http://identifiers.org/biomodels.db/MODEL1310110036#_370d2b56_4200_46d7_bcd3_dd57c990ced4
type: Species
name: AMPD2
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:271
is: Q01433
initial amount: NaN

metaR Htg
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
reversible: true
name: proton diffusion (Golgi)
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#

metaM Lfmkynr c
notes: FORMULA: C11H12N2O4 CHARGE: 0 INCHI: InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00985 EHMN_ABBREVIATION: C02700
type: Species
initial amount: NaN
is: HMDB01200
initial concentration: 1.0
boundary condition: false
is: CHEBI:30249
name: N-formyl-L-kynurenine
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_b47e1d22_f4dd_4a26_961d_7a7e4e584fec
initial amount: NaN
name: BPNT1
is: O95861
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:10380

metaM gthrd c
boundary condition: false
is: SBO:0000247
is: C00051
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
name: Reduced glutathione
is: HMDB00125
is: CHEBI:57925

metaR r1893
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_246ceb7d_7631_4824_b359_3b8a3a9591ad
constant: false
is: O95497
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8876
boundary condition: true
type: Species
name: VNN1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_1e69702a_3277_44af_899d_c99e9f2a457b
is: SBO:0000252
boundary condition: true
name: _BE966236_1_m
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:BE966236

metaR r0437
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is version of: http://identifiers.org/ec-code/4.1.2.13
product: MODEL1310110036#
is: SBO:0000176
fast: false
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true
reactant: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR r0226
reversible: false
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
reactant: MODEL1310110036#
fast: false
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000176

metaR r2314
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110036#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true

metaM 5adtststerone r
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
has only substance units: false
is: SBO:0000247
is: HMDB02961
is: CHEBI:16330
initial concentration: 1.0
boundary condition: false

metaR CHOLATEt
modifier: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000269
name: cholate transport via bicarbonate countertransport
reactant: MODEL1310110036#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_30aee20b_7679_4e13_8e93_fdc54f16fd74
name: COX6B1
boundary condition: true
constant: false
is encoded by: hsa:1340
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P14854
initial concentration: NaN

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1f2c2833_534a_4569_bc9d_32629aaec0e4
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
name: _AA526438_1_c
initial concentration: NaN
is encoded by: hsa:AA526438

metaM rib D c
name: D-ribose
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00283
is: SBO:0000247
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: CHEBI:16988
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_735bb0b6_3d14_4b7d_a670_774ce568d76c
type: Species
constant: false
is: E5KSL6
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:1716
boundary condition: true
is: SBO:0000252
name: DGUOK

http://identifiers.org/biomodels.db/MODEL1310110036#_9ff83bc7_fc34_42c1_8221_76f939e67d3f
boundary condition: true
name: PPA1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5464
has only substance units: false
initial amount: NaN
is: Q15181
type: Species
constant: false

metaM paps c
is: HMDB01134
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
constant: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
type: Species
is: CHEBI:58339
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_4eafba08_a3fc_4798_b2b4_036945c7c875
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: O00767
is encoded by: hsa:6319
name: SCD
constant: false
is: SBO:0000252

metaR FADDPle
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000134
name: FAD diphosphatase
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: false

metaM kynate c
is: HMDB00715
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
name: kynurenate
is: CHEBI:58454
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

metaM maltttr e
initial concentration: 1.0
is: C02052
name: Maltotetraose
initial amount: NaN
constant: false
is: HMDB01296
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
type: Species
is: http://identifiers.org/pubchem.compound/5141
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR r1380
type: Reaction
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
reversible: true

metaR L LACt2r
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
name: L-lactate reversible transport via proton symport
fast: false
reversible: true
modifier: MODEL1310110036#
product: MODEL1310110036#

metaR RE1517M
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
fast: false
name: RE1517
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_e40b3b6e_1aaf_482c_999d_3e1b3b5bd5b1
constant: false
initial amount: NaN
name: DGKB
is: Q9Y6T7
has only substance units: false
type: Species
is encoded by: hsa:1607
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r0641
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true
kinetic law: MODEL1310110036#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
modifier: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_56b1d175_489c_4541_bed2_b7767f15d530
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q15738
is: SBO:0000252
is encoded by: hsa:50814
type: Species
initial amount: NaN
name: NSDHL

metaR UDPGALtg
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
name: UDP-Gal Golgi transport via CMP antiport
reactant: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD

metaM CE5132 c
is: SBO:0000247
type: Species
constant: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial amount: NaN
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110036#_ba931171_9dfe_4a89_a885_a75edeebaacc
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:226
has only substance units: false
name: ALDOA

metaM HC01496 m
is: CHEBI:28095
has only substance units: false
initial amount: NaN
name: 2-Amino-3-oxoadipate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
constant: false
is: SBO:0000247
type: Species

metaR r2313
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110036#
reversible: true
fast: false
reactant: MODEL1310110036#
type: Reaction

metaR FUMm
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
name: fumarase, mitochondrial
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
is version of: http://identifiers.org/ec-code/4.2.1.2
product: MODEL1310110036#
fast: false
is: SBO:0000176

metaR 2HBO
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
is: SBO:0000176
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110036#_8d3587d6_e3ea_4ba4_815d_34b63c7621b4
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q8IXW6
constant: false
is encoded by: hsa:1809
initial concentration: NaN
name: DPYSL3
is: SBO:0000252

metaR GLCt1r
name: glucose transport (uniport)
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
reversible: true
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110036#

metaM gthrd e
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: glutathionate(1-)
is: HMDB00125
has only substance units: false
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_f9c22ff3_e8eb_444e_b633_bc266f5ad102
initial amount: NaN
type: Species
is: SBO:0000252
is: O95340
is encoded by: hsa:9060
initial concentration: NaN
name: PAPSS2
boundary condition: true
constant: false
has only substance units: false

metaM nadph x
is: C00005
is: HMDB00221
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR r0642
kinetic law: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
reversible: true
fast: false
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
type: Reaction
is described by: ECO:0000000

metaR r2316
kinetic law: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110036#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110036#

metaM pram c
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
type: Species
is: C03090
is: HMDB01128
name: 5-Phospho-beta-D-ribosylamine
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58681
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_19bedbd8_2347_4693_b5e1_e741c4666816
constant: false
boundary condition: true
name: GGH
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:8836
is: Q92820
has only substance units: false
is: SBO:0000252

metaM rib D e
is: HMDB00283
type: Species
name: D-ribose
has only substance units: false
boundary condition: false
is: CHEBI:16988
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
is: SBO:0000247
constant: false

metaR PPItr
fast: false
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110036#
name: Diphosphate transporter, endoplasmic reticulum
is: SBO:0000185
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_82d2fa4a_9ff3_4147_a548_96ab9ce2d320
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:51727
initial amount: NaN
name: CMPK1
type: Species
boundary condition: true
has only substance units: false
is: B2R6S5

http://identifiers.org/biomodels.db/MODEL1310110036#_99a1f1f0_325e_4249_9dd7_772a8b9f7bd6
name: PKM2
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5315
constant: false
is: SBO:0000252

metaM dsmsterol r
name: desmosterol
is: HMDB02719
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
is: CHEBI:17737

metaM nicrns c
is: CHEBI:58527
has only substance units: false
initial amount: NaN
boundary condition: false
name: Nicotinate D-ribonucleoside
type: Species
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
constant: false
is: SBO:0000247
is: HMDB06809
initial concentration: 1.0

metaR r0587
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reactant: MODEL1310110036#
fast: false
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_e85463d6_3df0_4db8_8028_06fb6ded2d69
is: SBO:0000252
initial amount: NaN
is: Q13011
constant: false
boundary condition: true
name: ECH1
type: Species
initial concentration: NaN
is encoded by: hsa:1891
has only substance units: false

metaR LEUTA
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
kinetic law: MODEL1310110036#
type: Reaction
fast: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is: SBO:0000176
name: leucine transaminase

metaR r0434
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110036#
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110036#
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaR MTHGXLt
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
reversible: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: Methylglyoxal transport (cytosol to extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110036#_0fe9799a_fbc7_4c5b_8071_2aeb4293d674
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: AHCYL1
is: O43865
type: Species
constant: false
is encoded by: hsa:10768

metaM CE5586 c
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
is: SBO:0000247
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
is: CHEBI:58732
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_9bd4cff0_4797_4d8a_b2df_0a6b2b920025
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: TXNRD3
is: Q86VQ6
is encoded by: hsa:114112
type: Species
constant: false
is: SBO:0000252

metaR r2315
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_340f3008_d51d_4317_aa71_7c5f35b5c629
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110036#_31821f67_f6c6_4c0f_9b51_372991066e17
initial amount: NaN
is: SBO:0000252
name: _LOC728997_1_c
boundary condition: true
has only substance units: false
is encoded by: hsa:LOC728997
type: Species
constant: false
initial concentration: NaN

metaM bildglcur r
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471

http://identifiers.org/biomodels.db/MODEL1310110036#_925e3f0f_cc00_45b1_80ba_8d1f09d62fc8
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: TDO2
is: P48775
is encoded by: hsa:6999
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM co2 m
initial amount: NaN
name: CO2
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
is: CHEBI:16526
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: C00011
is: HMDB01967

http://identifiers.org/biomodels.db/MODEL1310110036#_0f577023_1d45_40bd_90b5_b493645594e7
constant: false
initial amount: NaN
is encoded by: hsa:124637
boundary condition: true
type: Species
initial concentration: NaN
name: CYB5D1
is: Q6P9G0
is: SBO:0000252
has only substance units: false

metaR r2318
is: SBO:0000185
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b8cf7b8e_d762_44dc_9e6c_3d911eb8bfce
is: P43353
is: SBO:0000252
is encoded by: hsa:221
name: ALDH3B1
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_6d5ef828_314f_4a03_9015_107243907afd
is: SBO:0000252
is encoded by: hsa:6580
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: SLC22A1
has only substance units: false
boundary condition: true
is: O15245

http://identifiers.org/biomodels.db/MODEL1310110036#_aefe4ecf_f9e9_4bea_8988_413647d42a6b
is encoded by: hsa:2678
initial amount: NaN
has only substance units: false
constant: false
is: P19440
boundary condition: true
type: Species
initial concentration: NaN
name: GGT1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_82578c49_be1b_4629_b016_1b9f50615593
initial amount: NaN
is: O75912
is: SBO:0000252
has only substance units: false
type: Species
name: DGKI
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9162

metaR G6PDH2rer
modifier: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
is described by: ECO:0000269
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
reversible: true
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR r1302
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
name: Vesicular transport
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_74424840_fb65_48ae_9645_f6205b7b014a
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5211
is: P17858
name: PFKL
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_a7270837_52c6_4490_9844_a06f86c5dd81
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q6FGV9
boundary condition: true
is encoded by: hsa:10654
name: PMVK
type: Species

metaR RTOTAL2FATPc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal2 by enterocytes
type: Reaction

metaR NDPK1
reversible: true
fast: false
name: nucleoside-diphosphate kinase (ATP:GDP)
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r0644
kinetic law: MODEL1310110036#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is described by: ECO:0000000

metaR C3STKR2r
modifier: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
product: MODEL1310110036#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
name: C-3 sterol keto reductase (zymosterol)
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000134

metaM leu L m
is: CHEBI:15603
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
name: L-leucine
is: SBO:0000247
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
boundary condition: false

metaM cmp n
is: HMDB00095
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: CMP(2-)
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_3e471a7c_9bc4_4ebb_ab22_893faeb20dac
is: SBO:0000252
is encoded by: hsa:2348
initial amount: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
name: FOLR1
initial concentration: NaN

metaR r2317
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true

metaR r1384
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
fast: false
name: Guanosine aminohydrolase EC:3.5.4.15
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:

metaM paps g
is: SBO:0000247
initial amount: NaN
is: HMDB01134
is: CHEBI:58339
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false

metaM o2 e
type: Species
is: C00007
boundary condition: false
has only substance units: false
name: O2
constant: false
initial concentration: 1.0
is: CHEBI:15379
is: HMDB01377
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR r1301
product: MODEL1310110036#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
name: Vesicular transport

http://identifiers.org/biomodels.db/MODEL1310110036#_12823fc6_b79b_4b4b_a1b3_aadb2ee4680f
is: P48426
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: PIP4K2A
is encoded by: hsa:5305

metaR CGLYt3 2
is described by: ECO:0000304
product: MODEL1310110036#
reactant: MODEL1310110036#
name: Cys-Gly transport in via proton symport
kinetic law: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
type: Reaction
reversible: false

metaR GGH 7THFe
name: Gamma-glutamyl hydrolase (7THF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
fast: false
is: SBO:0000176

metaR CHSTEROLtrc
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110036#
name: transport of cholesterol into the cytosol
product: MODEL1310110036#
is described by: ECO:0000134

metaR r1803
reversible: false
is: SBO:0000185
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
name: Y+LAT2 Utilized transport

metaM 6thf e
name: hexaglutamyl folate (THF)
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: http://identifiers.org/pubchem.compound/169691
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_0ae3672d_b4ba_4fee_8c40_4f33463b8e25
name: RRM2
boundary condition: true
constant: false
is: P31350
has only substance units: false
initial amount: NaN
is encoded by: hsa:6241
type: Species
is: SBO:0000252
initial concentration: NaN

metaM dhbpt c
initial concentration: 1.0
has only substance units: false
name: 6,7-dihydrobiopterin
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
boundary condition: false
is: SBO:0000247
is: HMDB00038
type: Species
is: CHEBI:20680
initial amount: NaN

metaR RE1520M
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1520
reversible: true
type: Reaction

metaR r1381
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reversible: true
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_707faed7_711d_46ec_b04b_597261305fc3
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
name: PANK2
is encoded by: hsa:80025
is: Q9BZ23

http://identifiers.org/biomodels.db/MODEL1310110036#_6aed52f6_738e_4ba2_8188_7801864bca80
is encoded by: hsa:155184
boundary condition: true
is: Q6PXP3
name: SLC2A7
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_8613707d_0c11_4132_861b_8f5eec633617
type: Species
has only substance units: false
name: LDHC
is: SBO:0000252
constant: false
is encoded by: hsa:3948
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r0584
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reactant: MODEL1310110036#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaM ttdca e
is: HMDB00806
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: tetradecanoate (n-C14:0)
type: Species
is: C06424
is: CHEBI:30807
constant: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424

metaM akg m
is: C00026
name: 2-Oxoglutarate
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00208
has only substance units: false
initial concentration: 1.0
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
boundary condition: false

metaR 5ADTSTSTERONEte
reversible: true
is: SBO:0000185
name: 5 alpha dihydrotesterone transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#

metaR RE1807C
product: MODEL1310110036#
is: SBO:0000176
name: RE1807
kinetic law: MODEL1310110036#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false

metaM lnlccoa m
type: Species
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01064
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial amount: NaN

metaM msa m
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
name: 3-oxopropanoate
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
is: CHEBI:33190
is: HMDB11111
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_4d4c35fa_14e8_4e74_aeef_d4450c3cbe90
type: Species
is encoded by: hsa:7355
initial concentration: NaN
is: P78381
has only substance units: false
initial amount: NaN
name: SLC35A2
constant: false
boundary condition: true
is: SBO:0000252

metaM oaa c
is: HMDB00223
name: Oxaloacetate
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00036
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:3338
notes: FORMULA: C4H2O5 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110036#_3b3a8293_db28_4818_a2f7_a4691aaa1f42
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC4A10
boundary condition: true
type: Species
is: B7Z1R0
is encoded by: hsa:57282
is: SBO:0000252
has only substance units: false

metaM HC00342 m
boundary condition: false
name: cis-aconitate(3-)
is: CHEBI:16383
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR SR5ARr
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.5
reversible: false
reactant: MODEL1310110036#
product: MODEL1310110036#
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
kinetic law: MODEL1310110036#
is described by: ECO:0000134
modifier: MODEL1310110036#

metaM dtmp m
is: C00364
has only substance units: false
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
boundary condition: false
is: HMDB01227
type: Species
is: SBO:0000247
is: CHEBI:26999
name: dTMP
initial concentration: 1.0
initial amount: NaN

metaM 20ahchsterol m
boundary condition: false
name: 20-hydroxycholesterol
initial amount: NaN
type: Species
is: CHEBI:1296
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: HMDB06283
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR 34DHXMANDACOX
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
modifier: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
product: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269

metaR UMPK7n
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: UMP kinase (dGTP),nuclear
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110036#
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110036#_907c1c1e_5a6f_4c54_a10c_95039609947a
initial amount: NaN
type: Species
is: O14521
name: SDHD
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6392
constant: false
is: SBO:0000252

metaR r2319
reversible: true
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

metaR SARCStex
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
is: SBO:0000185
name: Sarcosine transport (extracellular to cytosol)
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
fast: false
reversible: false
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_4aa43b1a_4357_4dc8_ba9a_aaf2f0fb88d2
initial concentration: NaN
name: _AF080579_1_c
is encoded by: hsa:AF080579
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_4e9dfb01_68c5_40df_92e6_19919e283c89
has only substance units: false
is: SBO:0000252
is encoded by: hsa:26266
constant: false
initial concentration: NaN
type: Species
is: Q9UKG4
name: SLC13A4
initial amount: NaN
boundary condition: true

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1dc04274_a150_4b76_ba74_cb7a1e4675fb
name: CHAT
has only substance units: false
is: P28329
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1103

metaR r1538
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_abb3f61f_851c_4af3_b4ff_bb922e13edc0
name: ACO2
is: Q99798
constant: false
initial concentration: NaN
is encoded by: hsa:50
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_fab89715_b774_47a0_b885_eee88bf0eb7a
is encoded by: hsa:3033
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: Q16836
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: HADH

http://identifiers.org/biomodels.db/MODEL1310110036#_335b30c7_50ae_4b72_949b_5f3008dd4c10
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _AA788780_1_c
is encoded by: hsa:AA788780
constant: false
initial concentration: NaN

metaR DALAt2r
kinetic law: MODEL1310110036#
is: SBO:0000185
name: D-alanine transport via proton symport
is described by: ECO:0000304
fast: false
reversible: true
reactant: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
product: MODEL1310110036#

metaR AKR1D
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.3
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reversible: false
is: SBO:0000176
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269
fast: false

metaM pro L m
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:17203
name: L-proline
boundary condition: false
constant: false

metaR r0647
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
name: Spontaneous reaction
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#

metaR RE3006M
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
modifier: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
name: RE3006
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_6761db2d_9cc2_4ebd_b58a_a075eb3fa0e3
constant: false
is: P33316
is encoded by: hsa:1854
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: DUT
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_2d486107_3df8_47e2_98ad_7c80c63a0828
constant: false
name: CA12
is: O43570
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:771
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_bb6d8461_7e4d_4b20_9099_ef6acb550b8d
is encoded by: hsa:7360
is: SBO:0000252
initial amount: NaN
name: UGP2
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaR PUNP1
reversible: true
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Adenosine)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#

metaR NDPK5
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110036#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
product: MODEL1310110036#
is described by: ECO:0000269
reactant: MODEL1310110036#
name: Nucleoside-diphosphate kinase (ATP:dGDP)

metaR PI45P5P
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
modifier: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110036#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.3.36

metaR PSFLIPm
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.1
name: phosphatidylserine flippase
is described by: ECO:0000269
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ

metaM dtmp c
is: SBO:0000247
constant: false
name: dTMP
is: CHEBI:26999
initial amount: NaN
boundary condition: false
is: C00364
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
type: Species
initial concentration: 1.0

metaR r1451
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: false
is: SBO:0000176
name: EC:1.3.3.6
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false

metaR NACHEX27ly
reversible: false
type: Reaction
kinetic law: MODEL1310110036#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000269
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110036#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD

metaR PRODt2r
type: Reaction
product: MODEL1310110036#
reversible: true
is: SBO:0000185
name: D-proline reversible transport via proton symport
fast: false
is described by: ECO:0000304
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaM sphs1p e
boundary condition: false
is: HMDB00277
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119

metaR ALADGLYexR
modifier: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
name: D-alanine/glycine reversible exchange
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
is described by: ECO:0000304

metaM dump m
has only substance units: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
constant: false
initial concentration: 1.0
is: SBO:0000247
name: dUMP(2-)
initial amount: NaN
boundary condition: false
is: HMDB01409
type: Species
is: CHEBI:246422

metaM succoa x
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01022
name: Succinyl-CoA

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR r0753
modifier: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: SBO:0000176
fast: false
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:

metaR GLYCtm
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
is: SBO:0000185
name: glycerol transport
kinetic law: MODEL1310110036#
fast: false

metaR r2534
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110036#

metaM nadph m
boundary condition: false
type: Species
is: CHEBI:57783
constant: false
is: C00005
initial concentration: 1.0
is: HMDB00221
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaM o2 r
name: O2
initial amount: NaN
is: HMDB01377
type: Species
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: C00007
is: CHEBI:15379

metaR r0754
fast: false
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
type: Reaction
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110036#

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM imp e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: HMDB00175
boundary condition: false
is: CHEBI:58053
name: IMP(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_5d9e4dc1_d4a1_4fbc_a4b1_8289e9597582
is: Q8WUM9
boundary condition: true
is encoded by: hsa:6574
constant: false
type: Species
initial concentration: NaN
name: SLC20A1
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM prostgd2 e
type: Species
initial amount: NaN
name: prostaglandin D2(1-)
is: CHEBI:57406
is: HMDB01403
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial concentration: 1.0

metaR NDPK4
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
fast: false
modifier: MODEL1310110036#
name: nucleoside-diphosphate kinase (ATP:dTDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_775ef716_5a3d_408d_a4eb_a67928fd6545
has only substance units: false
name: SLC26A8
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:116369
initial concentration: NaN
boundary condition: true

metaR r2140
type: Reaction
product: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110036#
reversible: true
is described by: ECO:0000000

metaM udpglcur c
boundary condition: false
is: HMDB00935
has only substance units: false
name: UDP-D-glucuronate
is: CHEBI:58052
is: C00167
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
constant: false
type: Species
initial amount: NaN

metaM pacald c
initial amount: NaN
type: Species
is: HMDB06236
name: phenylacetaldehyde
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16424
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601

http://identifiers.org/biomodels.db/MODEL1310110036#_1d863136_5ac9_4880_9084_fbe932ba5f25
constant: false
is: O75414
has only substance units: false
type: Species
name: NME6
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:10201

metaR PAPStg
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110036#
name: 3'-Phosphoadenylyl sufate Golgi transport
type: Reaction
reversible: true
reactant: MODEL1310110036#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_eb02601d_ee74_44eb_a714_5a29e4ea4ff1
is encoded by: hsa:80704
is: Q9BZV2
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC19A3

metaM retinal c
is: SBO:0000247
is: CHEBI:15035
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
has only substance units: false
is: HMDB01358

metaM CE5786 e
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN
is: HMDB02710
has only substance units: false
is: CHEBI:27485
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: kinetensin
is: SBO:0000247

metaM atp x
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57299
is: SBO:0000247
is: C00002
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00538
name: ATP(4-)

metaM gmp e
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01397
name: GMP(3-)
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: CHEBI:58115

metaM cholate r
notes: FORMULA: C24H39O5 CHARGE: -1 INCHI: InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:29747
name: cholate
is: HMDB00619
has only substance units: false
constant: false
is: SBO:0000247

metaM HC01522 c
type: Species
name: Gentisate aldehyde
boundary condition: false
is: CHEBI:28508
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaR r0755
modifier: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:

metaR r1899
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185
type: Reaction

metaR PUNP3
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110036#
name: purine-nucleoside phosphorylase (Guanosine)
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR r2141
product: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110036#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_9b500154_72af_453b_8976_ecb5f272776f
is: P12074
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: COX6A1
constant: false
is: SBO:0000252
is encoded by: hsa:1337

http://identifiers.org/biomodels.db/MODEL1310110036#_cf311780_974e_4cd3_a65f_57dcebd23fa2
initial amount: NaN
name: CYP27A1
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: Q02318
initial concentration: NaN
is encoded by: hsa:1593
constant: false

metaR GALU
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/2.7.7.9
type: Reaction
reversible: true
modifier: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000134
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
name: UTP-glucose-1-phosphate uridylyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_1f16dfdb_56e4_45bc_af7d_4e310be54e51
is: Q8TE04
has only substance units: false
initial concentration: NaN
is encoded by: hsa:53354
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: PANK1

metaR NDPK3
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:CDP)
modifier: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1c809a1d_ccf8_4277_b021_f0d184765674
boundary condition: true
constant: false
type: Species
name: PCBD1
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:5092
initial concentration: NaN
is: P61457

http://identifiers.org/biomodels.db/MODEL1310110036#_5d65731d_01f0_4fc2_9fe8_735534809d22
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: BDH1
initial concentration: NaN
is encoded by: hsa:622
type: Species
has only substance units: false
constant: false

metaR EHGLAT2m
is described by: ECO:0000304
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: false
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
kinetic law: MODEL1310110036#

metaM fdp c
constant: false
name: D-Fructose 1,6-bisphosphate
is: HMDB01058
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
has only substance units: false
is: C00354
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3647
is: CHEBI:16905

metaM sphs1p c
type: Species
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
constant: false
is: HMDB00277
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:60119
initial amount: NaN

metaR r1453
is: SBO:0000176
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
fast: false
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8

metaR RDH2
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
type: Reaction
name: retinol dehydrogenase (9-cis,NADH)

metaR r0142
modifier: MODEL1310110036#
type: Reaction
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reactant: MODEL1310110036#
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM cmp c
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
boundary condition: false
is: HMDB00095
has only substance units: false
type: Species
name: CMP
constant: false
initial concentration: 1.0
is: CHEBI:60377
is: SBO:0000247
is: C00055

metaM co2 c
is: HMDB01967
is: CHEBI:3313
initial amount: NaN
boundary condition: false
name: CO2
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0
is: C00011
is: SBO:0000247

metaR OCDCEAtr
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
product: MODEL1310110036#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110036#_6d73ba53_960a_4330_8950_7e21c1f8444a
has only substance units: false
name: SLC25A1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6576
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: D9HTE9

metaM gthrd m
constant: false
is: HMDB00125
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
boundary condition: false
is: CHEBI:57925
type: Species
name: glutathionate(1-)
initial amount: NaN

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR r0377
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
type: Reaction
fast: false
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
modifier: MODEL1310110036#
reversible: false

metaM prostgd2 c
name: prostaglandin D2(1-)
is: SBO:0000247
is: CHEBI:57406
initial amount: NaN
initial concentration: 1.0
is: HMDB01403
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false

metaR PUNP2
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: purine-nucleoside phosphorylase (Deoxyadenosine)
reversible: true
product: MODEL1310110036#

metaR RE2541E
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110036#
reversible: true
name: RE2541
reactant: MODEL1310110036#
type: Reaction

metaM CE4794 m
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: cis-6-dodecenoyl-CoA
is: CHEBI:57923

metaR r2532
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_e93b0eb2_e493_456f_a136_947183023726
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: GGT7
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:2686
is: A0PJJ9

http://identifiers.org/biomodels.db/MODEL1310110036#_3622cccf_0c5d_4873_83c1_6eeed8630a2d
has only substance units: false
type: Species
name: SLC23A1
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9963
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_8c54a1e9_a2c2_4fd2_913b_25fa6e661376
initial concentration: NaN
constant: false
is: Q86XP1
initial amount: NaN
is encoded by: hsa:160851
type: Species
is: SBO:0000252
name: DGKH
has only substance units: false
boundary condition: true

metaR NDPK2
kinetic law: MODEL1310110036#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP)
product: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is described by: ECO:0000269

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_bec8a1d2_b853_4d87_a7f4_99df6db3110b
name: SLC6A3
is encoded by: hsa:6531
constant: false
is: Q01959
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR r2142
is: SBO:0000185
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
type: Reaction
modifier: MODEL1310110036#

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM gtp n
boundary condition: false
is: HMDB01273
has only substance units: false
constant: false
type: Species
name: GTP(4-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
is: SBO:0000247

metaR DGTPtn
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dGTP diffusion in nucleus
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_8e700145_17ae_470c_97c8_9440bbea7370
initial concentration: NaN
constant: false
is: Q96PE7
has only substance units: false
is encoded by: hsa:84693
initial amount: NaN
name: MCEE
boundary condition: true
type: Species
is: SBO:0000252

metaR CYTK2n
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
type: Reaction
fast: false
product: MODEL1310110036#
name: cytidylate kinase (dCMP),nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM dump n
initial concentration: 1.0
type: Species
is: CHEBI:246422
constant: false
name: dUMP(2-)
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: HMDB01409

metaM gmp c
is: C00144
boundary condition: false
initial amount: NaN
constant: false
name: GMP
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:58115

metaM gtp m
is: CHEBI:37565
is: HMDB01273
has only substance units: false
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: GTP
initial amount: NaN
is: C00044
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0

metaR D LACt2
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000185
name: D-lactate transport via proton symport
modifier: MODEL1310110036#

metaM leu L e
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
is: CHEBI:15603
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00687
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_1232f421_f5c6_4848_b0ed_faae3abd2091
initial concentration: NaN
is encoded by: hsa:1582
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CYP8B1
constant: false
type: Species
is: Q9UNU6

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR KYNATESYN
reversible: false
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110036#

metaR O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
reversible: true
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
name: o2 transport (diffusion)
type: Reaction
product: MODEL1310110036#

metaM 56dura c
is: HMDB00076
initial amount: NaN
name: 5,6-dihydrouracil
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
has only substance units: false
type: Species
constant: false
is: CHEBI:15901
initial concentration: 1.0

metaM nadph r
is: C00005
is: HMDB00221
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57783
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaR HDCAter
is: SBO:0000185
name: palmitate ER export
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
reversible: false

metaM oaa m
constant: false
is: CHEBI:16452
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00223
has only substance units: false
name: Oxaloacetate
type: Species
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: SBO:0000247
is: C00036

metaM glyb c
is: HMDB00043
boundary condition: false
name: glycine betaine
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:17750
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_bed9d00d_939a_4b75_81c9_56ecf4475504
is encoded by: hsa:6240
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: P23921
constant: false
name: RRM1

metaM akg c
is: SBO:0000247
type: Species
name: 2-Oxoglutarate
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00026
is: HMDB00208

metaR r2537
is described by: ECO:0000000
name: Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
reversible: true

metaM 5adtststerone e
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
is: CHEBI:16330
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
boundary condition: false
is: HMDB02961
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_f4334baf_ea40_46af_89f1_55a53361cbc6
initial amount: NaN
boundary condition: true
is encoded by: hsa:8869
initial concentration: NaN
has only substance units: false
is: Q9UNP4
is: SBO:0000252
constant: false
type: Species
name: ST3GAL5

metaM co2 e
is: HMDB01967
initial amount: NaN
type: Species
constant: false
name: CO2
is: CHEBI:16526
boundary condition: false
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
is: SBO:0000247
initial concentration: 1.0

metaM cmp e
initial amount: NaN
type: Species
constant: false
is: HMDB00095
is: CHEBI:60377
boundary condition: false
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
is: SBO:0000247
initial concentration: 1.0

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaM dcholcoa c
is: HMDB06292
type: Species
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:28701

metaR GULLACter
product: MODEL1310110036#
is: SBO:0000185
reversible: false
reactant: MODEL1310110036#
name: gulonolactone endoplasmic reticular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false

metaR NDPK8
type: Reaction
modifier: MODEL1310110036#
name: Nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#

metaR RE1691M
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
fast: false
reversible: true
is: SBO:0000176
name: RE1691
is version of: http://identifiers.org/ec-code/2.8.1.1
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:

metaR URIt5le
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: uridine transport in via sodium symport (1:2)
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000134
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d1cc5f45_d182_4d4a_9865_6427cb76819b
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:26275
name: HIBCH
initial amount: NaN
boundary condition: true
is: Q6NVY1
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_50ceac48_ba92_4031_b574_75502ffc74a6
is: SBO:0000252
initial amount: NaN
name: PAPSS1
is encoded by: hsa:9061
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: O43252
constant: false

metaR GALT
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.12
is: SBO:0000176
is described by: ECO:0000000
name: galactose-1-phosphate uridylyltransferase

metaM cmp g
boundary condition: false
initial amount: NaN
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
is: HMDB00095
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR r2144
kinetic law: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
modifier: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110036#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_c1aad11c_0cbb_4e13_86ac_5c425e475201
is: SBO:0000252
is: Q96P26
is encoded by: hsa:93034
name: NT5C1B
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_c64dbcc4_00fd_4a54_be3b_9bc0f3c6ec38
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q14376
is encoded by: hsa:2582
name: GALE
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

metaR RE2541C
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false
name: RE2541
reversible: true
type: Reaction
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_01a3b2f8_0c0f_4af3_b691_ca3135072d5e
boundary condition: true
name: _BG035985_1_c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:BG035985
has only substance units: false
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_6b98c3d2_7775_4452_a8e1_f650742384a8
has only substance units: false
constant: false
is: Q9BZQ4
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: NMNAT2
is encoded by: hsa:23057

metaM bildglcur c
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
type: Species
is: HMDB03325
is: SBO:0000247

metaR r0750
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_c1b12cb3_6039_47bb_a897_304ba47ef16d
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:130
type: Species
initial concentration: NaN
is: P28332
has only substance units: false
name: ADH6
constant: false

metaM o2 m
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01377
is: CHEBI:15379
initial amount: NaN
is: C00007
name: O2
boundary condition: false
type: Species

metaM leuleu c
boundary condition: false
notes: FORMULA: C12H24N2O3 CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: Leucylleucine
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR RE2974C
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
is: SBO:0000176
name: RE2974
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.149
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
fast: false

metaM dgdp n
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
type: Species
name: dGDP(2-)
initial amount: NaN
is: HMDB00960
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaR NDPK9
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: nucleoside-diphosphate kinase (ATP:IDP)
is described by: ECO:0000269
type: Reaction
reversible: true

metaR ITCOAL1m
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110036#
is: SBO:0000176

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaM 12ppd S c
is: HMDB06213
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
name: (S)-propane-1,2-diol
constant: false
type: Species
is: CHEBI:29002

metaM dtmp e
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: dTMP(2-)
is: HMDB01227
is: CHEBI:26999
has only substance units: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: SBO:0000247

metaR 2OXOADPTm
name: 2-oxoadipate shuttle (cytosol/mitochondria)
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877

metaM leu L c
is: CHEBI:15603
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00687
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine

metaR NDPK7
is: SBO:0000176
kinetic law: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
name: nucleoside-diphosphate kinase (ATP:dCDP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_4b8ed2b2_ced7_4fc0_b606_7c5c2ea4c3a9
name: CA8
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: P35219
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:767
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_13dc95d8_4887_48e8_aaab_eb88cc1a8cf1
constant: false
boundary condition: true
has only substance units: false
type: Species
is: Q9P212
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51196
name: PLCE1
is: SBO:0000252

metaR RE1531M
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: RE1531
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
reversible: true

metaM 10fthf5glu e
initial concentration: 1.0
constant: false
name: 10-formyltetrahydrofolate-[Glu](5)
is: CHEBI:57454
notes: FORMULA: C40H45N11O19 CHARGE: -6
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00972
type: Species
initial amount: NaN

metaR r2535
product: MODEL1310110036#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

metaR r2145
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110036#
product: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#

metaR SMPD4
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
reversible: false
is described by: ECO:0000000
name: sphingomyelinase
product: MODEL1310110036#
reactant: MODEL1310110036#

metaR FTHFL
is described by: ECO:0000134
modifier: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
name: Formate-tetrahydrofolate ligase
type: Reaction

metaM akg e
type: Species
is: CHEBI:16810
constant: false
initial amount: NaN
boundary condition: false
name: 2-oxoglutarate(2-)
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_c0d99471_1662_4bc4_98d7_e01db43d258e
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: PRPS1L1
is encoded by: hsa:221823
boundary condition: true
initial concentration: NaN

metaR SUCD1m
reactant: MODEL1310110036#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is described by: ECO:0000134
product: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.5.1
name: succinate dehydrogenase
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_50db6b6c_1c64_4909_a716_2208049e5578
initial concentration: NaN
has part: P55084
initial amount: NaN
is: SBO:0000297
type: Species
constant: false
is encoded by: hsa:3032
is encoded by: hsa:3030
has only substance units: false
boundary condition: true
has part: E9KL44
name: HADHA:HADHB

http://identifiers.org/biomodels.db/MODEL1310110036#_b93f9d81_6ce1_4912_b955_705a58e21033
has only substance units: false
initial amount: NaN
name: LGSN
constant: false
is encoded by: hsa:51557
type: Species
initial concentration: NaN
is: Q5TDP6
is: SBO:0000252
boundary condition: true

metaR ACACT7p
reversible: false
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
kinetic law: MODEL1310110036#
is described by: ECO:0000269
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176

metaR TPI
modifier: MODEL1310110036#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.1
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
fast: false
reversible: true
name: triose-phosphate isomerase
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical

metaR RE1807M
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
name: RE1807
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR NDPK6
is: SBO:0000176
reactant: MODEL1310110036#
modifier: MODEL1310110036#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110036#
is described by: ECO:0000269

metaR PPItm
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
is: SBO:0000185
reversible: true
fast: false
name: diphopshate transporter, mitochondrial
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_edec4fe6_be1a_42af_8dd4_51ab80742105
has only substance units: false
type: Species
constant: false
is: Q16831
is encoded by: hsa:7378
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: UPP1
initial amount: NaN

metaR r0752
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110036#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110036#

metaR UROLACer
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
reactant: MODEL1310110036#
name: uronolactonase, endoplasmic reticulum
is: SBO:0000176
type: Reaction

metaR UREAt5
kinetic law: MODEL1310110036#
is: SBO:0000185
name: urea, water cotransport
reversible: true
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110036#
modifier: MODEL1310110036#

metaM prpncoa m
boundary condition: false
has only substance units: false
is: CHEBI:57367
constant: false
name: acryloyl-CoA(4-)
type: Species
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: HMDB02307
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_00434d60_6d18_43d9_bc73_12137ce55aa7
has only substance units: false
boundary condition: true
is encoded by: hsa:286016
name: TPI1P2
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaR EX adprib LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose exchange
type: Reaction

metaR HYXNt
kinetic law: MODEL1310110036#
type: Reaction
fast: false
name: Hypoxanthine transport
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reversible: true
product: MODEL1310110036#
modifier: MODEL1310110036#

metaM bildglcur e
has only substance units: false
initial amount: NaN
is: HMDB03325
type: Species
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
constant: false
is: CHEBI:58471

metaM betald c
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: SBO:0000247
name: betaine aldehyde
boundary condition: false
type: Species
is: HMDB01252
is: CHEBI:15710
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_aa455c97_45c5_4f34_b13e_ab3ff6db9730
name: FASN
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2194
constant: false
boundary condition: true
is: SBO:0000252
is: P49327

http://identifiers.org/biomodels.db/MODEL1310110036#_b0c33625_b1f3_4035_828f_099a131ec662
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:1811
type: Species
name: SLC26A3
is: P40879
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_f2c17c34_87dd_488f_af07_e1df09271464
name: INPP5D
is encoded by: hsa:3635
boundary condition: true
is: SBO:0000252
type: Species
is: Q92835
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaR r0145
is: SBO:0000176
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/1.8.3.1
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_6355d387_db01_4244_a84c_f04ed6d7c188
initial concentration: NaN
has only substance units: false
is: P32019
name: INPP5B
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3633

metaR GLNtN1
fast: false
name: Glutamine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_ea9cadb6_1796_4151_b7b8_b2a9baff0f66
is: Q6LEN5
initial concentration: NaN
is: SBO:0000252
name: CHAT
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:1103

http://identifiers.org/biomodels.db/MODEL1310110036#_cd7570a5_71db_42ce_8609_37dbb9b1aba9
is: SBO:0000252
is: P04075
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:226
name: ALDOA
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_8e8f8841_180e_4afc_a98e_de55c9380e30
name: PIP4K2C
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: B3KQV3
constant: false
is encoded by: hsa:79837
type: Species
boundary condition: true

metaM mal L c
type: Species
name: (S)-malate(2-)
boundary condition: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
has only substance units: false
is: HMDB00156
is: CHEBI:15589
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_74343d88_ff72_4fa7_b5e3_99652f19ae32
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2597
is: E7EUT4
is: SBO:0000252
name: GAPDH
initial amount: NaN

metaR r2200
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false

metaM Lcystin c
type: Species
has only substance units: false
name: L-cystine
is: CHEBI:16283
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_b6d002f9_e8ed_43a3_93a2_d9e2364e5266
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:80025
initial amount: NaN
name: PANK2
is: Q6P1K9
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_dbdb0833_f745_45b4_8716_9ee723a466db
constant: false
is: SBO:0000252
is encoded by: hsa:112724
boundary condition: true
initial amount: NaN
has only substance units: false
name: RDH13
initial concentration: NaN
type: Species
is: B3KVA3

metaM dctp n
constant: false
initial concentration: 1.0
is: CHEBI:16311
is: C00458
name: dCTP
initial amount: NaN
is: HMDB00998
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_788190d2_8630_432c_8126_e77af0bbb855
boundary condition: true
is encoded by: hsa:89869
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q86YW0
name: PLCZ1
initial amount: NaN
has only substance units: false
type: Species

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_54e6bf8f_0c5a_464b_b22b_bfe33bab6fd2
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR NDP7ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110036#
reversible: false
is described by: ECO:0000269
name: nucleoside-diphosphatase (UDP), extracellular
reactant: MODEL1310110036#
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_a7fa677f_493d_427b_b87b_56e05d1f57ea
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8875
type: Species
is: SBO:0000297
has part: O95498
boundary condition: true
is encoded by: hsa:55350
initial amount: NaN
name: VNN3:VNN2:VNN1

metaR r1682
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
reversible: false
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport

metaR 3MOX4HOXPGALDOX NADP
product: MODEL1310110036#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110036#
is described by: ECO:0000304
kinetic law: MODEL1310110036#
type: Reaction
reversible: true

metaM Lcystin e
has only substance units: false
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00192
initial amount: NaN
name: L-cystine

http://identifiers.org/biomodels.db/MODEL1310110036#_1308de56_d631_4d70_9120_dde890b3c424
initial amount: NaN
name: MGLL
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:11343
is: Q99685
initial concentration: NaN
has only substance units: false

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR r2201
reactant: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction

metaM akg x
initial amount: NaN
is: HMDB00208
has only substance units: false
is: CHEBI:16810
name: 2-oxoglutarate(2-)
type: Species
initial concentration: 1.0
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
boundary condition: false
constant: false

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM damp c
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
name: dAMP(2-)
has only substance units: false
is: HMDB00905
type: Species
is: CHEBI:58245
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR r1459
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Transport reaction
product: MODEL1310110036#
is: SBO:0000185
fast: false

metaM HC02213 e
has only substance units: false
is: CHEBI:28031
boundary condition: false
constant: false
name: prostaglandin-e3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

metaM ump c
name: UMP
initial amount: NaN
is: CHEBI:57865
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
is: HMDB00288
is: C00105
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_ca80d3c6_c85e_4d59_bf42_ec69b66a8f32
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: PCBD1
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:5092

metaM 12ppd R c
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:28972
has only substance units: false
initial amount: NaN
is: HMDB01881
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
is: SBO:0000247
boundary condition: false
name: (R)-propane-1,2-diol

metaM atp r
has only substance units: false
name: ATP(4-)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: C00002
boundary condition: false
is: HMDB00538
is: CHEBI:57299
type: Species

metaM HC02193 e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1
name: glycolithocholate
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:60008
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_647a77bd_c25b_4052_b2a4_e81da926c412
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:64078
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q9HAS3
type: Species
name: SLC28A3

metaR BALAtmr
reversible: true
name: Beta-alanine reversible mitochondrial transport (diffusion)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_0d1075ac_4bdd_43cd_8290_c0940e5b0722
is encoded by: hsa:6575
type: Species
is: SBO:0000252
is: B2RBR4
name: SLC20A2
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a3cba5c6_9b4e_4c8a_b7e0_9a1e4334306f
name: ADH1B:ADH1C
has only substance units: false
is: SBO:0000297
is encoded by: hsa:126
initial concentration: NaN
has part: P00326
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaR 5ADTSTSTERONEtr
type: Reaction
is: SBO:0000185
reversible: true
name: 5 alpha dihydrotesterone intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false

metaM mal L e
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
name: (S)-malate(2-)
boundary condition: false
is: HMDB00156
has only substance units: false
constant: false
is: CHEBI:15589
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r0974
product: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
name: Active transport
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000000
is: SBO:0000185

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR r2202
type: Reaction
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_6a43388a_6e2e_42b6_bd93_3ebbd3c2629d
constant: false
is: SBO:0000252
is: Q9H999
is encoded by: hsa:79646
type: Species
boundary condition: true
name: PANK3
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR AKGDm
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (4967.2) and (1738.1 and 8050.1) and (1743.1) or (4967.1) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Citric acid cycle EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:1542694 NOTES:EC taken from Ligand TV. Genetic
is version of: http://identifiers.org/ec-code/2.3.1.61
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
reversible: false
product: MODEL1310110036#
reactant: MODEL1310110036#
name: 2-oxoglutarate dehydrogenase
fast: false
type: Reaction

metaR r0149
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1e4e2e71_7cc0_42e9_9190_748c2a5fc643
name: ADA
constant: false
has only substance units: false
is: P00813
boundary condition: true
is encoded by: hsa:100
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaR UDPGLCAter
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
reactant: MODEL1310110036#
is: SBO:0000185
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
fast: false
is described by: ECO:0000269
product: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_6a556485_1ce8_489d_8d37_f26a323eceb0
initial amount: NaN
is encoded by: hsa:197257
type: Species
constant: false
name: LDHD
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f461995f_7f73_4642_bcaf_179ef7264650
initial concentration: NaN
has only substance units: false
type: Species
is: Q9NYQ3
is encoded by: hsa:51179
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: HAO2
constant: false

metaM dgdp m
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
name: dGDP(2-)
is: CHEBI:58595
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f053feae_abc8_439d_aeac_814d9f0a8baf
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: TXNRD1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:7296
type: Species

metaR r0973
fast: false
type: Reaction
name: Facilitated diffusion
reactant: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_84314e72_2bd3_430a_99fc_24d26cc7b2ca
is: P35790
initial concentration: NaN
name: CHKA
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1119
constant: false
type: Species

metaM dhdascb c
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58070
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
has only substance units: false
name: dehydroascorbide(1-)
initial amount: NaN
is: HMDB01264

metaR CYSGLTH
is described by: ECO:0000000
name: Glutathione:cystine oxidoreductase
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110036#

metaM galside hs l
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
constant: false
type: Species
name: D-galactosyl-N-acylsphingosine
has only substance units: false
is: CHEBI:12947

http://identifiers.org/biomodels.db/MODEL1310110036#_3a765323_77c5_4c79_b887_6efe7998ec87
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:NOS2A
name: _NOS2A_1_e
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaR NCNt
type: Reaction
product: MODEL1310110036#
name: Na+/Ca2+-NH4+ exchange
fast: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reactant: MODEL1310110036#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_74999545_2568_434a_8552_dd7b98ba478a
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is: B3KVI7
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3712
name: IVD

metaR NDP8
is version of: http://identifiers.org/ec-code/2.7.4.9
is: SBO:0000176
name: nucleoside-diphosphatase (dUDP)
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_07c9b2c4_30c7_4eb0_a47b_bd30798d8d03
type: Species
initial concentration: NaN
name: FOLR1
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2348
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_383ebc39_7bbb_4806_bdc7_2698246a5dd4
is encoded by: hsa:1718
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: DHCR24
is: SBO:0000252
has only substance units: false
is: Q15392

http://identifiers.org/biomodels.db/MODEL1310110036#_fb9e0b4a_1cef_4f7c_981c_97a955f97bdf
is encoded by: hsa:34
name: ACADM
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: P11310

http://identifiers.org/biomodels.db/MODEL1310110036#_c1dfbc9f_421c_4ccb_a563_3a1dbab7fb74
is encoded by: hsa:272
initial amount: NaN
boundary condition: true
type: Species
name: AMPD3
has only substance units: false
constant: false
is: B7Z763
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_6a358003_a193_4fe6_8cc6_e381cdccc266
constant: false
is: SBO:0000252
is encoded by: hsa:3948
has only substance units: false
name: LDHC
type: Species
initial concentration: NaN
boundary condition: true
is: P07864
initial amount: NaN

metaM xoldiolone r
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false
is: HMDB02197
is: CHEBI:28477
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial concentration: 1.0

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaR FRDPtr
type: Reaction
name: lipid, flip-flop intracellular transport
reversible: true
is: SBO:0000185
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#

metaR PPNCL3
modifier: MODEL1310110036#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110036#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110036#
name: phosphopantothenate-cysteine ligase
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.3.2.5

metaR DESAT22 1p
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)

http://identifiers.org/biomodels.db/MODEL1310110036#_289816b0_5b02_4014_a800_7a4a3485da1e
type: Species
name: ALDOB
has only substance units: false
initial amount: NaN
is encoded by: hsa:229
boundary condition: true
is: P05062
is: SBO:0000252
initial concentration: NaN
constant: false

metaR RE3346C
name: RE3346
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
kinetic law: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b5d8c2b9_43e4_4243_b4e3_e65b0336e4c1
constant: false
is encoded by: hsa:3030
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: E9KL44
name: HADHA

metaR PUNP4
product: MODEL1310110036#
fast: false
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyguanosine)
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
modifier: MODEL1310110036#

metaM utp m
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
has only substance units: false
type: Species
name: UTP(4-)
initial amount: NaN
is: CHEBI:46398
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00285

http://identifiers.org/biomodels.db/MODEL1310110036#_37dee076_0199_4c95_bd37_0dc9ced7768c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AI345944_1_m
constant: false
type: Species
is encoded by: hsa:AI345944
has only substance units: false

metaR GLNyLATthc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM ump g
constant: false
is: SBO:0000247
is: CHEBI:57865
initial concentration: 1.0
type: Species
is: HMDB00288
name: UMP(2-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_56f400d9_431f_4607_ab91_aad2dd2d2aae
is encoded by: hsa:5052
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: PRDX1
constant: false

metaM 4abut m
has only substance units: false
is: C00334
boundary condition: false
constant: false
is: HMDB00112
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
type: Species
is: CHEBI:16865
initial amount: NaN
initial concentration: 1.0
name: 4-Aminobutanoate

metaM leuktrD4 e
is: CHEBI:28666
name: Leukotriene D4
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

metaM sucsal m
type: Species
is: HMDB01259
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
boundary condition: false
name: Succinic semialdehyde
initial amount: NaN
constant: false
is: CHEBI:57706
has only substance units: false
initial concentration: 1.0

metaM so4 c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16189
name: sulfate
is: HMDB01448
constant: false

metaR MCITS
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: 2-methylcitrate synthase
reactant: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_542cd4a4_00a2_4eb5_a526_5fae562ff394
initial concentration: NaN
is: SBO:0000252
type: Species
name: ALPL
boundary condition: true
initial amount: NaN
is encoded by: hsa:249
has only substance units: false
is: B7Z4Y6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_c278f9d7_faea_4809_b935_9536248bc5b5
is encoded by: hsa:18
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
name: ABAT
is: SBO:0000252
is: P80404
initial concentration: NaN
type: Species

metaR PUNP5
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Inosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_3f2a8367_4ca5_450f_b88e_a3e0e432bf4a
boundary condition: true
has only substance units: false
is encoded by: hsa:728441
name: GGT2
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

metaR r0970
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
type: Reaction
product: MODEL1310110036#
fast: false
name: Active transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_f34d7c7f_d0f4_4c12_bca4_baa6f82a5a28
is: Q9BXI2
is encoded by: hsa:83884
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: SLC25A2
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_1455c9cb_9983_48fe_b919_de0d60657305
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q06203
boundary condition: true
initial amount: NaN
is encoded by: hsa:5471
name: PPAT

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM utp n
type: Species
is: HMDB00285
initial concentration: 1.0
is: SBO:0000247
name: UTP(4-)
boundary condition: false
is: CHEBI:46398
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_a5df182f_f93e_467d_8725_e4b4ac43647c
is: Q02127
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: DHODH
is encoded by: hsa:1723

http://identifiers.org/biomodels.db/MODEL1310110036#_317c4bd5_8f78_49e3_8931_074ed0ff12d1
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: NME1
is encoded by: hsa:4830
initial amount: NaN
constant: false
initial concentration: NaN

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR BTNt4i
is: SBO:0000185
name: Biotin uptake (antiport)
fast: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110036#
reversible: false
product: MODEL1310110036#
modifier: MODEL1310110036#

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaM dhap c
boundary condition: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3411
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00111
name: Dihydroxyacetone phosphate
is: SBO:0000247
is: HMDB01473
is: CHEBI:57642

metaR CERT2gt
name: ceramide transport protein
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reversible: true
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR PUNP6
product: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
name: purine-nucleoside phosphorylase (Deoxyinosine)
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_88d87b03_efa8_432d_953f_3601fa1ecc46
constant: false
is: B1AM93
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: NDUFA8
initial concentration: NaN
is encoded by: hsa:4702

metaM o2 x
is: HMDB01377
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:15379
is: SBO:0000247
has only substance units: false
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_b03ef515_a2e1_46a4_871e_43ba4ffb7d6c
is: SBO:0000252
name: BDH1
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:622
has only substance units: false
constant: false
initial amount: NaN
is: Q02338

http://identifiers.org/biomodels.db/MODEL1310110036#_56775519_5f4f_4765_ba3b_c79363cb39ac
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
name: PEMT
constant: false
is encoded by: hsa:10400
is: SBO:0000252
is: Q9UBM1
boundary condition: true

metaR AICARte
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110036#
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110036#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_9e5d0827_daad_4544_ac8a_1c5f26584546
type: Species
is encoded by: hsa:10390
has only substance units: false
is: SBO:0000252
is: B3KN25
name: CEPT1
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaM 3hpcoa m
is: HMDB06807
initial concentration: 1.0
initial amount: NaN
name: 3-hydroxypropanoyl-CoA(4-)
is: CHEBI:58528
boundary condition: false
type: Species
constant: false
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
has only substance units: false
is: SBO:0000247

metaR RE1845C
type: Reaction
is described by: ECO:0000000
name: RE1845
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
is: SBO:0000176
kinetic law: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_3447559c_0a39_41c4_8aff_489a4ecade30
is encoded by: hsa:84701
is: Q96KJ9
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: COX4I2

metaM HC02213 c
constant: false
name: prostaglandin-e3
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
type: Species
is: CHEBI:28031
initial amount: NaN

metaM cit m
is: HMDB00094
is: SBO:0000247
type: Species
is: C00158
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
name: Citrate
initial concentration: 1.0
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158

http://identifiers.org/biomodels.db/MODEL1310110036#_6f31070b_2e0a_4b71_8f49_ccd3d7b7536a
name: _AI971036_1_x
has only substance units: false
is encoded by: hsa:AI971036
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaM CE5236 c
boundary condition: false
is: SBO:0000247
is: HMDB03952
type: Species
is: CHEBI:28002
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
has only substance units: false
initial concentration: 1.0
constant: false
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN

metaM ump e
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57865
type: Species
name: UMP(2-)
has only substance units: false
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288

metaR GLUDym
kinetic law: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
is described by: ECO:0000269
name: glutamate dehydrogenase (NADP), mitochondrial
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3
is: SBO:0000176

metaR PUNP7
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
product: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Xanthosine)
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.4.2.1

metaM leuktrD4 c
name: Leukotriene D4
is: CHEBI:28666
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB03080
has only substance units: false
initial concentration: 1.0
constant: false

metaM adp c
is: HMDB01341
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00008
initial concentration: 1.0
name: ADP
is: CHEBI:16761
constant: false
is: http://identifiers.org/pubchem.compound/3310
type: Species
is: SBO:0000247

metaR r1156
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
is described by: ECO:0000000
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: MODEL1310110036#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110036#
type: Reaction
fast: false

metaM cholate e
constant: false
type: Species
initial concentration: 1.0
name: Cholate
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00619
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
has only substance units: false
is: CHEBI:29747

metaM ps hs m
type: Species
name: ps_hs[m]
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:18303
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_0b510cbe_f9d8_4f29_9eaa_93564f0ba5b3
is: P28907
is encoded by: hsa:952
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: CD38
constant: false

metaR r0747
kinetic law: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
type: Reaction
product: MODEL1310110036#

metaM crm hs c
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: N-acylsphingosine
is: SBO:0000247
is: CHEBI:52639
constant: false

metaR GLRASE
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: glucuronolactone reductase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110036#

metaM leuktrC4 c
initial amount: NaN
is: HMDB01198
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
boundary condition: false
has only substance units: false
name: leukotriene C4(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_8f3ee12f_1654_4fd8_8b70_8be0fa98f0de
name: EHHADH
constant: false
type: Species
is encoded by: hsa:1962
is: Q9NY65
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_3ec51bbf_0ba2_4956_92f7_c2102731866d
is: Q16720
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:492
has only substance units: false
initial concentration: NaN
name: ATP2B3
boundary condition: true
constant: false

metaM dhap e
is: HMDB01473
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57642
name: glycerone phosphate(2-)
constant: false

metaR DCMPDA
is described by: ECO:0000254
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.12
name: dCMP deaminase
reactant: MODEL1310110036#

metaR PPItx
product: MODEL1310110036#
name: Diphosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_43119fec_d869_43e0_a9bd_0236554e1495
has only substance units: false
is: SBO:0000252
is: P32929
name: CTH
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:1491
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_7e1b7898_99b3_4c23_87b5_a8956c642be1
has only substance units: false
type: Species
is: Q5QPH3
boundary condition: true
constant: false
name: ACSS2
is: SBO:0000252
is encoded by: hsa:55902
initial amount: NaN
initial concentration: NaN

metaR SQLEr
type: Reaction
name: Squalene epoxidase, endoplasmic reticular (NADP)
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is described by: ECO:0000134
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.14.13.132
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110036#

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: pentaglutamyl folate (DHF)
is: HMDB06487
initial concentration: 1.0

metaR r2420
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
type: Reaction

metaM co2 r
is: SBO:0000247
name: CO2
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
is: HMDB01967
is: C00011

http://identifiers.org/biomodels.db/MODEL1310110036#_d6b07847_8f7f_4530_bc8d_0e5cf5981577
has only substance units: false
type: Species
is: Q86YI5
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1737
name: DLAT

http://identifiers.org/biomodels.db/MODEL1310110036#_9d281ca2_c1c9_415f_a0ab_66f589da38ff
initial amount: NaN
is encoded by: hsa:5335
constant: false
name: PLCG1
is: SBO:0000252
type: Species
has only substance units: false
is: Q9UFY1
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_977d540c_ab1e_4d28_86b6_20460b5aabc2
name: ABP1
has only substance units: false
is: P19801
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:26
type: Species

metaR CITRtm
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110036#
reversible: true
is described by: ECO:0000269
name: citrulline mitochondrial transport via proton antiport
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#

metaM sph1p c
is: HMDB01383
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57939
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN

metaM cholate c
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:29747
initial amount: NaN
is: SBO:0000247
name: Cholate
type: Species
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial concentration: 1.0
is: HMDB00619

metaR AHC
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.3.1.1
name: adenosylhomocysteinase
reactant: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
reversible: true

metaR 2MCITt
is: SBO:0000185
kinetic law: MODEL1310110036#
name: 2-methylcitrate transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110036#

metaM mi34p c
has only substance units: false
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
is: HMDB06235
initial concentration: 1.0
is: CHEBI:28858
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: 1D-myo-Inositol 3,4-bisphosphate

http://identifiers.org/biomodels.db/MODEL1310110036#_eeae305c_f9d9_4e49_8232_2f61c8d2fe16
boundary condition: true
initial concentration: NaN
is: A8K7W0
name: VNN2
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:8875

metaM dhf c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: 7,8-Dihydrofolate
is: CHEBI:57451
is: HMDB01056
constant: false
is: C00415
type: Species

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_b3f139b1_237b_4a89_bd1e_d6cdf9cf8ad7
initial concentration: NaN
is: SBO:0000252
name: SLC5A5
constant: false
initial amount: NaN
type: Species
is: Q92911
boundary condition: true
is encoded by: hsa:6528
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_11d11c23_9413_412c_a495_15c39dd062b7
is: SBO:0000252
is encoded by: hsa:54539
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: NDUFB11
is: Q9NX14
boundary condition: true
initial concentration: NaN

metaM CE2418 m
constant: false
is: HMDB11123
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:28387
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: SBO:0000247

metaR r0502
is: SBO:0000176
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reactant: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
is described by: ECO:0000000
product: MODEL1310110036#

metaM xoldiolone c
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: HMDB02197
type: Species
has only substance units: false
initial concentration: 1.0
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: CHEBI:28477
is: SBO:0000247

metaM dgdp c
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: C00361
name: dGDP
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00960

metaR NH4tp
is: SBO:0000185
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
type: Reaction
name: ammonia peroxisomal transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r1745
product: MODEL1310110036#
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_be180cc3_5d0a_4bba_9393_6bc503153d0f
is encoded by: hsa:AI435857
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: _AI435857_1_x

metaR DM dgtp n
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgtp(n)
type: Reaction

metaM leuktrC4 e
is: HMDB01198
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57973
boundary condition: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
has only substance units: false
name: leukotriene C4(2-)
initial concentration: 1.0
initial amount: NaN

metaR ALADGLNexR
name: L-alanine/glutamine reversible exchange
reactant: MODEL1310110036#
reversible: true
is: SBO:0000185
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR TTDCAtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
is: SBO:0000185
reactant: MODEL1310110036#
name: tetradecanoate (transport)

metaR 10FTHFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_f59cb342_cfb0_46a0_81eb_8707c2fabebe
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6240
is: P23921
name: RRM1
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM orot e
is: SBO:0000247
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:30839
has only substance units: false
name: orotate
is: HMDB00226
type: Species

metaR r0638
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.8.1.2
reactant: MODEL1310110036#
reversible: true
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM sph1p e
constant: false
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57939
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: HMDB01383

metaM so4 e
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01448
has only substance units: false
initial amount: NaN
is: CHEBI:16189
type: Species
name: sulfate

metaM HC01403 m
initial amount: NaN
is: SBO:0000247
is: CHEBI:28325
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
name: (S)-Hydroxydecanoyl-CoA
has only substance units: false
boundary condition: false

metaM dhf e
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: dihydrofolate(2-)
is: HMDB01056
is: CHEBI:57451
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_4da56bb4_4317_48ed_a515_6d83993f5aa3
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:AI935189
initial amount: NaN
name: _AI935189_1_m
is: SBO:0000252

metaR r0580
is version of: http://identifiers.org/ec-code/1.3.99.7
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
modifier: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_82bb61a2_fbc6_4a12_aefb_a292a5b27de6
is encoded by: hsa:2806
name: GOT2
is: P00505
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

metaR ARGLYSex
is: SBO:0000185
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reversible: false
modifier: MODEL1310110036#
fast: false
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
name: Arginine/Lysine exchanger (Arg in)

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR DURAD2
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is described by: ECO:0000269
reversible: true
is: SBO:0000176
name: dihydrothymin dehydrogenase (NADP)
fast: false
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_d7ebf2af_9ba6_4b48_b169_008b657fcd40
name: HSD17B4
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3295
is: E9PB82
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaM CE2431 m
is: CHEBI:57795
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
has only substance units: false
name: cis-deca-4-enoyl-CoA
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaR r0860
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.27
is described by: ECO:0000000
reactant: MODEL1310110036#
name: Utilized transport
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
fast: false

metaR r0074
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
modifier: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
reversible: true

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR r2044
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_1d0f7809_8d53_4e1f_825b_9a167911bd88
boundary condition: true
name: OGDH
initial amount: NaN
constant: false
is encoded by: hsa:4967
type: Species
is: SBO:0000252
has only substance units: false
is: B4E3E9
initial concentration: NaN

metaM HC00900 c
initial amount: NaN
has only substance units: false
is: CHEBI:30860
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
name: Methylmalonate
type: Species

metaR LEUKTRA4t
type: Reaction
is described by: ECO:0000269
name: leukotriene A4 transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
reversible: true

metaM CE5236 n
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
type: Species
is: CHEBI:28002
initial amount: NaN
is: SBO:0000247
is: HMDB03952
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_e4c15d33_503a_4202_b49b_764380557115
type: Species
is: E9PNG0
constant: false
boundary condition: true
is: SBO:0000252
name: AMPD2
has only substance units: false
is encoded by: hsa:271
initial concentration: NaN
initial amount: NaN

metaM prostgd2 r
boundary condition: false
name: prostaglandin D2(1-)
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:57406
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_e5db6c50_ad07_448a_882e_6229eaef4c24
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:AI926493
name: _AI926493_1_m
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaM HC02193 c
name: glycolithocholate
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1
type: Species
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:60008
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_18199019_0a7e_4efe_98e3_cc1de4a4e500
name: NDUFB3
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4709
initial concentration: NaN
initial amount: NaN
type: Species
is: Q6IB80

metaM ps hs c
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
name: ps_hs[c]
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_b98f23ad_67cc_4f7e_9a41_f1aacf8cda1f
initial amount: NaN
type: Species
is: A8K0S7
constant: false
name: SLC37A4
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2542
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_d7a47d88_0050_40e0_bf20_9e1939f4fcef
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: PPAP2B
initial concentration: NaN
boundary condition: true
is: O14495
is encoded by: hsa:8613
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_9251df68_0ad4_41b9_9744_e7893f102b26
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AV727634
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AV727634_1_c

metaM orot c
is: HMDB00226
is: CHEBI:30839
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
name: Orotate
boundary condition: false
is: SBO:0000247
is: C00295
type: Species
initial amount: NaN
constant: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_7e0a041a_2264_4b15_9ed0_ef1635cf46b5
constant: false
name: INPP4A
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3631
initial concentration: NaN

metaR PItg
reversible: false
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: phosphate transport, Golgi apparatus
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#

metaR NICRNS
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
name: NICRNS
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaM sphs1p r
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
boundary condition: false
is: CHEBI:60119
is: HMDB00277
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_5405f863_599f_4356_8dcb_362c98fae466
name: _FLJ44968_1_m
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:FLJ44968
has only substance units: false
boundary condition: true
constant: false

metaM utp e
initial concentration: 1.0
is: HMDB00285
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
is: CHEBI:46398

MODEL1310110036
reaction: metaR r0410
reaction: metaR r1602
reaction: metaR EX cyan LPAREN e RPAREN
species: metaM malthp e
species: metaM fol c
species: metaM 13dpg c
reaction: metaR r1670
reaction: metaR ACACT1rm
reaction: metaR FAOXC6DCC4DCx
species: metaM frdp c
reaction: metaR r2338
reaction: metaR DGULND
species: metaM mi145p c
species: metaM fpram c
reaction: metaR C3STKR2r
reaction: metaR r1575
reaction: metaR r0909
reaction: metaR RE3003M
reaction: metaR RE1807C
species: metaM glyc m
reaction: metaR RE3566C
reaction: metaR r1652
species: metaM ile L c
reaction: metaR r0647
reaction: metaR r2347
reaction: metaR r0570
reaction: metaR PPAn
reaction: metaR r2521
reaction: metaR NOt
species: metaM 3mox4hoxm c
reaction: metaR FRUt4
reaction: metaR RE0944E
reaction: metaR EX ac LPAREN e RPAREN
reaction: metaR RNDR4
species: metaM dhf m
reaction: metaR r1621
reaction: metaR r0377
species: metaM gsn e
reaction: metaR 2HBO
species: metaM leuktrA4 c
species: metaM prostgf2 e
reaction: metaR GGT6
reaction: metaR r1298
species: metaM ddcacoa m
reaction: metaR CYTD
species: metaM 10fthf5glu e
reaction: metaR r0724
species: metaM ocdcea r
reaction: metaR r0384
species: metaM etoh e
reaction: metaR r1618
reaction: metaR EX o2s LPAREN e RPAREN
reaction: metaR MALSO3tm
species: metaM i c
reaction: metaR LEULEULAPc
species: metaM crm hs r
reaction: metaR LEUKTRB4t
species: metaM 3pg c
reaction: metaR r0973
species: metaM prostge1 e
species: metaM itp n
species: metaM odecoa m
reaction: metaR FAOXC140
reaction: metaR r0423
reaction: metaR KHte
species: metaM dudp n
species: metaM ump c
reaction: metaR r1612
reaction: metaR ADNt
reaction: metaR PROSTGF2t
reaction: metaR RE1532M
reaction: metaR r0614
reaction: metaR EX nh4 LPAREN e RPAREN
reaction: metaR r1117
reaction: metaR LCADi
species: metaM gumtchol e
species: metaM g1p c
species: metaM dhf e
reaction: metaR HSD3B7P
reaction: metaR FACOAL80i

metaR r2310
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction

metaR TYRTA
reversible: true
modifier: MODEL1310110036#
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000176
product: MODEL1310110036#
is described by: ECO:0000269
type: Reaction

metaM HC00342 c
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
name: cis-aconitate(3-)
type: Species
is: CHEBI:16383
initial amount: NaN
boundary condition: false

metaM CE0785 m
has only substance units: false
name: cis,cis-myristo-5,8-dienoyl-CoA
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: CHEBI:57795
initial concentration: 1.0
boundary condition: false

metaR PALFATPtc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_22498510_f8d3_4dc1_875a_c0ea766e1c37
has only substance units: false
is: P10696
name: ALPPL2
initial amount: NaN
is encoded by: hsa:251
type: Species
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR ACOAD1fm
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110036#_7cba6bda_0303_4487_9cf0_a6568a9a7282
name: ALDH4A1
is encoded by: hsa:8659
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: P30038
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_19201e76_5533_425f_a9d2_78cb54bbeb9e
boundary condition: true
is encoded by: hsa:197257
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q86WU2
constant: false
name: LDHD

metaM nadph c
type: Species
constant: false
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
is: C00005
is: HMDB00221
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_d0cebb51_7d59_4c69_a9a2_8cb7c7cb689e
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:54995
is: Q9NWU1
is: SBO:0000252
boundary condition: true
has only substance units: false
name: OXSM
constant: false
type: Species

metaR HSD17B42x
name: hydroxysteroid (17-beta) dehydrogenase 4
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110036#
reversible: false
product: MODEL1310110036#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use

metaM atp m
name: ATP(4-)
type: Species
is: HMDB00538
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00002
constant: false
is: CHEBI:57299
initial concentration: 1.0
has only substance units: false

metaR r2311
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110036#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110036#_942d1b07_43a5_4d0b_899f_778b29ce0e9e
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: LEFTY1
is: O75610
is encoded by: hsa:10637

metaR DMATTx
reactant: MODEL1310110036#
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.1
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
name: dimethylallyltranstransferase
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_964e15c1_0dd9_4b1a_984c_892b40d4fe92
initial amount: NaN
has only substance units: false
is: P26439
constant: false
name: HSD3B2
initial concentration: NaN
is encoded by: hsa:3284
type: Species
is: SBO:0000252
boundary condition: true

