http://identifiers.org/biomodels.db/MODEL1310110033#_9adb2992_0655_40cf_ae35_d75cacf888cf
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: Q92523
initial amount: NaN
has only substance units: false
boundary condition: true
name: CPT1B
is encoded by: hsa:1375

metaM ser L e
is: HMDB00187
constant: false
is: CHEBI:17115
is: SBO:0000247
type: Species
name: L-serine
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR r0527
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
type: Reaction
reversible: true
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaM didp n
name: dIDP
initial amount: NaN
is: SBO:0000247
is: CHEBI:28823
constant: false
is: HMDB03536
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_6af90134_5cd3_44dd_bf5c_c21c5d5e8f65
initial amount: NaN
type: Species
is: Q6LEN5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1103
boundary condition: true
has only substance units: false
name: CHAT
constant: false

metaR r2115
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110033#
reversible: true
fast: false
product: MODEL1310110033#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM pydxn c
is: HMDB00239
initial amount: NaN
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16709
name: Pyridoxine
is: C00314
is: SBO:0000247
constant: false
has only substance units: false

metaM pan4p e
name: Pantetheine 4'-phosphate
boundary condition: false
is: C01134
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01416
initial amount: NaN
is: CHEBI:47942
constant: false
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2

metaR UAGALDP
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110033#
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
name: UDP-N-acetylgalactosamine diphosphorylase

metaM 2pg c
has only substance units: false
type: Species
is: CHEBI:58289
is: HMDB03391
is: SBO:0000247
initial amount: NaN
name: D-Glycerate 2-phosphate
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: 1/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1/f/h5,7-8H HEPATONET_1.0_ABBREVIATION: HC00463 EHMN_ABBREVIATION: C00631
is: http://identifiers.org/pubchem.compound/3904
is: C00631
boundary condition: false
constant: false
initial concentration: 1.0

metaM o2 r
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
is: CHEBI:15379
type: Species
name: O2
is: HMDB01377
is: C00007
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaR EX gp1calpha hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GP1c alpha (homo sapiens) exchange
type: Reaction

metaM gluala e
is: HMDB06248
boundary condition: false
is: C03740
is: SBO:0000247
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
initial concentration: 1.0
initial amount: NaN
name: 5-L-Glutamyl-L-alanine
type: Species
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/6503

metaR B MANNASEly
kinetic law: MODEL1310110033#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
modifier: MODEL1310110033#
reversible: false
is described by: ECO:0000000
name: beta-mannosidase, lysosomal
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.25
reactant: MODEL1310110033#

metaM xan c
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: C00385
initial concentration: 1.0
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
constant: false
boundary condition: false
is: CHEBI:17712
is: HMDB00292
name: Xanthine

metaM acrn x
has only substance units: false
name: O-acetylcarnitine
is: CHEBI:57589
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
initial concentration: 1.0
constant: false
boundary condition: false

metaR FACOAL181i
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
name: C181 fatty acid activation
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
product: MODEL1310110033#
reversible: false
fast: false

metaR r2116
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
product: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_6109eb9d_8be7_4985_8892_378bb2d7ce86
name: PLCB2
is: SBO:0000252
is encoded by: hsa:5330
initial amount: NaN
is: Q59F77
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_1bc5f2ce_57f9_49dd_9231_db3b4d2300d7
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
is: E5KS60
initial amount: NaN
is encoded by: hsa:8803
initial concentration: NaN
constant: false
name: SUCLA2

metaM ksii core2 deg9 l
notes: FORMULA: C30H50N3O20X CHARGE: 0
constant: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 9
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false
is: HMDB00143

metaR PROt4 2 r
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000006
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110033#
type: Reaction
name: Proline transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_971109ab_9e5b_46cc_b24d_76d9c875371f
is encoded by: hsa:5106
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PCK2
is: Q16822
initial concentration: NaN
type: Species
boundary condition: true

metaR r2113
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_7aac34c3_8d14_4943_a132_b105de6f9555
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:9583
is: Q9Y227
type: Species
name: ENTPD4
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r0464
type: Reaction
product: MODEL1310110033#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
fast: false
reactant: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#

metaM pan4p c
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:47942
initial amount: NaN
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: C01134
type: Species
name: Pantetheine 4'-phosphate
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_162eacc4_62f4_4110_a27b_39ef527d457b
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1491
type: Species
name: CTH
is: P32929
initial amount: NaN
is: SBO:0000252

metaM retinol cis 11 c
initial concentration: 1.0
name: 11-cis-retinol
initial amount: NaN
is: SBO:0000247
is: HMDB06216
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
constant: false
is: CHEBI:16302
type: Species

metaR NRPPHRt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
reactant: MODEL1310110033#
type: Reaction
name: Norepinephrine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_e7d8cb97_0f6a_47ed_ad8c_5716e4b8f1cd
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: _AA526438_1_c
is encoded by: hsa:AA526438
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_c105793a_13e2_46cb_a8a7_fc5356a30cd8
name: UAP1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q16222
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6675
type: Species

metaR r0679
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true

metaR PHEMEt
name: heme transport
kinetic law: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD

metaM gchola c
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: CHEBI:58235
name: glycocholate
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00138

metaR r2114
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110033#

metaM apoC Lys m
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: CHEBI:32551
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00182
name: Apocarboxylase (Lys residue)
type: Species

metaM pheme c
is: C00032
type: Species
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
name: Protoheme
constant: false
initial amount: NaN
is: HMDB03178
initial concentration: 1.0
is: CHEBI:17627
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM cholcoa x
boundary condition: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB01374
is: CHEBI:57373
is: SBO:0000247
initial amount: NaN

metaM HC02180 e
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: CHEBI:28728
name: thromboxane-b2
is: SBO:0000247
boundary condition: false
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

metaR RE3568C
product: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3568
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
fast: false

metaR r2111
product: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false

metaM 3mox4hoxm m
has only substance units: false
type: Species
name: 3-Methoxy-4-hydroxymandelate
is: CHEBI:27622
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00291
constant: false
initial amount: NaN
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584

metaM o2 m
is: HMDB01377
initial amount: NaN
name: O2
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:15379
constant: false
has only substance units: false
is: SBO:0000247
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaM pheme e
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: CHEBI:17627
name: Protoheme
has only substance units: false
constant: false
boundary condition: false
is: HMDB03178
initial amount: NaN
is: C00032
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM akg c
is: C00026
constant: false
has only substance units: false
is: CHEBI:16810
is: HMDB00208
name: 2-Oxoglutarate
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_0f42e5e6_8cec_4f72_9582_0a49e3563544
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: GSTZ1
is encoded by: hsa:2954
is: SBO:0000252
type: Species

metaR RE0453N
is: SBO:0000176
reversible: true
product: MODEL1310110033#
name: RE0453
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_82bc9d3e_28bf_4185_852e_4ceb6c11608e
is: SBO:0000252
boundary condition: true
name: GALNT4
constant: false
has only substance units: false
type: Species
is encoded by: hsa:8693
is: Q8N4A0
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_d9e81c90_4084_4d4f_a9eb_205cf381a735
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: DHFR
constant: false
is encoded by: hsa:1719
has only substance units: false
boundary condition: true
is: P00374
type: Species

metaM dutp c
is: SBO:0000247
is: C00460
constant: false
type: Species
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
boundary condition: false
name: dUTP
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01191

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaR NDPK1n
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
reactant: MODEL1310110033#
type: Reaction
fast: false
kinetic law: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r2112
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110033#

metaM gchola e
boundary condition: false
notes: FORMULA: C26H43NO6 CHARGE: 0
has only substance units: false
constant: false
type: Species
name: glycocholate
initial amount: NaN
is: HMDB00138
initial concentration: 1.0
is: SBO:0000247

metaM thp2c x
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
name: 1-piperideine-6-carboxylate
is: CHEBI:16987
is: HMDB12130
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaR 3AIBtm
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: false
is: SBO:0000185
name: 3-amino-isobutyrate transport, mitochondrial
modifier: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_95305dac_8672_4d51_b25e_2c1503c908e2
boundary condition: true
is: Q15125
is encoded by: hsa:10682
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: EBP

metaR SCPx
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.176
fast: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
product: MODEL1310110033#
name: peroxisomal thiolase 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
is described by: ECO:0000269
type: Reaction
is: SBO:0000176

metaR r0463
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
type: Reaction
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000176

metaR NDPK1m
is: SBO:0000176
reactant: MODEL1310110033#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reversible: true
modifier: MODEL1310110033#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110033#_7745f11a_0c93_4b53_bc36_f8ef2bb9ffb2
is: O75874
initial amount: NaN
is: SBO:0000252
name: IDH1
is encoded by: hsa:3417
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_8d4048e6_90ad_4df9_8e6d_79e84f96ed13
is: P09669
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1345
type: Species
name: COX6C
boundary condition: true

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_4747be53_7c9d_4c05_a175_afdc714a8488
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: Q5JAM2
is encoded by: hsa:211
name: ALAS1
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM xylu L c
type: Species
name: L-xylulose
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: SBO:0000247
is: HMDB00751
is: CHEBI:17399
constant: false
initial amount: NaN
boundary condition: false

metaR DITPtn
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
fast: false
reversible: true
name: dITP nuclear transport
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110033#
type: Reaction

metaR ARSA
modifier: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
name: Arylsulfatase A
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.8

http://identifiers.org/biomodels.db/MODEL1310110033#_7a0d8c95_d9bb_457a_9c1e_9848567c2ccb
constant: false
name: PYCRL
is encoded by: hsa:65263
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: Q53H96
initial amount: NaN
boundary condition: true

metaR DNDPt36m
type: Reaction
name: dGDP transport via dCDP antiport
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_cc80089e_cb38_4bc9_aa38_24ef2ac70ecb
initial concentration: NaN
is encoded by: hsa:3706
is: SBO:0000252
name: ITPKA
type: Species
is: P23677
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaR ALADGLYexR
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
modifier: MODEL1310110033#
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
name: D-alanine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110033#

metaR r2110
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true

metaM gln L m
is: HMDB00641
constant: false
is: CHEBI:18050
initial concentration: 1.0
type: Species
name: L-glutamine
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_2d4a95c0_e41e_48c2_a28c_825b02adc51c
name: BLVRB
initial concentration: NaN
is: P30043
constant: false
type: Species
boundary condition: true
is encoded by: hsa:645
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_5d6ddcb4_c82b_4d0c_8be9_17adc20f8e0f
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: Q96BD0
boundary condition: true
name: SLCO4A1
has only substance units: false
is encoded by: hsa:28231
is: SBO:0000252

metaR Htg
name: proton diffusion (Golgi)
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000000

metaR RE0453M
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
reversible: true
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000176
name: RE0453

http://identifiers.org/biomodels.db/MODEL1310110033#_f69293fb_78e1_47cf_aebe_b0c48f2dcd7f
boundary condition: true
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
initial concentration: NaN
type: Species
is: SBO:0000297
initial amount: NaN
has only substance units: false

metaR GALASE15ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176

metaM acrn r
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
name: O-acetylcarnitine
has only substance units: false
is: SBO:0000247
is: CHEBI:57589
type: Species
initial concentration: 1.0
is: HMDB00201
initial amount: NaN
constant: false
boundary condition: false

metaR HSPASEly
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
fast: false
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: heparan sulfate proteoglycan protease, lysosome (endosome)
reversible: false

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_70da8092_b952_434f_9041_8478c91cce85
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:84812
name: PLCD4
is: Q9BRC7
boundary condition: true

metaR MELATNOX
fast: false
reactant: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.14.14.1
is version of: http://identifiers.org/ec-code/1.14.13.48
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
name: Melatonin:NADP oxidoreductase
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
modifier: MODEL1310110033#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_fa688a85_fbcb_4eb8_a96d_f0bdbd8591b5
initial concentration: NaN
has only substance units: false
is encoded by: hsa:521
is encoded by: hsa:515
boundary condition: true
has part: P56385
constant: false
has part: P05496
is encoded by: hsa:522
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: P46459
is encoded by: hsa:9551
has part: O75964
type: Species
has part: Q6IBB3
is encoded by: hsa:4905
initial amount: NaN
has part: Q08ET0
is encoded by: hsa:10632
is encoded by: hsa:10476
is: SBO:0000297
has part: A0PJH2
is encoded by: hsa:516

metaM imp c
is: C00130
is: CHEBI:58053
boundary condition: false
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial amount: NaN
name: IMP
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00175

metaM thmpp m
is: HMDB01372
initial amount: NaN
has only substance units: false
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial concentration: 1.0
boundary condition: false
is: CHEBI:45931
constant: false
type: Species
name: Thiamine diphosphate
is: SBO:0000247

metaR FRDPtc
fast: false
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ

http://identifiers.org/biomodels.db/MODEL1310110033#_b855bcf3_5fd1_4d6c_ab04_d98a8b9ad003
constant: false
initial concentration: NaN
is: Q6NVC0
is: SBO:0000252
boundary condition: true
is encoded by: hsa:292
name: SLC25A5
type: Species
initial amount: NaN
has only substance units: false

metaR RE0453C
is: SBO:0000176
name: RE0453
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_bea6042d_4ece_4a4e_8684_aea7104dd512
constant: false
has only substance units: false
name: PPAP2B
type: Species
is: O14495
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8613
boundary condition: true

metaR DESAT18 3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.19.1
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is: SBO:0000176
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
reversible: false
type: Reaction
product: MODEL1310110033#

metaM HC01399 m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
constant: false
name: (S)-3-Hydroxytetradecanoyl-CoA
type: Species
is: CHEBI:27466
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_b5480f38_9eac_4afd_b107_70ea9a38df85
type: Species
is: P05062
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:229
has only substance units: false
name: ALDOB
boundary condition: true
initial concentration: NaN

metaM xol27oh r
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
constant: false
is: SBO:0000247
is: HMDB02103
has only substance units: false
initial amount: NaN
is: CHEBI:17703
type: Species
name: 26-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110033#_fcee3588_0d0d_48ba_99a7_1a2ea1d4b3cd
type: Species
initial amount: NaN
name: GSR
has only substance units: false
is: P00390
is encoded by: hsa:2936
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaM cs e l
constant: false
initial concentration: 1.0
is: HMDB02183
boundary condition: false
is: CHEBI:36005
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
is: SBO:0000247
initial amount: NaN
type: Species

metaM pail345p hs c
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
constant: false
has only substance units: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57836
initial amount: NaN

metaM o2 x
is: CHEBI:15379
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
is: HMDB01377
initial concentration: 1.0
type: Species
is: C00007
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaR PCHOLP hs
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
name: choline phosphatase
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
type: Reaction
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000269

metaR B3GALT3g
is described by: ECO:0000269
name: Beta-1,3-galactosyltransferase 3
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.79
is: SBO:0000176
kinetic law: MODEL1310110033#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_6d5c1974_c514_4840_a43b_31eaa7a21ba9
is encoded by: hsa:2954
initial concentration: NaN
is: A6NED0
name: GSTZ1
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false

