: false

metaM thf c
is: CHEBI:57453
initial amount: NaN
is: C00101
type: Species
boundary condition: false
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_509dfd3e_d01f_4f13_9631_f1ad67e6b5c0
is: O75610
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: LEFTY1
constant: false
is encoded by: hsa:10637
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_dc9c6b4b_a73c_4566_ba13_4676b4b8352d
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: ALPI
is: SBO:0000252
is encoded by: hsa:248
constant: false
is: P09923
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_707dd5da_f96e_4a32_8dba_920a8f2e6fce
is encoded by: hsa:279
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: AMY2A
initial concentration: NaN
is: P04746

metaR r0339
is described by: ECO:0000000
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
modifier: MODEL1310110037#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaR 34DHPLACOX
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110037#
fast: false
type: Reaction
kinetic law: MODEL1310110037#
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
product: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_7996c0c3_1c59_4aea_9dc5_6a03f7ffe7f7
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51227
name: PIGP

metaR r0552
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
reversible: true
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8

metaM 4abutn c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
name: 4-Aminobutanal
is: HMDB01080
has only substance units: false
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: C00555

metaR r1596
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#

metaR FAOXC101C8m
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_36acbac0_548a_4505_a023_8bdb9fd14619
name: HGD
is: SBO:0000252
is encoded by: hsa:3081
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: Q93099

http://identifiers.org/biomodels.db/MODEL1310110037#_88bbc45d_bd11_42ec_b13f_e39d3686eddb
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3795
name: KHK
is: Q6IBK2

http://identifiers.org/biomodels.db/MODEL1310110037#_75439a77_20d6_4045_acf7_01cbe53639e7
boundary condition: true
initial concentration: NaN
is: P13196
has only substance units: false
name: ALAS1
is encoded by: hsa:211
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaR COAtp
is: SBO:0000185
product: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
name: coenzyme A transport, peroxisomal
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM but c
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: butyrate
is: CHEBI:17968
type: Species
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039

metaM glc D r
initial amount: NaN
is: CHEBI:4167
constant: false
has only substance units: false
is: HMDB00122
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: D-glucose
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaM CE2433 m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
is: CHEBI:57795
has only substance units: false
initial amount: NaN

metaM ile L c
name: L-isoleucine
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: HMDB00172
initial amount: NaN

metaR MGSA
fast: false
name: methylglyoxal synthase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
product: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
reversible: false
is: SBO:0000176
reactant: MODEL1310110037#
is described by: ECO:0000000

metaR r2330
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_f1502579_f2e8_41c3_8764_e4d5619e1439
is encoded by: hsa:5052
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
name: PRDX1
boundary condition: true

metaR H2MTer L
fast: false
kinetic law: MODEL1310110037#
name: H2 mannosyltransferase, endoplasmic reticulum
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
is: SBO:0000176
reversible: false
reactant: MODEL1310110037#
type: Reaction

metaR r1595
product: MODEL1310110037#
reversible: true
fast: false
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
is described by: ECO:0000000

metaR KHK
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
name: ketohexokinase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.3
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR r1177
is described by: ECO:0000000
product: MODEL1310110037#
name: EC:3.1.1.13
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
reversible: false

metaR BILDGLCURt
type: Reaction
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110037#
reversible: true
reactant: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
is: SBO:0000185
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_30dde518_538f_4443_8a7a_47d79b781772
is encoded by: hsa:2882
boundary condition: true
has only substance units: false
name: GPX7
is: Q96SL4
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_6d4ab5a6_330c_41b7_9d6c_9f075db0ce22
constant: false
name: OGDH
is encoded by: hsa:4967
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: B4E3E9
boundary condition: true
has only substance units: false

metaM hdcea r
is: CHEBI:32372
name: palmitoleate
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB03229
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

http://identifiers.org/biomodels.db/MODEL1310110037#_e3ed33ae_f435_4b64_a7e9_67af3dd10053
initial amount: NaN
is: SBO:0000252
name: NDUFS4
has only substance units: false
is: O43181
constant: false
initial concentration: NaN
is encoded by: hsa:4724
boundary condition: true
type: Species

metaM 4abutn e
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
boundary condition: false
is: CHEBI:58264
initial concentration: 1.0
name: 4-ammoniobutanal
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM arachdcrn m
initial concentration: 1.0
is: HMDB01322
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
has only substance units: false
initial amount: NaN
type: Species
name: C20:4 carnitine
is: CHEBI:57387

metaM 3hpcoa m
type: Species
name: 3-hydroxypropanoyl-CoA(4-)
is: HMDB06807
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58528

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaR GTHS
notes: GENE_ASSOCIATION: (2937.1) SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: glutathione synthetase
reversible: false
type: Reaction
modifier: MODEL1310110037#
is described by: ECO:0000269
fast: false
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.3.2.3
is: SBO:0000176

metaR r1594
reactant: MODEL1310110037#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
is: SBO:0000185
type: Reaction
product: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR PSP L
name: phosphoserine phosphatase (L-serine)
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
reversible: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.3.3

http://identifiers.org/biomodels.db/MODEL1310110037#_1342f299_8903_481a_9ed8_0262888d1009
has only substance units: false
is: B4DG68
type: Species
is encoded by: hsa:4842
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
name: NOS1

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

metaR COAtn
name: coenzyme A transport, nuclear
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110037#

metaR NADPHtru
reactant: MODEL1310110037#
name: NADPH transporter, endoplasmic reticulum
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110037#
reversible: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR TPI
reversible: true
reactant: MODEL1310110037#
name: triose-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.1
kinetic law: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is described by: ECO:0000134
product: MODEL1310110037#
type: Reaction

metaR RE1860E
notes: GENE_ASSOCIATION: (1267.1) SUBSYSTEM: Miscellaneous EC Number: 3.1.4.37 Confidence Level: 0 AUTHORS: PMID:12225906 NOTES:
type: Reaction
fast: false
name: RE1860
product: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.4.37
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true

metaR r1593
is: SBO:0000185
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_6b6f2060_a6e7_4720_8cff_50ec41f1440c
is: SBO:0000252
boundary condition: true
is encoded by: hsa:29920
initial concentration: NaN
has only substance units: false
name: PYCR2
constant: false
is: Q96C36
initial amount: NaN
type: Species

metaR EX 23cump LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2',3'-cyclic UMP(1-) exchange
type: Reaction

metaM 2mp2coa m
name: 2-Methylprop-2-enoyl-CoA
initial concentration: 1.0
type: Species
is: HMDB01011
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: CHEBI:27754
has only substance units: false
constant: false
boundary condition: false

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_19558090_10e9_4178_9d93_8ea0ad673416
is encoded by: hsa:26503
initial amount: NaN
name: SLC17A5
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9NRA2

http://identifiers.org/biomodels.db/MODEL1310110037#_f3f55033_b25c_4454_88fd_f14949e3aa46
type: Species
is: P08237
is: SBO:0000252
name: PFKM
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5213
boundary condition: true
initial amount: NaN

metaR PAFH
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.47
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
name: Platelet-activating factor acetylhydrolase
is described by: ECO:0000269

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_a45a4e8c_9b0f_4e23_b225_c5c1b976f824
initial concentration: NaN
is: Q7L266
is: SBO:0000252
constant: false
type: Species
name: ASRGL1
initial amount: NaN
is encoded by: hsa:80150
has only substance units: false
boundary condition: true

metaR r0616
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is: SBO:0000176
product: MODEL1310110037#
modifier: MODEL1310110037#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110037#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110037#

metaR TSTSTERONEt
is described by: ECO:0000269
product: MODEL1310110037#
fast: false
is: SBO:0000185
name: Testosterone transport
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:

metaM 5adtststerones e
initial amount: NaN
type: Species
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
boundary condition: false
has only substance units: false
is: HMDB06278
initial concentration: 1.0
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
constant: false

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_173796d8_398b_4569_9b4e_208da9e693e1
boundary condition: true
has only substance units: false
is: SBO:0000297
has part: Q9UHI5
is encoded by: hsa:23428
type: Species
constant: false
name: SLC7A8:SLC3A2
initial amount: NaN
initial concentration: NaN

metaR r0669
reversible: false
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
type: Reaction
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
is: SBO:0000176
fast: false

metaR COAtm
product: MODEL1310110037#
name: CoA transporter
type: Reaction
reactant: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is described by: ECO:0000269
modifier: MODEL1310110037#
reversible: true

metaM HC01610 e
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
initial amount: NaN
is: CHEBI:28607
name: CoproporphyrinogenI
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_a90d0b1d_e5d6_450b_9c84_04984e2c0718
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
name: UROD
is: SBO:0000252
is encoded by: hsa:7389
is: P06132
initial concentration: NaN

metaM glucys c
name: gamma-L-Glutamyl-L-cysteine
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H13N2O5S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00487 EHMN_ABBREVIATION: C00669
is: C00669
is: HMDB01049
type: Species
is: CHEBI:58173
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_124614d1_4434_4b5c_b5ee_ce6782ba7b0d
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:84532
name: ACSS1
initial concentration: NaN
has only substance units: false
is: Q9NUB1
boundary condition: true
initial amount: NaN

metaR r2333
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110037#
reversible: true
type: Reaction

metaM hom L e
initial concentration: 1.0
name: L-homoserine
is: HMDB00719
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
has only substance units: false

metaR r1592
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185

metaR MI1PP
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 1-phosphatase
reactant: MODEL1310110037#
is described by: ECO:0000269
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
product: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_1a301e03_af58_4d03_9b85_6da53ed8a571
is: Q5QPH3
initial amount: NaN
name: ACSS2
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:55902

http://identifiers.org/biomodels.db/MODEL1310110037#_3203998a_752a_48a7_97d5_0d15ea74c59c
boundary condition: true
is encoded by: hsa:2026
type: Species
is: P09104
constant: false
initial amount: NaN
initial concentration: NaN
name: ENO2
is: SBO:0000252
has only substance units: false

metaM phe L e
is: CHEBI:17295
initial amount: NaN
name: L-phenylalanine
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: HMDB00159
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
has only substance units: false

metaR r0668
is version of: http://identifiers.org/ec-code/2.4.2.19
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is: SBO:0000176
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_23574ec2_d2c3_434c_9e43_7f1ed021be96
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AV713053
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: _AV713053_1_m

metaR r2334
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM o2 x
name: O2
is: CHEBI:15379
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
is: HMDB01377
initial amount: NaN
type: Species
has only substance units: false
is: C00007
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_f267cb23_ce0f_4fdd_84eb_bed15680b778
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2877
is: P18283
name: GPX2
constant: false
type: Species

metaR r1591
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110037#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#

metaR r0614
type: Reaction
product: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110037#

metaR ILEt5m
is: SBO:0000185
name: Isoleucine mitochondrial transport
kinetic law: MODEL1310110037#
reversible: true
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110037#_a67e92f5_6aaa_430d_a24e_643bb36df7c9
is: SBO:0000252
initial concentration: NaN
is: Q1LZ56
has only substance units: false
is encoded by: hsa:206358
name: SLC36A1
constant: false
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_83d52735_0800_4f8b_886d_afe78cc5c5f0
boundary condition: true
initial concentration: NaN
type: Species
is: Q9UFY1
constant: false
name: PLCG1
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5335

metaM 5adtststerones c
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB06278
name: 5alpha-Dihydrotestosterone sulfate