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR TYRt
name: L-tyrosine transport
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
fast: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_e57cea97_fd85_4416_98ad_a508f7ae28a9
type: Species
name: KHK
is: SBO:0000252
is encoded by: hsa:3795
is: Q6IBK2
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaM fgam c
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: SBO:0000247
boundary condition: false
is: HMDB01308
is: C04376
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:58426
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a95fad34_bb28_4b86_b755_d4e9ec7b9439
is: SBO:0000252
initial concentration: NaN
name: MLYCD
has only substance units: false
constant: false
is: O95822
initial amount: NaN
is encoded by: hsa:23417
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_bb74a79f_0020_47dd_9086_6892da83f388
is: SBO:0000252
name: ACOT7
is encoded by: hsa:11332
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: O00154

http://identifiers.org/biomodels.db/MODEL1310110036#_491ed839_b4b2_43d3_b9cd_3f25387b435b
is: P00352
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:216
has only substance units: false
name: ALDH1A1
boundary condition: true

metaM dag hs c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:18035
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
type: Species
initial amount: NaN
has only substance units: false

metaM atp n
is: CHEBI:57299
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: ATP(3-)
has only substance units: false
type: Species
is: HMDB00538
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: SBO:0000247

metaM ps hs e
constant: false
is: CHEBI:18303
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
name: phosphatidylserine
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0

metaR FUMtm
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110036#
is: SBO:0000185
type: Reaction
name: fumarate transport, mitochondrial
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_6a632c55_4241_499b_af36_e5cb4512c1c4
has only substance units: false
name: SLC7A8:SLC3A2
is encoded by: hsa:23428
constant: false
type: Species
is: SBO:0000297
has part: Q9UHI5
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM dhor S c
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:30864
name: (S)-dihydroorotate
type: Species
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
is: HMDB03349

http://identifiers.org/biomodels.db/MODEL1310110036#_eb2246be_755e_41bf_bf48_ea0aed90810e
type: Species
is: Q9NY65
is encoded by: hsa:1962
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: EHHADH
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_81a784ee_d33f_42b1_b198_7963a490ff75
name: VNN3:VNN2:VNN1
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000297
constant: false
is encoded by: hsa:8875
has part: O95497
initial amount: NaN
is encoded by: hsa:55350
has part: A8K7W0
initial concentration: NaN
is encoded by: hsa:8876

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR RE0935E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
fast: false
is described by: ECO:0000000
name: RE0935
product: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaM amet r
is: HMDB01185
is: SBO:0000247
is: CHEBI:15414
constant: false
initial concentration: 1.0
name: S-adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

metaR NDPK7n
type: Reaction
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
modifier: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110036#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

metaR D3AIBTm
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
product: MODEL1310110036#

metaR PE HSter
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_4b2f565e_d214_4d18_8cc4_40edd86a8244
type: Species
is: SBO:0000252
is encoded by: hsa:1719
constant: false
initial amount: NaN
name: DHFR
initial concentration: NaN
boundary condition: true
is: P00374
has only substance units: false

metaM co2 x
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16526
is: HMDB01967
constant: false
has only substance units: false
type: Species
name: carbon dioxide
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_6caafed5_c8dd_4098_94b5_0437bfb079cf
has only substance units: false
is encoded by: hsa:2181
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: B3KMA6
boundary condition: true
name: ACSL3
constant: false

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_0d9b6118_b0b3_4e5b_b496_bbab548a26d6
type: Species
constant: false
is encoded by: hsa:26330
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: GAPDHS
is: O14556

metaR FAOXC16DCr
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR THRGLNexR
fast: false
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b4f8a5e2_6891_4565_9363_4d571bb18bf1
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: COX4I1
type: Species
is: P13073
has only substance units: false
is encoded by: hsa:1327

metaM dump c
is: CHEBI:246422
name: dUMP
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial amount: NaN
constant: false
has only substance units: false
is: C00365
type: Species
is: HMDB01409
boundary condition: false

metaR LTD4DP
is described by: ECO:0000000
name: Leukotriene D4 dipeptidase
fast: false
reactant: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
is: SBO:0000176
product: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM dctp c
is: CHEBI:16311
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
is: SBO:0000247
is: HMDB00998
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

metaR r0630
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.3.2
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.3.1
reversible: true

metaR NDPK10n
product: MODEL1310110036#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
fast: false
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reversible: true

metaR PROSTGF2t
reactant: MODEL1310110036#
name: prostaglandin uniport
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000269
product: MODEL1310110036#
modifier: MODEL1310110036#
fast: false

metaR DM T antigen g
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_63c0e4d5_c125_4702_86da_82df8344decc
initial concentration: NaN
has only substance units: false
is encoded by: hsa:27232
constant: false
type: Species
name: GNMT
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q14749

metaM pail hs n
is: CHEBI:57880
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_5d849786_73ec_4a96_a965_cab2afced073
is: SBO:0000252
constant: false
is encoded by: hsa:3948
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P07864
has only substance units: false
type: Species
name: LDHC

metaM gd3 hs g
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
initial amount: NaN
name: GD3
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28424

metaR ORNDC
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
is version of: http://identifiers.org/ec-code/4.1.1.17
name: Ornithine Decarboxylase
product: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_fa389094_b01f_4467_8ac1_966bb7dcb18b
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: LDHAL6B
constant: false
is: Q9BYZ2
is encoded by: hsa:92483
initial amount: NaN

metaR ABUTD
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is described by: ECO:0000269
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
name: Aminobutyraldehyde dehydrogenase
modifier: MODEL1310110036#
type: Reaction

metaM pristcoa c
type: Species
name: pristanoyl coa
initial concentration: 1.0
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
constant: false
initial amount: NaN
is: CHEBI:51341
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f164c6da_9809_40b8_8edc_c989d62d4b03
name: ASRGL1
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80150
is: SBO:0000252
type: Species
boundary condition: true
is: Q7L266
has only substance units: false

metaR r0509
is described by: ECO:0000000
reactant: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
fast: false
product: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
type: Reaction

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR r2497
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is described by: ECO:0000000

metaM utp c
constant: false
has only substance units: false
is: CHEBI:46398
type: Species
boundary condition: false
name: UTP
is: HMDB00285
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: SBO:0000247
is: C00075
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_84eeb3ef_a80e_4f55_928e_4a426e00c5ee
is: O00400
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9197
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: SLC33A1

metaM cholp g
name: choline phosphate(1-)
constant: false
initial amount: NaN
is: C00588
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
type: Species
is: CHEBI:295975

metaR TSTSTERONEt
type: Reaction
product: MODEL1310110036#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
reactant: MODEL1310110036#
fast: false
name: Testosterone transport

http://identifiers.org/biomodels.db/MODEL1310110036#_387edbad_0ada_406d_af16_9f69b636dd08
initial amount: NaN
name: _AI924226_1_m
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI924226
boundary condition: true
type: Species
constant: false
initial concentration: NaN

metaM na1 r
type: Species
constant: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
is: HMDB00588
initial concentration: 1.0
is: CHEBI:29101
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: sodium(1+)

metaR HIStiDF
reversible: false
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000269
name: L-histidine transport via diffusion (extracellular to cytosol)
product: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_9a82786f_d92b_4d13_93ae_d0a2a06f6186
initial amount: NaN
is encoded by: hsa:5214
constant: false
name: PFKP
initial concentration: NaN
is: Q5VSR7
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_cc579438_3f1d_4def_8fa8_0be01c488a98
name: AMY1B
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is: P04745
initial amount: NaN
is encoded by: hsa:277
boundary condition: true

metaM sql r
boundary condition: false
is: CHEBI:15440
initial amount: NaN
type: Species
constant: false
name: squalene
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: HMDB00256
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_a76230a5_9c9f_43b2_8f02_4fe259deb71d
constant: false
boundary condition: true
initial amount: NaN
name: FH
type: Species
initial concentration: NaN
is: P07954
has only substance units: false
is encoded by: hsa:2271
is: SBO:0000252

metaM HC00250 e
name: hydrosulfide
boundary condition: false
initial concentration: 1.0
is: CHEBI:29919
type: Species
has only substance units: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
constant: false
is: SBO:0000247

metaM dhf m
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056
name: dihydrofolate(2-)
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0

metaR RE1233C
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is: SBO:0000176
reversible: true
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
name: RE1233
product: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110036#

metaR FAOXC16C14x
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)x
type: Reaction

metaM cl e
name: Chloride
is: CHEBI:3966
is: HMDB00492
initial amount: NaN
has only substance units: false
is: C00115
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
boundary condition: false
type: Species

metaR r1813
fast: false
is: SBO:0000185
reactant: MODEL1310110036#
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR THRD L
product: MODEL1310110036#
is described by: ECO:0000269
modifier: MODEL1310110036#
reversible: false
fast: false
name: L-threonine deaminase
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.3.1.17
is: SBO:0000176

metaM xylu D c
name: D-xylulose
is: SBO:0000247
is: HMDB01644
is: CHEBI:17140
constant: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_42de5b6c_8362_4f04_92e3_59cc03541c1b
initial concentration: NaN
is: Q99944
type: Species
has only substance units: false
name: EGFL8
is encoded by: hsa:80864
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM HC01603 c
is: SBO:0000247
is: C00234
constant: false
is: CHEBI:57454
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0

metaR CYTK11n
reversible: true
fast: false
is: SBO:0000176
name: cytidylate kinase (dCMP,dGTP),nuclear
product: MODEL1310110036#
is described by: ECO:0000269
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_97c660f7_c210_47e4_ac70_4f7996541854
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
name: _NOS2A_1_c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:NOS2A

http://identifiers.org/biomodels.db/MODEL1310110036#_ecdc6a17_45ce_4edb_a5cb_25c62fbfe37d
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:5290
initial concentration: NaN
has only substance units: false
is: P42336
boundary condition: true
initial amount: NaN
name: PIK3CA

metaR 2HBt2
reversible: true
type: Reaction
fast: false
name: 2-hydroxybutyrate cotransport with proton
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#

metaR r1527
fast: false
is: SBO:0000185
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.1
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
reversible: false
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR r0842
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is: SBO:0000185
modifier: MODEL1310110036#
is described by: ECO:0000000
name: Postulated transport reaction
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_b5f196f7_b887_4668_8aa5_644c6980a6eb
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: NDUFS4
constant: false
is: O43181
initial amount: NaN
boundary condition: true
is encoded by: hsa:4724

metaR r0093
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
fast: false
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.1.3
reactant: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_562d7105_e45e_465f_ade3_12049f9dcf1c
boundary condition: true
constant: false
initial concentration: NaN
is: P31040
has only substance units: false
name: SDHA
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:6389

metaM guln c
has only substance units: false
is: HMDB03290
boundary condition: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
constant: false
initial amount: NaN
is: CHEBI:13115
is: SBO:0000247
initial concentration: 1.0
name: L-gulonate
type: Species

metaM dcyt e
is: C00881
is: HMDB00014
is: SBO:0000247
is: CHEBI:15698
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
initial amount: NaN
name: Deoxycytidine
has only substance units: false

metaM h2o2 x
name: Hydrogen peroxide
is: C00027
has only substance units: false
initial amount: NaN
is: CHEBI:16240
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

http://identifiers.org/biomodels.db/MODEL1310110036#_e2935435_7970_46a5_84a9_8b1f046da17a
has only substance units: false
name: SGMS1
initial amount: NaN
boundary condition: true
is: D3DWC4
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:259230
constant: false

metaR RE1845X
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
type: Reaction
modifier: MODEL1310110036#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: RE1845
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110036#

metaR CYTD
is version of: http://identifiers.org/ec-code/3.5.4.5
type: Reaction
modifier: MODEL1310110036#
name: cytidine deaminase
is: SBO:0000176
product: MODEL1310110036#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110036#_9b328d87_c868_4c98_b3c1_65151c779af8
name: COX6C
boundary condition: true
is encoded by: hsa:1345
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: P09669

metaM HC02214 e
is: CHEBI:28852
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: prostaglandin-f1alpha

http://identifiers.org/biomodels.db/MODEL1310110036#_19c0e138_209b_4118_9781_3211680d408f
constant: false
boundary condition: true
name: COX7A1
is encoded by: hsa:1346
initial concentration: NaN
is: P24310
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_a7a19f41_08d7_4429_9ff8_ffb1e5374575
name: MTMR1
is: Q13613
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:8776
is: SBO:0000252
constant: false
initial amount: NaN

metaM glc D r
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
name: D-glucose
is: SBO:0000247
is: HMDB00122
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:4167
initial amount: NaN

metaM hdd2coa m
name: trans-Hexadec-2-enoyl-CoA
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
boundary condition: false
type: Species
is: HMDB03945
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_c3371e46_4ed4_46ad_95ba_34a367dd12a8
is encoded by: hsa:3155
is: Q6IBC0
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: HMGCL
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_c1394618_747d_4f7c_a562_1023be8d6543
is encoded by: hsa:8871
is: SBO:0000252
name: SYNJ2
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: O15056

http://identifiers.org/biomodels.db/MODEL1310110036#_5cf303c6_39a5_486e_a9bd_bb6c99312016
name: DEGS1
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:8560
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_c3cb22ee_ba28_49dd_ae05_4f222cdd8c81
has only substance units: false
is: Q709F0
is encoded by: hsa:84129
is: SBO:0000252
initial concentration: NaN
name: ACAD11
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaR r0596
reactant: MODEL1310110036#
is: SBO:0000176
type: Reaction
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
fast: false
kinetic law: MODEL1310110036#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_6f35110c_630d_4aca_9d08_4c9300c4cd9a
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:212
constant: false
initial amount: NaN
type: Species
name: ALAS2
is: Q5JZF5

metaR r2308
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
product: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_67b99c78_9f0f_4c08_8845_d957ccc9e9c0
is encoded by: hsa:4715
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: NDUFB9
boundary condition: true
constant: false
is: Q9Y6M9

http://identifiers.org/biomodels.db/MODEL1310110036#_660c360f_c11c_4096_b852_0020f62997a4
boundary condition: true
is: P41222
is encoded by: hsa:5730
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: PTGDS

metaR r2410
reversible: false
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_acbf22ab_15f4_4144_a068_bd7add13cb1f
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:4830
type: Species
has part: P22392
is encoded by: hsa:4831
has part: P15531
name: NME1:NME2

metaR r0634
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.4.1
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
type: Reaction

metaR H2Ot
kinetic law: MODEL1310110036#
is described by: ECO:0000269
fast: false
reversible: true
name: H2O transport via diffusion
product: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
reactant: MODEL1310110036#

metaR L LACDcm
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
reactant: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false

metaR 1PPDCRp
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
product: MODEL1310110036#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
is: SBO:0000176

metaR PI45P4P
fast: false
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reactant: MODEL1310110036#
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110036#_59b318e8_0107_4c18_90f3_1c9dd61c8b0e
constant: false
boundary condition: true
is encoded by: hsa:23632
is: A8K3J4
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: CA14

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR BUTt2r
modifier: MODEL1310110036#
reversible: true
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
name: Butyrate transport via proton symport, reversible
reactant: MODEL1310110036#
type: Reaction

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM dcyt c
type: Species
is: C00881
initial concentration: 1.0
is: HMDB00014
is: SBO:0000247
boundary condition: false
is: CHEBI:15698
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: Deoxycytidine
has only substance units: false
constant: false
initial amount: NaN

metaR RE1516M
is: SBO:0000176
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
kinetic law: MODEL1310110036#
name: RE1516
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR NODe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
fast: false
name: NODe
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110036#
reversible: true

metaR RE1521M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1521
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
type: Reaction
modifier: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false

metaR NTD7
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (AMP)
product: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
reversible: false

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaM dhcholestanate c
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
has only substance units: false
is: SBO:0000247
is: CHEBI:16577
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00359

metaM malthx e
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: C01936
initial amount: NaN
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: SBO:0000247
name: Maltohexaose
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false

metaR DTDPtn
is: SBO:0000185
type: Reaction
name: dTDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#

metaR PAPtg
reversible: false
is: SBO:0000185
product: MODEL1310110036#
is described by: ECO:0000000
name: adenosine 3',5'-bisphosphate Golgi transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction

metaR r0909
product: MODEL1310110036#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
kinetic law: MODEL1310110036#
type: Reaction
name: Transport reaction
is: SBO:0000185
reactant: MODEL1310110036#

metaM HC01231 c
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58480
is: SBO:0000247
type: Species
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_1438301b_5003_4b80_abcf_0f6aea2bade3
boundary condition: true
is: SBO:0000252
type: Species
name: SCD
has only substance units: false
is: O00767
constant: false
initial amount: NaN
is encoded by: hsa:6319
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_6f77b9c9_7d58_4ef9_a0f5_230dcee234ca
is: SBO:0000252
is encoded by: hsa:84569
initial concentration: NaN
constant: false
name: LYZL1
has only substance units: false
is: Q6UWQ5
boundary condition: true
type: Species
initial amount: NaN

metaR CERT2rt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110036#
name: ceramide transport protein
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
modifier: MODEL1310110036#
reversible: true
product: MODEL1310110036#
reactant: MODEL1310110036#

metaM cholcoads x
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
is: SBO:0000247
initial amount: NaN
is: CHEBI:27505
is: HMDB06889
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

metaR CDS
type: Reaction
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
name: phosphatidate cytidylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.41
product: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
is: SBO:0000176
reversible: false
modifier: MODEL1310110036#

metaR PTCRTD
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
type: Reaction
name: diffusion of putriscine into the endothelial cells
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
fast: false
is: SBO:0000185
product: MODEL1310110036#
is described by: ECO:0000134

metaR RE1254C
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
name: RE1254
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:

metaM udpg c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: C00029
is: CHEBI:58367
is: HMDB00286
name: UDPglucose
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_89cce495_7755_4b1f_ba3b_26817de464fd
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: P53794
is: SBO:0000252
has only substance units: false
type: Species
name: SLC5A3
is encoded by: hsa:6526

metaR r0908
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110036#
name: Postulated transport reaction
product: MODEL1310110036#

metaR DHPM1
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.2.2
is described by: ECO:0000269
modifier: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
name: dihydropyrimidinase (5,6-dihydrouracil)

metaM man1p c
is: CHEBI:35374
is: SBO:0000247
type: Species
constant: false
is: HMDB06330
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_6fa3787a_0f65_450b_a990_f587b5adeba8
initial concentration: NaN
has only substance units: false
name: GGT5
constant: false
is: SBO:0000252
type: Species
is: P36269
boundary condition: true
initial amount: NaN
is encoded by: hsa:2687

http://identifiers.org/biomodels.db/MODEL1310110036#_8e25cf1c_8521_4c09_babb_b04572e2f465
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3418
name: IDH2
is: P48735
constant: false
type: Species

metaR UMPK6n
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110036#
type: Reaction
name: UMP kinase (dCTP),nuclear
reversible: true

metaR r0504
reversible: true
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is version of: http://identifiers.org/ec-code/2.3.3.10
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000000

metaR r0633
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.3
modifier: MODEL1310110036#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR NH4tn
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: true
name: ammonia nuclear transport

metaM cl c
name: Chloride
type: Species
has only substance units: false
is: CHEBI:3966
is: HMDB00492
initial concentration: 1.0
is: C00115
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: Cl CHARGE: -1

metaR 4MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110036#
reversible: true
name: Transport of 4-methyl-2-oxopentanoate
reactant: MODEL1310110036#
is described by: ECO:0000134
fast: false
type: Reaction
product: MODEL1310110036#
is: SBO:0000185

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM galside hs c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine
boundary condition: false
has only substance units: false
is: CHEBI:12947
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_46856a0e_5fd2_4f57_b7f7_e6f80b461c72
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: NME1:NME2
is: SBO:0000297
constant: false
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110036#_bc9d9758_5f4a_4682_8fb0_7eca39c27eb7
type: Species
is: SBO:0000252
name: CDS1
is encoded by: hsa:1040
is: Q92903
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaM HC01231 m
is: SBO:0000247
boundary condition: false
is: CHEBI:58480
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate

metaR ILEt5m
name: Isoleucine mitochondrial transport
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_78e2e6ef_ac33_4c00_85bf_3851695c8ddd
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:100287639
type: Species
name: _100287639_1_c

http://identifiers.org/biomodels.db/MODEL1310110036#_794bb3f8_a912_49fc_8c9d_b76b333b0e62
is encoded by: hsa:1375
type: Species
boundary condition: true
is: Q92523
constant: false
name: CPT1B
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1b2bf50f_0d62_43c1_9b02_0434e6e5d40b
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:H17063
name: _H17063_1_c
boundary condition: true
is: SBO:0000252

metaM udpg e
boundary condition: false
is: HMDB00286
has only substance units: false
is: CHEBI:58367
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species

metaM 34dhpac c
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
initial concentration: 1.0
is: HMDB03791
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:27978
constant: false
is: SBO:0000247
name: 3,4-Dihydroxyphenylacetaldehyde

metaR r0743
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reversible: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110036#
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
reactant: MODEL1310110036#
type: Reaction

metaR RE1810M
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000176
name: RE1810
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction

metaM fad e
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
is: CHEBI:16238
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
is: C00016

metaR ALR3
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
name: aldose reductase (acetol)
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2

metaR RE1527M
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
name: RE1527
fast: false

metaR BTNt2
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
type: Reaction
name: Biotin reversible transport via proton symport
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110036#_b5b52574_f183_4765_8c50_0e4808fe5aa2
has only substance units: false
name: NME1
is: P15531
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4830
type: Species
constant: false

metaM dhap x
has only substance units: false
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false
initial concentration: 1.0
is: CHEBI:57642
is: SBO:0000247
type: Species
name: Dihydroxyacetone phosphate
is: C00111
is: HMDB01473
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_6b85df6f_53a2_43d8_80f9_1503f5d298b4
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: B3KT84
is encoded by: hsa:195814
name: SDR16C5
initial amount: NaN

metaR r0365
reversible: false
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR PIt8
is described by: ECO:0000006
product: MODEL1310110036#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000185
name: phosphate transport in/out via Na+ symporter
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_f9bd92fe_b846_419a_b1d6_7693e86f846f
is: SBO:0000252
constant: false
is encoded by: hsa:10455
initial concentration: NaN
has only substance units: false
is: O75521
type: Species
boundary condition: true
name: ECI2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_f05b2acc_6084_4cb9_946b_d5db3a10467d
is: P14060
is: SBO:0000252
is encoded by: hsa:3283
type: Species
constant: false
boundary condition: true
name: HSD3B1
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM anth c
constant: false
has only substance units: false
is: CHEBI:16567
is: HMDB01123
is: SBO:0000247
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
name: anthranilate
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_8b6aa6a1_059c_4184_9bcc_853bbafe9935
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: NT5C1B
is: SBO:0000252
has only substance units: false
is encoded by: hsa:93034
is: B3KUK6

metaM galside hs e
boundary condition: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110036#_cd2d0249_b321_4f24_bf93_a30e1954f915
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: GK3P
has only substance units: false
is encoded by: hsa:2713
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_68c3202d_7f49_4195_8636_b57192bee221
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10423
is: A8K3L7
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: CDIPT
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_d5c942e0_50ab_4e55_9766_04c6ca858c79
name: CA4
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:762
constant: false
type: Species
is: Q6FHI7

metaM HC01459 x
boundary condition: false
constant: false
is: CHEBI:27458
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_d63edba1_ad26_4b0a_8b55_ccb4ccf33a37
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: MTMR3
is encoded by: hsa:8897
constant: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_5b26364e_676a_42b5_8984_e8cd6ad8a9e7
constant: false
name: GOT1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2805
initial concentration: NaN
is: P17174
initial amount: NaN
boundary condition: true
type: Species

metaR r2520
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185
product: MODEL1310110036#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:

metaR r0744
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110036#
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
type: Reaction
fast: false

metaR GGH 5DHFe
kinetic law: MODEL1310110036#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110036#
reversible: false
product: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_92ce57a0_aabc_4d46_9635_eab6c4a42b29
boundary condition: true
type: Species
initial amount: NaN
is: Q13057
is encoded by: hsa:80347
has only substance units: false
name: COASY
is: SBO:0000252
initial concentration: NaN
constant: false

metaM aicar c
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: C04677
initial amount: NaN
boundary condition: false
is: CHEBI:58475
type: Species
is: HMDB01517
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_e56b46d1_367c_42a0_9bb4_6d8cdfbe3196
is: F8WDN9
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PPA2
is encoded by: hsa:27068
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_e4d16ffe_57b9_4b0b_8af4_236631435ca0
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:284111
type: Species
boundary condition: true
name: SLC13A5
initial amount: NaN
has only substance units: false
is: Q86YT5

metaR DADA
is: SBO:0000176
product: MODEL1310110036#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.4
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
reversible: false
name: Deoxyadenosine deaminase
type: Reaction
modifier: MODEL1310110036#
reactant: MODEL1310110036#

metaR r1464
kinetic law: MODEL1310110036#
name: Active transport
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b1b79e0e_c3f7_4acc_84dd_fe80aac38c4b
initial amount: NaN
constant: false
is encoded by: hsa:5130
type: Species
is: SBO:0000252
boundary condition: true
is: P49585
initial concentration: NaN
name: PCYT1A
has only substance units: false

metaR PIt7
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
reversible: true
name: phosphate transport in/out via three Na+ symporter
is described by: ECO:0000269
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
fast: false

metaM prostgh2 e
type: Species
is: HMDB01381
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: CHEBI:57405
initial concentration: 1.0
name: prostaglandin H2(1-)

metaR It
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
product: MODEL1310110036#
name: Iodide uniport
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
fast: false

metaM CE1944 c
constant: false
is: SBO:0000247
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
type: Species
initial concentration: 1.0
is: CHEBI:36781
initial amount: NaN
boundary condition: false
name: 1-pyrrolinium
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_080c78d9_0106_4630_9d4c_ad3ca5192fad
name: OGDH
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4967
is: Q02218
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_4fe66239_1f42_4035_a394_93f8523c7556
boundary condition: true
name: RDH14
is encoded by: hsa:57665
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9HBH5
has only substance units: false
is: SBO:0000252
constant: false

metaM fad c
initial amount: NaN
is: C00016
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
has only substance units: false
is: CHEBI:16238
is: HMDB01248
boundary condition: false
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
constant: false
is: SBO:0000247

metaM nadp x
is: C00006
is: CHEBI:58349
has only substance units: false
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217

http://identifiers.org/biomodels.db/MODEL1310110036#_a535c530_c8ef_417d_a092_45beafc274ee
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1836
boundary condition: true
is: P50443
constant: false
type: Species
has only substance units: false
name: SLC26A2
initial concentration: NaN

metaR r2521
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
name: Utilized transport
reactant: MODEL1310110036#
fast: false

metaR GGT6
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
name: Gamma-glutamyltransferase
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ

http://identifiers.org/biomodels.db/MODEL1310110036#_7ac5ddbc_9573_402f_a5c5_3cbe38d3e59c
initial amount: NaN
boundary condition: true
type: Species
name: IK
constant: false
has only substance units: false
is: Q13123
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3550

http://identifiers.org/biomodels.db/MODEL1310110036#_f0c3e9ff_3fe4_4457_837b_21570836259b
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: SLC26A1
is encoded by: hsa:10861
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_3788495f_5b5b_4200_a373_07db60072407
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2618
constant: false
is: P22102
initial concentration: NaN
name: GART
initial amount: NaN
boundary condition: true
type: Species

metaR r0441
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
reactant: MODEL1310110036#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
modifier: MODEL1310110036#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaR RE1532M
name: RE1532
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
fast: false

metaR Uritm
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
type: Reaction
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000185
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: uridine facilated transport in mitochondria

metaR DHCRD2
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000269
reactant: MODEL1310110036#
reversible: false
name: dihydroceramide desaturase
is: SBO:0000176
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_c30c33a5_1e89_4357_9402_c08d777bafab
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is: P82251
type: Species
is encoded by: hsa:11136
has only substance units: false
name: SLC7A9
boundary condition: true

metaR r0741
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
fast: false
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR LNLCCRNt
reactant: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110036#
reversible: false
product: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_be0e14bb_1538_4b1f_a48a_6fc4367111c9
constant: false
name: PIP5K1A
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:8394
is: Q99755
has only substance units: false

metaM h2o x
boundary condition: false
name: H2O
is: HMDB02111
is: C00001
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
is: CHEBI:15377
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_41d5d61f_b88d_4474_908a_5840147feafb
constant: false
type: Species
is: O60312
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:57194
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ATP10A

metaM galside hs g
constant: false
has only substance units: false
is: CHEBI:12947
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
type: Species
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
boundary condition: false

metaR RE3269C
name: RE3269
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
is version of: http://identifiers.org/ec-code/3.1.3.48

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM r1p c
constant: false
type: Species
name: alpha-D-Ribose 1-phosphate
is: HMDB01489
is: CHEBI:57720
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
initial concentration: 1.0
has only substance units: false
is: C00442
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_bdf96227_6633_4acd_89ac_138ec85fe9d6
is encoded by: hsa:80270
initial amount: NaN
has only substance units: false
name: HSD3B7
is: Q9H2F3
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaR EX gumtchol LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-taurocholic acid complex
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1b7c9c92_86e1_405c_9649_5826fd89271c
is encoded by: hsa:29988
initial amount: NaN
is: SBO:0000252
is: Q9NY64
initial concentration: NaN
constant: false
name: SLC2A8
boundary condition: true
has only substance units: false
type: Species

metaM aicar e
type: Species
initial amount: NaN
is: SBO:0000247
is: C04677
constant: false
notes: FORMULA: C9H13N4O8P CHARGE: -2
has only substance units: false
is: HMDB01517
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_e922bfc5_f3e9_4b51_8ff3_9933c3083ccb
is: Q546H9
constant: false
has only substance units: false
name: ALDH5A1
is encoded by: hsa:7915
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR TRPHYDRO2
is: SBO:0000176
reactant: MODEL1310110036#
reversible: false
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.14.16.4
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
is described by: ECO:0000269

metaM CE2433 m
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
is: CHEBI:57795
is: SBO:0000247

metaR RPEc
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
kinetic law: MODEL1310110036#
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110036#
name: ribulose 5-phosphate 3-epimerase

http://identifiers.org/biomodels.db/MODEL1310110036#_57adf84e_f29d_4024_912d_d76562129c10
is: P04746
name: AMY2A
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:279
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM prostgh2 c
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
is: SBO:0000247
is: CHEBI:57405
constant: false
type: Species
has only substance units: false
name: prostaglandin H2(1-)
is: HMDB01381
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_c3f196a0_0938_4cb6_b496_c0267468bc31
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8612
initial amount: NaN
is: E9PAY8
constant: false
name: PPAP2C
is: SBO:0000252
boundary condition: true

metaR HMGCOAtx
is: SBO:0000185
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_edf89e94_848c_48d4_870f_3730eb633f56
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: _AI824319_1_r
boundary condition: true
is encoded by: hsa:AI824319
has only substance units: false

metaM h2o r
initial amount: NaN
constant: false
is: HMDB02111
is: C00001
name: H2O
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:15377
initial concentration: 1.0

metaM dcsptn1coa c
initial concentration: 1.0
is: C16173
type: Species
is: HMDB06513
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaM prostgi2 c
initial concentration: 1.0
is: HMDB01335
is: CHEBI:57403
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
name: prostaglandin I2(1-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_2ab98d6c_79bc_4713_94bd_930834c3bbc0
initial amount: NaN
name: AHCY
is: SBO:0000252
is: B3KUN3
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:191
has only substance units: false

metaM retinol c
is: CHEBI:50211
has only substance units: false
name: retinol
initial concentration: 1.0
is: SBO:0000247
is: HMDB00305
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
constant: false
boundary condition: false

metaR CYTK9n
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
is described by: ECO:0000269
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: cytidylate kinase (CMP,dCTP),nuclear
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_0a9a47e7_d1ac_4505_8e8d_706b3149d5a6
is: Q96CD2
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:60490
constant: false
is: SBO:0000252
name: PPCDC
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_99fac40d_1ac0_414a_bccf_6f7b434fad0a
boundary condition: true
name: _AU149534_1_m
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AU149534
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_ac81bbd0_06cb_4bd5_9215_250f14e77d53
boundary condition: true
type: Species
name: NT5M
is encoded by: hsa:56953
initial amount: NaN
is: SBO:0000252
is: Q9NPB1
constant: false
has only substance units: false
initial concentration: NaN

metaR r0443
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
modifier: MODEL1310110036#
reactant: MODEL1310110036#
fast: false

metaR r1672
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
fast: false
is: SBO:0000185
product: MODEL1310110036#
modifier: MODEL1310110036#
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000

metaR DNDPt14m
modifier: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110036#
reversible: false
type: Reaction
name: dUDP transport via dTDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110036#

metaM C02528 c
initial amount: NaN
constant: false
type: Species
is: HMDB00518
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: SBO:0000247
boundary condition: false
name: chenodeoxycholate
initial concentration: 1.0
is: CHEBI:36234

metaM spc hs c
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: sphingosylphosphorylcholine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: http://identifiers.org/pubchem.compound/5311445
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_7a3b25a0_5171_4c44_b3b6_6139526f9aa8
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110036#_9bca4bea_13dc_4a86_bf18_db2ab8df170c
has only substance units: false
type: Species
initial concentration: NaN
is: P56556
constant: false
is encoded by: hsa:4700
boundary condition: true
name: NDUFA6
initial amount: NaN
is: SBO:0000252

metaR MMCDm
is described by: ECO:0000212
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.9
reactant: MODEL1310110036#
type: Reaction
name: Methylmalonyl-CoA decarboxylase, mitochondrial
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD

metaR OCTAt
fast: false
name: Octanoate transport via diffusion
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_0a1ce33b_ced9_480c_8d2d_04a409ed25bf
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5313
has only substance units: false
type: Species
name: PKLR
boundary condition: true
initial concentration: NaN

metaR r0954
reversible: true
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
kinetic law: MODEL1310110036#
name: MCT 1 Transport reaction
is: SBO:0000185
fast: false

metaM dudp c
is: C01346
is: CHEBI:60471
is: SBO:0000247
initial concentration: 1.0
is: HMDB01000
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
name: dUDP
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_383756af_c51c_4552_a684_53136fa5a199
is: SBO:0000252
initial concentration: NaN
name: COX7A2
constant: false
initial amount: NaN
is encoded by: hsa:1347
boundary condition: true
is: H0UI06
has only substance units: false
type: Species

metaM e4p c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16897
constant: false
type: Species
is: C00279
is: HMDB01321
initial amount: NaN
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
name: D-Erythrose 4-phosphate
is: SBO:0000247

metaM amet c
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
type: Species
is: C00019
initial concentration: 1.0
name: S-Adenosyl-L-methionine
is: CHEBI:15414
is: HMDB01185
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaR r0157
modifier: MODEL1310110036#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is: SBO:0000176
product: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.2
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
kinetic law: MODEL1310110036#

metaM 3mop m
type: Species
is: SBO:0000247
is: CHEBI:28654
initial concentration: 1.0
initial amount: NaN
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
boundary condition: false
has only substance units: false
name: 3-methyl-2-oxopentanoate
constant: false

metaR DCYTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
fast: false
name: deoxycytidine transport via diffusion
is described by: ECO:0000000

metaR ACACt2m
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000269
name: Acetoacetate mitochondrial transport via H+ symport
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD

metaR r2419
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110036#

metaM fol c
is: SBO:0000247
is: HMDB00121
type: Species
has only substance units: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Folate
constant: false

metaR PRAGSr
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110036#
name: phosphoribosylglycinamide synthase
type: Reaction

metaR RE2799C
is described by: ECO:0000000
reversible: true
name: RE2799
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000176
fast: false

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaM mev R x
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00227
constant: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: CHEBI:36464
initial concentration: 1.0
name: (R)-mevalonate
boundary condition: false

metaR P45027A1m
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
fast: false
name: Cytochrome P450 27
is: SBO:0000176
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_712c05b1_70bd_4c48_9557_601e98f97bb2
boundary condition: true
name: TPH1
is: P17752
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:7166
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_e2ce2927_b8a9_43f5_83e6_bcaedb1af004
name: CHKB
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:1120
is: Q9Y259
has only substance units: false

metaR RETt
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: false
name: Retinol transport via faciliated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
type: Reaction
is: SBO:0000185

metaR ACCOAgt
reversible: true
is: SBO:0000185
name: acetyl-coa transport
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
reactant: MODEL1310110036#

metaM 2mb2coa m
constant: false
initial concentration: 1.0
is: CHEBI:57337
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
initial amount: NaN
boundary condition: false
is: HMDB02054
name: 2-methylcrotonoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
type: Species

metaR PHETHPTOX2
modifier: MODEL1310110036#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.14.16.1
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
type: Reaction
product: MODEL1310110036#
fast: false
is: SBO:0000176

metaM gthox m
has only substance units: false
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial amount: NaN
is: SBO:0000247
is: HMDB03337
is: CHEBI:58297
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_df370a2f_9726_4537_917e_6a6a63f6ab6a
boundary condition: true
has only substance units: false
is encoded by: hsa:80724
type: Species
is: SBO:0000252
initial concentration: NaN
name: ACAD10
is: G3XAJ0
initial amount: NaN
constant: false

metaM anth e
is: CHEBI:16567
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
has only substance units: false
is: HMDB01123
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: anthranilate
constant: false
initial concentration: 1.0

metaM retinol e
has only substance units: false
constant: false
type: Species
is: HMDB00305
is: CHEBI:50211
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: retinol
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3

metaR r0156
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
modifier: MODEL1310110036#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
is: SBO:0000176
reactant: MODEL1310110036#
reversible: false
type: Reaction
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_4ba24a37_3db8_469f_a18e_d1070839f973
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:7296
name: TXNRD1
type: Species

metaM prostgi2 e
initial concentration: 1.0
is: CHEBI:57403
name: prostaglandin I2(1-)
type: Species
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01335

metaR LTA4H
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.3.2.6
name: Leukotriene A-4 hydrolase
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ

metaM C02528 e
type: Species
is: HMDB00518
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: CHEBI:36234
initial amount: NaN
initial concentration: 1.0
constant: false
name: chenodeoxycholate

metaR RE3270C
is described by: ECO:0000000
name: RE3270
kinetic law: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
is: SBO:0000176
type: Reaction
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#

metaR r2525
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
reversible: true

metaM Rtotalcoa c
name: R total Coenzyme A
boundary condition: false
is: HMDB01448
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:16189
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
constant: false

metaM spc hs e
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
name: sphingosylphosphorylcholine
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5311445

http://identifiers.org/biomodels.db/MODEL1310110036#_2394da37_f6f4_4f6f_8143_8362f6b15361
constant: false
type: Species
is: SBO:0000252
name: MSMO1
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: A8MYF6
is encoded by: hsa:6307
boundary condition: true

metaR RETFAt
reactant: MODEL1310110036#
reversible: false
name: fatty acid retinol efflux
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR RE3628M
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
fast: false
name: RE3628
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_51d01208_0e4e_4761_ae16_2a9e59882e74
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:AI091231
name: _AI091231_1_c
type: Species
initial concentration: NaN
initial amount: NaN

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR CYTK1n
modifier: MODEL1310110036#
product: MODEL1310110036#
fast: false
type: Reaction
kinetic law: MODEL1310110036#
name: cytidylate kinase (CMP),nuclear
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR DNDPt36m
product: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: dGDP transport via dCDP antiport
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_8b8e3b0c_4f2f_4501_acac_c6a10f935c4f
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q9H0P0
constant: false
type: Species
is encoded by: hsa:51251
has only substance units: false
name: NT5C3

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_7b0baec8_ab86_4d98_9327_b1304172ceb7
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: O00400
is encoded by: hsa:9197
name: SLC33A1
initial concentration: NaN

metaM lcts e
has only substance units: false
is: C00243
is: HMDB00186
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
initial concentration: 1.0
is: SBO:0000247
constant: false
name: Lactose
initial amount: NaN
boundary condition: false
is: CHEBI:17716
type: Species

metaR PROSTGD2t
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110036#
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110036#
type: Reaction
fast: false
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_7e14fae4_d8d3_44a0_bb85_de4f2510401c
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6559
constant: false
is: P55017
name: SLC12A3

metaR r2526
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
reactant: MODEL1310110036#

metaM fol e
has only substance units: false
is: HMDB00121
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
type: Species
initial concentration: 1.0
name: Folate

metaR AATAi
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110036#
name: 2-aminoadipate transaminase, irreversible
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
product: MODEL1310110036#
type: Reaction

metaR D 3AIBt
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
name: D-3-amino-isobutyrate transport
type: Reaction
product: MODEL1310110036#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM dhcholestanate x
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
is: HMDB00359
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_dfa2d79f_8629_4526_8f75_5c585bc9b19d
initial amount: NaN
type: Species
name: ATIC
initial concentration: NaN
constant: false
has only substance units: false
is: P31939
is encoded by: hsa:471
boundary condition: true
is: SBO:0000252

metaM 5thf e
initial amount: NaN
is: HMDB06487
has only substance units: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: pentaglutamyl folate (THF)

metaM h2o2 e
initial amount: NaN
is: HMDB03125
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: hydrogen peroxide
constant: false

metaM gtp e
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
is: CHEBI:37565
constant: false
type: Species
is: HMDB01273
initial amount: NaN
boundary condition: false
name: GTP(4-)
initial concentration: 1.0

metaR FAS80COA L
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
reactant: MODEL1310110036#

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_12be1722_5c72_4eed_81e7_11edb381a74b
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9514
constant: false
name: GAL3ST1
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q99999
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_a59ced85_cc10_4528_9fc2_2597c1c8c1d2
type: Species
has only substance units: false
is: Q546Y9
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: AICDA
is encoded by: hsa:57379

metaM thr L c
type: Species
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00167
name: L-threonine
initial amount: NaN

metaM leuleu e
is: http://identifiers.org/pubchem.compound/94244
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C12H24N2O3 CHARGE: 0
name: Leucylleucine
is: SBO:0000247
initial amount: NaN

metaR HMGCOAtm
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaR RE3050R
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
name: RE3050
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110036#
is described by: ECO:0000000

metaR ORPT
name: orotate phosphoribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.10
is described by: ECO:0000269
kinetic law: MODEL1310110036#
fast: false
reversible: true
reactant: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:

metaR RE3347C
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
name: RE3347
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR PI4PLC
is described by: ECO:0000269
name: phosphatidylinositol 4-phosphate phospholipase C
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110036#
is: SBO:0000176
fast: false
reversible: false

metaR RE1447N
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
type: Reaction
reversible: true
name: RE1447
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR r1147
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaM dudp n
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
is: CHEBI:60471
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: dUDP(3-)

metaM C02470 c
has only substance units: false
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial concentration: 1.0
is: C02470
constant: false
initial amount: NaN
type: Species
name: Xanthurenic acid
is: HMDB00881
is: http://identifiers.org/pubchem.compound/5485
boundary condition: false
is: SBO:0000247

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR GLCAASE9ly
name: beta-glucuronidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110036#
is described by: ECO:0000269
product: MODEL1310110036#
fast: false
reversible: false
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_7488d6de_33a0_4516_a6ac_511742f877fa
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AI291895
boundary condition: true
is: SBO:0000252
name: _AI291895_1_c

metaM andrstrn r
initial concentration: 1.0
is: SBO:0000247
is: HMDB00031
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: androsterone
is: CHEBI:16032
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
has only substance units: false

metaR URATEt
is: SBO:0000185
product: MODEL1310110036#
type: Reaction
name: urate export from cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: false

metaR SADT
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.25
reversible: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000176
name: sulfate adenylyltransferase
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110036#

metaR TAGt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: triacylglycerol transport
reversible: true
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185

metaM h2o n
is: SBO:0000247
type: Species
is: CHEBI:15377
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
name: water
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB02111

metaR ACOAO7p
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
reactant: MODEL1310110036#
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
fast: false

metaR r0739
fast: false
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
is described by: ECO:0000000

metaR r1148
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110036#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Active transport
reactant: MODEL1310110036#

metaM cholcoaone x
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: CHEBI:58507
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
type: Species
is: HMDB06891
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

metaR r1671
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
modifier: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#

metaR PSSA2 hs
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.8.29
is: SBO:0000176
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
reactant: MODEL1310110036#
name: Phosphatidylserine synthase homo sapiens

metaM dudp m
name: dUDP(3-)
boundary condition: false
constant: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01000
is: CHEBI:60471

metaR H2Otg
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: H2O transport, Golgi apparatus
product: MODEL1310110036#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

metaR r0960
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_0cc5c638_67d9_42e6_ac67_8120cf758734
constant: false
name: ALDH7A1
type: Species
is encoded by: hsa:501
is: E7EPT3
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_9e3dea9d_c4c9_443e_89fb_aef8bd1a360a
boundary condition: true
has only substance units: false
is: Q96C36
is encoded by: hsa:29920
constant: false
name: PYCR2
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r0360
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
is: SBO:0000176
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.2.1.16

metaR LEULEULAPc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaM C02528 r
initial concentration: 1.0
is: HMDB00518
has only substance units: false
boundary condition: false
name: chenodeoxycholate
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: CHEBI:36234

http://identifiers.org/biomodels.db/MODEL1310110036#_9cf83bc3_e868_43b9_95c3_bf16ecd641ec
boundary condition: true
is: O14986
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8395
initial amount: NaN
type: Species
name: PIP5K1B

metaM thr L e
boundary condition: false
has only substance units: false
is: HMDB00167
type: Species
is: CHEBI:16857
initial amount: NaN
initial concentration: 1.0
constant: false
name: L-threonine
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179

http://identifiers.org/biomodels.db/MODEL1310110036#_a6db4721_fe19_4ad9_b246_07c45690d3d9
type: Species
is encoded by: hsa:4952
has only substance units: false
initial concentration: NaN
name: OCRL
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_af5bd959_408e_47a8_9a20_b0518d8a7213
is encoded by: hsa:R39999
name: _R39999_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaM HC02204 c
initial concentration: 1.0
is: CHEBI:27624
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false
name: prostaglandin-b1
initial amount: NaN
constant: false
boundary condition: false

metaR r1976
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_8b6421ee_c5b1_4f7d_9c62_31d7dfc91de8
has part: O00459
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000297
type: Species
initial concentration: NaN
is encoded by: hsa:5290
name: PIK3CA:PIK3R2
has part: P42336
has only substance units: false
is encoded by: hsa:5296

metaR r1670
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#
reversible: true
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaM tre e
has only substance units: false
is: HMDB00975
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Trehalose
type: Species
constant: false
is: C01083
initial amount: NaN
is: CHEBI:16551

http://identifiers.org/biomodels.db/MODEL1310110036#_11a8c0c9_3b9b_49bd_aba1_b9145608678a
has only substance units: false
is encoded by: hsa:4645
constant: false
type: Species
boundary condition: true
is: Q9H6Y6
initial concentration: NaN
is: SBO:0000252
name: MYO5B
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_825a3adb_c4d5_44a8_b38a_ea8111913fcf
constant: false
initial concentration: NaN
name: SDHC
is: Q99643
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:6391
boundary condition: true

metaR PRISTCOAtcx
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_9041b1fe_c353_4132_9067_cdfd900459f2
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:27034
is: Q6ZWP6
type: Species
name: ACAD8
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR FAOXC12C10m
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaM hom L e
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15699
name: L-homoserine
type: Species
boundary condition: false
is: HMDB00719
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_e40c9d29_456c_40f6_b40d_7ff8b4300f15
is encoded by: hsa:230
is: SBO:0000252
initial concentration: NaN
name: ALDOC
initial amount: NaN
type: Species
boundary condition: true
is: P09972
has only substance units: false
constant: false

metaR RE3326M
fast: false
name: RE3326
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.4.4
reversible: true
is: SBO:0000176

metaR BILIRUBtr
product: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
type: Reaction
name: lipid, flip-flop intracellular transport
fast: false
kinetic law: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_23dd07a8_20b9_4d5a_833f_691dbddbd8bb
name: _AA502753_1_m
type: Species
is: SBO:0000252
is encoded by: hsa:AA502753
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_bac8e373_446a_4505_a8fd_aa1c48456ee6
has only substance units: false
type: Species
is encoded by: hsa:4717
is: O43677
initial amount: NaN
constant: false
name: NDUFC1
is: SBO:0000252
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_bb161b9c_a182_4360_9350_3a6e133bd2f1
type: Species
is: P52824
initial concentration: NaN
is encoded by: hsa:1609
initial amount: NaN
name: DGKQ
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaR FADH2tx
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
reversible: true
name: FADH2 transporter, peroxisomal
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ

http://identifiers.org/biomodels.db/MODEL1310110036#_3422039e_0254_4f72_96c3_08fd2b314c39
type: Species
initial amount: NaN
name: ABAT
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:18
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_10cbe85d_6b8f_4be0_91d7_df29b6ba20d4
constant: false
is: SBO:0000252
boundary condition: true
name: SLC27A2
is encoded by: hsa:11001
type: Species
is: O14975
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r1975
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_3899ea7a_5be5_49e9_a4b1_7601f42796a7
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: MPST
initial concentration: NaN
is: P25325
is encoded by: hsa:4357

metaR Htx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110036#
name: H transporter, peroxisome
reversible: true
product: MODEL1310110036#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR BPNT
name: 3',5'-bisphosphate nucleotidase
modifier: MODEL1310110036#
fast: false
reversible: false
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.3.7
type: Reaction
is described by: ECO:0000269

metaM ser D e
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16523
constant: false
name: D-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial amount: NaN
is: HMDB03406

metaM mev R c
is: SBO:0000247
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
has only substance units: false
name: (R)-mevalonate
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:36464
is: HMDB00227

metaR r1600
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110036#
reversible: true

metaM ficytC m
constant: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
boundary condition: false
has only substance units: false
name: Ferricytochrome c
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:15991
initial amount: NaN

metaR H2Otm
name: H2O transport, mitochondrial
fast: false
modifier: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaM HC02204 e
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: prostaglandin-b1
has only substance units: false
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: CHEBI:27624

metaR DHCR242r
name: 24-dehydrocholesterol reductase [Precursor]
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000134
modifier: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
reactant: MODEL1310110036#
is: SBO:0000176

metaM na1 e
initial concentration: 1.0
name: Sodium
is: HMDB00588
has only substance units: false
initial amount: NaN
is: C01330
is: SBO:0000247
is: CHEBI:4541
boundary condition: false
type: Species
notes: FORMULA: Na CHARGE: 1
constant: false

metaM gthox e
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: HMDB03337
is: CHEBI:58297

metaR CHSTEROLt2
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
product: MODEL1310110036#
name: cholesterol intracellular transport
kinetic law: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR DOPAt4 2 r
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
is described by: ECO:0000269
kinetic law: MODEL1310110036#
name: Dopamine reversible transport in via sodium symport (1:2)

metaM 3mox4hoxm c
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 3-Methoxy-4-hydroxymandelate
constant: false
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
is: HMDB00291
is: CHEBI:27622
type: Species
initial concentration: 1.0

metaM udpg r
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: HMDB00286
boundary condition: false
constant: false
is: CHEBI:58367
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species

metaR ACGAMtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
kinetic law: MODEL1310110036#
reversible: false
fast: false
product: MODEL1310110036#
is: SBO:0000185
type: Reaction
name: N-acetyl-glucosamine lysosomal efflux
is described by: ECO:0000000
reactant: MODEL1310110036#

metaM tcynt e
initial concentration: 1.0
constant: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: CHEBI:18022
boundary condition: false
has only substance units: false
is: HMDB01453
type: Species
initial amount: NaN
name: thiocyanate
is: SBO:0000247

metaR RE3421R
fast: false
is: SBO:0000176
type: Reaction
name: RE3421
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_3bcf2e6a_2668_4d6c_af6c_64ee52409df7
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:55350
is: SBO:0000252
name: VNN3
initial concentration: NaN
has only substance units: false

metaM pristcoa x
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:51341

metaR r1973
modifier: MODEL1310110036#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#

metaR r0735
reversible: true
is described by: ECO:0000000
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_f8d14d58_a366_400c_a771_397fd7ac95b1
name: ETNK1
type: Species
is: Q9HBU6
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55500
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_3f3e207b_4ece_4015_b423_c94634e43cd2
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:54995
constant: false
is: SBO:0000252
name: OXSM
is: Q9NWU1

metaR GNMT
modifier: MODEL1310110036#
name: glycine N-methyltransferase
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.20

http://identifiers.org/biomodels.db/MODEL1310110036#_4f5cd2f1_95c8_4c6b_8d88_f175f90b117a
boundary condition: true
is encoded by: hsa:60490
name: PPCDC
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is: Q96CD2
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_205a31c7_b0f0_4f2b_8ed7_fadb2acd7d61
has only substance units: false
boundary condition: true
is encoded by: hsa:3707
constant: false
initial concentration: NaN
name: ITPKB
type: Species
initial amount: NaN
is: SBO:0000252
is: P27987

http://identifiers.org/biomodels.db/MODEL1310110036#_6f40f42a_5fd8_4a3f_a251_0369e21bb137
boundary condition: true
name: COL4A3BP
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:10087
type: Species
has only substance units: false
is: Q9Y5P4
initial amount: NaN

metaM 3mox4hpac m
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB05175
initial concentration: 1.0
is: CHEBI:28111
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
has only substance units: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
initial amount: NaN
type: Species

metaR CHSTEROLt3
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
product: MODEL1310110036#
name: cholesterol intracellular transport
kinetic law: MODEL1310110036#
is: SBO:0000185

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM ser D c
initial amount: NaN
is: HMDB03406
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:16523
name: D-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_c2ae50e9_8ae2_4e64_bca2_3277e7f24ca7
is: SBO:0000252
has only substance units: false
is: Q8TF71
boundary condition: true
name: SLC16A10
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:117247

http://identifiers.org/biomodels.db/MODEL1310110036#_1b1e3a20_3a1e_4bbc_81a2_a04064ebcd17
initial concentration: NaN
type: Species
name: SLCO4A1
boundary condition: true
is encoded by: hsa:28231
is: Q96BD0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaM gtp c
constant: false
is: HMDB01273
type: Species
is: CHEBI:37565
has only substance units: false
initial concentration: 1.0
name: GTP
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
boundary condition: false
is: C00044
initial amount: NaN

metaM h2o2 c
constant: false
initial amount: NaN
boundary condition: false
is: C00027
is: SBO:0000247
is: CHEBI:16240
name: Hydrogen peroxide
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
initial concentration: 1.0
is: HMDB03125

metaR ALR2
is version of: http://identifiers.org/ec-code/1.1.1.2
name: aldose reductase (methylglyoxal)
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is: SBO:0000176
reversible: false
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_061d24cd_1ed9_4ac1_8db2_32422a44a1cb
is: Q9H310
has only substance units: false
name: RHBG
initial amount: NaN
is encoded by: hsa:57127
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

metaM cdpea c
is: CHEBI:57876
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
is: SBO:0000247
boundary condition: false
is: HMDB01564
name: cdpea[c]
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN

metaM na1 c
name: Sodium
constant: false
is: HMDB00588
has only substance units: false
is: C01330
boundary condition: false
initial amount: NaN
is: CHEBI:4541
notes: FORMULA: Na CHARGE: 1
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR r1602
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR ALASm
is version of: http://identifiers.org/ec-code/2.3.1.37
type: Reaction
modifier: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000254
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.29
reactant: MODEL1310110036#
name: 5-aminolevulinate synthase

metaM h2o m
name: H2O
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
initial amount: NaN
is: HMDB02111
type: Species
has only substance units: false
is: C00001
constant: false
is: CHEBI:15377
boundary condition: false

metaR r0734
kinetic law: MODEL1310110036#
is: SBO:0000176
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
type: Reaction
product: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#

metaR RE0915E
is: SBO:0000176
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
name: RE0915
reactant: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR GSNt
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
name: guanosine facilated transport in cytosol
reactant: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
modifier: MODEL1310110036#
type: Reaction
fast: false
product: MODEL1310110036#

metaM pail34p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
has only substance units: false
is: CHEBI:57658
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM gthox c
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: C00127
is: CHEBI:58297
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
name: Oxidized glutathione
is: HMDB03337

metaM tcynt c
type: Species
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
name: thiocyanate
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:18022
initial concentration: 1.0
initial amount: NaN

metaR r1467
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
name: Postulated transport reaction
reactant: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false
product: MODEL1310110036#

metaM 10fthf6glu e
type: Species
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](6)
constant: false
initial amount: NaN
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: HMDB00972
boundary condition: false
is: SBO:0000247
is: CHEBI:57454
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_acc4a8f3_7860_4da1_8e36_b8efeb5fcb4b
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: LCT
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3938
is: P09848
has only substance units: false

metaM bilirub r
is: SBO:0000247
name: bilirubin(2-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00054
is: CHEBI:57977
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
constant: false

metaM gln L m
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: L-glutamine
is: HMDB00641
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
type: Species
is: CHEBI:18050
initial amount: NaN
constant: false

metaR BILDGLCURt
product: MODEL1310110036#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110036#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
reactant: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ

metaR r1603
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_87dc2c93_ac74_448f_a41a_8fad0073f47e
initial amount: NaN
boundary condition: true
is: P20674
name: COX5A
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:9377

metaR CYSGLYexR
reversible: true
reactant: MODEL1310110036#
is: SBO:0000185
name: L-cysteine/glycine reversible exchanger
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_6474fc76_0f48_4cb6_8574_a10790adafbf
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is: Q9NVE7
initial amount: NaN
name: PANK4
is encoded by: hsa:55229
constant: false

metaR r0733
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110036#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
modifier: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
product: MODEL1310110036#
fast: false

metaM h2o l
boundary condition: false
is: CHEBI:15377
initial amount: NaN
type: Species
initial concentration: 1.0
name: water
has only substance units: false
constant: false
is: HMDB02111
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR MAN6PI
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/5.3.1.8
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is: SBO:0000176
name: mannose-6-phosphate isomerase
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_a25f9a25_6be6_4a41_bcf7_5c7da209891c
has only substance units: false
is: F5H123
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9856
name: DYLX2
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

metaR GLUDxm
modifier: MODEL1310110036#
is described by: ECO:0000269
reversible: true
name: glutamate dehydrogenase (NAD) (mitochondrial)
reactant: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110036#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_d4d9bd21_96f1_49d8_8380_ba283e9801f8
is encoded by: hsa:347734
boundary condition: true
type: Species
is: Q8TB61
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: SLC35B2
has only substance units: false

metaR DHCHOLESTANATEtm
product: MODEL1310110036#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
name: lipid, flip-flop intracellular transport
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaR DIDPtn
is: SBO:0000185
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
name: dIDP nuclear transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR NDPK10
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is described by: ECO:0000134
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dIDP)
modifier: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176
type: Reaction

metaR r0627
is: SBO:0000176
reactant: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23

metaR ARACHCPT1
name: carnitine transferase
fast: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_ad5a635c_3dd8_4be2_999d_d9be49fbf722
is: SBO:0000252
is encoded by: hsa:8801
is: Q96I99
boundary condition: true
name: SUCLG2
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM h2o g
is: CHEBI:15377
name: water
is: HMDB02111
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

metaR CO2ter
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000185
reactant: MODEL1310110036#
name: CO2 endoplasmic reticular transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true

metaM o2 c
boundary condition: false
is: C00007
initial concentration: 1.0
is: CHEBI:15379
initial amount: NaN
name: O2
type: Species
has only substance units: false
constant: false
is: HMDB01377
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR r0591
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9

http://identifiers.org/biomodels.db/MODEL1310110036#_c34b8c87_00d9_4a5a_8ba3_f390331641c0
constant: false
is: C9JZ62
has only substance units: false
type: Species
is: SBO:0000252
name: TMEM91
is encoded by: hsa:641649
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR ARACHCPT2
modifier: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
product: MODEL1310110036#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM din c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00071
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
type: Species
name: Deoxyinosine
constant: false
is: C05512
is: CHEBI:28997

http://identifiers.org/biomodels.db/MODEL1310110036#_0f92a2de_8d7e_407d_91f5_3790b21c620a
name: VNN3:VNN2:VNN1
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000297
is encoded by: hsa:55350

metaR r0009
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reversible: false
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
kinetic law: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.1
type: Reaction
fast: false

metaM 6pgc r
is: SBO:0000247
name: 6-phosphonatooxy-D-gluconate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
has only substance units: false
is: CHEBI:58759
type: Species
is: HMDB01316
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_038d935e_d6fd_45cf_9987_ca0acded1ac8
constant: false
has only substance units: false
boundary condition: true
is: Q12882
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:1806
name: DPYD
initial amount: NaN

metaM h2o2 m
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: CHEBI:16240
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Hydrogen peroxide
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB03125
constant: false

metaM acald e
boundary condition: false
initial amount: NaN
is: CHEBI:15343
has only substance units: false
name: acetaldehyde
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM HC01410 m
name: (2E)-Hexenoyl-CoA
is: CHEBI:28706
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM h2o e
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
type: Species
name: H2O
is: HMDB02111
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:15377
boundary condition: false

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_3676ef06_6748_411b_b4e3_93814b124832
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: ALDH1A2
has only substance units: false
is: O94788
initial amount: NaN
is encoded by: hsa:8854
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_64fd4e03_9360_45d4_b40b_851e74010523
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8867
is: O43426
name: SYNJ1

metaR H2Otp
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000000
name: H2O transport, peroxisomal
is: SBO:0000185
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#

metaR r0086
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.3
fast: false
reversible: false

metaR PI345P5P
reactant: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
product: MODEL1310110036#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.36

metaR CITL
kinetic law: MODEL1310110036#
name: Citrate lyase
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
fast: false
modifier: MODEL1310110036#
is described by: ECO:0000000

metaM dhcholestanate m
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
type: Species
is: CHEBI:16577
initial concentration: 1.0
has only substance units: false
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_6acf9ea2_8ecb_412e_a81d_e57b3fa2bfac
is: Q9BXS1
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: IDI2
is: SBO:0000252
is encoded by: hsa:91734
type: Species
constant: false

metaR KHK
kinetic law: MODEL1310110036#
type: Reaction
reversible: false
reactant: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.3
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
name: ketohexokinase
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_0ef753c7_f40c_4924_84c7_836849c91d10
initial concentration: NaN
is: P07686
constant: false
is: SBO:0000252
initial amount: NaN
name: HEXB
is encoded by: hsa:3074
has only substance units: false
boundary condition: true
type: Species

metaR r0512
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_41a683de_b658_4be2_a736_c35792cc152f
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3992
name: FADS1
initial concentration: NaN
is: O60427
is: SBO:0000252
constant: false
type: Species

metaR SERDGLNexR
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000304
name: D-Serine/Glutamine reversible exchange
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_9cd7b02f_a0e1_4adf_b711_82e6c8cf8373
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: O14975
is encoded by: hsa:11001
initial concentration: NaN
is: SBO:0000252
name: SLC27A2

http://identifiers.org/biomodels.db/MODEL1310110036#_826037f2_61ce_49fd_8c6b_dc1d7507d0b2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:6241
is: P31350
boundary condition: true
constant: false
has only substance units: false
name: RRM2

metaR PAIL45P HStn
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)

metaR FKYNH
type: Reaction
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: 3.5.1.9 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: N-Formyl-L-kynurenine amidohydrolase
kinetic law: MODEL1310110036#

metaR TMDS
fast: false
name: thymidylate synthase
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
is version of: http://identifiers.org/ec-code/2.1.1.45
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000269
kinetic law: MODEL1310110036#

metaR FMNAT
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
product: MODEL1310110036#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.2
name: FMN adenylyltransferase
is described by: ECO:0000134
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#

metaR FBA2
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD

metaR CITtam
reversible: true
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000269
name: citrate transport, mitochondrial
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_91107758_09bf_403f_8880_fb32e2c885b2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ALDOA
boundary condition: true
is encoded by: hsa:226
type: Species
constant: false

metaM din e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00071
type: Species
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
has only substance units: false
constant: false
is: C05512
is: CHEBI:28997
name: Deoxyinosine

metaM lald L c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
has only substance units: false
is: CHEBI:18041
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB03052
boundary condition: false
constant: false
initial concentration: 1.0
name: (S)-lactaldehyde

metaR OCCOAtx
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110036#
name: fatty acid intracellular transport
is: SBO:0000185
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_25ce5183_f377_4de1_b987_353173e28f53
name: DGKZ
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is: B7Z2M9
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8525

http://identifiers.org/biomodels.db/MODEL1310110036#_f7522476_78f5_4e65_bcf2_569fc450320b
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: GGT2
has only substance units: false
is encoded by: hsa:728441
type: Species

metaR PSDm hs
is: SBO:0000176
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.1.1.65
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
fast: false
name: Phosphatidylserine decarboxylase
is described by: ECO:0000269

metaR GLYK
is described by: ECO:0000269
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.30
name: glycerol kinase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110036#_159c9971_d857_4b14_8440_ef3b73557e4a
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:8574
is: O43488
name: AKR7A2