metaM ins c
is: C00294
is: CHEBI:17596
boundary condition: false
type: Species
is: HMDB00195
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: Inosine
initial concentration: 1.0
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294

metaM imp e
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00175
is: CHEBI:58053
name: IMP(2-)
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_5da84fbb_81e5_4325_a153_24f7dca3692e
is: Q8N695
initial concentration: NaN
is: SBO:0000252
name: SLC5A8
is encoded by: hsa:160728
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species

metaM succoa x
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01022
name: Succinyl-CoA
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5

metaR GUAPRT
type: Reaction
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false
reversible: false
is described by: ECO:0000269
name: guanine phosphoribosyltransferase
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_5c760692_e149_4d44_9c8a_04816922f249
name: AMY1B
type: Species
has only substance units: false
is encoded by: hsa:277
initial amount: NaN
boundary condition: true
is: P04745
initial concentration: NaN
constant: false
is: SBO:0000252

metaR 25HVITD3tin m
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
name: 25-hydroxyvitamin D3 transport in mitochondria
reversible: false
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r0885
is: SBO:0000185
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
product: MODEL1310110033#

metaR r1088
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction
product: MODEL1310110033#
reversible: true
name: Active transport

metaM gar c
is: C03838
has only substance units: false
boundary condition: false
is: HMDB02022
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:58457
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
initial amount: NaN
name: N1-(5-Phospho-D-ribosyl)glycinamide
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_8a5f6f48_e23f_41bf_b16f_49be42764c11
name: TRNT1
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:51095
boundary condition: true
is: Q96Q11
constant: false
is: SBO:0000252
initial concentration: NaN

metaM acetone c
initial concentration: 1.0
name: acetone
is: HMDB01659
is: CHEBI:15347
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM acrn m
initial amount: NaN
boundary condition: false
name: O-acetylcarnitine
type: Species
is: CHEBI:57589
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201

metaR GULN3D
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: L-gulonate 3-dehydrogenase
is: SBO:0000176
reactant: MODEL1310110033#
reversible: true
product: MODEL1310110033#
type: Reaction
fast: false

metaR H8TAer
modifier: MODEL1310110033#
name: H8 transamidase, endoplasmic reticulum
product: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD

metaM gd3 hs g
type: Species
initial concentration: 1.0
is: CHEBI:28424
constant: false
name: GD3
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2

metaR r2119
is: SBO:0000185
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_13f601d7_d149_4c5f_9ae5_f911079aa539
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:728226
has only substance units: false
type: Species
initial concentration: NaN
name: _728226_1_m

http://identifiers.org/biomodels.db/MODEL1310110033#_0160794a_fa76_47a5_875d_8746ff1c2b5e
is encoded by: hsa:8560
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
name: DEGS1
initial concentration: NaN
is: O15121

metaR r0523
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
reversible: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_73305bf9_3dea_4c26_817b_4990d0b77140
name: SLC38A2
initial amount: NaN
type: Species
is: Q96QD8
constant: false
is encoded by: hsa:54407
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR HIStiDF
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
name: L-histidine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000269
is: SBO:0000185

metaR r0310
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000000

metaM HC02180 c
initial amount: NaN
name: thromboxane-b2
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:28728
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false

metaM acetone e
is: CHEBI:15347
type: Species
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
has only substance units: false
boundary condition: false
name: acetone
is: SBO:0000247
initial concentration: 1.0
is: HMDB01659
constant: false
initial amount: NaN

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM 56dura c
initial concentration: 1.0
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
constant: false
is: HMDB00076
is: SBO:0000247
boundary condition: false
is: CHEBI:15901
has only substance units: false
name: 5,6-dihydrouracil
type: Species
initial amount: NaN

metaM pep m
is: SBO:0000247
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
constant: false
name: Phosphoenolpyruvate
is: CHEBI:18021
initial amount: NaN
is: C00074
initial concentration: 1.0
has only substance units: false
is: HMDB00263
type: Species
boundary condition: false

metaR DAG HSter
reversible: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
name: diacylglycerol ER export
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_71a62d7f_59e3_4b11_98b8_1ac5380bcead
has only substance units: false
is: Q9H845
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ACAD9
is encoded by: hsa:28976
boundary condition: true
constant: false

metaM rib D e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
constant: false
type: Species
has only substance units: false
name: D-ribose
is: CHEBI:16988
is: HMDB00283

http://identifiers.org/biomodels.db/MODEL1310110033#_72ce2e03_39bb_4e86_8bb7_858bbd649792
name: NOS1
type: Species
initial concentration: NaN
boundary condition: true
is: B4DG68
is encoded by: hsa:4842
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaR 3AIB Dtm
reactant: MODEL1310110033#
name: transport of 3aib_D into mitochondria
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000134
product: MODEL1310110033#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
is: CHEBI:28387
is: SBO:0000247
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: HMDB11123

metaM e4p c
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: HMDB01321
is: CHEBI:16897
type: Species
initial concentration: 1.0
constant: false
is: C00279
name: D-Erythrose 4-phosphate

metaM didp c
type: Species
initial concentration: 1.0
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP
initial amount: NaN
has only substance units: false
is: CHEBI:28823
boundary condition: false
constant: false
is: HMDB03536
is: SBO:0000247

metaR r2117
modifier: MODEL1310110033#
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM Lpipecol x
is: HMDB00716
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
initial concentration: 1.0
is: CHEBI:30913
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: L-pipecolic acid
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f7c96504_1b6d_4824_bf5d_5c31bfdfc1d6
initial amount: NaN
is encoded by: hsa:3948
is: SBO:0000252
name: LDHC
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR r0735
reversible: true
type: Reaction
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000

metaM ser L c
name: L-serine
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:17115
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: HMDB00187

metaR RE1516M
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true
name: RE1516
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_0774b4f9_9183_4d8a_95ee_b02bfe1ee0a1
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
name: _H45672_1_m
initial concentration: NaN
is encoded by: hsa:H45672

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR r2118
reversible: true
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110033#
modifier: MODEL1310110033#

metaR RAI1
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
name: retinal isomerase (11-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false

metaR LPS3e
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.1.3
fast: false
type: Reaction
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
name: lipase, extracellular
reactant: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaR r0522
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
modifier: MODEL1310110033#
fast: false
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reversible: false
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

metaM rib D c
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
is: HMDB00283
boundary condition: false
name: D-ribose
is: CHEBI:16988
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_0a838118_ec28_4f2a_ba5d_770db8448471
initial amount: NaN
is encoded by: hsa:AW277253
constant: false
initial concentration: NaN
name: _AW277253_1_c
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaM gln L c
initial concentration: 1.0
is: CHEBI:18050
type: Species
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00641
constant: false
is: SBO:0000247

metaR LEUGLYHYc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
product: MODEL1310110033#
fast: false
reversible: true
kinetic law: MODEL1310110033#
name: hydrolysis of leucylglycine
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110033#

metaM cl e
is: CHEBI:3966
initial amount: NaN
name: Chloride
notes: FORMULA: Cl CHARGE: -1
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: C00115
is: HMDB00492
has only substance units: false
is: SBO:0000247

metaM pglyc hs c
name: phosphatidylglycerol(1-)
is: CHEBI:60523
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0

metaM fucfucgalacglcgalgluside hs e
initial amount: NaN
constant: false
name: Leb glycolipid
is: HMDB00660
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:15824
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
initial concentration: 1.0
is: C00095
boundary condition: false

metaM acac e
type: Species
is: SBO:0000247
name: acetoacetate
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:13705
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0

metaR CYOR u10m
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/3.5.1.92
is: SBO:0000185
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110033#
reversible: false
type: Reaction
kinetic law: MODEL1310110033#
name: ubiquinol-6 cytochrome c reductase, Complex III

metaM lnlccoa c
is: http://identifiers.org/pubchem.compound/5462164
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: HMDB01064
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_98b9f7b3_ae38_40df_9973_7185688a98eb
initial concentration: NaN
is: Q92947
is encoded by: hsa:2639
constant: false
boundary condition: true
name: GCDH
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR PUNP3
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reversible: true
name: purine-nucleoside phosphorylase (Guanosine)
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
is described by: ECO:0000269
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_9655ab36_17c2_47bb_b27e_7661f391f0aa
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:644
name: BLVRA
constant: false
initial concentration: NaN
type: Species
is: P53004

http://identifiers.org/biomodels.db/MODEL1310110033#_303e6589_e6b0_477c_8bab_2792144ed546
is: Q8TB61
is encoded by: hsa:347734
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: SLC35B2

metaM 3oddcoa x
name: 3-Oxododecanoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27868
has only substance units: false
constant: false
type: Species
is: HMDB03937

metaM HC02187 e
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:28774
type: Species
name: reverse-triiodthyronine
constant: false
is: SBO:0000247
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaM CE2435 m
has only substance units: false
is: CHEBI:57795
name: trans,cis-deca-2,4-dienoyl-CoA
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
is: SBO:0000247

metaM acgpail hs c
initial amount: NaN
is: CHEBI:57265
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
constant: false
boundary condition: false
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288

metaR GALNTg
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.1.41
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
kinetic law: MODEL1310110033#
is: SBO:0000176
type: Reaction
name: GalNAc transferase, Golgi apparatus
product: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_c1c634d6_c25f_4c36_b2f7_77e06be15eee
is encoded by: hsa:AI285872
name: _AI285872_1_c
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_841e9035_cb31_4ad2_a065_eae3b5fcb930
is encoded by: hsa:203
constant: false
type: Species
is: P00568
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: AK1

http://identifiers.org/biomodels.db/MODEL1310110033#_32449995_d4a1_4e97_a1aa_ed1974538380
is: SBO:0000252
type: Species
name: ABAT
constant: false
boundary condition: true
is encoded by: hsa:18
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR PUNP2
type: Reaction
product: MODEL1310110033#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyadenosine)
fast: false
is described by: ECO:0000269
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110033#

metaM fucfucgalacglcgalgluside hs g
has only substance units: false
is: CHEBI:18287
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: HMDB00174
constant: false
name: Leb glycolipid
type: Species
initial amount: NaN
is: SBO:0000247

metaM cl c
notes: FORMULA: Cl CHARGE: -1
name: Chloride
is: CHEBI:3966
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00492
has only substance units: false
constant: false
is: C00115
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_0a4958ca_7c2f_44ef_ad32_ce63aceb2541
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI440329
constant: false
initial concentration: NaN
name: _AI440329_1_r
boundary condition: true

metaM akg m
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00208
is: C00026
initial concentration: 1.0
name: 2-Oxoglutarate
is: CHEBI:16810
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026

metaM acac c
type: Species
name: acetoacetate
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
is: CHEBI:13705
is: HMDB00060
initial amount: NaN
initial concentration: 1.0

metaM citr L c
is: CHEBI:16349
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: L-citrulline
initial concentration: 1.0
boundary condition: false
is: HMDB00904
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species

metaR CSNATer
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
product: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
name: carnitine O-acetyltransferase, endolasmic reticulum
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR ACONTm
reversible: true
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
fast: false
is: SBO:0000176
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110033#
name: Aconitate hydratase

metaM HC01399 x
constant: false
is: SBO:0000247
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:27466
has only substance units: false
initial amount: NaN
name: (S)-3-Hydroxytetradecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110033#_999c7b34_e31b_4abc_9f5e_b7fd07772d17
is encoded by: hsa:1374
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q8WZ48
constant: false
name: CPT1A
has only substance units: false
type: Species
boundary condition: true

metaR RE3244R
fast: false
name: RE3244
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_eb0b5446_4ec0_44f2_b884_25b87e235f77
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC25A20
constant: false
is: O43772
initial amount: NaN
is encoded by: hsa:788
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_1a641b64_b4ae_42ea_916f_341107cfaf84
is: SBO:0000252
has only substance units: false
type: Species
name: SLC25A6
constant: false
initial amount: NaN
initial concentration: NaN
is: Q6I9V5
boundary condition: true
is encoded by: hsa:293

http://identifiers.org/biomodels.db/MODEL1310110033#_91aa178c_51b4_41a3_9241_0646e3e89eff
type: Species
initial concentration: NaN
initial amount: NaN
name: PYCR2
constant: false
is encoded by: hsa:29920
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q96C36

metaR ORNALArBATtc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR S6TASE14ly
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000176
product: MODEL1310110033#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true

metaR r0739
type: Reaction
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
reversible: true
product: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_eb1d6f96_98d4_4ba3_8535_bf1943f451fe
is: Q9BY07
is encoded by: hsa:57835
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: SLC4A5
type: Species
initial amount: NaN
is: SBO:0000252

metaM HC02187 c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:28774
name: reverse-triiodthyronine
type: Species
constant: false
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

metaR PUNP4
modifier: MODEL1310110033#
reversible: true
product: MODEL1310110033#
name: purine-nucleoside phosphorylase (Deoxyguanosine)
kinetic law: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
is: SBO:0000176

metaM thbpt c
constant: false
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00027
is: CHEBI:15372
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_0c3628c1_6ba4_46c4_afc8_2d01b7506f3e
type: Species
boundary condition: true
constant: false
is encoded by: hsa:51196
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q9P212
initial concentration: NaN
name: PLCE1

metaR XOL27OHtm
type: Reaction
product: MODEL1310110033#
name: 27 hydroxy cholesterol transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR 3SALAASPm
kinetic law: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
name: cysteinesulfinate-aspartate mitochondrial shuttle
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
reversible: true
product: MODEL1310110033#
is described by: ECO:0000304
modifier: MODEL1310110033#
fast: false
type: Reaction

metaM g1p c
name: D-Glucose 1-phosphate
is: CHEBI:58601
is: HMDB01586
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial amount: NaN
type: Species
has only substance units: false
is: C00103
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_fb51759b_5be9_435e_aaee_c5c9b98dc7f3
name: ENTPD1
is encoded by: hsa:953
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: Q86VV3
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f73535cf_12d0_4592_8fe9_aba7760229ec
type: Species
initial concentration: NaN
is: P49448
has only substance units: false
is: SBO:0000252
name: GLUD2
boundary condition: true
is encoded by: hsa:2747
initial amount: NaN
constant: false

metaR BMTer U
type: Reaction
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
product: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: B mannosyltransferase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110033#_6d45acea_4f4c_41f9_97b5_70b21cd9faa4
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9UFY1
boundary condition: true
has only substance units: false
is encoded by: hsa:5335
name: PLCG1
initial concentration: NaN
type: Species

metaR THFtm
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
reversible: true
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110033#_ad48234f_316f_4869_9da7_10ed511b9cef
boundary condition: true
type: Species
is encoded by: hsa:H53099
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
name: _H53099_1_m
has only substance units: false

metaM citr L e
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00904
constant: false
type: Species
name: citr_L[e]
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349

http://identifiers.org/biomodels.db/MODEL1310110033#_a25c14f3_a595_4fe2_af4b_6bea57afaae9
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:64850
name: AGXT2L1
has only substance units: false
boundary condition: true
is: Q8TBG4
type: Species
is: SBO:0000252

metaR PUNP7
name: purine-nucleoside phosphorylase (Xanthosine)
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
is: SBO:0000176
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
fast: false