metaM hLkynr c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17380
has only substance units: false
boundary condition: false
name: 3-hydroxy-L-kynurenine
type: Species
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
constant: false
is: HMDB11631
is: SBO:0000247

metaM crmp hs e
is: CHEBI:57674
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C18H35NO5PFULLRCO CHARGE: -2 EHMN_ABBREVIATION: C02960
name: ceramide 1-phosphate(2-)
type: Species

metaM bhb m
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:10983
constant: false
name: (R)-3-hydroxybutyrate
initial amount: NaN
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011

metaR CYTK4n
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,GTP),nuclear
fast: false
type: Reaction
reactant: MODEL1310110037#
reversible: true
is described by: ECO:0000269
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR DM atp c
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reversible: false
product: MODEL1310110037#
name: DM_atp(c)

metaM triodthy e
boundary condition: false
is: HMDB00265
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:18258
type: Species
has only substance units: false

metaM ru5p D c
type: Species
is: HMDB00618
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
name: D-ribulose 5-phosphate(2-)
is: CHEBI:58121
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

metaR PDHm
reversible: false
product: MODEL1310110037#
name: pyruvate dehydrogenase
reactant: MODEL1310110037#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.12
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.2.4.1
type: Reaction
is: SBO:0000176
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific

http://identifiers.org/biomodels.db/MODEL1310110037#_2553e65c_f120_4fe1_b053_ee09ebc3ca1f
is encoded by: hsa:11136
is: SBO:0000252
is: P82251
has only substance units: false
constant: false
name: SLC7A9
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR RE1898C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reversible: true
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: RE1898
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_3895f4b9_f9c6_490c_8aa2_8749dd7cdb86
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: HADHB
initial concentration: NaN
is encoded by: hsa:3032
is: P55084

http://identifiers.org/biomodels.db/MODEL1310110037#_8b90fdaa_363b_4d5e_a39d_e00bda6d18f2
type: Species
is: P14672
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: SLC2A4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6517

metaR r2331
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110037#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true

metaM ditp n
type: Species
is: HMDB03537
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:61382
constant: false
name: dITP(4-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345

metaM m3gacpail hs r
initial amount: NaN
is: SBO:0000247
is: CHEBI:16240
boundary condition: false
notes: FORMULA: C49H88NO29PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
type: Species
has only substance units: false
is: HMDB03125
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)
initial concentration: 1.0

metaM frdp x
constant: false
is: CHEBI:175763
is: HMDB00961
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: farnesyl pyrophosphate(3-)
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_4461c058_f71e_420a_8d29_b9334b569e41
initial amount: NaN
is: Q5JWV8
name: ACSL4
is: SBO:0000252
is encoded by: hsa:2182
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaR r1590
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_42e633b1_6dfd_4ed6_8dea_4942d1165ed9
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: E1CEI4
name: GCLC
is encoded by: hsa:2729

metaR KCC2t
reversible: true
is: SBO:0000185
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110037#
fast: false
product: MODEL1310110037#
name: K+-Cl- cotransporter (NH4+)
modifier: MODEL1310110037#
type: Reaction
is described by: ECO:0000269

metaM adp m
has only substance units: false
type: Species
constant: false
is: HMDB01341
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00008
name: ADP
is: http://identifiers.org/pubchem.compound/3310
is: SBO:0000247
is: CHEBI:456216

metaM but e
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
is: HMDB00039
type: Species
initial concentration: 1.0
is: CHEBI:17968
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: butyrate
boundary condition: false

metaM phe L c
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
name: L-phenylalanine
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00159
type: Species
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_9fe620c0_adda_4cde_8d44_693d122ae798
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: _R51273_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:R51273
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_82637a57_7e3a_4e78_b028_f903698ca26f
type: Species
is: SBO:0000252
constant: false
name: _AI761708_1_m
initial concentration: NaN
is encoded by: hsa:AI761708
boundary condition: true
has only substance units: false
initial amount: NaN

metaR GLUt7l
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110037#
name: Glutamate transport, lysosomal

metaR PPA
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110037#
name: inorganic diphosphatase
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_82580d8a_8656_41f4_95ff_8f29130fb413
is: SBO:0000252
is encoded by: hsa:5214
initial amount: NaN
constant: false
name: PFKP
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q5VSR7

metaR r0728
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_9d5a2d41_5874_423f_860b_a93f8154d4b4
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3284
is: P26439
is: SBO:0000252
constant: false
has only substance units: false
type: Species
name: HSD3B2

metaM fadh2 m
is: C01352
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197
name: Flavin adenine dinucleotide reduced
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:58307

metaR PEt
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: phosphatidylethanolamine transport
type: Reaction
product: MODEL1310110037#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_8583b8df_526a_45d7_b599_1f31f25392e0
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: HSD3B1
constant: false
is: P14060
is encoded by: hsa:3283
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_9b8f97ec_16d9_4b27_a124_868392ad9ca3
is: SBO:0000252
name: IDH1
initial concentration: NaN
is: O75874
is encoded by: hsa:3417
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_8a93ee67_5baf_4e78_bbd9_69c149a40140
type: Species
has only substance units: false
constant: false
is encoded by: hsa:10797
is: SBO:0000252
name: MTHFD2
is: P13995
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR HIStN1
reversible: true
name: Histidine transport (Na, H coupled)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185

metaM tsul m
initial amount: NaN
is: HMDB00257
type: Species
has only substance units: false
is: CHEBI:16094
initial concentration: 1.0
boundary condition: false
name: thiosulfate(2-)
constant: false
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320

metaR r2332
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110037#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaR r0443
type: Reaction
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110037#
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_b0906a45_86d1_4e87_b02d_76d7bd1b45b8
has only substance units: false
is: P00414
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4514
name: COX3
initial concentration: NaN
type: Species

metaM xan c
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00385
type: Species
constant: false
is: HMDB00292
name: Xanthine
is: CHEBI:17712
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_eb3bd5de_13b0_4461_882f_68b141d0d0a3
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: CPT1C
type: Species
is: Q8TCG5
is encoded by: hsa:126129
constant: false
boundary condition: true
initial concentration: NaN

metaR r2312
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_dde18b9a_5457_4388_bc27_2b7fc878ba18
is: Q96AT9
type: Species
initial concentration: NaN
is encoded by: hsa:6120
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: RPE
boundary condition: true

metaM 2mpdhl m
is: SBO:0000247
initial amount: NaN
name: S-(2-Methylpropanoyl)-dihydrolipoamide
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:17577
has only substance units: false
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
boundary condition: false

metaM f6p c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3385
initial amount: NaN
is: C00085
is: CHEBI:57579
has only substance units: false
is: HMDB00124
type: Species
constant: false
name: D-Fructose 6-phosphate
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_4bb0e81e_43d8_41ce_80e2_ba5393585b67
is encoded by: hsa:5048
initial amount: NaN
is: P43034
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: PAFAH1B1
has only substance units: false
boundary condition: true

metaR CYTK12n
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
name: cytidylate kinase (dCMP,dCTP),nuclear
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269

metaM acald m
name: acetaldehyde
has only substance units: false
is: HMDB00990
boundary condition: false
is: CHEBI:15343
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaR EX acmana LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-acetyl-D-mannosamine
type: Reaction

metaR TKT1
type: Reaction
name: transketolase
product: MODEL1310110037#
reversible: true
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is: SBO:0000176
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.2.1.1
reactant: MODEL1310110037#
is described by: ECO:0000000
fast: false

metaR DHPM1
is described by: ECO:0000269
modifier: MODEL1310110037#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
name: dihydropyrimidinase (5,6-dihydrouracil)
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.5.2.2

metaR FATP2t
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
reactant: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
name: fatty acid electroneutral transport
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000269

metaR r2311
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false

metaM HC01522 c
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:28508
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
name: Gentisate aldehyde
constant: false

metaR r1578
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_17fa21bd_821d_49ff_b0f2_482b2df51dd5
type: Species
is encoded by: hsa:6519
has only substance units: false
has part: P82251
is: SBO:0000297
boundary condition: true
has part: Q07837
initial concentration: NaN
constant: false
name: SLC7A9:SLC3A1
is encoded by: hsa:11136
initial amount: NaN

metaM HC01410 m
type: Species
is: CHEBI:28706
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial amount: NaN
has only substance units: false
name: (2E)-Hexenoyl-CoA
constant: false
boundary condition: false

metaR FADH2ETC
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110037#
type: Reaction
fast: false
name: Complex II reaction for respiratory chain

metaR DURAD2
name: dihydrothymin dehydrogenase (NADP)
modifier: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.1.2
product: MODEL1310110037#
is: SBO:0000176
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
fast: false

metaM didp n
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: HMDB03536
name: dIDP
has only substance units: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
is: CHEBI:28823

metaM citr L m
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: L-citrulline
is: CHEBI:16349
type: Species
is: HMDB00904

http://identifiers.org/biomodels.db/MODEL1310110037#_63166020_fd0c_4e63_88f3_f9be7b0db935
name: _H17063_1_m
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:H17063
constant: false
initial concentration: NaN
type: Species

metaR ARABR
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
is: SBO:0000176
name: arabinose reductase
reversible: false
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110037#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:

metaM ps hs c
initial amount: NaN
constant: false
is: HMDB00067
has only substance units: false
is: SBO:0000247
name: ps_hs[c]
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: CHARGE: 0

metaM o2s x
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
name: superoxide
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: HMDB02168
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_d8ce8f69_02fb_45e9_9fb9_7b31dcf50e0d
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6718
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: P51857
boundary condition: true
name: AKR1D1

metaR r1008
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
name: Facilitated diffusion

metaR 2OXOADOXm
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
product: MODEL1310110037#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/2.3.1.61
fast: false
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110037#
reactant: MODEL1310110037#

metaM acgpail hs c
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57265
has only substance units: false
initial amount: NaN

metaR FBA2
is version of: http://identifiers.org/ec-code/4.1.2.13
type: Reaction
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110037#
product: MODEL1310110037#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
modifier: MODEL1310110037#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD

metaR CYTK1
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is described by: ECO:0000269
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
name: cytidylate kinase (CMP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_0d902b65_bbb4_46ea_8803_eebbef73c19d
constant: false
type: Species
is: Q96CA6
has only substance units: false
is encoded by: hsa:30
boundary condition: true
name: ACAA1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r2314
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110037#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_2a2c1718_2396_4fe8_a874_d75e1bfd64c3
initial concentration: NaN
type: Species
name: ALPPL2
is: SBO:0000252
is: P10696
initial amount: NaN
is encoded by: hsa:251
constant: false
boundary condition: true
has only substance units: false

metaR r1579
fast: false
reversible: true
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GLYt7 211 r
is: SBO:0000185
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
name: glycine reversible transport via sodium and chloride symport (2:1:1)
type: Reaction
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
is described by: ECO:0000269

metaR RE1810M
fast: false
reactant: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
name: RE1810
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
is: SBO:0000176
reversible: true

metaR RE1534M
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
name: RE1534
kinetic law: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000000

metaM HC02179 c
has only substance units: false
is: CHEBI:34306
constant: false
type: Species
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_8863c9b8_2e19_4652_b2c9_864e56d9cf36
constant: false
name: NME1:NME2
has only substance units: false
initial concentration: NaN
is: SBO:0000297
type: Species
is encoded by: hsa:4830
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_1858c7f5_c1a6_4d2e_91e2_8873000b86b4
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3612
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: B7Z6Q4
initial amount: NaN
name: IMPA1

metaR GTHPm
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
fast: false
reactant: MODEL1310110037#
type: Reaction
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.12
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_96c265a0_5c1c_4da6_a5a6_fe1d021f48c1
name: SGPL1
has only substance units: false
boundary condition: true
initial amount: NaN
is: O95470
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:8879

http://identifiers.org/biomodels.db/MODEL1310110037#_8159e29c_107d_49cf_9ba9_b141d697b981
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM 2hb c
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial amount: NaN
is: HMDB00008
is: CHEBI:1148
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
name: 2-Hydroxybutyrate
type: Species