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM dcyt n
type: Species
is: SBO:0000247
is: CHEBI:15698
boundary condition: false
name: 2'-deoxycytidine
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00014
initial amount: NaN
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaR H2Otn
reactant: MODEL1310110036#
name: H2O transport, nuclear
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110036#

metaM acald c
name: acetaldehyde
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
is: HMDB00990
constant: false
boundary condition: false
has only substance units: false

metaR r0594
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is described by: ECO:0000000

metaM ttdca c
initial concentration: 1.0
is: HMDB00806
name: myristate
has only substance units: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
constant: false
type: Species
is: CHEBI:30807
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR RE2079R
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
name: RE2079
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000176

metaR r0853
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
name: Facilitated diffusion
reversible: false
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR FACOAL140i
product: MODEL1310110036#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110036#
name: fatty-acid--CoA ligase (tetradecanoate)
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
reactant: MODEL1310110036#
fast: false

metaR GLYt7 211 r
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000269
name: glycine reversible transport via sodium and chloride symport (2:1:1)
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
type: Reaction
is: SBO:0000185

metaM 5adtststerones c
is: SBO:0000247
initial concentration: 1.0
is: HMDB06278
type: Species
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial amount: NaN
has only substance units: false
name: 5alpha-Dihydrotestosterone sulfate
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_53cb3a49_4d8b_4112_b0c7_1a9d19b783d6
boundary condition: true
is encoded by: hsa:1719
is: SBO:0000252
is: P00374
type: Species
initial concentration: NaN
name: DHFR
initial amount: NaN
constant: false
has only substance units: false

metaM cholp c
is: CHEBI:295975
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
name: choline phosphate(1-)
constant: false
is: SBO:0000247
has only substance units: false

metaM HC02214 c
initial concentration: 1.0
is: CHEBI:28852
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
name: prostaglandin-f1alpha
is: SBO:0000247
type: Species

metaM glc D c
is: HMDB00122
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
is: SBO:0000247
is: CHEBI:4167
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: D-glucose

metaM dhcholoylcoa x
is: SBO:0000247
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: CHEBI:27393
initial concentration: 1.0
is: HMDB06895
initial amount: NaN
type: Species
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a3ffae55_8566_46bf_a3d7_966fb0036fa0
initial concentration: NaN
initial amount: NaN
name: FASN
has only substance units: false
is: SBO:0000252
constant: false
is: P49327
is encoded by: hsa:2194
type: Species
boundary condition: true

metaR r1753
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
reversible: false
type: Reaction
kinetic law: MODEL1310110036#
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110036#
fast: false

metaR FAS100COA
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
is: SBO:0000176
name: fatty acyl-CoA synthase (n-C10:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

metaR r0083
type: Reaction
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#

metaM grdp x
constant: false
is: HMDB01285
is: CHEBI:58057
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
name: geranyl diphosphate(3-)
initial amount: NaN
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341

metaR ACACtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
name: acetoacetate intracellular transport unknown mechanism
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#

metaM CE5788 e
name: kinetensin 1-7
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
boundary condition: false
is: HMDB02710
is: CHEBI:27485
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_b2cff17b_7db6_441f_b595_60665749321b
boundary condition: true
is encoded by: hsa:R51273
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: _R51273_1_c
constant: false

metaR VITD3t2
is described by: ECO:0000000
name: Vitamin D3 uptake
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
type: Reaction

metaM HC01602 c
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
has only substance units: false
type: Species
boundary condition: false

metaR GLYt7 311 r
fast: false
is: SBO:0000185
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000006
name: glycine reversible transport via sodium and chloride symport (3:1:1)
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR LEUt5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
name: leucine mitochondrial transport
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_bda2054c_a5a5_45e9_95c8_1dc193221917
is encoded by: hsa:LOC374569
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
name: _LOC374569_1_e
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_993b60a6_39e6_4568_a43e_7d9f6d56294b
name: ALDH9A1
is encoded by: hsa:223
is: SBO:0000252
initial amount: NaN
is: P49189
has only substance units: false
initial concentration: NaN
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_2871753b_b145_4831_9b9c_46127c28c161
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:29925
constant: false
name: GMPPB
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM HC02180 c
has only substance units: false
is: SBO:0000247
is: CHEBI:28728
constant: false
initial concentration: 1.0
name: thromboxane-b2
type: Species
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false

metaR HACD1m
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is: SBO:0000176
reversible: true
fast: false
type: Reaction
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM hom L c
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:15699
has only substance units: false
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
name: L-homoserine
is: HMDB00719
initial amount: NaN

metaR r0082
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/2.6.1.2
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
product: MODEL1310110036#

metaR XOL7AONEtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110036#
is: SBO:0000185

metaR THRGLYexR
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000304
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: L-threonine/glycine reversible exchange
fast: false

metaR CAATPS
modifier: MODEL1310110036#
name: Ca ATPase
is version of: http://identifiers.org/ec-code/3.6.3.8
product: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ

metaR ADSL1
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: adenylosuccinate lyase
reversible: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
fast: false
reactant: MODEL1310110036#

metaM pa hs c
is: SBO:0000247
boundary condition: false
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_281c230e_92df_4698_9309_bab95af4a524
name: _NM_013421_1_m
boundary condition: true
initial amount: NaN
is encoded by: hsa:NM 013421
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_635c20aa_73d8_45a2_b6df_ca83da2a234e
has only substance units: false
boundary condition: true
is encoded by: hsa:23428
constant: false
is: Q86U05
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC7A8

metaR r0629
is: SBO:0000176
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.22
modifier: MODEL1310110036#
reversible: true
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110036#

metaR PI45PLC
is described by: ECO:0000000
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.4.11

metaM 5adtststerones e
constant: false
name: 5alpha-Dihydrotestosterone sulfate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_2f75ad85_c028_4287_9f43_8596901d0701
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM 6pgl r
initial amount: NaN
is: HMDB01127
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
boundary condition: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57955
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_586b61b0_76d0_46ae_abc1_534f9b00ff49
initial concentration: NaN
name: PRDX2
is encoded by: hsa:7001
boundary condition: true
initial amount: NaN
is: P32119
type: Species
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_1888b458_5891_459d_9db3_50c25e5e9b61
is: SBO:0000252
constant: false
is encoded by: hsa:8879
name: SGPL1
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: O95470

metaM HC00695 m
type: Species
name: S-Succinyldihydrolipoamide
initial concentration: 1.0
is: CHEBI:17432
boundary condition: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

metaM lpam m
name: lipoamide
is: CHEBI:17460
boundary condition: false
has only substance units: false
is: HMDB00962
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
type: Species

metaR OLEICFATPtc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaR AMPDA
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: false
product: MODEL1310110036#
fast: false
is: SBO:0000176
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
name: Adenosine monophosphate deaminase
is version of: http://identifiers.org/ec-code/3.5.4.6

http://identifiers.org/biomodels.db/MODEL1310110036#_f1e7386d_c967_4174_ab31_c73c897afa2c
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: DCK
initial concentration: NaN
is: SBO:0000252
is: P27707
is encoded by: hsa:1633
boundary condition: true

metaM HC01609 e
initial concentration: 1.0
is: SBO:0000247
name: UroporphyrinogenI
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:28766

http://identifiers.org/biomodels.db/MODEL1310110036#_4dfa55e5_558c_4ea3_952c_5c0f290886c8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23428
has only substance units: false
is: SBO:0000252
is: Q9UHI5
constant: false
initial amount: NaN
type: Species
name: SLC7A8

metaR CYOR u10m
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000134
reversible: false
name: ubiquinol-6 cytochrome c reductase, Complex III
type: Reaction
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/3.5.1.92
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH

metaR HISSNAT5tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_63c525a6_12b6_4a82_8754_2bb1614be719
boundary condition: true
is encoded by: hsa:3028
is: Q99714
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: HSD17B10
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_bd7394e4_4c6b_46d8_bed4_431221dc3550
type: Species
initial concentration: NaN
is encoded by: hsa:AV717590
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _AV717590_1_c
boundary condition: true

metaR 13DAMPPOX
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is described by: ECO:0000212
reactant: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.4.3.21
type: Reaction
reversible: false
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)

metaR r0002
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
name: Active transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000

metaM glc D e
name: D-glucose
type: Species
has only substance units: false
boundary condition: false
is: HMDB00122
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR RE0383C
product: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
reversible: true
kinetic law: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.2
name: RE0383
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reactant: MODEL1310110036#

metaR Htr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110036#
name: H transporter, endoplasmic reticulum
type: Reaction
fast: false
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
is: SBO:0000185

metaR r0085
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
modifier: MODEL1310110036#
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
type: Reaction
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_0ab05296_4552_4ed8_ac15_eebc71532710
initial concentration: NaN
is encoded by: hsa:BF195998
boundary condition: true
name: _BF195998_1_x
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR ADSL2
is version of: http://identifiers.org/ec-code/4.3.2.2
reversible: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176
fast: false
name: adenylosuccinate lyase
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110036#

metaR RE1447M
is: SBO:0000176
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110036#
fast: false
reversible: true
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_f14eb1be_a311_40d0_9da4_0e434995c0ce
constant: false
has only substance units: false
is: P42765
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10449
initial concentration: NaN
type: Species
name: ACAA2

metaM CE4792 m
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
boundary condition: false
name: 3-oxo-cis-8-tetradecenoyl-CoA
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57923

metaR PCm
type: Reaction
is: SBO:0000176
product: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
reversible: false
is version of: http://identifiers.org/ec-code/6.4.1.1
fast: false
kinetic law: MODEL1310110036#
name: pyruvate carboxylase
modifier: MODEL1310110036#
reactant: MODEL1310110036#

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR r0590
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
modifier: MODEL1310110036#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a0642c0f_0cc4_407b_8afd_5fb0ff7ca024
name: ACOT2
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is: P49753
type: Species
initial amount: NaN
is encoded by: hsa:10965
has only substance units: false

metaM HC02180 e
type: Species
name: thromboxane-b2
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaR RETH2e
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
name: retinyl ester hydrolase (11-cis), extracellular
fast: false
product: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_7f78d866_076b_4e0d_b949_8d4487449343
type: Species
name: _100128062_1_m
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:100128062

metaR NADS2
fast: false
is: SBO:0000176
modifier: MODEL1310110036#
name: NAD synthase (glutamine-hydrolysing)
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/6.3.5.1
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_048903e0_ba70_408f_9328_d3628bfc9113
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8560
boundary condition: true
name: DEGS1
type: Species
is: SBO:0000252
is: O15121
initial amount: NaN
constant: false

metaM h2o c
name: H2O
is: C00001
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:3303
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false

metaR r0084
product: MODEL1310110036#
modifier: MODEL1310110036#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.42

metaR NDPK8n
fast: false
modifier: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_25b625b8_1d74_40e5_87e2_0c96d21ace8e
is: SBO:0000252
name: _AI348006_1_c
is encoded by: hsa:AI348006
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_d77cf3a6_64d2_47fa_9ab6_cd739e0acc51
initial concentration: NaN
name: SLC25A1
is: D9HTE9
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is encoded by: hsa:6576
is: SBO:0000252

metaM xtsn c
has only substance units: false
name: xanthosine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: HMDB00299
initial concentration: 1.0
is: CHEBI:18107
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_5b1d6c14_c49e_4039_8ebf_587d6c124e47
is encoded by: hsa:343
name: AQP8
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: O94778

http://identifiers.org/biomodels.db/MODEL1310110036#_1b5d63b4_3030_4fd6_a136_358ce992bcfd
name: ADSL
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: P30566
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:158

metaM HC02187 c
is: CHEBI:28774
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: reverse-triiodthyronine
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaR r0834
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110036#
fast: false
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.16
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

metaM prostge2 e
is: CHEBI:606564
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin E2(1-)
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01220
type: Species

metaR r2127
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_0e0a1735_22fa_4cb0_adfe_523323f76ca1
boundary condition: true
constant: false
is: SBO:0000297
initial amount: NaN
has part: Q9UPY5
name: SLC7A11:SLC3A2
is encoded by: hsa:23657
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_02c42cd6_7824_4d2f_8061_8353f01f8608
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5631
type: Species
boundary condition: true
is: P60891
initial concentration: NaN
name: PRPS1

metaR MI14P4P
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: false
type: Reaction
name: inositol-1,4-bisphosphate 4-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

metaR r0246
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is: SBO:0000176
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
reversible: false

metaM 2dr5p c
is: SBO:0000247
is: CHEBI:57651
name: 2-deoxy-D-ribose 5-phosphate(2-)
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01031
constant: false
initial amount: NaN
type: Species

metaR URIt
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
name: uridine facilated transport in cytosol
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is: SBO:0000185
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#

metaM tdchola x
is: HMDB00951
name: taurochenodeoxycholate
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:9407
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false

metaM HC01405 m
is: CHEBI:28632
is: SBO:0000247
constant: false
name: (S)-Hydroxyoctanoyl-CoA
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266

metaR r1584
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_c3f3eda8_6787_4040_8775_45be9aec103b
boundary condition: true
constant: false
initial amount: NaN
is: A8K0I1
is: SBO:0000252
is encoded by: hsa:160851
type: Species
initial concentration: NaN
has only substance units: false
name: DGKH

http://identifiers.org/biomodels.db/MODEL1310110036#_96f51b33_e918_4117_8be6_a16ad0bcfc0f
boundary condition: true
initial amount: NaN
name: ALDH3A1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P30838
constant: false
type: Species
is encoded by: hsa:218

http://identifiers.org/biomodels.db/MODEL1310110036#_6dd2ceab_dd01_4099_bbbe_e8a6d87db071
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:H17063
initial concentration: NaN
boundary condition: true
name: _H17063_1_m
constant: false
has only substance units: false

metaR SGPL12r
is version of: http://identifiers.org/ec-code/4.1.2.27
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
reversible: false
fast: false
name: Sphingosine-1-phosphate lyase

metaR r2106
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110036#
type: Reaction

metaM lnlnca l
type: Species
name: alpha-linolenate
initial amount: NaN
is: CHEBI:32387
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB01388
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427

metaR RE0958E
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
reversible: true
name: RE0958

http://identifiers.org/biomodels.db/MODEL1310110036#_e5ec0433_a6c9_4ba1_9159_e11c1249405e
type: Species
name: NDUFA4
initial amount: NaN
boundary condition: true
is: O00483
constant: false
initial concentration: NaN
is encoded by: hsa:4697
has only substance units: false
is: SBO:0000252

metaM glx c
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00119
type: Species
initial concentration: 1.0
name: glyoxylate
has only substance units: false
constant: false

metaR r0835
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_4a337472_708b_4ea8_886e_c6629c007335
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:11238
initial concentration: NaN
name: CA5B
is: Q9Y2D0

metaR r2128
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110036#

metaM 34dhoxmand c
name: 3,4-Dihydroxymandelate
has only substance units: false
is: CHEBI:27637
type: Species
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial concentration: 1.0
constant: false
is: HMDB01866
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR L LACt4r
reversible: true
name: L-lactate reversible transport via sodium symport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000

metaR BHBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
fast: false
reversible: true
is: SBO:0000185
name: (R)-3-Hydroxybutanoate transport via H+ symport
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#

metaR r1255
reactant: MODEL1310110036#
type: Reaction
fast: false
name: EC:6.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110036#_bf0f7342_2edd_491f_8364_b9021dc1040f
name: IMPA2
is: O14732
is: SBO:0000252
is encoded by: hsa:3613
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaR KAS8
kinetic law: MODEL1310110036#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
product: MODEL1310110036#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
type: Reaction
modifier: MODEL1310110036#
reactant: MODEL1310110036#

metaM fad x
type: Species
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
is: CHEBI:16238

http://identifiers.org/biomodels.db/MODEL1310110036#_796d5654_f773_49c0_9df3_3da22d941cf1
has only substance units: false
name: SLC2A13
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q96QE2
is encoded by: hsa:114134

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaM amp e
is: C00020
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
name: AMP
initial amount: NaN
is: HMDB00045
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false

metaR r1583
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2103
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
fast: false
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM bilirub c
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
initial amount: NaN
is: HMDB00054
constant: false
is: CHEBI:57977
initial concentration: 1.0
has only substance units: false
type: Species
name: bilirubin(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_7387975f_6cc8_462d_bf0d_aaf3681b6a0c
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: Q308M7
constant: false
is: SBO:0000252
is encoded by: hsa:5169
name: ENPP3

metaM uri e
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
boundary condition: false
name: Uridine
is: SBO:0000247
type: Species
is: HMDB00296
initial amount: NaN
constant: false
is: CHEBI:16704
is: C00299
initial concentration: 1.0

metaR CYSTGLUex
is described by: ECO:0000269
modifier: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
is: SBO:0000185
type: Reaction
name: L-cystine/L-glutamate exchanger
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#

metaM prostge2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
initial concentration: 1.0
name: prostaglandin E2(1-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: HMDB01220
has only substance units: false

metaR r0801
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
is: SBO:0000185
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000000

metaM dgmp c
name: dGMP
is: C00362
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:57673
initial concentration: 1.0

metaM HC02217 e
initial concentration: 1.0
name: prostaglandin-g2
initial amount: NaN
is: CHEBI:27647
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_2c56be5c_066f_4059_8599_343978711ef1
name: ACADS
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:35
constant: false
has only substance units: false
is: SBO:0000252
is: P16219
initial concentration: NaN

metaR r2129
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110036#

metaM sarcs c
is: C00213
name: Sarcosine
has only substance units: false
is: SBO:0000247
is: CHEBI:3513
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00271
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0
type: Species

metaR r0560
reversible: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:

metaR RE3000M
reversible: true
name: RE3000
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176

metaR NADPHtru
name: NADPH transporter, endoplasmic reticulum
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110036#
reversible: false
fast: false

metaM crn x
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00062
is: CHEBI:16347
type: Species
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
name: L-Carnitine

metaR r1586
type: Reaction
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ACCOAC
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR r1400
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110036#
name: Active transport
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110036#

metaR NAt
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:
product: MODEL1310110036#
name: sodium transport (uniport)
is: SBO:0000185
fast: false
modifier: MODEL1310110036#

metaR r2104
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_056a7044_a059_4997_ad3d_c9e0f45dd50c
name: BCAT1
type: Species
is: P54687
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:586
boundary condition: true
initial concentration: NaN

metaM k e
initial amount: NaN
constant: false
is: HMDB00586
initial concentration: 1.0
name: potassium
is: CHEBI:29103
has only substance units: false
is: C00238
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR ASCBOX
type: Reaction
reversible: false
product: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: ascorbic acid oxidase

http://identifiers.org/biomodels.db/MODEL1310110036#_334e0f33_b511_4435_b50d_e6c67a2968ee
is: Q03393
name: PTS
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5805

metaM hyptaur c
type: Species
name: Hypotaurine
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: HMDB00965
is: CHEBI:16668
boundary condition: false
initial concentration: 1.0

metaR ACNMLr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000176
reversible: true
reactant: MODEL1310110036#
name: N-Acetylneuraminate lyase (reversible)
type: Reaction

metaR RE0691C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
name: RE0691
kinetic law: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
fast: false

metaR DCK2n
product: MODEL1310110036#
name: Deoxycytidine kinase, nuclear (UTP)
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_71c95c2e_aa44_409e_8841_3eb00a01ce8b
constant: false
is: Q9P0J0
initial amount: NaN
boundary condition: true
is encoded by: hsa:51079
is: SBO:0000252
initial concentration: NaN
type: Species
name: NDUFA13
has only substance units: false

metaR r0245
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
kinetic law: MODEL1310110036#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
type: Reaction

metaR r1585
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM amp c
constant: false
initial concentration: 1.0
is: C00020
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00045
is: CHEBI:3322
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2
name: AMP

metaM adn c
has only substance units: false
is: HMDB00050
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00212
is: CHEBI:16335
type: Species
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_b0821634_570d_474d_9ee7_55f172728095
constant: false
type: Species
name: _AL525798_1_c
is encoded by: hsa:AL525798
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r2123
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110036#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110036#
fast: false

metaM dgmp e
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:57673
constant: false
name: dGMP(2-)
is: HMDB01044
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaM retinal cis 13 r
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: HMDB06220
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
name: 13-cis-retinal
is: CHEBI:45487
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaM HC02179 e
constant: false
initial amount: NaN
name: 20-hydroxy-arachidonate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
boundary condition: false
is: CHEBI:34306
has only substance units: false
type: Species

metaM bilirub e
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
is: SBO:0000247
has only substance units: false
name: bilirubin(2-)
constant: false
is: CHEBI:57977
is: HMDB00054
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_dd8c3273_4c42_40f2_bdcc_9782ccac0892
is: SBO:0000252
constant: false
boundary condition: true
is: Q01968
is encoded by: hsa:4952
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: OCRL
type: Species

metaR r2101
type: Reaction
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110036#
fast: false

metaR EX adprbp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose 2'-phosphate exchange
type: Reaction

metaM mi1345p c
is: CHEBI:57895
is: HMDB01059
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)

metaM uri c
is: SBO:0000247
is: HMDB00296
has only substance units: false
boundary condition: false
constant: false
type: Species
name: Uridine
initial concentration: 1.0
initial amount: NaN
is: C00299
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704

metaR GNDer
fast: false
name: phosphogluconate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
reactant: MODEL1310110036#
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#

metaR ME2m
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
reversible: false
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.40
fast: false
name: malic enzyme (NADP), mitochondrial
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.38

metaR DNDPt24m
kinetic law: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
product: MODEL1310110036#
name: dTDP transport via dADP antiport
modifier: MODEL1310110036#
is described by: ECO:0000269
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction

metaM rbt e
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:15963
is: HMDB00508
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_e40dd1e6_ebda_4cc5_9e62_ef926d4415cb
is: SBO:0000252
is encoded by: hsa:5167
boundary condition: true
is: P22413
initial amount: NaN
type: Species
name: ENPP1
has only substance units: false
initial concentration: NaN
constant: false

metaR r0830
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110036#
type: Reaction
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_98eef9bf_a438_40c5_a32f_919fbc45913a
is: Q5K4L6
is: SBO:0000252
name: SLC27A3
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:11000

metaR r1580
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR r2338
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
fast: false
reversible: true
product: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110036#

metaM sarcs e
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00271
name: sarcosine
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15611
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213

metaM udp g
is: CHEBI:58223
type: Species
boundary condition: false
is: HMDB00295
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaR r2124
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_6ff97ea9_b366_4463_a93f_128fc39c1e9d
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: GUK1
constant: false
is: Q16774
is encoded by: hsa:2987
has only substance units: false

metaR r2102
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR PYRt2m
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
is: SBO:0000185
name: pyruvate mitochondrial transport via proton symport
type: Reaction
product: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: true
fast: false

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaM orn m
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: C01602
has only substance units: false
is: SBO:0000247
name: Ornithine
is: HMDB00214
initial concentration: 1.0
is: CHEBI:46912
notes: FORMULA: C5H13N2O2 CHARGE: 1

metaR SUCCt2m
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000269
name: succinate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
reactant: MODEL1310110036#

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR r1259
name: EC:6.2.1.3
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
product: MODEL1310110036#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_4407e95d_a085_4387_9887_8e16998509cf
is: P36969
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:2879
initial concentration: NaN
is: SBO:0000252
name: GPX4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_d3cfbc1b_94fc_4a01_9919_e3b8a909882a
name: UPP1
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:7378
boundary condition: true
initial concentration: NaN
type: Species

metaM leuktrB4 e
has only substance units: false
name: leukotriene B4(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01085
boundary condition: false
is: CHEBI:57461

metaR NDPK5n
fast: false
type: Reaction
product: MODEL1310110036#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
is described by: ECO:0000304

metaR r2125
kinetic law: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b1f9f601_1526_4a83_8e3c_c873bfc74c62
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10999
is: Q6P1M0
name: SLC27A4
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_29fd8dbe_750a_45d5_905a_418d39790b76
is: P00326
is encoded by: hsa:126
name: ADH1C
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

metaM adn e
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: Adenosine
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
is: HMDB00050
is: C00212
has only substance units: false
boundary condition: false

metaR RPE
reactant: MODEL1310110036#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110036#
name: ribulose 5-phosphate 3-epimerase
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/5.1.3.1
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110036#

metaM pi x
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: hydrogenphosphate
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
is: HMDB00973
constant: false

metaM gln L c
name: L-glutamine
is: CHEBI:18050
has only substance units: false
is: SBO:0000247
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_bbd885a1_373d_4501_b6f7_dd4ba166b6bc
is encoded by: hsa:AA278423
name: _AA278423_1_c
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaM acmana c
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
boundary condition: false
is: CHEBI:17122
constant: false
initial concentration: 1.0
is: HMDB01129
initial amount: NaN
is: SBO:0000247
name: N-acetyl-D-mannosamine
type: Species
has only substance units: false

metaM HC02179 c
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:34306
type: Species
name: 20-hydroxy-arachidonate

metaM rbt c
boundary condition: false
is: SBO:0000247
name: D-ribitol
type: Species
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
has only substance units: false
constant: false
is: CHEBI:15963
initial concentration: 1.0

metaM trdrd m
is: SBO:0000247
name: Reduced thioredoxin
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:15967
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

metaM h x
name: proton
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
constant: false
is: C00080
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
is: CHEBI:24636
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_f4a1a663_cf19_4470_9f3d_970879354f74
constant: false
initial concentration: NaN
name: _AI601100_1_m
initial amount: NaN
is encoded by: hsa:AI601100
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

metaR r0013
reversible: false
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
modifier: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_5ca3da5b_fb69_4dd7_814c_50138236a388
type: Species
initial concentration: NaN
name: LEFTY1
is: SBO:0000252
constant: false
initial amount: NaN
is: O75610
is encoded by: hsa:10637
boundary condition: true
has only substance units: false

metaM hmgcoa c
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15467
is: HMDB01375
boundary condition: false
name: Hydroxymethylglutaryl-CoA
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
type: Species

metaM udp e
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
is: HMDB00295
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: UDP(3-)
type: Species
has only substance units: false

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR r2126
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0249
reversible: true
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
type: Reaction
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.7.12
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is described by: ECO:0000000

metaM leuktrB4 c
is: HMDB01085
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:57461
has only substance units: false
boundary condition: false
constant: false
name: leukotriene B4(1-)
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165

metaR 3MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
name: Transport of 3-methyl-2-oxopentanoate
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110036#

metaM HC01610 e
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false
name: CoproporphyrinogenI
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
is: CHEBI:28607
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_cab9a90d_718d_4f13_a30a_640f8ec8710c
name: PKLR
is encoded by: hsa:5313
initial amount: NaN
is: P30613
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false

metaR r2100
modifier: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110036#

metaM chtn e
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: chitin
is: HMDB03362
boundary condition: false
is: SBO:0000247
is: CHEBI:17029
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118

metaR FAS160COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
name: fatty-acyl-CoA synthase (n-C16:0CoA)
reversible: false
is: SBO:0000176
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_6119f603_0fdd_40bb_be9e_8c4c3e4ecf00
is: P08319
name: ADH4
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:127
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_5e64eb22_a1fb_49bb_8db5_6b601fe86d60
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:53919
boundary condition: true
is: Q5JPA4
is: SBO:0000252
constant: false
has only substance units: false
name: SLCO1C1

http://identifiers.org/biomodels.db/MODEL1310110036#_e628b4c3_fc58_4e3d_92c0_bbe518e3193d
is encoded by: hsa:6530
constant: false
type: Species
has only substance units: false
boundary condition: true
name: SLC6A2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q96KH8

http://identifiers.org/biomodels.db/MODEL1310110036#_977516fd_bc39_4315_8102_5a1974d891f4
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:121278
initial concentration: NaN
name: TPH2
is: Q8IWU9
constant: false

metaR r1581
fast: false
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR IPDDIx
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.2
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
name: isopentenyl-diphosphate D-isomerase
reactant: MODEL1310110036#
fast: false

metaR ECOAH1m
reversible: true
type: Reaction
product: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.18
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_45482870_a948_409d_9ba6_6909c04aaad6
boundary condition: true
initial amount: NaN
constant: false
name: SLC6A4
type: Species
has only substance units: false
is encoded by: hsa:6532
is: P31645
initial concentration: NaN
is: SBO:0000252

metaM crn r
is: CHEBI:16347
name: (R)-carnitine
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_e46dc285_f7e4_4d9d_ad9f_463ac5370845
is encoded by: hsa:124
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P07327
constant: false
type: Species
initial concentration: NaN
name: ADH1A

metaR DNDPt15m
reversible: false
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
name: dUDP transport via dGDP antiport
reactant: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#

metaM man6p c
name: D-Mannose 6-phosphate
is: HMDB01078
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
constant: false
initial concentration: 1.0
is: CHEBI:17369

metaM lpro m
initial concentration: 1.0
is: CHEBI:15804
has only substance units: false
name: Lipoylprotein
notes: FORMULA: S2X CHARGE: 0 EHMN_ABBREVIATION: C02051
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaR CYTK8n
is: SBO:0000176
name: cytidylate kinase (CMP,dATP),nuclear
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110036#

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR LPCOXp
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is: SBO:0000176
fast: false
name: L-pipecolate oxidase, peroxisomal
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.5.3.1
reactant: MODEL1310110036#

metaR FADH2ETC
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
is: SBO:0000176
is described by: ECO:0000134
name: Complex II reaction for respiratory chain
reversible: false

metaR MTHFDm
kinetic law: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
modifier: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000269
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is: SBO:0000176
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
type: Reaction

metaM h r
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
is: CHEBI:24636
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: C00080
constant: false
name: proton

metaR r1931
is: SBO:0000185
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM gln L e
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
has only substance units: false
is: HMDB00641
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:18050
is: SBO:0000247
name: L-glutamine
initial amount: NaN

metaM 2obut c
is: CHEBI:16763
initial concentration: 1.0
is: HMDB00005
name: 2-Oxobutanoate
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: C00109

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_a88c001f_7b72_4e31_a47e_95f4bf7797d1
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:6535
name: SLC6A8
type: Species
is: B4DIA3

metaR r0774
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110036#
reversible: true
is described by: ECO:0000000

metaR r0456
kinetic law: MODEL1310110036#
reversible: false
modifier: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.32
type: Reaction
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113

metaR RDH3a
modifier: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.300
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
product: MODEL1310110036#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
name: retinol dehydrogenase (11-cis,NADPH)
reactant: MODEL1310110036#
fast: false
type: Reaction
reversible: true

metaR XYLTt
fast: false
type: Reaction
name: Xylitol transport via passive diffusion
reactant: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_e422b4c1_14d0_4e3d_9af2_47563a3f1d8e
constant: false
is: SBO:0000252
type: Species
name: PAICS
is: P22234
initial amount: NaN
is encoded by: hsa:10606
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR FOLt2le
kinetic law: MODEL1310110036#
reversible: true
name: folate transport via anion exchange
type: Reaction
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

metaR SO4OXAtex2
name: sulfate transport via oxalate countertransport (2:1)
kinetic law: MODEL1310110036#
reversible: false
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f6ca9b6d_5602_47b5_8274_6850a84ba903
constant: false
type: Species
boundary condition: true
is: P54868
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3158
name: HMGCS2

metaR r2120
kinetic law: MODEL1310110036#
type: Reaction
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2406
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_e513162d_1d78_4c15_8b22_aa80b7d0ecb9
type: Species
constant: false
name: PANK1
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:53354
is: SBO:0000252

metaM lnlnca r
name: alpha-linolenate
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:32387
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
is: SBO:0000247
is: HMDB01388

metaR PYRt2r
is described by: ECO:0000269
kinetic law: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
is: SBO:0000185
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
name: pyruvate reversible transport via proton symport
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
type: Reaction

metaR r1365
name: Vesicular transport
type: Reaction
fast: false
reversible: false
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#

metaR SPH1Pte
reactant: MODEL1310110036#
name: sph1p transport
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
is: SBO:0000185
kinetic law: MODEL1310110036#

metaR r1609
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR MAN1PT2
modifier: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.7.13
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
name: mannose-1-phosphate guanylyltransferase (GDP)

http://identifiers.org/biomodels.db/MODEL1310110036#_c1ddcdfd_3d56_4a98_a6af_83ca70cd06fd
name: _BE042354_1_m
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:BE042354
initial amount: NaN

metaR r0809
fast: false
product: MODEL1310110036#
name: Facilitated diffusion
is: SBO:0000185
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
modifier: MODEL1310110036#

metaR GLUPRT
name: glutamine phosphoribosyldiphosphate amidotransferase
kinetic law: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.14
is described by: ECO:0000269

metaM HC02208 c
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
initial amount: NaN
is: CHEBI:27696
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0

metaM uri m
type: Species
initial amount: NaN
name: uridine
is: HMDB00296
constant: false
is: CHEBI:16704
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299

http://identifiers.org/biomodels.db/MODEL1310110036#_abebc6e6_b021_4ac8_8c16_547cf9422e1e
boundary condition: true
initial amount: NaN
name: DUOX1
is: SBO:0000252
constant: false
is encoded by: hsa:53905
type: Species
initial concentration: NaN
has only substance units: false

metaM tcynt m
has only substance units: false
is: HMDB01453
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: thiocyanate
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: CHEBI:18022
initial amount: NaN
boundary condition: false

metaM itacon m
is: HMDB02092
initial amount: NaN
is: SBO:0000247
is: CHEBI:17240
name: itaconate(2-)
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
constant: false
has only substance units: false

metaR r2121
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r0989
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
name: Postulated transport reaction
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000

metaR r2407
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_00039fc2_0841_4745_a89f_8822f19effd3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _H77542_1_c
constant: false
type: Species
boundary condition: true
is encoded by: hsa:H77542
has only substance units: false

metaM sbcoa x
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
type: Species
is: C14143
initial concentration: 1.0
constant: false
is: HMDB04047
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: suberylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_0aa39fd2_5a09_4169_a324_79b9827c4ee4
initial amount: NaN
initial concentration: NaN
name: NT5C2
boundary condition: true
has only substance units: false
is encoded by: hsa:22978
is: SBO:0000252
is: P49902
constant: false
type: Species

metaM udp r
is: SBO:0000247
is: HMDB00295
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP
initial concentration: 1.0
is: C00015
is: CHEBI:58223
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR PPAt
reversible: false
reactant: MODEL1310110036#
type: Reaction
fast: false
name: Propionate transport, diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_7f68e251_b3cd_4af5_8902_234e8d0262de
is encoded by: hsa:83594
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q9BQG2
initial amount: NaN
has only substance units: false
name: NUDT12

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_74a0ad67_f585_4481_820d_d0529a1e6dc0
is: Q02318
is encoded by: hsa:1593
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: CYP27A1
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR UGCG
product: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.80
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
name: Ceramide glucosyltransferase
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ

metaR P5CR
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
name: pyrroline-5-carboxylate reductase
fast: false
reactant: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
reversible: false
type: Reaction
kinetic law: MODEL1310110036#

metaM glx m
initial amount: NaN
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
is: HMDB00119
is: CHEBI:36655
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR C3STDH1Pr
is version of: http://identifiers.org/ec-code/1.1.1.170
is described by: ECO:0000134
fast: false
reactant: MODEL1310110036#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reversible: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_a3fed46a_2a8e_4e7a_9077_afeb72c90cfd
constant: false
is encoded by: hsa:257202
has only substance units: false
is: SBO:0000252
is: P59796
boundary condition: true
type: Species
initial amount: NaN
name: GPX6
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_d7cc4537_b3a9_49ed_a9b9_e6c4b3cbd405
is: SBO:0000252
name: TM7SF2
is: O76062
type: Species
boundary condition: true
is encoded by: hsa:7108
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaM glac r
type: Species
initial amount: NaN
is: HMDB06355
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18268
name: D-glucurono-6,3-lactone
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
has only substance units: false

metaR HSD3B7P
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.181
reactant: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
fast: false
type: Reaction
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110036#
reversible: false

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR MI1PP
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: myo-inositol 1-phosphatase
is described by: ECO:0000269
reversible: false
product: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.3.25
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a3966c87_a41e_41f6_a6a7_908c4c3429bd
boundary condition: true
initial concentration: NaN
is: P34896
name: SHMT1
type: Species
is encoded by: hsa:6470
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM orn c
is: C01602
boundary condition: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
type: Species
is: CHEBI:0
name: Ornithine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00214
has only substance units: false
constant: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR r2122
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1608
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000

metaM 2mpdhl m
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false
is: CHEBI:17577
type: Species
is: SBO:0000247
name: S-(2-Methylpropanoyl)-dihydrolipoamide
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_975bbfcb_944a_4109_ac1f_d0ad76485db0
is: P23109
is: SBO:0000252
has only substance units: false
type: Species
name: AMPD1
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:270
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f9e3d63b_bd44_4769_81e9_eb2d524eb818
name: GALE
boundary condition: true
initial amount: NaN
is encoded by: hsa:2582
is: Q38G75
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaM ach c
is: HMDB00895
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
constant: false
is: CHEBI:15355
boundary condition: false

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

metaM Rtotal2 c
is: CHEBI:57876
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01564
notes: FORMULA: CO2FULLR2 CHARGE: -1
constant: false
initial amount: NaN
name: R total 2 position
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_cbb341c4_f74d_455b_bdc1_154defa5e8e8
boundary condition: true
type: Species
has only substance units: false
is: Q9UBM7
name: DHCR7
is: SBO:0000252
is encoded by: hsa:1717
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0355
fast: false
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_c76ceeda_5026_4e5b_b2aa_5a30bdfa67b5
boundary condition: true
name: ADH1A:ADH1B
is encoded by: hsa:124
initial concentration: NaN
is: SBO:0000297
has part: P07327
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR r1607
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000000

metaR RE1796R
reactant: MODEL1310110036#
name: RE1796
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: true
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000

metaR r0838
is version of: http://identifiers.org/ec-code/3.1.2.4
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
modifier: MODEL1310110036#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
fast: false
name: Free diffusion

http://identifiers.org/biomodels.db/MODEL1310110036#_60fa1108_8207_4eda_8bb6_6f4fbaecfe71
type: Species
initial amount: NaN
initial concentration: NaN
is: Q15111
has only substance units: false
boundary condition: true
name: PLCL1
is encoded by: hsa:5334
constant: false
is: SBO:0000252

metaM sarcs m
name: Sarcosine
boundary condition: false
constant: false
is: C00213
is: CHEBI:15611
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: SBO:0000247
is: HMDB00271
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_09f0fef8_ae71_4164_bc3a_bf65209bd4d8
initial concentration: NaN
has only substance units: false
type: Species
is: P23368
is encoded by: hsa:4200
name: ME2
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaM HC02217 c
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:27647

metaM h n
initial concentration: 1.0
is: CHEBI:24636
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: proton

metaR DESAT20 1
modifier: MODEL1310110036#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1a45e0bd_e8a7_4bb5_9fcd_255b596dac83
initial concentration: NaN
is: Q6FGA0
initial amount: NaN
is encoded by: hsa:9167
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: COX7A2L
constant: false

metaR HPYRRy
is version of: http://identifiers.org/ec-code/1.1.1.79
name: Hydroxypyruvate reductase (NADPH)
is described by: ECO:0000269
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
reactant: MODEL1310110036#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_aeea9fde_fa29_4bd9_8aae_4219feda7311
is encoded by: hsa:1109
is: P17516
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: AKR1C4
initial concentration: NaN

metaR r1364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110036#
type: Reaction
reversible: false
kinetic law: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
name: Vesicular transport
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_5c4f3750_48d4_4153_85bc_fdbbc6e4ea0e
is encoded by: hsa:728226
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: _728226_1_e
boundary condition: true

metaM pail5p hs c
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_3453429e_b5db_4d27_b5cc_6fe148cac889
is: P14324
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:2224
name: FDPS
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM ala L m
initial amount: NaN
is: CHEBI:16977
has only substance units: false
type: Species
boundary condition: false
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR RETNt
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
is: SBO:0000185
fast: false
name: retinoic acid transport
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110036#_d7288415_68bd_4ff4_9330_e2f172bd24f5
is: Q9NQU1
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:65010
constant: false
boundary condition: true
is: SBO:0000252
name: SLC26A6
initial concentration: NaN

metaM sphgn c
initial concentration: 1.0
name: sphinganine(1+)
is: HMDB00269
initial amount: NaN
has only substance units: false
is: CHEBI:57817
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: SBO:0000247
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_4f962b41_b5d8_49ee_b8ab_3fa4c4de7a45
is encoded by: hsa:1892
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P30084
constant: false
initial amount: NaN
name: ECHS1
type: Species

metaM orn e
initial concentration: 1.0
name: Ornithine
is: SBO:0000247
constant: false
is: CHEBI:0
is: HMDB00214
is: C01602
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaR r1606
reactant: MODEL1310110036#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110036#
is described by: ECO:0000000

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_5d70d6d9_5200_4a49_a47e_ee3253be1fbd
is: Q99798
is encoded by: hsa:50
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: ACO2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_7cc6fcad_79c4_49b3_91fd_87b781cf170e
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9HBF5
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:400410
name: ST20
constant: false

metaM h m
has only substance units: false
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
is: C00080
boundary condition: false
constant: false
name: proton
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110036#_0b5af04b_ec3b_44a1_9451_5d61ded804fb
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: _AI684467_1_m
initial concentration: NaN
is encoded by: hsa:AI684467
has only substance units: false

metaR r0839
kinetic law: MODEL1310110036#
name: Postulated transport reaction
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
modifier: MODEL1310110036#

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM ach e
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
name: acetylcholine
is: CHEBI:15355
is: HMDB00895
initial amount: NaN
boundary condition: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR RIBt
name: ribose transport via diffusion
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
is: SBO:0000185
product: MODEL1310110036#
is described by: ECO:0000000

metaM cdpchol c
is: HMDB01413
name: CDPcholine
is: SBO:0000247
notes: FORMULA: C14H25N4O11P2 CHARGE: -1 INCHI: InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00263 EHMN_ABBREVIATION: C00307
is: CHEBI:16436
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_9596d2c7_3575_4506_ad55_80559767714f
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: Q8TCG5
name: CPT1C
is encoded by: hsa:126129
constant: false

metaR ACACT5p
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110036#
is: SBO:0000176
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
product: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM pan4p m
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial concentration: 1.0
is: HMDB01416
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
name: pantetheine 4'-phosphate(2-)
initial amount: NaN

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM udp m
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00295
is: CHEBI:58223
name: UDP(3-)
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_39f686f6_2b6a_4fe3_9716_c89c33393c1b
is encoded by: hsa:53905
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: DUOX1
is: Q9NRD9
type: Species
boundary condition: true
initial concentration: NaN

metaM Rtotal2 e
type: Species
initial concentration: 1.0
is: HMDB00244
is: C00255
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:3554
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
name: R total 2 position
initial amount: NaN

metaR RE1533M
reactant: MODEL1310110036#
name: RE1533
product: MODEL1310110036#
fast: false
is: SBO:0000176
modifier: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR DSAT
reactant: MODEL1310110036#
reversible: false
name: dihydrosphingosine N-acyltransferase
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
kinetic law: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM hLkynr c
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 3-hydroxy-L-kynurenine
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
initial concentration: 1.0
is: HMDB11631
is: CHEBI:17380
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_e03fcc8f_d8d3_4917_9b5b_1c04c5cb85c1
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:491
constant: false
name: ATP2B2
is: SBO:0000252
is: Q4J699
type: Species

metaM HC02187 e
is: CHEBI:28774
constant: false
initial amount: NaN
name: reverse-triiodthyronine
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
boundary condition: false
type: Species

metaR FAEL204
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110036#
fast: false
name: fatty-acyl-CoA elongation (n-C20:4CoA)

metaR r1605
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false

metaR r0779
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reactant: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
fast: false

metaM lnlc e
initial amount: NaN
name: linoleate
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: SBO:0000247
is: CHEBI:30245
has only substance units: false
type: Species
is: HMDB00673
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_8349065b_82d9_401a_b809_761df400bd3c
initial concentration: NaN
name: _AA419122_1_c
is: SBO:0000252
is encoded by: hsa:AA419122
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaR NDP7g
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
fast: false
name: nucleoside-diphosphatase (UDP), Golgi apparatus
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_a62be326_7237_437f_a6f8_fe8a2e6eeb3c
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: PRPS1L1
has only substance units: false
is: P21108
initial concentration: NaN
is encoded by: hsa:221823
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_718df604_b1be_4e08_8c55_765291e5aeac
is: O00154
has only substance units: false
boundary condition: true
name: ACOT7
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:11332
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_866650de_efec_417e_be8a_b44df47e8c4c
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: AMPD2
boundary condition: true
is: B2RB47
type: Species
is encoded by: hsa:271

metaM udp n
initial amount: NaN
constant: false
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
type: Species
is: SBO:0000247
is: CHEBI:58223
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM crn m
is: HMDB00062
type: Species
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
is: CHEBI:16347
initial amount: NaN
is: C00318
has only substance units: false
constant: false
name: L-Carnitine
initial concentration: 1.0

metaM clpn hs c
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15589
notes: FORMULA: CHARGE: 0
is: HMDB00156
is: SBO:0000247
name: clpn_hs[c]

metaM cdpdag hs c
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
name: CDP-diacylglycerol(2-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58332
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_8816f063_d0e8_44d5_89ef_20cf79ce5260
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9H2B4
is encoded by: hsa:10861
type: Species
name: SLC26A1
boundary condition: true

metaR ACONTm
reversible: true
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110036#
name: Aconitate hydratase
is: SBO:0000176
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_cb3339da_9dda_4a2a_b100_f0c9dda53d95
is encoded by: hsa:3156
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: P04035
initial concentration: NaN
initial amount: NaN
name: HMGCR
boundary condition: true

metaR PGDI
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.3.99.2
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
modifier: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.18
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: Prostaglandin-H2 D-isomerase [Precursor]

http://identifiers.org/biomodels.db/MODEL1310110036#_ea3aed96_578d_4bb8_be36_389d09900807
is: P61457
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: PCBD1
is: SBO:0000252
is encoded by: hsa:5092
constant: false
type: Species

metaR r0354
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction

metaR r0450
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110036#
type: Reaction
reversible: true
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000176

metaR THFtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction

metaR GLNLASEer
reversible: true
is described by: ECO:0000000
name: gluconolactonase, endoplasmic reticulum
is: SBO:0000176
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
fast: false
kinetic law: MODEL1310110036#

metaR r1604
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_dab31eaa_04dc_4dc4_984a_4244f3f87545
type: Species
name: PYCRL
is encoded by: hsa:65263
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q53H96

metaR PI45P3K
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
reversible: false
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.153
is: SBO:0000176
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
type: Reaction

metaR r1020
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110036#
name: Postulated transport reaction
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_31340895_ec0c_4167_85b6_a41697414b5b
is encoded by: hsa:1374
initial concentration: NaN
is: Q8WZ48
initial amount: NaN
name: CPT1A
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR PAIL4P HStn
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1e2f7cfe_1ba6_4ae0_b523_d20a26507009
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SLC25A19
is encoded by: hsa:60386
is: Q9HC21
type: Species

metaR r1614
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#
is: SBO:0000185
reversible: true
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_01455c42_7df9_484d_a210_4782afccf55a
initial amount: NaN
is: G5E960
name: PLCB3
constant: false
is encoded by: hsa:5331
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM glutcoa m
boundary condition: false
is: CHEBI:57378
has only substance units: false
is: SBO:0000247
type: Species
name: glutaryl-CoA(5-)
is: HMDB01339
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
constant: false

metaM ru5p D c
is: SBO:0000247
is: CHEBI:58121
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial concentration: 1.0
is: HMDB00618
name: D-ribulose 5-phosphate(2-)

metaR NTD2m
is described by: ECO:0000269
modifier: MODEL1310110036#
name: 5'-nucleotidase (UMP), mitochondrial
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
fast: false
is: SBO:0000176

metaM ins c
type: Species
boundary condition: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
name: Inosine
is: C00294
constant: false
is: CHEBI:17596
initial amount: NaN
is: SBO:0000247
is: HMDB00195
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_43b80def_c7d2_4b55_8123_d9d674cdaf07
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:222
is: P48448
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: ALDH3B2

http://identifiers.org/biomodels.db/MODEL1310110036#_8670214c_b221_46e3_acf2_e1eea871f413
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55293
name: UEVLD
is: Q8IX04
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaM pyr c
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1
constant: false
initial concentration: 1.0
is: CHEBI:15361
is: HMDB00243
initial amount: NaN
is: C00022
type: Species
name: pyruvate

metaR G3PD1
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
reversible: true
type: Reaction
is described by: ECO:0000269
product: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.8
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
name: glycerol-3-phosphate dehydrogenase (NAD)

http://identifiers.org/biomodels.db/MODEL1310110036#_728d51cc_f752_49ee_8402_066805637fd6
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: Q8TD30
name: GPT2
initial concentration: NaN
type: Species
is encoded by: hsa:84706

metaR RE1796M
product: MODEL1310110036#
name: RE1796
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
reversible: true
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000000

metaM xol7aone m
is: SBO:0000247
initial concentration: 1.0
is: HMDB01993
initial amount: NaN
type: Species
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
constant: false
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

http://identifiers.org/biomodels.db/MODEL1310110036#_eac6208c_c3af_4be5_8b78_0225223616b3
is encoded by: hsa:23396
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: O60331
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PIP5K1C

http://identifiers.org/biomodels.db/MODEL1310110036#_ab9f8832_52ad_4e10_9f9b_c4f74fd3472e
boundary condition: true
constant: false
name: ACADM
is: SBO:0000252
is: P11310
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:34

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaR NH4t3r
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000185
name: ammonia transport via proton antiport
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
is described by: ECO:0000269

metaM 1p3h5c m
is: SBO:0000247
is: CHEBI:6151
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
initial concentration: 1.0
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
boundary condition: false
has only substance units: false
constant: false
is: HMDB01369
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_ae6d2c4b_2522_4c5f_ada1_76e11f6b8236
is encoded by: hsa:9057
is: Q92536
is: SBO:0000252
name: SLC7A6
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_735d959e_7427_44d1_81e3_adf91a309af1
constant: false
has only substance units: false
is encoded by: hsa:51
initial concentration: NaN
is: B4DK61
is: SBO:0000252
initial amount: NaN
type: Species
name: ACOX1
boundary condition: true

metaM HC01842 c
is: CHEBI:31997
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
name: Phosphodimethylethanolamine
type: Species
initial amount: NaN
constant: false
boundary condition: false

metaR r1615
is: SBO:0000185
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_711978e4_5db9_4b8f_bf17_4c3fdacc075e
initial concentration: NaN
has only substance units: false
is: P19961
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:280
name: AMY2B
initial amount: NaN

metaM thcholoylcoa x
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
type: Species
is: HMDB12456
is: CHEBI:27403
initial concentration: 1.0
boundary condition: false
constant: false
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110036#_b080274c_5c7a_49db_b0db_a050c4a7c35d
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:57379
name: AICDA
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: Q546Y9

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR PPCDC
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
modifier: MODEL1310110036#
name: phosphopantothenoylcysteine decarboxylase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_90c18914_8dff_4f13_b0b2_3e85c9cfd9bf
constant: false
name: _AI090874_1_c
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI090874
is: SBO:0000252
has only substance units: false
type: Species

metaM 5fthf m
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57457
has only substance units: false
initial amount: NaN
name: 5-formyltetrahydrofolate(2-)
is: HMDB01562
boundary condition: false

metaR r0129
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:

metaR PI5P3K
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.154
name: phosphatidylinositol-5-phosphate 3-kinase
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110036#

metaR DM ethamp r
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM ins e
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
constant: false
is: CHEBI:17596
initial amount: NaN
is: C00294
is: SBO:0000247
name: Inosine
is: HMDB00195
initial concentration: 1.0

metaR TALA
is version of: http://identifiers.org/ec-code/2.2.1.2
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
name: transaldolase
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_617c600e_2f59_4d97_a2d5_e6cdd7f4c490
name: SLC5A12
is encoded by: hsa:159963
is: Q1EHB4
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r1612
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110036#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110036#

metaR r0994
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
is: SBO:0000185
name: Facilitated diffusion
reversible: true
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_d7a75582_3977_48a8_8a8b_193bcf1ab498
constant: false
boundary condition: true
name: GALK2
has only substance units: false
initial concentration: NaN
is: Q01415
is encoded by: hsa:2585
type: Species
is: SBO:0000252
initial amount: NaN

metaM pyr e
is: SBO:0000247
boundary condition: false
constant: false
name: pyruvate
has only substance units: false
is: CHEBI:15361
is: HMDB00243
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species

metaR H2Otly
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
name: H2O transport, lysosomal

metaR MAL Lte
is described by: ECO:0000134
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
name: Transport of L-malate
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110036#
fast: false

metaM h l
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: proton
is: SBO:0000247
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
initial concentration: 1.0
is: C00080

metaR ADKd
reversible: true
product: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000269
name: adenylate kinase (d form)
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)

metaR r1613
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0993
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: false
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_06570e5b_ca86_4e8f_90f2_914743e08ac1
has only substance units: false
is: SBO:0000252
is: Q99884
is encoded by: hsa:6534
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: SLC6A7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_615a991f_a0ee_4424_88c6_f68a37461999
constant: false
is: Q8N9L9
boundary condition: true
has only substance units: false
is encoded by: hsa:122970
initial amount: NaN
type: Species
name: ACOT4
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_f8b0efba_5d8d_488b_a810_1b1a158f4fad
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: _AU149534_1_e
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AU149534

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaM duri e
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
is: CHEBI:16450
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: Deoxyuridine
is: C00526
initial amount: NaN
is: HMDB00012
constant: false

metaR DHCR243r
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110036#
name: 24-dehydrocholesterol reductase [Precursor]
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
reactant: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000134

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM h e
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
name: proton
has only substance units: false
is: C00080
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:24636

http://identifiers.org/biomodels.db/MODEL1310110036#_ce71ed0a_6441_4807_a446_da6aa8ff79c1
type: Species
is: SBO:0000297
has only substance units: false
initial amount: NaN
is encoded by: hsa:4830
constant: false
boundary condition: true
initial concentration: NaN
name: NME1:NME2

http://identifiers.org/biomodels.db/MODEL1310110036#_2ef0fcaf_05d1_4a69_90f9_db04bb22ab16
is: Q92959
name: SLCO2A1
initial concentration: NaN
is encoded by: hsa:6578
type: Species
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaM ptrc c
initial concentration: 1.0
constant: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: SBO:0000247
is: HMDB01414
type: Species
initial amount: NaN
name: Putrescine
is: C00134
has only substance units: false
is: CHEBI:326268
boundary condition: false

metaR DAGK hs
kinetic law: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
reversible: true
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.107

metaR EX 34hpp
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM hco3 m
has only substance units: false
constant: false
initial concentration: 1.0
is: C00288
name: Bicarbonate
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:17544
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595

metaM pi e
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: C00009
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
is: HMDB00973
is: SBO:0000247
is: CHEBI:43474

http://identifiers.org/biomodels.db/MODEL1310110036#_a9e620c8_0741_4489_ab74_aea998f58660
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2875
name: GPT
is: P24298
boundary condition: true
type: Species

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR RE0577C
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0577
product: MODEL1310110036#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110036#
reversible: true

metaR r1610
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_c7025519_8eab_4f1a_8ba0_082cf22907ca
initial amount: NaN
name: GPX7
is: SBO:0000252
is: Q96SL4
constant: false
is encoded by: hsa:2882
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR LEUKTRB4t
fast: false
is: SBO:0000185
name: leukotriene B4 transport
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_5b8f664d_8caa_43c5_9656_942abc97ab75
has only substance units: false
is: SBO:0000252
is encoded by: hsa:229
name: ALDOB
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: P05062

metaM ala L c
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
has only substance units: false
is: HMDB00161
is: CHEBI:16977
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: L-alanine

http://identifiers.org/biomodels.db/MODEL1310110036#_985ccd34_682e_4bd7_9631_43c3521a9098
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: ST3GAL1
is: Q11201
initial amount: NaN
is encoded by: hsa:6482

metaM tmndnccoa m
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB06514
name: timnodonyl coenzyme A
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0

metaR DINt
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
name: deoxyinosine transport via diffusion
product: MODEL1310110036#

metaR RE0452M
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
name: RE0452
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is: SBO:0000176
fast: false
type: Reaction

metaM dhcrm hs c
boundary condition: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
is: SBO:0000247
is: CHEBI:31488
name: dihydroceramide
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM pan4p c
name: Pantetheine 4'-phosphate
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:47942
has only substance units: false
initial concentration: 1.0
is: C01134
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_035f4c27_9c44_4396_a000_381038a9a47e
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI653169
is: SBO:0000252
boundary condition: true
name: _AI653169_1_c
initial concentration: NaN

metaR GLCt4
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
type: Reaction
is: SBO:0000185
name: glucose transport via sodium symport
reversible: true
product: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_d2e24878_88e3_4367_93db_4171e9a1b7cf
has only substance units: false
is encoded by: hsa:7298
constant: false
initial amount: NaN
is: P04818
boundary condition: true
initial concentration: NaN
name: TYMS
type: Species
is: SBO:0000252

metaM xol7aone r
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01993
initial amount: NaN
constant: false
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

metaM odecoa c
initial concentration: 1.0
has only substance units: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:3793
type: Species

metaM CE2420 m
initial amount: NaN
is: CHEBI:28387
has only substance units: false
is: SBO:0000247
is: HMDB11123
type: Species
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
initial concentration: 1.0
constant: false

metaM C04849 e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
type: Species
is: CHEBI:57449
initial amount: NaN
constant: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
initial concentration: 1.0

metaM adprib e
has only substance units: false
type: Species
name: D-ribofuranos-5-yl-ADP(2-)
is: CHEBI:57967
notes: FORMULA: C15H21N5O14P2 CHARGE: -2 INCHI: InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(23)8(21)5(32-14)1-30-35(26,27)34-36(28,29)31-2-6-9(22)11(24)15(25)33-6/h3-6,8-11,14-15,21-25H,1-2H2,(H,26,27)(H,28,29)(H2,16,17,18)/p-2/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C00301
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01178

metaR r1611
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#

metaR ACHEe
kinetic law: MODEL1310110036#
fast: false
reversible: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.1.7
type: Reaction
name: Acetylcholinesterase
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ

metaM h g
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
name: proton
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636

metaR r0998
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
is: SBO:0000185
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
is described by: ECO:0000000

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaR GULN3D
reversible: true
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110036#
fast: false
type: Reaction
reactant: MODEL1310110036#
name: L-gulonate 3-dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110036#_ddccefd7_d41b_4e9d_bcaa_1323d6caa6a1
is encoded by: hsa:218
is: SBO:0000252
has only substance units: false
name: ALDH3A1
initial concentration: NaN
initial amount: NaN
is: P30838
boundary condition: true
constant: false
type: Species

metaM ptrc e
is: SBO:0000247
is: HMDB01414
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: C00134
is: CHEBI:326268
name: Putrescine
boundary condition: false
has only substance units: false
constant: false

metaM pi g
is: HMDB00973
is: SBO:0000247
initial concentration: 1.0
name: hydrogenphosphate
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:43474
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR SUCCOAPET
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_fa8fbb0e_2b55_40d7_8b82_b615806da437
boundary condition: true
initial amount: NaN
has only substance units: false
name: DGKD
initial concentration: NaN
is: Q16760
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:8527

metaR NADtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
fast: false
reversible: true
name: transport of NAD into peroxisome

http://identifiers.org/biomodels.db/MODEL1310110036#_6dbbe0b4_ab33_40b3_b46a_5aa4b947a8d2
initial concentration: NaN
name: UGP2
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:7360
type: Species
is: Q16851
boundary condition: true
is: SBO:0000252

metaR SARDHm
is described by: ECO:0000269
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.99.1
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
is: SBO:0000176
name: Sarcosine dehydrogenase (m)

metaM CE0713 m
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB02329
is: CHEBI:30623
name: 3-oxolinoleoyl-CoA
boundary condition: false
constant: false
initial concentration: 1.0

metaM ach n
is: HMDB00895
is: CHEBI:15355
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
type: Species

metaM ala L e
type: Species
initial amount: NaN
name: L-alanine
is: HMDB00161
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: CHEBI:16977
initial concentration: 1.0
constant: false
has only substance units: false

metaM Lkynr c
name: L-kynurenine
is: HMDB00684
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
type: Species
initial amount: NaN
is: CHEBI:16946
is: SBO:0000247
initial concentration: 1.0

metaM 3hibutcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
name: (S)-3-Hydroxyisobutyryl-CoA
boundary condition: false
is: CHEBI:28259
type: Species
is: HMDB01052
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false

metaM fad m
type: Species
is: CHEBI:16238
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
is: HMDB01248
is: C00016
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized

metaM crn c
is: HMDB00062
name: L-Carnitine
constant: false
is: CHEBI:16347
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
type: Species
initial amount: NaN
has only substance units: false

metaR OMHPALTD
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM dpcoa m
is: CHEBI:57328
is: HMDB01373
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
type: Species
name: 3'-dephospho-CoA(2-)
is: SBO:0000247
initial amount: NaN

metaM pan4p e
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
initial amount: NaN
name: Pantetheine 4'-phosphate
boundary condition: false
is: CHEBI:47942
is: C01134
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01416

metaM ile L m
has only substance units: false
is: HMDB00172
name: L-isoleucine
is: CHEBI:17191
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
type: Species
constant: false

metaR FAOXC80
fast: false
is: SBO:0000176
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
name: Beta oxidation of med/long chain fatty acid
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110036#_96692657_00a4_4f94_b18a_a3a279c67fa5
constant: false
boundary condition: true
type: Species
is: O95470
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: SGPL1
is encoded by: hsa:8879
has only substance units: false

metaR r1941
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
reversible: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_104ec75c_b13c_49db_9454_7f5dcb8a7533
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC15A2
is: Q16348
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:6565
initial amount: NaN

metaR 3MOBt2im
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
reversible: false
is: SBO:0000185
product: MODEL1310110036#
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110036#_f95dd14a_5c6f_4113_bd4e_60ccc6fc2161
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: UCKL1
is encoded by: hsa:54963
is: Q53HM1
initial amount: NaN

metaM cholcoa c
type: Species
has only substance units: false
initial amount: NaN
name: choloyl-CoA(4-)
boundary condition: false
is: CHEBI:57373
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
constant: false
is: SBO:0000247

metaM man c
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0
constant: false
boundary condition: false
name: D-Mannose
type: Species
initial amount: NaN
is: CHEBI:16024
is: HMDB00169
is: C00159
has only substance units: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_8a352937_485b_47dc_a665_cd71844da9c0
initial amount: NaN
is: P00491
constant: false
is encoded by: hsa:4860
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PNP
has only substance units: false
type: Species

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR ASCBt
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
name: L-ascorbate transport via facilitated diffusion
product: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_9fb1580f_0e06_4557_b368_7f46141f868c
has only substance units: false
constant: false
is: SBO:0000297
boundary condition: true
initial concentration: NaN
name: PIK3CA:PIK3R1
type: Species
is encoded by: hsa:5295
initial amount: NaN
has part: P27986

metaR GALSGLT1le
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_46b4609e_624c_4d8d_a84f_cf98d19bc2df
name: FOLR3
constant: false
is: SBO:0000252
is: Q05C14
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2352
initial amount: NaN
has only substance units: false

metaR ACOAD9m
is: SBO:0000176
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is described by: ECO:0000269
reversible: false
product: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110036#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial

metaR TRPO2
fast: false
is described by: ECO:0000269
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.13.11.11
is: SBO:0000176
notes: GENE_ASSOCIATION: (6999.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES:NCD
modifier: MODEL1310110036#
reversible: false
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
kinetic law: MODEL1310110036#
type: Reaction

metaM HC00250 c
has only substance units: false
initial amount: NaN
is: CHEBI:29919
initial concentration: 1.0
name: hydrosulfide
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283

metaR RE1448N
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
kinetic law: MODEL1310110036#
fast: false
type: Reaction
reactant: MODEL1310110036#
reversible: true
name: RE1448
product: MODEL1310110036#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_c7daa003_886f_483c_81fd_2d6ab25200e7
is encoded by: hsa:9380
initial concentration: NaN
boundary condition: true
is: Q9UBQ7
initial amount: NaN
name: GRHPR
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaM dad 2 c
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 2-deoxyadenosine
is: CHEBI:17256
is: HMDB00101
boundary condition: false

metaR r2333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

metaM ca2 e
is: CHEBI:29108
name: calcium(2+)
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaM CE4790 m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
has only substance units: false
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_b27c333e_60e4_40a9_9dc0_bdf00a117bfe
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:1103
name: CHAT
initial amount: NaN
constant: false
is: Q6LEN6
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_5769044d_0059_45f8_ba8c_ff0c89a31afe
is encoded by: hsa:5019
name: OXCT1
type: Species
constant: false
is: P55809
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_74c6b277_f581_4967_90e5_7897dcda0a9f
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10400
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PEMT

http://identifiers.org/biomodels.db/MODEL1310110036#_82ff1456_8ccb_4015_b49b_9a15d07dc8e5
is encoded by: hsa:5295
has part: E7EX19
name: PIK3CD:PIK3R1
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000297
constant: false

metaM pi r
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:43474
is: C00009
has only substance units: false
type: Species
is: HMDB00973
name: hydrogenphosphate
initial concentration: 1.0
constant: false

metaM lnlnca c
is: HMDB01388
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: alpha-linolenate

metaR r2334
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0616
reactant: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
is: SBO:0000176
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
reversible: true
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

metaM leuktrF4 c
is: CHEBI:27491
has only substance units: false
initial concentration: 1.0
is: HMDB06465
type: Species
initial amount: NaN
constant: false
name: leukotriene F4
boundary condition: false
is: SBO:0000247
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_c9545b6e_1edf_42f5_b312_5c8bf035314d
is encoded by: hsa:7167
initial concentration: NaN
type: Species
name: TPI1
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q53HE2
constant: false
is: SBO:0000252

metaM man e
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00169
is: C00159
is: CHEBI:16024
name: D-Mannose
is: SBO:0000247
has only substance units: false

metaR r0841
name: Free diffusion
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.271
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_90242e95_8ead_46ff_aae3_e46fe8affb3d
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: HMGCS1
is encoded by: hsa:3157
is: Q01581
constant: false

metaM HC01444 e
name: Galactosylglycerol
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:15754
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401

http://identifiers.org/biomodels.db/MODEL1310110036#_bbc5284f_2d3b_4e4e_83ec_40148e27f34c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PFKM
type: Species
is encoded by: hsa:5213
boundary condition: true
initial amount: NaN
constant: false
is: P08237

metaM fad r
name: Flavin adenine dinucleotide oxidized
type: Species
boundary condition: false
is: CHEBI:16238
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
has only substance units: false
is: SBO:0000247
is: HMDB01248

http://identifiers.org/biomodels.db/MODEL1310110036#_cd52618d_27e6_462d_b41a_ca84fc940799
is encoded by: hsa:144195
is: Q8TDB8
constant: false
name: SLC2A14
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM dad 2 e
constant: false
boundary condition: false
type: Species
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: SBO:0000247
initial concentration: 1.0
is: HMDB00101
is: CHEBI:17256
name: 2-deoxyadenosine
initial amount: NaN
has only substance units: false

metaM ca2 c
boundary condition: false
has only substance units: false
is: CHEBI:29108
initial concentration: 1.0
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
is: HMDB00464
constant: false
initial amount: NaN
is: SBO:0000247
type: Species

metaM pail5p hs n
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57795
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3

metaR r0840
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.70
fast: false
name: Free diffusion
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reactant: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
reversible: true
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM h c
is: SBO:0000247
name: proton
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
is: CHEBI:24636
initial concentration: 1.0
constant: false
is: C00080

metaM retinol 9 cis c
is: SBO:0000247
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: CHEBI:17336
type: Species
boundary condition: false
initial amount: NaN
name: 9-cis-retinol
initial concentration: 1.0
has only substance units: false
is: HMDB06217

metaR ASCBt4
is described by: ECO:0000269
product: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
name: L-ascorbate transport via proton symport
reversible: true

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_efb0a6a1_f432_4767_9ece_7d28b0933933
has only substance units: false
is encoded by: hsa:3028
boundary condition: true
type: Species
name: HSD17B10
is: Q99714
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_003e63c4_d09f_49e3_b3ad_048d05b7e384
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: _AW299740_1_m
boundary condition: true
initial amount: NaN
is encoded by: hsa:AW299740
is: SBO:0000252

metaR EHGLATm
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reactant: MODEL1310110036#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is described by: ECO:0000212
is: SBO:0000176
product: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction

metaR FUMTSULtm
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
reversible: true
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
name: Fumarate:thiosulfate antiport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110036#_cf104470_844a_4230_bce3_6d0f457764ff
name: COX8C
boundary condition: true
initial amount: NaN
is: Q7Z4L0
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:341947

metaR DNDPt25m
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
type: Reaction
reversible: false
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
name: dTDP transport via dCDP antiport

http://identifiers.org/biomodels.db/MODEL1310110036#_761802f1_9191_4e92_96ca_d80d4c18ce6a
is: P49915
is encoded by: hsa:8833
name: GMPS
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM xol7aone c
boundary condition: false
constant: false
is: HMDB01993
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
initial concentration: 1.0
is: CHEBI:17899
has only substance units: false
type: Species
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247

metaM leuktrF4 e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27491
boundary condition: false
is: HMDB06465
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
has only substance units: false
name: leukotriene F4
constant: false

metaM odecoa r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
is: CHEBI:57387
is: HMDB01322
name: oleoyl-CoA(4-)
constant: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR HMGLx
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.3.4
modifier: MODEL1310110036#
name: hydroxymethylglutaryl-CoA lyase
kinetic law: MODEL1310110036#
fast: false
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110036#_1e9311c0_440a_4e90_98d6_9531c9cd4470
name: GCDH
type: Species
is encoded by: hsa:2639
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q92947
initial concentration: NaN
has only substance units: false
constant: false

metaM HC01115 c
initial amount: NaN
is: SBO:0000247
is: CHEBI:29025
initial concentration: 1.0
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
constant: false
name: NeuNGc
boundary condition: false
has only substance units: false
type: Species

metaR r1587
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a33bc6a4_6efc_4f62_9b0d_451b86ee220e
is: A6NFM2
has only substance units: false
name: PYCR1
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5831
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_9916c00c_ccb0_4253_8207_06b773daad19
is: Q8IZH9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:2643
has only substance units: false
type: Species
name: GCH1

metaR C4STMO1r
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.72
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
product: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR DOPAtu
product: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
fast: false
name: Dopamine uniport
kinetic law: MODEL1310110036#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaM duri n
is: CHEBI:16450
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00012
initial concentration: 1.0
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
has only substance units: false
type: Species
initial amount: NaN
name: 2'-deoxyuridine

metaM lnlncg e
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial amount: NaN
is: HMDB03073
has only substance units: false
is: CHEBI:32391
is: SBO:0000247
constant: false
boundary condition: false
name: gamma-linolenate
type: Species

metaR r1723
reversible: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000

metaM 2hb e
boundary condition: false
type: Species
constant: false
name: 2-Hydroxybutyrate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial amount: NaN
is: CHEBI:1148
initial concentration: 1.0
is: HMDB00008

metaM k c
type: Species
is: C00238
is: HMDB00586
initial concentration: 1.0
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
boundary condition: false
is: CHEBI:29103
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaR r1177
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110036#
product: MODEL1310110036#
name: EC:3.1.1.13
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
type: Reaction
is described by: ECO:0000000

metaM pi m
constant: false
is: C00009
boundary condition: false
is: HMDB00973
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:43474
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_80a4aa69_d4df_4d17_91b9_0c4a6ee8ecac
constant: false
has only substance units: false
type: Species
is encoded by: hsa:8170
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q15849
name: SLC14A2

metaM andrstandn r
is: CHEBI:15994
initial amount: NaN
has only substance units: false
is: HMDB00899
is: SBO:0000247
type: Species
name: 5alpha-androstane-3,17-dione
constant: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
boundary condition: false

metaR r2109
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM chol n
initial amount: NaN
is: CHEBI:15354
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00097
is: SBO:0000247
name: choline
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaR r1588
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM dpcoa c
is: C00882
boundary condition: false
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
has only substance units: false
initial amount: NaN
is: CHEBI:57328
name: Dephospho-CoA
is: HMDB01373
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r0242
type: Reaction
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:

metaR DDPGAm
is: SBO:0000176
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
fast: false

metaR r2330
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#

metaR LTC4CP
reversible: true
fast: false
name: Leukotriene C4 carboxypeptidase
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000176

metaR MI1345PP
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.3.86
product: MODEL1310110036#
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD

metaM pi n
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
is: HMDB00973
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:43474
is: SBO:0000247
name: hydrogenphosphate

metaM gchola e
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C26H43NO6 CHARGE: 0
type: Species
initial amount: NaN
name: glycocholate
is: SBO:0000247
constant: false
is: HMDB00138

metaM ipdp x
name: isopentenyl diphosphate(3-)
is: CHEBI:128769
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
is: SBO:0000247
is: HMDB01347
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r2108
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is: SBO:0000185