metaR RE1533M
is described by: ECO:0000000
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110033#
reversible: true
product: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1533
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction

metaR CDIPTr
modifier: MODEL1310110033#
is described by: ECO:0000000
name: phosphatidylinositol synthase (Homo sapiens)
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
product: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.8.11
reversible: true
is: SBO:0000176
type: Reaction

metaR biomass reaction
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: Generic human biomass reaction
reversible: false
reactant: MODEL1310110033#
product: MODEL1310110033#

metaM ins e
initial concentration: 1.0
is: C00294
type: Species
is: HMDB00195
name: Inosine
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:17596
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294

http://identifiers.org/biomodels.db/MODEL1310110033#_24fb138b_8959_487a_a9fb_29b9367d906e
is: SBO:0000252
is encoded by: hsa:D87002
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: _D87002_1_e
constant: false
initial concentration: NaN

metaR GGH 10FTHF7GLUe
modifier: MODEL1310110033#
is: SBO:0000176
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110033#
type: Reaction

metaR EX fucfucgalacglcgalgluside hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leb glycolipid exchange
type: Reaction

metaR NACHEX26ly
product: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110033#
reversible: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110033#

metaR MTHFDm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial

metaR HAtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: hyaluronan transport, extracellular to lysosome
fast: false
product: MODEL1310110033#
reversible: false
is: SBO:0000185

metaM lald D c
initial amount: NaN
constant: false
name: (R)-lactaldehyde
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17167
boundary condition: false
has only substance units: false
is: HMDB06458
type: Species

metaR GLYCK2
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
reversible: false
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000176
name: glycerate kinase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110033#_fc4ec04b_05cd_4730_950e_ce9b9572f35f
is encoded by: hsa:11226
type: Species
initial concentration: NaN
constant: false
is: Q8NCL4
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: GALNT6

http://identifiers.org/biomodels.db/MODEL1310110033#_57e9988c_548a_4521_933e_361e5fffd319
boundary condition: true
initial amount: NaN
is encoded by: hsa:8897
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q13615
name: MTMR3
type: Species

metaM pglyc hs e
boundary condition: false
name: phosphatidylglycerol(1-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
is: CHEBI:60523
is: SBO:0000247
type: Species
constant: false

metaM pep c
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: Phosphoenolpyruvate
is: C00074
boundary condition: false
is: HMDB00263
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
constant: false
has only substance units: false
is: CHEBI:18021

http://identifiers.org/biomodels.db/MODEL1310110033#_179b0686_a001_44ff_84df_0860637aa05e
boundary condition: true
is encoded by: hsa:AI656480
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: _AI656480_1_m
is: SBO:0000252
initial amount: NaN

metaR N4Tg
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
type: Reaction
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
kinetic law: MODEL1310110033#

metaM retn r
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
name: all-trans-retinoate
initial amount: NaN
is: HMDB01852
is: CHEBI:35291
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM succoa m
is: CHEBI:57292
constant: false
type: Species
is: HMDB01022
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
name: Succinyl-CoA
has only substance units: false
initial amount: NaN

metaM mgacpail hs r
is: CHEBI:7896
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
constant: false
has only substance units: false
boundary condition: false
is: HMDB00220
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: C00249
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_78f931c0_88de_4104_9c94_1d3be71d9290
type: Species
name: _D29675_1_e
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:D29675
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_5e69367e_fbcf_4e46_b112_fdef98df786e
constant: false
boundary condition: true
name: PGM1
is: SBO:0000252
initial concentration: NaN
type: Species
is: B4DPV0
has only substance units: false
is encoded by: hsa:5236
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_c7d0a153_08d2_4c35_bc8b_f156719f34f0
initial amount: NaN
has part: Q07326
has part: Q8TEQ8
is encoded by: hsa:5281
has only substance units: false
is encoded by: hsa:84720
is: SBO:0000297
boundary condition: true
constant: false
name: PIGF:PIGO
initial concentration: NaN
type: Species

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM pi x
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
is: HMDB00973
name: hydrogenphosphate
is: CHEBI:43474
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false

metaR r2347
is: SBO:0000185
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: Organic anion transporter 5 Utilized transport
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaR r2346
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaR NACHEX2ly
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#

MODEL1310110033
reaction: metaR LPCOXp
species: metaM ile L c
species: metaM h2o c
reaction: metaR EX Rtotal LPAREN e RPAREN
reaction: metaR LDH D
species: metaM ksii core4 deg4 l
species: metaM CE1926 e
reaction: metaR EX tdchola LPAREN e RPAREN
reaction: metaR DOLGLCP Uter
reaction: metaR AMETtd
species: metaM HC01603 c
species: metaM cs a deg3 l
reaction: metaR Htg
reaction: metaR NDPK3
reaction: metaR URIt
reaction: metaR EX no LPAREN e RPAREN
species: metaM hs deg3 l
species: metaM sl L c
reaction: metaR r1573
reaction: metaR PIt7
reaction: metaR r1925
reaction: metaR G5SADs
species: metaM dcacoa c
reaction: metaR URIK1
reaction: metaR CRVNCtr
reaction: metaR EX dha LPAREN e RPAREN
reaction: metaR r0629
species: metaM ins c
reaction: metaR RE2974C
reaction: metaR LPCHOLt
species: metaM CE5161 r
reaction: metaR r2111
reaction: metaR DNDPt27m
species: metaM dag hs r
reaction: metaR FUMAC
reaction: metaR r2133
reaction: metaR r0119
reaction: metaR AKGMALtm
reaction: metaR EX gchola LPAREN e RPAREN
species: metaM hestratriol r
species: metaM pser L c
reaction: metaR EX hspg LPAREN e RPAREN
reaction: metaR LEUKTRB4t
reaction: metaR RPEc
reaction: metaR PUNP2
reaction: metaR RETI1
species: metaM glyc3p x
species: metaM ddcacoa m
reaction: metaR DGTPtn
reaction: metaR KCCt
reaction: metaR r0527
reaction: metaR r0715
reaction: metaR N4Tg
species: metaM hspg l
species: metaM pchol hs m
reaction: metaR ST3GAL23g
species: metaM hom L c
reaction: metaR BILGLCURtr
reaction: metaR 2HBt2
reaction: metaR GGT6
reaction: metaR r2090
species: metaM dpcoa e
reaction: metaR r0644
reaction: metaR P5CR
species: metaM leu L m
reaction: metaR r1660
reaction: metaR DATPtn
reaction: metaR NTD8
species: metaM cs e deg5 l
species: metaM 3mox4hoxm m
species: metaM glyc R m
species: metaM ksi deg9 l
species: metaM succ m
reaction: metaR SCPx
reaction: metaR r2311
reaction: metaR r2097
reaction: metaR r0994
reaction: metaR RE1531M
species: metaM cmpacna n
reaction: metaR r2080

http://identifiers.org/biomodels.db/MODEL1310110033#_83b0dfcf_f2dd_445e_81b5_8add8145c39e
is encoded by: hsa:2525
type: Species
constant: false
name: FUT3
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P21217
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_3d5c57d2_6153_45bd_966a_9cc1a200acf7
boundary condition: true
is encoded by: hsa:2879
is: P36969
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: GPX4

http://identifiers.org/biomodels.db/MODEL1310110033#_2f9259ec_73b9_4c5b_8f35_5dff07123ff9
boundary condition: true
is encoded by: hsa:8875
initial amount: NaN
is encoded by: hsa:55350
has part: O95497
type: Species
has part: A8K7W0
initial concentration: NaN
has only substance units: false
name: VNN3:VNN2:VNN1
constant: false
is encoded by: hsa:8876
is: SBO:0000297

metaM ksi deg23 l
is: HMDB00143
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: keratan sulfate I, degradation product 23
constant: false

metaR GQ1Btg
name: gq1b hs intracellular transport
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_63765801_daa3_4588_ab2e_45cf8d8b06d6
name: GMPS
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P49915
constant: false
has only substance units: false
is encoded by: hsa:8833
type: Species
is: SBO:0000252

metaM pi n
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: hydrogenphosphate
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110033#_55bb9917_c7d7_4a44_8126_0439ebcb6fa3
is encoded by: hsa:4645
boundary condition: true
is: SBO:0000252
name: MYO5B
constant: false
is: Q9H6Y6
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

metaR LEUTAm
modifier: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.6.1.42
name: leucine transaminase, mitochondrial

metaR AHCYStd
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
product: MODEL1310110033#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000134
name: diffusion of S-Adenosyl-L-homocysteine
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#

metaR FADH2ETC
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110033#
name: Complex II reaction for respiratory chain
reversible: false
is described by: ECO:0000134

metaM HC02205 e
name: prostaglandin-b2
is: CHEBI:28099
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_c469a963_e680_4c79_a495_402c5afb5a32
is: E5KSL5
is: SBO:0000252
is encoded by: hsa:1716
constant: false
name: DGUOK
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaR r0683
product: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110033#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaM hs deg3 l
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
has only substance units: false
initial amount: NaN
name: heparan sulfate, degradation product 3
constant: false
is: CHEBI:16126
initial concentration: 1.0

metaR BACCLm
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
fast: false
product: MODEL1310110033#
is described by: ECO:0000254
is: SBO:0000176
modifier: MODEL1310110033#
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

metaR r0308
modifier: MODEL1310110033#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
reversible: false
is: SBO:0000176
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#

metaR r2344
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110033#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM ribflv c
is: HMDB00244
constant: false
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: C00255
is: CHEBI:3554
initial amount: NaN
name: Riboflavin
initial concentration: 1.0

metaM pi m
boundary condition: false
initial concentration: 1.0
type: Species
is: C00009
is: CHEBI:43474
is: SBO:0000247
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
has only substance units: false
constant: false
name: hydrogenphosphate

metaM 12ppd R c
initial amount: NaN
is: HMDB01881
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:28972
name: (R)-propane-1,2-diol
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_905385cd_920c_470a_8fac_3f00c4993c1c
type: Species
is: Q9Y233
is: SBO:0000252
name: PDE10A
initial amount: NaN
is encoded by: hsa:10846
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaM ptth m
is: HMDB03426
has only substance units: false
name: pantetheine
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM lnlccoa m
type: Species
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
initial concentration: 1.0
is: HMDB01064
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983

metaM gpi prot hs r
has only substance units: false
initial concentration: 1.0
is: HMDB00220
type: Species
boundary condition: false
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
constant: false
is: CHEBI:7896
is: SBO:0000247
initial amount: NaN
is: C00249
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI

metaM apoC Lys c
initial amount: NaN
constant: false
is: HMDB00182
type: Species
has only substance units: false
notes: FORMULA: C6H13N2OX CHARGE: 0
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Apocarboxylase (Lys residue)
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110033#_783b5548_7c3d_4a25_9b79_e8ae6b367566
initial amount: NaN
type: Species
is: SBO:0000252
is: P49914
boundary condition: true
is encoded by: hsa:10588
has only substance units: false
name: MTHFS
initial concentration: NaN
constant: false

metaM akg e
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: 2-oxoglutarate(2-)
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
is: SBO:0000247
type: Species
is: CHEBI:16810
has only substance units: false

metaM damp c
initial concentration: 1.0
type: Species
name: dAMP(2-)
is: SBO:0000247
boundary condition: false
is: CHEBI:58245
has only substance units: false
is: HMDB00905
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360

metaM citr L m
name: L-citrulline
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
constant: false
is: HMDB00904
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_08ab66f7_f840_460a_a877_e426ee1a8665
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:29925
is: Q9Y5P6
name: GMPPB
initial amount: NaN

metaR r1832
reactant: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM ribflv e
name: Riboflavin
type: Species
constant: false
initial concentration: 1.0
is: HMDB00244
is: SBO:0000247
is: C00255
boundary condition: false
initial amount: NaN
is: CHEBI:3554
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0

metaR ACACT4p
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
type: Reaction
product: MODEL1310110033#
name: acetyl-CoA C-acetyltransferase (octanoyl-CoA), peroxisomal
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110033#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_603fc2b9_4001_4b05_9877_a3ac44b1b0a3
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: G3V0F6
initial concentration: NaN
is encoded by: hsa:8525
name: DGKZ

metaM pi r
is: HMDB00973
name: hydrogenphosphate
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
is: SBO:0000247
is: C00009
has only substance units: false
is: CHEBI:43474
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_9d79d282_5fb0_49ed_b5c5_3613be95b769
is: P49902
has only substance units: false
name: NT5C2
type: Species
is encoded by: hsa:22978
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR r0680
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110033#
reactant: MODEL1310110033#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_cc328478_0810_42ee_b370_7751d6836084
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:6482
name: ST3GAL1

http://identifiers.org/biomodels.db/MODEL1310110033#_bd51e0ea_0743_4475_8e80_bbf3fec54e89
type: Species
is encoded by: hsa:53354
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: PANK1

metaR r2341
fast: false
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#

metaR CYTK11n
reversible: true
fast: false
modifier: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction

metaR r1833
fast: false
kinetic law: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
product: MODEL1310110033#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110033#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR GARFT
name: phosphoribosylglycinamide formyltransferase
fast: false
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
modifier: MODEL1310110033#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.1.2.2

metaR PROSTGE1t
product: MODEL1310110033#
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000269

metaR PUNP1
reversible: true
product: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Adenosine)
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110033#

metaR NACHEX20ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110033#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
kinetic law: MODEL1310110033#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110033#
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_fd3d3daf_0444_4156_b27b_a95126da709d
is: SBO:0000252
is encoded by: hsa:AI469183
name: _AI469183_1_x
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaM andrstandn r
initial concentration: 1.0
has only substance units: false
is: CHEBI:15994
name: 5alpha-androstane-3,17-dione
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
is: HMDB00899
type: Species
initial amount: NaN
constant: false
is: SBO:0000247

metaM fucfucgalacglcgalgluside hs c
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: Leb glycolipid
initial amount: NaN
notes: FORMULA: C56H99N2O30FULLRCO CHARGE: 0
is: HMDB00174
is: SBO:0000247
is: CHEBI:18287

metaR RETNt
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
name: retinoic acid transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110033#_f0774bd3_7222_4b81_8bbb_6983b812c92f
is encoded by: hsa:AI620219
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: _AI620219_1_c
initial concentration: NaN
has only substance units: false

metaM gln L e
initial amount: NaN
is: CHEBI:18050
is: HMDB00641
constant: false
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_369e036e_8c61_4790_a6e3_1da94b559601
constant: false
is: SBO:0000252
is: Q9UPR5
is encoded by: hsa:6543
name: SLC8A2
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

metaM gm3 hs g
has only substance units: false
is: SBO:0000247
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
constant: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
boundary condition: false
initial amount: NaN
is: CHEBI:60065
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_c767a37f_aaab_47db_acc5_4ff4a32bf486
has only substance units: false
constant: false
is: SBO:0000252
is: P25705
is encoded by: hsa:498
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: ATP5A1

metaR GQ1Bte
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
name: gq1b hs transport