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_60c5e8ee_6e2d_429e_b0f4_0a2c313579c7
has only substance units: false
constant: false
is: Q8NEM3
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC16A7
initial concentration: NaN
is encoded by: hsa:9194
type: Species

metaR G5SADrm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
fast: false
product: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is: SBO:0000176
reactant: MODEL1310110037#
reversible: true

metaM ocdcea c
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
is: CHEBI:0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00207
name: octadecenoate (n-C18:1)
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_179a0a55_a640_47da_9df2_66d806bd67a5
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI222095
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: _AI222095_1_e

metaR H7ET2er
kinetic law: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
reversible: false
is: SBO:0000176
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.1

metaM itacon m
type: Species
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
boundary condition: false
is: HMDB02092
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17240
name: itaconate(2-)

metaM acgam6p c
is: CHEBI:57513
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: SBO:0000247
type: Species
is: HMDB01062
initial concentration: 1.0
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial amount: NaN
has only substance units: false
boundary condition: false

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM retn c
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
type: Species
is: CHEBI:35291
name: all-trans-retinoate
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01852
has only substance units: false
initial concentration: 1.0
constant: false

metaM dlnlcgcoa r
is: C03595
is: CHEBI:27979
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
is: SBO:0000247

metaR r2313
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_7eee61c6_2c5c_4629_8e30_b5f6184f1ac4
initial amount: NaN
constant: false
boundary condition: true
name: PLCB1
type: Species
initial concentration: NaN
is encoded by: hsa:23236
has only substance units: false
is: SBO:0000252

metaM lys L m
constant: false
name: L-lysinium(1+)
is: CHEBI:32551
type: Species
is: HMDB00182
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM ocdcea e
is: SBO:0000247
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
boundary condition: false
is: CHEBI:0
is: C00712
is: HMDB00207
initial amount: NaN
name: octadecenoate (n-C18:1)

http://identifiers.org/biomodels.db/MODEL1310110037#_c3422cdd_8851_4602_9f10_0f2a3d3c28d9
has only substance units: false
is: Q5JT09
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:83549
type: Species
name: UCK1
initial concentration: NaN
boundary condition: true
constant: false

metaR TKT2
modifier: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.1
name: transketolase
reversible: true
reactant: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
fast: false

metaM asn L m
has only substance units: false
is: HMDB00168
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
name: L-asparagine
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_ad951b9a_022a_44be_acd0_8e93d8545b45
has only substance units: false
constant: false
initial concentration: NaN
is: Q86XP1
name: DGKH
initial amount: NaN
boundary condition: true
is encoded by: hsa:160851
type: Species
is: SBO:0000252

metaR FBA4
modifier: MODEL1310110037#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.13
is described by: ECO:0000269
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110037#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase

metaR PPAm
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
name: inorganic diphosphatase
is described by: ECO:0000269
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_f61c12d4_331f_4b96_a06d_e1ff7c94b813
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI915649_1_c
boundary condition: true
constant: false
is encoded by: hsa:AI915649
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_601e6d83_998d_44da_92f3_1ac3f9c89d00
is: SBO:0000252
boundary condition: true
name: SLC2A13
type: Species
has only substance units: false
is encoded by: hsa:114134
initial amount: NaN
constant: false
initial concentration: NaN
is: Q96QE2

metaM glc D c
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00122
constant: false
is: CHEBI:4167
name: D-glucose
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0

metaR r1573
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM mmcoa R m
has only substance units: false
is: CHEBI:57326
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
initial amount: NaN
is: SBO:0000247
name: (R)-methylmalonyl-CoA(5-)
is: HMDB01269
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_a4bd87cb_1b0d_45be_9832_40b8a2832578
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: O75874
is: SBO:0000252
name: IDH1
initial amount: NaN
is encoded by: hsa:3417

metaR r2316
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110037#
reversible: true
is described by: ECO:0000000

metaM HC02210 c
has only substance units: false
is: CHEBI:34939
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: prostaglandin-d3
type: Species
constant: false
initial amount: NaN

metaM HC01231 c
has only substance units: false
is: CHEBI:58480
type: Species
initial concentration: 1.0
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate

metaM retinal cis 9 c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17898
name: all-trans-retinal
constant: false
is: HMDB01358
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575

metaR CYTK4
reversible: true
is described by: ECO:0000269
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: cytidylate kinase (dCMP)(GTP)
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
modifier: MODEL1310110037#
fast: false
type: Reaction

metaR ALCD21 D
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110037#
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.99.24
reversible: false
fast: false
name: alcohol dehydrogenase (D-1,2-propanediol)

metaR NADtx
reactant: MODEL1310110037#
type: Reaction
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
name: transport of NAD into peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110037#_7b42da10_e0b4_4b15_b360_88c465c1c6a5
has part: Q15102
boundary condition: true
type: Species
is: SBO:0000297
is encoded by: hsa:5050
has part: A8DPS7
name: PAFAH1B2:PAFAH1B3
initial amount: NaN
is encoded by: hsa:5049
initial concentration: NaN
constant: false
has only substance units: false

metaM mthgxl c
constant: false
type: Species
is: CHEBI:17158
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01167
name: methylglyoxal
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial amount: NaN
boundary condition: false

metaM 2hb e
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 2-Hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: HMDB00008
boundary condition: false
is: CHEBI:1148
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_cc6e35e4_e665_4761_bc67_1dca03543170
is: SBO:0000252
is encoded by: hsa:AI684467
initial amount: NaN
initial concentration: NaN
type: Species
name: _AI684467_1_m
constant: false
has only substance units: false
boundary condition: true

metaR ASPDt6
fast: false
name: D-aspartate transport via Na, H symport and K antiport
type: Reaction
reactant: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
product: MODEL1310110037#
is: SBO:0000185

metaR O2tn
name: O2 nuclear transport
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110037#
type: Reaction
reversible: true
is described by: ECO:0000000

metaR MGCHrm
modifier: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial

metaM nad c
has only substance units: false
type: Species
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide
is: HMDB00902
is: CHEBI:57540
initial amount: NaN
is: SBO:0000247
is: C00003
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_57e7b3d2_1b71_48fa_8ec1_f2bebb7c7d56
is encoded by: hsa:229
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P05062
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
name: ALDOB

metaR r1574
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000

metaR r2315
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
product: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR CYTK6
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
product: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
modifier: MODEL1310110037#
reversible: true
name: cytidylate kinase (CMP,CTP)

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM retn e
type: Species
initial concentration: 1.0
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
name: all-trans-retinoate
is: SBO:0000247
constant: false
is: HMDB01852
boundary condition: false
has only substance units: false

metaR CYTK5
fast: false
is: SBO:0000176
modifier: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
name: cytidylate kinase (dCMP)
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaM pail5p hs n
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
is: CHEBI:57795
type: Species
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
boundary condition: false
has only substance units: false

metaR KYNAKGAT
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110037#
is: SBO:0000176
name: L-Kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000269

metaR GGH 10FTHF5GLUl
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false
reactant: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF5GLU), lysosomal
is: SBO:0000176

metaM succ c
initial concentration: 1.0
has only substance units: false
name: Succinate
is: SBO:0000247
is: HMDB00254
is: C00042
is: CHEBI:30031
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_21513a8f_a61d_479e_aeda_7ab6fe153402
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3948
type: Species
name: LDHC
initial amount: NaN
is: P07864
initial concentration: NaN

metaR SO4t4 2
name: sulfate transport via sodium symport
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110037#
fast: false
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
is described by: ECO:0000269

metaM gchola c
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
type: Species
initial concentration: 1.0
name: glycocholate
is: HMDB00138
initial amount: NaN
is: CHEBI:58235
constant: false
has only substance units: false

metaM bhb e
is: SBO:0000247
is: CHEBI:10983
initial amount: NaN
has only substance units: false
is: HMDB00011
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
constant: false
initial concentration: 1.0
boundary condition: false
name: (R)-3-hydroxybutyrate

http://identifiers.org/biomodels.db/MODEL1310110037#_3b93bb51_ff9a_4a65_9087_17d7b2ccd44f
is: SBO:0000252
name: STS
is: P08842
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:412
initial concentration: NaN
type: Species

metaR PROSTGE1t
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110037#
fast: false
is: SBO:0000185
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_3a6e5a7a_cb2f_4050_a978_75d9c69902b1
constant: false
type: Species
initial concentration: NaN
name: PDHA1
is: P08559
is encoded by: hsa:5160
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM g6p c
initial amount: NaN
has only substance units: false
is: CHEBI:61548
is: SBO:0000247
is: HMDB01401
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
boundary condition: false
is: C00092
type: Species
name: D-Glucose 6-phosphate
initial concentration: 1.0
constant: false

metaR ANTHte
reactant: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000134
name: Transport of anthranilate
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM ppi c
constant: false
notes: FORMULA: HO7P2 CHARGE: -3
is: CHEBI:0
is: C00013
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: Diphosphate
is: HMDB00250
initial concentration: 1.0
boundary condition: false
type: Species

metaR r0224
type: Reaction
modifier: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
product: MODEL1310110037#

metaR RE1527M
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
name: RE1527
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_9262eef8_040d_4c07_926d_f3b8bcdca2b4
is encoded by: hsa:64078
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9HAS3
boundary condition: true
name: SLC28A3
is: SBO:0000252

metaR r1575
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction

metaM HC02210 e
type: Species
boundary condition: false
name: prostaglandin-d3
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
constant: false
is: CHEBI:34939

metaM glc D e
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00122
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:4167
name: D-glucose
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaR FAOXC183806m
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110037#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110037#
type: Reaction
product: MODEL1310110037#

metaR RE3565C
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
name: RE3565
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaR CBR2
modifier: MODEL1310110037#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.189
product: MODEL1310110037#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Carbonyl reductase [NADPH] 1
is: SBO:0000176
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ

metaR r2318
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110037#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_4813b81b_c000_4717_bc8c_78f1023f13a3
is: P36957
name: DLST
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:1743
initial amount: NaN
has only substance units: false
type: Species

metaR CYTK2
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
modifier: MODEL1310110037#
reactant: MODEL1310110037#
name: cytidylate kinase (dCMP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_6d8ef5dc_8a95_404a_a028_29f216558386
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: FAH
is: P16930
is encoded by: hsa:2184
type: Species
initial concentration: NaN

metaM leuktrF4 c
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4
is: CHEBI:27491
is: HMDB06465
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3022691e_0fe2_4422_9344_bb450b67c1a1
initial concentration: NaN
boundary condition: true
type: Species
name: SLC20A2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6575
constant: false
initial amount: NaN
is: B2RBR4

metaM pa hs n
is: CHEBI:57739
constant: false
is: SBO:0000247
name: phosphatidate(2-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_d293c7f6_e30f_4435_bacd_28f78f9076a0
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5297
is: B4DYG5
type: Species
has only substance units: false
name: PI4KA
boundary condition: true
initial concentration: NaN
constant: false