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_8e38bee1_88d2_4dae_8963_e4e449874f16
is: P21399
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: ACO1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:48

http://identifiers.org/biomodels.db/MODEL1310110036#_5869944f_b491_4348_a769_46aa190cd23a
has part: P31040
is encoded by: hsa:6389
name: SDHA:SDHB:SDHC:SDHD
has only substance units: false
initial concentration: NaN
has part: O14521
type: Species
has part: Q99643
has part: P21912
is: SBO:0000297
boundary condition: true
is encoded by: hsa:6392
is encoded by: hsa:6391
constant: false
is encoded by: hsa:6390
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_9f32de59_0f67_4d8a_880e_5dc1dd558570
boundary condition: true
constant: false
is: Q96CA6
type: Species
is encoded by: hsa:30
name: ACAA1
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR OCDCAtr
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110036#_4712c2d1_31a1_452f_8981_0b31dc51acd8
is: SBO:0000252
boundary condition: true
name: NDUFS8
initial concentration: NaN
is encoded by: hsa:4728
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: O00217

metaR DHORTS
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000269
type: Reaction
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.1.3.2
name: dihydroorotase
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is: SBO:0000176
modifier: MODEL1310110036#
fast: false

metaR UDPG4E
is version of: http://identifiers.org/ec-code/5.1.3.2
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
name: UDPglucose 4-epimerase

metaR r1721
is described by: ECO:0000000
reactant: MODEL1310110036#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_04c4bcc6_776d_44dc_9d2e_5265dc10150b
type: Species
is encoded by: hsa:53
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: E9PCI1
constant: false
name: ACP2
boundary condition: true

metaR SPHK21c
name: sphingosine kinase 2
fast: false
is described by: ECO:0000269
modifier: MODEL1310110036#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.91
type: Reaction
product: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ

metaR CITtbm
type: Reaction
reactant: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
reversible: true
product: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110036#
name: citrate transport, mitochondrial
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF

http://identifiers.org/biomodels.db/MODEL1310110036#_0a70982e_eb17_412f_8e62_868fc4e99740
type: Species
constant: false
is encoded by: hsa:3158
name: HMGCS2
is: P54868
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR FAOXC180
is described by: ECO:0000269
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110036#
modifier: MODEL1310110036#
name: Beta oxidation of long chain fatty acid
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000176

metaR r0990
fast: false
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true

metaM 2hb c
is: SBO:0000247
is: HMDB00008
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
boundary condition: false
name: 2-Hydroxybutyrate
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:1148

metaR r2331
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110036#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_1e4377ec_d254_4e20_9bc1_a5e768e9b700
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ALDH9A1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:223
type: Species
is: P49189
constant: false

metaM lnlncg c
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: SBO:0000247
type: Species
initial amount: NaN
name: gamma-linolenate
is: CHEBI:32391
has only substance units: false
is: HMDB03073

http://identifiers.org/biomodels.db/MODEL1310110036#_72222976_881c_4d87_8f55_94b94b742b23
has only substance units: false
name: ST8SIA1
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q92185
is encoded by: hsa:6489
boundary condition: true
type: Species
initial amount: NaN

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_c10419e3_c084_4ffc_bd8a_9f088df61811
type: Species
name: B3GNT3
initial amount: NaN
is: Q9Y2A9
boundary condition: true
has only substance units: false
is encoded by: hsa:10331
is: SBO:0000252
constant: false
initial concentration: NaN

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR LSTO1r
is version of: http://identifiers.org/ec-code/1.14.21.6
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110036#
name: Lathosterol oxidase
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
reversible: false
fast: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_eb42f55d_90c2_43b2_b1e9_b9f39a763f02
initial amount: NaN
constant: false
is: Q9NRA2
has only substance units: false
is encoded by: hsa:26503
type: Species
boundary condition: true
initial concentration: NaN
name: SLC17A5
is: SBO:0000252

metaR r2107
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
is: SBO:0000185
reversible: true
modifier: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110036#

metaR OCOAT1m
is version of: http://identifiers.org/ec-code/2.8.3.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
is described by: ECO:0000269
modifier: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
name: 3-oxoacid CoA-transferase
product: MODEL1310110036#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_2a229742_07e9_4e5c_9f13_a3b779a6d1b6
is: Q96CA6
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:30
type: Species
has only substance units: false
boundary condition: true
name: ACAA1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_f1b04d75_f9a9_4152_9e30_8769b1f5901c
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: P00558
boundary condition: true
is encoded by: hsa:5230
is: SBO:0000252
initial concentration: NaN
name: PGK1

metaM odecoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
name: Octadecenoyl-CoA (n-C18:1CoA)
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57387
type: Species
initial concentration: 1.0
is: HMDB01322
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_54ab78dd_a222_4a59_a450_bf6a0b7fb72b
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: E7ET30
constant: false
type: Species
name: AK3
is encoded by: hsa:50808

metaM dpcoa e
initial concentration: 1.0
is: C00882
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:57328
constant: false
is: HMDB01373
has only substance units: false
is: SBO:0000247
name: Dephospho-CoA
notes: FORMULA: C21H33N7O13P2S CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110036#_4961cf1e_ea9b_4f9f_850c_0fbab72aa2f3
initial concentration: NaN
is: P30837
type: Species
is encoded by: hsa:219
name: ALDH1B1
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR r0614
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#

metaR r2332
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110036#
type: Reaction
fast: false
reactant: MODEL1310110036#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185

metaR biomass reaction
name: biomass_reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000134
reversible: false
fast: false
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_87da6e9f_e706_43da_979f_f07c16ec1f12
is: O95992
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:9023
name: CH25H
type: Species
initial concentration: NaN

metaM lnlnca e
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01388
type: Species
name: alpha-linolenate

http://identifiers.org/biomodels.db/MODEL1310110036#_6bf3abe6_6657_41f2_9edc_15d3e5da9256
boundary condition: true
name: _H53099_1_m
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:H53099
initial concentration: NaN

metaR RE2649M
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
name: RE2649
fast: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_6374108f_0c6a_4d3f_876f_553095f3cc0c
type: Species
has only substance units: false
is encoded by: hsa:5335
initial concentration: NaN
initial amount: NaN
is: P19174
boundary condition: true
is: SBO:0000252
constant: false
name: PLCG1

http://identifiers.org/biomodels.db/MODEL1310110036#_416683a5_d688_4641_ac5c_916ffbfd9da9
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4907
boundary condition: true
type: Species
constant: false
name: NT5E
is: P21589

metaR DPCOAK
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.3
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110036#
name: dephospho-CoA kinase
fast: false
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_c42f4859_806e_4cee_a5c1_15562fa11eff
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:10327
initial amount: NaN
initial concentration: NaN
name: AKR1A1
type: Species
is: SBO:0000252

metaM tchola c
is: SBO:0000247
initial amount: NaN
name: taurocholic acid
is: CHEBI:36257
boundary condition: false
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0
has only substance units: false
constant: false
type: Species

metaM gchola c
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
name: glycocholate
initial amount: NaN
is: HMDB00138
has only substance units: false
is: CHEBI:58235
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaR r0813
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
product: MODEL1310110036#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_e390980b_ca58_439f_801f_a620147e8471
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM citr L e
is: CHEBI:16349
initial concentration: 1.0
name: citr_L[e]
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
type: Species
is: HMDB00904
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247

metaR DRPA
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
name: deoxyribose-phosphate aldolase
product: MODEL1310110036#

metaR r2115
reactant: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
reversible: true
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR VALTA
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: valine transaminase
kinetic law: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
is described by: ECO:0000269
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110036#
reversible: true
type: Reaction

metaM dtdp n
boundary condition: false
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaR r0021
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
modifier: MODEL1310110036#
is: SBO:0000176
reversible: true
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
fast: false
is described by: ECO:0000000

metaR r1598
product: MODEL1310110036#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NS26T2g
is: SBO:0000176
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.99.3
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
product: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_65f54b59_1552_43ff_b84b_c0a63d8ea3bc
constant: false
has only substance units: false
is: P08195
name: SLC3A2
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6520

metaR RAI1
name: retinal isomerase (11-cis)
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#

metaR PI345P3P
modifier: MODEL1310110036#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.3.67
reactant: MODEL1310110036#

metaM 42A3HP24DB c
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
has only substance units: false
is: C05645
type: Species
constant: false
is: SBO:0000247
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: http://identifiers.org/pubchem.compound/7956
is: HMDB04083
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_22308c92_04a3_4f86_81aa_e01aa0b5a289
name: HPGDS
is encoded by: hsa:27306
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is: O60760
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR LEUKTRE4t
product: MODEL1310110036#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110036#
name: leukotriene E4 transport

http://identifiers.org/biomodels.db/MODEL1310110036#_bd782d81_95db_4503_99e2_c41eca27d636
initial amount: NaN
boundary condition: true
name: COX6A2
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is: Q02221
is encoded by: hsa:1339
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_900afe37_6a54_42de_88fd_8b9d4fe53fd5
boundary condition: true
constant: false
name: _AI656480_1_m
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI656480
is: SBO:0000252

metaR r0812
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
modifier: MODEL1310110036#
product: MODEL1310110036#

metaR ADK1
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: adenylate kinase
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110036#

metaR r2116
is: SBO:0000185
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_884c4e0b_e4b4_4012_b3ca_4ae75fe8ba03
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: P14618
is: SBO:0000252
initial amount: NaN
name: PKM2
has only substance units: false
is encoded by: hsa:5315

metaM vitd3 c
type: Species
is: CHEBI:28940
name: calciol
boundary condition: false
is: HMDB00876
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial amount: NaN

metaR UPPN
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.1.6
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
name: b-ureidopropionase
product: MODEL1310110036#
reversible: false

metaR LCADi
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
name: lactaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304
fast: false
is: SBO:0000176

metaR SUCOAS1m
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110036#
product: MODEL1310110036#
name: Succinate--CoA ligase (GDP-forming)

metaM dtdp m
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: HMDB01274
is: CHEBI:58369
initial amount: NaN
has only substance units: false
is: C00363
type: Species
is: SBO:0000247
constant: false
name: dTDP

http://identifiers.org/biomodels.db/MODEL1310110036#_b72b39ba_2030_445a_b4a6_a93466d4e100
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:4729
type: Species
name: NDUFV2
initial amount: NaN
initial concentration: NaN
is: P19404

metaM ru5p D r
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: D-ribulose 5-phosphate(2-)
is: CHEBI:58121
has only substance units: false
is: HMDB00618
is: SBO:0000247

metaM adp r
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
constant: false
is: CHEBI:456216
initial concentration: 1.0
initial amount: NaN
is: HMDB01341
type: Species
name: ADP(3-)
has only substance units: false

metaM 4abutn m
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
is: CHEBI:58264
boundary condition: false
is: SBO:0000247
name: 4-ammoniobutanal

http://identifiers.org/biomodels.db/MODEL1310110036#_af19cc4b_c771_4d33_afe4_65ed65f9aa2c
has only substance units: false
is: SBO:0000252
type: Species
is: Q9NQR4
constant: false
is encoded by: hsa:56954
initial amount: NaN
initial concentration: NaN
name: NIT2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_9129642b_b040_4e59_a609_a05564ba592b
has only substance units: false
is: SBO:0000252
is encoded by: hsa:39
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
name: ACAT2
is: Q9BWD1
type: Species

metaR r1597
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: true
product: MODEL1310110036#
is: SBO:0000185

metaM lac L c
has only substance units: false
initial amount: NaN
is: CHEBI:16651
constant: false
initial concentration: 1.0
type: Species
name: (S)-lactate
boundary condition: false
is: HMDB00190
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177

metaR RAI2
fast: false
name: retinal isomerase (9-cis)
is: SBO:0000176
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
type: Reaction

metaR PRPPS
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.6.1
reversible: true
is described by: ECO:0000000
name: phosphoribosylpyrophosphate synthetase
kinetic law: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
fast: false

metaR FRDPtc
is described by: ECO:0000000
fast: false
product: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110036#
reversible: true
name: lipid, flip-flop intracellular transport

metaM citr L c
is: CHEBI:16349
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
name: L-citrulline
has only substance units: false
type: Species
is: HMDB00904
initial amount: NaN
constant: false

metaR r2061
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
fast: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR r0822
kinetic law: MODEL1310110036#
is: SBO:0000185
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
modifier: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_4f47d82d_e02e_4954_8c54_ed9c3beb01c0
is: P00813
name: ADA
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:100

http://identifiers.org/biomodels.db/MODEL1310110036#_c2c0731a_8fdf_4070_a5c7_b9cb581a1830
initial amount: NaN
is encoded by: hsa:7296
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is: Q16881
name: TXNRD1
boundary condition: true

metaR r2139
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110036#
reversible: true

metaM ibcoa m
is: CHEBI:57338
initial amount: NaN
name: isobutyryl-CoA(4-)
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: HMDB01243
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
type: Species

metaM cytd c
constant: false
is: CHEBI:17562
is: C00475
name: Cytidine
is: HMDB00089
is: SBO:0000247
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

metaR UGLT
reversible: true
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.7.12
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
name: UDPglucose--hexose-1-phosphate uridylyltransferase
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000176
product: MODEL1310110036#

metaM ile L c
name: L-isoleucine
is: SBO:0000247
is: HMDB00172
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
is: CHEBI:17191

http://identifiers.org/biomodels.db/MODEL1310110036#_04a0fcd4_5918_45ec_8825_c8682ebddd86
is: E9PB82
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3295
initial amount: NaN
has only substance units: false
name: HSD17B4
constant: false
type: Species

metaR r2117
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR H2O2syn
reversible: false
is version of: http://identifiers.org/ec-code/1.6.3.1
reactant: MODEL1310110036#
name: Hydrogen peroxide synthesis (NADPH dependent)
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000176
type: Reaction

metaR CHOLtu
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110036#
reversible: true
name: Choline uniport
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
fast: false
modifier: MODEL1310110036#

metaR CYSGLUexR
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
name: L-cysteine/L-glutamine reversible exchanger
product: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#

metaR r1596
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM mthgxl e
is: CHEBI:17158
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
type: Species
has only substance units: false
name: methylglyoxal
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01167

http://identifiers.org/biomodels.db/MODEL1310110036#_8b9d51c7_bbfa_4fe7_85d4_7f7401f8f910
is: P48735
boundary condition: true
initial concentration: NaN
name: IDH2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3418
constant: false
initial amount: NaN
type: Species

metaR RE1534M
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110036#
reversible: true
type: Reaction
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1534

metaM occoa x
initial amount: NaN
constant: false
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
is: CHEBI:57386
is: C01944
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d45f86d3_368a_465a_ba84_b0d7d109b5b6
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: SLC24A4
initial concentration: NaN
is encoded by: hsa:123041

http://identifiers.org/biomodels.db/MODEL1310110036#_2e9b9a9b_3a46_4e62_ae9f_b9018bdf64f3
is encoded by: hsa:6523
initial concentration: NaN
name: SLC5A1
is: P13866
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaM pac c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00209
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
constant: false
is: CHEBI:18401
type: Species
name: phenylacetate

metaM vitd3 e
constant: false
has only substance units: false
name: calciol
type: Species
initial concentration: 1.0
is: CHEBI:28940
initial amount: NaN
is: SBO:0000247
is: HMDB00876
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_b25846d3_8d8c_4e3b_94a9_9125ead3b69b
constant: false
is: SBO:0000252
is: P49619
has only substance units: false
is encoded by: hsa:1608
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: DGKG

metaR SERtN1
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
is described by: ECO:0000269
reactant: MODEL1310110036#
reversible: true
name: Serine transport (Na, H coupled)
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#

metaR CYTK14
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (dCMP,UTP)
reversible: true
reactant: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110036#
fast: false

metaR ADSS
name: adenylosuccinate synthase
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reversible: false
is: SBO:0000176
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.3.4.4
product: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_bc83ed9e_3a01_4e89_9c2c_4a38f5a50909
boundary condition: true
type: Species
initial amount: NaN
has part: Q92569
is encoded by: hsa:8503
name: PIK3CD:PIK3R3
initial concentration: NaN
is: SBO:0000297
has only substance units: false
has part: A7E2E0
is encoded by: hsa:5293
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_195d03e3_ebd9_40f1_aa12_3cef82b8afc9
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: _AI972237_1_c
is encoded by: hsa:AI972237
constant: false
is: SBO:0000252
has only substance units: false

metaR r1500
is: SBO:0000185
product: MODEL1310110036#
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
fast: false
is described by: ECO:0000000

metaR r2118
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110036#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
is: SBO:0000185

metaR ADK3
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: adentylate kinase (GTP)
is: SBO:0000176
modifier: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
type: Reaction
fast: false
is described by: ECO:0000269

metaR CO2t
reversible: true
is described by: ECO:0000000
type: Reaction
name: CO2 transporter via diffusion
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is: SBO:0000185
product: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR r1595
is: SBO:0000185
reversible: true
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000

metaR LNLNCGt
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110036#
type: Reaction
reversible: true
name: fatty acid transport via diffusion
kinetic law: MODEL1310110036#

metaR AACOAT
reactant: MODEL1310110036#
name: Acetoacetyl-CoA:acetate CoA-transferase
reversible: true
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
modifier: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.16
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_4b642926_d6f0_42ad_a639_1acce4945d56
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9NRA0
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:56848
constant: false
type: Species
name: SPHK2

http://identifiers.org/biomodels.db/MODEL1310110036#_aaab2c84_77c5_4fc4_92a0_1f2c61269949
name: GPX2
initial concentration: NaN
is: SBO:0000252
is: P18283
constant: false
has only substance units: false
is encoded by: hsa:2877
boundary condition: true
type: Species
initial amount: NaN

metaR r0573
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
name: Cholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:438652 NOTES:
is: SBO:0000176
reversible: true

metaR r2329
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_636e957f_7f73_43d0_b478_0e60ff89e194
constant: false
boundary condition: true
is encoded by: hsa:10935
initial concentration: NaN
is: P30048
type: Species
is: SBO:0000252
name: PRDX3
has only substance units: false
initial amount: NaN

metaM ura c
name: Uracil
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17568
is: C00106
is: HMDB00300

metaR GLYCLTtp
reactant: MODEL1310110036#
name: glycolate transport into peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110036#
reversible: false

metaM lac L e
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
is: HMDB00190
constant: false
has only substance units: false
name: (S)-lactate
is: CHEBI:16651
type: Species

metaM HC00591 c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: CHEBI:16769
type: Species
boundary condition: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_f5d30773_6adc_40f2_9723_88a5a632fad2
type: Species
is: SBO:0000252
boundary condition: true
is: P22033
initial amount: NaN
is encoded by: hsa:4594
initial concentration: NaN
constant: false
has only substance units: false
name: MUT

metaR CYTK13
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110036#
name: cytidylate kinase (dCMP,dATP)
product: MODEL1310110036#
reversible: true

metaR r2111
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
is: SBO:0000185
fast: false

metaR r2137
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true

metaR HIBDm
is version of: http://identifiers.org/ec-code/1.1.1.31
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
modifier: MODEL1310110036#
is described by: ECO:0000269
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_f998d055_3835_4992_9844_5d92af4c9c54
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:158
initial concentration: NaN
is: SBO:0000252
name: ADSL

metaR KCCt
modifier: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
reversible: true
name: K+-Cl- cotransport
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_44c1b808_0e72_4a43_b66c_bd88b4261c67
initial concentration: NaN
constant: false
initial amount: NaN
name: HADHA
has only substance units: false
type: Species
is: SBO:0000252
is: E9KL44
boundary condition: true
is encoded by: hsa:3030

metaR r0236
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reactant: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
modifier: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000

metaR r2328
fast: false
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1019
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
fast: false
type: Reaction
product: MODEL1310110036#

metaR 5ADTSTSTERONESte
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
name: sulfonated testosterone transport
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM L2aadp c
name: L-2-aminoadipate(1-)
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:58672
boundary condition: false
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false

metaR r1594
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_2fdd2f45_7724_4148_9dce_f4e83521909d
boundary condition: true
name: COX7C
is: P15954
is: SBO:0000252
is encoded by: hsa:1350
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaR CYTK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000269
reversible: true
type: Reaction
name: cytidylate kinase (CMP,UTP),nuclear
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#

metaM itp e
name: ITP(3-)
is: HMDB00189
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
is: CHEBI:57614
initial amount: NaN
has only substance units: false

metaR GAPD
fast: false
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is version of: http://identifiers.org/ec-code/1.2.1.12
kinetic law: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
name: glyceraldehyde-3-phosphate dehydrogenase
is described by: ECO:0000134
type: Reaction
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#

metaR HISTAtu
kinetic law: MODEL1310110036#
is described by: ECO:0000269
name: Histamine uniport
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
is: SBO:0000185
type: Reaction

metaR ABTti
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: false
name: L-arabinitol transport via passive diffusion
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185

metaM ala B m
initial concentration: 1.0
has only substance units: false
is: CHEBI:16958
type: Species
is: SBO:0000247
boundary condition: false
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN
constant: false
is: HMDB00056

metaR r2112
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
modifier: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR CYTK12
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110036#
name: cytidylate kinase (dCMP,dCTP)
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r0821
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
fast: false
product: MODEL1310110036#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

http://identifiers.org/biomodels.db/MODEL1310110036#_0766ab7a_a7f6_49dc_aa35_9fc5d9ea6837
has only substance units: false
initial amount: NaN
is: P47895
type: Species
name: ALDH1A3
is encoded by: hsa:220
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR SIAT9g
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.9
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
reactant: MODEL1310110036#
modifier: MODEL1310110036#

metaM tdcoa x
is: CHEBI:57385
is: SBO:0000247
is: C02593
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
is: HMDB01521
initial concentration: 1.0
has only substance units: false
constant: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
boundary condition: false
initial amount: NaN

metaM ura e
is: CHEBI:17568
initial amount: NaN
is: HMDB00300
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
has only substance units: false
boundary condition: false
name: uracil
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0

metaM 44mctr r
is: HMDB01023
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: CHEBI:17813
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
type: Species

metaR r0575
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.48
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176

metaR r1018
is: SBO:0000185
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
reversible: true
fast: false
is described by: ECO:0000000
name: Transport reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR r2327
is: SBO:0000185
reactant: MODEL1310110036#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110036#

metaR r1593
reversible: true
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_68677fd5_7974_41fd_9635_5c934619e4fb
constant: false
is: SBO:0000252
is: P49189
type: Species
name: ALDH9A1
initial concentration: NaN
is encoded by: hsa:223
has only substance units: false
boundary condition: true
initial amount: NaN

metaR NDP8ex
product: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
name: nucleoside-diphosphatase (UTP), extracellular
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110036#

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1f5d8902_d4de_4e6e_afbc_c4182c8d7512
constant: false
boundary condition: true
is encoded by: hsa:J03866
type: Species
initial amount: NaN
initial concentration: NaN
name: _J03866_1_m
is: SBO:0000252
has only substance units: false

metaR r2471
reversible: false
is: SBO:0000185
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
kinetic law: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110036#

metaR r2113
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
fast: false

metaR CYTK11
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110036#
fast: false
name: cytidylate kinase (dCMP,dGTP)
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_1ac58470_6dfd_42b0_acb4_b6add4035cb0
is: SBO:0000297
is encoded by: hsa:3073
initial concentration: NaN
has only substance units: false
initial amount: NaN
has part: P06865
type: Species
boundary condition: true
has part: P07686
name: HEXA:HEXB
is encoded by: hsa:3074
constant: false

metaR r0578
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reactant: MODEL1310110036#
reversible: true
type: Reaction
product: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.1.2.27
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaR r2326
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
type: Reaction

metaR NDPK6n
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is described by: ECO:0000304
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110036#
type: Reaction
reversible: true

metaR r1592
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM icit x
is: HMDB00193
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:16087
name: isocitrate(3-)
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

metaR SERDGLYexR
name: D-Serine/Glycine reversible exchange
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000304
reversible: true
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110036#

metaM 3ohdcoa x
type: Species
is: SBO:0000247
is: CHEBI:57349
has only substance units: false
name: 3-oxopalmitoyl-CoA(4-)
initial concentration: 1.0
constant: false
is: HMDB06402
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false

metaM nh4 x
initial amount: NaN
is: HMDB00051
has only substance units: false
name: Ammonium
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
boundary condition: false
is: C01342
is: CHEBI:28938
constant: false
is: SBO:0000247
type: Species

metaM itp c
initial amount: NaN
is: HMDB00189
initial concentration: 1.0
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57614
has only substance units: false
name: ITP(3-)

http://identifiers.org/biomodels.db/MODEL1310110036#_0c5d69e9_d90b_463d_a566_c9dee2236a59
is: Q9UBK5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10870
has only substance units: false
constant: false
name: HCST
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_a4a2beea_8fc6_4fbd_93eb_51fe6ccf01e1
initial amount: NaN
is: E9KL42
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ACOT1
type: Species
is encoded by: hsa:641371
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_37290a06_c1df_411d_b504_c22b8e21f3c4
is: SBO:0000252
initial concentration: NaN
is: B7Z5T8
is encoded by: hsa:1375
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: CPT1B

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR CYTK10
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110036#
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dGTP)
is described by: ECO:0000269

metaR URAt
is: SBO:0000185
is described by: ECO:0000269
fast: false
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: uracil transport via facilated diffusion
reversible: true
type: Reaction

metaR ACHtn
fast: false
reactant: MODEL1310110036#
name: Acetylcholin transport, nuclear trhough pores
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it

http://identifiers.org/biomodels.db/MODEL1310110036#_38ca3ef7_4153_4ee5_ac6d_00f80732a58a
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: E9PCP2
type: Species
name: CPT1B
is encoded by: hsa:1375

metaR r2136
modifier: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false

metaR r2325
reversible: true
fast: false
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_c3aabed7_ba88_4298_ae3c_d306d892e595
type: Species
is: Q92569
name: PIK3R3
is encoded by: hsa:8503
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR r1591
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM ump r
initial amount: NaN
boundary condition: false
name: UMP
is: CHEBI:57865
is: HMDB00288
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaM arachdcrn x
is: SBO:0000247
initial amount: NaN
name: C20:4 carnitine
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB06523
constant: false
boundary condition: false
is: CHEBI:57368

http://identifiers.org/biomodels.db/MODEL1310110036#_6c05ec91_ae78_46a5_a0a2_31e94f5d7218
has only substance units: false
is encoded by: hsa:51109
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: RDH11
initial amount: NaN
boundary condition: true
is: B4DDW0

metaR FAOXC18480m
is described by: ECO:0000000
name: Beta oxidation of fatty acid
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR FACOAL204
is: SBO:0000176
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
is described by: ECO:0000269
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
type: Reaction
fast: false
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110036#

metaM 4ppan c
is: C03492
constant: false
name: D-4'-Phosphopantothenate
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: HMDB01016
initial concentration: 1.0
type: Species
is: CHEBI:10986

http://identifiers.org/biomodels.db/MODEL1310110036#_d69ed588_431e_4631_9414_98f493ab9078
initial amount: NaN
has only substance units: false
name: _AI697028_1_m
is: SBO:0000252
is encoded by: hsa:AI697028
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaR r0022
is described by: ECO:0000000
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.7
reversible: true
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaR IDPtn
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185
reactant: MODEL1310110036#
product: MODEL1310110036#
name: IDP nuclear transport

metaR r1377
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_c50437ba_01af_471b_a0c5_bcb1dee2f886
is: SBO:0000252
is: P47895
initial concentration: NaN
is encoded by: hsa:220
type: Species
constant: false
name: ALDH1A3
initial amount: NaN
boundary condition: true
has only substance units: false

metaM hxan e
is: SBO:0000247
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: CHEBI:17368
boundary condition: false
type: Species
is: HMDB00157
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: hypoxanthine

metaM arachdcrn m
is: HMDB01322
name: C20:4 carnitine
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57387

http://identifiers.org/biomodels.db/MODEL1310110036#_19bc7e0f_663e_4adc_a666_f49e464d85ad
constant: false
type: Species
has only substance units: false
name: MYO5B
is: Q9H6Y6
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4645
initial concentration: NaN
initial amount: NaN

metaM ump m
initial concentration: 1.0
is: CHEBI:57865
has only substance units: false
type: Species
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00288

metaR NAHCO3 HCLt
product: MODEL1310110036#
is: SBO:0000185
name: bicarbonate transport (HCl/NaHCO3 exchange)
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
fast: false
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110036#

metaR r1590
reversible: true
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0345
fast: false
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
modifier: MODEL1310110036#
reversible: true
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_4006fbb1_6b55_4452_9258_68d2e151300b
is: SBO:0000252
type: Species
is: O75355
initial amount: NaN
constant: false
name: ENTPD3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:956
has only substance units: false

metaR r2133
is: SBO:0000185
kinetic law: MODEL1310110036#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_c746c82a_3f97_43c2_ba68_0edc1761d848
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: P51857
name: AKR1D1
is encoded by: hsa:6718
has only substance units: false
boundary condition: true

metaM 4abut c
is: HMDB00112
is: CHEBI:3628
type: Species
initial concentration: 1.0
name: 4-Aminobutanoate
has only substance units: false
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM ac e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
boundary condition: false
name: acetate
initial concentration: 1.0
is: HMDB00042
has only substance units: false
type: Species
constant: false

metaR RE2677E
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
reversible: false
is: SBO:0000176
type: Reaction
name: RE2677
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton

metaR PROSTGE2t2
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110036#
name: prostaglandin uniport
is: SBO:0000185
product: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#

metaM citr L m
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
is: CHEBI:16349
type: Species
is: HMDB00904
initial amount: NaN
name: L-citrulline
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false

metaM pi c
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: C00009
is: HMDB00973
is: SBO:0000247
name: hydrogenphosphate
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2
is: CHEBI:43474
has only substance units: false

metaR r1378
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
fast: false
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_fc278062_1d1a_44a8_880e_a18e45512326
constant: false
is encoded by: hsa:1738
is: P09622
name: DLD
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaM sphmyln hs g
name: sphingomyelin betaine
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
has only substance units: false
is: CHEBI:58216
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaR RBTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110036#
name: ribitol transport via passive diffusion
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: false
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_d2e1a801_39f3_4d12_80b8_038c3d46c396
has only substance units: false
initial concentration: NaN
constant: false
name: _7359_1_c
type: Species
is encoded by: hsa:7359
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM CE2417 m
type: Species
constant: false
is: HMDB11123
is: SBO:0000247
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
initial concentration: 1.0
has only substance units: false
is: CHEBI:28387
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial amount: NaN
boundary condition: false

metaR CHOLtn
is described by: ECO:0000000
name: Choline transport, nuclear through pores
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is: SBO:0000185
reversible: true
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
type: Reaction

metaM HC00591 m
name: 2-oxoglutaramate
boundary condition: false
is: CHEBI:16769
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial concentration: 1.0

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR r0579
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.19
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_da42ee34_c571_4636_b44e_2d3761d1e00f
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: P36969
name: GPX4
boundary condition: true
has only substance units: false
is encoded by: hsa:2879
constant: false

metaM 4abutn e
is: HMDB01080
initial amount: NaN
is: CHEBI:58264
name: 4-ammoniobutanal
type: Species
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaM duri c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Deoxyuridine
is: CHEBI:16450
is: HMDB00012
type: Species
is: C00526
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_2932b8d9_78d1_43bb_a5e3_29b1ac773637
is: SBO:0000297
name: PFKL:PFKP
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has part: Q7L2M7
has only substance units: false
is encoded by: hsa:5211

metaM tdcoa m
constant: false
initial concentration: 1.0
is: C02593
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
is: CHEBI:57385
name: Tetradecanoyl-CoA (n-C14:0CoA)
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaM hxan c
is: C00262
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
boundary condition: false
is: SBO:0000247
is: CHEBI:17368
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00157
name: Hypoxanthine
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_5eeff131_3289_4f31_a706_90928d2ac257
initial amount: NaN
is: B2RD24
name: MTHFD1L
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:25902

http://identifiers.org/biomodels.db/MODEL1310110036#_75652417_4296_471c_b41e_225add8e1d99
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:6389
is: P31040
constant: false
name: SDHA
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_9653e152_3238_4699_b1b4_6de373dcfbc9
type: Species
name: SLC2A4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6517
boundary condition: true
constant: false
is: P14672

http://identifiers.org/biomodels.db/MODEL1310110036#_871e9d9a_fc8f_4d9d_96e7_0c56c29a3f36
constant: false
boundary condition: true
is: SBO:0000252
name: PPA2
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:27068
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_873d8b8a_fe4d_4327_9115_2a1207de16ed
boundary condition: true
name: IDH1
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: O75874
is encoded by: hsa:3417
initial amount: NaN

metaM gal1p c
is: SBO:0000247
boundary condition: false
has only substance units: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
type: Species
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
is: CHEBI:58336
constant: false
is: HMDB00645
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_fa431b9b_87ad_4520_aec2_5a2cbe55027f
has part: O00330
is encoded by: hsa:1738
is encoded by: hsa:4967
is: SBO:0000297
type: Species
has only substance units: false
has part: P36957
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: DLD:DLST:OGDH:PDHX
has part: P09622
is encoded by: hsa:8050
has part: Q02218
is encoded by: hsa:1743

metaM 4abut e
is: HMDB00112
is: SBO:0000247
name: 4-Aminobutanoate
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: C00334
is: CHEBI:3628
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_7e432510_2ff9_4bb5_bbf7_b66ecd8ad955
boundary condition: true
is encoded by: hsa:1757
initial amount: NaN
is: A8K596
name: SARDH
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaR r0819
type: Reaction
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
modifier: MODEL1310110036#
fast: false
reversible: true
product: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110036#

metaR r2131
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110036#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR GCALDD
name: Glycolaldehyde dehydrogenase
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
reversible: false
modifier: MODEL1310110036#

metaM ac c
type: Species
constant: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
name: acetate
boundary condition: false
is: SBO:0000247
is: CHEBI:30089
initial concentration: 1.0
has only substance units: false
is: HMDB00042

metaR RE3520E
kinetic law: MODEL1310110036#
type: Reaction
reversible: true
product: MODEL1310110036#
fast: false
name: RE3520
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is version of: http://identifiers.org/ec-code/1.11.1.9
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_1b23a3f6_f2f3_4882_8a13_ae940e803cec
is: Q14542
name: SLC29A2
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:3177
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_e0afcdb7_a682_4dda_a8e8_ea16c7a1f933
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ALDH3B2
is: P48448
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:222

metaR BAMPPALDOX
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110036#
is described by: ECO:0000212
is: SBO:0000176
reactant: MODEL1310110036#
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
modifier: MODEL1310110036#
fast: false
type: Reaction

metaM 7dhchsterol c
name: cholesta-5,7-dien-3beta-ol
is: CHEBI:17759
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00032
boundary condition: false
type: Species

metaR RE2998M
type: Reaction
product: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110036#
name: RE2998
is: SBO:0000176
modifier: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_0d2599ac_298f_4f16_a8b1_ee143cdcb8bc
name: SLC2A10
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: O95528
is: SBO:0000252
is encoded by: hsa:81031
initial concentration: NaN
constant: false

metaM ump n
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
name: UMP(2-)
is: HMDB00288
boundary condition: false
is: CHEBI:57865
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaR RE2649C
product: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
name: RE2649
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#

metaR r2132
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185

metaR RE2349C
modifier: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
name: RE2349
reactant: MODEL1310110036#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C

metaM HC01415 m
is: CHEBI:27537
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: (2E)-Octenoyl-CoA
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_1edaa5b9_549a_4bf6_b619_7137d4aaba79
initial concentration: NaN
boundary condition: true
is: Q9Y5B8
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: NME7
is encoded by: hsa:29922

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR r2110
product: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b06737f2_f52c_4330_9054_74a50de54ccf
initial concentration: NaN
constant: false
name: ACSL4
type: Species
has only substance units: false
is: O60488
is encoded by: hsa:2182
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r0818
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110036#
product: MODEL1310110036#
name: Transport reaction
fast: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_39f1c4f8_92a5_4d36_bb55_b79b1cee54a9
constant: false
initial concentration: NaN
is: B4DK61
has only substance units: false
initial amount: NaN
name: ACOX1
is encoded by: hsa:51
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_1e3124a1_9558_4ead_a5e6_9c3efecfe992
initial amount: NaN
is encoded by: hsa:55825
is: SBO:0000252
has only substance units: false
name: PECR
boundary condition: true
constant: false
type: Species
is: Q9BY49
initial concentration: NaN

metaM CE5120 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: SBO:0000247
type: Species
is: CHEBI:57923
initial amount: NaN
boundary condition: false
name: trans-2-cis-8-tetradecadienoyl-CoA
constant: false
initial concentration: 1.0
has only substance units: false

metaR r1260
is: SBO:0000176
product: MODEL1310110036#
is described by: ECO:0000000
name: EC:6.2.1.3
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction

metaR r0463
is: SBO:0000176
fast: false
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: true
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10

http://identifiers.org/biomodels.db/MODEL1310110036#_b8b928cc_9e4c_43ac_8183_216fd1555e85
is: SBO:0000252
is encoded by: hsa:55191
is: Q6IA69
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: NADSYN1

metaR r0130
type: Reaction
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
reversible: true
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_f28d2499_bd37_48ae_a4e0_a366d1226ad3
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: ADSSL1
initial concentration: NaN
is: B3KTV4
boundary condition: true
is encoded by: hsa:122622
type: Species

metaM itp n
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00189
is: CHEBI:57614
type: Species
name: ITP(3-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
modifier: MODEL1310110036#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185

metaR MTHFCm
is described by: ECO:0000269
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
modifier: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.3.4.3
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
type: Reaction
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD

metaM nh4 m
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
type: Species
initial concentration: 1.0
name: Ammonium
is: CHEBI:28938
constant: false
is: HMDB00051
is: C01342
is: SBO:0000247
has only substance units: false

metaR r1949
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
reactant: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ile L e
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species
name: L-isoleucine
initial amount: NaN
is: HMDB00172
initial concentration: 1.0

metaR r1617
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_d8e1f947_f8e2_4958_9c23_f0f43e581b5f
type: Species
is: SBO:0000252
has only substance units: false
name: PCBD2
initial concentration: NaN
constant: false
is encoded by: hsa:84105
boundary condition: true
initial amount: NaN
is: Q9H0N5

metaR HISCAT1
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR VALATB0tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine into the intestinal cells by ATB0 transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_d4a66c6c_1d9e_4c3e_833f_e724bbbfcb58
name: NDUFB6
type: Species
initial concentration: NaN
is encoded by: hsa:4712
is: O95139
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true

metaM arachdcrn r
is: CHEBI:57368
initial amount: NaN
boundary condition: false
name: C20:4 carnitine
type: Species
is: HMDB06523
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236

metaR PRISTCOAtx
product: MODEL1310110036#
fast: false
name: pristcoa peroxisomal transport
is described by: ECO:0000000
reactant: MODEL1310110036#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
type: Reaction

metaM sphmyln hs c
initial concentration: 1.0
initial amount: NaN
name: sphingomyelin betaine
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:58216
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007

metaR DCYTDn
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
is: SBO:0000176
fast: false
reactant: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.5
is described by: ECO:0000254
name: deoxycytidine deaminase, nuclear
modifier: MODEL1310110036#
type: Reaction

metaR H2O2t
is: SBO:0000185
kinetic law: MODEL1310110036#
name: hydrogen peroxide transport via diffusion
is described by: ECO:0000000
reversible: true
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_15b5875f_a4d0_4ea6_bed1_6cf6efe89bb4
is: P42126
is encoded by: hsa:1632
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: ECI1
has only substance units: false
is: SBO:0000252

metaR r1374
reversible: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false
name: EC:3.2.1.14

metaR r0829
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.1.37
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
type: Reaction

metaR r2130
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
modifier: MODEL1310110036#

metaR LYStm
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: Lysine mitochondrial transport via ornithine carrier
fast: false
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

metaM nh4 n
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:28938
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
type: Species
name: ammonium
has only substance units: false

metaM CE2422 m
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: SBO:0000247
initial amount: NaN
is: HMDB11123
has only substance units: false
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110036#_d4a5a0ed_bddf_488f_893f_e71b5a2fa3a2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:171425
boundary condition: true
is: SBO:0000252
name: CLYBL
type: Species
constant: false
has only substance units: false

metaM adp n
has only substance units: false
is: SBO:0000247
is: CHEBI:456216
type: Species
is: HMDB01341
name: ADP(3-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_a58c08d7_2f9d_48d0_a167_b7792a159566
name: ACADVL
is: P49748
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:37
initial amount: NaN

metaM ala B e
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16958
type: Species
is: HMDB00056
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_6c24c378_49e5_4489_b053_327d68cf0633
is encoded by: hsa:11181
type: Species
is: O43280
initial amount: NaN
name: TREH
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaR r1616
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110036#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_dcc6c0ea_beba_4ae0_b924_776a92b61020
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: P21953
boundary condition: true
is encoded by: hsa:594
name: BCKDHB
constant: false

metaM hco3 c
constant: false
is: C00288
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
name: Bicarbonate
boundary condition: false
is: CHEBI:17544
has only substance units: false
is: HMDB00595
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_870d6e65_c15f_4f23_aa0c_610b25c766a0
is: P11498
boundary condition: true
is: SBO:0000252
name: PC
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5091
initial amount: NaN

metaR URIK1
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.48
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110036#
name: uridine kinase (ATP:Uridine)

metaM mal L m
boundary condition: false
name: (S)-malate(2-)
is: HMDB00156
type: Species
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15589

metaR r1262
is described by: ECO:0000000
reactant: MODEL1310110036#
product: MODEL1310110036#
name: EC:6.2.1.3
fast: false
kinetic law: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
is: SBO:0000176

metaM L2aadp m
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
initial amount: NaN
initial concentration: 1.0
name: L-2-aminoadipate(1-)
constant: false
is: HMDB00510
type: Species

metaR r1375
is: SBO:0000185
name: Transport reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
reactant: MODEL1310110036#
fast: false
type: Reaction
product: MODEL1310110036#
reversible: false
is described by: ECO:0000000

metaR XOL27OHtm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
name: 27 hydroxy cholesterol transport
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_eafdde4f_a324_494b_a880_f4006e59002f
name: SLC7A5
is: SBO:0000252
is: Q8IV97
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:8140

metaM adp m
constant: false
is: HMDB01341
has only substance units: false
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:456216
is: SBO:0000247
type: Species
is: C00008
boundary condition: false
name: ADP
initial amount: NaN
initial concentration: 1.0

metaR PPD2CSPp
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
name: PPD2CSPp
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
kinetic law: MODEL1310110036#

metaM tchola e
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0
is: SBO:0000247
name: taurocholic acid
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00036
constant: false
boundary condition: false

metaR r1619
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaR MECOAS1m
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
name: mesaconate--CoA ligase (GDP-forming)
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
reversible: true

metaR r1947
kinetic law: MODEL1310110036#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR DCK1n
type: Reaction
product: MODEL1310110036#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is: SBO:0000176
reactant: MODEL1310110036#
name: Deoxycytidine kinase, nuclear (ATP)
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: true

metaM fald c
is: SBO:0000247
name: formaldehyde
initial concentration: 1.0
is: CHEBI:16842
is: HMDB01426
boundary condition: false
initial amount: NaN
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
type: Species
has only substance units: false
constant: false

metaR r0464
is: SBO:0000176
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
reversible: true
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000

metaM hco3 e
is: SBO:0000247
name: Bicarbonate
constant: false
is: HMDB00595
has only substance units: false
is: CHEBI:17544
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: C00288
boundary condition: false

metaM adpcoa x
initial amount: NaN
is: C14143
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: adipoylcoa
type: Species
is: HMDB04047
notes: FORMULA: C27H39N7O19P3S CHARGE: -5

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

metaM CE0693 m
is: CHEBI:28387
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: 3-oxolaur-6-cis-enoyl-CoA
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
is: HMDB11123
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_65f35689_a274_4aea_906c_ceacca6d1e36
boundary condition: true
name: _T83654_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:T83654

http://identifiers.org/biomodels.db/MODEL1310110036#_4c0223e6_ffe3_4a30_af58_690e143cdac4
initial amount: NaN
is: Q96DU7
is: SBO:0000252
type: Species
boundary condition: true
name: ITPKC
initial concentration: NaN
constant: false
is encoded by: hsa:80271
has only substance units: false

metaR DNDPt34m
kinetic law: MODEL1310110036#
name: dGDP transport via dTDP antiport
modifier: MODEL1310110036#
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_7d7ff68a_c167_4815_9588_3af61b9c24da
initial concentration: NaN
is: P21912
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:6390
is: SBO:0000252
name: SDHB
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_7a293a36_bc16_40e7_8f4e_43dc8858a2fe
constant: false
type: Species
name: NDUFA9
boundary condition: true
is encoded by: hsa:4704
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q16795
initial amount: NaN

metaR r1618
modifier: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_0acf38f1_96d9_46fe_8962_ed37c5660cf2
constant: false
is: Q5JAM2
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:211
has only substance units: false
initial amount: NaN
name: ALAS1

metaM xol7ah3 c
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
constant: false
is: HMDB12455
initial concentration: 1.0
type: Species
is: CHEBI:28540
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r1167
reactant: MODEL1310110036#
reversible: false
type: Reaction
name: EC:2.3.1.26
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
is: SBO:0000176
fast: false

metaR r1624
product: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110036#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110036#

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
is: SBO:0000176
type: Reaction
modifier: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110036#

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_33d6e975_6053_4fc4_8db5_4fac6f319ad0
initial amount: NaN
name: _R33828_1_c
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:R33828
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_ce562e3f_5ee9_4bfa_a3c4_c1823df5c655
is: SBO:0000252
type: Species
initial amount: NaN
is: Q16836
has only substance units: false
initial concentration: NaN
name: HADH
boundary condition: true
constant: false
is encoded by: hsa:3033

metaM tdcoa c
constant: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: SBO:0000247
has only substance units: false
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
boundary condition: false
type: Species
is: HMDB01521
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57385

metaM Ssq23epx r
initial concentration: 1.0
is: CHEBI:15441
boundary condition: false
has only substance units: false
name: (S)-2,3-epoxysqualene
initial amount: NaN
is: HMDB01188
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054

metaR PFK
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.11
fast: false
reversible: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
name: phosphofructokinase
product: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_70d53741_51a0_4c47_bab4_c2a00df2d85c
initial amount: NaN
is encoded by: hsa:55512
name: SMPD3
is: Q9NY59
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR DHORD9
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.3.5.2
product: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
name: dihydoorotic acid dehydrogenase (quinone10)
type: Reaction
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_31b4b7f8_e3c4_426c_8e33_5795b7d8263c
initial concentration: NaN
name: NME1
has only substance units: false
is encoded by: hsa:4830
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_5c0f8273_d7a2_47fc_bb25_e18694320475
is: Q308M7
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:5169
is: SBO:0000252
type: Species
initial concentration: NaN
name: ENPP3

metaR GALt4
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
type: Reaction
reversible: true
name: galactose transport via sodium symport
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD

metaM dcacoa x
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: Decanoyl-CoA (n-C10:0CoA)
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
boundary condition: false
initial concentration: 1.0
is: HMDB06404
is: CHEBI:61430
has only substance units: false

metaM nac c
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00253
is: CHEBI:0
name: Nicotinate
is: HMDB01488
type: Species
constant: false
has only substance units: false
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_4a4a0ce7_a544_431e_8262_b73e3af1ec1f
type: Species
initial concentration: NaN
name: PIK3R2
boundary condition: true
initial amount: NaN
constant: false
is: O00459
is encoded by: hsa:5296
has only substance units: false
is: SBO:0000252

metaM ac m
initial amount: NaN
initial concentration: 1.0
is: HMDB00042
name: acetate
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
boundary condition: false

metaR r1625
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110036#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#
reversible: true

metaM ddcacoa x
is: CHEBI:57375
is: HMDB03571
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C01832
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_d4d7cb30_14b7_446a_8143_588101b010df
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:353
initial concentration: NaN
is: SBO:0000252
name: APRT
initial amount: NaN
constant: false
is: P07741

http://identifiers.org/biomodels.db/MODEL1310110036#_14bd1697_e9ea_4961_a9ad_a89a0d23e353
is encoded by: hsa:5232
name: PGK2
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: P07205

metaM adprbp e
is: HMDB06336
constant: false
type: Species
is: CHEBI:58673
initial concentration: 1.0
name: ADP-D-ribose 2'-phosphate(4-)
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H20N5O17P3 CHARGE: -4 INCHI: InChI=1S/C15H24N5O17P3/c16-12-7-13(18-3-17-12)20(4-19-7)14-11(35-38(25,26)27)9(23)6(33-14)2-32-39(28,29)37-40(30,31)36-15-10(24)8(22)5(1-21)34-15/h3-6,8-11,14-15,21-24H,1-2H2,(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/p-4/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C03246
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_488adb8a_6645_436e_87f6_c6c97da11fd6
has only substance units: false
is encoded by: hsa:AD000092
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _AD000092_1_c
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_602a0cb8_5a0e_4dfd_80f0_0440caa92963
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: GCDH
constant: false
has only substance units: false
is encoded by: hsa:2639

http://identifiers.org/biomodels.db/MODEL1310110036#_91f0de21_3284_4b54_9e5b_89ce7b4e2203
is: Q9UHI7
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: SLC23A1
type: Species
is encoded by: hsa:9963
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f50abcb6_007c_4d28_86f0_e28cd93ca00e
is: SBO:0000252
is encoded by: hsa:4846
constant: false
is: A0S0A7
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: NOS3
initial amount: NaN

metaM gua c
initial amount: NaN
constant: false
is: C00242
is: HMDB00132
is: SBO:0000247
name: Guanine
initial concentration: 1.0
is: CHEBI:16235
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
has only substance units: false
type: Species
boundary condition: false

metaM udpglcur r
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00935
initial amount: NaN
constant: false
is: CHEBI:58052
name: UDP-D-glucuronate
has only substance units: false
is: C00167
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167

metaR r1626
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#
is: SBO:0000185
reversible: true
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ala B c
is: HMDB00056
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:16958
constant: false
is: SBO:0000247
name: beta-alanine
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaR G5SDym
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: glutamate-5-semialdehyde dehydrogenase (m)
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.2.1.41
reversible: false
fast: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_4c6fddfb_2400_4dcb_bfff_dc0a00e09f8f
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:D87002
boundary condition: true
name: _D87002_1_m

http://identifiers.org/biomodels.db/MODEL1310110036#_16529116_a695_4906_ad06_ab1a07fc2b7c
constant: false
name: _AA177072_1_x
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AA177072
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaR PROt2r
reversible: true
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110036#
name: L-proline reversible transport via proton symport
modifier: MODEL1310110036#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR r0139
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
modifier: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_1190b741_d66d_469f_ba2c_0d77bf4945ca
is encoded by: hsa:30
initial amount: NaN
boundary condition: true
type: Species
is: Q96CA6
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: ACAA1

metaR ARAB Lt
reversible: true
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
name: L-arabinoase extracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
type: Reaction

metaR OMPDC
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.4.2.10
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
reversible: false
name: orotidine-5'-phosphate decarboxylase
product: MODEL1310110036#
is: SBO:0000176

metaM b2coa m
initial concentration: 1.0
constant: false
is: CHEBI:57332
initial amount: NaN
is: HMDB02009
type: Species
boundary condition: false
has only substance units: false
name: crotonoyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877

metaR TRPt
name: L-tryptophan transport
type: Reaction
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reactant: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
fast: false
is described by: ECO:0000269
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185

metaR r0340
fast: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is: SBO:0000176
product: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_07431321_e782_4db9_a242_0dd85d3916bf
name: PRDX2
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7001
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaM arachdcrn c
type: Species
is: CHEBI:57387
has only substance units: false
constant: false
is: HMDB01322
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial concentration: 1.0
name: C20:4 carnitine
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_d482882b_2212_43c4_bd4c_846c335446ca
is: E9PAK4
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:200010
boundary condition: true
name: SLC5A9

metaR r1627
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
reversible: true

metaM trdrd c
is: SBO:0000247
initial concentration: 1.0
name: Reduced thioredoxin
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: C00342
constant: false
is: CHEBI:15967

metaM thbpt4acam c
is: HMDB02281
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
boundary condition: false
initial concentration: 1.0
constant: false
name: 4a-hydroxytetrahydrobiopterin
type: Species
has only substance units: false
is: CHEBI:15374
initial amount: NaN
is: SBO:0000247

metaR GTHP
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
reversible: true
is described by: ECO:0000134
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.12
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.11.1.15
is version of: http://identifiers.org/ec-code/1.11.1.9
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_042f9584_6c1e_47ce_a35f_a56d3154f70e
type: Species
initial concentration: NaN
is encoded by: hsa:BC005314
initial amount: NaN
name: _BC005314_1_x
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_d1e96f93_5c91_4e44_9b65_7c35965198ff
boundary condition: true
name: PIK3CG
type: Species
is: P48736
is encoded by: hsa:5294
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR HMGCOARc
fast: false
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
kinetic law: MODEL1310110036#
is described by: ECO:0000134
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
reversible: false
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#

metaM 5aizc c
boundary condition: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: CHEBI:58564
has only substance units: false
is: C04751
initial concentration: 1.0
is: HMDB06273
type: Species
initial amount: NaN

metaR r1690
name: Y+LAT2 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#

metaM gua e
is: CHEBI:16235
type: Species
name: guanine
initial amount: NaN
boundary condition: false
is: HMDB00132
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_ea0848fc_305c_4171_aba2_dc62196b5bee
has only substance units: false
boundary condition: true
constant: false
name: _AI631997_1_m
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI631997
type: Species

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_803fd1af_727e_4498_8d1e_4a1ef988dee7
is encoded by: hsa:1607
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: DGKB
is: SBO:0000252
constant: false
type: Species

metaR ALAR
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000212
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
name: alanine racemase
is: SBO:0000176
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_b555ae15_fc48_4d75_b7da_3731b813e32c
type: Species
boundary condition: true
is encoded by: hsa:4645
name: MYO5B
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9H6Y6
has only substance units: false

metaR SBT Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
type: Reaction
name: D-sorbitol transport, extracellular
is: SBO:0000185
reactant: MODEL1310110036#

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110036#
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
reactant: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction

metaR FOLR2
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000254
name: folate reductase
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_38bf22aa_f898_4f06_9ffb_712a2f9c9409
is encoded by: hsa:211
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: P13196
boundary condition: true
name: ALAS1
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_605eaee0_cbf5_4663_9dbe_a65868d2124e
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:4720
constant: false
is: SBO:0000252
boundary condition: true
name: NDUFS2
is: B7Z792

metaR r1620
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
modifier: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM etoh c
name: ethanol
initial concentration: 1.0
is: HMDB00108
type: Species
constant: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16236
initial amount: NaN

metaM amp x
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
name: AMP
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: C00020
boundary condition: false
is: CHEBI:456215
is: SBO:0000247
is: HMDB00045

http://identifiers.org/biomodels.db/MODEL1310110036#_f75ecc65_c0dd_4d68_8575_53ff83e46ab0
is encoded by: hsa:AI373818
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: _AI373818_1_m

metaR ARACHDt2
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110036#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_c9265490_1945_48a6_a291_b4f0dc234827
name: _206_1_c
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:206

metaR SMPD3g
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
is described by: ECO:0000304
reversible: false
fast: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.12
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_c9ea4426_b17a_491f_a633_a4ded9efa353
has only substance units: false
name: TRNT1
constant: false
is encoded by: hsa:51095
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q96Q11
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_541b5453_18c4_4ca9_a785_2cd4f37ccc56
boundary condition: true
is encoded by: hsa:10449
is: SBO:0000252
type: Species
name: ACAA2
has only substance units: false
constant: false
initial concentration: NaN
is: P42765
initial amount: NaN

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR BILIRUBt2
fast: false
modifier: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110036#
name: bilirubin transport via bicarbonate countertransport
type: Reaction
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ

metaR GTHPe
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110036#
name: glutathione peroxidase (e)
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.11.1.9
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110036#_1ac65dba_cf3d_4bce_81c5_bf64cd5ec275
constant: false
boundary condition: true
initial concentration: NaN
name: _AI469183_1_x
is encoded by: hsa:AI469183
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM glx x
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
is: HMDB00119
initial amount: NaN
name: glyoxylate
boundary condition: false
is: SBO:0000247
is: CHEBI:36655
type: Species
initial concentration: 1.0

metaM 2mbcoa m
is: HMDB01041
constant: false
boundary condition: false
has only substance units: false
name: 2-methylbutanoyl-CoA(4-)
type: Species
initial concentration: 1.0
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: SBO:0000247
initial amount: NaN

metaM hexdicoa x
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB04047
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
name: hexadecanedioylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C14143

http://identifiers.org/biomodels.db/MODEL1310110036#_537629a0_468e_4ff4_b02c_68fc231ad389
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P30838
constant: false
name: ALDH3A1
type: Species
has only substance units: false
is encoded by: hsa:218
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_88b35395_f762_4950_84ad_1c74a57053aa
has only substance units: false
name: IDI1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3422
is: Q13907
type: Species
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_24e7f1f2_8941_438f_a770_b95aef5fd4c4
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: SLC26A7
is encoded by: hsa:115111
is: Q8TE54
is: SBO:0000252
initial amount: NaN

metaM ha pre1 l
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:16126
has only substance units: false
is: SBO:0000247
name: hyaluronan biosynthesis, precursor 1
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
constant: false
type: Species

metaR r1621
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#

metaR H2Oter
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reversible: true
name: H2O endoplasmic reticulum transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110036#

metaM srtn e
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
has only substance units: false
is: HMDB00259
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

metaR OXAtp
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110036#
name: oxalate transport out of peroxisome
reversible: false

metaR DCSPTN1t
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110036#
reversible: true
fast: false
is: SBO:0000185

metaM 5adtststerone c
type: Species
is: HMDB02961
is: CHEBI:16330
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false

metaR ETOHt
kinetic law: MODEL1310110036#
reversible: true
fast: false
is described by: ECO:0000000
name: ethanol reversible transport
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD

metaM 4abutn c
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01080
name: 4-Aminobutanal
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
is: C00555
is: CHEBI:58264
initial amount: NaN
boundary condition: false

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM dtdp c
name: dTDP
has only substance units: false
is: CHEBI:58369
initial amount: NaN
type: Species
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00363

metaM pro L c
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00162
is: CHEBI:17203
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_4cf41a0c_ce84_4d6d_8e2b_1d9c663a4ce4
initial amount: NaN
name: BAAT
is: Q14032
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:570
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_704751d1_30c7_4248_993a_41a97163ab20
is: P30084
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: ECHS1
is encoded by: hsa:1892

metaM 34dhoxmand m
type: Species
boundary condition: false
constant: false
is: CHEBI:27637
is: SBO:0000247
is: HMDB01866
initial amount: NaN
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
has only substance units: false
initial concentration: 1.0
name: 3,4-Dihydroxymandelate

metaM xoltetrol c
type: Species
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
initial concentration: 1.0
is: HMDB01231
is: CHEBI:17278
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false

metaR r1622
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110036#
product: MODEL1310110036#
fast: false
type: Reaction
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_bed1190a_fba0_4425_b10e_6a7eefb20cf7
initial amount: NaN
constant: false
is: SBO:0000252
is: B2RDZ2
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:55312
has only substance units: false
name: RFK

metaR 4HPRO LTte
reversible: true
fast: false
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: Transport of trans-4-hydroxy-L-proline

metaM etoh e
is: SBO:0000247
initial concentration: 1.0
name: ethanol
has only substance units: false
boundary condition: false
is: HMDB00108
initial amount: NaN
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
type: Species
is: CHEBI:16236
constant: false

metaM f1p c
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:18105
name: D-Fructose 1-phosphate
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
is: C01094
boundary condition: false
is: HMDB01076
has only substance units: false
initial amount: NaN

metaR CHATn
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
product: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.6
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
name: Choline O-acetyltransferase
fast: false
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_db937b51_00a4_45b3_ac9a_92a2b01343e3
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: ENTPD1
constant: false
is encoded by: hsa:953
is: Q86VV3
has only substance units: false
initial concentration: NaN

metaR SARCStm
is: SBO:0000185
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
type: Reaction
kinetic law: MODEL1310110036#
name: Sarcosine transport (mitochondrial)
reversible: false
fast: false

metaR r1623
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_24389c92_c485_4f03_8f7d_f5dde8e3989e
boundary condition: true
initial amount: NaN
name: PKM2
is: SBO:0000252
is encoded by: hsa:5315
has only substance units: false
is: P14618
constant: false
type: Species
initial concentration: NaN

metaM HC02208 e
has only substance units: false
initial concentration: 1.0
name: prostaglandin-d1
initial amount: NaN
boundary condition: false
is: CHEBI:27696
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110036#_8d29f382_91a2_45fe_99af_a1789ba7d27a
is: SBO:0000252
name: FLAD1
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80308
initial amount: NaN

metaM retinal cis 9 c
is: HMDB01358
is: SBO:0000247
is: CHEBI:17898
boundary condition: false
constant: false
name: all-trans-retinal
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_5cc49212_9de7_4178_958e_b5a2d0669ae8
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AL048840
is: SBO:0000252
name: _AL048840_1_c
boundary condition: true
initial concentration: NaN

metaM srtn c
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:350546
name: serotonin(1+)
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0
is: HMDB00259
constant: false
boundary condition: false

metaR r1951
kinetic law: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
type: Reaction
reversible: false
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b8c14b3f_0b6a_4a48_af76_34a4cbd34f72
has only substance units: false
is encoded by: hsa:9962
type: Species
is: SBO:0000252
constant: false
is: Q9UGH3
name: SLC23A2
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR NDPK6m
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000254
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110036#

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR RPI
modifier: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: ribose-5-phosphate isomerase
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
is version of: http://identifiers.org/ec-code/5.3.1.6
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_f18aea04_e6b1_4ee6_b132_d9c4558b5e95
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: AHCYL1
is encoded by: hsa:10768

metaM HC02207 c
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27555
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
name: prostaglandin-c2

http://identifiers.org/biomodels.db/MODEL1310110036#_25e6bae1_6728_4560_b924_a26da26cfca3
is: SBO:0000252
type: Species
is: P27144
initial amount: NaN
name: AK4
initial concentration: NaN
is encoded by: hsa:205
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_c7a6ecb4_ac1f_4ddf_81c7_fe459f37909e
initial concentration: NaN
name: SLC17A3
is: O00476
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10786

metaR r1014
is: SBO:0000185
reversible: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
name: Postulated transport reaction
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
fast: false

metaR r2323
reversible: true
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110036#_71fed14a_014e_436a_8b34_d3356746e569
has only substance units: false
initial concentration: NaN
is: Q9UI40
constant: false
is: SBO:0000252
name: SLC24A2
boundary condition: true
type: Species
is encoded by: hsa:25769
initial amount: NaN

metaM pro L e
name: L-proline
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00162
boundary condition: false
is: CHEBI:17203
is: SBO:0000247

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaM xol7ah3 m
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: HMDB12455
boundary condition: false
constant: false
is: CHEBI:28540
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM dtdp e
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01274
is: CHEBI:58369
constant: false
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247
has only substance units: false

metaR DURItn
reversible: true
reactant: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is: SBO:0000185
name: deoxyuridine transport in nucleus

http://identifiers.org/biomodels.db/MODEL1310110036#_4cad86e8_a632_4f2b_9a92_41aee06e80a5
is encoded by: hsa:9123
name: SLC16A3
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O15427
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_ee88d410_e3b3_475a_b547_dfdc2e1d20ee
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: B4DK61
initial concentration: NaN
type: Species
name: ACOX1
is encoded by: hsa:51
is: SBO:0000252

metaM thbpt4acam n
is: HMDB02281
type: Species
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d9bb4652_f65d_45e1_888e_39ea6c9bacb6
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC26A11
is: Q86WA9
is: SBO:0000252
is encoded by: hsa:284129
has only substance units: false
constant: false

metaM i e
name: iodide
has only substance units: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: HMDB12238
is: CHEBI:16382
initial concentration: 1.0

metaR r2324
product: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110036#

metaM thbpt c
name: 5,6,7,8-tetrahydrobiopterin
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
initial concentration: 1.0
is: CHEBI:15372
is: HMDB00027
boundary condition: false

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM mi1p D c
has only substance units: false
is: SBO:0000247
is: HMDB02985
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial concentration: 1.0
is: CHEBI:58433
type: Species
boundary condition: false
name: 1D-myo-inositol 1-phosphate(2-)
initial amount: NaN

metaR FAOXC16080m
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110036#_704c9c70_46d5_46c1_920e_8e43d11f19d3
boundary condition: true
constant: false
is: SBO:0000252
is: O43678
name: NDUFA2
type: Species
is encoded by: hsa:4695
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_151d7b8a_818a_47ba_b3d1_82ec74d7c2eb
type: Species
name: GGT5
has only substance units: false
is: P36269
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:2687
initial amount: NaN
initial concentration: NaN

metaM amp m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
type: Species
is: HMDB00045
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: AMP(2-)
is: CHEBI:456215

http://identifiers.org/biomodels.db/MODEL1310110036#_768e42c2_71ec_42d3_b096_fa20755e6405
name: DGKD
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:8527
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR KHK2
is described by: ECO:0000269
name: ketohexokinase (D-xylulose)
reactant: MODEL1310110036#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
reversible: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.3

metaM adp x
name: ADP(3-)
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species
initial amount: NaN
is: CHEBI:456216
is: HMDB01341

metaR RBFK
kinetic law: MODEL1310110036#
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110036#
name: riboflavin kinase
is described by: ECO:0000269
modifier: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.26

metaM udp c
initial concentration: 1.0
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
has only substance units: false
is: C00015
boundary condition: false
is: SBO:0000247
is: CHEBI:58223
name: UDP
constant: false
initial amount: NaN

metaR ADSK
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.25
name: adenylyl-sulfate kinase
is described by: ECO:0000269
product: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000176
reversible: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:

metaR r2321
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f4985b40_1ae3_439a_b24b_7aa163acc6c8
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _PRO1933_1_m
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:PRO1933

http://identifiers.org/biomodels.db/MODEL1310110036#_50abba87_d30d_4374_bde1_18d706ccec7b
initial concentration: NaN
is encoded by: hsa:2747
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P49448
name: GLUD2
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_acefb84a_ec9a_4acc_8635_b5894ba61b52
has only substance units: false
is: A8K0T6
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55512
type: Species
initial concentration: NaN
name: SMPD3
constant: false
initial amount: NaN

metaM HC00460 c
boundary condition: false
is: CHEBI:58044
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 2,5-dihydroxybenzoate
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false
constant: false
initial amount: NaN

metaM hexdicoa r
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
is: C08260
initial concentration: 1.0
name: hexadecanedioylcoa
is: HMDB00672
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: SBO:0000247

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaR PROSTGH2t
product: MODEL1310110036#
is: SBO:0000185
fast: false
reversible: true
name: Prostaglandin H2 transport
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
kinetic law: MODEL1310110036#

metaR r0027
type: Reaction
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
modifier: MODEL1310110036#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_a3f0f66f_e5c8_4871_a088_b2acf7557fa7
initial concentration: NaN
constant: false
is encoded by: hsa:AA081045
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: _AA081045_1_e

metaR PI45P5Pn
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
is: SBO:0000176
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
type: Reaction

metaM CE2435 m
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
name: trans,cis-deca-2,4-dienoyl-CoA
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial concentration: 1.0
constant: false
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110036#_54908a4f_769d_4ace_83e9_fb280d7448fc
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: NDUFA1
is: Q6IBB5
initial concentration: NaN
is encoded by: hsa:4694
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_4a57e90c_bb6c_45f9_88ae_753a4199770f
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: ADH7
constant: false
is: P40394
is encoded by: hsa:131

metaR ARACHt
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110036#

metaR r0604
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is: SBO:0000176
modifier: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
fast: false
reversible: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#

metaR r2322
reactant: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction

metaM i c
is: HMDB12238
is: CHEBI:16382
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: iodide
has only substance units: false

metaR CHOLPtg
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: choline phosphate intracellular transport
kinetic law: MODEL1310110036#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
product: MODEL1310110036#
reactant: MODEL1310110036#

metaR G6Pter
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
product: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269
reactant: MODEL1310110036#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110036#_61a2e714_c8d9_4a08_93e0_5c97bd6b3afa
name: PLCD1
has only substance units: false
is encoded by: hsa:5333
is: P51178
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaR q10tm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110036#
name: transport of ubiquinone into mitochondria
reversible: true
product: MODEL1310110036#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000185

metaR C4STMO2r
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
name: C-4 methyl sterol oxidase
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.14.13.72
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_2dd2734f_e9ea_4140_b9a9_b4157163e2fa
name: SLC24A4
initial concentration: NaN
is encoded by: hsa:123041
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaR CEPTC
type: Reaction
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
name: choline phosphotransferase
is: SBO:0000176
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.8.2
fast: false

metaR RE1903R
type: Reaction
fast: false
product: MODEL1310110036#
reversible: true
name: RE1903
reactant: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_7cee7f2b_d23b_43cf_8a63_6c461fa4f607
is: SBO:0000252
name: SLC22A2
boundary condition: true
is encoded by: hsa:6582
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaR r0603
type: Reaction
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
product: MODEL1310110036#
fast: false
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.12
is: SBO:0000176
is described by: ECO:0000000

metaR r1010
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185
name: Postulated transport reaction
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110036#

metaM dgsn c
is: HMDB00085
is: CHEBI:17172
type: Species
has only substance units: false
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaR INSTt4
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
fast: false
name: inositol transport via sodium symport
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_01613362_0c96_46fe_a1a7_b641cdfc47f0
name: ODC1
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:4953
initial amount: NaN
is: P11926
initial concentration: NaN

metaM mag hs c
is: HMDB12130
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
type: Species
has only substance units: false
name: monoacylglycerol 2
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: CHEBI:16987

http://identifiers.org/biomodels.db/MODEL1310110036#_97132cbc_2c47_4b2b_afac_41102f55efa1
is encoded by: hsa:7263
boundary condition: true
is: Q16762
initial concentration: NaN
initial amount: NaN
constant: false
name: TST
is: SBO:0000252
type: Species
has only substance units: false

metaR RE0512M
modifier: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE0512
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
fast: false
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110036#_fef61660_2f7d_43d1_91bd_dd44b9745877
constant: false
is: Q9BY07
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:57835
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC4A5
type: Species

metaR r2119
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110036#

metaR GTHPm
name: glutathione peroxidase, mitochondria
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.11.1.12
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
modifier: MODEL1310110036#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaM mthgxl c
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
initial concentration: 1.0
name: methylglyoxal
is: HMDB01167
is: CHEBI:17158
boundary condition: false
type: Species

metaM 7dhchsterol r
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:17759
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
name: cholesta-5,7-dien-3beta-ol
constant: false

metaR VD3
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
product: MODEL1310110036#
name: Vitamin D3 formation
reversible: true
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000134
kinetic law: MODEL1310110036#

metaM pail345p hs c
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57836
boundary condition: false

metaR OAGD3tg
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
type: Reaction
is: SBO:0000185
name: oagd3 hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ

metaR r2059
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000

metaR r2320
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110036#
is: SBO:0000185
type: Reaction

metaM Rtotal3 e
initial concentration: 1.0
has only substance units: false
is: C00255
notes: FORMULA: CO2FULLR3 CHARGE: -1
type: Species
name: R total 3 position
is: SBO:0000247
is: HMDB00244
boundary condition: false
is: CHEBI:3554
constant: false
initial amount: NaN

metaM dcacoa m
is: HMDB06404
is: CHEBI:61430
is: SBO:0000247
is: C05274
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110036#_7d2fd5a3_e1fc_432a_bc46_794450bce808
boundary condition: true
name: STS
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:412
is: P08842
initial concentration: NaN
constant: false
initial amount: NaN

metaR CREATt4 2 r
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110036#
reactant: MODEL1310110036#
name: Creatine transport (sodium symport) (2:1)
fast: false
type: Reaction

metaR CEPTE
is version of: http://identifiers.org/ec-code/2.7.8.2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110036#
reversible: false
product: MODEL1310110036#
is: SBO:0000176
name: ethanolamine phosphotransferase
modifier: MODEL1310110036#
type: Reaction
fast: false
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_c08e81bc_daa0_4614_b7ab_beb65dff1391
is: SBO:0000252
is encoded by: hsa:27068
name: PPA2
is: Q9H2U2
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r1599
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
reversible: true

metaR P4508B13r
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110036#
reversible: false
type: Reaction
name: sterol 12-alpha-hydroxylase (nadh)
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.14.13.95
is: SBO:0000176
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
modifier: MODEL1310110036#

metaR PEt
product: MODEL1310110036#
is described by: ECO:0000000
name: phosphatidylethanolamine transport
reversible: true
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185

metaM HC02207 e
is: CHEBI:27555
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: prostaglandin-c2

http://identifiers.org/biomodels.db/MODEL1310110036#_0e3f8d57_795d_4c4a_b7f3_d9b6c8c30f5d
boundary condition: true
name: FDFT1
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P37268
constant: false
is encoded by: hsa:2222
initial amount: NaN

metaM amp r
is: HMDB00045
initial amount: NaN
is: CHEBI:456215
is: SBO:0000247
is: C00020
name: AMP
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
has only substance units: false

metaR 34DHPLACOX NADP
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
is: SBO:0000176
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
reactant: MODEL1310110036#