metaR r1835
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
product: MODEL1310110033#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM HC02205 c
constant: false
is: CHEBI:28099
initial concentration: 1.0
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
has only substance units: false
boundary condition: false
is: SBO:0000247
name: prostaglandin-b2
initial amount: NaN

metaM HC00229 e
name: Isomaltose
constant: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
is: CHEBI:28189
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247

metaM 6thf e
is: http://identifiers.org/pubchem.compound/169691
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
name: hexaglutamyl folate (THF)
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

metaR r0456
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
modifier: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_d77093af_1b3a_46d1_a196_048660c99725
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is: P37268
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2222
name: FDFT1

metaR CSNAT2m
product: MODEL1310110033#
is: SBO:0000176
name: carnitine O-aceyltransferase, mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
is described by: ECO:0000000
reactant: MODEL1310110033#
reversible: true

metaM ak2lgchol hs e
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6975
has only substance units: false
constant: false
type: Species
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: C04317
initial concentration: 1.0

metaR LEUKTRF4t
kinetic law: MODEL1310110033#
name: leukotriene F4 transport
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110033#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR r0666
type: Reaction
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
modifier: MODEL1310110033#
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
product: MODEL1310110033#

metaR r2101
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_ba4df3c5_37f2_486f_b5c4_ce71d238f6df
boundary condition: true
is encoded by: hsa:6575
initial amount: NaN
type: Species
name: SLC20A2
is: SBO:0000252
constant: false
is: B2RBR4
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_daea4843_d1eb_4c33_a351_f9d33bea7acb
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:84720
name: PIGO

http://identifiers.org/biomodels.db/MODEL1310110033#_9586e014_5456_48c3_8216_6dda2cc2b36d
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:686
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: BTD
is: P43251

http://identifiers.org/biomodels.db/MODEL1310110033#_a69b4e83_1654_4035_ac16_65a41888cf26
constant: false
initial concentration: NaN
is encoded by: hsa:27124
initial amount: NaN
name: INPP5J
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_941c1725_a98f_4b8d_9c13_eb18ee7644cd
has only substance units: false
constant: false
is encoded by: hsa:1339
name: COX6A2
is: SBO:0000252
type: Species
initial amount: NaN
is: Q02221
boundary condition: true
initial concentration: NaN

metaR NDPK2n
reactant: MODEL1310110033#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110033#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
type: Reaction
kinetic law: MODEL1310110033#

metaM nadph r
is: C00005
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
is: CHEBI:57783
is: HMDB00221

metaR 3HCO3 NAt
product: MODEL1310110033#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
name: 3HCO3_NAt
is described by: ECO:0000134
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reversible: true

metaR r2102
fast: false
product: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110033#

metaM ksi deg39 l
is: CHEBI:12936
notes: FORMULA: C48H81N3O36 CHARGE: 0
name: keratan sulfate I, degradation product 39
initial concentration: 1.0
initial amount: NaN
is: HMDB00143
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaR GPDDA1
is: SBO:0000176
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
type: Reaction
product: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaR 3AIBt
kinetic law: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is: SBO:0000185
name: 3-amino-isobutyrate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_217eb6ec_c53a_4a40_9fcb_2eed405772aa
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: PRDX2
is: SBO:0000252
is encoded by: hsa:7001
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_c09ea875_0917_4ffa_9791_9e20d33ad970
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4833
is: O00746
name: NME4

metaR 3HKYNAKGAT
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is described by: ECO:0000304
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.7
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_df30ed0f_855b_4b01_8b69_2978de11c902
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is: P21912
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6390
name: SDHB

metaR r2103
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000000
reversible: true
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_8128259c_9555_429d_8f48_ab39a8ba3e96
type: Species
is: SBO:0000252
is encoded by: hsa:124583
constant: false
is: Q8WVQ1
initial amount: NaN
name: CANT1
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_0a6e4562_6058_47a7_aa4a_8fce762d108f
is: SBO:0000252
is: Q9H2X9
type: Species
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:57468
initial concentration: NaN
name: SLC12A5

metaR r1291
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: Postulated transport reaction
product: MODEL1310110033#
is described by: ECO:0000000

metaR r0668
modifier: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
reversible: true
reactant: MODEL1310110033#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.19
product: MODEL1310110033#

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR PRPPS
kinetic law: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.1
name: phosphoribosylpyrophosphate synthetase
reversible: true
type: Reaction
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_9653ae8d_085a_472e_9af8_9c8f405c3f44
has only substance units: false
is: P27707
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: DCK
is encoded by: hsa:1633
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_4b6fb52d_222a_4ab4_9e6c_58002b784c98
is encoded by: hsa:514
initial amount: NaN
constant: false
has part: A8K092
has part: P30049
initial concentration: NaN
has part: P36542
is encoded by: hsa:506
is encoded by: hsa:513
is encoded by: hsa:509
is: SBO:0000297
has only substance units: false
boundary condition: true
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
type: Species
is encoded by: hsa:498
has part: P06576
has part: P56381

http://identifiers.org/biomodels.db/MODEL1310110033#_d1f858eb_5761_4b16_b573_fd279fdef531
type: Species
initial amount: NaN
has only substance units: false
name: AK4
is encoded by: hsa:205
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is: P27144

metaR r0669
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reactant: MODEL1310110033#
reversible: false
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_de98034f_8288_4785_98ad_42ef42d30462
boundary condition: true
type: Species
constant: false
name: CPT1B
is encoded by: hsa:1375
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q53FV7
initial amount: NaN

metaM 10fthf c
name: 10-Formyltetrahydrofolate
is: HMDB00972
is: SBO:0000247
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57454

metaR NH4t3r
modifier: MODEL1310110033#
name: ammonia transport via proton antiport
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
kinetic law: MODEL1310110033#
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110033#
type: Reaction
is: SBO:0000185

metaM atp r
initial amount: NaN
type: Species
name: ATP(4-)
initial concentration: 1.0
is: CHEBI:57299
constant: false
is: SBO:0000247
is: HMDB00538
boundary condition: false
is: C00002
has only substance units: false

metaR ASPGLUm
is: SBO:0000185
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
name: aspartate-glutamate mitochondrial shuttle
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_4c15f106_db70_4a63_a06a_b774bdb57304
boundary condition: true
initial amount: NaN
is: Q16647
is: SBO:0000252
constant: false
name: PTGIS
is encoded by: hsa:5740
type: Species
initial concentration: NaN
has only substance units: false

metaR TMDK1m
is described by: ECO:0000269
modifier: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.21
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
fast: false
is: SBO:0000176
name: thymidine kinase (ATP:thymidine)
kinetic law: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#

metaM dolglcp U c
type: Species
has only substance units: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
is: CHEBI:15812
constant: false

metaR r2104
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110033#_d0e034a1_ac30_4982_b5cc_c49e7e0e4e1f
type: Species
boundary condition: true
is: A0PJH2
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10476
name: ATP5H

metaR r0517
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
type: Reaction
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110033#
is: SBO:0000176
reversible: true

metaR PA HStn
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
reversible: true
name: phosphatidate transport, nuclear
type: Reaction

metaR DCYTDn
fast: false
reactant: MODEL1310110033#
name: deoxycytidine deaminase, nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.5
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
is described by: ECO:0000254
reversible: false
modifier: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#

metaM memgacpail hs r
boundary condition: false
initial amount: NaN
is: HMDB00054
constant: false
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:57977
type: Species

metaM ksii core2 l
name: keratan sulfate II (core 2-linked)
boundary condition: false
initial concentration: 1.0
is: CHEBI:57614
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00189
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_cc7cb521_cc42_4adb_b1dd_33eaecdf4558
is encoded by: hsa:26266
is: Q9UKG4
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC13A4
initial concentration: NaN
is: SBO:0000252
type: Species

metaM nadph m
is: C00005
is: CHEBI:57783
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_8679518d_ed02_4d00_b94c_5396fea678df
is: O15270
name: SPTLC2
is encoded by: hsa:9517
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM tdcoa x
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
type: Species
is: HMDB01521
is: CHEBI:57385
boundary condition: false
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110033#_823ad146_8bc0_4801_a720_8def34afb218
is encoded by: hsa:159963
is: Q1EHB4
initial concentration: NaN
name: SLC5A12
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_702bbe7f_4080_46c2_a9f3_2691c0297c05
type: Species
initial concentration: NaN
is encoded by: hsa:349565
name: NMNAT3
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: Q96T66

metaM CE5786 e
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB02710
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
has only substance units: false
type: Species
is: CHEBI:27485
initial amount: NaN
name: kinetensin

metaM nh4 c
is: C01342
is: HMDB00051
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
constant: false
is: CHEBI:28938
is: SBO:0000247

metaM dtmp m
is: HMDB01227
constant: false
name: dTMP
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
is: C00364
initial amount: NaN
boundary condition: false
is: CHEBI:26999

metaR r0741
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reversible: true
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m

metaM CE2433 m
initial amount: NaN
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
is: SBO:0000247
is: CHEBI:57795
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433

metaM maltttr e
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
constant: false
is: C02052
name: Maltotetraose
is: HMDB01296
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5141
type: Species
boundary condition: false

metaM ptth c
type: Species
constant: false
has only substance units: false
is: CHEBI:16753
is: HMDB03426
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247
boundary condition: false
name: pantetheine
initial concentration: 1.0
initial amount: NaN

metaM sphings l
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00252
is: CHEBI:57756
name: sphingosine(1+)
boundary condition: false
type: Species
constant: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319

metaR r0450
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
reversible: true
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
kinetic law: MODEL1310110033#
fast: false
type: Reaction

metaR NACHEXA21ly
type: Reaction
name: beta-N-acetylhexosaminidase A, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
modifier: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false

metaM ksi deg33 l
initial concentration: 1.0
constant: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
is: HMDB00143
is: CHEBI:12936
name: keratan sulfate I, degradation product 33
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM itp e
initial concentration: 1.0
is: SBO:0000247
constant: false
name: ITP(3-)
boundary condition: false
is: CHEBI:57614
type: Species
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
is: HMDB00189
has only substance units: false

metaM mercplaccys e
initial concentration: 1.0
name: 3-mercaptolactate-cysteine disulfide
initial amount: NaN
is: HMDB06512
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247

metaR PROSTGI2tr
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
name: Prostaglandin I2 transport (ER)
kinetic law: MODEL1310110033#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
is: SBO:0000185

metaR RE0452M
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110033#
reversible: true
fast: false
name: RE0452

metaM retn c
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
initial amount: NaN
is: HMDB01852
name: all-trans-retinoate
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:35291
has only substance units: false
initial concentration: 1.0

metaM atp n
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57299
name: ATP(3-)
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
initial concentration: 1.0
boundary condition: false
is: HMDB00538
type: Species

metaM itp c
boundary condition: false
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: HMDB00189
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: ITP(3-)

metaR r2100
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_6c83b2f3_1214_4630_a75b_86fae93a5e74
name: AK3
has only substance units: false
boundary condition: true
initial amount: NaN
is: E7ET30
is encoded by: hsa:50808
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaM acgam c
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17411
constant: false
type: Species
name: N-acetyl-D-glucosamine
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140

metaR RE3245C
product: MODEL1310110033#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: RE3245
reversible: true
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
kinetic law: MODEL1310110033#

metaM CE1925 e
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57923
has only substance units: false
is: SBO:0000247
name: 3'-carboxy-alpha-chromanol
constant: false
boundary condition: false
type: Species

metaR LALDO2x
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
kinetic law: MODEL1310110033#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110033#
reactant: MODEL1310110033#
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
modifier: MODEL1310110033#

metaM nh4 e
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
type: Species
boundary condition: false
constant: false
name: ammonium
initial concentration: 1.0
has only substance units: false
is: CHEBI:28938
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_6bf2aa75_4859_4e78_bb88_d2659e3a20e1
is encoded by: hsa:4696
is: SBO:0000252
boundary condition: true
name: NDUFA3
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: O95167
initial concentration: NaN

metaR DUDPtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
kinetic law: MODEL1310110033#
name: dUDP nuclear transport
reversible: true
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#

metaR r2109
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_a5f3b26d_8674_41fe_bc15_02733169c38a
is: P21953
is encoded by: hsa:594
initial amount: NaN
name: BCKDHB
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_fdaafb64_9306_4176_98c4_9df0908c191f
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9BYV1
constant: false
name: AGXT2
type: Species
is encoded by: hsa:64902

http://identifiers.org/biomodels.db/MODEL1310110033#_cc03ff96_8b10_4662_8817_98c316d1dd83
initial amount: NaN
boundary condition: true
is: Q9UJ70
has only substance units: false
name: NAGK
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:55577
type: Species

metaM xol7a r
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01496
has only substance units: false
name: 20-hydroxycholesterol
initial concentration: 1.0
is: CHEBI:1296
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
is: SBO:0000247
constant: false

metaR r0743
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
kinetic law: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
reactant: MODEL1310110033#
reversible: false
is described by: ECO:0000000
is: SBO:0000176

metaR ACALDtm
type: Reaction
is described by: ECO:0000000
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110033#
name: acetaldehyde mitochondrial diffusion
kinetic law: MODEL1310110033#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_c2c34291_5ef4_4f04_b52d_5f82835062b8
initial concentration: NaN
is encoded by: hsa:5634
constant: false
name: PRPS2
is: P11908
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_f7ac4741_f835_49de_af64_a080a50c6858
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5476
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P10619
initial concentration: NaN
name: CTSA