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR GAL3ST11
is version of: http://identifiers.org/ec-code/2.8.2.11
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
name: Galactosylceramide sulfotransferase
product: MODEL1310110037#
reversible: false
is: SBO:0000176

metaR PPCOAOm
modifier: MODEL1310110037#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000269
fast: false

metaR r1576
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_0325a685_f809_4880_8835_9718b802ebed
name: _AA177072_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:AA177072
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_1ff1ece2_9378_4815_82a4_f2eee482b2c1
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: D3DTL2
constant: false
name: ENO3
initial concentration: NaN
is encoded by: hsa:2027

metaR LNLNCAt
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110037#
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaR CYTK3
modifier: MODEL1310110037#
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (CMP)(GTP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
reactant: MODEL1310110037#

metaR r2317
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110037#
fast: false
type: Reaction

metaM ppi e
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00250
is: C00013
has only substance units: false
name: Diphosphate
is: CHEBI:33019
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaR PYK
reactant: MODEL1310110037#
is described by: ECO:0000134
product: MODEL1310110037#
is: SBO:0000176
name: pyruvate kinase
kinetic law: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false

metaR O2tm
name: O2 transport (diffusion)
fast: false
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
type: Reaction
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaM bhb c
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00011
has only substance units: false
initial concentration: 1.0
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species

metaM pa hs m
name: phosphatidate(2-)
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial amount: NaN
type: Species
is: CHEBI:57739

metaM dhcholestancoa x
is: CHEBI:15494
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial amount: NaN
is: HMDB02159
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_739229b1_7cba_4bda_9401_b61c4cf2da3c
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q15125
type: Species
is encoded by: hsa:10682
name: EBP

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR r1605
is: SBO:0000185
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaR RE1796R
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
reversible: true
product: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: RE1796
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#

metaR ECOAH9m
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110037#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110037#

metaR r0113
is described by: ECO:0000000
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
reversible: false
product: MODEL1310110037#

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM acald e
is: HMDB00990
name: acetaldehyde
type: Species
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
initial concentration: 1.0
initial amount: NaN

metaR PI4PLCn
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
type: Reaction
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
product: MODEL1310110037#
modifier: MODEL1310110037#
reversible: false

metaR r2106
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110037#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_c6ba28bf_6ea1_4ffc_abf1_b93296effb34
initial concentration: NaN
is encoded by: hsa:226
has only substance units: false
boundary condition: true
type: Species
name: ALDOA
constant: false
is: P04075
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_2a979e2f_ac57_4ad7_a484_727ae52e6a71
type: Species
initial concentration: NaN
is encoded by: hsa:224
is: P51648
boundary condition: true
constant: false
name: ALDH3A2
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r0962
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
name: Facilitated diffusion
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
product: MODEL1310110037#
is: SBO:0000185

metaR r2319
type: Reaction
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r1604
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
type: Reaction
is described by: ECO:0000000

metaM lys L c
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00182
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
is: CHEBI:32551
name: L-lysinium(1+)
is: SBO:0000247
initial concentration: 1.0

metaM ump c
is: CHEBI:57865
constant: false
is: HMDB00288
name: UMP
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
is: C00105
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_e8e14948_962b_4122_bef2_890ce1a02761
is: SBO:0000252
is encoded by: hsa:728226
initial amount: NaN
boundary condition: true
name: _728226_1_m
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaR DOLPMT4 Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is: SBO:0000185
fast: false
product: MODEL1310110037#

metaR r1683
reversible: false
is: SBO:0000185
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Y+LAT2 Utilized transport
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110037#
fast: false

metaM ppa c
name: propionate
is: CHEBI:17272
constant: false
type: Species
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN
has only substance units: false
is: HMDB00237
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_bba5a944_655d_4bc8_8094_d473ded3caea
name: PLCZ1
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: Q86YW0
is: SBO:0000252
is encoded by: hsa:89869
initial amount: NaN
has only substance units: false

metaM ahcys m
boundary condition: false
initial amount: NaN
has only substance units: false
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
is: C00021
is: CHEBI:16680
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

metaM adp x
is: HMDB01341
is: SBO:0000247
name: ADP(3-)
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaR r0817
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110037#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM citr L e
is: SBO:0000247
type: Species
is: HMDB00904
is: CHEBI:16349
constant: false
initial amount: NaN
initial concentration: 1.0
name: citr_L[e]
has only substance units: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false

metaR RE2954C
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
reactant: MODEL1310110037#
name: RE2954
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
type: Reaction
product: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
is described by: ECO:0000000

metaR ABTD
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000176
fast: false
name: L-arabinitol 4-dehydrogenase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_9bcdc602_d9b4_49cc_ac7f_db8791d4b333
name: NDUFA7
is encoded by: hsa:4701
type: Species
is: Q6FG42
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r2105
modifier: MODEL1310110037#
reversible: true
product: MODEL1310110037#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_4806ac39_5316_4948_b40a_8adaa4e73014
name: TALDO1
has only substance units: false
is encoded by: hsa:6888
initial concentration: NaN
is: P37837
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_545d17a8_d17b_47d9_8c05_29af34337090
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4832
initial amount: NaN
boundary condition: true
constant: false
name: NME3
is: Q13232
type: Species
initial concentration: NaN

metaR r2108
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_e9b14fca_664e_4318_baf7_4428e8bebf79
boundary condition: true
is encoded by: hsa:6515
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P11169
name: SLC2A3

metaR BDHm
type: Reaction
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.30
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_d2234305_40c9_4e7c_bffe_e38b74ecc201
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:5315
name: PKM2
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P14618

metaR r1603
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
kinetic law: MODEL1310110037#
type: Reaction
is described by: ECO:0000000

metaR r0963
kinetic law: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is: SBO:0000185
reversible: false
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_d8616be5_fe22_4b2f_ba6f_76b8ff8b5528
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9Y617
constant: false
name: PSAT1
has only substance units: false
is encoded by: hsa:29968
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_86226441_cdb8_42ec_bde6_0c009c8aede9
initial concentration: NaN
is: P34949
is encoded by: hsa:4351
constant: false
has only substance units: false
name: MPI
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

metaR DNDPt16m
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUDP transport via dADP antiport
modifier: MODEL1310110037#
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
reversible: false

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM dhcholestanate c
initial concentration: 1.0
is: HMDB00359
constant: false
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

metaM acald c
initial amount: NaN
is: HMDB00990
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
initial concentration: 1.0
name: acetaldehyde

metaR r2058
reactant: MODEL1310110037#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reversible: false
is described by: ECO:0000000
product: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_de97b2a7_f627_459b_ae8c_7cda0abb339e
initial amount: NaN
is: P00325
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:125
type: Species
name: ADH1B
initial concentration: NaN

metaR PPD2CSPp
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
product: MODEL1310110037#
is: SBO:0000176
kinetic law: MODEL1310110037#
reversible: false
name: PPD2CSPp
reactant: MODEL1310110037#

metaR DCTPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
product: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: dCTP diffusion in nucleus
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false

metaR RE1342C
is: SBO:0000176
kinetic law: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
name: RE1342
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
is described by: ECO:0000000
product: MODEL1310110037#

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_35967955_7666_48b4_925b_1496008bc88b
name: BAAT
is encoded by: hsa:570
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q14032

metaM HC00342 m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
name: cis-aconitate(3-)
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16383
initial amount: NaN
constant: false

metaM lys L e
initial amount: NaN
is: HMDB00182
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
initial concentration: 1.0
type: Species

metaR r1602
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true

metaM asn L e
boundary condition: false
is: SBO:0000247
is: CHEBI:17196
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00168
name: L-asparagine
initial amount: NaN
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

metaR MI1P Dtn
name: inositol 1-phosphate nuclear transport (diffusion)
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#

metaR DOLPMT3 Ler
reactant: MODEL1310110037#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.260
reversible: false
product: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#

metaM citr L c
is: SBO:0000247
type: Species
is: HMDB00904
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: L-citrulline
boundary condition: false

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM ump e
boundary condition: false
is: HMDB00288
is: SBO:0000247
constant: false
name: UMP(2-)
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
is: CHEBI:57865
initial concentration: 1.0

metaM ppa e
initial amount: NaN
is: CHEBI:17272
name: propionate
is: HMDB00237
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_b286a391_bad2_4a77_be57_dc66f677d100
type: Species
initial concentration: NaN
constant: false
name: PEMT
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10400
boundary condition: true

metaR r2107
reversible: true
is described by: ECO:0000000
product: MODEL1310110037#
modifier: MODEL1310110037#
fast: false
type: Reaction
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR BAMPPALDOX
is: SBO:0000176
fast: false
reactant: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000212
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_7cfeb2d7_48e4_4fd3_b5fe_281953000599
initial concentration: NaN
constant: false
name: _AI539321_1_c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI539321
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_a23233e0_e6bb_4633_83ae_224976a8f049
constant: false
initial concentration: NaN
type: Species
name: _LOC374569_1_e
initial amount: NaN
is encoded by: hsa:LOC374569
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM nmn c
boundary condition: false
is: HMDB00229
name: NMN
constant: false
initial concentration: 1.0
is: C00455
has only substance units: false
is: CHEBI:14649
initial amount: NaN
type: Species
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: SBO:0000247

metaR MECOAS1m
name: mesaconate--CoA ligase (GDP-forming)
product: MODEL1310110037#
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is: SBO:0000176
reactant: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR ECOAH1m
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
modifier: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.18
reversible: true
fast: false
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is described by: ECO:0000304

metaR r0752
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:

metaM icit c
initial amount: NaN
is: CHEBI:16087
initial concentration: 1.0
is: C00311
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: SBO:0000247
name: Isocitrate
type: Species
constant: false
has only substance units: false
is: HMDB00193
boundary condition: false

metaR SERGLYexR
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#
name: L-Serine/Glycine reversible exchange
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false

metaR RE2660C
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110037#
fast: false
name: RE2660
kinetic law: MODEL1310110037#
product: MODEL1310110037#

metaR r1609
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM ppi n
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: diphosphate(3-)
is: SBO:0000247
is: CHEBI:33019
has only substance units: false
type: Species
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110037#_49071607_1d4c_491c_8545_92a33de737c4
initial concentration: NaN
constant: false
is: SBO:0000297
has only substance units: false
has part: E5KS60
is encoded by: hsa:8803
name: SUCLG1:SUCLA2
boundary condition: true
initial amount: NaN
type: Species

metaR FPGS8m
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/6.3.2.17
reversible: false
modifier: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
fast: false
is described by: ECO:0000000
name: folylpolyglutamate synthetase (10fthf), mitochondrial
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_171cd18e_c986_4b82_82d3_bf4c1817bb9c
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: P17568
constant: false
boundary condition: true
is encoded by: hsa:4713
is: SBO:0000252
name: NDUFB7

metaR r0812
type: Reaction
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110037#
product: MODEL1310110037#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_a5a5e835_e240_498d_97c2_c1663f8c2053
has only substance units: false
name: ACP2
constant: false
is encoded by: hsa:53
is: E9PCI1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaM asn L c
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00168
is: CHEBI:17196
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine