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR ALCD2yf
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
is: SBO:0000176
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110036#
type: Reaction
fast: false
product: MODEL1310110036#
is described by: ECO:0000134

metaM lnlccoa c
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
name: linoleic coenzyme A
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01064
has only substance units: false
boundary condition: false
type: Species

metaR r0570
reversible: true
is version of: http://identifiers.org/ec-code/6.3.3.2
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
product: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_a4734b2b_7f20_4b68_9b17_f2a58b747dc5
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110036#_d00f95ee_046a_423a_994b_97cdddc49cb4
boundary condition: true
is: Q9UF12
type: Species
initial concentration: NaN
is encoded by: hsa:58510
initial amount: NaN
constant: false
is: SBO:0000252
name: PRODH2
has only substance units: false

metaM HC01118 r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57310
constant: false
type: Species
is: SBO:0000247
name: presqualene diphosphate(3-)
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
has only substance units: false

metaR OAGD3te
is: SBO:0000185
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
name: oagd3 hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110036#
reversible: true
type: Reaction

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaM dhlam m
is: HMDB00985
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:17694
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
name: dihydrolipoamide
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_ae09e0c8_b334_4ffc_8dc8_640c819690a8
initial concentration: NaN
is: A6NN98
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8898
type: Species
name: MTMR2
has only substance units: false
boundary condition: true

metaR r1013
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
name: Transport reaction
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
fast: false
reactant: MODEL1310110036#

metaR r0549
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110036#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.6.99.3
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/6.1.1.17
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
reactant: MODEL1310110036#

metaM ppi c
is: CHEBI:0
initial amount: NaN
is: SBO:0000247
type: Species
name: Diphosphate
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3
constant: false
has only substance units: false
is: HMDB00250
is: C00013
initial concentration: 1.0

metaM 3ohdcoa m
type: Species
boundary condition: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial concentration: 1.0
has only substance units: false
is: HMDB06402
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57349
name: 3-oxopalmitoyl-CoA(4-)

metaM dhlpro m
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:16194
initial concentration: 1.0
name: Dihydrolipolprotein
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
constant: false
boundary condition: false

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR FAOXC10C8x
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM arachdcoa c
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57368
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaM gdp c
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
has only substance units: false
is: HMDB01201
is: C00035
is: CHEBI:58189
name: GDP
initial concentration: 1.0
initial amount: NaN

metaR INSTt2r
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: inositol transport in via proton symport
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reactant: MODEL1310110036#
type: Reaction

metaM mescoa m
constant: false
type: Species
is: SBO:0000247
boundary condition: false
name: Mesaconyl-CoA
initial amount: NaN
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
has only substance units: false
is: CHEBI:27969
initial concentration: 1.0
is: C06028

metaM 3oddcoa m
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937
is: CHEBI:27868
constant: false

metaR DADAe
name: Deoxyadenosine deaminase, extracellular
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
type: Reaction
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
fast: false
modifier: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000176

metaM sT antigen g
has only substance units: false
name: sialyl-T antigen
notes: FORMULA: C25H40N2O18X CHARGE: -1
boundary condition: false
is: CHEBI:16565
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_c679f7aa_898f_451b_be8d_740f1a259646
is: E7ET32
initial concentration: NaN
is encoded by: hsa:2592
name: GALT
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaM dcdp m
initial concentration: 1.0
initial amount: NaN
name: dCDP(3-)
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58593
boundary condition: false
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_12a9293d_a672_4407_a9c7_2cfc12d7c6ac
type: Species
name: ACAT2
constant: false
is encoded by: hsa:39
is: Q9BWD1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR CO2tm
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
type: Reaction
product: MODEL1310110036#
name: CO2 transport (diffusion), mitochondrial
is: SBO:0000185
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000

metaM occoa c
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57386
is: HMDB01070
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

metaR ADAe
reversible: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
modifier: MODEL1310110036#
reactant: MODEL1310110036#
name: Adenosine deaminase, extracellular
product: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4

metaR r1052
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Vesicular transport
product: MODEL1310110036#
reversible: false
type: Reaction

metaM nad r
name: NAD(1-)
has only substance units: false
is: HMDB00902
constant: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57540
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_0ff57633_9169_4ae4_bff3_3c5db67007cb
is encoded by: hsa:10449
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ACAA2
is: P42765
has only substance units: false

metaR FAOXC2252053m
type: Reaction
kinetic law: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
reversible: false

metaM ddcacoa m
is: C01832
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: CHEBI:57375
type: Species
has only substance units: false
is: HMDB03571
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0

metaR r1853
product: MODEL1310110036#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false

metaM ppi e
type: Species
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
is: CHEBI:33019
boundary condition: false
is: HMDB00250
is: C00013
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_50b5dbe8_ee55_4835_9269_015b843f2959
initial concentration: NaN
is encoded by: hsa:4598
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: B2RDU6
name: MVK
boundary condition: true
constant: false
type: Species

metaM c12dccoa x
has only substance units: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: SBO:0000247
boundary condition: false
is: C14143
initial concentration: 1.0
name: dodecanedioylcoa
constant: false
is: HMDB04047
type: Species
initial amount: NaN

metaR r1628
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM HC00718 c
name: N-methylethanolaminium phosphate(1-)
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57781
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR r0547
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
reversible: true

metaM for e
constant: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: formate
initial concentration: 1.0
boundary condition: false
is: CHEBI:15740
is: HMDB00142
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR r1051
reversible: true
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_ad9b0748_f4a7_4515_9e7b_1305c2d53763
is: B2ZGL7
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:11343
name: MGLL
constant: false
initial concentration: NaN

metaR CERT1rt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
fast: false
name: ceramide transport protein
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
type: Reaction
is described by: ECO:0000304

metaR ASNNm
modifier: MODEL1310110036#
is described by: ECO:0000254
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.1
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
reversible: false
name: L-asparaginase (mitochondrial)
reactant: MODEL1310110036#
product: MODEL1310110036#

metaR PGI
product: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.9
modifier: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
name: glucose-6-phosphate isomerase
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_cd01d4a9_5bf5_42e3_8ccf_646358f0b532
constant: false
name: ALDH3A2
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:224
is: P51648
is: SBO:0000252

metaR RE2999M
type: Reaction
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE2999
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176

metaR r1850
modifier: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
product: MODEL1310110036#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f39ef298_8d81_466d_a3d0_4cea95824088
constant: false
initial concentration: NaN
is encoded by: hsa:3295
name: HSD17B4
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: E9PB82
type: Species
boundary condition: true

metaM gdp e
is: CHEBI:58189
has only substance units: false
is: SBO:0000247
is: HMDB01201
type: Species
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM ocdcea l
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:30823
has only substance units: false
is: SBO:0000247
name: oleate
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712

http://identifiers.org/biomodels.db/MODEL1310110036#_65793189_5ac8_45cd_9905_644655435343
has only substance units: false
is: P04745
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: AMY1C
type: Species
is encoded by: hsa:278
constant: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR r1913
type: Reaction
fast: false
product: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaR r1629
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_19288525_a9b8_44d8_9ce4_2725bff11b0f
is: F6KD01
is encoded by: hsa:5728
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: PTEN

metaR r1050
kinetic law: MODEL1310110036#
type: Reaction
name: Vesicular transport
reactant: MODEL1310110036#
fast: false
reversible: true
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
is: SBO:0000185

metaM CE1926 e
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: HMDB00127
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false
name: gama-carboxyethyl-hydroxychroman
type: Species
is: SBO:0000247
constant: false

metaR MECOALm
is described by: ECO:0000212
modifier: MODEL1310110036#
reversible: true
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110036#
fast: false
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
is version of: http://identifiers.org/ec-code/6.2.1.5

metaR ACCOAtn
is described by: ECO:0000000
kinetic law: MODEL1310110036#
name: acetyl-CoA transport, nuclear
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_6dbe5008_cd2c_4aa6_a599_20f7e85f364f
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:10587
name: TXNRD2

metaR RETFA
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110036#
name: retinol acyltransferase
fast: false
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110036#
is described by: ECO:0000000

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR 34DHPLACOX
modifier: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase

metaR ARACHDCOAtx
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reversible: true
name: fatty acid intracellular transport
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000

metaM methf m
name: (6R)-5,10-methenyltetrahydrofolate
boundary condition: false
constant: false
has only substance units: false
is: HMDB01354
is: SBO:0000247
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57455

metaR LNLNCAt
reversible: true
product: MODEL1310110036#
name: fatty acid transport via diffusion
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000

metaR PETOHMr hs
type: Reaction
modifier: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
is version of: http://identifiers.org/ec-code/2.1.1.17
name: phosphatidylethanolamine N-methyltransferase
reversible: false
is described by: ECO:0000254
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false

metaM acetone m
type: Species
initial concentration: 1.0
is: HMDB01659
name: acetone
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
boundary condition: false
is: CHEBI:15347
initial amount: NaN

metaR r0545
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM triodthy c
initial amount: NaN
is: HMDB00265
is: SBO:0000247
type: Species
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:18258

http://identifiers.org/biomodels.db/MODEL1310110036#_a34a62a6_ae6a_4117_9ad5_e53cfff2b8d3
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: DPYS
is encoded by: hsa:1807
is: Q14117
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR NTD11
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110036#
name: 5'-nucleotidase (IMP)
is described by: ECO:0000269
fast: false
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction

metaR HXPRT
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is: SBO:0000176
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000269
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110036#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
reversible: false
fast: false

metaM omhpal r
boundary condition: false
constant: false
initial amount: NaN
is: HMDB06294
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: w-hydroxypalmiticacid
type: Species
notes: FORMULA: C16H30O3 CHARGE: -1

metaR HDCAtr
product: MODEL1310110036#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110036#
reversible: true
name: fatty acid transport via diffusion

metaR r1117
is described by: ECO:0000000
fast: false
product: MODEL1310110036#
name: Facilitated diffusion
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
kinetic law: MODEL1310110036#

metaM pail45p hs n
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
is: CHEBI:28910
type: Species
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaR BDHm
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
type: Reaction
is: SBO:0000176
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.30
fast: false
product: MODEL1310110036#
is described by: ECO:0000269

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_ec0c7821_989d_403a_aba7_76e900654a97
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54995
type: Species
constant: false
is: Q9NWU1
name: OXSM
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM sgalside hs l
constant: false
is: CHEBI:16349
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
type: Species
initial concentration: 1.0
is: SBO:0000247
name: sulfatide galactocerebroside
is: HMDB00904
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_776f78cf_2210_433b_83b2_f0f7f496ab25
is: SBO:0000252
is: P22413
has only substance units: false
name: ENPP1
is encoded by: hsa:5167
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_fee22816_290a_4e5e_a9c6_f01df43f26ab
is encoded by: hsa:65985
initial concentration: NaN
name: AACS
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: Q86V21

http://identifiers.org/biomodels.db/MODEL1310110036#_db799807_f857_4fcf_ba2c_2f1b92af3802
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:1103
name: CHAT
is: SBO:0000252
has only substance units: false
is: P28329

http://identifiers.org/biomodels.db/MODEL1310110036#_5f4e4610_4ed3_4c6f_bd67_5b9ff5b13692
has only substance units: false
boundary condition: true
type: Species
is: A0PJK1
name: SLC5A10
constant: false
initial amount: NaN
is encoded by: hsa:125206
is: SBO:0000252
initial concentration: NaN

metaM icit c
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial amount: NaN
name: Isocitrate
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:16087
type: Species
is: HMDB00193
is: C00311
constant: false
initial concentration: 1.0

metaM HC02202 e
is: CHEBI:57398
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: prostaglandin A1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685

metaR 3MOX4HOXPGALDOX
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
type: Reaction
is: SBO:0000176
product: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
is described by: ECO:0000304
reversible: false

metaM g1p c
constant: false
boundary condition: false
is: HMDB01586
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
name: D-Glucose 1-phosphate
is: C00103
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:58601
has only substance units: false
initial concentration: 1.0

metaM arachd r
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: arachidonate
constant: false
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
initial amount: NaN
type: Species
boundary condition: false

metaR FAOXC160
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110036#
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000176

metaM ocdcea e
is: HMDB00207
notes: FORMULA: C18H33O2 CHARGE: -1
constant: false
type: Species
name: octadecenoate (n-C18:1)
initial concentration: 1.0
is: CHEBI:0
is: C00712
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM 3aib D c
initial amount: NaN
name: D-3-Amino-isobutanoate
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: C03265
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: HMDB02299

http://identifiers.org/biomodels.db/MODEL1310110036#_d459b4c5_1154_407e_9e52_4d06dc7e3064
initial concentration: NaN
is: Q9ULD0
constant: false
name: OGDHL
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55753
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_4bd0c6ef_35c0_487c_a993_3bddc7ee226f
is: Q9NQR4
type: Species
name: NIT2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:56954
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_782fc75a_e627_472d_a7a1_3590e4c0a0df
is encoded by: hsa:1718
type: Species
is: Q15392
constant: false
has only substance units: false
name: DHCR24
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM triodthy e
is: SBO:0000247
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00265
is: CHEBI:18258

metaM dcdp n
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: dCDP(3-)
is: SBO:0000247
is: CHEBI:58593
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial concentration: 1.0
type: Species
is: HMDB01245

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_f253bdc4_8b00_4b9d_88cf_85df797ce244
initial amount: NaN
type: Species
is encoded by: hsa:594
is: P21953
initial concentration: NaN
name: BCKDHB
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaR UMPK3n
is described by: ECO:0000269
name: UMP kinase (UTP),nuclear
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_23d1b677_ab61_4cc1_80f6_e380ace85fbd
initial concentration: NaN
boundary condition: true
is: Q8WUX1
name: SLC38A5
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:92745

metaM ppcoa m
is: CHEBI:57392
name: Propanoyl-CoA
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: C00100
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a274803e_c429_4185_be0b_1522c7c3365b
constant: false
is: F5H2Y9
initial amount: NaN
is encoded by: hsa:8854
name: ALDH1A2
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR ASPte
is: SBO:0000185
reversible: true
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
product: MODEL1310110036#
fast: false
is described by: ECO:0000134
name: diffusion of aspartate into blood
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_0dd7175b_4a25_44f0_8783_f421eddb946a
is: SBO:0000252
name: CPT2
is: P23786
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:1376
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_e77c61aa_11f6_4252_8dbe_cf58f1d5f73d
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI285872
name: _AI285872_1_c
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_18e1bf1e_c8b4_45cd_9bc8_96b83a9f7448
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P35575
type: Species
initial amount: NaN
is encoded by: hsa:2538
name: G6PC
has only substance units: false
constant: false

metaM 2mcit e
is: HMDB00379
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
type: Species
initial amount: NaN
is: CHEBI:15598
initial concentration: 1.0
constant: false
name: 2-methylcitrate(3-)
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_850ff95e_e10b_48e1_a0b8_b5230bde5cc1
constant: false
type: Species
name: NT5M
initial amount: NaN
has only substance units: false
is: Q9NPB1
is: SBO:0000252
is encoded by: hsa:56953
initial concentration: NaN
boundary condition: true

metaM pmtcoa c
is: HMDB01338
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
has only substance units: false
is: CHEBI:3454
is: C00154
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN

metaR r1116
reactant: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_dd9cfb66_d479_4cf4_af25_72833a99461f
boundary condition: true
constant: false
is: Q9Y345
is: SBO:0000252
name: SLC6A5
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9152
type: Species
has only substance units: false

metaR KCC2t
reactant: MODEL1310110036#
is described by: ECO:0000269
modifier: MODEL1310110036#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110036#
name: K+-Cl- cotransporter (NH4+)
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110036#_2ab9ad50_b658_4f85_8091_7f061e0c4752
boundary condition: true
name: GLUL
is: P15104
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:2752
is: SBO:0000252
constant: false
has only substance units: false

metaR DCSPTN1CRNt
fast: false
type: Reaction
is described by: ECO:0000269
reversible: false
name: transport into the mitochondria (carnitine)
is: SBO:0000185
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110036#_341c7db6_17cb_4da3_b0e6_b7aefc092630
is: SBO:0000252
initial amount: NaN
name: _AI694761_1_c
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:AI694761
boundary condition: true

metaM pail45p hs m
boundary condition: false
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate
constant: false
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM dgtp n
type: Species
initial amount: NaN
name: dGTP
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: C00286
is: HMDB01440
initial concentration: 1.0
is: CHEBI:16497
constant: false
has only substance units: false

metaM g1p e
has only substance units: false
constant: false
is: HMDB01586
name: alpha-D-glucose 1-phosphate(2-)
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: CHEBI:58601
initial concentration: 1.0

metaM HC02202 c
name: prostaglandin A1(1-)
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: CHEBI:57398

metaM hcys L c
is: SBO:0000247
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
initial concentration: 1.0
has only substance units: false
type: Species
name: L-homocysteine
is: HMDB00742
is: CHEBI:17588
boundary condition: false
constant: false
initial amount: NaN

metaM idp n
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
initial amount: NaN
boundary condition: false
is: HMDB03335
constant: false
name: IDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110036#_85bbfe31_719e_4123_a01a_ac4babf1f572
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: DLST
initial concentration: NaN
constant: false
is: SBO:0000252
is: P36957
is encoded by: hsa:1743

http://identifiers.org/biomodels.db/MODEL1310110036#_db2009a7_07f3_4d42_b238_857524c924cf
is: P32320
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:978
initial concentration: NaN
name: CDA
boundary condition: true

metaR THBPT4ACAMDASE
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_41a8a5ac_3c62_4f52_9507_de00e8483dae
is: P11166
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6513
constant: false
name: SLC2A1
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaR r1008
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
type: Reaction
is: SBO:0000185
product: MODEL1310110036#

metaM dcdp c
constant: false
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
is: HMDB01245
type: Species
initial amount: NaN
is: C00705
has only substance units: false
initial concentration: 1.0
name: dCDP
boundary condition: false

metaR r0541
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110036#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_bc6968fa_6c10_45d5_843e_8b789dff7eac
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: NT5C2
is: P49902
constant: false
is encoded by: hsa:22978
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_ed2865a0_7467_4610_96cb_c3d26a2d944b
constant: false
name: NDUFA12
is: F8VQS7
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:55967

http://identifiers.org/biomodels.db/MODEL1310110036#_88b6462e_511f_4581_9114_68f3366bee2d
constant: false
is encoded by: hsa:M68895
has only substance units: false
boundary condition: true
name: _M68895_1_c
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaM HC02206 e
boundary condition: false
name: prostaglandin C1(1-)
initial amount: NaN
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57399

metaR GHMT2rm
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.1.2.1
type: Reaction
reactant: MODEL1310110036#
reversible: true
name: glycine hydroxymethyltransferase, reversible, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110036#_c25d839d_ff13_4630_a48a_686cf2f34acd
initial amount: NaN
is encoded by: hsa:145226
constant: false
initial concentration: NaN
is: Q96NR8
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: RDH12

metaM methf c
is: C00445
initial concentration: 1.0
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57455
boundary condition: false
is: HMDB01354
name: 5,10-Methenyltetrahydrofolate

metaM coa x
is: HMDB01423
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57287
is: C00010
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Coenzyme A

metaM glcur r
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15748
initial concentration: 1.0
constant: false
name: D-glucuronate
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

metaR GUAt
reversible: true
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000269
name: Guanine transport
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reactant: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_1c10acb2_670f_4739_b071_c24ebc9361be
initial concentration: NaN
is encoded by: hsa:728637
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
name: _728637_1_c
initial amount: NaN

metaR CYTK6n
product: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110036#
name: cytidylate kinase (CMP,CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000269
fast: false
type: Reaction

metaR SO4HCOtex
fast: false
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: false
is described by: ECO:0000304
name: sulfate transport via bicarbonate countertransport
modifier: MODEL1310110036#
is: SBO:0000185

metaM CE2434 m
has only substance units: false
initial concentration: 1.0
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
type: Species
is: SBO:0000247
is: CHEBI:57795
constant: false
initial amount: NaN
boundary condition: false

metaR H2O2tp
reversible: true
name: hydrogen peroxide peroxisomal transport via diffusion
reactant: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
product: MODEL1310110036#
type: Reaction

metaR ORNt4m
fast: false
is described by: ECO:0000269
reactant: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: ornithine mitochondrial transport exchange with citruline
type: Reaction
modifier: MODEL1310110036#
reversible: true

metaR MI145PK
is version of: http://identifiers.org/ec-code/2.7.1.127
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
name: inositol-1,4,5-trisphosphate 3-kinase
is described by: ECO:0000269
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
is: SBO:0000176

metaM cmpacna c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:57812
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
boundary condition: false
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_ecb273f3_ab24_4cb0_bb94_c5d538dcaab6
is encoded by: hsa:285973
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q674R7
type: Species
name: ATG9B
constant: false
has only substance units: false

metaM mlthf c
is: HMDB01533
name: 5,10-Methylenetetrahydrofolate
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:15636
is: C00143
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN

metaR RE3218C
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.2
is: SBO:0000176
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
modifier: MODEL1310110036#
name: RE3218
product: MODEL1310110036#
type: Reaction

metaM xol7ah2 c
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
boundary condition: false
is: HMDB06893
name: 5beta-cholestane-3alpha,7alpha-diol
has only substance units: false
initial concentration: 1.0
is: CHEBI:28047
type: Species

metaM 2mcit c
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
initial concentration: 1.0
has only substance units: false
is: CHEBI:15598
boundary condition: false
type: Species
constant: false
name: 2-methylcitrate(3-)
is: SBO:0000247
initial amount: NaN
is: HMDB00379

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_07deb298_ccae_4714_9526_395ea60459bb
type: Species
is encoded by: hsa:2878
boundary condition: true
has only substance units: false
is: SBO:0000252
name: GPX3
initial concentration: NaN
is: P22352
constant: false
initial amount: NaN

metaR RE3568C
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
name: RE3568
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaM maltpt e
is: C02052
is: HMDB01296
name: maltopentaose
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141

metaM dcacoa c
is: SBO:0000247
is: HMDB06404
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
type: Species
initial amount: NaN
is: C05274

http://identifiers.org/biomodels.db/MODEL1310110036#_50677c68_b8a2_4288_a173_ee670ed4adfa
initial concentration: NaN
type: Species
name: PAH
constant: false
is: P00439
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5053
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_120b64e2_e9f9_48f4_80e6_ed93fbd64d69
type: Species
initial concentration: NaN
name: PLCXD2
is encoded by: hsa:257068
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: Q0VAA5

http://identifiers.org/biomodels.db/MODEL1310110036#_586a024c_80a4_4b6e_8746_6db92946910d
name: NDUFS6
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: Q6IBC4
type: Species
boundary condition: true
is encoded by: hsa:4726
initial concentration: NaN

metaM glu L m
name: L-glutamate(1-)
is: CHEBI:29985
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00148
constant: false
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_2412d894_e0cb_4d0b_ac51_7a8b0e90d254
is: O95479
has only substance units: false
initial amount: NaN
name: H6PD
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:9563

http://identifiers.org/biomodels.db/MODEL1310110036#_ba74dba0_1b5d_4e45_ac8b_426e8a4e9131
is encoded by: hsa:55350
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: VNN3
type: Species

metaR RTOTAL2t
reversible: true
is: SBO:0000185
reactant: MODEL1310110036#
name: RTOTAL2 transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
type: Reaction

metaR r0483
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is: SBO:0000176
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_90d2c73c_1f2d_4887_91bd_77b9e62381c2
is encoded by: hsa:219
boundary condition: true
is: SBO:0000252
is: P30837
constant: false
name: ALDH1B1
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_0a30b105_87ee_4e08_996c_2c751049b5b2
is: Q9NVF9
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:55224
has only substance units: false
type: Species
name: ETNK2

metaM g3p c
boundary condition: false
is: C00661
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial concentration: 1.0
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3930
name: Glyceraldehyde 3-phosphate
is: CHEBI:58027
initial amount: NaN
is: HMDB01112
has only substance units: false
type: Species

metaM 3oddcoa x
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 3-Oxododecanoyl-CoA
initial amount: NaN
is: CHEBI:27868
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
is: HMDB03937

metaM HC02206 c
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57399
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
has only substance units: false
name: prostaglandin C1(1-)
constant: false

metaM ocdcea c
is: SBO:0000247
constant: false
type: Species
is: CHEBI:0
initial amount: NaN
initial concentration: 1.0
is: HMDB00207
boundary condition: false
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
is: C00712

metaM HC00361 c
has only substance units: false
name: sedoheptulose 1,7-bisphosphate(4-)
initial concentration: 1.0
is: CHEBI:58335
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
constant: false

metaM idp c
initial amount: NaN
is: CHEBI:58280
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: IDP(3-)
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
is: HMDB03335

metaM cholcoar x
initial concentration: 1.0
is: HMDB02178
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:58677
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
constant: false

metaM ppi m
is: C00013
is: SBO:0000247
name: Diphosphate
is: CHEBI:33019
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
is: HMDB00250
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f8aecd9e_3c68_47d2_9c1e_bb63e848b2a2
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:6470
name: SHMT1
is: SBO:0000252
initial amount: NaN
type: Species

metaM fmn e
notes: FORMULA: C17H19N4O9P CHARGE: -2
is: CHEBI:58210
constant: false
initial concentration: 1.0
name: FMN
initial amount: NaN
is: C00061
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB01520
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_91322574_b81e_44df_b3d8_b9700bdd155e
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:22934
constant: false
initial concentration: NaN
is: P49247
name: RPIA
boundary condition: true

metaR MDHm
kinetic law: MODEL1310110036#
name: malate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.37
is: SBO:0000176
fast: false
is described by: ECO:0000134
reactant: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
product: MODEL1310110036#
reversible: true

metaM 3aib D e
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: C03265
type: Species
is: HMDB02299
name: D-3-Amino-isobutanoate
boundary condition: false

metaR ABTD
name: L-arabinitol 4-dehydrogenase
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_82e82636_be1b_466c_a92a_71b7fde2c228
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6715
is: P18405
name: SRD5A1
type: Species
has only substance units: false

metaM CE5101 m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
constant: false
is: CHEBI:57795
has only substance units: false

metaM mi134p c
is: CHEBI:58414
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: HMDB01143
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species

metaM pmtcrn c
is: HMDB00222
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17490
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
type: Species
boundary condition: false
name: L-palmitoylcarnitine
has only substance units: false

metaM nad x
is: CHEBI:57540
constant: false
is: C00003
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00902
boundary condition: false
name: Nicotinamide adenine dinucleotide

metaR r1007
kinetic law: MODEL1310110036#
fast: false
name: Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#

metaR DNDPt8m
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110036#
name: dADP transport via dUDP antiport
reversible: false
modifier: MODEL1310110036#
fast: false
is described by: ECO:0000269
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185

metaR NCCt
notes: GENE_ASSOCIATION: (6559.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739168,PMID:8528245,PMID:8670281,PMID:8812482 NOTES:NCD
type: Reaction
fast: false
is: SBO:0000185
name: Na+-Cl- cotransport
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: false
is described by: ECO:0000269

metaM pe hs r
name: phosphatidylethanolamine
boundary condition: false
is: CHEBI:16038
constant: false
has only substance units: false
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM taur e
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
name: Taurine
initial amount: NaN
is: HMDB00251
is: SBO:0000247
is: CHEBI:3544
notes: FORMULA: C2H7NO3S CHARGE: 0
is: C00245
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_22ad142b_03a6_46bb_b19a_099f5b28ef74
name: KYNU
boundary condition: true
is: Q16719
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8942
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaM ddcacoa c
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
is: CHEBI:57375
is: HMDB03571
is: C01832
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_e85ce25f_ebc9_4c7e_9d1e_490113f4e991
is: Q9NRR6
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:56623
boundary condition: true
name: INPP5E
has only substance units: false

metaM sgalside hs g
type: Species
boundary condition: false
is: HMDB00061
constant: false
has only substance units: false
is: CHEBI:58343
name: sulfatide galactocerebroside
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial concentration: 1.0
is: SBO:0000247

metaM itaccoa m
is: SBO:0000247
is: HMDB03377
has only substance units: false
constant: false
name: itaconyl-CoA(5-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: CHEBI:57381
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_fefaf5f7_da28_4f63_9802_8975db697f75
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: Q9ULC5
is: SBO:0000252
name: ACSL5
is encoded by: hsa:51703
initial amount: NaN
constant: false

metaM acetone e
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:15347
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
type: Species
has only substance units: false
boundary condition: false
is: HMDB01659
name: acetone

http://identifiers.org/biomodels.db/MODEL1310110036#_881e0c40_495e_4467_891d_6032199e5c4a
is: Q8WXF9
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: SLC2A11
initial concentration: NaN
is encoded by: hsa:66035

metaR EX cholate LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholate
type: Reaction

metaM tag hs e
is: SBO:0000247
name: triglyceride
is: CHEBI:17855
initial concentration: 1.0
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_98efe1d1_c1ec_4f67_b9db_85504b74b92a
name: ABCD1
initial concentration: NaN
is encoded by: hsa:215
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: P33897
is: SBO:0000252

metaM fmn c
name: FMN
is: C00061
boundary condition: false
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial concentration: 1.0
initial amount: NaN
is: HMDB01520
constant: false
is: CHEBI:58210
has only substance units: false
is: SBO:0000247

metaM retn r
initial concentration: 1.0
name: all-trans-retinoate
type: Species
is: CHEBI:35291
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false

metaM 3aib D m
name: D-3-Amino-isobutanoate
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
boundary condition: false
is: C03265
is: SBO:0000247
type: Species
is: HMDB02299
constant: false
initial amount: NaN
initial concentration: 1.0

metaM glcur l
is: HMDB00127
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:15748

metaM idp e
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
is: CHEBI:58280
boundary condition: false
is: SBO:0000247
name: IDP(3-)
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR UMPKn
product: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
kinetic law: MODEL1310110036#
is described by: ECO:0000269
reversible: true
fast: false
name: UMP kinase, nuclear
type: Reaction
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR URIDK2m
reactant: MODEL1310110036#
name: uridylate kinase (dUMP), mitochondrial
fast: false
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
is: SBO:0000176
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110036#_c14c1191_92ad_498b_8d04_55ddd6be41a1
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: FASN
is encoded by: hsa:2194
is: P49327
type: Species
initial concentration: NaN

metaR SPHMYLNtg
is described by: ECO:0000000
product: MODEL1310110036#
is: SBO:0000185
reversible: true
reactant: MODEL1310110036#
name: sphingomyelin intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
fast: false
type: Reaction
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_bb6a13e9_e3c7_4eb5_9eda_5b98e30281fd
name: GPX1
constant: false
is encoded by: hsa:2876
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM pail4p hs n
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
has only substance units: false
is: CHEBI:58178
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR HSD3A1r
reversible: true
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
reactant: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
kinetic law: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_6200f86b_5f97_464c_afa0_f5b3c43487b9
is: SBO:0000252
initial concentration: NaN
name: PANK1
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:53354

metaR CO2tp
is described by: ECO:0000000
product: MODEL1310110036#
reversible: true
fast: false
is: SBO:0000185
name: CO2 peroxisomal transport
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM ppcoa c
has only substance units: false
initial amount: NaN
is: C00100
name: Propanoyl-CoA
is: HMDB01275
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57392
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_5bd03d11_88a7_4958_9760_77cadfaf444a
name: ACADVL
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:37
has only substance units: false
type: Species
constant: false
is: P49748

metaR DM anth
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaR GLU5Km
reactant: MODEL1310110036#
is described by: ECO:0000254
name: glutamate 5-kinase (m)
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.41
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
type: Reaction
product: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000176

metaM ppa m
name: propionate
is: SBO:0000247
type: Species
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
is: CHEBI:17272
is: HMDB00237
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_6a86cff6_4c9e_4d25_9be2_6101aa263e7a
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: PLCD4
initial amount: NaN
is: Q9BRC7
boundary condition: true
is encoded by: hsa:84812

http://identifiers.org/biomodels.db/MODEL1310110036#_febfd38d_826c_45de_870b_db3db116e81c
initial concentration: NaN
is: Q9NY65
constant: false
is: SBO:0000252
is encoded by: hsa:1962
type: Species
name: EHHADH
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_8661c2c7_9a30_4e7f_9385_2a2b38d9e693
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: _AI378339_1_m
has only substance units: false
constant: false
is encoded by: hsa:AI378339
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_192e0bcd_16ac_4eb6_8995_92ce9b5cf600
is encoded by: hsa:377841
type: Species
name: ENTPD8
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: Q5MY95
is: SBO:0000252

metaR r0480
fast: false
is: SBO:0000176
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

metaR r1560
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR LACZe
product: MODEL1310110036#
name: b-galactosidase, extracellular
kinetic law: MODEL1310110036#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
is version of: http://identifiers.org/ec-code/3.2.1.108
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR UMPKm
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000134
fast: false
is: SBO:0000176
name: UMP kinase (mitochondrial, ATP)
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT

metaM ppi n
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
name: diphosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110036#_fa690859_a57b_4697_927f_cdaaa260bff5
is: E7EPT3
initial concentration: NaN
is encoded by: hsa:501
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: ALDH7A1
constant: false
is: SBO:0000252

metaR ITPtn
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
product: MODEL1310110036#
type: Reaction
fast: false
reversible: true
name: ITP nuclear transport
reactant: MODEL1310110036#
is described by: ECO:0000000

metaM taur c
is: C00245
type: Species
has only substance units: false
constant: false
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
is: HMDB00251
boundary condition: false
is: CHEBI:3544
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_c594c7d3_0a2e_44c1_84b2_91e5857fe0bf
is: SBO:0000252
initial amount: NaN
name: ACSL6
type: Species
is encoded by: hsa:23305
initial concentration: NaN
constant: false
is: B2RB13
boundary condition: true
has only substance units: false

metaR FACOAL2251
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110036#
fast: false
is: SBO:0000176
name: fatty-acid--CoA ligase
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction

metaM acetone c
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
type: Species
boundary condition: false
name: acetone
is: HMDB01659

http://identifiers.org/biomodels.db/MODEL1310110036#_e0fb3641_5b49_48f5_9273_eef304616bd4
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:622
name: BDH1
constant: false
boundary condition: true
initial concentration: NaN

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR r1561
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#

metaR FBA
reactant: MODEL1310110036#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is described by: ECO:0000134
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
name: fructose-bisphosphate aldolase
product: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_42dc0d4d_81a3_4bd2_900d_1035586fc594
boundary condition: true
name: ARSA
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P15289
is encoded by: hsa:410
type: Species
is: SBO:0000252
constant: false

metaR 4MOPt2im
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110036#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_40b31420_ae64_4899_8405_d846e2d29aff
is: Q8N1Q1
is encoded by: hsa:377677
type: Species
name: CA13
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_01441ec7_8a32_4891_bc55_b132d6461673
name: ATP2B4
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:493
constant: false
boundary condition: true
type: Species
is: P23634

metaM aacoa c
is: SBO:0000247
constant: false
has only substance units: false
name: Acetoacetyl-CoA
initial concentration: 1.0
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: C00332
is: CHEBI:57286
boundary condition: false
type: Species
initial amount: NaN

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_cd7e2fad_1c1f_4123_a49c_ba298fd079f3
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8396
is: SBO:0000252
name: PIP4K2B
boundary condition: true
is: P78356

http://identifiers.org/biomodels.db/MODEL1310110036#_53d27b92_d0fe_4740_82cd_52ff52bfcb03
is encoded by: hsa:AL050025
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: _AL050025_1_c
constant: false
has only substance units: false

metaR SUCCtp
name: succinate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#

metaR NADNe
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.2.5
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:
kinetic law: MODEL1310110036#
name: NAD nucleosidase,extracellular
modifier: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000269
reactant: MODEL1310110036#
is: SBO:0000176
reversible: false

metaR r0268
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
product: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110036#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
kinetic law: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2

metaM tag hs c
constant: false
is: SBO:0000247
type: Species
name: triglyceride
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: CHEBI:17855
has only substance units: false

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
reversible: true

metaM glyclt x
name: glycolate
constant: false
is: CHEBI:29805
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
type: Species
is: HMDB00115
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_a016017f_1b46_4a31_a5b4_e7d514925321
initial amount: NaN
boundary condition: true
is encoded by: hsa:AV713053
is: SBO:0000252
constant: false
type: Species
name: _AV713053_1_m
has only substance units: false
initial concentration: NaN

metaR ECOAH9m
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110036#
fast: false
is: SBO:0000176
modifier: MODEL1310110036#
product: MODEL1310110036#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
type: Reaction

metaM arachd l
is: CHEBI:32395
type: Species
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM cholcoar r
initial amount: NaN
type: Species
has only substance units: false
is: HMDB02178
constant: false
is: CHEBI:58677
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110036#_2598264e_3455_4e11_85f1_2ef81135102e
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2821
constant: false
is: P06744
boundary condition: true
has only substance units: false
name: GPI

http://identifiers.org/biomodels.db/MODEL1310110036#_12c78d1f_a2bf_4126_a07a_8ff794f66c4f
type: Species
constant: false
has only substance units: false
is encoded by: hsa:314
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: AOC2
initial concentration: NaN

metaR FADH2tru
reversible: false
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
name: FADH2 transporter, endoplasmic reticulum
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_5e8c58b7_7342_4912_bacb_b5a1c5c45b3d
boundary condition: true
initial concentration: NaN
constant: false
name: SLC22A2
type: Species
is: O15244
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:6582

metaM adrncoa c
is: C16170
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_055cc6ba_8d61_4fd9_9aed_3f99c7773d5d
name: PECR
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55825
has only substance units: false
is: Q9BY49
constant: false
type: Species

metaM sgalside hs c
constant: false
name: sulfatide galactocerebroside
boundary condition: false
is: HMDB03406
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:16523
type: Species

metaM ncam e
is: C00153
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:0
name: Nicotinamide
notes: FORMULA: C6H6N2O CHARGE: 0
boundary condition: false
constant: false
is: HMDB01406
is: SBO:0000247
initial concentration: 1.0

metaR NDPK3n
fast: false
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
reactant: MODEL1310110036#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000304
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM for r
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00142
type: Species
is: C00058
is: CHEBI:15740
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
name: Formate
initial amount: NaN

metaR PSSA1 hs
product: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
name: Phosphatidylserine synthase homo sapiens
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.29
modifier: MODEL1310110036#
is described by: ECO:0000269

metaR AMETr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110036#
name: S-Adenosyl-L-methionine intracellular diffusion
fast: false
type: Reaction
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000

metaR 3MOBte
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110036#
fast: false
name: Transport of 3-methyl-2-oxobutanoate
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110036#

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM 5mthf e
initial amount: NaN
is: HMDB01396
has only substance units: false
is: SBO:0000247
is: C00440
type: Species
name: 5-Methyltetrahydrofolate
boundary condition: false
initial concentration: 1.0
is: CHEBI:3729
notes: FORMULA: C20H24N7O6 CHARGE: -1
constant: false

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_f890659b_ccf8_4484_a0d5_d292f674a65d
initial concentration: NaN
name: ALPP
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:250
boundary condition: true
is: P05187
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_23009d2d_de32_4dda_a470_d29e108cdf64
is: SBO:0000252
is encoded by: hsa:217
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: P05091
initial concentration: NaN
name: ALDH2
boundary condition: true

metaR r2354
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM ppi r
type: Species
name: Diphosphate
is: CHEBI:33019
is: C00013
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00250
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

metaM glyc c
is: CHEBI:17754
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
name: Glycerol
boundary condition: false
is: HMDB00131
is: C00116
is: SBO:0000247
constant: false

metaM 4aphdob c
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58147
is: HMDB00978
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
has only substance units: false

metaM gal e
is: C00124
name: D-Galactose
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
is: HMDB00143
has only substance units: false
is: CHEBI:0
constant: false
is: SBO:0000247

metaR LEUTAm
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110036#
reversible: true
product: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110036#
name: leucine transaminase, mitochondrial
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110036#

metaR r1564
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_4628bd64_9792_41b9_9727_6bf7121af062
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: NDUFA11
is encoded by: hsa:126328
boundary condition: true
is: C9JT23
initial concentration: NaN
is: SBO:0000252

metaR RE1898C
reactant: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
name: RE1898
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reversible: true

metaR O2Stm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
name: superoxide anion transport via diffusion (mitochondria)
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_52219966_cd09_492c_84af_9e16121246c4
has only substance units: false
name: _AI934540_1_c
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI934540
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_473ab31d_b7c6_4b50_a02e_c75a9676b2aa
is: Q4W5N8
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:51166
initial concentration: NaN
has only substance units: false
name: AADAT
type: Species
constant: false

metaR r0683
fast: false
is: SBO:0000176
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:

metaM octa c
boundary condition: false
is: HMDB00482
type: Species
name: octanoate (n-C8:0)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:25646
is: SBO:0000247
is: C06423
notes: FORMULA: C8H15O2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110036#_5317a189_8248_4b06_9485_8f9afae696eb
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79717
constant: false
name: PPCS
is: Q9HAB8
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true

metaR CYTK14n
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaM strdnccoa m
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06519
constant: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205473
is: C16163
name: stearidonyl coenzyme A
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r2353
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM spmd c
has only substance units: false
initial concentration: 1.0
is: CHEBI:57834
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: C00315
is: SBO:0000247
constant: false
name: Spermidine
type: Species
is: HMDB01257
initial amount: NaN
boundary condition: false

metaM 3hmp m
name: 3-hydroxy-2-methylpropanoate
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:11805
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: HMDB00023
boundary condition: false

metaM dgtp c
is: CHEBI:16497
is: HMDB01440
is: C00286
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: dGTP
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaM ppcoa x
is: SBO:0000247
is: C00100
type: Species
is: CHEBI:57392
name: Propanoyl-CoA
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
is: HMDB01275

metaR r2000
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
fast: false
reversible: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#

metaR O2ter
kinetic law: MODEL1310110036#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110036#
product: MODEL1310110036#
name: O2 transport, endoplasmic reticulum
type: Reaction
is: SBO:0000185

metaR r1418
is: SBO:0000176
product: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
fast: false
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
reactant: MODEL1310110036#
reversible: true
is described by: ECO:0000000

metaM malcoa c
is: CHEBI:57384
has only substance units: false
is: HMDB01175
type: Species
boundary condition: false
constant: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: SBO:0000247
is: C00083
initial amount: NaN
name: Malonyl-CoA
initial concentration: 1.0

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR r1563
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_c237fc00_5b94_4f06_8899_49f582393fbd
type: Species
name: MTHFD2
constant: false
boundary condition: true
is: P13995
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10797
has only substance units: false
initial amount: NaN

metaM trp L e
boundary condition: false
is: CHEBI:16828
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
type: Species
name: L-tryptophan
has only substance units: false

metaR r2090
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0267
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
modifier: MODEL1310110036#
reactant: MODEL1310110036#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
reversible: true
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.9
fast: false

metaM frdp x
is: HMDB00961
initial amount: NaN
is: CHEBI:175763
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
name: farnesyl pyrophosphate(3-)
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaR r2092
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_e51f7f66_066f_4f9a_b938_2e5acfa307d6
has only substance units: false
is: SBO:0000252
name: _AU149534_1_c
initial concentration: NaN
is encoded by: hsa:AU149534
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaR r2356
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#

metaM gluside hs r
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: CHEBI:18368
has only substance units: false
boundary condition: false
type: Species
name: D-glucosyl-N-acylsphingosine
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_e0c708cc_0ddf_4678_880f_5867b6175a07
is: SBO:0000252
initial concentration: NaN
type: Species
name: MECR
initial amount: NaN
is encoded by: hsa:51102
has only substance units: false
constant: false
boundary condition: true
is: Q9BV79

http://identifiers.org/biomodels.db/MODEL1310110036#_12f5c2cc_0845_4daa_9a18_5b08cdb38bce
type: Species
is: Q02218
name: OGDH
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4967
boundary condition: true

metaM acetol c
is: CHEBI:27957
is: HMDB06961
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: hydroxyacetone
is: SBO:0000247
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_0e1b0fb1_3aa6_4290_bac5_169911bcd934
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI222095
is: SBO:0000252
name: _AI222095_1_m
has only substance units: false
type: Species

metaR ITCOALm
is described by: ECO:0000212
modifier: MODEL1310110036#
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176
reversible: true
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

metaR r1566
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
fast: false
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_603ba469_fcde_417f_b9cd_18d1900a74bf
name: PNPO
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55163
is: SBO:0000252
is: Q9NVS9
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_8440a285_f5cf_4cba_bd01_f553dd976af7
name: NMNAT3
is: Q96T66
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:349565
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_0b275d4e_e884_480e_84af_d11a40ce3b92
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: _AI024818_1_c
is encoded by: hsa:AI024818
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM gal c
name: D-Galactose
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
is: C00124
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:0
is: HMDB00143
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_1c279052_c62a_478c_b739_3b71359c607b
has only substance units: false
boundary condition: true
type: Species
is: Q96P26
initial amount: NaN
constant: false
is: SBO:0000252
name: NT5C1B
initial concentration: NaN
is encoded by: hsa:93034

metaR RE2069C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
name: RE2069
reactant: MODEL1310110036#
is: SBO:0000176
fast: false

metaM octa e
is: HMDB00482
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: octanoate (n-C8:0)
has only substance units: false
is: SBO:0000247
is: CHEBI:25646
is: C06423

metaR ASNtN1
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000269
name: Asparagine transport (Na, H coupled)
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110036#
reversible: true
product: MODEL1310110036#

metaM acgam l
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
is: HMDB00215
initial amount: NaN
type: Species
name: N-acetyl-D-glucosamine
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d9c4ab35_fed5_40eb_ab62_d643f41c9d9e
name: LTA4H
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P09960
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:4048

metaM homoval m
type: Species
initial concentration: 1.0
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
name: Homovanillate
initial amount: NaN
is: HMDB00118
constant: false
is: SBO:0000247
is: CHEBI:545959
has only substance units: false
boundary condition: false

metaR r2355
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#

metaM arachdcoa r
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
is: HMDB06523
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:57368
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

metaR r2093
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#

metaR SQLSr
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000134
name: Squalene synthase
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
is version of: http://identifiers.org/ec-code/2.5.1.21
fast: false
type: Reaction

metaR VLCSr
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
product: MODEL1310110036#
type: Reaction
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Very-long-chain-fatty-acid-CoA ligase
modifier: MODEL1310110036#

metaM ppa e
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: HMDB00237
initial amount: NaN
is: SBO:0000247
name: propionate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_df3f62ef_b4bc_4092_b497_867c7be81294
is: SBO:0000252
is encoded by: hsa:206358
type: Species
initial concentration: NaN
is: Q1LZ56
constant: false
boundary condition: true
name: SLC36A1
has only substance units: false
initial amount: NaN

metaM spmd e
is: HMDB01257
initial concentration: 1.0
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
boundary condition: false
is: C00315
is: CHEBI:57834
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f2bffe6b_8923_4bf2_9cd1_4eb30ba757e8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9H999
constant: false
type: Species
is encoded by: hsa:79646
has only substance units: false
name: PANK3
boundary condition: true

metaR r1565
fast: false
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaR r1499
is: SBO:0000185
reversible: false
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
fast: false
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1

http://identifiers.org/biomodels.db/MODEL1310110036#_b59863e8_2e05_4db2_81c8_9cfa432e39ea
name: GK
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: B4DH54
is: SBO:0000252
is encoded by: hsa:2710
type: Species
initial concentration: NaN

metaR XOLDIOLONEt
is: SBO:0000185
name: lipid, flip-flop intracellular transport
type: Reaction
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ

metaR LEUKTRD4t
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000269
name: leukotriene D4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
is: SBO:0000185
product: MODEL1310110036#

metaR r0680
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.137
type: Reaction
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110036#

metaR r0321
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.2
fast: false
reversible: false
modifier: MODEL1310110036#
product: MODEL1310110036#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
type: Reaction
is: SBO:0000176

metaM ribflv c
has only substance units: false
name: Riboflavin
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: SBO:0000247
is: C00255
is: HMDB00244
type: Species
constant: false
is: CHEBI:3554

metaR r1568
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true

metaM tdchola e
has only substance units: false
constant: false
is: HMDB00951
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:9407
initial concentration: 1.0
name: taurochenodeoxycholate

metaM pmtcrn r
has only substance units: false
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
constant: false
boundary condition: false
is: CHEBI:17490
name: L-palmitoylcarnitine
type: Species
initial amount: NaN
initial concentration: 1.0

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR r2358
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Organic anion transporter 5 Utilized transport
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_bb409789_2aa4_4d09_a90e_75b18467900a
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q8WUD6
is: SBO:0000252
name: CHPT1
is encoded by: hsa:56994
type: Species

metaM HC01401 x
constant: false
is: CHEBI:27668
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
boundary condition: false
initial concentration: 1.0
type: Species

metaR r0488
is: SBO:0000176
product: MODEL1310110036#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reversible: true
kinetic law: MODEL1310110036#
fast: false

metaR KYNAKGAT
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false
reversible: false
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
product: MODEL1310110036#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
name: L-Kynurenine:2-oxoglutarate aminotransferase

http://identifiers.org/biomodels.db/MODEL1310110036#_f3367a34_14ca_4eca_a069_72cfa5c68b2d
name: UPP2
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: O95045
is: SBO:0000252
is encoded by: hsa:151531
initial concentration: NaN

metaR r1631
type: Reaction
reversible: true
product: MODEL1310110036#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR IMPC
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000269
modifier: MODEL1310110036#
name: IMP cyclohydrolase
is version of: http://identifiers.org/ec-code/2.1.2.3
is: SBO:0000176
type: Reaction
fast: false

metaR GTHDH
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
product: MODEL1310110036#
is described by: ECO:0000134
name: Glutathione dehydrogenase (dehydroascorbate reductase)
fast: false
reactant: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#

metaM nad e
is: CHEBI:57540
initial concentration: 1.0
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: HMDB00902
constant: false
name: NAD(1-)
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN

metaR THYOXt
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
name: T4 transport via bicarbonate countertransport
kinetic law: MODEL1310110036#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_9123c74c_92e8_4b3f_89f0_5282edd86b68
is: Q5JPH6
initial amount: NaN
type: Species
is encoded by: hsa:124454
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: EARS2
constant: false
boundary condition: true

metaR r0706
is: SBO:0000176
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
modifier: MODEL1310110036#
type: Reaction
reversible: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.10
reactant: MODEL1310110036#
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6

metaM ppa c
initial concentration: 1.0
type: Species
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
is: CHEBI:17272
has only substance units: false
name: propionate
is: SBO:0000247
constant: false
is: HMDB00237
initial amount: NaN

metaR r2357
fast: false
reversible: true
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_a6ebf79b_41db_4b8a_98ba_a1330973817b
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:2653
is encoded by: hsa:2731
has part: P23434
type: Species
is: SBO:0000297
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has part: P48728
has part: P23378
is encoded by: hsa:275
has only substance units: false

metaM 2oxoadp c
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
name: 2-oxoadipate(2-)
type: Species
initial concentration: 1.0
is: HMDB00225
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57499

metaR r0686
type: Reaction
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.2.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
reactant: MODEL1310110036#

metaR r1630
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_80364330_92ca_4a68_8fdb_839d4344d89e
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: AK5
is encoded by: hsa:26289
is: SBO:0000252

metaR PYNP2r
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
name: pyrimidine-nucleoside phosphorylase (uracil)
is version of: http://identifiers.org/ec-code/2.4.2.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is: SBO:0000176
type: Reaction
reversible: true

metaR r1567
fast: false
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR PRASCS
modifier: MODEL1310110036#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.2.6
fast: false
reversible: true
product: MODEL1310110036#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
type: Reaction

metaR ALAGLNexR
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185
product: MODEL1310110036#
name: L-alanine/glutamine reversible exchange
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000304
reversible: true
fast: false

metaM xol7ah2 m
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB06893
name: 5beta-cholestane-3alpha,7alpha-diol
initial amount: NaN
has only substance units: false
is: CHEBI:28047
constant: false
initial concentration: 1.0

metaM tdchola c
type: Species
is: HMDB00951
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:9407
initial amount: NaN
name: taurochenodeoxycholate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

metaM Rtotal e
type: Species
has only substance units: false
notes: FORMULA: CO2FULLR CHARGE: -1
is: C00255
boundary condition: false
is: SBO:0000247
name: R total
is: HMDB00244
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:3554

http://identifiers.org/biomodels.db/MODEL1310110036#_1748e9d9_888f_4697_a936_f8fde0713e94
name: PIK3R1
initial amount: NaN
is encoded by: hsa:5295
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: E7EX19
boundary condition: true
constant: false

metaM 5mthf c
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01396
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H24N7O6 CHARGE: -1
name: 5-Methyltetrahydrofolate
is: C00440
is: CHEBI:3729
type: Species

metaM dcsptn1crn m
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06321
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaR PETHCT
modifier: MODEL1310110036#
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110036#
type: Reaction
name: phosphoethanolamine cytidyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.14
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_e8583236_6da4_4772_8625_7110ecc0517b
name: GALT
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2592
is: B2RAT6
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_4c29941a_d793_4856_bb01_65a31bd532a7
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5313
has only substance units: false
constant: false
is: P30613
name: PKLR
type: Species
boundary condition: true
is: SBO:0000252

metaM ppi x
boundary condition: false
is: HMDB00250
initial amount: NaN
name: Diphosphate
is: SBO:0000247
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
has only substance units: false
constant: false
is: C00013
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_c63b1f90_3e78_42b0_8089_3bd21e453655
is encoded by: hsa:AI620219
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: _AI620219_1_e
has only substance units: false
initial amount: NaN

metaR GLACter
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#

metaR ARACHCRNt
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110036#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_96d2ffa3_7bc7_4ba7_8d70_767b12976d82
initial amount: NaN
name: _AI990637_1_x
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI990637
boundary condition: true
has only substance units: false

metaM pe hs m
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16038
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
has only substance units: false
constant: false

metaR DURIt
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
type: Reaction
name: deoxyuridine transport via diffusion
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#

metaM glyc e
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:17754
initial concentration: 1.0
type: Species
constant: false
name: Glycerol
is: HMDB00131
is: SBO:0000247

metaR r1569
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000000

metaM xoltriol c
is: HMDB01457
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
boundary condition: false
initial amount: NaN
is: CHEBI:16496
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial concentration: 1.0

metaR GLYCTO1p
name: Glycolate oxidase, peroxisome
is version of: http://identifiers.org/ec-code/1.1.3.15
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
reactant: MODEL1310110036#

metaM nad c
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57540
is: C00003
is: HMDB00902
constant: false
has only substance units: false
name: Nicotinamide adenine dinucleotide
boundary condition: false
is: SBO:0000247
type: Species

metaM mmcoa R m
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01269
is: CHEBI:57326
name: (R)-methylmalonyl-CoA(5-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_fb4cdeab_5ca8_4d97_a02e_fb96aff471d1
name: ADH1B
initial concentration: NaN
has only substance units: false
is encoded by: hsa:125
constant: false
is: SBO:0000252
initial amount: NaN
is: P00325
type: Species
boundary condition: true

metaR r2359
reversible: true
is: SBO:0000185
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_9f9a08cc_c794_43ea_a4ad_8642a8866191
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:3030
is: E9KL44
name: HADHA
boundary condition: true
is: SBO:0000252

metaM pmtcoa r
is: HMDB01338
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00154
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
type: Species
boundary condition: false
is: CHEBI:3454
constant: false
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)

metaR r0797
reactant: MODEL1310110036#
name: glycine N-choloyltransferase EC:2.3.1.65
kinetic law: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_32487688_4431_4172_ae30_19c0d4c3fbd2
is: SBO:0000252
is: D9HTE9
type: Species
is encoded by: hsa:6576
name: SLC25A1
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR ACCOALm
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
product: MODEL1310110036#
is: SBO:0000176
reversible: false
name: acetate-CoA ligase (AMP-forming)
is described by: ECO:0000304

metaM dcsptn1crn c
type: Species
has only substance units: false
constant: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
initial amount: NaN
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_fd1b9657_022a_4386_88d8_94c22c61dad4
boundary condition: true
is encoded by: hsa:23657
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q9UPY5
name: SLC7A11
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_64f6390b_864a_45c0_906f_a42d957c8618
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: DHCR24
is: Q15392
initial amount: NaN
boundary condition: true
is encoded by: hsa:1718

metaR r2009
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM taur x
name: taurine
is: SBO:0000247
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: CHEBI:15891
is: HMDB00251
boundary condition: false
initial concentration: 1.0

metaR r0796
is: SBO:0000176
fast: false
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reactant: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_f596bbf9_0c11_48cf_8a4f_3e4f07f4de93
name: HADHB
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3032
is: P55084
is: SBO:0000252
constant: false
type: Species

metaR r0181
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110036#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#

metaR r1492
name: Utilized transport
type: Reaction
product: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185

metaM acgam r
constant: false
initial concentration: 1.0
initial amount: NaN
name: N-acetyl-D-glucosamine
is: CHEBI:17411
is: SBO:0000247
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
is: HMDB00215
has only substance units: false

metaR r1635
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR BILDGLCURtr
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is: SBO:0000185
product: MODEL1310110036#
name: glucuronidated compound transport
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000

metaR r0932
is: SBO:0000185
name: Transport reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
type: Reaction
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_11618654_2608_4314_a023_5d1198e043e0
name: PANK2
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:80025
initial concentration: NaN
is: Q6P1K9
type: Species
constant: false
is: SBO:0000252

metaR r1788
name: Y+LAT2 Utilized transport
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
is: SBO:0000185

metaR FAOXC200180m
is: SBO:0000176
modifier: MODEL1310110036#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR TYRPHELAT2tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tyrosine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR r2098
is: SBO:0000185
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_23c134b3_5116_4a13_8b89_99a7d73bca00
has part: Q9NS82
type: Species
constant: false
has only substance units: false
name: SLC7A10:SLC3A2
has part: P08195
initial concentration: NaN
is encoded by: hsa:56301
boundary condition: true
is encoded by: hsa:6520
is: SBO:0000297
initial amount: NaN

metaM Rtotal c
name: R total
notes: FORMULA: CO2FULLR CHARGE: -1
is: CHEBI:16189
boundary condition: false
is: HMDB01448
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_b060815c_2e8e_444e_8cde_9645096d6049
is: E9PH29
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: PRDX3
is encoded by: hsa:10935
boundary condition: true

metaM pail4p hs c
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
is: CHEBI:58178
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247

metaM galgluside hs g
name: galactosyl glucosyl ceramide
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: CHEBI:58223
is: HMDB00295
is: C00015

metaM arachdcoa m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57368
is: HMDB06523
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR NTP3e
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000269
modifier: MODEL1310110036#
reversible: false
name: nucleoside-triphosphatase (GTP)
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#

metaM occoa m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01070
is: CHEBI:57386
constant: false
type: Species
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944

metaM HC00822 e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: Chitobiose
is: CHEBI:28681
constant: false

metaR GLCSGLT1le
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaM retn e
initial concentration: 1.0
boundary condition: false
name: all-trans-retinoate
is: CHEBI:35291
has only substance units: false
type: Species
initial amount: NaN
is: HMDB01852
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247

metaR RE3001M
kinetic law: MODEL1310110036#
type: Reaction
reversible: true
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.34
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110036#
name: RE3001
is: SBO:0000176

metaR r1493
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
name: Utilized transport
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_9392e3b0_6540_4631_8db2_51e47e8f2b0a
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: PEMT
type: Species
is encoded by: hsa:10400
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_e8ec75ba_dc13_49c7_865f_215e6c00ea8a
name: NDUFS5
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4725
initial amount: NaN
is: Q6IBA0
is: SBO:0000252

metaR r0931
name: Transport reaction
reactant: MODEL1310110036#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000

metaR r1634
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110036#
type: Reaction

metaR LNSTLSr
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
name: lanosterol synthase
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/5.4.99.7
is described by: ECO:0000134
modifier: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#

metaR AKR1D2
is: SBO:0000176
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.3
kinetic law: MODEL1310110036#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_736badb7_7fcd_42d4_ba1c_fd3320290424
initial amount: NaN
is encoded by: hsa:84649
constant: false
is: SBO:0000252
is: Q96PD7
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: DGAT2

metaR ACOX22x
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
is: SBO:0000176
name: acyl-Coenzyme A oxidase 2, branched chain
kinetic law: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
is version of: http://identifiers.org/ec-code/1.17.99.3
reactant: MODEL1310110036#

metaR r2099
reversible: true
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
fast: false
modifier: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR 3HCO3 NAt
name: 3HCO3_NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
kinetic law: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
type: Reaction
reversible: true
product: MODEL1310110036#
is described by: ECO:0000134

metaR ACALDt
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110036#
type: Reaction
fast: false
reversible: true
name: acetaldehyde reversible transport
is described by: ECO:0000000
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_a900c7ec_26df_4741_80bc_f4017b97817a
name: SLC2A2
is: P11168
initial concentration: NaN
is encoded by: hsa:6514
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR r1633
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_d10868aa_d854_49c9_ac20_7547ba7a83ef
name: SLC26A6
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9Y3Y1
boundary condition: true
is encoded by: hsa:65010

metaM HC01409 m
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
is: CHEBI:27540
has only substance units: false
name: Hexanoyl-CoA
initial concentration: 1.0
constant: false

metaM HC01401 m
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: CHEBI:27668
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_ccebd1a9_76fd_412a_8aa8_afdfd3ae058c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:759
constant: false
type: Species
initial concentration: NaN
is: P00915
name: CA1
boundary condition: true
initial amount: NaN

metaR r0934
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110036#
fast: false
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d8a2ccaf_5232_4d6b_accc_adbf2861c971
is encoded by: hsa:27124
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: INPP5J

http://identifiers.org/biomodels.db/MODEL1310110036#_e37b2626_fec6_49cb_8303_71296fad1e14
is: Q9NPH0
is encoded by: hsa:51205
boundary condition: true
name: ACP6
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM arachd x
has only substance units: false
boundary condition: false
type: Species
name: arachidonate
constant: false
is: HMDB01043
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:32395
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219

metaR GUAPRT
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
kinetic law: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
reversible: false
is: SBO:0000176
name: guanine phosphoribosyltransferase
modifier: MODEL1310110036#

metaR r1847
fast: false
modifier: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: Y+LAT2 Utilized transport

metaR r2193
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM ribflv e
has only substance units: false
initial amount: NaN
is: HMDB00244
initial concentration: 1.0
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
constant: false
is: C00255
name: Riboflavin
is: SBO:0000247
is: CHEBI:3554
boundary condition: false

metaR r2007
reversible: false
modifier: MODEL1310110036#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000000

metaR THYOXt2
type: Reaction
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
is described by: ECO:0000269
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
kinetic law: MODEL1310110036#
name: T4 transport via facilitated diffusion
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_96983755_837d_4ec7_a9be_9008ce93f5d1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P54819
constant: false
initial amount: NaN
name: AK2
is: SBO:0000252
is encoded by: hsa:204
type: Species

metaR r1632
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110036#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#

metaR FAOXC183806m
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110036#
name: Beta oxidation of fatty acid
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110036#_4103120f_da2b_49f3_a2b6_ab7dbba1c906
type: Species
initial concentration: NaN
name: _H45672_1_m
is: SBO:0000252
is encoded by: hsa:H45672
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM adrncoa x
name: adrenyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205480
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
is: C16170
has only substance units: false
initial concentration: 1.0

metaR r0688
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#

metaR r1846
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_758ff796_7206_4813_91fc_1e4afda4030c
is: Q5HYI4
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6713
initial amount: NaN
name: SQLE
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM dcamp c
is: CHEBI:57567
constant: false
initial amount: NaN
is: SBO:0000247
name: N6-(1,2-Dicarboxyethyl)-AMP
is: HMDB00536
initial concentration: 1.0
has only substance units: false
type: Species
is: C03794
boundary condition: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794

metaM CE5117 m
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
is: CHEBI:57923
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial amount: NaN

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_f5087295_e3be_456d_9700_a2f46935ec3b
is: Q14032
initial concentration: NaN
has only substance units: false
name: BAAT
initial amount: NaN
constant: false
is encoded by: hsa:570
boundary condition: true
type: Species
is: SBO:0000252

metaM pail3p hs c
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:58088
constant: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110036#_d611e32c_4d95_4cc6_978d_cfc3a86ce9df
boundary condition: true
has only substance units: false
is encoded by: hsa:130367
initial concentration: NaN
constant: false
is: Q8IWX5
name: SGPP2
initial amount: NaN
is: SBO:0000252
type: Species

metaM hpyr c
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01352
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
type: Species
is: CHEBI:17180
name: 3-hydroxypyruvate
initial amount: NaN

metaM pmtcoa m
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:57379
is: C00154
initial concentration: 1.0
initial amount: NaN
is: HMDB01338

metaR r2005
modifier: MODEL1310110036#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110036#

metaR r2195
modifier: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_d5538b11_299b_40a1_9196_c42a1d79be44
is encoded by: hsa:84532
boundary condition: true
is: Q9NUB1
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ACSS1
constant: false