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaM retn e
name: all-trans-retinoate
has only substance units: false
is: HMDB01852
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
is: CHEBI:35291
initial amount: NaN
type: Species

metaR r0744
is described by: ECO:0000000
is: SBO:0000176
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
reversible: false
type: Reaction
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reactant: MODEL1310110033#

metaR UMPK6n
reactant: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110033#
name: UMP kinase (dCTP),nuclear
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true

metaM mercplaccys c
initial amount: NaN
is: HMDB06512
is: SBO:0000247
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
constant: false
has only substance units: false
type: Species
boundary condition: false
name: 3-mercaptolactate-cysteine disulfide
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_c6cfb869_b7bc_4c40_99e3_0cb506c9d54b
is: Q49AT3
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: B3GALNT1
is encoded by: hsa:8706
initial amount: NaN

metaR KYNATESYN
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
is described by: ECO:0000000
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR SERtN1
type: Reaction
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
is: SBO:0000185
fast: false
name: Serine transport (Na, H coupled)
is described by: ECO:0000269
modifier: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_2338036f_c4b3_4cb2_bde9_6fd8fef468db
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SLC6A10P
boundary condition: true
type: Species
constant: false
is encoded by: hsa:386757

metaM ga1 hs g
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0 INCHI: InChI=1S/C19H24O6/c1-9-7-17-8-18(9,24)5-3-10(17)19-6-4-11(20)16(2,15(23)25-19)13(19)12(17)14(21)22/h10-13,20,24H,1,3-8H2,2H3,(H,21,22)/p-1/t10-,11+,12-,13-,16-,17+,18+,19-/m1/s1
initial amount: NaN
is: CHEBI:58524
constant: false
name: gibberellin A1(1-)
boundary condition: false
is: SBO:0000247

metaR NAHCO3 HCLt
fast: false
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000269
modifier: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
name: bicarbonate transport (HCl/NaHCO3 exchange)
type: Reaction
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110033#_e1b55c40_99e7_4b1b_99df_e2f1ae7b8db9
name: ADH7
has only substance units: false
is: SBO:0000252
is: P40394
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:131
boundary condition: true

metaM tdcoa m
boundary condition: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01521
is: SBO:0000247
type: Species
is: C02593
is: CHEBI:57385
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)

metaM pser L c
initial concentration: 1.0
name: O-Phospho-L-serine
is: SBO:0000247
has only substance units: false
is: HMDB01721
type: Species
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
constant: false
boundary condition: false
is: CHEBI:15811
initial amount: NaN

metaM nrvnc c
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB02368
constant: false
is: CHEBI:32392
name: nervonate
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-

http://identifiers.org/biomodels.db/MODEL1310110033#_7055f6f0_d686_48f7_9581_e96a29b4b535
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: BCAT2
is: O15382
initial amount: NaN
type: Species
is encoded by: hsa:587
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_84e9ecb1_1e5b_4977_aa0f_0b8488259830
boundary condition: true
is: Q16851
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:7360
initial concentration: NaN
has only substance units: false
name: UGP2

metaR RE1517M
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110033#
name: RE1517
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13

metaM acac m
has only substance units: false
constant: false
name: acetoacetate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00060
boundary condition: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaM pect e
initial concentration: 1.0
notes: FORMULA: C2535H3509O2535 CHARGE: -1
boundary condition: false
name: pectins
type: Species
constant: false
is: HMDB03402
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR r0899
type: Reaction
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000185
name: Amino acid transporter ATB0+ Facilitated diffusion
reactant: MODEL1310110033#

metaR UDPACGALtl
fast: false
name: udpacgal intracellular transport
reversible: true
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
is: SBO:0000185
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaR r2105
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110033#
reversible: true
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_73647ee5_29b7_4696_a26f_6ccd9490d0d6
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: _LOC374569_1_e
initial concentration: NaN
has only substance units: false
is encoded by: hsa:LOC374569
initial amount: NaN

metaR r0892
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
name: Facilitated diffusion
is: SBO:0000185
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.2.27
type: Reaction
fast: false
reversible: true

metaR r0747
kinetic law: MODEL1310110033#
type: Reaction
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true

metaM dtmp c
is: HMDB01227
boundary condition: false
has only substance units: false
type: Species
name: dTMP
is: CHEBI:26999
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: C00364
constant: false
initial concentration: 1.0

metaM nrvnc e
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: SBO:0000247
is: HMDB02368
constant: false
is: CHEBI:32392
boundary condition: false
type: Species
name: nervonate
has only substance units: false
initial amount: NaN

metaR r2106
reactant: MODEL1310110033#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM cholcoa c
is: CHEBI:57373
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
type: Species
is: HMDB01374
is: SBO:0000247
initial concentration: 1.0
name: choloyl-CoA(4-)
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaM dtmp e
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: dTMP(2-)
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
constant: false
boundary condition: false
is: CHEBI:26999
is: HMDB01227
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_f65f529d_3721_450f_ac82_73fbfe13c381
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: O75355
name: ENTPD3
has only substance units: false
is encoded by: hsa:956
initial concentration: NaN
is: SBO:0000252

metaR ASPTA
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
fast: false
reactant: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110033#
is: SBO:0000176
name: aspartate transaminase
product: MODEL1310110033#

metaR L LACt2r
kinetic law: MODEL1310110033#
name: L-lactate reversible transport via proton symport
is described by: ECO:0000269
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110033#
type: Reaction

metaM atp x
is: CHEBI:57299
is: C00002
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: ATP(4-)
boundary condition: false
initial amount: NaN
is: HMDB00538
type: Species

metaM fadh2 c
has only substance units: false
type: Species
is: CHEBI:58307
initial amount: NaN
constant: false
name: FADH2(2-)
is: HMDB01197
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_fb2d8e06_1b14_42e7_938d_f860c18c08ae
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q9UJS0
constant: false
is: SBO:0000252
is encoded by: hsa:10165
name: SLC25A13
initial amount: NaN

metaM nh4 n
is: HMDB00051
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
initial concentration: 1.0
is: CHEBI:28938
is: SBO:0000247
name: ammonium

metaM lnlc e
has only substance units: false
name: linoleate
is: CHEBI:30245
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: HMDB00673
initial concentration: 1.0

metaR r2107
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110033#
is: SBO:0000185
reversible: true
product: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_bb2cd4a1_ed17_44a3_bb25_818b9189264a
initial concentration: NaN
constant: false
name: SLC25A1
initial amount: NaN
boundary condition: true
type: Species
is: D9HTE9
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6576

metaR MI14Ptn
is: SBO:0000185
type: Reaction
reversible: true
fast: false
product: MODEL1310110033#
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
kinetic law: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110033#

metaM nadph x
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
constant: false
is: C00005

metaR 4NPHSFte
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: true
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
kinetic law: MODEL1310110033#

metaM CE2870 c
is: CHEBI:15374
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 3,3'-diiodo-L-thyronine 4'-O-sulfate
has only substance units: false
notes: FORMULA: C15H12I2NO7S CHARGE: -1 INCHI: InChI=1/C15H13I2NO7S/c16-10-5-8(6-12(18)15(19)20)1-3-13(10)24-9-2-4-14(11(17)7-9)25-26(21,22)23/h1-5,7,12H,6,18H2,(H,19,20)(H,21,22,23)/p-1/t12-/m1/s1 EHMN_ABBREVIATION: CE2870
constant: false
type: Species
is: HMDB02281
initial amount: NaN

metaR TYMSULT
is: SBO:0000176
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
reversible: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: Tyramine Sulfotransferase
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_80710768_f74b_4fa7_a851_d2fb8ed72fc9
is encoded by: hsa:1807
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: Q14117
name: DPYS
initial amount: NaN
is: SBO:0000252

metaR P45027A15m
kinetic law: MODEL1310110033#
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
reversible: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ

http://identifiers.org/biomodels.db/MODEL1310110033#_d6f9ffed_03f0_4dce_8e33_d37d65fe0811
constant: false
is: SBO:0000252
name: _286297_1_c
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:286297

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaR MACACI
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
type: Reaction
modifier: MODEL1310110033#
fast: false
reversible: false
name: maleylacetoacetate isomerase
is: SBO:0000176
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_104e9b3e_1513_4148_ad74_9ea29b336f24
is: SBO:0000252
initial amount: NaN
name: ACO2
is: Q99798
type: Species
initial concentration: NaN
is encoded by: hsa:50
has only substance units: false
boundary condition: true
constant: false

metaM man1p c
type: Species
initial concentration: 1.0
is: CHEBI:35374
initial amount: NaN
is: HMDB06330
constant: false
name: D-Mannose 1-phosphate
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
boundary condition: false
has only substance units: false

metaR BTNPL
reactant: MODEL1310110033#
name: holocarboxylase synthestase (biotin protein ligase)
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
reversible: false
is described by: ECO:0000000

metaM dgdp c
is: CHEBI:58595
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
is: C00361
boundary condition: false
initial concentration: 1.0
is: HMDB00960
initial amount: NaN
has only substance units: false
type: Species
name: dGDP

metaR r2108
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110033#
modifier: MODEL1310110033#

metaR ASAH1
reversible: false
is described by: ECO:0000000
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.5.1.23
kinetic law: MODEL1310110033#
name: N-acylsphingosine amidohydrolase
type: Reaction
fast: false
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176

metaM nh4 m
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
is: HMDB00051
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: C01342
type: Species
boundary condition: false
is: CHEBI:28938

metaR RE3567C
is: SBO:0000176
reactant: MODEL1310110033#
reversible: true
fast: false
kinetic law: MODEL1310110033#
type: Reaction
name: RE3567
is described by: ECO:0000000
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaM 3hmp m
type: Species
is: CHEBI:11805
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoate
is: HMDB00023
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

metaR NMNATn
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1
product: MODEL1310110033#
is: SBO:0000176
reversible: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (64802.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.7.1 Confidence Level: 4 AUTHORS: PMID:11027696,PMID:11248244,PMID:12574164 NOTES:IT
is described by: ECO:0000269
name: nicotinamide-nucleotide adenylyltransferase
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_fa104183_c7b8_4289_92e3_fec6e3abbb7c
has only substance units: false
is: O76062
constant: false
initial concentration: NaN
is encoded by: hsa:7108
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: TM7SF2

http://identifiers.org/biomodels.db/MODEL1310110033#_db2ebd87_1a96_4dc9_8d41_9fbfdf5cadb4
initial concentration: NaN
initial amount: NaN
is: P10768
name: ESD
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2098
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_e99e8416_6b94_4847_906b_ae6814f8e211
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:80201
initial amount: NaN
is: SBO:0000252
name: HKDC1
is: B3KT70
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6285e10f_cbe1_4ddb_b2c2_28c0f1dc7fd1
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:53905
is: SBO:0000252
name: DUOX1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_cd05a309_7b26_46c4_a084_6429144a3fa0
is: E9PAY8
is encoded by: hsa:8612
name: PPAP2C
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r0512
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_be29b00a_af86_46c9_a674_5a570b36d9f7
initial amount: NaN
name: RRM2B
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:50484
initial concentration: NaN
type: Species
is: Q7LG56
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_13b30add_f402_4287_a652_72cdcfce02c8
is: P00558
is encoded by: hsa:5230
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PGK1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_6741da13_a6b4_4b83_ac51_a5b75111e16e
is: Q5QPH3
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:55902
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ACSS2

http://identifiers.org/biomodels.db/MODEL1310110033#_dd7c788f_e832_4eaa_913a_0f65afd69762
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: GGT2
is encoded by: hsa:728441
initial concentration: NaN
initial amount: NaN
type: Species

metaR HSAT1ly
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_888b9b5c_e93a_4115_8b09_ea8e09bd9023
name: ATP2B3
type: Species
initial concentration: NaN
is encoded by: hsa:492
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q16720
constant: false
boundary condition: true

metaM itp n
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
has only substance units: false
name: ITP(3-)
boundary condition: false
is: HMDB00189
is: SBO:0000247
is: CHEBI:57614
initial concentration: 1.0
constant: false
type: Species

metaM atp c
initial amount: NaN
constant: false
initial concentration: 1.0
name: ATP(4-)
is: SBO:0000247
boundary condition: false
is: HMDB00538
is: C00002
is: CHEBI:30616
has only substance units: false
type: Species

metaR GALASE3ly
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110033#_9a3f4e5e_b067_4242_aec6_d42b65e69e0f
initial concentration: NaN
is: E9PB82
type: Species
is encoded by: hsa:3295
initial amount: NaN
is: SBO:0000252
name: HSD17B4
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a2330afc_7068_469b_9325_925f150e40f8
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6817
name: SULT1A1
initial amount: NaN
is: SBO:0000252
is: P50225
boundary condition: true

metaR PPItx
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
product: MODEL1310110033#
is described by: ECO:0000000
name: Diphosphate transporter, peroxisome
is: SBO:0000185
fast: false
kinetic law: MODEL1310110033#
type: Reaction

metaR VALTAm
name: valine transaminase, mitochondiral
reversible: true
reactant: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110033#
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110033#

metaM thp2c c
is: HMDB12130
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:16987
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
name: 1-piperideine-6-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110033#_530316a8_94f1_41b6_aca0_0d8793df0ccc
is encoded by: hsa:4704
is: Q16795
constant: false
initial concentration: NaN
is: SBO:0000252
name: NDUFA9
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaR UGT1A10r
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
product: MODEL1310110033#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
type: Reaction
modifier: MODEL1310110033#
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110033#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.1.17

metaR MGCHrm
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110033#
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM

metaM ha e
initial concentration: 1.0
is: SBO:0000247
name: hyaluronan
type: Species
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16336
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518

metaR CORE2GTg
is: SBO:0000176
fast: false
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.102
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
modifier: MODEL1310110033#
is described by: ECO:0000000
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110033#

metaM f6p c
boundary condition: false
is: CHEBI:57579
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3385
is: HMDB00124
type: Species
constant: false
initial concentration: 1.0
name: D-Fructose 6-phosphate
is: C00085

metaR RE0344C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
name: RE0344
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
reversible: true
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.2.2
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_c71de8e7_a44e_419c_b4cc_5749c50f732a
initial amount: NaN
boundary condition: true
name: DGKB
has only substance units: false
is encoded by: hsa:1607
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6802b75a_d0fc_4184_bc6e_420466dc15ef
type: Species
initial concentration: NaN
is encoded by: hsa:515
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r0963
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reactant: MODEL1310110033#
name: Facilitated diffusion
reversible: false
fast: false
product: MODEL1310110033#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_1001e25e_7932_43b8_bf10_799b4c6a1840
is: Q01959
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6531
name: SLC6A3

metaM dolglcp U r
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:15812
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_59a3af78_0905_4df3_b0b5_e242eae94911
boundary condition: true
constant: false
is encoded by: hsa:AA614647
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _AA614647_1_c
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_22aca1ef_eff0_4be7_8812_63748c4d6255
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: B7Z6S9
has only substance units: false
is encoded by: hsa:2629
name: GBA
initial concentration: NaN

metaM 2mpdhl m
type: Species
name: S-(2-Methylpropanoyl)-dihydrolipoamide
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
is: CHEBI:17577
initial amount: NaN
is: SBO:0000247

metaM gm1 hs g
is: SBO:0000247
type: Species
constant: false
is: CHEBI:18216
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C55H95N3O30FULLRCO CHARGE: -1
name: ganglioside GM1
initial amount: NaN

metaM HC01162 c
initial amount: NaN
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
initial concentration: 1.0
has only substance units: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: CHEBI:58376
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaM dsT antigen g
notes: FORMULA: C36H56N3O26X CHARGE: -2
constant: false
is: CHEBI:16497
boundary condition: false
is: HMDB01440
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
name: disialyl-T antigen

http://identifiers.org/biomodels.db/MODEL1310110033#_8a98aa29_b0d6_455c_9b6c_32a9a93e6117
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:8867
is: O43426
name: SYNJ1
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM ga2 hs g
is: SBO:0000247
name: GA2
is: CHEBI:465284
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
has only substance units: false

metaR RE1532M
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000176
name: RE1532
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110033#
fast: false