http://identifiers.org/biomodels.db/MODEL1310110037#_ea8f9956_9b9b_4dde_805a_557ca8ea757c
is: P13929
name: ENO3
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:2027

metaR GLYOX
fast: false
name: hydroxyacylglutathione hydrolase
is version of: http://identifiers.org/ec-code/3.1.2.6
reversible: false
product: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#

metaR r1608
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110037#
fast: false
reversible: true
reactant: MODEL1310110037#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_5dd5b4c0_7ffc_4a22_8598_a669f219c92c
boundary condition: true
type: Species
constant: false
has only substance units: false
name: TKTL1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8277
is: B7Z7I0

metaR r2109
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
type: Reaction
is: SBO:0000185
reversible: true
modifier: MODEL1310110037#
fast: false

metaM pi x
constant: false
name: hydrogenphosphate
is: HMDB00973
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:43474

metaR RE1691M
fast: false
modifier: MODEL1310110037#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
is version of: http://identifiers.org/ec-code/2.8.1.1
name: RE1691
product: MODEL1310110037#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_cc658299_a234_4a5f_b8a4_164e0c4af771
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:LOC727762
constant: false
name: _LOC727762_1_m
initial concentration: NaN
type: Species

metaR RE2999M
reversible: true
name: RE2999
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
modifier: MODEL1310110037#
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000000

metaR NDPK4n
modifier: MODEL1310110037#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
reactant: MODEL1310110037#
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
product: MODEL1310110037#

metaR HAtly
kinetic law: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: hyaluronan transport, extracellular to lysosome
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110037#
product: MODEL1310110037#

metaR r1607
product: MODEL1310110037#
reactant: MODEL1310110037#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false

metaR CDSm
product: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
modifier: MODEL1310110037#
is described by: ECO:0000000
name: phosphatidate cytidylyltransferase
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.41
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_4ceb1e34_a83a_42dd_a21c_370097255d72
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: _BE966236_1_m
is encoded by: hsa:BE966236
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_40c17879_58b0_4b98_ac0e_fa1940b4f2d0
name: CHAT
has only substance units: false
is encoded by: hsa:1103
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is: D3DX95
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_d8167950_1e38_4ded_bce3_6ab65a8ce108
is encoded by: hsa:222
name: ALDH3B2
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P48448
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110037#_bddb54ba_0f68_4b01_89a5_37a9193d4fe6
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AI656480
name: _AI656480_1_m
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_058a4824_aebe_48f3_979c_57cc3a769d5c
initial amount: NaN
is: Q7GXY8
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:4512
name: COX1

http://identifiers.org/biomodels.db/MODEL1310110037#_66a475c7_de6d_463b_901c_4b3787d6dc93
is: SBO:0000252
name: SLC6A8
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6535
is: B4DIA3
type: Species
constant: false
boundary condition: true

metaM 2maacoa m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 2-methylacetoacetyl-CoA(4-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
type: Species
constant: false
is: CHEBI:57335
is: HMDB01157

http://identifiers.org/biomodels.db/MODEL1310110037#_829849f9_8d8a_4151_b5b7_f67ccc430980
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:229
is: P05062
name: ALDOB
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_ae4518db_35ed_44f1_bc44_8fb331afeb4a
initial amount: NaN
boundary condition: true
is encoded by: hsa:4967
name: OGDH
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: Q02218

metaM HC01231 m
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
is: CHEBI:58480

http://identifiers.org/biomodels.db/MODEL1310110037#_bdc8095a_563f_48c7_8c51_79a4ab76a2f3
has only substance units: false
boundary condition: true
name: HADHB
is: SBO:0000252
initial amount: NaN
constant: false
is: P55084
type: Species
is encoded by: hsa:3032
initial concentration: NaN

metaM arachdcrn x
is: http://identifiers.org/pubchem.compound/5462164
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: C20:4 carnitine
is: HMDB01064
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236

metaM ppi m
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false
is: CHEBI:33019
initial concentration: 1.0
is: SBO:0000247
name: Diphosphate
type: Species
boundary condition: false
is: HMDB00250
constant: false
is: C00013
initial amount: NaN

metaR r1606
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110037#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_c7be8915_2f56_42bb_875c_7917235d39a0
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is: Q92820
name: GGH
initial concentration: NaN
is encoded by: hsa:8836
initial amount: NaN
has only substance units: false

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_198bb901_63fd_46e7_9776_9c8124d73995
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:151531
has only substance units: false
initial concentration: NaN
type: Species
is: O95045
name: UPP2

metaR r0753
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is described by: ECO:0000000
fast: false
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: SBO:0000176
reactant: MODEL1310110037#

metaM trdox c
type: Species
initial concentration: 1.0
is: CHEBI:18191
has only substance units: false
name: Oxidized thioredoxin
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_4d792fb9_6247_48b3_9c44_3473bb707708
constant: false
is: P11177
is: SBO:0000252
type: Species
initial amount: NaN
name: PDHB
is encoded by: hsa:5162
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR ARSA
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.6.8
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
product: MODEL1310110037#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110037#
reactant: MODEL1310110037#
name: Arylsulfatase A

metaM adrncoa c
type: Species
initial amount: NaN
is: C16170
boundary condition: false
is: SBO:0000247
name: adrenyl coenzyme A
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
constant: false
is: http://identifiers.org/pubchem.compound/47205480

metaR DNDPt28m
product: MODEL1310110037#
is: SBO:0000185
reactant: MODEL1310110037#
type: Reaction
reversible: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
name: dCDP transport via dGDP antiport
fast: false

metaR r2055
modifier: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaM acgam1p c
type: Species
constant: false
has only substance units: false
is: CHEBI:7125
name: N-Acetyl-D-glucosamine 1-phosphate
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
initial concentration: 1.0
is: HMDB01367
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r0968
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Postulated transport reaction
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_d0fe927c_8305_41a8_84d0_e9581f21d745
has only substance units: false
is: SBO:0000252
type: Species
name: MLYCD
boundary condition: true
is encoded by: hsa:23417
initial amount: NaN
initial concentration: NaN
is: O95822
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_fb07e4d1_5681_49c6_af96_e638a46b5f55
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:79646
name: PANK3
is: SBO:0000252
is: Q9H999

http://identifiers.org/biomodels.db/MODEL1310110037#_034198ca_8113_47ff_ba3f_356c868e345e
constant: false
is: O15305
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: PMM2
is encoded by: hsa:5373
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_60a9837b_de00_42fb_ad1c_d31869db5f73
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: NDUFB2
is encoded by: hsa:4708
has only substance units: false
is: H7C5B8

http://identifiers.org/biomodels.db/MODEL1310110037#_3d000d77_3beb_461a_b832_f87ee7f47b7b
name: MTHFS
has only substance units: false
is: P49914
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:10588
initial amount: NaN
initial concentration: NaN
constant: false

metaM HC02187 c
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
initial amount: NaN
constant: false
type: Species
name: reverse-triiodthyronine
is: CHEBI:28774
has only substance units: false
is: SBO:0000247

metaM HC01104 e
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:61146
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
name: 4-nitrophenyl phosphate(2-)
initial amount: NaN

metaR r0345
is described by: ECO:0000000
modifier: MODEL1310110037#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaM 3php c
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01024
name: 3-phosphonatooxypyruvate(3-)
constant: false
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
is: CHEBI:18110

metaR ADEt
fast: false
name: adenine reversible transport, cytosol
product: MODEL1310110037#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reactant: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
reversible: true

metaR GCC2am
fast: false
type: Reaction
kinetic law: MODEL1310110037#
is described by: ECO:0000269
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.4.4.2
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110037#

metaM dcyt e
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00881
boundary condition: false
is: CHEBI:15698
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
is: HMDB00014
constant: false

metaM tag hs e
initial amount: NaN
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
name: triglyceride
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:17855
initial concentration: 1.0

metaR r1833
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
fast: false

metaR r2537
fast: false
name: Utilized transport
reversible: true
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
type: Reaction

metaR DOLMANP Lter
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110037#
fast: false
name: dolichol-phosphate mannose flippase (liver)
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR r2110
reversible: true
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_4e02d2a8_fcab_4dc6_b77f_25b18eda0456
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4967
is: Q02218
type: Species
constant: false
name: OGDH
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r0021
fast: false
reversible: true
reactant: MODEL1310110037#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110037#
product: MODEL1310110037#

metaM k c
initial amount: NaN
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0
has only substance units: false
is: C00238
boundary condition: false
is: CHEBI:29103
constant: false
is: SBO:0000247
name: potassium
is: HMDB00586
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_3d1b0767_9ac8_4e5d_bf8c_01e2df8113eb
is: SBO:0000252
is: Q9NWU1
boundary condition: true
name: OXSM
has only substance units: false
constant: false
is encoded by: hsa:54995
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_f647d657_1a65_482d_836e_01f35fad3abd
is: SBO:0000297
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:6520
has only substance units: false
name: SLC7A10:SLC3A2
has part: P08195
is encoded by: hsa:56301
has part: Q9NS82

metaM prostgd2 r
is: CHEBI:57406
type: Species
initial amount: NaN
name: prostaglandin D2(1-)
is: HMDB01403
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
constant: false

metaM leuktrA4 c
is: HMDB01337
is: CHEBI:57463
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: SBO:0000247
constant: false
name: leukotriene A4(1-)
boundary condition: false

metaR GACPAILter
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
fast: false
name: glucosaminyl-acylphosphatidylinositol ER flippase
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_0f4226a9_300a_4ecd_b26e_7e29f85ac1a0
constant: false
has only substance units: false
boundary condition: true
type: Species
name: SLCO2A1
is: Q92959
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6578

metaM dlnlcgcoa c
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27979
boundary condition: false
constant: false
type: Species
name: dihomo-gamma-linolenyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110037#_8cc56623_e3f9_4b80_9a2f_c6db4f4119ba
is: A6H8L5
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3990
constant: false
boundary condition: true
name: LIPC
type: Species
initial amount: NaN
initial concentration: NaN

metaR r2538
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
fast: false
name: Utilized transport
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#

metaM retinol 9 cis c
is: SBO:0000247
name: 9-cis-retinol
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06217
boundary condition: false
is: CHEBI:17336
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
type: Species
has only substance units: false

metaR r0022
type: Reaction
product: MODEL1310110037#
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
reactant: MODEL1310110037#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
modifier: MODEL1310110037#
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000176

metaR r2111
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
kinetic law: MODEL1310110037#

metaR r0456
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110037#
reversible: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
type: Reaction
product: MODEL1310110037#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM HC02187 e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:28774
name: reverse-triiodthyronine

metaM dcyt c
is: CHEBI:15698
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00014
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: C00881

metaM tag hs c
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
name: triglyceride
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:17855
initial concentration: 1.0

metaR ALR2
name: aldose reductase (methylglyoxal)
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110037#
reversible: false
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
modifier: MODEL1310110037#

metaM CE5788 e
initial concentration: 1.0
constant: false
is: HMDB02710
has only substance units: false
name: kinetensin 1-7
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:27485

metaR PETOHMm hs
type: Reaction
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
product: MODEL1310110037#
name: phosphatidylethanolamine N-methyltransferase
is described by: ECO:0000254
reversible: false
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.1.1.17
fast: false
kinetic law: MODEL1310110037#
is: SBO:0000176
modifier: MODEL1310110037#