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM CE1926 c
has only substance units: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
initial concentration: 1.0
is: SBO:0000247
is: HMDB02710
constant: false
type: Species
is: CHEBI:27485
boundary condition: false
initial amount: NaN
name: gama-carboxyethyl-hydroxychroman

metaR RE2626C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000000
name: RE2626
type: Reaction
is: SBO:0000176
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false

metaM fadh2 x
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB01197
name: FADH2(2-)
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: CHEBI:58307
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_5890302c_cc61_452a_874a_c2ba1f3c79d6
boundary condition: true
name: SLC26A1
is encoded by: hsa:10861
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaR HIStN1
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110036#
product: MODEL1310110036#
fast: false
is described by: ECO:0000269
reversible: true
name: Histidine transport (Na, H coupled)

metaR r1639
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#

metaR r2094
is: SBO:0000185
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_ff2ac3c7_af11_4ee0_83e0_6c1e51f3f470
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:34
has only substance units: false
name: ACADM
initial amount: NaN
boundary condition: true
is: P11310

metaM btcoa m
boundary condition: false
name: Butanoyl-CoA
is: C00136
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
is: HMDB01088
constant: false
type: Species
is: CHEBI:57371
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_902a6a96_befa_450e_afc1_86144ca5a03c
is encoded by: hsa:5634
boundary condition: true
is: P11908
has only substance units: false
name: PRPS2
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaM val L m
is: SBO:0000247
name: L-valine
type: Species
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00883
has only substance units: false

metaM CE2838 e
boundary condition: false
initial concentration: 1.0
is: C01936
name: maltononaose
has only substance units: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

metaM malttr e
constant: false
name: maltotriose
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: HMDB01262
is: SBO:0000247
is: CHEBI:27931
is: C01835

metaR r0791
is: SBO:0000176
fast: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_285f15c0_208d_4985_986e_577f93d17da9
initial concentration: NaN
is encoded by: hsa:3945
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:3939
type: Species
name: LDHA:LDHB
is: SBO:0000297
has part: P00338
initial amount: NaN
has part: P07195

metaM 13dpg c
boundary condition: false
type: Species
name: 3-Phospho-D-glyceroyl phosphate
constant: false
is: SBO:0000247
is: CHEBI:57604
initial amount: NaN
is: HMDB01270
is: http://identifiers.org/pubchem.compound/3535
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: C00236

metaR r0186
modifier: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reactant: MODEL1310110036#
reversible: false
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is described by: ECO:0000000
product: MODEL1310110036#

metaR r0033
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
kinetic law: MODEL1310110036#
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110036#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
product: MODEL1310110036#

metaR PGK
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.2.3
is: SBO:0000176
reversible: true
name: phosphoglycerate kinase
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000134
modifier: MODEL1310110036#
type: Reaction

metaM nad m
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
is: C00003
type: Species
has only substance units: false
is: CHEBI:57540
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false

metaM pe hs c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: phosphatidylethanolamine
is: CHEBI:16038
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false
type: Species

metaR GLNtm
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
name: L-glutamine transport via electroneutral transporter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
product: MODEL1310110036#
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110036#

metaR r2196
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110036#
reversible: true
is: SBO:0000185

metaM for c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15740
initial amount: NaN
has only substance units: false
name: Formate
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
boundary condition: false
constant: false
is: HMDB00142
is: C00058

metaR FALDH
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000176
fast: false
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: true
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
product: MODEL1310110036#
name: formaldehyde dehydrogenase
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b45a212d_c77c_4880_a424_f43e6d8fe62e
constant: false
has only substance units: false
is: SBO:0000252
is: P22392
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:4831
initial amount: NaN
name: NME2

metaR r2095
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction

metaR ACACT10m
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110036#

metaR r1638
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction

metaM HC00822 l
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:28681
initial amount: NaN
name: Chitobiose
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaM mlthf m
name: 5,10-Methylenetetrahydrofolate
initial amount: NaN
is: SBO:0000247
is: C00143
constant: false
is: HMDB01533
initial concentration: 1.0
boundary condition: false
is: CHEBI:15636
has only substance units: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_02acacc0_80e8_4054_98cb_baa35abc6089
constant: false
type: Species
is encoded by: hsa:5291
name: PIK3CB
is: B4DER4
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_95ad9a66_7ad9_4930_ad1b_abb0a20d9557
has only substance units: false
type: Species
name: SLC28A2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:9153
is: SBO:0000252
is: O43868
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_1041f266_fd54_407f_93a7_e0de41eb0213
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4713
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: NDUFB7
is: P17568
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a40261cf_7f08_4718_95ad_be6e0fa201b3
is encoded by: hsa:R06874
name: _R06874_1_r
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaM icit m
type: Species
name: Isocitrate
is: C00311
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
constant: false
initial concentration: 1.0
is: CHEBI:16087
initial amount: NaN
boundary condition: false
is: HMDB00193

metaR PNTOte
name: Transport of (R)-Pantothenate
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
type: Reaction

metaM dnad c
is: HMDB01179
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: Deamino-NAD+
is: C00857
constant: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: CHEBI:18304
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_6ea3c1e7_00b4_4b52_b245_ab2df6fade59
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q7LG56
has only substance units: false
constant: false
type: Species
name: RRM2B
is encoded by: hsa:50484

metaR r2197
is: SBO:0000185
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_fd6ef6d7_430d_4787_85ac_ce22255e19bf
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:8525
initial amount: NaN
is: B7Z6M3
is: SBO:0000252
name: DGKZ

metaM pmtcrn x
constant: false
name: L-palmitoylcarnitine
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00222
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

metaR r2352
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110036#

metaR r2096
product: MODEL1310110036#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR r1637
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110036#
type: Reaction

metaM 6a2ohxnt x
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: HMDB12151
has only substance units: false
type: Species
initial concentration: 1.0
name: 6-amino-2-oxohexanoic acid
is: CHEBI:17534
constant: false
is: SBO:0000247

metaM retn c
has only substance units: false
name: all-trans-retinoate
is: HMDB01852
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_e6890823_2975_427c_ae31_035050d12825
is: SBO:0000252
name: _NM_013421_1_e
initial concentration: NaN
is encoded by: hsa:NM 013421
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a461a7e2_cead_4f51_920b_2d3013c3e488
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: Q9NNW7
is encoded by: hsa:10587
initial amount: NaN
initial concentration: NaN
name: TXNRD2

metaM pe hs e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
constant: false
type: Species
name: phosphatidylethanolamine
boundary condition: false
is: SBO:0000247

metaM dgtp e
is: HMDB01440
constant: false
name: dGTP
has only substance units: false
is: SBO:0000247
is: CHEBI:16497
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaM trp L c
initial concentration: 1.0
is: HMDB00929
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:16828
name: L-tryptophan
boundary condition: false
constant: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080

metaM 2oxoadp m
name: 2-oxoadipate(2-)
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57499
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: HMDB00225
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR 3MOPt2im
is: SBO:0000185
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000

metaR r2002
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
modifier: MODEL1310110036#
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_54115b81_0495_4bee_a5d7_5edb7f8a10cc
initial amount: NaN
boundary condition: true
name: SLC25A21
is: G3V4L5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:89874
constant: false
is: SBO:0000252
type: Species

metaM pail45p hs c
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
type: Species
is: CHEBI:28910
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
constant: false

metaR r2198
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
fast: false
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_1b249627_d5d1_4e4f_9552_bcdd84505779
constant: false
name: AMY1A
initial amount: NaN
initial concentration: NaN
is: Q6NSB3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:276
type: Species
boundary condition: true

metaR r1636
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction

metaR r2097
modifier: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#

metaM glyc m
name: Glycerol
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: C00116
is: CHEBI:17754
is: HMDB00131
boundary condition: false
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN

metaR r0539
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
is: SBO:0000176
reactant: MODEL1310110036#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_99b9d683_1ec9_41ca_8896_fc2607beb808
boundary condition: true
is encoded by: hsa:55089
name: SLC38A4
initial concentration: NaN
type: Species
has only substance units: false
is: Q969I6
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_6f457ed9_ecd5_451b_93e2_4c1b22d13e41
is encoded by: hsa:122622
is: SBO:0000252
is: Q8N142
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: ADSSL1
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_ea654c99_b171_4f3e_90c4_7111dfaa1d47
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q99643
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:6391
has only substance units: false
name: SDHC

http://identifiers.org/biomodels.db/MODEL1310110036#_f6ebc8bc_f379_40b5_8f2b_1f6521c82783
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2584
initial amount: NaN
constant: false
name: GALK1
has only substance units: false
type: Species
is: P51570

http://identifiers.org/biomodels.db/MODEL1310110036#_c0bc590e_3383_4629_aac2_68c3151a07ef
is: Q16718
has only substance units: false
constant: false
initial amount: NaN
name: NDUFA5
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:4698

http://identifiers.org/biomodels.db/MODEL1310110036#_0309cc86_84bc_4508_b66a_ea7a1896a899
boundary condition: true
has part: Q8WYR1
is encoded by: hsa:23533
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PIK3R5:PIK3CG
type: Species
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110036#_fdbc840b_85ca_46aa_ba2d_526c27b2c6c9
name: CBS
is encoded by: hsa:875
constant: false
is: Q9NTF0
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r0559
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
reversible: true
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
fast: false

metaR PI34P5K
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.68
type: Reaction
modifier: MODEL1310110036#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110036#

metaR P450SCC1m
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
kinetic law: MODEL1310110036#
fast: false
reversible: true
product: MODEL1310110036#
name: cholesterol monooxygenase
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_a585acef_580a_4acf_b915_0d0d084ed0c3
constant: false
is: P49753
initial concentration: NaN
name: ACOT2
is encoded by: hsa:10965
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

metaR LINOFATPtc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR r1711
product: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
fast: false

metaR SPC HSt
kinetic law: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
product: MODEL1310110036#
is: SBO:0000185
name: sphingosylphosphorylcholine transport (diffusion)
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false
type: Reaction

metaR FRDPtcr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is: SBO:0000185
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000134
fast: false
reversible: true
reactant: MODEL1310110036#
type: Reaction

metaM hexdiac c
is: HMDB00672
is: C08260
initial concentration: 1.0
name: hexadecanediocacid
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H28O4 CHARGE: -2
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_4aad774d_6477_4d37_8711_96881cb26cbe
name: AKR1A1
is encoded by: hsa:10327
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P14550
initial amount: NaN
constant: false
type: Species

metaR r1925
fast: false
type: Reaction
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaM fadh2 r
is: SBO:0000247
is: CHEBI:58307
initial amount: NaN
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
type: Species
is: HMDB01197
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: FADH2(2-)

metaR ARSA
name: Arylsulfatase A
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.8
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110036#
fast: false
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_3a703acc_41eb_45fc_9d8e_78a22a73a9b9
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:80025
name: PANK2
is: SBO:0000252
type: Species

metaM gar c
name: N1-(5-Phospho-D-ribosyl)glycinamide
initial concentration: 1.0
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB02022
is: CHEBI:58457
is: C03838
constant: false
initial amount: NaN
boundary condition: false

metaR PTPATe
type: Reaction
fast: false
name: PTPATe
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110036#
is: SBO:0000176

metaR GLXtp
is: SBO:0000185
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
name: glyoxylate transport, peroxisomal

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR LDH L
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
name: L-lactate dehydrogenase
is: SBO:0000176
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
reactant: MODEL1310110036#
product: MODEL1310110036#

metaM ditp c
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
constant: false
type: Species
is: CHEBI:61382
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB03537

metaM HC02192 e
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: taurolithocholate
is: CHEBI:17179
type: Species
notes: FORMULA: C26H44NO5S CHARGE: -1 INCHI: InChI=1S/C26H45NO5S/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32)/p-1/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1 EHMN_ABBREVIATION: C02592
initial concentration: 1.0
boundary condition: false
constant: false

metaR CHAT
product: MODEL1310110036#
modifier: MODEL1310110036#
name: Choline O-acetyltransferase
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.6
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ

http://identifiers.org/biomodels.db/MODEL1310110036#_14199d6f_3b6a_478c_bca2_bb70e9d8bd04
is encoded by: hsa:AV717590
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
name: _AV717590_1_m
initial amount: NaN

metaM datp m
is: C00131
is: CHEBI:61404
name: dATP
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01532
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species

metaM HC01162 c
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58376
boundary condition: false
type: Species
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110036#_e1e455ee_046f_4b3f_a54d_f1211153159b
is: Q9Y2Q0
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ATP8A1
constant: false
is: SBO:0000252
is encoded by: hsa:10396

metaR RE2660C
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
name: RE2660
is described by: ECO:0000000
reactant: MODEL1310110036#
fast: false
reversible: true
type: Reaction
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_489a77a7_4824_45af_88bf_8a5b12a87931
is: SBO:0000252
name: RBAK
is: Q9NYW8
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:57786
initial concentration: NaN
type: Species
initial amount: NaN

metaM 25aics c
is: SBO:0000247
is: HMDB00797
constant: false
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
has only substance units: false
type: Species
is: C04823
initial amount: NaN
is: CHEBI:58443
boundary condition: false
initial concentration: 1.0

metaM 7thf e
notes: FORMULA: C49H57N13O24 CHARGE: -8
initial concentration: 1.0
constant: false
name: heptaglutamyl folate (THF)
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB06559

metaR r1109
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
fast: false
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_95e8e587_c532_4694_85bf_2128f52e2972
type: Species
initial amount: NaN
is: E9KL48
name: GLUD1
is: SBO:0000252
is encoded by: hsa:2746
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaR r1864
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110036#_2b7c6a00_6d7b_4e79_a59f_d19bd0ee0711
initial concentration: NaN
is encoded by: hsa:790
boundary condition: true
is: P27708
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: CAD
constant: false
type: Species

metaM HC01434 x
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:58931
name: oxalatosuccinate(3-)
is: SBO:0000247

metaM Rtotal2coa c
name: R total 2 coenzyme A
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57876
boundary condition: false
is: SBO:0000247
is: HMDB01564
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_4f0d04fb_069c_4e0b_a990_2ad47597f73d
is encoded by: hsa:22305
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: _22305_1_c
initial concentration: NaN

metaM datp n
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:61404
name: dATP
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species
is: C00131
is: HMDB01532

metaR GLXO2p
reactant: MODEL1310110036#
name: glyoxylate oxidase, peroxisomal
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.3.15
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD
product: MODEL1310110036#

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_e161eba1_9be3_40fa_92f1_90712cc04b53
name: XDH
is encoded by: hsa:7498
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: P47989
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR r2199
fast: false
reversible: true
modifier: MODEL1310110036#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#

metaR FATP3t
is described by: ECO:0000269
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
name: fatty acid electroneutral transport

http://identifiers.org/biomodels.db/MODEL1310110036#_1c5f0edb_863b_4f2b_ae32_fd1bdc786456
initial amount: NaN
is encoded by: hsa:81537
name: SGPP1
constant: false
is: Q9BX95
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_8a1bd2c0_db3d_4f04_b0d4_031abfa25325
initial amount: NaN
is: Q86SK9
name: SCD5
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:79966
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_63754e71_1224_4963_861c_f6cf8f4f5cdd
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q96M32
is encoded by: hsa:122481
has only substance units: false
boundary condition: true
name: AK7
type: Species
constant: false

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_5069ead3_8064_4f79_b165_a1bbee57848b
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is: O75489
name: NDUFS3
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:4722

http://identifiers.org/biomodels.db/MODEL1310110036#_003498e6_2203_424c_8ba8_b0a2a5d97ab6
name: ALDH18A1
boundary condition: true
is: SBO:0000252
is: P54886
initial amount: NaN
has only substance units: false
is encoded by: hsa:5832
initial concentration: NaN
type: Species
constant: false

metaM lys L c
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00182
is: CHEBI:32551

metaR r1922
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110036#
name: Y+LAT2 Utilized transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
modifier: MODEL1310110036#

metaM C05965 e
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 12(S)-HPETE(1-)
is: HMDB04243
has only substance units: false
is: CHEBI:57444

metaM fadh2 m
is: SBO:0000247
is: CHEBI:58307
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
is: HMDB01197
name: Flavin adenine dinucleotide reduced
constant: false
boundary condition: false
type: Species
is: C01352

metaR VALt5m
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
product: MODEL1310110036#
type: Reaction
name: Valine reversible mitochondrial transport
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_f95a66e1_37e5_4914_9e5f_26bfdda00dce
boundary condition: true
has only substance units: false
is: Q6FG42
type: Species
initial concentration: NaN
is encoded by: hsa:4701
constant: false
name: NDUFA7
is: SBO:0000252
initial amount: NaN

metaM pyr m
boundary condition: false
type: Species
is: CHEBI:15361
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
is: C00022
constant: false
initial concentration: 1.0
name: pyruvate
is: SBO:0000247
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

metaR FUM
name: fumarase
reversible: true
modifier: MODEL1310110036#
is: SBO:0000176
fast: false
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_73ae6446_c591_44ff_a92f_27f25688d23f
initial amount: NaN
boundary condition: true
name: SLC25A16
initial concentration: NaN
is: P16260
is encoded by: hsa:8034
constant: false
type: Species
has only substance units: false
is: SBO:0000252

metaR RE1525M
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
name: RE1525
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false

metaR PIter
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
modifier: MODEL1310110036#
name: phosphate transport, endoplasmic reticulum
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000212

metaR RE0453C
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
reversible: true
name: RE0453
kinetic law: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_cb241fe5_7d96_4395_a8d5_073568319ef6
boundary condition: true
is encoded by: hsa:5052
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: PRDX1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_510909d6_10c3_4b76_8cc7_90934d345099
constant: false
is encoded by: hsa:6536
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
name: SLC6A9
boundary condition: true
is: P48067

metaR r0556
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is described by: ECO:0000000
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
product: MODEL1310110036#
is: SBO:0000176

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM tststerone e
constant: false
initial amount: NaN
type: Species
is: CHEBI:17347
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: HMDB00234
name: testosterone
is: SBO:0000247

metaM guln r
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
has only substance units: false
name: L-gulonate
is: CHEBI:13115
type: Species
is: HMDB03290

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM gly e
constant: false
name: Glycine
boundary condition: false
initial concentration: 1.0
is: HMDB00123
is: SBO:0000247
is: CHEBI:3339
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
type: Species
is: C00037
initial amount: NaN

metaR NAIt
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000185
product: MODEL1310110036#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110036#
name: Na+ / iodide cotransport
modifier: MODEL1310110036#

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR EX nad LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide exchange
type: Reaction

metaM glac c
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:18268
name: D-glucurono-6,3-lactone
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: HMDB06355
initial concentration: 1.0
type: Species

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM lys L e
boundary condition: false
is: HMDB00182
name: L-lysinium(1+)
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110036#_f87c3b06_3d02_4f03_bce8_23812125cfbe
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AA081045_1_c
is encoded by: hsa:AA081045
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM lanost r
constant: false
name: lanosterol
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
type: Species
is: CHEBI:16521
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01251
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_1890d3a2_dc97_407b_bf3d_316054f0d9c5
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: D3DX95
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:1103
name: CHAT

metaR r2079
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110036#_d22ed19b_f613_4dfe_8328_d257d61c5d62
initial concentration: NaN
is encoded by: hsa:8639
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q16853
constant: false
name: AOC3
type: Species
is: SBO:0000252

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_967fcf1b_9f6b_4b55_a95a_a956ee395bf3
initial concentration: NaN
constant: false
is encoded by: hsa:285973
has only substance units: false
type: Species
is: Q674R7
initial amount: NaN
boundary condition: true
name: ATG9B
is: SBO:0000252

metaR NP1
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000304
name: nucleotide phosphatase
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1e08cf23_2110_44b1_a592_a56fdc628797
initial concentration: NaN
has only substance units: false
is: O95573
is encoded by: hsa:2181
name: ACSL3
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_9edae8cc_c03e_4de8_98cd_6f27201cb335
is: Q9BZX2
boundary condition: true
is: SBO:0000252
name: UCK2
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:7371
constant: false
initial concentration: NaN

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_58f9dca1_ef5a_457e_a1b0_90800dfa639e
is encoded by: hsa:5291
initial concentration: NaN
has part: B3KT19
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:5295
is: SBO:0000297
name: PIK3CB:PIK3R1
boundary condition: true
has only substance units: false
has part: B4DER4

http://identifiers.org/biomodels.db/MODEL1310110036#_88513b5d_187b_4bcb_8128_8788fd9d0607
name: SC5DL
constant: false
boundary condition: true
initial concentration: NaN
is: Q6GTM5
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:6309

metaM val L e
has only substance units: false
boundary condition: false
name: L-valine
initial concentration: 1.0
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
initial amount: NaN
is: HMDB00883
is: CHEBI:16414
is: SBO:0000247

metaM lnlncg r
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: gamma-linolenate
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
is: HMDB03073
boundary condition: false

metaR G6PPer
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
is: SBO:0000176
name: glucose-6-phosphate phosphatase, edoplasmic reticular
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.3.9
kinetic law: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_fd78bf11_7edb_4a2d_ac7a_2046abaedc79
has only substance units: false
is: SBO:0000252
name: _AI191472_1_c
type: Species
constant: false
is encoded by: hsa:AI191472
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_b4286549_d0f2_4f9b_a921_8ead152dec2f
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2348
has only substance units: false
name: FOLR1
initial concentration: NaN
initial amount: NaN
constant: false

metaM dc2coa m
is: CHEBI:61406
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: trans-Dec-2-enoyl-CoA

metaR RE3003M
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
is: SBO:0000176
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: RE3003

metaR UMPK2n
reversible: true
product: MODEL1310110036#
is described by: ECO:0000269
reactant: MODEL1310110036#
is: SBO:0000176
type: Reaction
name: UMP kinase (CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#

metaR r0558
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
modifier: MODEL1310110036#
fast: false
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#

metaM sphings c
type: Species
is: HMDB00252
name: sphingosine(1+)
is: CHEBI:57756
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial concentration: 1.0
initial amount: NaN

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR r0999
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110036#
name: Facilitated diffusion
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_3bf8fe5b_60d9_4988_b287_91ba12df21d6
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:33
name: ACADL
constant: false
is: P28330
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_2bff08fb_688d_4b54_b455_d2c717fd6c03
is: SBO:0000252
is: E9PEI9
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4047
type: Species
name: LSS
constant: false
initial concentration: NaN

metaM tststerone c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17347
is: HMDB00234
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
name: testosterone
has only substance units: false
constant: false
type: Species
boundary condition: false

metaM gly c
constant: false
initial amount: NaN
is: SBO:0000247
name: Glycine
type: Species
initial concentration: 1.0
is: HMDB00123
boundary condition: false
is: CHEBI:3339
is: C00037
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0

metaM f6p c
constant: false
is: SBO:0000247
is: HMDB00124
is: C00085
has only substance units: false
initial concentration: 1.0
name: D-Fructose 6-phosphate
type: Species
initial amount: NaN
is: CHEBI:57579
is: http://identifiers.org/pubchem.compound/3385
boundary condition: false

metaM HC02192 c
constant: false
has only substance units: false
name: taurolithocholate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C26H44NO5S CHARGE: -1 INCHI: InChI=1S/C26H45NO5S/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32)/p-1/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1 EHMN_ABBREVIATION: C02592
is: CHEBI:17179
type: Species
is: SBO:0000247

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM urea c
boundary condition: false
initial amount: NaN
is: CHEBI:16199
is: HMDB00294
is: SBO:0000247
type: Species
name: Urea
constant: false
has only substance units: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial concentration: 1.0
is: C00086

metaR r1106
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
name: Postulated transport reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110036#
is: SBO:0000185

metaM coa c
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: C00010
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01423
has only substance units: false
name: Coenzyme A
type: Species
is: CHEBI:3312
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_b902b017_a12d_4bd4_82cc_dbc9aca1f07f
has only substance units: false
initial amount: NaN
name: NOS1
is: B4DG68
constant: false
is encoded by: hsa:4842
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM lnlncg l
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:32391
is: HMDB03073
name: gamma-linolenate
initial concentration: 1.0
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426

http://identifiers.org/biomodels.db/MODEL1310110036#_25c81f02_c6b6_4b69_8fbb_a63a06dae175
constant: false
type: Species
is encoded by: hsa:2348
is: P15328
initial concentration: NaN
name: FOLR1
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_5cc39721_9c5d_4ee1_af0e_b21caba4ee71
initial concentration: NaN
constant: false
is encoded by: hsa:3945
is: P07195
name: LDHB
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaM val L c
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: CHEBI:16414
initial amount: NaN
is: HMDB00883
name: L-valine

metaR LNLCCPT2
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
type: Reaction
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110036#
reversible: false

metaM 10fthf e
type: Species
name: 10-formyltetrahydrofolate(2-)
is: CHEBI:57454
is: HMDB00972
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaM HC01434 m
is: SBO:0000247
is: CHEBI:58931
name: oxalatosuccinate(3-)
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
constant: false

metaM 34hpp c
initial amount: NaN
initial concentration: 1.0
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:36242
type: Species

metaR r0552
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is version of: http://identifiers.org/ec-code/1.3.5.1
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000000
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true
modifier: MODEL1310110036#
product: MODEL1310110036#

metaR ORNt3m
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: true
modifier: MODEL1310110036#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
type: Reaction
name: ornithine mitochondrial transport via proton antiport
kinetic law: MODEL1310110036#
product: MODEL1310110036#

metaM 34hpp e
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00707
has only substance units: false
is: CHEBI:36242
type: Species
name: 3-(4-hydroxyphenyl)pyruvate

metaR ADCim
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110036#
name: Acetoacetate decarboxylation (irreversible), mitochondrial
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaM udpgal g
is: CHEBI:58439
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00302
constant: false
type: Species
is: SBO:0000247

metaM urea e
is: SBO:0000247
is: HMDB00294
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
name: Urea
is: C00086
type: Species
is: CHEBI:16199
has only substance units: false
boundary condition: false
constant: false

metaM CE2839 e
is: SBO:0000247
name: maltodecaose
initial amount: NaN
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
boundary condition: false
is: C01936
initial concentration: 1.0
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
type: Species

metaM tststerone r
constant: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial concentration: 1.0
is: HMDB00234
boundary condition: false
is: SBO:0000247
is: CHEBI:17347
name: testosterone

metaR r1570
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d81f8c39_0d42_4474_b556_dc3dde3058ee
boundary condition: true
initial concentration: NaN
name: RPE
is: Q96AT9
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:6120
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_cae0415e_c5cf_4bc6_8be9_10977d7cfcfe
initial amount: NaN
name: PLCB2
is encoded by: hsa:5330
constant: false
boundary condition: true
has only substance units: false
is: Q59F77
is: SBO:0000252
type: Species
initial concentration: NaN

metaM his L e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:15971
name: L-histidine
type: Species
is: HMDB00177
constant: false

metaM cala c
boundary condition: false
is: HMDB00026
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
constant: false
name: N-carbamoyl-beta-alaninate
initial amount: NaN
is: CHEBI:11892
initial concentration: 1.0
type: Species

metaR LDH D
kinetic law: MODEL1310110036#
name: D-lactate dehydrogenase
reversible: true
is version of: http://identifiers.org/ec-code/1.1.2.4
product: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
fast: false
type: Reaction
is described by: ECO:0000304
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_e4a5f859_4890_4f4c_b5b7_e68f7ddf3c68
boundary condition: true
name: SLC7A8:SLC3A2
constant: false
is encoded by: hsa:23428
is: SBO:0000297
type: Species
has only substance units: false
initial amount: NaN
has part: Q86U05
initial concentration: NaN

metaR RE0453N
reversible: true
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
name: RE0453
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110036#_d24c9c3e_0a8c_4ad3_91a1_29032541d685
name: ACADSB
is encoded by: hsa:36
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P45954
has only substance units: false

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM pmtcoa x
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57379
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
type: Species
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
is: HMDB01338
has only substance units: false
boundary condition: false
is: C00154

metaM ditp n
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: HMDB03537
name: dITP(4-)
is: CHEBI:61382
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR r0400
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
modifier: MODEL1310110036#
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is: SBO:0000176
reactant: MODEL1310110036#
reversible: true
type: Reaction
kinetic law: MODEL1310110036#

metaR r0553
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
kinetic law: MODEL1310110036#
is: SBO:0000176
type: Reaction

metaR CYANtm
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: Cyanide transport via diffusion (mitochondrial)
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
reactant: MODEL1310110036#
fast: false

metaM didp c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:28823
is: HMDB03536
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_24671574_558d_42d5_b785_49614f868ea8
is: SBO:0000252
has only substance units: false
is: Q15147
boundary condition: true
constant: false
name: PLCB4
is encoded by: hsa:5332
initial amount: NaN
initial concentration: NaN
type: Species

metaR RE0453M
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
name: RE0453

metaM 10fthf c
is: SBO:0000247
constant: false
is: HMDB00972
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57454
name: 10-Formyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110036#_399f54d9_71c3_4ac2_9616_94c46eda77eb
type: Species
name: SLC25A20
is encoded by: hsa:788
is: O43772
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaM acnam c
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00230
is: CHEBI:35418
name: N-acetylneuraminate
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaM nh4 c
boundary condition: false
is: SBO:0000247
is: CHEBI:28938
initial amount: NaN
type: Species
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: HMDB00051
is: C01342
has only substance units: false
initial concentration: 1.0
name: Ammonium

metaR ST8SIA12
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reactant: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.8
name: Beta-galactoside alpha-2,3-sialyltransferase
reversible: false
kinetic law: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
product: MODEL1310110036#
type: Reaction

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM dcmp n
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
constant: false
initial amount: NaN
name: dCMP(2-)
is: SBO:0000247
boundary condition: false
is: CHEBI:57566
type: Species
has only substance units: false
initial concentration: 1.0

metaM udpgal e
initial concentration: 1.0
is: HMDB00302
constant: false
type: Species
name: UDP-D-galactose(2-)
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

http://identifiers.org/biomodels.db/MODEL1310110036#_ae3632c0_9006_419c_86dc_884c30a6b525
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:8525
is: G3V0F6
is: SBO:0000252
name: DGKZ
type: Species
initial amount: NaN
boundary condition: true

metaM his L c
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00177
boundary condition: false
name: L-histidine
is: SBO:0000247

metaM C05957 r
is: CHEBI:27485
initial amount: NaN
constant: false
has only substance units: false
is: HMDB02710
type: Species
is: SBO:0000247
name: Prostaglandin J2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_8d173b9c_5b3f_4ac3_a15a_ee37e2345d9e
boundary condition: true
initial concentration: NaN
is: P11586
is: SBO:0000252
is encoded by: hsa:4522
constant: false
has only substance units: false
name: MTHFD1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_6136a725_f9d8_42a2_a297_2aff9720d0fb
initial concentration: NaN
is encoded by: hsa:6005
initial amount: NaN
is: Q96E98
boundary condition: true
name: RHAG
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR MI34PP
is: SBO:0000176
name: inositol-3,4-bisphosphate 4-phosphatase
fast: false
is described by: ECO:0000269
product: MODEL1310110036#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.66
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
reactant: MODEL1310110036#

metaR DGULND
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176
name: dehydro-L-gulonate decarboxylase
product: MODEL1310110036#
reversible: true
type: Reaction

metaR RE0926E
reversible: true
modifier: MODEL1310110036#
fast: false
name: RE0926
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000

metaR r1573
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
fast: false

metaR ILETAm
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110036#
name: isoleucine transaminase, mitochondrial
modifier: MODEL1310110036#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
reactant: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000269

metaR ASPTA
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269
reversible: true
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
kinetic law: MODEL1310110036#
name: aspartate transaminase
is: SBO:0000176

metaM gsn c
is: CHEBI:16750
initial amount: NaN
is: C00387
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
name: Guanosine
is: HMDB00133
constant: false
has only substance units: false
boundary condition: false

metaM chol e
type: Species
is: SBO:0000247
name: Choline
has only substance units: false
is: HMDB00097
is: C00114
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_ba69ec6a_91cf_4d3f_9951_0276c8619279
is encoded by: hsa:8802
is: P53597
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: SUCLG1

metaR GLXtm
reactant: MODEL1310110036#
fast: false
reversible: true
product: MODEL1310110036#
name: glyoxylate transport, mitochondrial
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110036#

metaM HC02216 c
name: prostaglandin-f2beta
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: CHEBI:28922

metaM ha deg1 l
is: CHEBI:16336
name: hyaluronan degradation product 1
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C22H33N2O16 CHARGE: -1
boundary condition: false
is: SBO:0000247

metaM nh4 e
type: Species
initial amount: NaN
has only substance units: false
name: ammonium
is: CHEBI:28938
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR NCKt
modifier: MODEL1310110036#
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000185
name: Na+/Ca2+-K+ exchange
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110036#
is described by: ECO:0000269

metaR CHOLt4
modifier: MODEL1310110036#
is described by: ECO:0000269
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: choline, sodium cotransport
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD

metaM mescon m
boundary condition: false
initial amount: NaN
type: Species
name: Mesaconate
is: SBO:0000247
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
has only substance units: false
initial concentration: 1.0
is: CHEBI:36986
constant: false
is: HMDB00749

metaM no e
name: Nitric oxide
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
has only substance units: false
initial amount: NaN
constant: false
is: HMDB03378
initial concentration: 1.0
is: CHEBI:16480
is: C00533

metaR 5MTHFt2le
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000134
reactant: MODEL1310110036#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: 5-methyltetrahydrofolate transport via anion exchange

metaR r1574
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR ANTHte
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
type: Reaction
product: MODEL1310110036#
is: SBO:0000185
name: Transport of anthranilate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR CYTK5n
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is: SBO:0000176
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110036#
name: cytidylate kinase (CMP),nuclear
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000269

metaM gly m
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00123
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: C00037
is: SBO:0000247
constant: false
is: CHEBI:15428
name: Glycine
initial amount: NaN

metaR FADtx
kinetic law: MODEL1310110036#
name: FAD transporter, peroxisomal
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185
fast: false
reactant: MODEL1310110036#

metaR GCCam
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
is described by: ECO:0000269
type: Reaction
name: glycine-cleavage complex (lipoylprotein), mitochondrial

metaM retfa e
constant: false
has only substance units: false
is: CHEBI:15963
type: Species
boundary condition: false
is: HMDB00508
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
name: fatty acid retinol
initial concentration: 1.0
initial amount: NaN

metaR SUCOASm
fast: false
is described by: ECO:0000000
modifier: MODEL1310110036#
reversible: true
name: Succinate--CoA ligase (ADP-forming)
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD

http://identifiers.org/biomodels.db/MODEL1310110036#_211a4ba9_9ae4_464f_8633_d2c3ae538855
initial amount: NaN
constant: false
is encoded by: hsa:10873
type: Species
is: Q6TCH8
boundary condition: true
initial concentration: NaN
name: ME3
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_9bd6100b_8ba7_4db7_8676_0d072132d7d6
type: Species
has only substance units: false
constant: false
is: O75874
initial amount: NaN
name: IDH1
is encoded by: hsa:3417
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM udpgal c
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
boundary condition: false
name: UDP-D-galactose(2-)
has only substance units: false
is: SBO:0000247
is: HMDB00302
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_be7a5697_e19d_4d34_9cd7_623150c937a9
is encoded by: hsa:33
has only substance units: false
type: Species
initial amount: NaN
name: ACADL
boundary condition: true
is: P28330
initial concentration: NaN
constant: false
is: SBO:0000252

metaR 3HBCOAHLm
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_e466de51_55ed_4ab9_8321_b19b3fc3e897
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80347
constant: false
initial concentration: NaN
name: COASY
is: Q13057

metaR r0403
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000176
type: Reaction
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
modifier: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true

metaR RE1804M
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
name: RE1804
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176

metaM cyan m
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide
is: CHEBI:18407
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false

metaR ME1m
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000176
name: malic enzyme (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.38

http://identifiers.org/biomodels.db/MODEL1310110036#_dd2e63ec_70a5_4f81_b596_a2f7ef5ee613
is: Q5MY95
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: ENTPD8
is encoded by: hsa:377841
type: Species
boundary condition: true
initial concentration: NaN

metaM gsn e
is: SBO:0000247
is: C00387
type: Species
initial concentration: 1.0
is: HMDB00133
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
constant: false
name: Guanosine
boundary condition: false
initial amount: NaN
is: CHEBI:16750
has only substance units: false

metaM abt c
name: L-arabinitol
is: HMDB01851
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403
initial concentration: 1.0

metaM dadp c
type: Species
is: HMDB01508
is: C00206
boundary condition: false
initial concentration: 1.0
is: CHEBI:57667
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
name: dADP
initial amount: NaN

metaR r1571
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM C05280 m
is: CHEBI:28002
is: SBO:0000247
boundary condition: false
is: HMDB03952
type: Species
name: cis,cis-3,6-Dodecadienoyl-CoA
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM chol c
has only substance units: false
type: Species
name: Choline
is: SBO:0000247
is: HMDB00097
initial concentration: 1.0
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: CHEBI:15354
boundary condition: false
constant: false

metaM lys L m
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:32551
initial amount: NaN
name: L-lysinium(1+)
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_17e08375_dc6c_4367_b9b3_e36e0bc64c95
type: Species
boundary condition: true
name: NDUFA4L2
is: Q9NRX3
initial concentration: NaN
is encoded by: hsa:56901
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaR RE3624M
fast: false
name: RE3624
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110036#
reversible: false
modifier: MODEL1310110036#

metaM HC02216 e
name: prostaglandin-f2beta
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:28922
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN

metaM thcholstoic c
constant: false
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
type: Species
is: SBO:0000247
is: CHEBI:18402
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_4c201f30_f9ff_48be_8b39_8e4df660f2f0
has only substance units: false
initial concentration: NaN
is: P47895
boundary condition: true
is encoded by: hsa:220
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
name: ALDH1A3

metaR 2AMADPTm
modifier: MODEL1310110036#
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877

http://identifiers.org/biomodels.db/MODEL1310110036#_e00e5335_f50b_40ae_b3c1_6146df9184c3
initial concentration: NaN
constant: false
initial amount: NaN
is: P00414
type: Species
is: SBO:0000252
name: COX3
is encoded by: hsa:4514
has only substance units: false
boundary condition: true

metaM no c
is: CHEBI:16480
has only substance units: false
boundary condition: false
type: Species
is: C00533
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB03378
name: Nitric oxide

http://identifiers.org/biomodels.db/MODEL1310110036#_2b5c5316_4bc9_46df_b363_fe59f7729a81
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: Q96CA6
name: ACAA1
has only substance units: false
is encoded by: hsa:30

metaM L2aadp6sa c
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB01263
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: SBO:0000247
initial amount: NaN
name: L-allysine
has only substance units: false
is: CHEBI:17917

http://identifiers.org/biomodels.db/MODEL1310110036#_dbfb982b_60ab_48bb_bc68_35397c2950d9
boundary condition: true
is: O95169
initial concentration: NaN
is encoded by: hsa:4714
type: Species
name: NDUFB8
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM retfa c
name: fatty acid retinol
initial amount: NaN
is: HMDB00305
is: CHEBI:50211
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
initial concentration: 1.0
constant: false
type: Species

metaR SO4tl
is described by: ECO:0000269
reactant: MODEL1310110036#
name: Sulfate transport (lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
type: Reaction
product: MODEL1310110036#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b8f5bd47_2443_4ddf_93b6_72dfd4db2d85
is: Q9ULD0
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:55753
name: OGDHL
boundary condition: true
initial concentration: NaN

metaR GALt2 2
is: SBO:0000185
modifier: MODEL1310110036#
is described by: ECO:0000269
kinetic law: MODEL1310110036#
fast: false
reversible: true
product: MODEL1310110036#
name: D-galactose transport via proton symport
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
type: Reaction

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR NDPK4n
fast: false
reversible: true
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR CERT1gt
product: MODEL1310110036#
name: ceramide transport protein
is: SBO:0000185
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false

metaR NRPPHRtu
fast: false
is described by: ECO:0000269
product: MODEL1310110036#
type: Reaction
name: Norepinephrine uniport
reactant: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110036#
is: SBO:0000185

metaR LNLCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110036#
reversible: false
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110036#
fast: false

metaM CE2424 m
is: SBO:0000247
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
boundary condition: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
initial amount: NaN
constant: false
is: CHEBI:28387
has only substance units: false
type: Species
is: HMDB11123
initial concentration: 1.0

metaR r2080
product: MODEL1310110036#
fast: false
is: SBO:0000185
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR r2344
fast: false
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

metaR RE2625C
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
name: RE2625
reversible: true
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_de9c12d0_f28b_4c81_b1d4_a42511efe894
type: Species
is encoded by: hsa:H77542
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: _H77542_1_r

http://identifiers.org/biomodels.db/MODEL1310110036#_7bbaf95e_3c3f_4345_af88_d6cbc2f1e375
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q4G1C4
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:284273
name: ZADH2

metaR ACACT1x
reversible: false
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000134

metaR r1578
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
type: Reaction
fast: false
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_da40538f_1186_410f_a482_3b57dc433f92
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q96PE3
constant: false
type: Species
name: INPP4A
boundary condition: true
is encoded by: hsa:3631
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_5af658e5_2e5b_49a2_b43f_ff8c6ed84f21
is: Q9BWD1
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: ACAT2
is encoded by: hsa:39
initial concentration: NaN

metaM 10fthf m
initial concentration: 1.0
is: CHEBI:57454
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
name: 10-formyltetrahydrofolate(2-)
has only substance units: false
constant: false
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaM glyclt c
constant: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: CHEBI:29805
is: HMDB00115
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: glycolate
is: SBO:0000247
has only substance units: false
type: Species

metaM aacoa x
is: CHEBI:57286
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01484
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
name: acetoacetyl-CoA(4-)

metaM met L c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00696
is: CHEBI:16643
constant: false
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
initial amount: NaN

metaM leuktrE4 c
is: SBO:0000247
is: HMDB02200
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57462
boundary condition: false
initial concentration: 1.0
name: leukotriene E4(1-)
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952

metaR r0789
reversible: true
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
reactant: MODEL1310110036#

metaR r2081
modifier: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM HC00229 e
initial amount: NaN
has only substance units: false
name: Isomaltose
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
type: Species
is: CHEBI:28189

metaM HC01376 m
initial concentration: 1.0
is: CHEBI:28692
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
type: Species
is: SBO:0000247
has only substance units: false
name: S-(2-Methylbutanoyl)-dihydrolipoamide
constant: false
initial amount: NaN
boundary condition: false

metaR UMPK
reactant: MODEL1310110036#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110036#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110036#
fast: false
name: UMP kinase
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM glu L e
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
is: SBO:0000247
type: Species
name: L-glutamate(1-)
initial amount: NaN
is: CHEBI:29985
initial concentration: 1.0
constant: false
is: HMDB00148

metaR CYTK1
reactant: MODEL1310110036#
name: cytidylate kinase (CMP)
is described by: ECO:0000269
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110036#
fast: false

metaM Rtotal3coa c
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
has only substance units: false
name: R total 3 Coenzyme A
type: Species
is: CHEBI:16189
constant: false
is: HMDB01448
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR C3STDH1r
product: MODEL1310110036#
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is: SBO:0000176
name: C-3 sterol dehydrogenase (4-methylzymosterol)
fast: false

metaR FACOAL80i
fast: false
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
product: MODEL1310110036#
name: fatty-acid--CoA ligase (octanoate)
reversible: false
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000269

metaM xu5p D c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
type: Species
constant: false
name: D-xylulose 5-phosphate(2-)
boundary condition: false
is: HMDB00868
is: CHEBI:57737
initial amount: NaN
has only substance units: false

metaM arachcoa c
has only substance units: false
is: HMDB04258
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
type: Species
name: arachidyl coenzyme A

metaR FORtr
reactant: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110036#
name: FOR transporter, endoplasmic reticulum
type: Reaction
fast: false

metaM abt e
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403
is: SBO:0000247
name: L-arabinitol
initial amount: NaN
boundary condition: false
is: HMDB01851

metaR SERGLYexR
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: L-Serine/Glycine reversible exchange
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_deab1126_39e0_4592_99a0_64a34de6aa39
initial amount: NaN
is encoded by: hsa:57419
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: SLC24A3
is: Q9HC58
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_a53035f5_15f5_402f_952f_61f90b2352a2
initial amount: NaN
name: TMEM54
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:113452
is: Q969K7

http://identifiers.org/biomodels.db/MODEL1310110036#_3451d633_a79d_4125_9c9e_dd7554bb0a76
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6560
type: Species
name: SLC12A4
is: F5H066
boundary condition: true
is: SBO:0000252
constant: false

metaM cyan c
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
initial amount: NaN
is: HMDB02084
name: hydrogen cyanide
is: CHEBI:18407
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_3c901cf5_7e5e_4c24_b234_b07697129f84
boundary condition: true
is encoded by: hsa:27068
has only substance units: false
name: PPA2
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaR CYTK2
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
name: cytidylate kinase (dCMP)
reversible: true
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR DM dttp m
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_5b7fba16_565e_4bf7_8dcb_8d641fd71597
is encoded by: hsa:1635
initial amount: NaN
is: P32321
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: DCTD
has only substance units: false
boundary condition: true

metaR r1576
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#

metaR NMNATr
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.7.1
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nicotinamide-nucleotide adenylyltransferase
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: true

metaM cholcoa x
is: SBO:0000247
is: CHEBI:57373
initial concentration: 1.0
name: choloyl-CoA(4-)
is: HMDB01374
constant: false
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial amount: NaN

metaM leuktrE4 e
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false
boundary condition: false
is: HMDB02200
initial amount: NaN
is: SBO:0000247
is: CHEBI:57462
initial concentration: 1.0
constant: false
type: Species
name: leukotriene E4(1-)

metaM his L m
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:15971
boundary condition: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
is: SBO:0000247
initial concentration: 1.0
is: HMDB00177

http://identifiers.org/biomodels.db/MODEL1310110036#_728e884b_968b_4747_a1ff_3f61181190d3
initial concentration: NaN
is: P07451
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
type: Species
name: CA3
is encoded by: hsa:761

metaM CE2705 n
boundary condition: false
has only substance units: false
is: CHEBI:15374
type: Species
initial concentration: 1.0
name: quinonoid dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: HMDB02281
initial amount: NaN
is: SBO:0000247
constant: false

metaM coa n
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB01423
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
is: SBO:0000247
is: CHEBI:57287
name: coenzyme A(4-)
initial amount: NaN

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_cffcba8a_eb99_44f4_b910_2aa3df709bdd
is encoded by: hsa:10587
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: TXNRD2
is: SBO:0000252

metaR r2341
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#

metaR CYTK3
is: SBO:0000176
type: Reaction
name: cytidylate kinase (CMP)(GTP)
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_0f67d325_d308_4232_9687_ee4080ad3bb8
initial amount: NaN
type: Species
name: NDUFS7
is: SBO:0000252
has only substance units: false
is: O75251
is encoded by: hsa:374291
constant: false
initial concentration: NaN
boundary condition: true

metaM glu L c
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29985
initial amount: NaN
constant: false
is: HMDB00148
boundary condition: false

metaR r0670
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
kinetic law: MODEL1310110036#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_aea03e2a_ba07_486b_afce_ff98e76430d6
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29925
constant: false
type: Species
is: Q9Y5P6
has only substance units: false
name: GMPPB
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_9b6a6951_0b4f_42d3_bd51_e2e280bcfc6e
is: SBO:0000252
is: Q9Y217
constant: false
is encoded by: hsa:9107
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: MTMR6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_cb9e1238_81d6_4e2e_9666_2055c2a73ef8
constant: false
initial amount: NaN
is encoded by: hsa:9791
name: PTDSS1
is: SBO:0000252
is: P48651
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaR r1575
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR SGALSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
name: sgalside hs intracellular transport
product: MODEL1310110036#
is: SBO:0000185
fast: false
type: Reaction

metaM fadh2 c
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
type: Species
is: HMDB01197
is: CHEBI:58307
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR CYTK5
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
product: MODEL1310110036#
name: cytidylate kinase (dCMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000269

metaM glcur c
is: HMDB00127
constant: false
boundary condition: false
initial amount: NaN
name: D-glucuronate
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species

metaM cyan e
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
is: CHEBI:18407
constant: false
boundary condition: false
has only substance units: false
name: hydrogen cyanide
initial concentration: 1.0

metaR CITt4 4
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000006
name: citrate transport via sodium symport
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
product: MODEL1310110036#

metaR C204CRNt
name: arachidonic acid transport into the mitochondria
product: MODEL1310110036#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport

metaR SGALSIDEtg
fast: false
reactant: MODEL1310110036#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
name: sgalside hs intracellular transport
product: MODEL1310110036#

metaR r1429
fast: false
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
product: MODEL1310110036#
reversible: true

metaM arachd c
type: Species
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01043
name: arachidonate
initial concentration: 1.0
is: CHEBI:32395
initial amount: NaN

metaR VALTAm
modifier: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
name: valine transaminase, mitochondiral
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_785b2df2_48ef_454f_afd2_f95d8b483300
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:C7orf24
is: SBO:0000252
name: _C7orf24_1_m

http://identifiers.org/biomodels.db/MODEL1310110036#_07a6c37d_ba0f_4cb5_96e6_b64490eb3b8f
is: P20020
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:490
initial amount: NaN
name: ATP2B1

W3 CDTF: Thu Aug 30 18:00:21 BST 2012

metaR FBA4
product: MODEL1310110036#
type: Reaction
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110036#

metaR RE2954C
reversible: true
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
is described by: ECO:0000000
fast: false
name: RE2954
kinetic law: MODEL1310110036#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40

http://identifiers.org/biomodels.db/MODEL1310110036#_9424cf4a_23dd_4531_a0e9_00b993993077
is: SBO:0000252
type: Species
boundary condition: true
is: P23434
initial concentration: NaN
name: GCSH
initial amount: NaN
has only substance units: false
is encoded by: hsa:2653
constant: false

metaM 4hpro LT m
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: HMDB00725
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18095
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
name: trans-4-hydroxy-L-proline

metaR r0474
kinetic law: MODEL1310110036#
fast: false
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR r1641
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#
fast: false
reversible: true
type: Reaction
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110036#

metaR ASPTAm
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: aspartate transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110036#
reversible: true
type: Reaction
is: SBO:0000176
fast: false

metaR CMPACNAtg
reversible: true
type: Reaction
name: CMP-Sia Golgi transport via CMP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#

metaR CYTK4
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110036#
name: cytidylate kinase (dCMP)(GTP)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_16efe74d_d8eb_4e5f_b851_197afb2fedfa
initial concentration: NaN
type: Species
is: P00338
constant: false
initial amount: NaN
name: LDHA
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3939
boundary condition: true

metaR RE2660N
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
type: Reaction
modifier: MODEL1310110036#
name: RE2660
is: SBO:0000176
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.96

metaR r0330
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#

metaR CYTK6
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
name: cytidylate kinase (CMP,CTP)

metaM asn L m
type: Species
boundary condition: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
initial amount: NaN
is: HMDB00168
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17196

metaR r2347
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000000

metaR AMPtp
reversible: true
kinetic law: MODEL1310110036#
name: AMP transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
fast: false

metaM HC02121 c
boundary condition: false
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758
is: SBO:0000247
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180

metaM cholcoa r
name: choloyl-CoA(4-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57373
is: SBO:0000247
type: Species

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaM lthstrl r
has only substance units: false
is: SBO:0000247
is: HMDB01170
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
initial concentration: 1.0
is: CHEBI:17168
initial amount: NaN
name: 5alpha-cholest-7-en-3beta-ol
type: Species
boundary condition: false

metaR r1428
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
name: Free diffusion
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false

metaM arg L c
name: L-argininium(1+)
boundary condition: false
is: HMDB00517
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
type: Species
is: CHEBI:32682
initial amount: NaN

metaM dadp n
is: CHEBI:57667
name: dADP(3-)
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
is: HMDB01508
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM arachd e
type: Species
constant: false
is: SBO:0000247
name: arachidonate
is: CHEBI:32395
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: HMDB01043
initial amount: NaN

metaM CE2421 m
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: (3S)-3-hydroxylinoleoyl-CoA
is: CHEBI:30623
is: HMDB02329
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_7dd60e7a_66e7_4294_bbd5_3d86ac087f3e
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:22934
is: P49247
boundary condition: true
initial concentration: NaN
type: Species
name: RPIA
has only substance units: false
constant: false

metaR r0672
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
fast: false
kinetic law: MODEL1310110036#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000176

metaR r1640
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110036#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true

metaR r0475
reactant: MODEL1310110036#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

metaM glcur e
is: HMDB00127
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:15748
boundary condition: false
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

metaR r2346
fast: false
kinetic law: MODEL1310110036#
name: Organic anion transporter 5 Utilized transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_6eef58a5_543d_48ce_ad95_a8a834e51fe2
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI640625
initial amount: NaN
is: SBO:0000252
name: _AI640625_1_c

metaR CYTK7
reactant: MODEL1310110036#
is: SBO:0000176
name: cytidylate kinase (CMP,UTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110036#

metaR r0788
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_d7619a6a_decb_4791_8018_d8904f885342
name: _22305_2_c
is encoded by: hsa:22305
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

metaM dadp m
has only substance units: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
is: CHEBI:57667
is: SBO:0000247
constant: false
boundary condition: false
name: dADP(3-)
initial amount: NaN
initial concentration: 1.0
is: HMDB01508

metaR r1427
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: false
product: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185

metaR DNDPt26m
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via dUDP antiport

metaM omhpal c
notes: FORMULA: C16H30O3 CHARGE: -1
constant: false
type: Species
name: w-hydroxypalmiticacid
is: HMDB06294
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM dmpp x
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: HMDB01120
name: prenyl diphosphate(3-)
constant: false
is: CHEBI:57623
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_0cf61da1_8c62_4c23_bb97_4bdaaf1bf421
boundary condition: true
constant: false
type: Species
is encoded by: hsa:2222
initial amount: NaN
is: SBO:0000252
is: P37268
name: FDFT1
initial concentration: NaN
has only substance units: false

metaM cgly e
is: CHEBI:4047
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB00078
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_47cf2369_9ab6_4d5c_a683_fbd71fa60c05
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4842
is: B4DG68
name: NOS1
type: Species
initial amount: NaN

metaR 34DHXMANDACOX NADP
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
type: Reaction

metaM cmpacna g
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species
boundary condition: false

metaR r1643
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0899
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true
product: MODEL1310110036#
name: Amino acid transporter ATB0+ Facilitated diffusion

metaR 7DHCHSTEROLtr
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
name: cholesterol precursor intracellular transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR r0787
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: false
modifier: MODEL1310110036#
is: SBO:0000176
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
fast: false

metaR CYTK8
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
name: cytidylate kinase (CMP,dATP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110036#
is: SBO:0000176

metaR r1579
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_cf634651_6bf9_4176_b85d_9d964a28b19f
has only substance units: false
is: Q5SPY7
boundary condition: true
constant: false
type: Species
name: ENTPD2
is encoded by: hsa:954
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM hmgcoa m
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: HMDB01375
type: Species
is: SBO:0000247
is: CHEBI:15467
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Hydroxymethylglutaryl-CoA

http://identifiers.org/biomodels.db/MODEL1310110036#_a0422fba_0ff7_4614_a4aa_3b2b59de0e1f
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:83549
boundary condition: true
is: Q5JT09
name: UCK1

metaM coa r
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
is: SBO:0000247
is: HMDB01423
boundary condition: false
initial amount: NaN
name: Coenzyme A
type: Species
initial concentration: 1.0
is: C00010
constant: false
is: CHEBI:57287

http://identifiers.org/biomodels.db/MODEL1310110036#_0b5f808d_88a3_4d67_8811_3ba6b647b023
name: DTYMK
initial amount: NaN
is encoded by: hsa:1841
is: P23919
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaR PMTCOAtx
kinetic law: MODEL1310110036#
fast: false
name: fatty acid intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_9fb58504_4a0f_4add_b2c4_cb0bf5ddbc19
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q9UBF8
has only substance units: false
name: PI4KB
constant: false
boundary condition: true
is encoded by: hsa:5298

http://identifiers.org/biomodels.db/MODEL1310110036#_7bf246df_a7cc_46c1_9397_cf27b66069de
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:29922
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: NME7

metaR DTMPK
is: SBO:0000176
kinetic law: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
reversible: true
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.9
modifier: MODEL1310110036#
name: dTMP kinase
reactant: MODEL1310110036#

MODEL1310110036#
species: metaM dmpp x
species: metaM 7dhchsterol c
species: metaM r5p r
species: metaM methf m
species: metaM HC02216 e
stoichiometry: 0.013183
species: metaM dttp c
species: metaM prpp c
species: metaM bilglcur e
species: metaM his L m
species: metaM CE5121 m
species: metaM glyc R c
species: metaM nrpphr c
species: metaM ocdca c
species: metaM no e
species: metaM lys L x
species: metaM glyc e
species: metaM taur c
name: PIK3CA:PIK3R1
scale: 0
species: metaM 2mb2coa m
species: metaM glc D r
species: metaM CE2431 m
species: metaM creat e
name: ADH1A:ADH1C
species: metaM pglyc hs c
species: metaM HC02203 e
species: metaM co2 x
species: metaM met L c
species: metaM pchol hs c
species: metaM galside hs g
species: metaM bildglcur r
species: metaM strdnccoa m
species: metaM glyald m
species: metaM cytd c
value: -100.0
species: metaM asp L m
name: PIK3CB:PIK3R1
species: metaM 5pmev x
species: metaM dhlam m
species: metaM nad e
species: metaM orot c
species: metaM hLkynr c
species: metaM cholate r
species: metaM 34dhoxmand m
species: metaM gullac c
species: metaM gthrd m
species: metaM tchola c
species: metaM retinol 9 cis c
species: metaM Rtotal2 c
species: metaM CE4792 m
species: metaM itp c
species: metaM lnlncgcoa c
species: metaM 3mox4hoxm c
species: metaM cdp e
species: metaM arachd c
species: metaM dag hs c
species: metaM 4abutn c
species: metaM gly e
species: metaM dcsptn1crn m
species: metaM tyr L c
species: metaM o2 c
species: metaM 3pg c
species: metaM C02528 c
species: metaM 3aib D m
species: metaM fadh2 r
species: metaM sarcs c
species: metaM cholcoa r
species: metaM 5mthf e
species: metaM cala c
species: metaM pi m
species: metaM CE2839 e
species: metaM arg L e
species: metaM ppcoa m
species: metaM dha e
species: metaM glx c
species: metaM dpcoa e
species: metaM glu L c
species: metaM dgsn c
species: metaM tag hs e

metaR r1642
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_d3b3761b_12ee_4c7d_8aa7_f6de29ba4045
is: Q9BYC2
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: OXCT2
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:64064

metaR MI145PP
is: SBO:0000176
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.86
type: Reaction

metaR MI134PP
product: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.57
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
kinetic law: MODEL1310110036#
fast: false
name: inositol-1,3,4-trisphosphate 1-phosphatase
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000269

metaR ACETONEt2
is described by: ECO:0000269
type: Reaction
reversible: true
name: acetone transport via proton symport
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#

metaM air c
is: C03373
initial concentration: 1.0
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:58592
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
constant: false
is: HMDB01235
is: SBO:0000247
boundary condition: false

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaR r0191
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.24
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
reversible: false
type: Reaction

metaM etha c
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: etha[c]
boundary condition: false
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
is: HMDB00149
constant: false
is: CHEBI:57603
initial concentration: 1.0

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_c7019873_aaf3_4ac6_8436_d291e13ce5eb
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:3032
is: P55084
name: HADHB
type: Species
initial concentration: NaN

metaR PNTEH
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.1.92
is: SBO:0000176
type: Reaction
reactant: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
name: Hydrolase Class ( RXN R02973)
reversible: false

metaM cgly c
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
has only substance units: false
type: Species
is: HMDB00078
is: CHEBI:4047
is: SBO:0000247
initial concentration: 1.0
name: L-cysteinylglycine
initial amount: NaN
boundary condition: false

metaM lys L x
name: L-lysinium(1+)
initial amount: NaN
is: HMDB00182
is: SBO:0000247
is: CHEBI:32551
boundary condition: false
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

metaR r2088
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_80148747_602e_439a_a688_939fd141aead
name: HADH
type: Species
is: Q16836
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:3033

metaM gcald c
boundary condition: false
name: glycolaldehyde
initial amount: NaN
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17071
is: HMDB03344
has only substance units: false
type: Species
constant: false

metaM prostgf2 c
boundary condition: false
constant: false
is: HMDB01139
initial amount: NaN
name: prostaglandin F2alpha(1-)
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
is: CHEBI:57404
initial concentration: 1.0
type: Species

metaR ACGAM2E
is described by: ECO:0000269
reversible: true
name: N-acetylglucosamine 2-epimerase
modifier: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (5973.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.8 Confidence Level: 4 AUTHORS: PMID:12499362 NOTES:NCD
reactant: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.8
kinetic law: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_92195b85_80bf_4971_9f4d_77e649d1922e
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:AI971036
boundary condition: true
name: _AI971036_1_m

metaR CLHCO3tex2
fast: false
name: chloride transport via bicarbonate countertransport (2:1)
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
kinetic law: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000304

metaR r1707
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GARFT
type: Reaction
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
modifier: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.2
name: phosphoribosylglycinamide formyltransferase

metaR r0946
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: true
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#

metaR r1645
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_dec18089_1cfb_45d2_882f_a5e76e7f6124
is encoded by: hsa:6561
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: SLC13A1
initial concentration: NaN
is: Q9BZW2
has only substance units: false
constant: false

metaR r1644
kinetic law: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110036#
reactant: MODEL1310110036#

metaR r0781
reversible: true
fast: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176

metaR RTOTALt
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110036#
name: RTOTAL transport
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction

metaM CE2705 c
name: quinonoid dihydrobiopterin
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
type: Species
constant: false
is: CHEBI:36781
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_c5ba3293_c375_4c9f_9608_c5676c3cb9dc
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: MPI
is encoded by: hsa:4351
is: P34949
initial amount: NaN
constant: false

metaM 4mzym int2 r
boundary condition: false
is: HMDB06838
is: SBO:0000247
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
constant: false
type: Species
name: 4-Methylzymosterol intermediate 2
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR r1930
reversible: false
is: SBO:0000185
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110036#
fast: false

metaR XYLTD Dr
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110036#
is described by: ECO:0000000
name: xylitol dehydrogenase (D-xyulose-forming)
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
kinetic law: MODEL1310110036#

metaR OROTGLUt
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134
fast: false
name: OROTGLUt
reversible: true

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM datp c
is: C00131
name: dATP
is: HMDB01532
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

W3 CDTF: Thu Aug 30 18:00:22 BST 2012

metaM cbasp c
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: C00438
is: HMDB00828
is: SBO:0000247
initial amount: NaN
name: N-Carbamoyl-L-aspartate
is: CHEBI:32814
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438

metaR AIRCr
is version of: http://identifiers.org/ec-code/6.3.2.6
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
product: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176
name: phosphoribosylaminoimidazole carboxylase
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110036#

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_075af2ac_e5d3_4cfe_b637_913a33d42a79
has only substance units: false
is encoded by: hsa:5336
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: P16885
type: Species
initial concentration: NaN
name: PLCG2

metaR r2089
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_871172d4_5f75_48c2_b0b5_fc655341b4f7
is: SBO:0000252
name: SLC6A10P
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:386757
initial amount: NaN
has only substance units: false

metaR NADPNe
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.6 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:See EC 3.2.2.5 for NAD nucleosidase
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.2.5
product: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
modifier: MODEL1310110036#
name: NADP nucleosidase,extracellular
is described by: ECO:0000269

metaM gdp m
type: Species
constant: false
is: HMDB01201
is: C00035
is: SBO:0000247
name: GDP
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189

http://identifiers.org/biomodels.db/MODEL1310110036#_59813402_f8ae_421c_81ea_2367591cdb90
is encoded by: hsa:6342
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: SCP2
initial concentration: NaN
is: C9JC79

metaR AICART
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
fast: false
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.1.2.3
is described by: ECO:0000269
is: SBO:0000176
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
type: Reaction
reversible: true
reactant: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM pchol hs c
is: CHEBI:16110
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Phosphatidylcholine
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0

metaR r0784
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
type: Reaction
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
reversible: true
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
modifier: MODEL1310110036#

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR r0193
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
product: MODEL1310110036#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
fast: false
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000000

metaR FAOXC140
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110036#
reversible: false
is: SBO:0000176
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR GCCbim
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110036#
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

W3 CDTF: Thu Aug 30 18:00:22 BST 2012

metaR C14STRr
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.1.70
is: SBO:0000176
product: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000134
name: C-14 sterol reductase
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ

metaR r1423
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false
product: MODEL1310110036#
reversible: false
name: Facilitated diffusion
reactant: MODEL1310110036#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_690a0514_6039_4950_bfda_f9b4d8f17b74
initial amount: NaN
boundary condition: true
name: MTHFS
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10588
is: P49914
constant: false

metaR GLUTCOADHm
modifier: MODEL1310110036#
product: MODEL1310110036#
name: glutaryl-CoA dehydrogenase (mitochondria)
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
fast: false
is: SBO:0000176
kinetic law: MODEL1310110036#
reversible: false
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.3.99.7
reactant: MODEL1310110036#

metaR ASNtm
product: MODEL1310110036#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
name: L-asparagine transport, mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reversible: false
reactant: MODEL1310110036#

metaR TCYNTt
type: Reaction
name: Thiocyanate transport via diffusion (cytosol to extracellular)
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: false
reactant: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
product: MODEL1310110036#

metaM prostgf2 e
boundary condition: false
is: HMDB01139
initial amount: NaN
is: SBO:0000247
name: prostaglandin F2alpha(1-)
is: CHEBI:57404
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
type: Species
constant: false

metaR r0944
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reactant: MODEL1310110036#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR r2086
kinetic law: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110036#

metaR r1647
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
is: SBO:0000185

metaM coa g
name: coenzyme A(4-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:57287
is: HMDB01423
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR r0679
reversible: true
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r0783
modifier: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is: SBO:0000176
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72

metaR GUMTCHOLe
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR RE1526M
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110036#
name: RE1526
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_3d383a18_3e9b_4396_be9b_24001d8dd7e1
is encoded by: hsa:80308
has only substance units: false
type: Species
initial amount: NaN
name: FLAD1
boundary condition: true
is: Q8NFF5
is: SBO:0000252
initial concentration: NaN
constant: false

metaM aacoa m
is: HMDB01484
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57286
name: acetoacetyl-CoA(4-)
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
constant: false
has only substance units: false

metaR ARACHDtr
name: intracellular transport
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR r1291
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
fast: false
name: Postulated transport reaction

metaM cbasp e
has only substance units: false
boundary condition: false
is: HMDB00828
initial concentration: 1.0
name: N-Carbamoyl-L-aspartate
initial amount: NaN
notes: FORMULA: C5H6N2O5 CHARGE: -2
type: Species
constant: false
is: CHEBI:32814
is: C00438
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_6cc8aeb1_41e2_44f8_8b69_309ff89be72a
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:115019
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC26A9
is: Q7LBE3

metaR NADPtru
reactant: MODEL1310110036#
name: NADP transporter, endoplasmic reticulum
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
is: SBO:0000185
fast: false
type: Reaction

metaR ADA
kinetic law: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
type: Reaction
is: SBO:0000176
modifier: MODEL1310110036#
fast: false
name: Adenosine deaminase
is described by: ECO:0000269
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.4
reactant: MODEL1310110036#

metaM zymst r
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
boundary condition: false
name: zymosterol
type: Species
is: CHEBI:18252
is: HMDB06271
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_0f437a13_1b9e_4fba_b078_e9ec0a82095d
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: INPP4B
is encoded by: hsa:8821
is: O15327
initial concentration: NaN

metaR LYSATB0tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Lysine into the intestinal cells by ATB0 transporter
type: Reaction

W3 CDTF: Thu Aug 30 18:00:21 BST 2012

metaM ocdcea r
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
initial amount: NaN
is: HMDB00207
constant: false
name: octadecenoate (n-C18:1)
has only substance units: false
boundary condition: false
is: C00712
is: CHEBI:0
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_342f3ad3_3a8e_4067_971d_d48b316a175f
has only substance units: false
is encoded by: hsa:6567
is: P36021
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: SLC16A2
initial concentration: NaN
is: SBO:0000252

metaM 2mp2coa m
is: HMDB01011
boundary condition: false
initial concentration: 1.0
name: 2-Methylprop-2-enoyl-CoA
initial amount: NaN
type: Species
is: CHEBI:27754
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460

metaM gdpmann c
boundary condition: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
constant: false
has only substance units: false
is: HMDB01163
is: CHEBI:57527
initial concentration: 1.0
is: SBO:0000247
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
type: Species

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM arg L e
initial amount: NaN
name: L-argininium(1+)
has only substance units: false
is: HMDB00517
type: Species
constant: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false
is: SBO:0000247
is: CHEBI:32682
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_f96832f8_801a_46aa_bf08_a583a8f92fcc
is encoded by: hsa:5289
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q8NEB9
initial concentration: NaN
name: PIK3C3
type: Species
constant: false
has only substance units: false

metaM asn L c
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00168
is: CHEBI:17196
initial concentration: 1.0
name: L-asparagine
initial amount: NaN

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constant: false
is: SBO:0000252
initial concentration: NaN
is: E2QC23
type: Species
name: GCAT
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:23464

http://identifiers.org/biomodels.db/MODEL1310110036#_dbc7a249_c463_4865_97cd_fd8e644820ee
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AA526438
initial concentration: NaN
name: _AA526438_1_m
boundary condition: true

metaR ADK3m
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.10
type: Reaction
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110036#
modifier: MODEL1310110036#
name: adentylate kinase (GTP)

metaR r2087
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR r1646
type: Reaction
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110036#
reversible: true
product: MODEL1310110036#
reactant: MODEL1310110036#

metaM 11 cis retfa e
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial concentration: 1.0
is: HMDB00972
constant: false
type: Species
name: fatty acid 11-cis-retinol
is: CHEBI:57454
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_ae64d674_527c_4ebb_8740_3635b8054096
boundary condition: true
has only substance units: false
name: UGT1A1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P22309
type: Species
constant: false
is encoded by: hsa:54658

metaM arg L m
constant: false
initial concentration: 1.0
is: HMDB00517
type: Species
is: CHEBI:32682
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
boundary condition: false

metaM hmgcoa x
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_4eeecea0_a80f_47e6_8d54_e1e74ffb642d
is: Q8TD20
constant: false
initial concentration: NaN
boundary condition: true
name: SLC2A12
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:154091
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_35740f22_f19a_45f9_858f_081972b65787
is: P55084
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3032
name: HADHB
boundary condition: true

metaR MEVK1x
reversible: false
product: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.36
reactant: MODEL1310110036#
name: mevalonate kinase (atp)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110036#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_665bfa6e_a538_4b0b_9296_11abed88ddca
boundary condition: true
initial concentration: NaN
type: Species
name: G6PC3
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:92579
is: Q9BUM1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_6a9e11a2_e683_4b7e_95ff_5a6b101247f6
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5286
type: Species
boundary condition: true
name: PIK3C2A
has only substance units: false
initial amount: NaN
is: O00443

metaR r0892
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.2.27
is described by: ECO:0000000
name: Facilitated diffusion
product: MODEL1310110036#
type: Reaction
reversible: true
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaR GALSIDEtl
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
fast: false
is: SBO:0000185
name: galactocerebroside intracellular transport
reversible: true
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR r1649
fast: false
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110036#

metaR CDIPTr
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.11
type: Reaction
name: phosphatidylinositol synthase (Homo sapiens)
kinetic law: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110036#

metaR ASNPHELAT2tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_d1928da7_f57b_4f49_a291_053bce2fa3e2
is encoded by: hsa:AA977580
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: _AA977580_1_c
is: SBO:0000252

metaR r2084
product: MODEL1310110036#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM coa m
is: C00010
name: Coenzyme A
is: SBO:0000247
boundary condition: false
is: CHEBI:57287
type: Species
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
initial concentration: 1.0

metaR PI4PP
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
name: phosphatidylinositol-4-phosphate 4-phosphatase
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#

metaR r0942
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM dcmp c
is: HMDB01202
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: C00239
constant: false
is: CHEBI:57566
boundary condition: false
name: dCMP
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_6453eb25_762a_47e7_93eb_b54ea777ef46
has only substance units: false
boundary condition: true
is: Q9UMR5
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:9374
is: SBO:0000252
name: PPT2

metaR ALAt2r
product: MODEL1310110036#
is: SBO:0000185
reversible: true
modifier: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000304
name: L-alanine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM 4mzym int1 r
boundary condition: false
initial concentration: 1.0
name: 4-Methylzymosterol intermediate 1
initial amount: NaN
constant: false
is: HMDB06927
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_4c0ae0cc_968f_41c4_b225_9deee0bd28f7
has only substance units: false
is encoded by: hsa:1103
name: CHAT
type: Species
initial concentration: NaN
is: Q6LEN5
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaR NDP10ex
reactant: MODEL1310110036#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110036#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: nucleoside-diphosphatase (IDP), extracellular
is described by: ECO:0000269

metaR PRO1x
product: MODEL1310110036#
is described by: ECO:0000134
reactant: MODEL1310110036#
reversible: false
is: SBO:0000176
name: L-ProlineNAD+ 5-oxidoreductase
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_243b0d68_0c45_437c_a66a_16dc3d2b28e7
constant: false
is encoded by: hsa:D29675
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: _D29675_1_e
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_71d29bb9_66ee_480e_b99d_d5847a8fe7f0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1808
boundary condition: true
has only substance units: false
constant: false
name: DPYSL2
is: B4DR31
type: Species

metaR r0196
reactant: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110036#
reversible: true
product: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is: SBO:0000176
type: Reaction

metaM HC01223 m
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57340
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_d21afb15_bfbf_47cf_ac16_9b09cabc0f92
type: Species
is: O14561
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NDUFAB1
is encoded by: hsa:4706
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_9aa36997_fd4a_42f8_adb4_a4c57b457360
name: _X63359_1_c
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:X63359

metaR LYSOXp
reactant: MODEL1310110036#
fast: false
name: L-lysine oxidase, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_65a46465_299d_48cc_ada5_e876f06525ed
type: Species
name: SLC35D1
is: Q9NTN3
is encoded by: hsa:23169
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR TREHe
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
fast: false
is: SBO:0000176
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.1.28
reversible: false
kinetic law: MODEL1310110036#
name: alpha,alpha-trehalase
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_db5de34c_20ba_4513_bb16_03e4ec17e168
has only substance units: false
is: P35218
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: CA5A
initial amount: NaN
is encoded by: hsa:763
constant: false

metaR GLCURter
reactant: MODEL1310110036#
is: SBO:0000185
name: glucuronate endoplasmic reticular transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110036#_189e11ca_cac1_4b69_a970_0c1f192917aa
name: FOLR1
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:2348
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_664862a8_aabd_4999_a87d_cc9da64b757d
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2348
name: FOLR1

http://identifiers.org/biomodels.db/MODEL1310110036#_a20edc5c_b1b3_4760_b61b_52eceb65943c
initial concentration: NaN
constant: false
is encoded by: hsa:224
name: ALDH3A2
boundary condition: true
is: P51648
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR r0941
type: Reaction
is described by: ECO:0000000
name: Free diffusion
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#

metaR r1648
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
modifier: MODEL1310110036#

metaR r2085
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110036#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR G3PD2m
is: SBO:0000185
notes: GENE_ASSOCIATION: (2820.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES:replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
reversible: false
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000304
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.5.3

metaR BHBtm
is described by: ECO:0000000
is: SBO:0000185
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
type: Reaction
fast: false

metaM asn L e
has only substance units: false
constant: false
name: L-asparagine
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
is: CHEBI:17196
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_31c74bc7_de37_46f5_8597_09fcba8db791
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:953
is: SBO:0000252
has only substance units: false
constant: false
name: ENTPD1
is: Q86VV3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_12cdc59b_d67e_4a99_adbe_c2ece4293076
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9962
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC23A2
type: Species

metaM 4hpro LT e
is: HMDB00725
has only substance units: false
name: trans-4-hydroxy-L-proline
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM hexdiac r
is: C08260
initial amount: NaN
is: SBO:0000247
name: hexadecanediocacid
notes: FORMULA: C16H28O4 CHARGE: -2
constant: false
initial concentration: 1.0
is: HMDB00672
has only substance units: false
type: Species
boundary condition: false

metaM thcholstoic r
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
is: CHEBI:18402

metaR PPAm
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
is described by: ECO:0000269
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
product: MODEL1310110036#
name: inorganic diphosphatase
is: SBO:0000176
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_e9a4f9e8_50f0_4533_81fa_baf2b468e1d1
is encoded by: hsa:55808
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ST6GALNAC1
is: Q9NSC7
initial concentration: NaN

metaR FAOXC204
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000269
kinetic law: MODEL1310110036#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
reversible: false
product: MODEL1310110036#

metaM xan c
initial amount: NaN
is: HMDB00292
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: SBO:0000247
name: Xanthine
is: C00385
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17712
has only substance units: false
type: Species