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_8ad1bac2_4e2b_454d_ad84_b545fa7cda70
initial amount: NaN
is: P28331
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4719
name: NDUFS1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_8faa5c05_b432_4488_bc35_44285047e85e
is: SBO:0000252
is encoded by: hsa:55568
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: GALNT10
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a818447d_aa39_428b_83d0_c78d126775d7
is encoded by: hsa:112
initial amount: NaN
constant: false
has only substance units: false
name: ADCY6
type: Species
is: SBO:0000252
initial concentration: NaN
is: O43306
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_dd4f81f5_faba_4802_b2c5_e66d7eab220b
is: P51688
constant: false
initial amount: NaN
boundary condition: true
name: SGSH
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:6448

metaR TCHOLAte
is: SBO:0000185
product: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110033#
name: bile acid intracellular transport
kinetic law: MODEL1310110033#

metaM fe3 e
is: CHEBI:29034
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB12943
type: Species
initial concentration: 1.0
has only substance units: false
name: Fe3+

metaM acrn c
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
constant: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
name: O-acetylcarnitine
initial concentration: 1.0
is: CHEBI:57589
is: HMDB00201

metaR ALAtN1
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: Alanine transport (Na, H coupled)
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaM xol27oh m
constant: false
is: SBO:0000247
is: HMDB02103
name: 26-hydroxycholesterol
is: CHEBI:17703
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial concentration: 1.0

metaR ADNCYC
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
is version of: http://identifiers.org/ec-code/4.6.1.1
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
fast: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
name: adenylate cyclase
type: Reaction
is described by: ECO:0000269
reversible: false

metaR MTHFCm
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
is version of: http://identifiers.org/ec-code/6.3.4.3
type: Reaction
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110033#
reversible: true
is: SBO:0000176

metaR RE2349C
name: RE2349
is: SBO:0000176
modifier: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.64
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
fast: false
is described by: ECO:0000000

metaR r2359
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110033#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_40cb72e8_175e_4712_92a7_19e21a5a5206
boundary condition: true
is: Q9NYW8
name: RBAK
is encoded by: hsa:57786
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaM fol e
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00121
has only substance units: false
boundary condition: false
type: Species
name: Folate

metaR URATEt
is described by: ECO:0000000
type: Reaction
name: urate export from cytosol
kinetic law: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_dd2ef367_fee3_45b9_b721_26b121ec53fc
boundary condition: true
name: NDUFB2
is: SBO:0000252
is encoded by: hsa:4708
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: H7C5B8
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_6b790a65_fe84_4f0c_9733_3b0d3c2fab0c
is encoded by: hsa:374291
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: NDUFS7
initial amount: NaN
boundary condition: true
is: O75251

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
product: MODEL1310110033#
is: SBO:0000176
reversible: true
is described by: ECO:0000254

metaM q10 m
is: CHEBI:46245
has only substance units: false
is: HMDB01072
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: SBO:0000247
name: ubiquinone-10
boundary condition: false
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_22ac6637_9998_4329_ba01_f18396f5dabf
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: DGKG
is: P49619
is encoded by: hsa:1608
has only substance units: false

metaM ibcoa m
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
type: Species
name: isobutyryl-CoA(4-)
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB01243
is: CHEBI:57338

metaR S6TASE12ly
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true

metaM acgam r
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
name: N-acetyl-D-glucosamine
is: CHEBI:17411
has only substance units: false

metaM fe3 c
is: SBO:0000247
is: HMDB12943
notes: FORMULA: Fe CHARGE: 3
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: Fe3+
boundary condition: false

metaR DNDPt8m
reversible: false
product: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
name: dADP transport via dUDP antiport
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000185
type: Reaction

metaR AICART
reversible: true
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
type: Reaction
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.1.2.3
kinetic law: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
product: MODEL1310110033#

metaM cs e deg2 l
is: HMDB01354
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
initial concentration: 1.0
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
type: Species
is: SBO:0000247
constant: false
is: CHEBI:57455
boundary condition: false
has only substance units: false

metaR DAGt
name: diacylglycerol transport
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110033#

metaM ha l
is: CHEBI:16336
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
name: hyaluronan

http://identifiers.org/biomodels.db/MODEL1310110033#_ef2a60d0_2ed4_4c68_ae18_33373c100848
is encoded by: hsa:8879
name: SGPL1
is: SBO:0000252
is: O95470
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM ksi deg22 l
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57455
initial concentration: 1.0
is: HMDB01354
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
name: keratan sulfate I, degradation product 22
type: Species
initial amount: NaN
is: SBO:0000247

metaR r2356
kinetic law: MODEL1310110033#
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#

metaM dgtp e
is: HMDB01440
initial amount: NaN
name: dGTP
is: CHEBI:16497
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
type: Species
boundary condition: false

metaR DPCOAK
product: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000269
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.3
is: SBO:0000176
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: dephospho-CoA kinase
fast: false

metaM fol c
initial amount: NaN
constant: false
is: HMDB00121
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
has only substance units: false
name: Folate
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_2ffd2397_ae9a_4203_83a1_68e0832a0804
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:84105
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9H0N5
name: PCBD2

metaM nh4 x
has only substance units: false
is: HMDB00051
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
type: Species
is: CHEBI:28938
initial amount: NaN
name: Ammonium
boundary condition: false
is: C01342

metaR CAt7r
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
name: calcium / sodium antiporter (1:3), reversible
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
fast: false
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_5ef24e86_6739_4bd0_b5ed_8ec44f14257e
is: SBO:0000252
is: A6NN98
type: Species
initial concentration: NaN
initial amount: NaN
name: MTMR2
constant: false
boundary condition: true
is encoded by: hsa:8898
has only substance units: false

metaM HC02208 c
boundary condition: false
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
is: CHEBI:27696
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-d1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_6a705ff5_23bb_46e5_8223_1f6ad3105a3b
is: Q92535
boundary condition: true
name: PIGC
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:5279
initial concentration: NaN

metaR MI134PP
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 1-phosphatase
reactant: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.57
type: Reaction
kinetic law: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110033#

metaR NACHEX22ly
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110033#
type: Reaction

metaR DURAD2
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
fast: false
name: dihydrothymin dehydrogenase (NADP)
reversible: true
product: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#

metaR APOCF
is: SBO:0000176
reversible: false
name: Apocarboxylase formation
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
product: MODEL1310110033#

metaR IDOAASE1ly
modifier: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: alpha-L-iduronidase, lysosomal
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
product: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false

metaR r0670
fast: false
product: MODEL1310110033#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reactant: MODEL1310110033#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110033#
is described by: ECO:0000000
type: Reaction

metaR r2355
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
fast: false
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_8f0d21d1_ef79_4478_b479_db0589bfda9e
initial concentration: NaN
constant: false
is: Q96C36
has only substance units: false
initial amount: NaN
name: PYCR2
is encoded by: hsa:29920
type: Species
boundary condition: true
is: SBO:0000252

metaR DNDPt15m
reactant: MODEL1310110033#
name: dUDP transport via dGDP antiport
fast: false
modifier: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaR r1827
fast: false
reversible: false
modifier: MODEL1310110033#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction

metaM atp m
is: C00002
name: ATP(4-)
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:57299
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00538

metaR ITCOAL1m
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is described by: ECO:0000304
reversible: true

metaR r2358
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_82b2b91a_9166_43f6_aa9d_2142bf63ec0f
has only substance units: false
name: COX7B
is: P24311
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1349
constant: false
boundary condition: true

metaM dgtp c
is: CHEBI:16497
name: dGTP
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00286
is: HMDB01440
has only substance units: false

metaM HC02208 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:27696
name: prostaglandin-d1
constant: false
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_9a54b6c5_c087_429a_9306_9991855780c8
constant: false
is encoded by: hsa:1543
boundary condition: true
is: SBO:0000252
name: CYP1A1
is: A0N0X8
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM retinal cis 9 c
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17898
initial amount: NaN
is: HMDB01358

metaR XYLt
name: D-xylose reversible transport
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
kinetic law: MODEL1310110033#
reversible: true
is described by: ECO:0000269

metaR r2357
reversible: true
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110033#
is described by: ECO:0000000
type: Reaction

metaR PPItm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
product: MODEL1310110033#
name: diphopshate transporter, mitochondrial
is: SBO:0000185
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000134

metaR RE3556C
is: SBO:0000176
name: RE3556
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_f5e927a0_5eb0_4c1d_a7db_8b3bc38fb1e9
initial concentration: NaN
is: SBO:0000252
is: Q6IBC0
type: Species
is encoded by: hsa:3155
name: HMGCL
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR PROSTGI2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is: SBO:0000185
product: MODEL1310110033#
name: Prostaglandin I2 transport
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
reversible: true
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110033#_0b36cc6e_bcc5_47cb_8250_b22dafa4a9e9
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2653
initial amount: NaN
constant: false
boundary condition: true
is: P23434
name: GCSH
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_25f4aa17_109d_494d_8802_7fa09c6dbebf
boundary condition: true
has only substance units: false
name: ALPI
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P09923
type: Species
is encoded by: hsa:248
constant: false

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR PCHOLPm hs
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
name: choline phosphatase
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reversible: false
modifier: MODEL1310110033#

metaM acac x
type: Species
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
initial concentration: 1.0
boundary condition: false
is: CHEBI:13705
is: SBO:0000247
is: HMDB00060
has only substance units: false
constant: false

metaR ACACT5p
fast: false
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
type: Reaction
product: MODEL1310110033#

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_f22d5d73_5589_4262_8475_fc2eb5e31170
is: E2DRY6
is: SBO:0000252
is encoded by: hsa:2023
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: ENO1
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_bffbfb3e_4729_4439_a061_f6e14eb29c04
constant: false
is: SBO:0000252
type: Species
name: _AV717590_1_c
is encoded by: hsa:AV717590
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r2352
is: SBO:0000185
kinetic law: MODEL1310110033#
type: Reaction
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110033#
fast: false
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaM acgam l
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00215
initial amount: NaN
is: CHEBI:17411
boundary condition: false
initial concentration: 1.0
constant: false
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140

http://identifiers.org/biomodels.db/MODEL1310110033#_c5f7edac_a574_42df_b90b_7ed6241fe5d9
type: Species
has only substance units: false
constant: false
name: PNPO
is: SBO:0000252
is encoded by: hsa:55163
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9NVS9

http://identifiers.org/biomodels.db/MODEL1310110033#_86b42e43_6e45_4c04_b3c9_f7034e774c90
type: Species
constant: false
boundary condition: true
is: Q5JWV8
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2182
name: ACSL4

metaM q10 c
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial amount: NaN
name: ubiquinone-10
is: CHEBI:46245
initial concentration: 1.0
is: HMDB01072
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species

metaM cholcoa r
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: CHEBI:57373
is: HMDB01374
initial concentration: 1.0
name: choloyl-CoA(4-)
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_95035fc8_b939_4549_a9ca_e26ee189a886
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P30838
is encoded by: hsa:218
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: ALDH3A1

http://identifiers.org/biomodels.db/MODEL1310110033#_b66802ef_c722_40cd_8c3c_98e1ae32ac02
type: Species
name: LDHD
is: SBO:0000252
boundary condition: true
is encoded by: hsa:197257
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaR CYTK10n
name: cytidylate kinase (CMP,dGTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110033#
type: Reaction
reversible: true
modifier: MODEL1310110033#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_5d4ea9b2_3f97_4bef_9532_f1b00344d2c4
is encoded by: hsa:3712
type: Species
initial concentration: NaN
is: B3KVI7
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: IVD

http://identifiers.org/biomodels.db/MODEL1310110033#_57a6c80f_7cf3_4f1e_bc00_a95aaa8a7c39
initial concentration: NaN
is encoded by: hsa:5214
constant: false
name: PFKP
is: SBO:0000252
type: Species
is: Q5VSR7
has only substance units: false
boundary condition: true
initial amount: NaN

metaR P5CR
name: pyrroline-5-carboxylate reductase
type: Reaction
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
reversible: false

metaR RE3050R
type: Reaction
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
name: RE3050
kinetic law: MODEL1310110033#

metaM atp e
initial amount: NaN
is: C00002
is: CHEBI:57299
is: HMDB00538
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: ATP(4-)
boundary condition: false
constant: false

metaM sphings c
initial concentration: 1.0
is: CHEBI:57756
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: HMDB00252
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
name: sphingosine(1+)

http://identifiers.org/biomodels.db/MODEL1310110033#_b735dccf_7ced_4349_94fd_829a381f67eb
type: Species
initial amount: NaN
name: CYP24A1
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:1591
initial concentration: NaN
is: Q07973

metaR r0960
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_fc973540_e73e_4a04_a90c_502d741b2a58
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: _PRO1933_1_m
is encoded by: hsa:PRO1933
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM dc2coa m
constant: false
boundary condition: false
is: CHEBI:61406
name: trans-Dec-2-enoyl-CoA
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275

http://identifiers.org/biomodels.db/MODEL1310110033#_0875d46d_7b79_4d9a_8186_9fafcfd1ff8e
has only substance units: false
type: Species
initial concentration: NaN
is: F8W7V3
is: SBO:0000252
constant: false
name: ATP5J2
is encoded by: hsa:9551
boundary condition: true
initial amount: NaN

metaR r2354
reactant: MODEL1310110033#
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
type: Reaction

metaR EX cholate LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholate
type: Reaction

metaM h2o2 x
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: HMDB03125
initial concentration: 1.0
name: Hydrogen peroxide
constant: false
type: Species
is: CHEBI:16240
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM ksii core2 e
name: keratan sulfate II (core 2-linked)
is: HMDB00211
constant: false
type: Species
is: CHEBI:17268
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial concentration: 1.0

metaM ethamp c
type: Species
initial concentration: 1.0
is: HMDB00224
is: SBO:0000247
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
name: ethamp[c]
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:58190

metaM q10 e
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false
name: ubiquinone-10
is: HMDB01072
initial concentration: 1.0
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: SBO:0000247
is: CHEBI:46245

http://identifiers.org/biomodels.db/MODEL1310110033#_47bd7b78_0f5c_40cc_857c_d895875371a6
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80025
name: PANK2
type: Species
initial amount: NaN
initial concentration: NaN

metaR VD3
is described by: ECO:0000134
reversible: true
name: Vitamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is: SBO:0000176
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
fast: false

metaR r1821
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false

metaR PPItr
type: Reaction
reactant: MODEL1310110033#
name: Diphosphate transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_163b280f_b2bb_4b1e_bb74_43f4d591575f
is: Q6P4B4
has only substance units: false
initial concentration: NaN
name: PFAS
is encoded by: hsa:5198
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR 4PYRDX
reactant: MODEL1310110033#
type: Reaction
name: 4-Pyridoxal secretion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
reversible: false
product: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
fast: false

metaR r2353
type: Reaction
product: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000

metaM HC00695 m
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
has only substance units: false
constant: false
name: S-Succinyldihydrolipoamide
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17432

metaR RPE
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.1
name: ribulose 5-phosphate 3-epimerase
is: SBO:0000176
modifier: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#

metaM Rtotal3 e
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: R total 3 position
has only substance units: false
is: C00255
is: CHEBI:3554
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: HMDB00244
initial amount: NaN

metaM cmpacna c
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
is: CHEBI:57812
is: SBO:0000247

metaR 3MOPte
kinetic law: MODEL1310110033#
fast: false
reversible: true
product: MODEL1310110033#
name: Transport of 3-methyl-2-oxopentanoate
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_22499666_c830_47e7_bed1_26ed5b49e297
boundary condition: true
constant: false
is: B7Z6M3
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: DGKZ
is: SBO:0000252
is encoded by: hsa:8525