metaM HC02202 e
name: prostaglandin A1(1-)
is: CHEBI:57398
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM o2s e
initial concentration: 1.0
is: HMDB02168
boundary condition: false
initial amount: NaN
is: CHEBI:18421
is: SBO:0000247
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
name: superoxide
has only substance units: false

metaR r2112
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#

metaR FPGS9m
is version of: http://identifiers.org/ec-code/6.3.2.17
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000176
name: folylpolyglutamate synthetase (10fthf), mitochondrial
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110037#

metaR LEUKTRB4t
name: leukotriene B4 transport
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_9b8779c5_7585_4ea6_b660_92011c7afa92
initial amount: NaN
is encoded by: hsa:2876
type: Species
name: GPX1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: P07203

metaR GLUt6
name: Glutamate transport via Na, H symport and K antiport
modifier: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
type: Reaction
reversible: false
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_5cdc8f98_61a9_467d_b539_f754230fb937
has only substance units: false
constant: false
initial concentration: NaN
name: AACS
type: Species
is: SBO:0000252
is encoded by: hsa:65985
boundary condition: true
initial amount: NaN
is: Q86V21

http://identifiers.org/biomodels.db/MODEL1310110037#_801bce5a_6461_4967_8a84_7302d9d9d976
is: Q9NVE7
type: Species
has only substance units: false
boundary condition: true
constant: false
name: PANK4
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55229

metaR DGULND
product: MODEL1310110037#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
name: dehydro-L-gulonate decarboxylase
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD

metaR r0714
fast: false
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110037#
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_2c3c4381_8b39_4142_832a_5cc3e4699c69
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: VNN1
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:8876
is: O95497

metaR ALR3
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
fast: false
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: aldose reductase (acetol)
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_3801f96f_1cd8_412b_b95c_4d415c651a6e
is: SBO:0000252
name: ALDH9A1
initial concentration: NaN
is: P49189
constant: false
boundary condition: true
type: Species
is encoded by: hsa:223
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_4355b06c_a2c8_40c8_ab7a_118aef02b508
is encoded by: hsa:56848
initial concentration: NaN
initial amount: NaN
name: SPHK2
boundary condition: true
is: SBO:0000252
is: Q9NRA0
has only substance units: false
constant: false
type: Species

metaM cala c
constant: false
type: Species
is: CHEBI:11892
initial amount: NaN
is: SBO:0000247
name: N-carbamoyl-beta-alaninate
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00026

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_256cf779_6144_4b45_9954_a8f187e4ae1e
type: Species
initial amount: NaN
is: SBO:0000252
is: P43353
name: ALDH3B1
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:221

metaR r2113
kinetic law: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
modifier: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r1600
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110037#

metaR PYRt2m
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
fast: false
is described by: ECO:0000000
reversible: true
name: pyruvate mitochondrial transport via proton symport
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110037#

metaM ivcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
initial concentration: 1.0
has only substance units: false
is: CHEBI:57345
name: Isovaleryl-CoA
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01113
constant: false

metaR HIBDm
reversible: true
modifier: MODEL1310110037#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.31
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
reactant: MODEL1310110037#
is: SBO:0000176
fast: false

metaR HISTAtu
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
type: Reaction
reversible: true
is: SBO:0000185
name: Histamine uniport
product: MODEL1310110037#
reactant: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_b1d5f84a_aa2b_4eed_8801_293462d57750
initial amount: NaN
is encoded by: hsa:6528
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: Q92911
name: SLC5A5
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_df2fb4df_463d_447f_b527_74bdcaefc445
name: CTPS1
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:1503
is: P17812
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_c5e1abfe_c9d0_4bab_a2e7_9372586cc050
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: ADSS
initial amount: NaN
is: P30520
has only substance units: false
is encoded by: hsa:159
type: Species

metaR r1837
kinetic law: MODEL1310110037#
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110037#
is: SBO:0000185

metaR DESAT20 1
is described by: ECO:0000000
reactant: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110037#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_0a4ef56c_4827_471a_8807_c75bc780a245
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: B2RDZ2
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:55312
name: RFK

metaM cholate e
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:29747
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
boundary condition: false
is: HMDB00619
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110037#_63b48259_da36_494d_bffd_1bdd54223b4c
has only substance units: false
is: Q5DSZ6
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: UGT1A8
is encoded by: hsa:54576
initial amount: NaN

metaR r2473
is: SBO:0000185
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
reactant: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.4.5
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110037#

metaR r1690
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110037#
type: Reaction
reactant: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaR r0670
is described by: ECO:0000000
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
product: MODEL1310110037#
type: Reaction
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110037#_5bbed707_2f57_4975_9760_2c8c9a160c79
constant: false
is encoded by: hsa:11332
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: O00154
name: ACOT7
initial concentration: NaN
boundary condition: true

metaR r2114
product: MODEL1310110037#
modifier: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110037#
reversible: true
type: Reaction

metaM pe hs e
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
constant: false
is: SBO:0000247
name: phosphatidylethanolamine
initial concentration: 1.0

metaM 10fthf5glu m
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6
has only substance units: false
is: SBO:0000247
type: Species

metaM HC02202 c
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0
boundary condition: false
is: CHEBI:57398
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

metaM o2s c
is: SBO:0000247
name: superoxide
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
is: HMDB02168

http://identifiers.org/biomodels.db/MODEL1310110037#_d7676c75_b5f7_484d_8b3d_e266dfeb992b
boundary condition: true
name: _AI990637_1_x
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:AI990637
initial amount: NaN
is: SBO:0000252

metaM g6p r
is: C00092
name: D-Glucose 6-phosphate
type: Species
initial amount: NaN
constant: false
is: CHEBI:61548
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
has only substance units: false
is: SBO:0000247
is: HMDB01401
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_a7ff10fc_b23a_4954_945f_abd098fb0c31
is: Q5SPY7
name: ENTPD2
boundary condition: true
is encoded by: hsa:954
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

metaM dgmp e
is: SBO:0000247
boundary condition: false
has only substance units: false
name: dGMP(2-)
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
is: HMDB01044
is: CHEBI:57673

http://identifiers.org/biomodels.db/MODEL1310110037#_12e54acc_b50a_4e26_ad37_59d620a49617
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: RDH14
boundary condition: true
is: Q9HBH5
is encoded by: hsa:57665

http://identifiers.org/biomodels.db/MODEL1310110037#_3a724867_b896_4ff8_871f_b274df4f5932
name: PANK1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q8TE04
is: SBO:0000252
is encoded by: hsa:53354
constant: false
boundary condition: true
type: Species

metaM 10fthf5glu l
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110037#_43bf9cf4_a0fb_4add_9c5e_81d4e627e548
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: TM7SF2
is: O76062
is encoded by: hsa:7108
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_bf77240a_5a29_45ea_9da6_48d4d93ca23f
name: MECR
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:51102
type: Species
constant: false
is: Q9BV79

http://identifiers.org/biomodels.db/MODEL1310110037#_a941f954_d56b_4769_9785_9627554ef32b
type: Species
initial amount: NaN
name: NDUFC1
is: O43677
is encoded by: hsa:4717
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR RE3627M
product: MODEL1310110037#
name: RE3627
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

metaR r2115
modifier: MODEL1310110037#
is described by: ECO:0000000
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_3670b529_d84e_4f12_86d2_385ba142b947
boundary condition: true
is encoded by: hsa:U37519
type: Species
name: _U37519_1_m
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR DURAD
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2
name: dihydrouracil dehydrogenase (NADP)
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_5b9acb30_7ef7_4e42_b289_49ff52320349
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: Q01959
is encoded by: hsa:6531
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC6A3

http://identifiers.org/biomodels.db/MODEL1310110037#_251dbf14_e9e9_404e_b5c1_8b1f878b3416
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29925
type: Species
has only substance units: false
name: GMPPB

metaR H8TAer
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
reactant: MODEL1310110037#
name: H8 transamidase, endoplasmic reticulum
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_291e9899_fd81_4ee0_b41c_aabc0b7760c2
type: Species
has only substance units: false
is encoded by: hsa:51095
constant: false
initial amount: NaN
name: TRNT1
is: Q96Q11
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r1377
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000176
type: Reaction
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
reactant: MODEL1310110037#
fast: false
product: MODEL1310110037#

metaR r0960
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110037#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
reversible: true
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_57c9db89_6ae7_4ea4_aa27_2692cbabeb6c
has part: Q8TBF5
is encoded by: hsa:54965
initial amount: NaN
has part: Q9H3S5
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:93183
constant: false
type: Species
name: PIGX:PIGM
has only substance units: false
boundary condition: true

metaM ahcys c
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16680
is: HMDB00939
is: C00021
boundary condition: false

metaM cholate c
is: CHEBI:29747
boundary condition: false
is: HMDB00619
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: Cholate

metaR SR5ARr
fast: false
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000176
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is version of: http://identifiers.org/ec-code/1.3.99.5
reversible: false
modifier: MODEL1310110037#
is described by: ECO:0000134
type: Reaction

metaR P5CRxm
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
is described by: ECO:0000304
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
reversible: false
is: SBO:0000176
reactant: MODEL1310110037#
fast: false
name: pyrroline-5-carboxylate reductase (m)

http://identifiers.org/biomodels.db/MODEL1310110037#_55da2c49_fd39_4f83_a435_e75999659935
initial amount: NaN
constant: false
is encoded by: hsa:AI440329
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AI440329_1_r
boundary condition: true
type: Species

metaR r0340
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: false
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
type: Reaction
modifier: MODEL1310110037#
is: SBO:0000176

metaR LCADi
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110037#
product: MODEL1310110037#
name: lactaldehyde dehydrogenase
fast: false
reactant: MODEL1310110037#
reversible: false

metaR H2O2t
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
reversible: true
name: hydrogen peroxide transport via diffusion
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false

metaM pe hs c
name: phosphatidylethanolamine
constant: false
has only substance units: false
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR r2116
is: SBO:0000185
fast: false
product: MODEL1310110037#
kinetic law: MODEL1310110037#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110037#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_e20f0c14_0b2d_44b3_a2cb_4240003325b2
boundary condition: true
is: O14495
name: PPAP2B
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:8613
type: Species

metaR HYXNt
reactant: MODEL1310110037#
is: SBO:0000185
kinetic law: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
type: Reaction
reversible: true
name: Hypoxanthine transport
fast: false

metaR r1378
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
is described by: ECO:0000000
product: MODEL1310110037#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110037#
fast: false
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
kinetic law: MODEL1310110037#

metaR UMPK7n
reversible: true
name: UMP kinase (dGTP),nuclear
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#

metaM k e
initial amount: NaN
name: potassium
is: CHEBI:29103
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
constant: false
is: C00238
has only substance units: false
type: Species
is: HMDB00586
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM dhbpt c
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: 6,7-dihydrobiopterin
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: CHEBI:20680
initial amount: NaN
is: HMDB00038
is: SBO:0000247

metaM ser L e
is: HMDB00187
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
initial concentration: 1.0
name: L-serine
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_38e45ddd_acb3_473a_a301_d9844f208768
is: O95861
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: BPNT1
has only substance units: false
is encoded by: hsa:10380
constant: false
type: Species

metaM HC00900 c
initial concentration: 1.0
constant: false
initial amount: NaN
name: Methylmalonate
type: Species
has only substance units: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: CHEBI:30860
is: SBO:0000247
boundary condition: false