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR r0940
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185
name: Free diffusion
fast: false
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_cb281164_8543_41dd_bc46_58e734fdcc55
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is: O00750
is encoded by: hsa:5287
initial concentration: NaN
boundary condition: true
type: Species
name: PIK3C2B

http://identifiers.org/biomodels.db/MODEL1310110036#_da3ba220_4343_4c62_aa75_0706d2c54320
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5833
type: Species
boundary condition: true
initial concentration: NaN
name: PCYT2
constant: false
is: F5H8B1
initial amount: NaN

metaR FAOXC14C12x
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR r0780
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
fast: false
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#

metaM gdp n
boundary condition: false
initial concentration: 1.0
name: GDP(3-)
is: CHEBI:58189
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM didp n
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28823
constant: false

metaR r2082
modifier: MODEL1310110036#
fast: false
is: SBO:0000185
product: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR HMGCOASim
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is version of: http://identifiers.org/ec-code/2.3.3.10
is described by: ECO:0000269
product: MODEL1310110036#
name: Hydroxymethylglutaryl CoA synthase (ir)
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_1a491077_9a17_4c8b_998a_e476078741f0
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
name: MVD
is: P53602
initial amount: NaN
is encoded by: hsa:4597
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_36a350aa_3f38_4917_b6c4_be7a71ac08cd
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:1666
is: Q16698
name: DECR1
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR PPAn
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000176
name: inorganic diphosphatase, nuclear
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_c416fc68_20bc_4ca2_a068_5d78a81b4044
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q14642
name: INPP5A
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:3632

metaR r0339
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reactant: MODEL1310110036#
reversible: false
product: MODEL1310110036#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.22
is version of: http://identifiers.org/ec-code/2.3.1.65

http://identifiers.org/biomodels.db/MODEL1310110036#_1dbdec75_bb0c_42de_9723_1ed7581f7100
name: GUSB
has only substance units: false
boundary condition: true
is encoded by: hsa:2990
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: P08236
type: Species

metaR r2083
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR FAS120COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
fast: false
name: fatty-acyl-CoA synthase (n-C12:0CoA)
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110036#

metaM met L e
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00696
name: L-methionine
is: CHEBI:16643
is: SBO:0000247
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_eec8d99f_6bab_442c_ae51_822007f3bdaf
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: ENPP1
initial amount: NaN
is encoded by: hsa:5167
has only substance units: false
is: SBO:0000252
is: P22413

metaM nadp m
initial amount: NaN
is: SBO:0000247
type: Species
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
is: C00006
is: CHEBI:58349
has only substance units: false
is: HMDB00217
boundary condition: false
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

http://identifiers.org/biomodels.db/MODEL1310110036#_294f4571_59ef_4de2_bcb9_f20fe83247b9
name: HSD17B10
is: Q99714
boundary condition: true
is encoded by: hsa:3028
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR MI3PP
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: false
is described by: ECO:0000269
name: myo-inositol 3-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.25
modifier: MODEL1310110036#
type: Reaction
product: MODEL1310110036#

metaR FUMSO4tm
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
is: SBO:0000185
type: Reaction
name: Fumarate:sulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269

metaM 10fthf7glu e
is: CHEBI:57454
name: 10-formyltetrahydrofolate-[Glu](7)
has only substance units: false
is: HMDB00972
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C50H57N13O25 CHARGE: -8
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR RE1519M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: RE1519
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110036#
type: Reaction

metaR RE0830C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110036#
name: RE0830
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_2d898868_e6ae_45e4_bb25_4833f39d8cc0
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: NDUFB2
constant: false
type: Species
is: H7C5B8
is encoded by: hsa:4708
boundary condition: true

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_97277430_3231_4347_9737_a8e94d8a5f23
initial amount: NaN
is: Q86YU0
name: CA7
is: SBO:0000252
has only substance units: false
is encoded by: hsa:766
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaM CE5119 m
name: trans-3-cis-8-tetradecadienoyl-CoA
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57923
is: SBO:0000247

metaM 4h2oglt m
is: SBO:0000247
boundary condition: false
is: HMDB02070
is: CHEBI:17742
name: 4-hydroxy-2-oxoglutarate(2-)
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2

metaR 34HPPte
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
name: Transport of 3-(4-hydroxyphenyl)pyruvate

metaM 4nph e
initial concentration: 1.0
is: CHEBI:57917
is: HMDB01232
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
type: Species
boundary condition: false
name: 4-nitrophenolate
is: SBO:0000247
constant: false

metaM oh1 c
is: SBO:0000247
constant: false
is: C01328
initial concentration: 1.0
boundary condition: false
is: HMDB01039
initial amount: NaN
name: hydroxide ion
has only substance units: false
type: Species
notes: FORMULA: HO CHARGE: -1

metaM arachcoa m
name: arachidyl coenzyme A
initial concentration: 1.0
type: Species
is: HMDB04258
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:15527
is: SBO:0000247
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041

metaR SRTNtu
fast: false
type: Reaction
name: Serotonin uniport
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110036#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_0e353ce5_8a8b_42d0_be97_c4b3a0793dd1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10166
initial amount: NaN
name: SLC25A15
is: Q9Y619
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaR UMPK4
modifier: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (GTP)
reactant: MODEL1310110036#
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_174aa31d_7173_472c_bc87_33b06eeb9778
is: P37837
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: TALDO1
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:6888

http://identifiers.org/biomodels.db/MODEL1310110036#_7ba9929b_8504_4d91_ab1d_013868856621
is encoded by: hsa:125965
has only substance units: false
type: Species
name: COX6B2
initial amount: NaN
initial concentration: NaN
is: Q6YFQ2
boundary condition: true
constant: false
is: SBO:0000252

metaR SCPx
type: Reaction
name: peroxisomal thiolase 2
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ

metaM inost e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: SBO:0000247
type: Species
name: myo-inositol
initial amount: NaN
is: CHEBI:17268
constant: false
boundary condition: false
is: HMDB00211

metaR r0522
is: SBO:0000176
product: MODEL1310110036#
fast: false
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#

metaM 3pg c
is: CHEBI:58272
is: http://identifiers.org/pubchem.compound/3497
name: 3-Phospho-D-glycerate
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00807
initial amount: NaN
boundary condition: false
constant: false
is: C00197
is: SBO:0000247

metaR HAtly
reversible: false
fast: false
kinetic law: MODEL1310110036#
name: hyaluronan transport, extracellular to lysosome
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM 5htrp c
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
constant: false
type: Species
has only substance units: false
is: CHEBI:17780
name: 5-hydroxy-L-tryptophan
is: SBO:0000247
is: HMDB00472
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR DCSPTN1COAtx
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: fatty acid intracellular transport
reversible: true
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction

metaM 4mop e
boundary condition: false
is: HMDB00695
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
has only substance units: false
is: CHEBI:17865
is: SBO:0000247
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
constant: false
initial amount: NaN

metaR PRO Dtde
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
name: D-proline transport, extracellular
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110036#
reversible: true

metaM fru c
is: C00095
constant: false
initial concentration: 1.0
is: SBO:0000247
name: D-Fructose
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
boundary condition: false
has only substance units: false
is: HMDB00660
type: Species
is: CHEBI:15824

http://identifiers.org/biomodels.db/MODEL1310110036#_f1c0e457_8455_4dc2_b37e_d541decfaa77
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:BE966236
boundary condition: true
type: Species
name: _BE966236_1_c
constant: false
initial concentration: NaN

metaR UMPK3
reactant: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
name: UMP kinase (UTP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_218b8103_8f24_47ca_9004_ebdc6aba55d9
has only substance units: false
type: Species
constant: false
is: P06858
initial amount: NaN
boundary condition: true
name: LPL
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4023

http://identifiers.org/biomodels.db/MODEL1310110036#_1c728738_f7f1_49fb_b243_b15493b4c3eb
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:23517
name: SKIV2L2
is: Q3MHC9
initial concentration: NaN

metaR GAL3ST11
is version of: http://identifiers.org/ec-code/2.8.2.11
type: Reaction
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
fast: false
modifier: MODEL1310110036#
name: Galactosylceramide sulfotransferase
reactant: MODEL1310110036#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM ethamp c
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: HMDB00224
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58190
name: ethamp[c]

metaR CYSSNAT5tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR RE3566C
type: Reaction
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000000
name: RE3566
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_2001f787_be0c_4ffa_a333_4613b14aebdb
boundary condition: true
is encoded by: hsa:54677
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: CROT
constant: false
is: E7EQF2

metaR DESAT18 3
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176
reactant: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110036#
fast: false

metaM 13dampp c
is: HMDB00002
is: CHEBI:57484
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: SBO:0000247
has only substance units: false
boundary condition: false
name: trimethylenediaminium
type: Species

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaR UMPK6
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
is: SBO:0000176
fast: false
type: Reaction
name: UMP kinase (dCTP)
is described by: ECO:0000269
product: MODEL1310110036#

metaM HC01104 e
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: 4-nitrophenyl phosphate(2-)
is: CHEBI:61146
is: SBO:0000247
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
type: Species

metaR RE3627M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3627
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
reversible: true
is described by: ECO:0000000

metaM 3dhguln c
is: HMDB06334
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: 3-dehydro-L-gulonate
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
initial amount: NaN
is: CHEBI:57655
type: Species

metaR r1292
is: SBO:0000185
type: Reaction
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: true
name: Postulated transport reaction

metaM inost c
is: SBO:0000247
is: HMDB00211
type: Species
boundary condition: false
has only substance units: false
constant: false
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: CHEBI:17268
initial amount: NaN
initial concentration: 1.0

metaR GGH 10FTHF7GLUe
modifier: MODEL1310110036#
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

http://identifiers.org/biomodels.db/MODEL1310110036#_a17ddc26_f785_4d5e_8b53_cb609d830e98
has only substance units: false
is: P23378
constant: false
name: GLDC
initial concentration: NaN
is encoded by: hsa:2731
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

metaM succ m
constant: false
is: CHEBI:30031
initial amount: NaN
name: Succinate
is: HMDB00254
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
has only substance units: false
is: C00042

metaR CHLPCTD
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.15 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.15
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
type: Reaction
name: choline phosphate cytididyltransferase

metaR COAtg
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
fast: false
kinetic law: MODEL1310110036#
name: CoA transport in Golgi via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction

metaR RE1342C
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
reactant: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction
fast: false
product: MODEL1310110036#
name: RE1342
reversible: true

metaM bamppald c
initial concentration: 1.0
is: HMDB01106
constant: false
initial amount: NaN
boundary condition: false
is: C05665
has only substance units: false
name: beta-Aminopropion aldehyde
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7975
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
type: Species

metaR PI4P3K
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.154
modifier: MODEL1310110036#
fast: false
reversible: false
name: phosphatidylinositol 4-phosphate 3-kinase
kinetic law: MODEL1310110036#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153

metaR r2380
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM ser L e
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
name: L-serine
has only substance units: false
initial concentration: 1.0
is: CHEBI:17115
boundary condition: false
is: HMDB00187
constant: false

metaM pd3 c
boundary condition: false
initial concentration: 1.0
name: Previtamin D3
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB06500

metaM pap g
constant: false
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
initial concentration: 1.0
is: HMDB00061
is: CHEBI:58343
type: Species
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR UMPK5
reactant: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
fast: false
is described by: ECO:0000269
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000176
name: UMP kinase (dATP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR DGAT
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
name: diacylglycerol acyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.20
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: false
product: MODEL1310110036#
modifier: MODEL1310110036#

metaR r1879
name: Y+LAT2 Utilized transport
modifier: MODEL1310110036#
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
reversible: false
is described by: ECO:0000000

metaM ade e
name: adenine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16708
constant: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: HMDB00034
type: Species

metaR r1299
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
product: MODEL1310110036#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
reversible: false

metaR GULNter
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
name: L-gulonate endoplasmic reticular export

http://identifiers.org/biomodels.db/MODEL1310110036#_cf212078_783d_446d_8113_f41004bbcf5c
is: B2RAT6
name: GALT
boundary condition: true
has only substance units: false
is encoded by: hsa:2592
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR FAOXC16OHC16r
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM 34dhmald m
is: http://identifiers.org/pubchem.compound/7903
constant: false
is: C05577
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
initial concentration: 1.0
is: HMDB06242
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 3,4-Dihydroxymandelaldehyde
type: Species
boundary condition: false

metaR NDPK9n
fast: false
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110036#

metaM chsterol c
is: SBO:0000247
is: CHEBI:16113
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: cholesterol
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_36bbd71a_4907_4974_8972_1a5450d19177
is: P17812
is encoded by: hsa:1503
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: CTPS1
initial concentration: NaN
initial amount: NaN

metaR RE1522M
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: RE1522
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
fast: false
type: Reaction

metaR r1981
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_69dc6a93_fd6f_446d_b598_2f2694feb9ab
is encoded by: hsa:4731
initial concentration: NaN
constant: false
name: NDUFV3
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P56181
boundary condition: true

metaR r0730
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reversible: false
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reactant: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_1741dc29_8908_4923_9d86_174ed373709c
has only substance units: false
is: Q9Y6K8
type: Species
name: AK5
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:26289
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_4021a23b_fd1e_4386_9030_c1607b50275d
constant: false
initial concentration: NaN
is encoded by: hsa:23475
is: Q15274
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: QPRT

http://identifiers.org/biomodels.db/MODEL1310110036#_2b210664_2679_46c0_a5fb_a014fb7a5375
is: SBO:0000252
has only substance units: false
is: Q96C36
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:29920
initial amount: NaN
constant: false
name: PYCR2

metaR NDPK1m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
kinetic law: MODEL1310110036#

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_a2e3e6a1_39cc_4b4b_a95e_ca5bfdb6754c
boundary condition: true
is: Q14916
has only substance units: false
is encoded by: hsa:6568
name: SLC17A1
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR r1298
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Vesicular transport
product: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_054f83ec_ed4c_41ff_9146_ce88eb6108ed
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: _642502_1_c
is encoded by: hsa:642502
is: SBO:0000252

metaR THP2Ctp
kinetic law: MODEL1310110036#
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110036#
fast: false
reversible: true

metaM HC02023 r
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
name: Cholesterol-ester-ol
is: CHEBI:46898
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM ade c
name: Adenine
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: C00147
is: HMDB00034
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16708

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR UMPK7
type: Reaction
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110036#
reversible: true
fast: false
reactant: MODEL1310110036#
is: SBO:0000176
name: UMP kinase (dGTP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110036#

metaR RE1709C
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is: SBO:0000176
type: Reaction
name: RE1709
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#

metaM hdca c
constant: false
is: CHEBI:7896
boundary condition: false
is: HMDB00220
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: palmitate
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
type: Species
initial amount: NaN

metaM arachcrn m
type: Species
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial concentration: 1.0
has only substance units: false
name: arachidyl carnitine
constant: false
is: HMDB06460
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r2443
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110036#
reversible: false
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
product: MODEL1310110036#

metaM 5aop m
is: C00430
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17549
type: Species
is: HMDB01149
name: 5-Amino-4-oxopentanoate
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: SBO:0000247
constant: false

metaR RE0456M
fast: false
name: RE0456
reactant: MODEL1310110036#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_d23193f0_71eb_4c92_b029_b7baf1bed568
is encoded by: hsa:8883
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: A8MU28
name: NAE1
has only substance units: false
initial amount: NaN

metaM lnlccrn c
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB06469
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
type: Species
is: SBO:0000247
initial amount: NaN
name: Linoleyl carnitine

metaR PAIL HStn
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol nuclear transport (diffusion)
reactant: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reversible: true
product: MODEL1310110036#

metaR RE3004M
product: MODEL1310110036#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
name: RE3004
type: Reaction
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM glyald c
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01051
is: CHEBI:17378
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
constant: false
boundary condition: false
initial concentration: 1.0
is: C00577
name: D-Glyceraldehyde

metaR 3HKYNAKGAT
reversible: false
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.7
type: Reaction
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000304
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
fast: false

metaR r0523
is described by: ECO:0000000
modifier: MODEL1310110036#
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
product: MODEL1310110036#
is: SBO:0000176
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:

metaR r0732
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
type: Reaction
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110036#
is: SBO:0000176
reversible: false
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaR GALSIDEtg
name: galactocerebroside intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
fast: false
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_378ba4c8_3db4_41bd_a905_a05e13faee7f
initial concentration: NaN
is encoded by: hsa:116369
is: SBO:0000252
is: Q96RN1
constant: false
has only substance units: false
initial amount: NaN
name: SLC26A8
type: Species
boundary condition: true

metaR FAEL183
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
reversible: false
type: Reaction
modifier: MODEL1310110036#
is: SBO:0000176
fast: false
name: fatty-acyl-CoA elongation (n-C18:3CoA)

metaR 5MTHFt
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110036#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
modifier: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
fast: false

metaM thyox L e
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:18332
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: HMDB00248
name: L-thyroxine
constant: false
has only substance units: false
initial amount: NaN

metaR GHMT2r
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.1
reversible: true
name: glycine hydroxymethyltransferase, reversible

metaM nrpphr c
is: HMDB00216
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: Norepinephrine
is: CHEBI:33569
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial amount: NaN
boundary condition: false
constant: false

metaR r0731
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110036#
is: SBO:0000176
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
reactant: MODEL1310110036#
fast: false

metaM ptth m
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: CHEBI:16753
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB03426
name: pantetheine
constant: false

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR FATP2t
fast: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185
reversible: true
name: fatty acid electroneutral transport
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110036#_16b38ae7_536f_4b9b_9f9a_4a941bd724d5
type: Species
name: ACOT6
initial amount: NaN
is encoded by: hsa:641372
boundary condition: true
is: SBO:0000252
is: Q3I5F7
initial concentration: NaN
has only substance units: false
constant: false

metaM chsterol e
name: cholesterol
has only substance units: false
is: HMDB00067
initial concentration: 1.0
type: Species
is: CHEBI:16113
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
constant: false

metaR DTTPtn
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
is: SBO:0000185
name: dTTP diffusion in nucleus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000

metaM ahcys r
is: CHEBI:16680
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: S-adenosyl-L-homocysteine
type: Species
is: HMDB00939
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

metaM fru e
constant: false
is: C00095
initial amount: NaN
name: D-Fructose
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
type: Species
has only substance units: false
boundary condition: false
is: HMDB00660
is: CHEBI:15824

metaR NDPK1n
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
is described by: ECO:0000134
reactant: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110036#
type: Reaction
fast: false
product: MODEL1310110036#
is: SBO:0000176

metaR FUMSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110036#
name: Fumarate:sulfite antiport, mitochondrial
reactant: MODEL1310110036#
is: SBO:0000185
type: Reaction
product: MODEL1310110036#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_0512fbcd_17ab_4791_9b22_2b58af1d8e53
is encoded by: hsa:314
is: O75106
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: AOC2
is: SBO:0000252
initial amount: NaN

metaM acac m
initial concentration: 1.0
name: acetoacetate
is: HMDB00060
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:13705
is: SBO:0000247
constant: false

metaM thf m
is: CHEBI:57453
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00101
boundary condition: false
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
is: HMDB01846

http://identifiers.org/biomodels.db/MODEL1310110036#_7b59dcc0_a4fa_461b_a51c_72108615569b
is: Q9P019
initial concentration: NaN
constant: false
name: PHPT1
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:29085

metaM pap c
has only substance units: false
is: HMDB00061
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: CHEBI:58343
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM fum m
boundary condition: false
is: CHEBI:29806
name: Fumarate
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00134
is: C00122
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122

metaR PRPNCOAHYDm
type: Reaction
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is described by: ECO:0000134
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: false
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_936867eb_3d03_4fda_a234_e965dc16ec63
is: SBO:0000252
is: P30520
type: Species
name: ADSS
initial amount: NaN
constant: false
is encoded by: hsa:159
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_812b3567_da24_4303_8c8c_49e09be57868
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:80025
type: Species
name: PANK2
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_f552b7d3_7734_4b30_9ff4_df453c57f9b7
initial amount: NaN
is encoded by: hsa:57468
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9H2X9
name: SLC12A5

http://identifiers.org/biomodels.db/MODEL1310110036#_3d445336_40c1_4f6b_9caf_0bf3bd69dfd6
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC26A9
is: B3KXK1
constant: false
is encoded by: hsa:115019
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_808c9a6c_cff7_44f8_b21f_632865c3d00c
is: P28331
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4719
name: NDUFS1
type: Species

metaR ETHAK
reversible: false
type: Reaction
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.32
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.82
modifier: MODEL1310110036#
name: Ethanolamine kinase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1119.2) or (55500.1) or (1119.1) or (55224.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.82 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000269
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_6f993082_1791_4eaa_847c_b0f52d3bec53
initial amount: NaN
type: Species
name: CMPK1
has only substance units: false
constant: false
boundary condition: true
is: B2R6S5
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51727

http://identifiers.org/biomodels.db/MODEL1310110036#_2f11b3d7_c788_4f83_9955_6ceab495cb5c
name: SLC35A1
initial concentration: NaN
is encoded by: hsa:10559
type: Species
constant: false
has only substance units: false
boundary condition: true
is: P78382
is: SBO:0000252
initial amount: NaN

metaM 3mop e
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
initial concentration: 1.0
boundary condition: false
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
is: HMDB00491
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:28654

metaM HC02175 e
is: CHEBI:27689
initial concentration: 1.0
type: Species
name: caprate
boundary condition: false
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
constant: false
initial amount: NaN
is: SBO:0000247

metaR NRPPHRt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110036#
reactant: MODEL1310110036#
name: Norepinephrine reversible transport in via sodium symport (1:2)
product: MODEL1310110036#
type: Reaction
reversible: true

metaM gumtchol e
is: http://identifiers.org/pubchem.compound/93131
initial concentration: 1.0
boundary condition: false
name: guar gum-taurocholic acid complex
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2760026H5060045NO2530007S CHARGE: 0

metaM trdox c
name: Oxidized thioredoxin
is: CHEBI:18191
has only substance units: false
boundary condition: false
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_33897048_9a39_4fd4_907b_b1c5c574c88d
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: E9PD84
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:9468
name: PCYT1B

http://identifiers.org/biomodels.db/MODEL1310110036#_4120f0ae_9b7b_4f6d_8250_e3db140c28d2
is: SBO:0000252
name: GPD1
has only substance units: false
is encoded by: hsa:2819
type: Species
is: F8W1L5
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

metaM acac x
is: SBO:0000247
is: HMDB00060
initial amount: NaN
name: acetoacetate
has only substance units: false
constant: false
is: CHEBI:13705
initial concentration: 1.0
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false
type: Species

metaR GCC2cm
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110036#
name: glycine-cleavage complex (lipoamide), mitochondrial
is: SBO:0000176
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
is described by: ECO:0000269

metaM nrpphr e
initial amount: NaN
is: CHEBI:33569
is: HMDB00216
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

metaM 44mzym r
has only substance units: false
initial concentration: 1.0
name: 14-demethyllanosterol
boundary condition: false
is: CHEBI:18364
is: SBO:0000247
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: HMDB01286
constant: false
initial amount: NaN
type: Species

metaR CYTK4n
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,GTP),nuclear
is: SBO:0000176
modifier: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_7abc71cf_e1a3_4537_abd3_51f3e1e86515
name: PPCS
initial concentration: NaN
type: Species
constant: false
is: Q9HAB8
initial amount: NaN
is encoded by: hsa:79717
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM dcsptn1 c
is: SBO:0000247
is: HMDB13123
is: http://identifiers.org/pubchem.compound/5282848
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: false

metaM bhb m
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00011
is: CHEBI:10983

http://identifiers.org/biomodels.db/MODEL1310110036#_f33ea415_30dd_4328_882e_49f0588b7d08
name: SLCO1A2
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6579
is: P46721
is: SBO:0000252
type: Species
constant: false
initial amount: NaN

metaR UGT1A10r
is version of: http://identifiers.org/ec-code/2.4.1.17
is: SBO:0000176
kinetic law: MODEL1310110036#
is described by: ECO:0000134
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
reversible: true
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
modifier: MODEL1310110036#
fast: false
product: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_c20de075_1940_4684_afe4_f7ac03a0ec1d
initial concentration: NaN
has only substance units: false
is encoded by: hsa:29926
boundary condition: true
is: SBO:0000252
name: GMPPA
initial amount: NaN
constant: false
is: Q96IJ6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_d53a2f72_d352_43b2_bc40_c2a98bff0d97
name: _D29675_1_c
constant: false
type: Species
is encoded by: hsa:D29675
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM HC01397 m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27402
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
type: Species
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110036#_b57594db_47ea_4aad_9d36_0475abc089fd
initial amount: NaN
is: Q8N3E9
name: PLCD3
is: SBO:0000252
constant: false
is encoded by: hsa:113026
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_d9de21bd_8142_41a6_b664_aabfaf3ac912
name: ENTPD3
initial amount: NaN
is encoded by: hsa:956
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: O75355
initial concentration: NaN

metaM T antigen g
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: T antigen (core 1)
is: SBO:0000247
is: CHEBI:22783
notes: FORMULA: C14H24NO10X CHARGE: 0

metaM cdp n
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01546
name: CDP(3-)
initial concentration: 1.0
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_8efa4304_41da_4160_82da_abf22844503c
name: HSD3B1
initial amount: NaN
is encoded by: hsa:3283
has only substance units: false
is: SBO:0000252
type: Species
is: P14060
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_5deb4401_2ee5_4de4_87b0_1f74867f13e9
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _LOC727762_1_m
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:LOC727762

metaM alpro m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
is: CHEBI:16882
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
boundary condition: false
name: S-Aminomethyldihydrolipoylprotein

metaM bilglcur c
is: SBO:0000247
constant: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_828ef4a4_5b99_4000_bb89_b4487645a478
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI761708
initial amount: NaN
constant: false
boundary condition: true
name: _AI761708_1_m

metaR CBASPte
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
is: SBO:0000185
fast: false
name: Transport of N-carbamoyl-L-aspartate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110036#
is described by: ECO:0000134

metaR TSTSTERONEtr
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
name: testosterone intracellular transport
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_640dc895_9dbc_49ec_bb23_a7beb5a95c07
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:160728
name: SLC5A8
boundary condition: true
constant: false
type: Species
is: Q8N695
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_b030fb0a_b9b8_4152_8159_7649e85f737c
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
name: SDHB
constant: false
initial amount: NaN
is: P21912
is encoded by: hsa:6390

metaM pnto R c
boundary condition: false
is: SBO:0000247
is: HMDB00210
name: (R)-Pantothenate
initial amount: NaN
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
has only substance units: false
type: Species
is: CHEBI:7916
initial concentration: 1.0
constant: false

metaM 3mop c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
boundary condition: false
type: Species
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
is: HMDB00491
constant: false
initial amount: NaN
initial concentration: 1.0

metaR Q10H2e
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
name: transport of ubiquinol into lymph
is described by: ECO:0000134
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_76c1a3d7_e6cf_4062_a9ca_b605431bc3ed
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: QDPR
is: P09417
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5860
constant: false

metaR TDCHOLAte
reversible: true
is: SBO:0000185
name: bile acid intracellular transport
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110036#

metaR ECOAH12m
reactant: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
product: MODEL1310110036#
is: SBO:0000176

metaM HC02175 c
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27689
type: Species
name: caprate
has only substance units: false
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1

http://identifiers.org/biomodels.db/MODEL1310110036#_2d6f8b85_ffab_4403_8133_ac818c1d233a
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: Q53FV7
boundary condition: true
type: Species
is encoded by: hsa:1375
is: SBO:0000252
name: CPT1B

metaM hdca e
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00220
is: C00249
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1
is: CHEBI:0
has only substance units: false
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0

metaR RE1709N
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709
type: Reaction
reversible: true
kinetic law: MODEL1310110036#

metaR r2519
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
name: Utilized transport
reactant: MODEL1310110036#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
product: MODEL1310110036#

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaR PROSTGE2t
reactant: MODEL1310110036#
fast: false
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110036#
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110036#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110036#

metaM xol7a r
has only substance units: false
is: SBO:0000247
constant: false
name: 20-hydroxycholesterol
boundary condition: false
is: HMDB01496
is: CHEBI:1296
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
type: Species

metaM dcsptn1 e
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoic acid
boundary condition: false
is: HMDB13123
type: Species
is: http://identifiers.org/pubchem.compound/5282848

metaM thym c
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial amount: NaN
has only substance units: false
is: CHEBI:17821
is: SBO:0000247
is: C00178
initial concentration: 1.0
is: HMDB00262
constant: false
type: Species
name: Thymine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_b4fe10ea_55dc_4e2a_a4dd_0ad79c8b3801
initial concentration: NaN
boundary condition: true
name: CMA1
has only substance units: false
initial amount: NaN
is: Q4FEB3
is encoded by: hsa:1215
constant: false
type: Species
is: SBO:0000252

metaM arab L e
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
is: HMDB00646
is: CHEBI:30849
is: SBO:0000247
boundary condition: false
name: L-arabinose
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_4dc913f6_6758_483e_9fa2_115b6ceed473
initial concentration: NaN
is: SBO:0000252
name: _AI539321_1_c
boundary condition: true
is encoded by: hsa:AI539321
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_b5510398_058d_4c86_a537_5ef7bb38cda5
is: SBO:0000252
is: Q7L2M7
initial concentration: NaN
is encoded by: hsa:5211
has only substance units: false
constant: false
name: PFKL
type: Species
boundary condition: true
initial amount: NaN

metaM dutp c
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: C00460
is: HMDB01191
constant: false
type: Species
name: dUTP
has only substance units: false
is: CHEBI:17625
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_c4492657_2c52_436c_9bf2_193098dc1c4b
is encoded by: hsa:4513
is: SBO:0000252
name: COX2
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: Q7GXZ8
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_c72b24b5_1146_4368_b971_ae96102a9bd9
is: Q8TF08
initial amount: NaN
is encoded by: hsa:170712
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: COX7B2

metaR ALDD2y
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.1.36
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reversible: false
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false

metaR DNDPt42m
is: SBO:0000185
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110036#
reversible: false
name: dUTP transport via ADP antiport

metaM pchol hs r
initial amount: NaN
name: Phosphatidylcholine
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
constant: false
has only substance units: false
is: CHEBI:16110
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_df011242_fa10_4a44_9c3d_bdc99048471c
constant: false
type: Species
boundary condition: true
is encoded by: hsa:57818
name: G6PC2
is: SBO:0000252
initial amount: NaN
is: E9PAX2
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_a844f07d_ec53_4407_95bf_d50b10d5c76e
type: Species
initial amount: NaN
initial concentration: NaN
name: GK
boundary condition: true
is encoded by: hsa:2710
is: SBO:0000252
has only substance units: false
is: P32189
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_148a701b_857f_4d3a_8591_aa367c87a949
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:AA278423
initial concentration: NaN
boundary condition: true
name: _AA278423_1_m

http://identifiers.org/biomodels.db/MODEL1310110036#_7ebf8e90_df5a_4c98_ab20_4f58a610a157
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5091
has only substance units: false
type: Species
boundary condition: true
name: PC
is: SBO:0000252

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

metaR r2518
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
reactant: MODEL1310110036#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
is: SBO:0000185
kinetic law: MODEL1310110036#
fast: false
reversible: true
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000000

metaM xoldioloneh c
is: CHEBI:2288
initial concentration: 1.0
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB06887
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453

metaM bilglcur e
constant: false
type: Species
is: SBO:0000247
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR r0413
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
modifier: MODEL1310110036#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
kinetic law: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_ef3b3d6e_9e07_476a_9880_ee8126dc5ef0
boundary condition: true
name: HAO1
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: Q9UJM8
is encoded by: hsa:54363
initial amount: NaN

metaM ser L c
initial concentration: 1.0
name: L-serine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00187
is: CHEBI:17115
type: Species

metaR ALDD2x
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110036#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
name: aldehyde dehydrogenase (acetaldehyde, NAD)
kinetic law: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#

metaR XOL7AH2tm
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110036#
fast: false
reversible: true
type: Reaction

metaM leuktrA4 e
initial amount: NaN
name: leukotriene A4(1-)
is: CHEBI:57463
constant: false
is: HMDB01337
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909

metaM pnto R e
constant: false
initial amount: NaN
has only substance units: false
name: (R)-Pantothenate
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
is: HMDB00210
type: Species
is: CHEBI:7916
initial concentration: 1.0
boundary condition: false

metaR RE2405C
is: SBO:0000176
reversible: false
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.17
modifier: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (54658.1) SUBSYSTEM: Miscellaneous EC Number: 2.4.1.17 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: RE2405

http://identifiers.org/biomodels.db/MODEL1310110036#_8a27bb64_35b5_4430_8270_5e012c425e73
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1103
is: D3DX95
type: Species
name: CHAT
is: SBO:0000252
constant: false
initial amount: NaN

metaR q10h2tc
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: transport of ubiquinol into cytosol
type: Reaction

metaR FAS140COA
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
modifier: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110036#
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C14:0CoA)
fast: false
type: Reaction
reversible: false

metaR FRUt4
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
kinetic law: MODEL1310110036#
fast: false
name: D-fructose transport via sodium cotransport
reversible: true
product: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000185

metaR RE0830N
reactant: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
name: RE0830

metaR ACACT1r
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110036#
product: MODEL1310110036#
name: acetyl-CoA C-acetyltransferase
is: SBO:0000176
reversible: true

metaR FAOXC2051843m
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
reversible: false
name: Beta oxidation of fatty acid
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110036#

metaM nadp r
constant: false
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
type: Species
boundary condition: false
is: HMDB00217
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_3b9e9f77_92a6_4d25_85c6_07929549900f
has only substance units: false
is: Q9BZX2
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7371
boundary condition: true
name: UCK2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_a6203208_4387_42c1_a6d0_2c612a1c0a98
boundary condition: true
is: O76062
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:7108
name: TM7SF2
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_997b8eaf_9ce8_4a56_b332_6a4185262681
is: SBO:0000252
is: Q9H903
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:441024
initial concentration: NaN
name: MTHFD2L
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_a7b43d91_77b5_4078_9049_aa54fa2e4f90
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: CANT1
is: Q8WVQ1
initial concentration: NaN
is encoded by: hsa:124583
constant: false

metaR UMPK2
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110036#
fast: false
name: UMP kinase (CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110036#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_9895ef75_d6cc_4b88_bafd_1db9c2807b98
is: P05091
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:217
name: ALDH2
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_c0ce5da7_1b08_4198_863d_0287ad11ef6e
name: _AA576959_1_c
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AA576959
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR GLCAASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110036#
reversible: false
fast: false

metaM dttp n
initial amount: NaN
is: HMDB01342
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00459
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP
type: Species
constant: false
is: CHEBI:37568

metaM oh1 e
is: SBO:0000247
is: C01328
is: HMDB01039
has only substance units: false
type: Species
boundary condition: false
name: hydroxide ion
constant: false
notes: FORMULA: HO CHARGE: -1
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_ef905bf3_afd5_46f5_94cd_968d06107ab3
has only substance units: false
is: Q9NRF8
name: CTPS2
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:56474
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r0410
is described by: ECO:0000000
reactant: MODEL1310110036#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
type: Reaction
product: MODEL1310110036#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110036#

metaM arachcrn c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
is: HMDB06460
constant: false
name: arachidyl carnitine
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_ea144c55_ebaf_4a7e_82c3_499f1bde2dab
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is: O76082
name: SLC22A5
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:6584

http://identifiers.org/biomodels.db/MODEL1310110036#_a20e4963_6da0_46c6_9974_b701cf67bfa5
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51268
name: PIPOX
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is: Q9P0Z9

metaR DGCHOLte
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true

metaM arab L c
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:30849
name: L-arabinose
type: Species
is: HMDB00646
constant: false

metaR UMPK5n
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110036#
type: Reaction
name: UMP kinase (dATP),nuclear

metaM glyc3p x
is: C00093
boundary condition: false
is: CHEBI:57597
initial concentration: 1.0
type: Species
name: Glycerol 3-phosphate
constant: false
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126
initial amount: NaN
has only substance units: false

metaR CYTK9
is described by: ECO:0000269
reactant: MODEL1310110036#
reversible: true
fast: false
name: cytidylate kinase (CMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176

metaM asp L m
is: CHEBI:29991
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00191
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
is: SBO:0000247

metaR DM dsT antigen g
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_084dbefb_906b_40d8_8b92_36e4cc205239
has part: Q96KJ9
is encoded by: hsa:1337
type: Species
is encoded by: hsa:1351
has part: P20674
has part: Q02221
is encoded by: hsa:1327
is encoded by: hsa:1347
has part: Q6FGA0
has part: Q6YFQ2
has part: P24310
is encoded by: hsa:4514
is encoded by: hsa:1345
has part: Q53YB7
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
initial concentration: NaN
is encoded by: hsa:170712
is encoded by: hsa:1340
has part: P13073
constant: false
is encoded by: hsa:9377
is encoded by: hsa:125965
has only substance units: false
has part: H0UI06
is encoded by: hsa:1339
initial amount: NaN
is: SBO:0000297
has part: P15954
is encoded by: hsa:9167
is encoded by: hsa:1350
is encoded by: hsa:4513
has part: Q7GXY8
has part: Q7Z4L0
has part: Q7GXZ8
has part: P09669
is encoded by: hsa:4512
is encoded by: hsa:341947
has part: Q53XN1
has part: P14854
is encoded by: hsa:1349
boundary condition: true
has part: P00414
has part: P24311
is encoded by: hsa:84701
is encoded by: hsa:1346
has part: Q8TF08
has part: P12074
is encoded by: hsa:1329

metaR PYK
modifier: MODEL1310110036#
is described by: ECO:0000134
product: MODEL1310110036#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reversible: false
name: pyruvate kinase
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.40

metaM imp c
is: SBO:0000247
is: C00130
name: IMP
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial amount: NaN
is: CHEBI:58053
boundary condition: false

metaM 4mop c
is: SBO:0000247
boundary condition: false
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false
is: CHEBI:17865
type: Species
constant: false
initial amount: NaN

metaM lnlccrn m
boundary condition: false
is: SBO:0000247
is: HMDB06469
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
type: Species
constant: false

metaM leuktrA4 c
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57463
name: leukotriene A4(1-)
is: HMDB01337

metaM dttp m
is: CHEBI:37568
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: HMDB01342
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: dTTP
is: C00459
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_dd7b62ce_cfd7_455b_b5ab_956311019d50
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3417
constant: false
has only substance units: false
is: O75874
boundary condition: true
initial concentration: NaN
name: IDH1

metaR B3GNT39g
reversible: false
reactant: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_429ee749_6753_47d6_b267_450bbdea2a01
is: SBO:0000252
name: SLC25A10
is: Q9UBX3
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1468
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_c2a5ecd1_60bd_4fb0_9763_54ed4cf17513
is encoded by: hsa:81490
type: Species
constant: false
is: Q9BVG9
initial amount: NaN
name: PTDSS2
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM CE2432 m
boundary condition: false
is: SBO:0000247
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
has only substance units: false
constant: false
is: CHEBI:57795
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_f5c1bb57_b099_4a75_89ba_1edcaadf783e
is: Q53TV9
is: SBO:0000252
initial concentration: NaN
name: RPE
initial amount: NaN
is encoded by: hsa:6120
boundary condition: true
type: Species
has only substance units: false
constant: false

metaM bhb e
boundary condition: false
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:10983
is: HMDB00011
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

metaR KHte
reactant: MODEL1310110036#
is described by: ECO:0000134
kinetic law: MODEL1310110036#
name: KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
type: Reaction
product: MODEL1310110036#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_d7b05c5f_740d_4d30_8585_ee3bd63adecf
has only substance units: false
is: O95498
name: VNN2
is encoded by: hsa:8875
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_6f248bf8_b9a7_4aaf_a167_e3e12d64e5d4
is encoded by: hsa:AI769281
constant: false
initial amount: NaN
initial concentration: NaN
name: _AI769281_1_e
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

metaR r1655
reactant: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_6f5458fb_26af_4526_8f0e_4cd1aae3b54a
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: PLCH1
constant: false
is: Q4KWH8
has only substance units: false
is encoded by: hsa:23007

metaR FAOXC161802m
type: Reaction
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false

metaM hista e
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
boundary condition: false
initial concentration: 1.0
name: histamium
type: Species
is: HMDB00870
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r0391
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000176
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#

metaR r1544
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_f5222ad0_cb18_460b_8872_a3b2ed093561
is: SBO:0000252
constant: false
is: Q9BYZ2
boundary condition: true
is encoded by: hsa:92483
name: LDHAL6B
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM Sfglutth c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: HMDB01550
is: CHEBI:57688
name: S-formylglutathionate(1-)
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
has only substance units: false

metaM ptth c
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16753
name: pantetheine
is: SBO:0000247
constant: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
boundary condition: false
initial amount: NaN

metaM q10 e
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: HMDB01072
boundary condition: false
name: ubiquinone-10
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: CHEBI:46245
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_1c4711dd_ec40_4f96_b95e_6eac14dfe7b8
name: XDH
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: P47989
is encoded by: hsa:7498
is: SBO:0000252

metaR r2021
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_cfe6cb71_20f4_4734_ae7b_a320a33cadac
is: B4DUG1
is encoded by: hsa:9187
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC24A1
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_7c528cbb_29c4_4f02_91ac_b3a230c7189e
is: P04075
is: SBO:0000252
type: Species
name: ALDOA
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:226
initial concentration: NaN
constant: false

metaR DM atp c
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: DM_atp(c)
is: SBO:0000176
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110036#
fast: false
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_af043d86_64e7_4e4a_80d6_7b90a4390bc4
type: Species
is: Q9GZV3
name: SLC5A7
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:60482
constant: false
boundary condition: true

metaM arach e
initial amount: NaN
is: CHEBI:32360
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02212
type: Species
name: arachidate
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
has only substance units: false

metaR r0287
type: Reaction
modifier: MODEL1310110036#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: false
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110036#

metaM xylt c
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
is: CHEBI:17151
initial amount: NaN
name: xylitol
type: Species
is: HMDB02917

metaR r1654
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR MTHFD2m
product: MODEL1310110036#
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
is described by: ECO:0000254
modifier: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_9aa86c29_5670_4c03_be75_802795c28042
is: SBO:0000252
is encoded by: hsa:27124
has only substance units: false
initial amount: NaN
constant: false
name: INPP5J
type: Species
initial concentration: NaN
is: Q15735
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_81c627df_31ef_46e3_9943_16bb440823bc
boundary condition: true
is: Q8TCD5
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:30833
constant: false
has only substance units: false
is: SBO:0000252
name: NT5C

http://identifiers.org/biomodels.db/MODEL1310110036#_7042d1ba_9ceb_46f0_8212_232c0c90f83a
initial concentration: NaN
is encoded by: hsa:6472
constant: false
boundary condition: true
is: SBO:0000252
name: SHMT2
is: B4DJQ3
type: Species
has only substance units: false
initial amount: NaN

metaR PVD3
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reversible: true
fast: false
product: MODEL1310110036#
name: Previtamin D3 formation
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_d06e2aca_7fa6_4e8f_a73c_def59d0840e7
initial amount: NaN
is encoded by: hsa:9651
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: PLCH2
is: O75038
boundary condition: true
type: Species

metaM HC01397 x
is: CHEBI:27402
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
name: (S)-3-Hydroxyhexadecanoyl-CoA
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r0392
type: Reaction
reversible: true
is: SBO:0000176
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM chlstol r
is: CHEBI:16290
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial concentration: 1.0
is: SBO:0000247
name: 5alpha-cholesta-7,24-dien-3beta-ol
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB06842

metaR r0911
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
is: SBO:0000185
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
name: Facilitated diffusion
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_7f09f727_9130_448a_b61b_319feb708446
is encoded by: hsa:2592
type: Species
initial amount: NaN
name: GALT
has only substance units: false
constant: false
boundary condition: true
is: B4E097
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_53d7131d_e9b7_4807_9edb_332f3f4eba54
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: _HG2846_HT2983_1_m
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:HG2846-HT2983

http://identifiers.org/biomodels.db/MODEL1310110036#_125009ff_e1ba_4ef0_80c4_4e38d272c543
initial concentration: NaN
name: MTMR3
is: SBO:0000252
is encoded by: hsa:8897
boundary condition: true
initial amount: NaN
is: Q13615
constant: false
type: Species
has only substance units: false

metaR ATP1ter
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
name: ADP/ATP transporter, endoplasmic reticulum

metaM HC01408 m
name: 3-Oxohexanoyl-CoA
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:27648
is: SBO:0000247
constant: false

metaM ddsmsterol r
initial amount: NaN
type: Species
is: HMDB03896
is: SBO:0000247
is: CHEBI:27910
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
name: 7-dehydrodesmosterol
initial concentration: 1.0

metaR r0661
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110036#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
is: SBO:0000176

metaR r1653
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_d7e40526_31f3_449d_9690_190e38a2ea26
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:2180
initial concentration: NaN
initial amount: NaN
type: Species
name: ACSL1
is: P33121

http://identifiers.org/biomodels.db/MODEL1310110036#_133528df_cd8a_4467_ab7f_6e9608697f6c
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:43
name: ACHE
is: P22303
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR GLYtm
name: glycine passive transport to mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_39478c68_7c22_449c_915d_79b706fc06f1
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5295
boundary condition: true
constant: false
is: P27986
name: PIK3R1
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_9ac26db2_dbbd_42b2_812c_5786e1c3a5c2
boundary condition: true
name: SLC17A2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: O00624
is encoded by: hsa:10246

http://identifiers.org/biomodels.db/MODEL1310110036#_4b44f2aa_a3c1_4ec2_8a96_69561289ea23
constant: false
boundary condition: true
is: SBO:0000252
name: INPPL1
is: O15357
is encoded by: hsa:3636
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d1544003_9469_44c6_af54_8771f25ba9a3
is: SBO:0000252
type: Species
has only substance units: false
name: _AA177072_1_c
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:AA177072

http://identifiers.org/biomodels.db/MODEL1310110036#_919bf3d6_1892_4fa9_bb91_e1b7bdf0c3f2
initial concentration: NaN
is: P23786
has only substance units: false
is encoded by: hsa:1376
name: CPT2
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_9cec2c6f_f519_4994_9d27_db5f18ff750b
initial amount: NaN
name: _AI620219_1_c
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI620219
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_dfa9649a_65aa_47e9_b0e7_74efb1c3b785
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:AI440329
has only substance units: false
is: SBO:0000252
name: _AI440329_1_r

http://identifiers.org/biomodels.db/MODEL1310110036#_c181e081_79d2_44d3_9c20_4fcb7f0d28ba
has only substance units: false
is encoded by: hsa:51
is: Q15067
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: ACOX1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_3500a99a_ad1f_47c7_998d_1f6567054dc5
is: SBO:0000252
name: SLC2A9
boundary condition: true
is: Q9NRM0
is encoded by: hsa:56606
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaR r1546
is: SBO:0000185
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110036#
is described by: ECO:0000000

metaR MALSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
name: Malate:sulfite antiport, mitochondrial
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_69a3fabc_7fab_4fe5_a2ea_55d19efbe214
boundary condition: true
is encoded by: hsa:4723
is: E5KNH5
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: NDUFV1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_201f2b6b_dc11_4807_a053_1d611ed9b65b
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PYCR1
is encoded by: hsa:5831
constant: false
is: A6NFM2
initial concentration: NaN
has only substance units: false

metaM xylt e
is: SBO:0000247
has only substance units: false
is: CHEBI:17151
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
initial amount: NaN
is: HMDB02917
type: Species
name: xylitol
constant: false

metaR r1652
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#

metaR r0660
fast: false
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110036#
reversible: true

metaM xol7ah c
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
type: Species
name: 7alpha-hydroxy-5beta-cholestan-3-one
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:2290
is: HMDB06892

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaR r0390
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reversible: true
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110036#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
reactant: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_cba74dad_d26f_460c_83ac_f231fa042235
is: O14734
is: SBO:0000252
type: Species
is encoded by: hsa:10005
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: ACOT8

http://identifiers.org/biomodels.db/MODEL1310110036#_c140f277_fecc_46ee_b918_0137a713e3bb
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA081045
type: Species
has only substance units: false
name: _AA081045_1_m
initial amount: NaN
is: SBO:0000252

metaM chsterol r
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
constant: false
name: cholesterol
initial amount: NaN
type: Species
is: CHEBI:16113
is: SBO:0000247
is: HMDB00067

metaM pail hs c
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0
is: CHEBI:57880
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_5f733a20_c549_42d3_b29b_8313f9740755
constant: false
initial amount: NaN
is encoded by: hsa:9583
initial concentration: NaN
name: ENTPD4
is: SBO:0000252
boundary condition: true
is: Q9Y227
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_d5679aa6_4298_4269_98f0_6c9e910b6b49
is: P31937
name: HIBADH
initial amount: NaN
has only substance units: false
is encoded by: hsa:11112
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaM fum c
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial amount: NaN
is: CHEBI:29806
type: Species
has only substance units: false
is: C00122
is: HMDB00134
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: Fumarate

metaR r0913
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110036#

metaR SUCCTD
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR r1540
modifier: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000185
is described by: ECO:0000000
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
reversible: false
reactant: MODEL1310110036#

metaM dcsptn1coa m
has only substance units: false
is: C16173
constant: false
is: HMDB06513
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205483
type: Species
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial concentration: 1.0

metaM dutp m
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:17625
initial amount: NaN
has only substance units: false
name: dUTP
is: HMDB01191
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247

metaM succ c
is: C00042
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species
name: Succinate
initial concentration: 1.0
has only substance units: false
is: HMDB00254
is: SBO:0000247
constant: false
is: CHEBI:30031

metaR r1651
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR PPDOy
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110036#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110036#
modifier: MODEL1310110036#

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR PSt3
is described by: ECO:0000269
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
name: phosphatidylserine transport
kinetic law: MODEL1310110036#
type: Reaction
reversible: true

metaR r2378
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_54a8146a_abdc_45bd_a05b_64a167eece5c
is encoded by: hsa:6515
initial amount: NaN
name: SLC2A3
is: P11169
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaM HC02205 e
is: CHEBI:28099
initial amount: NaN
name: prostaglandin-b2
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
type: Species
is: SBO:0000247

metaR GLYCt
name: glycerol transport via channel
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
reactant: MODEL1310110036#
fast: false
product: MODEL1310110036#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_0c65d9f1_7f96_4e9b_b401_214f3886ac34
boundary condition: true
name: ACP5
type: Species
has only substance units: false
is: P13686
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54

metaR r2389
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#

metaM tyr L e
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: HMDB00158
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:17895
name: L-tyrosine
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f6a119ef_dca8_447f_898c_d2b34ef3ad29
type: Species
is encoded by: hsa:8694
boundary condition: true
initial concentration: NaN
name: DGAT1
initial amount: NaN
is: O75907
constant: false
has only substance units: false
is: SBO:0000252

metaM pro D c
initial concentration: 1.0
name: D-proline
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: CHEBI:16313
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB03411
constant: false

metaM 5dpmev x
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: (R)-5-Diphosphomevalonate
is: HMDB01090
has only substance units: false
is: CHEBI:15899
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
constant: false

metaM 56dthm c
initial amount: NaN
name: 5,6-dihydrothymine
is: CHEBI:27468
is: HMDB00079
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906

metaM asp L c
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species
name: L-aspartate(1-)
is: SBO:0000247
initial amount: NaN
is: HMDB00191
initial concentration: 1.0
is: CHEBI:29991

metaM phe L c
is: CHEBI:17295
has only substance units: false
boundary condition: false
name: L-phenylalanine
is: HMDB00159
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
type: Species
is: SBO:0000247
initial amount: NaN

metaR r0166
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
reactant: MODEL1310110036#
type: Reaction
reversible: false
product: MODEL1310110036#
is: SBO:0000176
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19

http://identifiers.org/biomodels.db/MODEL1310110036#_6cb78663_f277_4c40_a0b2_174a444c987f
name: ELOVL4
type: Species
is encoded by: hsa:6785
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9GZR5
boundary condition: true
constant: false
initial concentration: NaN

metaR r1650
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_d33cfa2e_1ef3_4f11_b96b_766ece93f5e6
boundary condition: true
is encoded by: hsa:U52111
name: _U52111_1_c
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_e9cef403_0d9f_46d6_b3b9_9060c5cad66b
type: Species
initial amount: NaN
boundary condition: true
name: _AA021081_1_r
is encoded by: hsa:AA021081
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR RE0344C
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
fast: false
name: RE0344
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_76f8c400_2439_4691_a70a_3aa7d5eb1c85
is: E7EML0
name: SLC4A8
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:9498
constant: false
is: SBO:0000252
has only substance units: false
type: Species

metaR r0408
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
is: SBO:0000176
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
type: Reaction
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110036#
reversible: true
is described by: ECO:0000000

metaM q10h2 e
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial amount: NaN
is: HMDB13111
name: Ubiquinol-10
type: Species

metaR r2377
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185

metaR r0915
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110036#

metaR ALAtN1
type: Reaction
modifier: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
kinetic law: MODEL1310110036#
name: Alanine transport (Na, H coupled)
reactant: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_5bf71927_e491_4723_826f_b15b5f254f16
is encoded by: hsa:6581
initial concentration: NaN
is: Q5SYN6
constant: false
name: SLC22A3
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM C05279 m
constant: false
is: CHEBI:28387
name: trans,cis-Lauro-2,6-dienoyl-CoA
type: Species
initial concentration: 1.0
is: HMDB11123
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR GCCcm
reversible: true
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110036#
fast: false
name: glycine-cleavage complex (lipoylprotein), mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110036#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_ae84a5d6_87c0_4911_8a46_cec9f8b76d14
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: ACP1
has only substance units: false
type: Species
is: Q59EH3
is encoded by: hsa:52

metaM dd2coa m
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03712
constant: false
is: CHEBI:57330
type: Species
is: SBO:0000247
name: trans-dodec-2-enoyl-CoA(4-)
boundary condition: false

metaR TCYNTtm
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is described by: ECO:0000000
product: MODEL1310110036#
is: SBO:0000185
name: Thiocyanate transport via diffusion (mitochondrial)
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_a7b9da1f_d42a_4e2f_a2dd_582cf4f7beca
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AI222095
name: _AI222095_1_e
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM hista c
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
initial amount: NaN
initial concentration: 1.0
is: HMDB00870
has only substance units: false
name: histamium
constant: false
is: SBO:0000247
type: Species
is: CHEBI:58432
boundary condition: false

metaR GLYSARCNc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaR AHCYStr
type: Reaction
is: SBO:0000185
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110036#
name: S-Adenosyl-L-homocysteine intracellular diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ

metaM HC02205 c
type: Species
constant: false
is: SBO:0000247
is: CHEBI:28099
initial amount: NaN
has only substance units: false
boundary condition: false
name: prostaglandin-b2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

metaR r0407
is: SBO:0000176
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.4.3.5
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110036#

metaR TRDR
fast: false
is described by: ECO:0000269
product: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
name: thioredoxin reductase (NADPH)

metaM nadh m
initial amount: NaN
constant: false
is: C00004
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
is: CHEBI:57945

metaM asp L e
is: HMDB00191
constant: false
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
is: CHEBI:29991
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM zymstnl r
constant: false
is: CHEBI:16608
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: HMDB06841
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
name: 5alpha-cholest-8-en-3beta-ol

metaR DADNt4
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
name: deoxyadenosine transport via diffusion

metaM phe L e
has only substance units: false
is: HMDB00159
constant: false
boundary condition: false
name: L-phenylalanine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:17295
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079

http://identifiers.org/biomodels.db/MODEL1310110036#_20041e56_54d3_4f05_9e8f_edfdf338b216
is: Q5JT09
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:83549
boundary condition: true
initial amount: NaN
type: Species
name: UCK1

metaR r0051
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
modifier: MODEL1310110036#
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#

metaR r0885
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_d88f2973_70b9_43f2_a17e_7a80772292c1
is: P47989
initial amount: NaN
is encoded by: hsa:7498
name: XDH
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaM arach c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:32360
is: HMDB02212
constant: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
name: arachidate
has only substance units: false
type: Species

metaM dutp n
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB01191
is: SBO:0000247
is: CHEBI:17625
constant: false
boundary condition: false

metaR r2379
is described by: ECO:0000000
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110036#

metaR DM pnto R
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for (R)-Pantothenate
type: Reaction

metaR TRIODTHYt2
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
name: T3 transport via facilitated diffusion
fast: false
is described by: ECO:0000269
reversible: true

metaR r0917
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
type: Reaction

metaR DCTPtn
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
name: dCTP diffusion in nucleus
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM dttp e
name: dTTP(4-)
is: HMDB01342
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
is: CHEBI:37568
has only substance units: false
initial amount: NaN

metaM bilglcur r
has only substance units: false
is: CHEBI:57767
initial concentration: 1.0
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_f2d58489_0054_421d_a21f_a52d29a40828
is encoded by: hsa:728226
initial concentration: NaN
type: Species
name: _728226_1_m
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM dd2coa x
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57330
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial amount: NaN
is: HMDB03712
name: trans-Dodec-2-enoyl-CoA

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR COAtm
reversible: true
product: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
fast: false
name: CoA transporter
type: Reaction

metaR RNDR1
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (ADP)
reactant: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110036#
reversible: false

metaR OCCOAtm
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: Octanoyl-CoA transport, diffusion

http://identifiers.org/biomodels.db/MODEL1310110036#_c04d21fc_d7c5_4797_8242_b0694a31ac1c
initial amount: NaN
is: Q53H96
is encoded by: hsa:65263
name: PYCRL
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r2385
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM urate e
initial amount: NaN
is: HMDB00289
is: SBO:0000247
name: Urate
type: Species
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
has only substance units: false
is: CHEBI:17775
initial concentration: 1.0
boundary condition: false
constant: false

metaR PCHOL HSter
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
product: MODEL1310110036#
type: Reaction
reversible: true
name: phosphatidylcholine scramblase

metaR r2374
product: MODEL1310110036#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_d797c0e8_dbb6_4e17_b5dd_1f0e27b4b6c9
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P15531
name: NME1
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:4830

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_79bbe11b_0933_4232_b275_a41487b5dc9c
type: Species
name: SLCO1B1
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q9Y6L6
is encoded by: hsa:10599
is: SBO:0000252
initial amount: NaN
constant: false

metaR r0399
is: SBO:0000176
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
reactant: MODEL1310110036#
reversible: true
is described by: ECO:0000000
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
type: Reaction

metaR r1431
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110036#
reversible: false
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#

metaM thyox L c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247
initial amount: NaN
is: HMDB00248
name: L-thyroxine
is: CHEBI:18332
type: Species
constant: false
has only substance units: false

metaR ADPtx
type: Reaction
name: ADP transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000185
reversible: true
reactant: MODEL1310110036#

metaR ALCD21 L
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.99.24
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
name: alcohol dehydrogenase (L-1,2-propanediol)
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
reversible: false
product: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_cfc14798_e31d_4005_9caf_c2588ba329e5
name: DLD:DLST:OGDH:PDHX
boundary condition: true
has part: B4E3E9
type: Species
initial amount: NaN
is encoded by: hsa:4967
initial concentration: NaN
has only substance units: false
is: SBO:0000297
constant: false

metaR ABUTt2r
name: 4-aminobutyrate reversible transport in via proton symport
kinetic law: MODEL1310110036#
is: SBO:0000185
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
fast: false
is described by: ECO:0000304
modifier: MODEL1310110036#
reversible: true

metaR r2028
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_490d6638_f0b6_461e_9f13_9c1e12e5f532
initial amount: NaN
type: Species
boundary condition: true
is: G3XA95
is encoded by: hsa:8611
is: SBO:0000252
constant: false
name: PPAP2A
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_fd1dd7e2_db0d_42d6_b9fe_eb3f4d43a921
is encoded by: hsa:8803
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: E5KS60
name: SUCLA2
constant: false
initial amount: NaN

metaR r2373
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
fast: false
is: SBO:0000185
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_574c467b_dccd_4984_9b2a_708dc5a99375
is: P15121
initial concentration: NaN
is encoded by: hsa:231
type: Species
name: AKR1B1
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

metaM dttp c
is: CHEBI:37568
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
is: C00459
boundary condition: false
name: dTTP
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: HMDB01342
has only substance units: false

metaM ocdca e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: C01530
is: CHEBI:25629
name: octadecanoate (n-C18:0)
boundary condition: false
is: HMDB00827
constant: false
has only substance units: false
type: Species
is: SBO:0000247

metaR CYTK12n
modifier: MODEL1310110036#
is: SBO:0000176
name: cytidylate kinase (dCMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true
is described by: ECO:0000269
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM HC01434 c
is: SBO:0000247
initial concentration: 1.0
name: oxalatosuccinate(3-)
constant: false
has only substance units: false
is: CHEBI:58931
type: Species
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN

metaR r2386
modifier: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: false
product: MODEL1310110036#

metaR r0517
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
modifier: MODEL1310110036#
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1

metaR r0722
modifier: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110036#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.3.12
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_32f3a1bf_402c_4953_a12a_6e95b2e897fe
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:8310
name: ACOX3
initial amount: NaN
type: Species
is: O15254
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_b42b9124_9cb1_4f6e_bee3_9f0fe0cac5b8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7372
boundary condition: true
type: Species
name: UMPS
constant: false
is: A8K5J1
initial amount: NaN

metaM dcsptn1coa x
is: C16173
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
constant: false
is: HMDB06513
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN

metaM 3m4hpga c
type: Species
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
boundary condition: false
constant: false
is: C05583
has only substance units: false
is: http://identifiers.org/pubchem.compound/7909
initial amount: NaN
initial concentration: 1.0
is: HMDB04061
is: SBO:0000247

metaR MMMm
reversible: true
is: SBO:0000176
product: MODEL1310110036#
type: Reaction
name: methylmalonyl-CoA mutase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.4.99.2
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
fast: false
reactant: MODEL1310110036#

metaR RNDR3
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
name: ribonucleoside-diphosphate reductase (CDP)
modifier: MODEL1310110036#
reversible: false
product: MODEL1310110036#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
fast: false
type: Reaction

metaM nadp e
initial amount: NaN
is: CHEBI:58349
type: Species
boundary condition: false
initial concentration: 1.0
name: NADP+(3-)
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 INCHI: InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p-3/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: HMDB00217
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d122fb8b_7406_4d03_a2f4_78b70d76f71a
is encoded by: hsa:6821
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SUOX
constant: false
is: P51687
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_6d09777e_2fce_4951_a4dd_9042a7b21c82
type: Species
has only substance units: false
is: SBO:0000252
name: NME4
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: O00746
is encoded by: hsa:4833

http://identifiers.org/biomodels.db/MODEL1310110036#_8eca6876_715d_447f_9e1a_52e378197b31
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: HEXA
initial amount: NaN
is: P06865
is encoded by: hsa:3073
initial concentration: NaN

metaR AHCYSte
reactant: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
fast: false
name: Transport of S-adenosyl-L-homocysteine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134

metaM ser L m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
is: HMDB00187
constant: false
initial amount: NaN
boundary condition: false
type: Species

metaM glyc3p c
is: HMDB00126
initial amount: NaN
constant: false
is: C00093
has only substance units: false
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_c7abc53b_b691_4713_86f2_a7220d50c4bb
boundary condition: true
name: NME2
is: P22392
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:4831
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_e1225439_055d_482d_9551_eaa8cd60bba0
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: GCDH
boundary condition: true
is encoded by: hsa:2639
has only substance units: false
constant: false
is: Q92947

metaR r0723
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
reversible: false
product: MODEL1310110036#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110036#

metaR LEUKTRF4t
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185
name: leukotriene F4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false

metaR r2376
product: MODEL1310110036#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110036#
fast: false

metaR r0669
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reversible: false
product: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:

metaM tyr L c
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00158
initial amount: NaN
has only substance units: false
constant: false
name: L-tyrosine
initial concentration: 1.0

metaR r2387
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
reversible: false
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_72989d68_da77_4757_9558_13dbc4183e26
is: SBO:0000252
initial concentration: NaN
is: O75747
type: Species
name: PIK3C2G
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5288

metaM 3pg m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: CHEBI:58272
has only substance units: false
is: HMDB00807
constant: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: SBO:0000247
type: Species

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_d34d6f0e_9193_4600_8eba_628f0652aca4
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:3295
is: E9PB82
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: HSD17B4

metaR PIPLC
kinetic law: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
name: phosphatidylinositol phospholipase C

metaR DNDPt10m
fast: false
reversible: false
name: dADP transport via dCDP antiport
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000269

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
fast: false
name: RE0944
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110036#_b94233cc_83ec_43a1_9966_438146ebdfb4
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:55
has only substance units: false
is: P15309
boundary condition: true
name: ACPP
is: SBO:0000252

metaM 13 cis retn r
type: Species
is: D00348
initial concentration: 1.0
boundary condition: false
is: HMDB06219
has only substance units: false
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7847414
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_51e189d7_6846_4915_bb58_4d001d725b5f
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: SLC16A8
initial concentration: NaN
is encoded by: hsa:23539
initial amount: NaN
has only substance units: false
is: O95907

metaR r1433
kinetic law: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
reversible: false
fast: false
product: MODEL1310110036#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is described by: ECO:0000000