metaR GLYPHEHYc
fast: false
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
reversible: true
is: SBO:0000176
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000134
name: hydrolysis of glycylphenylalanine

metaR GALGT2
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: Beta-1,4 N-acetylgalactosaminyltransferase
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.1.92
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ

metaR r0652
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110033#
fast: false
type: Reaction
modifier: MODEL1310110033#

metaM nadh m
is: HMDB01487
initial amount: NaN
is: C00004
constant: false
is: SBO:0000247
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced

http://identifiers.org/biomodels.db/MODEL1310110033#_f0d1b1b2_8619_4aa4_87fc_8c69f6fcb998
constant: false
initial amount: NaN
is encoded by: hsa:114134
is: SBO:0000252
is: Q96QE2
type: Species
has only substance units: false
initial concentration: NaN
name: SLC2A13
boundary condition: true

metaM arachdcoa c
has only substance units: false
is: CHEBI:57368
is: HMDB06523
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)
constant: false
boundary condition: false
type: Species

metaR r0753
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110033#_81671a29_e328_4312_b7ac_f854ece64e0e
type: Species
name: _AI684467_1_m
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI684467
is: SBO:0000252
constant: false
boundary condition: true

metaM gd1a hs g
name: N-acetylneuraminosyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminosyl)-D-galactosyl-D-glucosylceramide dianion
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58397
type: Species
is: SBO:0000247
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110033#_c91998db_50cf_40b9_a0b5_a2f6b94aac7d
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7378
initial amount: NaN
name: UPP1

http://identifiers.org/biomodels.db/MODEL1310110033#_ca74fde1_6b11_4e53_ba22_9a0d2d720e65
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:513
name: ATP5D
boundary condition: true

metaR RE2814M
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
fast: false
reactant: MODEL1310110033#
type: Reaction
name: RE2814
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_5129352d_07e0_470a_8cb2_02ff8b0d2777
name: ACP6
is encoded by: hsa:51205
boundary condition: true
type: Species
is: Q9NPH0
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR GALGT1
is version of: http://identifiers.org/ec-code/2.4.1.92
is described by: ECO:0000269
is: SBO:0000176
name: Beta-1,4 N-acetylgalactosaminyltransferase
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877,PMID:8702839 NOTES:NJ
reversible: false
modifier: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#

metaR r0653
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110033#
reversible: false
type: Reaction
reactant: MODEL1310110033#

metaM cs b deg3 l
is: CHEBI:21338
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
boundary condition: false
is: HMDB02704
has only substance units: false

metaR UMPK5n
modifier: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dATP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
kinetic law: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
product: MODEL1310110033#

metaR r0754
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
modifier: MODEL1310110033#
type: Reaction
reversible: true
fast: false
product: MODEL1310110033#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_f579b787_1480_406a_ad11_8c2f6b2774d1
constant: false
is encoded by: hsa:515
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ATP5F1

http://identifiers.org/biomodels.db/MODEL1310110033#_547a2fda_9619_45f3_95d4_4b7399699941
is encoded by: hsa:AA977580
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _AA977580_1_c
type: Species
has only substance units: false

metaM hs deg24 l
boundary condition: false
name: GlcNAc-GlcA-(Gal)2-Xyl
notes: FORMULA: C31H50NO26 CHARGE: -1
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:16126
initial amount: NaN
constant: false

metaR ACCOAC
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_884b522e_52b7_4a39_b3e9_820de6cd0663
name: DEGS1
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8560
has only substance units: false

metaR RDH1
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
modifier: MODEL1310110033#
name: retinol dehydrogenase (all-trans)
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
product: MODEL1310110033#

metaR r0650
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110033#
reversible: true

metaR GLB1
name: Beta-galactosidase
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110033#_fd485477_4837_4b92_b700_0e843587b863
is: Q6IB80
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: NDUFB3
initial concentration: NaN
is encoded by: hsa:4709
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_d3f680a5_277c_4666_83dd_87fd4564605e
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:1841
name: DTYMK
is: P23919
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR PFK
is version of: http://identifiers.org/ec-code/2.7.1.11
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110033#
name: phosphofructokinase

http://identifiers.org/biomodels.db/MODEL1310110033#_84f387d9_2363_4f18_9767_0f4b4f3b3da5
is: SBO:0000252
is: Q5MY95
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:377841
initial concentration: NaN
name: ENTPD8
initial amount: NaN

metaR GALGT4
is described by: ECO:0000269
reversible: false
is: SBO:0000176
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
name: Beta-1,4 N-acetylgalactosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.92
fast: false

metaR S6TASE8ly
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110033#

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM 4nphsf c
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06492
is: CHEBI:35422
name: 4-Nitrophenyl sulfate

metaR RDH2
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
modifier: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
name: retinol dehydrogenase (9-cis,NADH)
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000269

metaR PVD3
fast: false
is: SBO:0000176
product: MODEL1310110033#
reversible: true
name: Previtamin D3 formation
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110033#

metaR r0651
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
modifier: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_cde8b234_674b_470c_b81e_b9fce0af394e
initial amount: NaN
is: P23378
is: SBO:0000252
boundary condition: true
constant: false
name: GLDC
is encoded by: hsa:2731
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_ec0e6024_a278_4948_92d8_ffa56f73cb5e
boundary condition: true
initial amount: NaN
is encoded by: hsa:6517
type: Species
constant: false
name: SLC2A4
is: SBO:0000252
has only substance units: false
is: P14672
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_cab736f5_a654_47de_859b_df338bd36ac1
is: Q9Y617
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:29968
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PSAT1

metaR GALGT3
is described by: ECO:0000269
kinetic law: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.92
reactant: MODEL1310110033#
type: Reaction
name: Beta-1,4 N-acetylgalactosaminyltransferase
product: MODEL1310110033#
fast: false
reversible: false
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2583.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.92 Confidence Level: 4 AUTHORS: PMID:1601877 NOTES:NJ

metaM sbt D c
has only substance units: false
name: D-glucitol
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: HMDB00247
initial amount: NaN
is: CHEBI:17924
constant: false
type: Species
initial concentration: 1.0

metaR S2TASE1ly
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reactant: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110033#
product: MODEL1310110033#
name: iduronate-2-sulfatase, lysosomal
fast: false

metaM lnlncgcoa c
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06368
is: CHEBI:57363
type: Species
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
name: gamma-linolenoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110033#_f9131e95_1a28_4f57_8de7_4f46493cffc4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55191
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
is: Q6IA69
name: NADSYN1
boundary condition: true

metaR r0752
kinetic law: MODEL1310110033#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110033#
reversible: true
product: MODEL1310110033#
fast: false
type: Reaction
is: SBO:0000176

metaM 5hoxindact c
is: HMDB04073
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:50157
boundary condition: false
notes: FORMULA: C10H9NO2 CHARGE: 0 INCHI: InChI=1S/C10H9NO2/c12-4-3-7-6-11-10-2-1-8(13)5-9(7)10/h1-2,4-6,11,13H,3H2 HEPATONET_1.0_ABBREVIATION: HC01536 EHMN_ABBREVIATION: C05634
is: SBO:0000247
name: (5-hydroxyindol-3-yl)acetaldehyde
has only substance units: false

metaM idp e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03335
name: IDP(3-)
is: CHEBI:58280
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaM dopa c
is: HMDB00073
constant: false
initial concentration: 1.0
boundary condition: false
name: dopaminium(1+)
has only substance units: false
is: CHEBI:59905
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
type: Species

metaM sphmyln hs c
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58216
name: sphingomyelin betaine
constant: false
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaM nrpphrsf e
type: Species
name: Sulfate derivative of norepinephrine
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/123747
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB02062

metaM ura c
is: HMDB00300
is: C00106
name: Uracil
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaR FADtx
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: FAD transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
product: MODEL1310110033#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110033#

metaR CGLYt3 2
reversible: false
kinetic law: MODEL1310110033#
is described by: ECO:0000304
type: Reaction
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
name: Cys-Gly transport in via proton symport
reactant: MODEL1310110033#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_45056688_0352_47a4_ac3f_9a6cd1b09a1c
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:128869
type: Species
is: Q9H490
is: SBO:0000252
has only substance units: false
constant: false
name: PIGU

metaR 5MTHFt
is: SBO:0000185
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
modifier: MODEL1310110033#
is described by: ECO:0000269

metaR r2361
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110033#
is: SBO:0000185
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaR r0656
reversible: false
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_64abea7e_25f2_4e66_9369_c1024a2fe82d
is: B7Z428
constant: false
boundary condition: true
name: GNE
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:10020
initial amount: NaN

metaR CSAPASEly
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
is: SBO:0000176
reversible: false
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a49f43c0_842b_4524_9b2f_287806637484
initial amount: NaN
type: Species
initial concentration: NaN
is: Q15147
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5332
constant: false
boundary condition: true
name: PLCB4

metaR r2435
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
reversible: false
is: SBO:0000185

metaR r0750
is described by: ECO:0000000
reactant: MODEL1310110033#
reversible: true
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is: SBO:0000176
modifier: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a0bcc4a4_1af6_49b8_b7f8_dcfe6391086d
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ZADH2
is encoded by: hsa:284273
is: Q4G1C4
constant: false

metaM sbt D e
initial concentration: 1.0
name: D-glucitol
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: HMDB00247
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false

metaR r2362
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110033#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

metaM dopa e
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:59905
name: dopaminium(1+)
type: Species

metaR PAPtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: adenosine 3',5'-bisphosphate Golgi transport
fast: false
kinetic law: MODEL1310110033#
reversible: false
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_8a081c22_1ed6_40fc_aab2_52f041d74d22
is: SBO:0000252
initial amount: NaN
name: AICDA
boundary condition: true
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: Q546Y9
is encoded by: hsa:57379

metaR NACHEX11ly
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR GLYt2r
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
name: glycine reversible transport via proton symport
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f3348bc0_8f87_427d_b62a_eabc95a14859
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P35790
is encoded by: hsa:1119
initial amount: NaN
constant: false
name: CHKA
type: Species
has only substance units: false

metaM 2obut m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
name: 2-oxobutanoate
is: HMDB00005
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16763
type: Species

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR MDH
is: SBO:0000176
reactant: MODEL1310110033#
type: Reaction
fast: false
name: malate dehydrogenase
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (130752.1) or (4190.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:Biochemical
is described by: ECO:0000134
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.37
reversible: true
product: MODEL1310110033#

metaM nrpphrsf c
is: HMDB02062
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/123747
name: Sulfate derivative of norepinephrine

http://identifiers.org/biomodels.db/MODEL1310110033#_0fbb7b2d_93e1_4ab2_a7cd_a7ab01f9b49b
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2819
constant: false
is: F8W1L5
name: GPD1

metaR GLCt1r
fast: false
name: glucose transport (uniport)
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
reactant: MODEL1310110033#

metaR Rtotaltl
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
name: fatty acid intracellular transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
kinetic law: MODEL1310110033#

metaR r0549
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.5.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
modifier: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
reversible: true
type: Reaction

metaM idp c
initial amount: NaN
type: Species
is: HMDB03335
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
initial concentration: 1.0
name: IDP(3-)
is: CHEBI:58280

metaM CE2705 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
has only substance units: false
is: SBO:0000247
is: HMDB02281
type: Species
initial concentration: 1.0
name: quinonoid dihydrobiopterin
initial amount: NaN
is: CHEBI:15374
constant: false
boundary condition: false

metaM ahcys m
is: CHEBI:16680
is: C00021
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00939
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
type: Species

metaR RE2814R
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110033#
name: RE2814
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
reversible: true
is: SBO:0000176

metaM nadh r
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB01487
is: CHEBI:57945
is: SBO:0000247
name: NADH(2-)
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004

metaM ura e
name: uracil
is: SBO:0000247
is: HMDB00300
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17568
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR r2433
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: false
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3

http://identifiers.org/biomodels.db/MODEL1310110033#_72d768f6_4049_4f47_9c8c_6926f79f8c66
is: SBO:0000297
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4831
initial amount: NaN
constant: false
has part: P15531
name: NME1:NME2
is encoded by: hsa:4830
has only substance units: false
has part: P22392

metaR r2360
reactant: MODEL1310110033#
reversible: true
is: SBO:0000185
product: MODEL1310110033#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport

metaR ARACHDt2
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
product: MODEL1310110033#

metaR LINOFATPtc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR r0655
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
fast: false
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_75476d50_d61f_42a4_a927_32af453459f9
is encoded by: hsa:5315
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P14618
initial concentration: NaN
name: PKM2
has only substance units: false
constant: false
type: Species

metaM cs b l
initial amount: NaN
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: SBO:0000247
has only substance units: false
is: CHEBI:36005
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
type: Species
initial concentration: 1.0
constant: false
is: HMDB02183

metaM mi134p c
is: CHEBI:58414
is: HMDB01143
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243

http://identifiers.org/biomodels.db/MODEL1310110033#_76e7687d_63e8_4280_aecd_5267c57fd256
is encoded by: hsa:9061
is: O43252
type: Species
boundary condition: true
has only substance units: false
name: PAPSS1
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR r0547
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110033#
reversible: true
fast: false
type: Reaction
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5

metaR MCLOR
kinetic law: MODEL1310110033#
type: Reaction
fast: false
modifier: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
name: 3-Mercaptolactate:NAD+ oxidoreductase
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110033#_70d36902_a782_4c02_a9dc_095c31798de6
is: SBO:0000252
name: CLYBL
initial concentration: NaN
is encoded by: hsa:171425
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaM tststerone r
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
name: testosterone
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB00234
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_da5efc1f_db0a_4051_83f9_6892f2e0f893
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:3251
boundary condition: true
constant: false
initial concentration: NaN
name: HPRT1
is: P00492
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_0d0b404d_26c3_49fd_92bf_bef21c314da5
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:55825
constant: false
is: Q9BY49
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PECR

http://identifiers.org/biomodels.db/MODEL1310110033#_f9647f59_8a58_49f5_bcd9_3646fce2edb8
initial concentration: NaN
is encoded by: hsa:3284
initial amount: NaN
boundary condition: true
name: HSD3B2
constant: false
type: Species
is: P26439
has only substance units: false
is: SBO:0000252