metaM mescon m
initial concentration: 1.0
is: HMDB00749
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
type: Species
is: CHEBI:36986
is: SBO:0000247
initial amount: NaN
name: Mesaconate
constant: false
has only substance units: false

metaM frdp c
is: HMDB00961
is: CHEBI:175763
name: Farnesyl diphosphate
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: C00448
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110037#_0b946f4f_6f9e_48a1_b782_f90812ef7f80
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: P61457
is encoded by: hsa:5092
constant: false
name: PCBD1
has only substance units: false

metaM dgmp c
is: CHEBI:57673
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01044
has only substance units: false
is: SBO:0000247
name: dGMP
type: Species
is: C00362

metaM leuktrA4 e
initial amount: NaN
is: HMDB01337
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: CHEBI:57463
name: leukotriene A4(1-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_995a9105_b2a2_413c_ae6c_7e700ee180d0
is: SBO:0000252
initial concentration: NaN
is: Q9H6Y6
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:4645
boundary condition: true
constant: false
name: MYO5B

metaM dolmanp U c
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
boundary condition: false
name: Dolichyl phosphate D-mannose, human uterine homolog
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:15809
type: Species

http://identifiers.org/biomodels.db/MODEL1310110037#_e4509041_83bd_4762_8c05_1c0ae29650a7
is: SBO:0000252
initial concentration: NaN
name: AMY1A
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:276
type: Species
is: Q6NSB3

http://identifiers.org/biomodels.db/MODEL1310110037#_b4bdc151_977a_4f65_b369_1e78676304ef
is encoded by: hsa:4726
has only substance units: false
is: Q6IBC4
initial concentration: NaN
name: NDUFS6
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM 3mb2coa m
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01493
constant: false
boundary condition: false
name: 3-methylbut-2-enoyl-CoA(4-)
is: CHEBI:57344
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069

metaM gam6p c
type: Species
initial amount: NaN
initial concentration: 1.0
name: D-Glucosamine 6-phosphate
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: CHEBI:12962
is: SBO:0000247
constant: false
is: HMDB01254
has only substance units: false
boundary condition: false

metaR AMPtp
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110037#
name: AMP transporter, peroxisome
fast: false
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
product: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_20dabdc0_b07a_4fea_8c03_ec9f6336245d
has only substance units: false
constant: false
is encoded by: hsa:9107
initial concentration: NaN
initial amount: NaN
is: Q9Y217
boundary condition: true
is: SBO:0000252
type: Species
name: MTMR6

http://identifiers.org/biomodels.db/MODEL1310110037#_74bd5a91_d54d_485b_914e_75e2384c214f
boundary condition: true
is: O15245
is encoded by: hsa:6580
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: SLC22A1
initial amount: NaN
type: Species

metaR LGTHL
is described by: ECO:0000269
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
reversible: false
product: MODEL1310110037#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
name: lactoylglutathione lyase
is version of: http://identifiers.org/ec-code/4.4.1.5
modifier: MODEL1310110037#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_0a8fae9d_61b1_4182_986f_a4c19fc4cdf8
is: P49247
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: RPIA
is encoded by: hsa:22934
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_debe60f8_21c2_46b4_b43d_afe104d6f827
type: Species
is: O15357
is encoded by: hsa:3636
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: INPPL1

metaM 4ppan c
type: Species
initial concentration: 1.0
name: D-4'-Phosphopantothenate
is: C03492
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:10986
is: HMDB01016
boundary condition: false
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR r0450
is described by: ECO:0000000
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reversible: true
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is: SBO:0000176
modifier: MODEL1310110037#
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_a07b5551_0566_41e4_8197_8b3a776d822b
is encoded by: hsa:55753
constant: false
type: Species
is: SBO:0000252
name: OGDHL
initial concentration: NaN
initial amount: NaN
is: Q9ULD0
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_18011bef_ca67_4ccd_973b_1010edb0b0dc
constant: false
is encoded by: hsa:2194
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: FASN
is: P49327
initial concentration: NaN

metaR NTD7
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000269
fast: false
product: MODEL1310110037#
is: SBO:0000176
type: Reaction
name: 5'-nucleotidase (AMP)
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.3.5

metaM ser L c
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: L-serine
is: CHEBI:17115
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species
initial amount: NaN
is: HMDB00187

metaR CYTK9
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110037#
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP)
is: SBO:0000176
product: MODEL1310110037#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110037#

metaR r1167
name: EC:2.3.1.26
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is described by: ECO:0000000
reversible: false
product: MODEL1310110037#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110037#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_7f6cd6d9_b04f_4444_9014_bc80c1848661
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2954
is: A6NED0
initial amount: NaN
type: Species
name: GSTZ1
constant: false
boundary condition: true
is: SBO:0000252

metaM ump r
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
constant: false
name: UMP
type: Species
is: CHEBI:57865
has only substance units: false

metaR MDHm
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110037#
name: malate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.37
is: SBO:0000176
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
product: MODEL1310110037#

metaM aps c
constant: false
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
initial concentration: 1.0
boundary condition: false
is: HMDB01003
has only substance units: false
name: 5'-adenylyl sulfate(2-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:58243
type: Species

metaR r1581
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_1b7be219_4dc6_42bb_a441_44c79345e1b3
is: SBO:0000252
is encoded by: hsa:3155
has only substance units: false
is: Q6IBC0
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: HMGCL

http://identifiers.org/biomodels.db/MODEL1310110037#_956078c0_05bf_4ee2_bf70_48bdf6a4cc2d
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:284098
name: PIGW
has only substance units: false
boundary condition: true
type: Species
is: Q7Z7B1

metaM o2s n
type: Species
constant: false
initial concentration: 1.0
is: HMDB02168
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
name: superoxide

metaR CYSGLTH
name: Glutathione:cystine oxidoreductase
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
type: Reaction
kinetic law: MODEL1310110037#
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110037#

metaM gchola e
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00138
notes: FORMULA: C26H43NO6 CHARGE: 0
type: Species
initial concentration: 1.0
name: glycocholate

metaR AKGMALtm
reversible: true
product: MODEL1310110037#
is described by: ECO:0000269
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
fast: false
type: Reaction
name: alpha-ketoglutarate/malate transporter
modifier: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV

metaR HSD3B7P
type: Reaction
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
fast: false
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000269
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.181
is: SBO:0000176

metaR RE2269E
is described by: ECO:0000000
modifier: MODEL1310110037#
product: MODEL1310110037#
name: RE2269
is version of: http://identifiers.org/ec-code/3.4.21.39
is: SBO:0000176
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
type: Reaction
reactant: MODEL1310110037#
fast: false
reversible: true
kinetic law: MODEL1310110037#

metaR NAHCO3 HCLt
product: MODEL1310110037#
modifier: MODEL1310110037#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
name: bicarbonate transport (HCl/NaHCO3 exchange)
kinetic law: MODEL1310110037#
fast: false

metaR CYTK5n
modifier: MODEL1310110037#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
reactant: MODEL1310110037#
reversible: true
product: MODEL1310110037#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
name: cytidylate kinase (CMP),nuclear
kinetic law: MODEL1310110037#
is: SBO:0000176

metaR SPMTDe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
name: SPMTDe
reversible: true
is described by: ECO:0000134
product: MODEL1310110037#
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110037#_77445678_2434_4dda_ba14_4ff6000028d7
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:BG035985
boundary condition: true
has only substance units: false
constant: false
name: _BG035985_1_c
initial amount: NaN

metaR r1584
kinetic law: MODEL1310110037#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110037#
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110037#_7b39977f_b5d9_4397_be67_d1d1b23161de
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: _AI926493_1_m
is: SBO:0000252
is encoded by: hsa:AI926493

metaR CYTK8
is described by: ECO:0000269
name: cytidylate kinase (CMP,dATP)
type: Reaction
modifier: MODEL1310110037#
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reactant: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_ea82576c_781f_4e55_9910_5cad2917c5ff
name: DECR1
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: Q16698
has only substance units: false
is encoded by: hsa:1666
initial concentration: NaN
is: SBO:0000252

metaM dttp n
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
is: SBO:0000247
is: HMDB01342
is: C00459
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR CMPACNAtn
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
name: CMP-Sia nuclear export

metaM o2s m
initial concentration: 1.0
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
name: Superoxide anion
boundary condition: false
type: Species
constant: false
has only substance units: false
is: C00704
is: SBO:0000247
is: CHEBI:18421

metaR NTD9
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110037#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110037#
name: 5'-nucleotidase (GMP)
reversible: false
is described by: ECO:0000134
modifier: MODEL1310110037#

metaR O2tp
fast: false
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
product: MODEL1310110037#
name: O2 transport, peroxisomal
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reversible: true
is described by: ECO:0000000

metaR SUCD1m
fast: false
product: MODEL1310110037#
modifier: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.3.5.1
is: SBO:0000176
reversible: true
reactant: MODEL1310110037#
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is described by: ECO:0000134
name: succinate dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110037#_6dcdf134_3f86_4de7_8992_1da6da06ac18
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:51102
name: MECR
is: SBO:0000252
is: Q9BV79
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_b78b185f_36c2_41b4_8a29_ba83fc5e3f9f
is: SBO:0000252
has only substance units: false
is encoded by: hsa:221
type: Species
name: ALDH3B1
initial amount: NaN
boundary condition: true
is: P43353
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_6a0aea6a_47ab_4bcd_b5c3_0dac81948129
is: Q3I5F7
is: SBO:0000252
initial amount: NaN
type: Species
name: ACOT6
boundary condition: true
is encoded by: hsa:641372
constant: false
initial concentration: NaN
has only substance units: false

metaR ALASm
reactant: MODEL1310110037#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
name: 5-aminolevulinate synthase
product: MODEL1310110037#
modifier: MODEL1310110037#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.3.1.29
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.3.1.37
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110037#_86d40c17_6db5_4e46_8bc8_77a2f2c0207a
constant: false
initial amount: NaN
is: P21912
name: SDHB
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6390
has only substance units: false
type: Species
boundary condition: true

metaR NADPtru
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000185
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: NADP transporter, endoplasmic reticulum
reactant: MODEL1310110037#

metaR r1583
is described by: ECO:0000000
product: MODEL1310110037#
reversible: true
fast: false
reactant: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110037#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110037#_181c05b9_b258_4cad_abd2_d5ae7d5f40d9
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7001
type: Species
has only substance units: false
initial concentration: NaN
name: PRDX2
initial amount: NaN
constant: false

metaR ADPtx
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110037#
type: Reaction
fast: false
is: SBO:0000185
name: ADP transporter, peroxisomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110037#_fd7e8a15_d2b6_41c9_9c5f_81af2857c42d
name: PPCS
is encoded by: hsa:79717
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9HAB8
boundary condition: true
constant: false
has only substance units: false

metaR r2532
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
is: SBO:0000185
type: Reaction

metaR CYTK7
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110037#
fast: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: cytidylate kinase (CMP,UTP)
modifier: MODEL1310110037#

metaR r1487
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
name: EC:6.2.1.3
reactant: MODEL1310110037#
fast: false
product: MODEL1310110037#

metaM ocdcea l
type: Species
is: CHEBI:30823
has only substance units: false
is: HMDB00207
is: SBO:0000247
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
boundary condition: false
initial concentration: 1.0
name: oleate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_40f63b71_d39a_4305_a141_9fa8178c0585
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: QPRT
boundary condition: true
is encoded by: hsa:23475
initial concentration: NaN
constant: false
is: Q15274

metaM ach e
is: HMDB00895
has only substance units: false
is: CHEBI:15355
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
name: acetylcholine
is: SBO:0000247
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_2402e40c_c38b_44cf_a65d_610f5fbda646
is encoded by: hsa:5211
has part: Q7L2M7
is: SBO:0000297
type: Species
initial concentration: NaN
boundary condition: true
name: PFKL:PFKP
constant: false
has only substance units: false
initial amount: NaN