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_164a6d62_3f3c_4eaf_af7d_a9b11319496f
constant: false
is encoded by: hsa:7389
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P06132
name: UROD
has only substance units: false

metaM ocdca c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:25629
boundary condition: false
has only substance units: false
is: HMDB00827
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
type: Species
name: stearate
constant: false

metaR GGH 7DHFe
fast: false
is: SBO:0000176
name: Gamma-glutamyl hydrolase (7DHF), extracellular
kinetic law: MODEL1310110036#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000

metaR COAtn
fast: false
name: coenzyme A transport, nuclear
product: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_02d1a52d_ecb8_4879_a013_28717a526b3f
name: NME3
boundary condition: true
type: Species
is: Q13232
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4832
initial concentration: NaN

metaM nadp c
boundary condition: false
is: HMDB00217
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
constant: false
is: CHEBI:58349
type: Species

metaR r2026
product: MODEL1310110036#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_77c4a2f6_41ec_4179_863e_6083c322a557
boundary condition: true
constant: false
is encoded by: hsa:5293
initial amount: NaN
is: SBO:0000252
is: A7E2E0
type: Species
has only substance units: false
name: PIK3CD
initial concentration: NaN

metaR r0668
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is: SBO:0000176
type: Reaction
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.19
modifier: MODEL1310110036#
reversible: true
fast: false
reactant: MODEL1310110036#

metaR r2375
kinetic law: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110036#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR GLYt2r
type: Reaction
modifier: MODEL1310110036#
is described by: ECO:0000304
name: glycine reversible transport via proton symport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#

metaR r0724
type: Reaction
reversible: true
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
fast: false
reactant: MODEL1310110036#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_6e16d172_6e74_413d_82eb_8c577bf3977f
boundary condition: true
name: UGCG
has only substance units: false
is: Q16739
initial amount: NaN
is encoded by: hsa:7357
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_4b0b3ebc_7c3b_4c07_b251_a7252ca5a221
constant: false
initial concentration: NaN
name: ALDH7A1
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:501
type: Species
is: E7EPT3
has only substance units: false

metaM q10h2 c
initial concentration: 1.0
constant: false
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN
is: HMDB13111
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaR r2388
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
product: MODEL1310110036#

metaM nmn c
constant: false
is: C00455
is: SBO:0000247
is: CHEBI:14649
type: Species
name: NMN
initial amount: NaN
is: HMDB00229
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_9488d2aa_6a37_4379_a800_5b7523feb5a4
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:T83654
name: _T83654_1_m
constant: false
has only substance units: false
boundary condition: true

metaR r0160
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.1.3.2
is: SBO:0000176
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
reactant: MODEL1310110036#
reversible: false
is described by: ECO:0000000
product: MODEL1310110036#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
type: Reaction

metaR r0881
name: Active transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
reversible: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

metaR r0055
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
kinetic law: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.7
fast: false
is: SBO:0000176
reactant: MODEL1310110036#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
product: MODEL1310110036#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110036#

metaR CYSTS
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD
is: SBO:0000176
reversible: false
name: cystathionine beta-synthase
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.22
kinetic law: MODEL1310110036#

metaR r1659
fast: false
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110036#_977fdfe5_5833_461f_9a65_247eb966d6a8
constant: false
boundary condition: true
is: P21399
is: SBO:0000252
is encoded by: hsa:48
name: ACO1
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM acac c
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:13705
constant: false
name: acetoacetate
has only substance units: false
is: HMDB00060

metaR r0308
reactant: MODEL1310110036#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110036#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
fast: false
product: MODEL1310110036#

metaR UDPGLCter
reactant: MODEL1310110036#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110036#

metaR RETI1
product: MODEL1310110036#
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110036#
name: retinol isomerase (11-cis)
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction

metaR UREAt
reversible: true
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR
name: Urea transport via facilitate diffusion
type: Reaction
product: MODEL1310110036#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_4b8a9d41_023e_4862_b427_031dd0a6eb0c
constant: false
is encoded by: hsa:1119
name: CHKA
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r1548
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
reactant: MODEL1310110036#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaR RE3245C
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
name: RE3245
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
fast: false
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_5d026318_179d_44e4_a06f_89b06e6bd8b6
initial amount: NaN
boundary condition: true
constant: false
is: Q7Z725
is encoded by: hsa:6569
name: SLC34A1
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaR DHFR
product: MODEL1310110036#
is described by: ECO:0000254
name: dihydrofolate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
reversible: true
modifier: MODEL1310110036#
type: Reaction

metaR O2St
name: superoxide anion transport via diffusion (extracellular)
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110036#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#

metaM thf c
is: CHEBI:57453
initial concentration: 1.0
is: HMDB01846
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
name: 5,6,7,8-Tetrahydrofolate
boundary condition: false
is: C00101
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_0166e9a0_3227_4cba_8c42_0c8807711261
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ZADH2
is encoded by: hsa:284273
boundary condition: true
type: Species
is: Q8N4Q0
constant: false

metaR r1435
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110036#
is: SBO:0000185
name: Transport reaction
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_41c9b125_8f50_4d29_b175_cad0210f7c60
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5538
is: Q6FGQ4
is: SBO:0000252
name: PPT1
constant: false

metaM nadh c
is: HMDB01487
constant: false
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00004
has only substance units: false
boundary condition: false
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_35e182f1_67ea_475e_8711_8254d3f2e352
constant: false
name: SLC24A4
is: Q8NFF2
is encoded by: hsa:123041
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN

metaM cdp e
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:58069
is: HMDB01546
initial concentration: 1.0
constant: false
name: CDP(3-)
has only substance units: false
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

http://identifiers.org/biomodels.db/MODEL1310110036#_f9ff4d30_c70a_4fc3_84c5_c373a8e176b9
initial amount: NaN
name: PANK4
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: Q9NVE7
is: SBO:0000252
is encoded by: hsa:55229

metaR r0726
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.33
reversible: true
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110036#
is described by: ECO:0000000

metaR COAtp
kinetic law: MODEL1310110036#
name: coenzyme A transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110036#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110036#

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#
reversible: true
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110036#

metaR 2OXOADOXm
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.61
reversible: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is: SBO:0000176
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
reactant: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_3d2310f1_c407_4f79_8d2a_562a2ff4a6d1
is: SBO:0000252
initial amount: NaN
constant: false
is: Q15181
boundary condition: true
name: PPA1
initial concentration: NaN
is encoded by: hsa:5464
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_c7ea4e5e_f15b_4b3f_9137_1d56e3fce942
is encoded by: hsa:4718
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: NDUFC2
is: Q549M5
is: SBO:0000252

metaR RETI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
reactant: MODEL1310110036#
name: retinol isomerase (9-cis)
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: true
fast: false
product: MODEL1310110036#

metaR r0666
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110036#
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is version of: http://identifiers.org/ec-code/1.2.4.2
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
reversible: true
is: SBO:0000176

metaM chsterol l
name: cholesterol
is: CHEBI:16113
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: SBO:0000247
type: Species
is: HMDB00067
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR r1547
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false

metaR r2382
kinetic law: MODEL1310110036#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
modifier: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
fast: false
reactant: MODEL1310110036#

metaM ethamp r
boundary condition: false
has only substance units: false
type: Species
is: HMDB00224
is: CHEBI:58190
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
name: O-phosphonatoethanaminium(1-)
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR SRTNt6 2 r
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
fast: false
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185

metaM mi3p D c
is: CHEBI:58401
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
boundary condition: false
constant: false
is: HMDB06814
has only substance units: false
initial concentration: 1.0
name: 1D-myo-inositol 3-phosphate(2-)
is: SBO:0000247
type: Species
initial amount: NaN

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
fast: false
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110036#_2ad7cb18_1d6e_4559_ad81_546c7a10e58b
boundary condition: true
constant: false
initial amount: NaN
name: NOS3
is: SBO:0000252
is encoded by: hsa:4846
has only substance units: false
type: Species
is: A0S0A7
initial concentration: NaN

metaR r1434
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction
product: MODEL1310110036#
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
reactant: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_2ac8e407_0f0f_4625_9893_7b94f17dc45e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:221
type: Species
is: P43353
initial amount: NaN
has only substance units: false
constant: false
name: ALDH3B1
initial concentration: NaN

metaM glysar c
notes: FORMULA: C5H10N2O3 CHARGE: 0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: Glycylsarcosine
is: SBO:0000247
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/93131

metaM urate c
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00289
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
type: Species
is: CHEBI:17775
is: C00366
name: Urate

metaR r1657
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#

metaM acac e
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
has only substance units: false
is: CHEBI:13705
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: acetoacetate
is: HMDB00060

metaR FACOAL180i
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
type: Reaction
reactant: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
name: C180 fatty acid activation
is described by: ECO:0000269
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#

metaM 3hpp m
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:16510
name: 3-hydroxypropionate
boundary condition: false
is: HMDB00700

metaM s7p c
is: C05382
initial amount: NaN
is: CHEBI:57483
name: Sedoheptulose 7-phosphate
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01068
has only substance units: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
boundary condition: false
constant: false

metaM q10 c
name: ubiquinone-10
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB01072
constant: false
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
initial amount: NaN

metaR r2372
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM chsterol m
type: Species
name: cholesterol
is: CHEBI:16113
initial amount: NaN
is: HMDB00067
has only substance units: false
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR r0393
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_001c4942_b9ba_435a_a177_8f98c417e90f
is: Q5QPH3
constant: false
has only substance units: false
name: ACSS2
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:55902
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_6ae58c98_cbd3_4054_a528_a2a47556513b
constant: false
name: _AA629629_1_m
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA629629
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

metaM thf e
is: HMDB01846
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453

metaM cdp c
has only substance units: false
constant: false
name: CDP
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58069
is: C00112
is: HMDB01546
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species

metaR RNDR4
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (UDP)
kinetic law: MODEL1310110036#
reversible: false
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
fast: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.17.4.1

metaM bhb c
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial amount: NaN
is: HMDB00011
is: SBO:0000247
is: CHEBI:10983
boundary condition: false
name: (R)-3-hydroxybutyrate
type: Species

metaR DHCR72r
modifier: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#
name: 7-dehydrocholesterol reductase
reversible: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.1.21
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_206e208a_799a_4f5d_b374_97a48991aa47
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O14735
has only substance units: false
is encoded by: hsa:10423
type: Species
name: CDIPT
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_51ee52b2_6f95_4ab8_b6ab_0b4da7386cfe
name: PDHX
is: SBO:0000252
boundary condition: true
is: O00330
initial amount: NaN
type: Species
is encoded by: hsa:8050
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_b5101567_1f39_44b0_99ae_212a8a7a7b3f
is encoded by: hsa:4705
is: O95299
boundary condition: true
name: NDUFA10
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR GGH 10FTHF5GLUe
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
is: SBO:0000176
reversible: false

metaR r0728
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction

metaR r1656
modifier: MODEL1310110036#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR COAtr
product: MODEL1310110036#
name: COA transporter, endoplasmic reticulum
reactant: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110036#_e9bef415_fbe1_4288_94b6_8e7682471da6
initial amount: NaN
has only substance units: false
constant: false
name: HAO2
type: Species
is encoded by: hsa:51179
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r2384
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110036#
reversible: false
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#

metaR RE1573M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000000
product: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
type: Reaction
name: RE1573

metaR r1549
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185

metaR r2371
is: SBO:0000185
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
fast: false

metaM zym int2 r
initial concentration: 1.0
type: Species
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
boundary condition: false
constant: false
name: zymosterol intermediate 2
has only substance units: false
is: CHEBI:52386
initial amount: NaN
is: SBO:0000247

metaR r0281
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/5.3.1.6
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110036#

metaR G5SADrm
is: SBO:0000176
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_cfe0bb4e_8b04_43db_ab0d_8dff5ed286ce
name: VNN3
is: SBO:0000252
is encoded by: hsa:55350
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaM glysar e
notes: FORMULA: C5H10N2O3 CHARGE: 0
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/93131
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Glycylsarcosine
type: Species

metaR r0394
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000176
product: MODEL1310110036#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110036#
fast: false

metaM 34dhmald c
is: http://identifiers.org/pubchem.compound/7903
type: Species
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false
is: C05577
name: 3,4-Dihydroxymandelaldehyde
is: HMDB06242
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR RE2973C
kinetic law: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110036#
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is: SBO:0000176
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.137
fast: false
name: RE2973
type: Reaction

metaR CYANt
reversible: true
reactant: MODEL1310110036#
name: Cyanide transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110036#

metaM lac D e
is: CHEBI:16004
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: HMDB01311
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
has only substance units: false
is: SBO:0000247
name: (R)-lactate
boundary condition: false

metaM dgchol c
type: Species
is: CHEBI:36252
is: HMDB00637
is: SBO:0000247
constant: false
initial amount: NaN
name: glycochenodeoxycholate
boundary condition: false
has only substance units: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0

metaM 3mob c
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
initial concentration: 1.0
is: CHEBI:11851
initial amount: NaN
is: HMDB00019
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: 3-methyl-2-oxobutanoate

metaR r0531
modifier: MODEL1310110036#
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reactant: MODEL1310110036#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.34
fast: false

metaR TCHOLAte
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
product: MODEL1310110036#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185

metaR HACD9m
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
product: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000134
reactant: MODEL1310110036#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000176

metaM frdp c
is: CHEBI:175763
boundary condition: false
is: HMDB00961
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: Farnesyl diphosphate
initial amount: NaN
constant: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: C00448

http://identifiers.org/biomodels.db/MODEL1310110036#_205f814c_cd48_4faa_b8ac_29599682d522
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4191
initial concentration: NaN
name: MDH2
constant: false
is: SBO:0000252
is: P40926

metaM 1pyr5c m
initial concentration: 1.0
constant: false
is: CHEBI:15893
boundary condition: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
type: Species
is: HMDB01301
initial amount: NaN
is: SBO:0000247
name: 1-Pyrroline-5-carboxylate
is: C03912
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_22a8d281_d6d9_49de_9e4b_c4efa76ec4d6
type: Species
is: SBO:0000252
name: NMNAT2
is encoded by: hsa:23057
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_58c29300_2f89_410b_814f_60a0c0c083b1
is encoded by: hsa:1349
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P24311
name: COX7B
boundary condition: true

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR ADNt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reversible: true
reactant: MODEL1310110036#
name: adenosine facilated transport in cytosol
kinetic law: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000269
modifier: MODEL1310110036#

metaR GLNS
is version of: http://identifiers.org/ec-code/4.1.1.15
reversible: false
modifier: MODEL1310110036#
fast: false
name: glutamine synthetase
type: Reaction
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_371fe968_cb4f_4512_a104_5d1788fead30
type: Species
initial concentration: NaN
name: _U37519_1_m
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:U37519
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_799ac476_e3fb_464a_b2e2_22776e7ab800
boundary condition: true
name: LHPP
initial concentration: NaN
is: Q9H008
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:64077
is: SBO:0000252

metaR ARABR
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.2
name: arabinose reductase
fast: false
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:

metaR DURAD
kinetic law: MODEL1310110036#
is described by: ECO:0000269
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.1.2
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
fast: false
reversible: true
product: MODEL1310110036#
type: Reaction
name: dihydrouracil dehydrogenase (NADP)
reactant: MODEL1310110036#
is: SBO:0000176

metaR LEUPHELAT2tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR SPMTDe
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110036#
reversible: true
name: SPMTDe
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#

metaR INSt4
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
reversible: false
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110036#
name: inosine transport in via sodium symport
notes: GENE_ASSOCIATION: (9153.1) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110036#_343bf436_8cf9_4078_9a85_291b2ed5e93c
name: NDUFB4
is: O95168
is: SBO:0000252
is encoded by: hsa:4710
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_bd31ef52_5745_4543_b5dd_bad2ed7a9f89
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9990
name: SLC12A6
boundary condition: true
is: Q9UHW9
is: SBO:0000252
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_b4affaf1_83cc_4deb_b421_a734e5f86b0e
initial concentration: NaN
has only substance units: false
name: ACAT1
is encoded by: hsa:38
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is: P24752
boundary condition: true

metaM focytC m
constant: false
is: CHEBI:16928
is: SBO:0000247
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: Ferrocytochrome C

http://identifiers.org/biomodels.db/MODEL1310110036#_ba260c9f_120d_4c9e_800a_9630d95699db
is: SBO:0000252
boundary condition: true
constant: false
name: MTMR3
type: Species
is encoded by: hsa:8897
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM thp2c c
is: CHEBI:16987
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
type: Species
constant: false
name: 1-piperideine-6-carboxylate
is: SBO:0000247
is: HMDB12130
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d3152084_62b4_432c_8d0d_ae71832f002b
name: LDHB
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: P07195
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3945
initial amount: NaN

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaM lac D c
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial amount: NaN
name: (R)-lactate
boundary condition: false
is: SBO:0000247
is: HMDB01311
is: CHEBI:16004
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_acb21bcc_f066_4e9d_a3ff_c3777b7311bc
name: _AI620219_1_m
is encoded by: hsa:AI620219
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

metaR RETHe
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
name: retinyl ester hydrolase, extracellular
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_5465434b_df01_4eb9_b8cb_806784ef71bf
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1491
name: CTH
is: B4E1R2

metaR RE3567C
fast: false
name: RE3567
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaR SPHS1Ptr
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
reversible: true
name: sphingosine-1-phosphate transport
is: SBO:0000185
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_6ae5bd35_44e8_4486_a584_27fdeb2f51ff
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O14521
type: Species
constant: false
boundary condition: true
name: SDHD
is encoded by: hsa:6392

metaM r5p c
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
initial concentration: 1.0
is: C00117
has only substance units: false
name: alpha-D-Ribose 5-phosphate
initial amount: NaN
constant: false
is: CHEBI:18189
is: HMDB00618
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_981e1195_ed59_46a9_82dd_653fdb2c568a
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4831
is encoded by: hsa:4830
initial concentration: NaN
name: NME1:NME2
has part: P22392
has only substance units: false
constant: false
has part: P15531
is: SBO:0000297

metaR GLYSNAT5tc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM nadh x
constant: false
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
has only substance units: false
is: C00004
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_6544ab7f_81ac_403d_81e5_b4365074f4db
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84532
constant: false
boundary condition: true
is: SBO:0000252
name: ACSS1
initial amount: NaN
type: Species
is: Q9NUB1

metaM dcholcoa r
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB06292
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: chenodeoxycholoyl coenzyme a

metaR GLYCTDle
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000134
name: difussion of glycerol accross the brush border membrane
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#

metaR RE2659R
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2659
type: Reaction
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_6df1c30f_d4e7_428a_b003_fa848635a9f8
is encoded by: hsa:83715
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: ESPN
is: B1AK53
initial amount: NaN
type: Species
initial concentration: NaN

metaR PGLer
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
kinetic law: MODEL1310110036#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.47
product: MODEL1310110036#
name: 6-phosphogluconolactonase, endoplasmic reticulum
is: SBO:0000176
fast: false
modifier: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#

metaM tsul e
is: HMDB00257
has only substance units: false
initial amount: NaN
is: CHEBI:16094
constant: false
name: thiosulfate(2-)
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_1ffd9d33_aad9_4d49_b5b7_aaa3fa773e8d
constant: false
name: COX5B
is: Q53YB7
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1329

metaR ALCD21 D
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
reversible: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.99.24
reactant: MODEL1310110036#
is described by: ECO:0000304
name: alcohol dehydrogenase (D-1,2-propanediol)
modifier: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD

metaR RE2814R
product: MODEL1310110036#
reversible: true
name: RE2814
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_39d80351_3a07_4788_898e_2709059f4c86
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q6PCB7
initial concentration: NaN
is encoded by: hsa:376497
type: Species
name: SLC27A1
constant: false

metaR GLCt2 2
reversible: true
fast: false
product: MODEL1310110036#
name: D-glucose transport in via proton symport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_1da02896_a3ae_4b0d_b863_25de88cf469d
initial concentration: NaN
is: O75438
is encoded by: hsa:4707
is: SBO:0000252
initial amount: NaN
name: NDUFB1
type: Species
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_9de1c01b_0c6e_4e25_9e38_971ca0f391ff
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: _U37519_1_e
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:U37519

http://identifiers.org/biomodels.db/MODEL1310110036#_33de95eb_f877_4749_80bc_97f0f198cd90
is: P00390
is encoded by: hsa:2936
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: GSR
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_3e801351_86c2_4928_b301_9d10686d2f9c
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2712
constant: false
has only substance units: false
name: GK2
boundary condition: true
is: SBO:0000252
is: Q14410

metaM xol27oh r
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB02103
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
name: 26-hydroxycholesterol
constant: false
type: Species
is: CHEBI:17703

http://identifiers.org/biomodels.db/MODEL1310110036#_33cb64f4_aee7_4016_8a85_dcd558c32e04
type: Species
is: B7Z3W8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6536
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SLC6A9

http://identifiers.org/biomodels.db/MODEL1310110036#_6e29384b_c9eb_4b6b_91ec_79b18c5931a0
type: Species
is encoded by: hsa:2876
is: SBO:0000252
constant: false
boundary condition: true
name: GPX1
is: P07203
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR FAS180COA
is: SBO:0000176
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110036#
name: fatty-acyl-CoA synthase (n-C18:0CoA)
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110036#

metaR RE1523M
modifier: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1523
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110036#

metaR RE2814M
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: RE2814
fast: false
product: MODEL1310110036#
type: Reaction

metaR SBTR
name: D-sorbitol reductase
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000269
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
type: Reaction
reversible: false
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_fd1f5921_b4ff_4609_9347_3ed0efd21e05
is encoded by: hsa:3939
is: SBO:0000252
name: LDHA
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P00338
constant: false

metaR DGK1
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: deoxyguanylate kinase (dGMP:ATP)
is version of: http://identifiers.org/ec-code/2.7.4.8

metaR DPMVDx
modifier: MODEL1310110036#
is: SBO:0000176
reversible: false
reactant: MODEL1310110036#
is described by: ECO:0000134
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.1.1.33
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
type: Reaction
product: MODEL1310110036#
name: diphosphomevalonate decarboxylase

http://identifiers.org/biomodels.db/MODEL1310110036#_62b89244_db02_4d59_8603_5fa2fa61e3d1
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:3251
type: Species
name: HPRT1
is: P00492
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR G6PDH1rer
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.47
is: SBO:0000176
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
reversible: true
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
reactant: MODEL1310110036#

metaM crm hs r
is: CHEBI:52639
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_64359ff7_f39d_4714_a6db_2f84f62de84b
initial concentration: NaN
boundary condition: true
is encoded by: hsa:549
has only substance units: false
initial amount: NaN
constant: false
name: AUH
type: Species
is: SBO:0000252
is: Q13825

http://identifiers.org/biomodels.db/MODEL1310110036#_cad5db4b_cb11_4f73_b2ab_efbcda5389a1
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:NM 001929
is: SBO:0000252
initial amount: NaN
constant: false
name: _NM_001929_1_c

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR r1902
fast: false
product: MODEL1310110036#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110036#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110036#

metaR FATP1t
kinetic law: MODEL1310110036#
fast: false
product: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
type: Reaction
reversible: true
name: fatty acid electroneutral transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_a8d3d2d6_b1d4_42ea_9c31_73e5bdd9e199
initial amount: NaN
name: SLC7A10
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q9NS82
is encoded by: hsa:56301
type: Species

metaM c14dccoa x
is: C14143
is: SBO:0000247
is: HMDB04047
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
has only substance units: false
name: tetradecanedioylcoa
initial amount: NaN
type: Species

metaR FADtru
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
fast: false
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110036#
name: FAD transporter, endoplasmic reticulum
is: SBO:0000185

metaM nicrnt c
initial amount: NaN
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
type: Species
has only substance units: false
is: HMDB01132
initial concentration: 1.0
is: C01185
is: CHEBI:57502
is: SBO:0000247
name: Nicotinate D-ribonucleotide
boundary condition: false
constant: false

metaR SERGLNexR
name: L-Serine/Glutamine reversible exchange
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaM ctp e
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
is: HMDB00082

http://identifiers.org/biomodels.db/MODEL1310110036#_35acc589_b404_49a1_a994_ce39f932d4d2
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: LHPP
constant: false
is encoded by: hsa:64077
is: Q9H008

metaM tsul c
has only substance units: false
is: CHEBI:16094
name: thiosulfate(2-)
boundary condition: false
initial concentration: 1.0
is: HMDB00257
initial amount: NaN
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_df90f5a0_8b67_4a6e_aeac_496ed78a0b6d
constant: false
initial amount: NaN
type: Species
name: INPP1
initial concentration: NaN
is encoded by: hsa:3628
is: SBO:0000252
has only substance units: false
is: P49441
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_f9abc79a_856c_40f8_bf70_95b935813982
initial concentration: NaN
name: ACAD9
is: Q9H845
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:28976

http://identifiers.org/biomodels.db/MODEL1310110036#_10a5a54c_bcee_4cf3_9c76_f5ee2cabdbe9
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AF116616
boundary condition: true
name: _AF116616_1_m
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaM ala D c
is: CHEBI:15570
is: HMDB01310
is: SBO:0000247
initial amount: NaN
name: D-alanine
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1

metaR PRFGS
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
fast: false
product: MODEL1310110036#
name: phosphoribosylformylglycinamidine synthase
is: SBO:0000176
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269
reactant: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.3

metaM pep m
constant: false
name: Phosphoenolpyruvate
is: CHEBI:18021
is: HMDB00263
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
is: C00074
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_fae37d91_149b_4412_b103_46801368f569
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:51733
is: SBO:0000252
name: UPB1
initial amount: NaN
is: B3KNC1

http://identifiers.org/biomodels.db/MODEL1310110036#_ff3413ce_55fd_4ec3_8e77_fc50d9989286
has only substance units: false
name: _AA664770_1_m
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AA664770
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR GLCURtly
type: Reaction
modifier: MODEL1310110036#
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
kinetic law: MODEL1310110036#
name: glucuronate transport into lysososme
reactant: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#

metaR r1993
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#

metaR RE3005M
fast: false
is described by: ECO:0000000
name: RE3005
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
reactant: MODEL1310110036#

metaM 3mob e
boundary condition: false
name: 3-methyl-2-oxobutanoate
is: CHEBI:11851
initial amount: NaN
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
is: HMDB00019
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0

metaM mi145p c
type: Species
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01498
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: CHEBI:203600
initial concentration: 1.0
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)

metaM dgchol e
has only substance units: false
is: HMDB00637
constant: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial concentration: 1.0
is: CHEBI:36252
is: SBO:0000247
initial amount: NaN
name: glycochenodeoxycholate
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_6aecc9fe_0e18_4afd_ad56_a0c0021d3d7c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:65010
type: Species
boundary condition: true
name: SLC26A6
initial amount: NaN
is: Q548A7
constant: false
initial concentration: NaN

metaM CE4872 c
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: HMDB00127
initial amount: NaN
type: Species
is: CHEBI:15748
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
initial concentration: 1.0
boundary condition: false

metaR DUDPtn
is described by: ECO:0000000
reactant: MODEL1310110036#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110036#
reversible: true
name: dUDP nuclear transport
kinetic law: MODEL1310110036#
type: Reaction

metaR RE3626M
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
product: MODEL1310110036#
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: RE3626
modifier: MODEL1310110036#
reversible: false

metaR PPA
name: inorganic diphosphatase
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
modifier: MODEL1310110036#

metaM lnlncgcoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
constant: false
type: Species
is: HMDB06368
boundary condition: false
is: SBO:0000247
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110036#_144118d9_f94a_480a_872e_57d00802aff5
boundary condition: true
is: SBO:0000252
constant: false
is: P19440
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2678
has only substance units: false
type: Species
name: GGT1

metaR ACACt2
reversible: true
fast: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reactant: MODEL1310110036#
modifier: MODEL1310110036#
name: acetoacetate transport via proton symport
is described by: ECO:0000269

metaR CYOOm3
is: SBO:0000185
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.9.3.1
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
name: cytochrome c oxidase, mitochondrial Complex IV

metaR TDCHOLAtx
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
reactant: MODEL1310110036#
reversible: true
type: Reaction
kinetic law: MODEL1310110036#
fast: false

metaM gluside hs c
has only substance units: false
name: D-glucosyl-N-acylsphingosine
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:18368

metaM g6p c
initial amount: NaN
boundary condition: false
is: CHEBI:61548
constant: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: C00092
is: HMDB01401
name: D-Glucose 6-phosphate
has only substance units: false
initial concentration: 1.0
type: Species

metaM CE5121 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
initial amount: NaN
name: trans-3-decenoyl-CoA
constant: false
initial concentration: 1.0
is: CHEBI:57449
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

metaR r1994
reversible: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR DURIPP
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
name: deoxyuridine phosphorylase
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is: SBO:0000176
modifier: MODEL1310110036#
reversible: true

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_abc51945_bb4d_47b4_92c3_ed84cae6baf6
is encoded by: hsa:10568
name: SLC34A2
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: O95436
constant: false
type: Species
initial concentration: NaN
boundary condition: true

metaM mmcoa S m
initial concentration: 1.0
type: Species
is: CHEBI:57327
is: HMDB02310
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
initial amount: NaN
name: (S)-methylmalonyl-CoA(5-)

http://identifiers.org/biomodels.db/MODEL1310110036#_42a05752_c59b_46d9_9b19_c1b917641eb6
constant: false
initial concentration: NaN
name: _AA532636_1_m
is encoded by: hsa:AA532636
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_95950891_b9f9_44e3_b529_b2f9f785d751
boundary condition: true
is encoded by: hsa:23533
type: Species
name: PIK3R5
constant: false
is: Q8WYR1
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM so3 c
initial amount: NaN
is: HMDB00240
has only substance units: false
is: C00094
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
name: Sulfite
boundary condition: false
is: CHEBI:17137

metaM ala D e
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01310
name: D-alanine
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
initial concentration: 1.0
is: CHEBI:15570
constant: false

metaR r1088
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#

metaR NDPK2n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
product: MODEL1310110036#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000269
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110036#
reversible: true

metaM xol27oh m
is: HMDB02103
constant: false
name: 26-hydroxycholesterol
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:17703

metaR NDPK2m
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
name: nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000254
kinetic law: MODEL1310110036#

metaR RTOTAL3FATPc
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaM crm hs e
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:52639

http://identifiers.org/biomodels.db/MODEL1310110036#_e69e7940_ae5d_4174_9615_29629b88b00a
is: Q9BV79
initial amount: NaN
has only substance units: false
name: MECR
constant: false
is: SBO:0000252
is encoded by: hsa:51102
type: Species
initial concentration: NaN
boundary condition: true

metaM HC02203 e
constant: false
initial concentration: 1.0
is: CHEBI:27820
name: prostaglandin-a2
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247

metaR r0426
is version of: http://identifiers.org/ec-code/1.5.1.34
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
fast: false
reactant: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000176

metaR GTHRDt
fast: false
reactant: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
product: MODEL1310110036#
is described by: ECO:0000000
reversible: true
type: Reaction
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110036#

metaM accoa c
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01206
is: C00024
has only substance units: false
is: SBO:0000247
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: CHEBI:57288

metaM nadh r
initial amount: NaN
is: HMDB01487
has only substance units: false
constant: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: CHEBI:57945
name: NADH(2-)
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

metaM 6dhf e
name: hexaglutamyl folate (DHF)
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB06563

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_65590066_3e34_4ebf_ab06_84354d23786e
constant: false
is: SBO:0000252
name: ALDH1B1
is encoded by: hsa:219
boundary condition: true
type: Species
is: P30837
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM HC00319 c
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:30794
boundary condition: false
name: Malonate
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_b3761af4_413e_4b89_9635_9fcfebfd35ee
initial concentration: NaN
name: _AA854479_1_m
initial amount: NaN
is encoded by: hsa:AA854479
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR r2508
fast: false
reversible: true
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#

metaR FAOXC121C10x
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaM g6p r
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: SBO:0000247
boundary condition: false
is: HMDB01401
is: CHEBI:61548
is: C00092
name: D-Glucose 6-phosphate
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_53a4901f_2087_4444_8a02_6d8a76a2aaee
is: SBO:0000252
constant: false
name: ACHE
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:43
type: Species
boundary condition: true

metaM Lpipecol x
is: HMDB00716
boundary condition: false
is: CHEBI:30913
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
name: L-pipecolic acid
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_da940f12_4d60_49c1_857b_dcd5cee976f3
boundary condition: true
name: ALDH3A2
has only substance units: false
is encoded by: hsa:224
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P51648
constant: false
type: Species

metaR SPMDOX
name: Spermidine:(acceptor) oxidoreductase
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: beta-Alanine metabolism EC Number: 1.5.99.6 Confidence Level: 2 AUTHORS: PMID:10657958 NOTES:SAB
is described by: ECO:0000000
reversible: false
product: MODEL1310110036#
is: SBO:0000176
type: Reaction

metaM pro D e
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: D-proline
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: CHEBI:16313
is: HMDB03411

http://identifiers.org/biomodels.db/MODEL1310110036#_f1c7223f_4676_4451_bf02_acf5ee492bdc
has part: Q92536
is: SBO:0000297
initial concentration: NaN
constant: false
is encoded by: hsa:9057
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: SLC3A2:SLC7A6

metaM HC01406 m
name: 3-Oxooctanoyl-CoA
is: CHEBI:28264
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
is: SBO:0000247

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM xu1p D c
has only substance units: false
type: Species
initial amount: NaN
name: D-Xylulose 1-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB06534

http://identifiers.org/biomodels.db/MODEL1310110036#_232f612b_d78e_4621_be55_b0f0e627dba1
name: ACAD8
constant: false
is encoded by: hsa:27034
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q6ZWP6

metaR HSD3A2r
reversible: true
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reactant: MODEL1310110036#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false

metaR r2507
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reactant: MODEL1310110036#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_b2fad25f_369a_49e5_aa11_e658cac1b99b
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is: Q9H6R3
name: ACSS3
is encoded by: hsa:79611

http://identifiers.org/biomodels.db/MODEL1310110036#_16154bcd_5f71_486b_938d_b0c65ae77e1f
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:F23536
is: SBO:0000252
name: _F23536_1_m
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_3add78c6_814d_4283_9ff0_a10ac70067dc
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:56606
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
name: SLC2A9

metaM crm hs g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: N-acylsphingosine
is: CHEBI:52639
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
constant: false

metaR r1904
modifier: MODEL1310110036#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM 1pipdn2c x
boundary condition: false
has only substance units: false
is: HMDB01084
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: CHEBI:16187
constant: false
initial amount: NaN
name: 1-piperideine-2-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110036#_d5675ef4_e0bd_4e4f_8519_ee8b2bc7060d
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110036#_a58c517e_085d_478c_b7e6_78e23bc96270
type: Species
name: PANK1
is: Q8TE04
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:53354
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_22fa0bfa_e3a5_4d29_862a_f3893475aae7
constant: false
initial concentration: NaN
is encoded by: hsa:5294
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:10870
has part: P48736
is: SBO:0000297
boundary condition: true
has part: Q9UBK5
name: HCST:PIK3CG

http://identifiers.org/biomodels.db/MODEL1310110036#_3ba14b21_2572_41da_8ebf_748fba8f8bd0
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4711
name: NDUFB5
boundary condition: true
has only substance units: false
is: O43674
initial concentration: NaN
type: Species
constant: false

metaM 1pyr5c c
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: CHEBI:15893
is: C03912
is: SBO:0000247
name: 1-Pyrroline-5-carboxylate
type: Species
is: HMDB01301

http://identifiers.org/biomodels.db/MODEL1310110036#_3a1d403f_49d2_4cd4_96b7_98170e3804ec
boundary condition: true
initial amount: NaN
constant: false
is: Q9UGQ3
name: SLC2A6
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11182

http://identifiers.org/biomodels.db/MODEL1310110036#_0a940092_4781_4b4f_852a_d3bd3563ecf0
boundary condition: true
is encoded by: hsa:23236
constant: false
name: PLCB1
is: SBO:0000252
is: Q9NQ66
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR ACETONEt2m
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
name: acetone mitochondrial transport via proton symport
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
modifier: MODEL1310110036#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110036#

metaR HEXDIACTD
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaM arachdcoa x
constant: false
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial concentration: 1.0
is: CHEBI:57368
type: Species
boundary condition: false
has only substance units: false
is: HMDB06523
is: SBO:0000247
name: arachidonoyl-CoA(4-)

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR r1903
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: false
reactant: MODEL1310110036#
name: Y+LAT2 Utilized transport

metaR INSt
reversible: true
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
modifier: MODEL1310110036#
name: Inosine transport (diffusion)
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110036#_16e1a230_c14f_4712_b0c0_1a4f99275528
name: _286297_1_c
is encoded by: hsa:286297
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM CE5118 m
boundary condition: false
is: CHEBI:57923
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
has only substance units: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA

metaR SMS
is: SBO:0000176
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.8.27
fast: false
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
type: Reaction
name: Sphingomyelin synthase (homo sapiens)
product: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#

metaM gullac r
type: Species
initial concentration: 1.0
is: HMDB03466
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
name: L-gulono-1,4-lactone
is: SBO:0000247
is: CHEBI:17587
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_32768446_788d_4391_aa5f_53761e2ebcbf
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: B4DZR2
type: Species
constant: false
is encoded by: hsa:8854
name: ALDH1A2
boundary condition: true

metaM pep c
type: Species
boundary condition: false
name: Phosphoenolpyruvate
is: HMDB00263
is: CHEBI:18021
initial concentration: 1.0
is: C00074
is: SBO:0000247
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_6909bc32_9a61_44f1_9c48_ebf141e632f2
initial concentration: NaN
constant: false
is: P43304
has only substance units: false
type: Species
is encoded by: hsa:2820
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: GPD2

http://identifiers.org/biomodels.db/MODEL1310110036#_fa278a8c_0ea4_45be_b8f5_32d43ae607e4
is: SBO:0000252
initial concentration: NaN
name: _D87002_1_e
type: Species
has only substance units: false
is encoded by: hsa:D87002
initial amount: NaN
constant: false
boundary condition: true

metaR HEXDICOAACBPx
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaR LYStip
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000
name: L-lysine transport, peroxisomal (irreversible)
product: MODEL1310110036#
type: Reaction
fast: false
reversible: false

metaR PROSTGE1t
reversible: true
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110036#
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110036#
modifier: MODEL1310110036#

metaM tsul m
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
name: thiosulfate(2-)
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00257

metaR r2509
product: MODEL1310110036#
name: Utilized transport
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110036#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_d95ad21d_db46_4938_b8d0_b9f8c5b7b4ef
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: RDH14
boundary condition: true
type: Species
is: Q9HBH5
is encoded by: hsa:57665
has only substance units: false

metaM gluside hs g
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
type: Species
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_0aad4762_17d9_4ef0_a454_563fb944a1b8
is: SBO:0000252
name: ALDH2
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: P05091
has only substance units: false
is encoded by: hsa:217
boundary condition: true

metaM ctp c
is: C00063
name: CTP
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
is: HMDB00082
is: CHEBI:37563
initial amount: NaN

metaM q10 m
name: ubiquinone-10
constant: false
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01072
has only substance units: false
is: SBO:0000247
is: CHEBI:46245

http://identifiers.org/biomodels.db/MODEL1310110036#_7b1ae991_2e69_49a5_9dc2_341949142db0
is encoded by: hsa:8309
has only substance units: false
type: Species
initial amount: NaN
is: Q99424
boundary condition: true
name: ACOX2
is: SBO:0000252
initial concentration: NaN
constant: false

metaR DCSPTN1CPT2
reactant: MODEL1310110036#
is described by: ECO:0000000
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
type: Reaction
fast: false
name: carnitine transferase
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_035a8ae7_678c_4958_b2eb_88b655ec763b
name: _R14373_1_x
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:R14373
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_8b2b04ab_cf72_401e_8728_3c3a048cd2d2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: ST3GAL1
is encoded by: hsa:6482

metaM accoa g
constant: false
boundary condition: false
type: Species
has only substance units: false
name: acetyl-CoA(4-)
initial concentration: 1.0
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
is: CHEBI:57288
is: SBO:0000247

metaR CH25H
kinetic law: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110036#
is described by: ECO:0000269
product: MODEL1310110036#
name: cholesterol 25-hydroxylase
fast: false
is version of: http://identifiers.org/ec-code/1.14.99.38
is: SBO:0000176
reversible: false

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM lnlncgcoa c
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57363

http://identifiers.org/biomodels.db/MODEL1310110036#_6f4d9efc_50bb_46ec_8b61_cfd648430d92
is: SBO:0000252
initial concentration: NaN
name: MIA3
is encoded by: hsa:375056
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: Q5JRA6

metaR MTHFC
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110036#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
type: Reaction
name: methenyltetrahydrofolate cyclohydrolase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_2037bcf3_65f8_408e_a534_dfdc27749529
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:50484
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: RRM2B
boundary condition: true
is: Q7LG56

http://identifiers.org/biomodels.db/MODEL1310110036#_e9829e93_1f44_43aa_ac8c_a98cf0beb686
type: Species
initial amount: NaN
has part: P53597
is encoded by: hsa:8802
constant: false
name: SUCLG2:SUCLG1
has only substance units: false
boundary condition: true
has part: Q96I99
initial concentration: NaN
is encoded by: hsa:8801
is: SBO:0000297

metaR r0422
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
type: Reaction
product: MODEL1310110036#

metaM 34dhpha c
boundary condition: false
is: CHEBI:17612
constant: false
has only substance units: false
is: HMDB01336
type: Species
name: (3,4-dihydroxyphenyl)acetate
initial amount: NaN
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110036#_db6abec7_c2bc_4f11_8f82_34b585d46f28
boundary condition: true
has only substance units: false
name: PRDX2
constant: false
is encoded by: hsa:7001
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaM dcholcoa x
is: HMDB06292
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
is: CHEBI:28701
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110036#_43dd0e73_59d6_48ee_9cfb_25f94af139f0
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: Q8N5Z0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:51166
name: AADAT

metaR RE1518M
is: SBO:0000176
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110036#
fast: false
type: Reaction
name: RE1518
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110036#

metaR MALTSULtm
modifier: MODEL1310110036#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: Malate:thiosulfate antiport, mitochondrial

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR DCSPTN1CPT1
product: MODEL1310110036#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110036#
name: carnitine O-palmitoyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110036#
fast: false
modifier: MODEL1310110036#

metaR DITPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
name: dITP nuclear transport
is: SBO:0000185
type: Reaction
product: MODEL1310110036#

metaR GRTTx
type: Reaction
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
is: SBO:0000176
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.5.1.1
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
name: geranyltranstransferase

metaM xol25oh r
name: 25-hydroxycholesterol
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
is: CHEBI:42977
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB06247

http://identifiers.org/biomodels.db/MODEL1310110036#_90232a8e_075e_4d65_a968_858364df54d2
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI480132
type: Species
initial amount: NaN
is: SBO:0000252
name: _AI480132_1_c
initial concentration: NaN

metaR LPS3
is described by: ECO:0000000
modifier: MODEL1310110036#
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.23
kinetic law: MODEL1310110036#
name: lipase

metaR MTHFD
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
name: methylenetetrahydrofolate dehydrogenase (NADP)
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.5
type: Reaction
kinetic law: MODEL1310110036#
is described by: ECO:0000134
modifier: MODEL1310110036#
reversible: true
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#

metaR APAT2rm
type: Reaction
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
kinetic law: MODEL1310110036#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000212
modifier: MODEL1310110036#
fast: false
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)

metaR r0423
reversible: true
product: MODEL1310110036#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110036#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110036#
is: SBO:0000176
kinetic law: MODEL1310110036#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_dec6ec62_7f23_4ecd_bdf0_d9ac43fb9ab9
is: SBO:0000252
is encoded by: hsa:5198
constant: false
initial amount: NaN
name: PFAS
has only substance units: false
type: Species
boundary condition: true
is: Q6P4B4
initial concentration: NaN

metaR TRDRm
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.9
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110036#
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110036#
modifier: MODEL1310110036#
product: MODEL1310110036#

metaM so3 m
is: CHEBI:17137
constant: false
has only substance units: false
boundary condition: false
name: hydrogensulfite
initial concentration: 1.0
is: HMDB00240
type: Species
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: SBO:0000247

metaR r0494
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110036#
product: MODEL1310110036#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_e976a1b5_255b_4fc4_908b_ae0313d2178d
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: B3KXN9
name: ADO
has only substance units: false
initial amount: NaN
is encoded by: hsa:84890
boundary condition: true

metaR r1908
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110036#
reversible: false
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
name: Y+LAT2 Utilized transport

metaM glu5p m
has only substance units: false
constant: false
type: Species
is: HMDB01228
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: L-Glutamate 5-phosphate
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
is: CHEBI:58274

metaR DHFtm
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reversible: true
name: dihydrofolate reversible mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

metaM q10h2 m
name: Ubiquinol-10
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB13111
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110036#_34f0b0c5_30f1_4501_b355_7e92e0b17e24
type: Species
name: SLC16A7
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9194
is: Q8NEM3
initial amount: NaN
constant: false

metaR r0424
fast: false
product: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is version of: http://identifiers.org/ec-code/1.17.1.4
reactant: MODEL1310110036#
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176

metaM acgam c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:17411
is: HMDB00215
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine

metaR LPS2
kinetic law: MODEL1310110036#
name: lipase
type: Reaction
is: SBO:0000176
product: MODEL1310110036#
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/3.1.1.34
reversible: false
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_9a39db7e_fae5_401e_823c_cdacaea89369
name: COX1
boundary condition: true
type: Species
initial concentration: NaN
is: Q7GXY8
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4512
constant: false

metaR r1880
name: Y+LAT2 Utilized transport
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
reactant: MODEL1310110036#
modifier: MODEL1310110036#
reversible: false
type: Reaction

metaR UMPK4n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (GTP),nuclear
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
product: MODEL1310110036#

metaR PMEVKx
kinetic law: MODEL1310110036#
name: phosphomevalonate kinase
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.2
modifier: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reactant: MODEL1310110036#
product: MODEL1310110036#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110036#_48c9d5f9_cebc_4519_9aad_a04bcb2b8296
constant: false
is: SBO:0000252
name: ACAT1
type: Species
is: P24752
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:38
has only substance units: false

metaR r0497
kinetic law: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.2.4.2
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is: SBO:0000176
reversible: true

metaM hdd2coa x
is: SBO:0000247
name: (E)-hexadec-2-enoyl-CoA(4-)
has only substance units: false
is: HMDB03945
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
constant: false
is: CHEBI:61526
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r2506
name: Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
is: SBO:0000185

metaR KYN
is version of: http://identifiers.org/ec-code/3.7.1.3
name: kynureninase
reversible: false
reactant: MODEL1310110036#
product: MODEL1310110036#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8942.1) SUBSYSTEM: Tryptophan metabolism EC Number: 3.7.1.3 Confidence Level: 4 AUTHORS: PMID:9180257 NOTES:NCD
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
type: Reaction

metaM frdp r
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:175763
initial concentration: 1.0
is: HMDB00961
name: Farnesyl diphosphate
has only substance units: false
is: C00448
type: Species
constant: false

metaM 2dr1p c
constant: false
type: Species
boundary condition: false
is: C00672
is: SBO:0000247
initial concentration: 1.0
name: 2-Deoxy-D-ribose 1-phosphate
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: HMDB01351
is: CHEBI:58576
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_c20302d8_37a8_44bd_ab88_f6a385bcf3ae
is: SBO:0000252
is: Q16850
initial amount: NaN
boundary condition: true
name: CYP51A1
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1595
type: Species

http://identifiers.org/biomodels.db/MODEL1310110036#_97e9dfdf_1f4f_4675_93c5_43668329e336
is encoded by: hsa:AI697028
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _AI697028_1_e
constant: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_78380909_d0b1_416f_92e2_c46cc21a0835
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is: Q9H845
name: ACAD9
constant: false
is encoded by: hsa:28976

http://identifiers.org/biomodels.db/MODEL1310110036#_63b65954_d843_4cb3_81bb_1ddc3861d033
is: Q5FC00
has only substance units: false
name: CA6
is encoded by: hsa:765
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaM oxa x
is: SBO:0000247
is: CHEBI:30623
has only substance units: false
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB02329
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_5f074fe1_fa41_4967_9541_a942795eb8b1
is encoded by: hsa:7296
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: TXNRD1
type: Species
initial concentration: NaN

metaR NDP3ex
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (GDP), extracellular
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
is: SBO:0000176
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110036#
type: Reaction
fast: false
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#

metaR r0425
name: EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
reversible: true
fast: false
product: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
type: Reaction
is described by: ECO:0000000

metaM 3mob m
boundary condition: false
initial concentration: 1.0
is: HMDB00019
initial amount: NaN
is: CHEBI:11851
is: SBO:0000247
constant: false
has only substance units: false
type: Species
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141

http://identifiers.org/biomodels.db/MODEL1310110036#_d1e7f4d3_393d_4063_b7a5_59fb98c670ce
is encoded by: hsa:23236
constant: false
boundary condition: true
has only substance units: false
type: Species
name: PLCB1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_e39b800c_8168_4e17_b4b6_c6f32bb8f0d0
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: CCBL1
boundary condition: true
initial concentration: NaN
is: Q16773
type: Species
constant: false
is encoded by: hsa:883

http://identifiers.org/biomodels.db/MODEL1310110036#_18bc22a0_475c_4984_a96b_9b880fe584af
constant: false
is encoded by: hsa:1351
initial amount: NaN
boundary condition: true
type: Species
name: COX8A
has only substance units: false
initial concentration: NaN
is: Q53XN1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_580eb945_d60b_4893_b7cd_ea9092dcddeb
initial concentration: NaN
constant: false
has part: P08237
is encoded by: hsa:5213
name: PFKM:PFKP
boundary condition: true
is: SBO:0000297
has only substance units: false
type: Species
initial amount: NaN

metaR ATPtx
reversible: true
reactant: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110036#
kinetic law: MODEL1310110036#
name: ATP transporter, peroxisomal

metaM dsT antigen g
notes: FORMULA: C36H56N3O26X CHARGE: -2
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: disialyl-T antigen
is: CHEBI:16497
is: HMDB01440

http://identifiers.org/biomodels.db/MODEL1310110036#_1720e118_bd09_4d18_8009_bf79c718c842
initial concentration: NaN
name: SLC29A1
initial amount: NaN
is encoded by: hsa:2030
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is: Q99808

http://identifiers.org/biomodels.db/MODEL1310110036#_40e6bba3_f53c_4faa_99fd_48628c854c1e
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q9UIG8
is encoded by: hsa:28232
name: SLCO3A1
constant: false
initial amount: NaN

metaR RE3524R
name: RE3524
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
product: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110036#_388eb341_dc6c_470f_b9b1_80c6c712a0d3
initial amount: NaN
name: _T83654_1_e
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:T83654

metaR RE1897C
is: SBO:0000176
kinetic law: MODEL1310110036#
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
reversible: true
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
fast: false
name: RE1897

metaR r0179
product: MODEL1310110036#
type: Reaction
reactant: MODEL1310110036#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000176
modifier: MODEL1310110036#
reversible: true
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.27

metaM oxa e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:30623
name: oxalate(2-)
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329
boundary condition: false
type: Species
constant: false

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR r1665
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110036#
reactant: MODEL1310110036#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_af1c5c43_9959_4545_84b2_29584e87d4dc
boundary condition: true
has only substance units: false
initial amount: NaN
is: C9JFZ1
constant: false
name: SYNJ1
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8867

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR r0926
reversible: false
type: Reaction
name: Postulated transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
is: SBO:0000185
product: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110036#_cbe1dd62_ccb1_43b6_8cc2_f2dd0b630414
type: Species
name: SLC26A7
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:115111
is: SBO:0000252
constant: false
has only substance units: false

metaM o2s e
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB02168
name: superoxide
has only substance units: false
type: Species
is: CHEBI:18421
constant: false

metaM HC00319 m
has only substance units: false
boundary condition: false
name: Malonate
initial concentration: 1.0
is: CHEBI:30794
constant: false
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
initial amount: NaN

metaM 3odcoa m
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
name: 3-Oxodecanoyl-CoA
constant: false
initial concentration: 1.0
is: HMDB03939
boundary condition: false
has only substance units: false
is: CHEBI:28528

metaM r5p r
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:18189
is: HMDB00618
is: SBO:0000247
has only substance units: false
type: Species
name: alpha-D-Ribose 5-phosphate
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117

http://identifiers.org/biomodels.db/MODEL1310110036#_2dbba9ad_5be5_41d8_a413_1ccc98ae8fc0
is encoded by: hsa:2686
initial concentration: NaN
is: A0PJJ9
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: GGT7
has only substance units: false
is: SBO:0000252

metaR ACt2m
reversible: true
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
kinetic law: MODEL1310110036#
name: acetate mitochondrial transport via proton symport

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR PItx
type: Reaction
name: Phosphate transporter, peroxisome
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
kinetic law: MODEL1310110036#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110036#

metaR PIK3
kinetic law: MODEL1310110036#
product: MODEL1310110036#
fast: false
reversible: false
modifier: MODEL1310110036#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.137
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
type: Reaction
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
name: phosphatidylinositol 3-kinase

metaM ahcys e
has only substance units: false
is: C00021
is: HMDB00939
boundary condition: false
initial amount: NaN
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0
initial concentration: 1.0
is: CHEBI:16680
type: Species
is: SBO:0000247
constant: false

metaR r1664
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
reversible: true
reactant: MODEL1310110036#
is described by: ECO:0000000

metaM cit c
type: Species
name: Citrate
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16947
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00158
is: HMDB00094
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158

metaM 2mop c
is: SBO:0000247
is: HMDB01172
is: CHEBI:57700
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
name: 2-methyl-3-oxopropanoate
type: Species
constant: false
initial concentration: 1.0

metaR r0208
is described by: ECO:0000000
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/4.4.1.1
fast: false
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
kinetic law: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
reversible: true
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
reactant: MODEL1310110036#
is: SBO:0000176

metaR FAOXC1811603m
reversible: false
kinetic law: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
name: Beta oxidation fatty acid
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110036#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR MANt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110036#
reversible: true
name: D-mannose transport via sodium cotransport
is: SBO:0000185
type: Reaction
product: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is described by: ECO:0000269

metaM 7dhf e
is: HMDB06559
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false
boundary condition: false
name: heptaglutamyl folate (DHF)

metaR r1777
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110036#

metaR BILGLCURtr
fast: false
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
is described by: ECO:0000000
reversible: true
name: glucuronidated compound transport

metaR r1557
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110036#
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_8600ab75_9263_4b7c_bf59_178dafbe3117
type: Species
initial amount: NaN
has only substance units: false
has part: E5KS60
boundary condition: true
name: SUCLG1:SUCLA2
constant: false
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:8803

metaM mi14p c
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial concentration: 1.0
is: CHEBI:58282
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00968

http://identifiers.org/biomodels.db/MODEL1310110036#_2118aa79_218f_49a8_a5da_28df7fe34547
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: B7Z6Q4
type: Species
is encoded by: hsa:3612
name: IMPA1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_e22b1a6f_4925_4d99_85da_9581e39a7410
is encoded by: hsa:160287
name: LDHAL6A
is: Q6ZMR3
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r1556
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
is: SBO:0000185
kinetic law: MODEL1310110036#
is described by: ECO:0000000

metaR PROSTGI2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
name: Prostaglandin I2 transport
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
fast: false

metaR r0651
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110036#
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
modifier: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_72434384_a22b_434c_afe6_1e3ee800ad6e
has only substance units: false
name: ADH5
is: SBO:0000252
is encoded by: hsa:128
is: Q6IRT1
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR r0060
is described by: ECO:0000000
name: L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
product: MODEL1310110036#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#

metaM o2s c
is: HMDB02168
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
initial amount: NaN
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
has only substance units: false
is: CHEBI:18421

metaR r1667
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: true
fast: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110036#
product: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_bd666f2b_67ee_4313_b94c_296aa343554f
name: GART
is encoded by: hsa:2618
has only substance units: false
constant: false
is: Q59HH3
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110036#_f86c4d20_c0a6_40fe_930b_d48b012a14e0
name: OGDH
is encoded by: hsa:4967
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: Q02218

metaR r0717
is: SBO:0000176
reversible: false
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_deafc639_1fec_4298_8c79_7c29332e0010
constant: false
has only substance units: false
is encoded by: hsa:10050
is: Q9Y2C5
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: SLC17A4
is: SBO:0000252
type: Species

metaM oxa c
initial amount: NaN
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
has only substance units: false
is: CHEBI:30623
constant: false
is: HMDB02329
is: SBO:0000247
name: oxalate(2-)
initial concentration: 1.0

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR FACOAL181i
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110036#
name: C181 fatty acid activation
type: Reaction
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110036#
product: MODEL1310110036#
modifier: MODEL1310110036#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases

http://identifiers.org/biomodels.db/MODEL1310110036#_54c39017_c5d7_468b_8147_968bb155b602
has only substance units: false
is encoded by: hsa:19
initial concentration: NaN
name: ABCA1
boundary condition: true
is: O95477
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_89209582_613b_4a8f_9c4d_9510f3b63f76
initial amount: NaN
is encoded by: hsa:768
is: Q16790
is: SBO:0000252
has only substance units: false
name: CA9
boundary condition: true
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_588e81cf_a0ab_455f_ba15_478ebc374f3e
initial concentration: NaN
boundary condition: true
is: O75715
constant: false
is encoded by: hsa:2880
is: SBO:0000252
type: Species
name: GPX5
has only substance units: false
initial amount: NaN

metaR r1666
fast: false
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
modifier: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
is described by: ECO:0000000
reversible: true
type: Reaction

metaR SO4t4 2
fast: false
is described by: ECO:0000269
modifier: MODEL1310110036#
name: sulfate transport via sodium symport
reversible: true
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
is: SBO:0000185
type: Reaction

metaR r0650
type: Reaction
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
kinetic law: MODEL1310110036#

metaM cit e
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
constant: false
is: CHEBI:16947
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00094
name: citrate(3-)

metaR r2369
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110036#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110036#
reversible: true
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110036#

metaM malthp e
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/5041
type: Species
name: maltoheptaose
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110036#_9f83a4b6_fce7_4510_8ccf_3ea54feb775c
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:U37519
type: Species
initial concentration: NaN
name: _U37519_1_c
boundary condition: true
has only substance units: false

metaR MALSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
name: Malate:sulfate antiport, mitochondrial
kinetic law: MODEL1310110036#
reversible: true
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110036#
reactant: MODEL1310110036#
fast: false

metaM prostge1 c
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57397
is: HMDB01442
has only substance units: false
name: prostaglandin E1(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR Coqe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110036#
product: MODEL1310110036#
reactant: MODEL1310110036#
type: Reaction
reversible: true
name: Transport of q10
is described by: ECO:0000134
fast: false
is: SBO:0000185

metaR FAOXC2251836m
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
kinetic law: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
product: MODEL1310110036#
reactant: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_bdfde5cf_cdbb_4c84_8e87_677c3bb868c0
initial concentration: NaN
name: IDH2
is: P48735
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:3418

metaR r0310
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false
type: Reaction
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
product: MODEL1310110036#
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaM glyc R c
is: HMDB00139
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16659
name: D-glycerate
has only substance units: false

metaM 2maacoa m
initial amount: NaN
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157
is: CHEBI:57335
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: 2-methylacetoacetyl-CoA(4-)
constant: false
has only substance units: false

metaR r1661
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
modifier: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0276
modifier: MODEL1310110036#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is: SBO:0000176
product: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110036#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_dcf8add8_d8ea_420c_832b_0c4caf063caa
initial concentration: NaN
is: P23677
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: ITPKA
has only substance units: false
is encoded by: hsa:3706
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_7ac77ac0_2a2e_4b60_930e_22f702dae87d
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AW277253
constant: false
name: _AW277253_1_c
is: SBO:0000252
initial amount: NaN

metaR ACt2r
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: acetate reversible transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110036#_cdc08e97_c7a9_44d2_88c9_e6c20d394e01
initial amount: NaN
is: O94903
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:11212
initial concentration: NaN
constant: false
name: PROSC
has only substance units: false

metaR CYTK3n
is described by: ECO:0000269
reactant: MODEL1310110036#
name: cytidylate kinase (dCMP,CTP),nuclear
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
kinetic law: MODEL1310110036#
is: SBO:0000176

metaR r1554
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000

metaR PROt4 2 r
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110036#
modifier: MODEL1310110036#
name: Proline transport (sodium symport) (2:1)
fast: false
product: MODEL1310110036#
is described by: ECO:0000006
kinetic law: MODEL1310110036#
type: Reaction

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaM orot5p c
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
name: Orotidine 5'-phosphate
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:57538
is: SBO:0000247
is: C01103
type: Species
boundary condition: false
is: HMDB00218
initial amount: NaN

metaR ADRNCOAtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#
reversible: true
reactant: MODEL1310110036#
product: MODEL1310110036#
name: fatty acid intracellular transport

metaM CE5854 e
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: CHEBI:27485
initial concentration: 1.0
is: SBO:0000247
name: gama-CEHC-glucuronide
constant: false
initial amount: NaN
boundary condition: false
is: HMDB02710
type: Species
has only substance units: false

metaM fprica c
initial concentration: 1.0
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58467
is: SBO:0000247
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: C04734
type: Species
is: HMDB01439
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaR ALAGLYexR
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110036#
is: SBO:0000185
name: L-alanine/glycine reversible exchange
product: MODEL1310110036#
reversible: true

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_d4b9c617_6c25_4253_ad52_eddc26a0e423
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3284
is: P26439
type: Species
name: HSD3B2
initial amount: NaN

metaR r2368
fast: false
type: Reaction
kinetic law: MODEL1310110036#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110036#
product: MODEL1310110036#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110036#_a52d7405_5d5a_4293_8851_4ec2ad43e3c5
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: _83530_1_c
is encoded by: hsa:83530
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110036#_54c30cd5_e522_4390_9d8b_d00385f9752a
is: B4DKS0
initial concentration: NaN
name: SLC16A1
constant: false
is encoded by: hsa:6566
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaR r1660
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110036#
type: Reaction
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110036#
is: SBO:0000185

metaR r1553
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
is: SBO:0000185
fast: false
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM fpram c
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
is: HMDB06211
initial concentration: 1.0
boundary condition: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: CHEBI:58478
has only substance units: false
is: C04640
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

metaM hdca r
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: C00249
is: HMDB00220
constant: false
is: CHEBI:7896
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial amount: NaN

metaR C4STMO2Pr
is version of: http://identifiers.org/ec-code/1.1.1.170
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reversible: false
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: C-4 methyl sterol oxidase
kinetic law: MODEL1310110036#
type: Reaction

metaM dlnlcgcoa c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
is: SBO:0000247
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false

metaM 3hbcoa m
name: (S)-3-hydroxybutanoyl-CoA(4-)
boundary condition: false
is: HMDB01166
has only substance units: false
is: CHEBI:57316
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110036#_c9217366_f85a_4286_9bb6_1f53c70b0f11
initial amount: NaN
initial concentration: NaN
constant: false
is: Q13630
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7264
name: TSTA3

metaR RE2972M
kinetic law: MODEL1310110036#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
product: MODEL1310110036#
is: SBO:0000176
reactant: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
type: Reaction
name: RE2972
is version of: http://identifiers.org/ec-code/2.7.1.67
is described by: ECO:0000000
reversible: true

metaM xol7ah2al c
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: SBO:0000247
is: HMDB06894
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
constant: false
has only substance units: false
boundary condition: false

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_b7672fed_f865_4598_8741_f48f86d8c9f5
initial amount: NaN
name: GMPPA
constant: false
boundary condition: true
is encoded by: hsa:29926
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR r2367
is described by: ECO:0000000
reactant: MODEL1310110036#
type: Reaction
product: MODEL1310110036#
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110036#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR r0870
fast: false
reactant: MODEL1310110036#
reversible: true
is: SBO:0000185
product: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/3.1.3.4
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.6.4.13
name: Facilitated diffusion
modifier: MODEL1310110036#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_c135b40e_fb13_40b5_a9e4_fef40613ccba
is encoded by: hsa:3795
name: KHK
has only substance units: false
is: P50053
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR ACOAD10m
product: MODEL1310110036#
reactant: MODEL1310110036#
fast: false
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reversible: false
type: Reaction
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110036#
is: SBO:0000176
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM

metaR r1552
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
reactant: MODEL1310110036#

metaM xylu L c
constant: false
is: HMDB00751
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:17399
boundary condition: false
name: L-xylulose

metaM 4ppcys m
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
initial amount: NaN
boundary condition: false
constant: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
has only substance units: false
is: SBO:0000247
is: CHEBI:59458
initial concentration: 1.0

metaM accoa n
boundary condition: false
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
has only substance units: false
is: HMDB01206
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: acetyl-CoA(4-)

metaM glu5sa m
boundary condition: false
is: HMDB02104
name: L-Glutamate 5-semialdehyde
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:17232
constant: false
is: C01165
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165

metaM 3hmbcoa m
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57312
initial amount: NaN
is: HMDB01356
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
is: SBO:0000247
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405

metaM CE5854 c
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:27485
type: Species
initial amount: NaN
name: gama-CEHC-glucuronide
is: HMDB02710
boundary condition: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854

metaR GAO1g
type: Reaction
name: Ganglioside O-acetylation
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
fast: false
modifier: MODEL1310110036#
product: MODEL1310110036#
reversible: false

metaR EX nadp LPAREN e RPAREN
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110036#_7b64e397_0a38_44c6_ac0e_7e6c4aaa2e20
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: A8K761
name: NDUFB10
boundary condition: true
is encoded by: hsa:4716

http://identifiers.org/biomodels.db/MODEL1310110036#_9286ec8d_7f54_4917_8c4b_a8b3574b822c
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
name: _AA614647_1_c
is encoded by: hsa:AA614647

http://identifiers.org/biomodels.db/MODEL1310110036#_67555205_edfe_4171_98c0_5cf600ace413
initial amount: NaN
is encoded by: hsa:760
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: P00918
name: CA2

metaR DUTPDPn
is described by: ECO:0000269
modifier: MODEL1310110036#
reactant: MODEL1310110036#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
is: SBO:0000176
fast: false
name: dUTP diphosphatase, nuclear
is version of: http://identifiers.org/ec-code/3.6.1.23
kinetic law: MODEL1310110036#
product: MODEL1310110036#

metaR r2366
product: MODEL1310110036#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110036#

http://identifiers.org/biomodels.db/MODEL1310110036#_c6645b3b_1c95_4ec4_8250_5bdfc86e9186
type: Species
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:50506
name: DUOX2
is: Q9NRD8
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM stcoa c
is: CHEBI:57394
boundary condition: false
name: Stearoyl-CoA (n-C18:0CoA)
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
constant: false
initial concentration: 1.0
is: C00412
has only substance units: false
type: Species
is: HMDB01114
initial amount: NaN
is: SBO:0000247

metaR PE HStm
name: phosphatidylethanolamine scramblase
fast: false
type: Reaction
reactant: MODEL1310110036#
product: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM HC02203 c
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
name: prostaglandin-a2
type: Species
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:27820
has only substance units: false

metaM retinal 11 cis c
is: SBO:0000247
name: 11-cis-retinal
is: CHEBI:16066
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB02152
initial amount: NaN
boundary condition: false

metaR r1662
reactant: MODEL1310110036#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110036#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110036#
is described by: ECO:0000000
product: MODEL1310110036#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110036#_8f4a204c_1def_4f3a_9fe0_a943b1fc4b94
is encoded by: hsa:376497
initial concentration: NaN
type: Species
name: SLC27A1
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR PNTK
is version of: http://identifiers.org/ec-code/2.7.1.33
product: MODEL1310110036#
modifier: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110036#
reversible: false
fast: false
name: pantothenate kinase

metaR r0311
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: false
reactant: MODEL1310110036#
modifier: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110036#
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110036#

metaM ahcys c
constant: false
type: Species
initial concentration: 1.0
is: C00021
is: HMDB00939
name: S-Adenosyl-L-homocysteine
initial amount: NaN
is: CHEBI:16680
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021

http://identifiers.org/biomodels.db/MODEL1310110036#_b6e20213_4533_4413_a2a6_a837bce95a40
initial amount: NaN
constant: false
boundary condition: true
name: DGKA
type: Species
is: SBO:0000252
is: P23743
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1606

metaR r1551
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110036#
is described by: ECO:0000000
kinetic law: MODEL1310110036#
fast: false
type: Reaction
reactant: MODEL1310110036#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM dha e
name: glycerone
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:16016
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
type: Species
is: HMDB01882
constant: false

metaM accoa m
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57288
initial concentration: 1.0
constant: false
is: C00024
name: Acetyl-CoA
has only substance units: false
is: HMDB01206

metaR r0178
kinetic law: MODEL1310110036#
type: Reaction
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
fast: false
is: SBO:0000176
modifier: MODEL1310110036#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
reversible: true
product: MODEL1310110036#
reactant: MODEL1310110036#
is version of: http://identifiers.org/ec-code/2.5.1.21

metaR DM fol
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR 3AIB Dtm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
fast: false
name: transport of 3aib_D into mitochondria
reactant: MODEL1310110036#
product: MODEL1310110036#
type: Reaction
kinetic law: MODEL1310110036#
reversible: true
is described by: ECO:0000134

metaM thp2c x
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16987
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
boundary condition: false
name: 1-piperideine-6-carboxylate
initial amount: NaN
type: Species
constant: false
is: HMDB12130
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110036#_ddece317_4427_4802_b287_bf01a0f83742
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI926493
constant: false
name: _AI926493_1_c
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR FACOAL160i
product: MODEL1310110036#
type: Reaction
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
reactant: MODEL1310110036#
fast: false
name: C160 fatty acid activation
is described by: ECO:0000269
is: SBO:0000176
reversible: false
modifier: MODEL1310110036#
kinetic law: MODEL1310110036#
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110036#_f769e022_b47a_4d2c_935f_03e020733072
is: F8WDN9
is: SBO:0000252
name: PPA2
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:27068
initial amount: NaN

metaR SPHS1Pte
name: sphingosine-1-phosphate transport
reversible: true
type: Reaction
product: MODEL1310110036#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
kinetic law: MODEL1310110036#
reactant: MODEL1310110036#
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110036#_3e4d21ec_42c2_43e0_ba1f_283caef35413
is encoded by: hsa:1633
is: P27707
is: SBO:0000252
name: DCK
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN

metaR r2365
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110036#
kinetic law: MODEL1310110036#
product: MODEL1310110036#
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110036#_f5f46844_f8e4_41ee_a73c_19ef39d6c9ea
is: P48448
is: SBO:0000252
is encoded by: hsa:222
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: ALDH3B2
initial concentration: NaN

metaM cysam c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: CHEBI:58029
initial concentration: 1.0
type: Species
name: cysteaminium
is: HMDB02991
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110036#_bf16e3d8_7dd9_408b_9ab4_af552460ef18
has only substance units: false
initial amount: NaN
name: AMT
is: P48728
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:275
type: Species

metaR r2364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110036#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110036#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110036#
is described by: ECO:0000000

metaM HC02210 e
has only substance units: false
type: Species
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
name: prostaglandin-d3
is: SBO:0000247
is: CHEBI:34939
boundary condition: false
initial amount: NaN