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR RE0383C
name: RE0383
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
modifier: MODEL1310110037#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110037#_7779b8b8_a25a_4fd0_a65f_e7838ca1a9c8
name: INPP5E
is encoded by: hsa:56623
boundary condition: true
initial amount: NaN
is: Q9NRR6
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR r0679
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110037#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_23faeaf7_5c31_40b4_918b_20aed1b07aa4
boundary condition: true
name: NDUFA3
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4696
constant: false
is: SBO:0000252
is: O95167

metaM ala B c
has only substance units: false
initial amount: NaN
is: CHEBI:16958
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
is: SBO:0000247
boundary condition: false
name: beta-alanine

metaM thbpt4acam n
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
boundary condition: false
type: Species
is: HMDB02281
constant: false
is: CHEBI:15374
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_5021487f_c0b6_484d_8f26_3b6fc731bf31
name: PTS
constant: false
has only substance units: false
is: SBO:0000252
is: Q03393
is encoded by: hsa:5805
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_f106f8ea_d5e7_4012_8e44_fdf105d76237
boundary condition: true
type: Species
is encoded by: hsa:10455
has only substance units: false
is: O75521
initial concentration: NaN
constant: false
initial amount: NaN
name: ECI2
is: SBO:0000252

metaM pa hs c
name: phosphatidate(2-)
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57739

http://identifiers.org/biomodels.db/MODEL1310110037#_d51ef232_eff5_4fdc_aeec_f88743943280
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6389
constant: false
is: P31040
boundary condition: true
initial amount: NaN
type: Species
name: SDHA
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_c0c1fe46_3b54_4057_9e20_60228e948311
is encoded by: hsa:54539
constant: false
has only substance units: false
type: Species
is: Q9NX14
initial concentration: NaN
initial amount: NaN
name: NDUFB11
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110037#_935e0f44_cc04_4e5e_9b67_acde5fccfde4
initial concentration: NaN
name: PRDX2
is: P32119
constant: false
is encoded by: hsa:7001
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110037#_05c4fed0_7ccc_41b2_846c_fc35dbdeeac6
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:343
name: AQP8
initial concentration: NaN
is: O94778
constant: false

http://identifiers.org/biomodels.db/MODEL1310110037#_eef4c74f_d04a_4815_80da_dc67ff8d46fd
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: Q92903
is encoded by: hsa:1040
name: CDS1

metaM prostgd2 e
has only substance units: false
is: SBO:0000247
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
constant: false
is: CHEBI:57406
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR 4ABUTtcn
type: Reaction
is described by: ECO:0000134
product: MODEL1310110037#
fast: false
name: transport of GABA
kinetic law: MODEL1310110037#
reversible: false
is: SBO:0000185
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.

metaR CHOLt4
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
type: Reaction
name: choline, sodium cotransport
is described by: ECO:0000269
product: MODEL1310110037#
is: SBO:0000185
modifier: MODEL1310110037#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD

metaR ALCD21 L
is: SBO:0000176
kinetic law: MODEL1310110037#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.99.24
product: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
reactant: MODEL1310110037#
name: alcohol dehydrogenase (L-1,2-propanediol)
modifier: MODEL1310110037#
is described by: ECO:0000304

metaR r0603
reversible: true
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
reactant: MODEL1310110037#
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176

metaM pe hs m
constant: false
boundary condition: false
name: phosphatidylethanolamine
initial amount: NaN
has only substance units: false
is: CHEBI:16038
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
type: Species

metaR r0716
kinetic law: MODEL1310110037#
is described by: ECO:0000000
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110037#

metaM HC02179 e
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: CHEBI:34306
boundary condition: false
name: 20-hydroxy-arachidonate
constant: false
type: Species
initial concentration: 1.0

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR DHFR
reactant: MODEL1310110037#
modifier: MODEL1310110037#
product: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is: SBO:0000176
name: dihydrofolate reductase
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000254
kinetic law: MODEL1310110037#
fast: false

metaM ach c
constant: false
type: Species
is: HMDB00895
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
is: SBO:0000247
name: acetylcholine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_676c7b7e_a0b0_4399_b3f6_f397fb39fd02
boundary condition: true
has only substance units: false
name: UAP1
type: Species
is: Q16222
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:6675

metaM ump n
is: HMDB00288
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:57865
name: UMP(2-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM ocdcea r
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: CHEBI:0
type: Species
is: HMDB00207
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00712
notes: FORMULA: C18H33O2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110037#_11c76287_bf17_4695_8b4a_9a54e1803197
type: Species
is: SBO:0000252
initial amount: NaN
is: E7EML0
is encoded by: hsa:9498
boundary condition: true
name: SLC4A8
has only substance units: false
initial concentration: NaN
constant: false

metaR r2534
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
is: SBO:0000185
product: MODEL1310110037#
kinetic law: MODEL1310110037#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110037#

metaR r2320
reactant: MODEL1310110037#
product: MODEL1310110037#
kinetic law: MODEL1310110037#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110037#_30c2ba83_4ce1_479d_9176_8aceb820e59e
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: GPX1
is: SBO:0000252
is encoded by: hsa:2876

metaM man6p c
boundary condition: false
constant: false
is: CHEBI:17369
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01078
name: D-Mannose 6-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: SBO:0000247

metaM pre prot r
is: HMDB03125
constant: false
name: glycophosphatidylinositol (GPI)-anchored protein precursor
has only substance units: false
notes: FORMULA: XY CHARGE: 0
type: Species
initial concentration: 1.0
is: CHEBI:16240
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM 10fthf5glu e
boundary condition: false
is: HMDB00108
constant: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: CHEBI:16236
initial amount: NaN
name: 10-formyltetrahydrofolate-[Glu](5)
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r0604
fast: false
reactant: MODEL1310110037#
is described by: ECO:0000000
kinetic law: MODEL1310110037#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is: SBO:0000176
product: MODEL1310110037#
reversible: false
modifier: MODEL1310110037#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168

http://identifiers.org/biomodels.db/MODEL1310110037#_79b3878c_0f6c_4224_89b9_ae2253f3a6d5
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: Q8WZ48
boundary condition: true
name: CPT1A
is encoded by: hsa:1374
is: SBO:0000252
constant: false

metaR RE0691C
is: SBO:0000176
kinetic law: MODEL1310110037#
is described by: ECO:0000000
fast: false
product: MODEL1310110037#
name: RE0691
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110037#
reversible: true

metaR r1010
reversible: true
name: Postulated transport reaction
product: MODEL1310110037#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction

metaR r0560
is described by: ECO:0000000
reactant: MODEL1310110037#
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
reversible: false
kinetic law: MODEL1310110037#
type: Reaction
product: MODEL1310110037#
is: SBO:0000176
fast: false

metaR r1580
kinetic law: MODEL1310110037#
fast: false
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110037#
reactant: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r2535
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110037#
product: MODEL1310110037#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110037#
reversible: true

metaR r2321
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110037#
product: MODEL1310110037#
reversible: true
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110037#_252cb6c8_a328_400d_b037_09ddc72cbba5
constant: false
has only substance units: false
initial concentration: NaN
name: SLC23A1
is: SBO:0000252
type: Species
is encoded by: hsa:9963
is: Q9UHI7
initial amount: NaN
boundary condition: true

metaM e4p c
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial amount: NaN
initial concentration: 1.0
name: D-Erythrose 4-phosphate
type: Species
is: HMDB01321
is: C00279
constant: false
is: CHEBI:16897

metaM 34dhmald m
is: HMDB06242
boundary condition: false
is: C05577
type: Species
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false
is: SBO:0000247
name: 3,4-Dihydroxymandelaldehyde
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7903
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110037#_f5b4382f_bbeb_4265_b190_6636b79fa38b
initial amount: NaN
has part: Q9HCC0
constant: false
type: Species
boundary condition: true
is encoded by: hsa:64087
has part: Q96RQ3
name: MCCC1:MCCC2
is: SBO:0000297
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56922

metaM prostgd2 c
boundary condition: false
constant: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
is: HMDB01403
is: CHEBI:57406
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: prostaglandin D2(1-)

metaR ORNDC
modifier: MODEL1310110037#
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
reactant: MODEL1310110037#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110037#
is version of: http://identifiers.org/ec-code/4.1.1.17
type: Reaction
product: MODEL1310110037#
fast: false
name: Ornithine Decarboxylase

metaR HISCAT1
kinetic law: MODEL1310110037#
product: MODEL1310110037#
reactant: MODEL1310110037#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110037#_9c793cd2_8620_4bf0_8a6a_02182c3cf61d
constant: false
name: SLC7A8
boundary condition: true
type: Species
is: Q86U05
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23428
has only substance units: false

metaR RBFK
fast: false
is described by: ECO:0000269
name: riboflavin kinase
product: MODEL1310110037#
kinetic law: MODEL1310110037#
modifier: MODEL1310110037#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.26
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaR r0718
type: Reaction
kinetic law: MODEL1310110037#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.181
reversible: false
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110037#
product: MODEL1310110037#
is described by: ECO:0000000
modifier: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_c551a391_3a1b_401b_b974_88442f2cc32c
is encoded by: hsa:5330
boundary condition: true
initial concentration: NaN
type: Species
is: Q59F77
constant: false
initial amount: NaN
has only substance units: false
name: PLCB2
is: SBO:0000252

metaR P45027A1m
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110037#
kinetic law: MODEL1310110037#
product: MODEL1310110037#
is: SBO:0000176
reactant: MODEL1310110037#
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: false
type: Reaction
is described by: ECO:0000269
name: Cytochrome P450 27

metaM succoa m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
constant: false
type: Species
name: Succinyl-CoA
is: SBO:0000247
is: HMDB01022
boundary condition: false
is: CHEBI:57292

metaR r2322
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110037#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
reactant: MODEL1310110037#

http://identifiers.org/biomodels.db/MODEL1310110037#_640c7841_f35c_43ed_8805_287cf9fef6f5
has only substance units: false
is encoded by: hsa:84129
name: ACAD11
boundary condition: true
type: Species
is: Q709F0
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

metaR PROSTGI2t
reactant: MODEL1310110037#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110037#
fast: false
kinetic law: MODEL1310110037#
name: Prostaglandin I2 transport
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110037#_ffa7dbbc_2ac9_4b7c_ad94_12ee0ba0f654
is: P23921
boundary condition: true
is: SBO:0000252
type: Species
name: RRM1
constant: false
has only substance units: false
is encoded by: hsa:6240
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110037#_871db200_0b5c_4c8e_a0d7_6812e408d239
is: P45954
has only substance units: false
is encoded by: hsa:36
initial amount: NaN
initial concentration: NaN
name: ACADSB
is: SBO:0000252
boundary condition: true
type: Species
constant: false

given: Neil
family: Swainston

orgname: University of Manchester