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaM ksi deg2 l
is: HMDB01356
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
has only substance units: false
is: SBO:0000247
is: CHEBI:57312
type: Species
name: keratan sulfate I, degradation product 2
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR S6TASE2ly
kinetic law: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR ALOX5
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
is described by: ECO:0000269
type: Reaction
name: Arachidonate 5-lipoxygenase
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.34
reactant: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
fast: false

metaM ttdca e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C06424
is: CHEBI:30807
initial amount: NaN
constant: false
name: tetradecanoate (n-C14:0)
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: HMDB00806
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_61065301_6418_4c05_9016_ad516e6b0cfc
boundary condition: true
is: SBO:0000252
type: Species
name: ACAA1
has only substance units: false
is: Q96CA6
initial amount: NaN
is encoded by: hsa:30
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_3b9eb6c2_f9d2_4726_b11e_f57b8458ea27
constant: false
name: DLD:DLST:OGDH:PDHX
is: SBO:0000297
has part: B4E3E9
is encoded by: hsa:4967
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species

metaM bilglcur e
boundary condition: false
has only substance units: false
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
constant: false
is: CHEBI:57767
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaM dump c
type: Species
initial amount: NaN
is: HMDB01409
name: dUMP
is: C00365
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
is: CHEBI:246422
constant: false
boundary condition: false
has only substance units: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR MTHFD2
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD)
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000134
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
reactant: MODEL1310110033#
product: MODEL1310110033#

metaR IDOAASE2ly
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.76
product: MODEL1310110033#

metaR CAATPS
is: SBO:0000185
modifier: MODEL1310110033#
is described by: ECO:0000269
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
name: Ca ATPase
type: Reaction
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.6.3.8
fast: false
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ

metaM ksi deg37 l
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C62H104N4O46 CHARGE: 0
initial amount: NaN
constant: false
name: keratan sulfate I, degradation product 37
boundary condition: false
is: HMDB01354
is: CHEBI:57455
type: Species

metaR CHOLATEt
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
is: SBO:0000185
modifier: MODEL1310110033#
fast: false
name: cholate transport via bicarbonate countertransport
product: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_f2bef1ca_186f_400c_adbd_a6b967432ff5
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:54576
constant: false
boundary condition: true
has only substance units: false
is: Q5DSZ6
initial concentration: NaN
name: UGT1A8

metaR 24 25DHVITD3tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: 24,25-Dihydroxyvitamin D3 transport from mitochondria
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_020b0c2b_6308_4f2f_8fbd_ec8f9adcdc85
type: Species
initial amount: NaN
is encoded by: hsa:1329
initial concentration: NaN
name: COX5B
is: Q53YB7
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaR r0545
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_c7331c84_bcf6_493e_9e7d_cf17da0d7e36
constant: false
is encoded by: hsa:AA629629
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AA629629_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_1bb981e5_e839_410b_8655_08c8b325e9b3
has only substance units: false
is: Q04760
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2739
name: GLO1
initial concentration: NaN

metaM cmpacna n
initial concentration: 1.0
constant: false
type: Species
is: HMDB01176
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
boundary condition: false
initial amount: NaN

metaM triodthy c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: 3,3',5-triiodo-L-thyronine
initial concentration: 1.0
type: Species
is: CHEBI:18258
is: HMDB00265

metaM 2mb2coa m
is: CHEBI:57337
initial concentration: 1.0
is: HMDB02054
name: 2-methylcrotonoyl-CoA(4-)
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR B3GALT5g
reversible: false
fast: false
modifier: MODEL1310110033#
type: Reaction
name: Beta-1,3-galactosyltransferase 5
is: SBO:0000176
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110033#
is described by: ECO:0000269

metaR CITtbm
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
is: SBO:0000185
type: Reaction
reversible: true
name: citrate transport, mitochondrial

metaR PRAGSr
kinetic law: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.2
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: phosphoribosylglycinamide synthase
reversible: true
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
is described by: ECO:0000269

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaM pa hs c
boundary condition: false
initial concentration: 1.0
is: CHEBI:57739
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial amount: NaN
name: phosphatidate(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a467983f_4600_41c4_9f07_20d8e643ad28
is: SBO:0000252
is encoded by: hsa:6120
boundary condition: true
is: Q53TV9
has only substance units: false
constant: false
name: RPE
type: Species
initial amount: NaN
initial concentration: NaN

metaM ptrc e
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01414
is: C00134
is: CHEBI:326268
initial concentration: 1.0
name: Putrescine
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_2a74dc13_c8e9_41f5_a33a_39fc4361855a
constant: false
initial concentration: NaN
is: SBO:0000252
is: P04035
is encoded by: hsa:3156
has only substance units: false
name: HMGCR
initial amount: NaN
type: Species
boundary condition: true

metaM lpchol hs e
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: CHEBI:60479
name: lysophosphatidylcholine
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6f1efd40_0cb3_42e3_8503_a9992ca162ec
constant: false
is: SBO:0000252
initial amount: NaN
name: _AA419122_1_c
boundary condition: true
type: Species
is encoded by: hsa:AA419122
has only substance units: false
initial concentration: NaN

metaM bilglcur c
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:57767
initial concentration: 1.0
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

http://identifiers.org/biomodels.db/MODEL1310110033#_0a14ddec_25cb_433d_af59_b40427559743
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
has part: Q6IB54
is encoded by: hsa:522
initial amount: NaN

metaR RE3566C
reversible: true
type: Reaction
name: RE3566
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110033#

metaR GMPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
reversible: true
name: GMP transport (Golgi)
kinetic law: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_9cc905d4_69dd_45d4_acf0_7994af524fb5
type: Species
initial amount: NaN
is encoded by: hsa:J03866
name: _J03866_1_m
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaM dcyt n
constant: false
is: CHEBI:15698
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 2'-deoxycytidine
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: HMDB00014

metaR r0757
is described by: ECO:0000000
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
reversible: true
reactant: MODEL1310110033#
fast: false
type: Reaction
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110033#
is: SBO:0000176

metaR TDCHOLAte
reactant: MODEL1310110033#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
fast: false

metaR EX lpchol hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lysophosphatidylcholine
type: Reaction

metaM HC01522 c
initial concentration: 1.0
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
name: Gentisate aldehyde
type: Species
constant: false
is: CHEBI:28508
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM pcrn x
constant: false
is: http://identifiers.org/pubchem.compound/107738
has only substance units: false
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
initial amount: NaN
is: HMDB00824
initial concentration: 1.0
type: Species
is: SBO:0000247
name: propionyl-carnitine

metaM CE2705 c
is: CHEBI:30623
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
name: quinonoid dihydrobiopterin
constant: false
type: Species
is: HMDB02329
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM HC00591 c
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16769
is: SBO:0000247
has only substance units: false
name: 2-oxoglutaramate

metaM lnlncgcoa r
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
is: HMDB06368

metaM triodthy e
constant: false
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: 3,3',5-triiodo-L-thyronine
is: CHEBI:18258
is: HMDB00265
initial concentration: 1.0

metaM cmpacna g
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
constant: false
is: CHEBI:57812
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false

metaR r0758
kinetic law: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
name: 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
type: Reaction
product: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:8155713,PMID:8605195 NOTES:

metaR TSTSTERONEt
reactant: MODEL1310110033#
fast: false
name: Testosterone transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true

metaR r0330
reversible: false
kinetic law: MODEL1310110033#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
fast: false
is described by: ECO:0000000
modifier: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_6aee8aa9_0e6c_4ced_8343_ef4b62ee8704
type: Species
initial concentration: NaN
is: SBO:0000252
is: P82251
initial amount: NaN
boundary condition: true
is encoded by: hsa:11136
constant: false
name: SLC7A9
has only substance units: false

metaR RBFK
name: riboflavin kinase
is described by: ECO:0000269
modifier: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.26
reversible: false
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

metaM nadh x
is: SBO:0000247
is: HMDB01487
constant: false
is: CHEBI:57945
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
is: C00004
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide - reduced
type: Species

metaR r0755
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110033#
reversible: true
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:

metaR HS2ly
reversible: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
kinetic law: MODEL1310110033#
name: heparan-N-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.10.1.1
modifier: MODEL1310110033#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000

metaM sucsal m
name: Succinic semialdehyde
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
constant: false
boundary condition: false
is: CHEBI:57706
has only substance units: false
is: HMDB01259
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM ksi deg21 l
is: HMDB00143
constant: false
has only substance units: false
type: Species
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 21
is: CHEBI:12936
boundary condition: false

metaR r0541
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is: SBO:0000176
reversible: true
is described by: ECO:0000000
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#

metaR PGMT
fast: false
name: phosphoglucomutase
modifier: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/5.4.2.2
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000134

metaM gm1b hs g
boundary condition: false
name: GM1b
type: Species
is: HMDB00256
notes: FORMULA: C55H95N3O30FULLRCO CHARGE: -1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:15440
is: SBO:0000247

metaR GALASE18ly
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110033#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
reversible: false

metaR r0756
reversible: true
notes: GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
is: SBO:0000176
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaM pydam c
is: HMDB01431
is: SBO:0000247
constant: false
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
is: C00534
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
name: Pyridoxamine
is: CHEBI:57761

http://identifiers.org/biomodels.db/MODEL1310110033#_38649b4c_7e4e_4461_8a99_68228fc824e4
type: Species
is encoded by: hsa:4731
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P56181
boundary condition: true
name: NDUFV3
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_c0cb24f4_d408_4b6b_8e72_a8b2963256fd
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: SLC25A1
is encoded by: hsa:6576
constant: false
is: D9HTE9

metaR PI345P5P
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000176
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_eb4dac40_6b63_47d3_8111_ad4bab7082c4
is encoded by: hsa:498
name: ATP5A1
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is: B4DY56
type: Species
has only substance units: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR CERT1rt
name: ceramide transport protein
reactant: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
reversible: true
is: SBO:0000185
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110033#_cea911a9_4d52_4c58_bfff_b7ea06f39493
is: Q9BZV2
type: Species
constant: false
initial amount: NaN
name: SLC19A3
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:80704
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_06d3d46a_56c5_4444_b572_5815bfbb44f4
type: Species
initial amount: NaN
name: _AI345944_1_m
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:AI345944

metaR S4TASE1ly
reversible: true
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
type: Reaction

metaR GLCNACASE4ly
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110033#

metaR RE1518M
fast: false
reversible: true
kinetic law: MODEL1310110033#
is: SBO:0000176
type: Reaction
name: RE1518
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110033#
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_4cf132b6_d63c_4117_b424_7add1e6ca3da
initial concentration: NaN
type: Species
is encoded by: hsa:159
constant: false
is: SBO:0000252
is: P30520
has only substance units: false
boundary condition: true
initial amount: NaN
name: ADSS

metaM pa hs n
name: phosphatidate(2-)
is: SBO:0000247
is: CHEBI:57739
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

metaM gua e
boundary condition: false
name: guanine
is: CHEBI:16235
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00132
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242

metaM galside hs l
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: D-galactosyl-N-acylsphingosine

metaR r0552
is version of: http://identifiers.org/ec-code/1.3.5.1
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
kinetic law: MODEL1310110033#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
modifier: MODEL1310110033#

metaR r1608
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false

metaM 2obut c
type: Species
is: CHEBI:16763
is: SBO:0000247
name: 2-Oxobutanoate
initial concentration: 1.0
is: C00109
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
constant: false
is: HMDB00005
initial amount: NaN
has only substance units: false
boundary condition: false

metaR NTD10
product: MODEL1310110033#
reversible: false
is: SBO:0000176
reactant: MODEL1310110033#
is described by: ECO:0000254
type: Reaction
name: 5'-nucleotidase (XMP)
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false

metaM cholp c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: SBO:0000247
initial amount: NaN
name: choline phosphate(1-)
boundary condition: false
constant: false
is: CHEBI:295975
type: Species

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR PE HStm
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110033#
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
fast: false

metaR r1929
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
reversible: false
name: Y+LAT2 Utilized transport
fast: false
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#

metaM pcrn m
is: http://identifiers.org/pubchem.compound/107738
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: HMDB00824
is: SBO:0000247
name: propionyl-carnitine
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaM pa hs m
is: SBO:0000247
is: CHEBI:57739
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
type: Species
constant: false
name: phosphatidate(2-)
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_9b0ed514_4e89_4134_9165_7916a3b6bc68
constant: false
initial concentration: NaN
name: SLC2A7
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q6PXP3
is encoded by: hsa:155184

metaR r1609
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true

metaM 44mzym r
has only substance units: false
is: HMDB01286
is: CHEBI:18364
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
constant: false
name: 14-demethyllanosterol
initial amount: NaN
boundary condition: false

metaM hestratriol e
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
name: 4,17 dihydroxy estradiol
type: Species
initial concentration: 1.0
is: HMDB05896

metaM 4pyrdx c
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: 4-pyridoxate
is: CHEBI:30959
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
initial amount: NaN
initial concentration: 1.0
is: HMDB00017
has only substance units: false

metaR EX hyptaur LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hypotaurine
type: Reaction

metaM gthrd c
constant: false
name: Reduced glutathione
is: C00051
initial concentration: 1.0
boundary condition: false
is: HMDB00125
has only substance units: false
is: SBO:0000247
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
initial amount: NaN

metaR S3TASE3ly
name: N-acetylglucosamine-3-sulfatase, lysosomal
reversible: true
is: SBO:0000176
reactant: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110033#
fast: false
type: Reaction
product: MODEL1310110033#

metaM idp n
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
name: IDP(3-)
initial amount: NaN
is: CHEBI:58280
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB03335
type: Species

metaM dgdp m
constant: false
is: HMDB00960
initial concentration: 1.0
is: SBO:0000247
name: dGDP(2-)
is: CHEBI:58595
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
has only substance units: false
type: Species

metaR r1606
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

metaR LINKDEG4ly
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
reversible: false
type: Reaction
product: MODEL1310110033#
reactant: MODEL1310110033#

metaM Lcyst c
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: L-cysteate(1-)
initial amount: NaN
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
is: HMDB02757
is: CHEBI:58090
constant: false
initial concentration: 1.0

metaR CMPACNAtn
reactant: MODEL1310110033#
name: CMP-Sia nuclear export
reversible: false
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#

metaR Coqe
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
name: Transport of q10
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaR DNDPt27m
reversible: false
modifier: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110033#
name: dCDP transport via dTDP antiport

http://identifiers.org/biomodels.db/MODEL1310110033#_933144f6_bcb3_49b5_bffc_139d2b5060d6
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: P05187
is encoded by: hsa:250
is: SBO:0000252
constant: false
name: ALPP

metaM dgdp n
is: CHEBI:58595
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: dGDP(2-)
type: Species
is: HMDB00960
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_2d821c30_95c6_4c59_9959_ea60529e7921
initial concentration: NaN
type: Species
is: F8WDN9
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:27068
initial amount: NaN
is: SBO:0000252
name: PPA2

metaR r1607
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000185
product: MODEL1310110033#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_94f6062e_fd26_49b7_848d_2db8411c3806
name: GAL3ST1
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:9514
is: Q99999
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaM gthrd e
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
name: glutathionate(1-)
is: CHEBI:57925
is: SBO:0000247

metaR CHSTEROLt3
reversible: true
product: MODEL1310110033#
is described by: ECO:0000000
name: cholesterol intracellular transport
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_829be697_8471_4633_9bf6_71fce8e807c4
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:27165
has only substance units: false
name: GLS2
initial concentration: NaN
initial amount: NaN
is: Q9UI32

metaM hestratriol c
is: HMDB05896
has only substance units: false
initial amount: NaN
name: 4,17 dihydroxy estradiol
boundary condition: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR CHATn
name: Choline O-acetyltransferase
fast: false
product: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.6
kinetic law: MODEL1310110033#
reversible: true

metaM retinal 11 cis c
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:16066
initial amount: NaN
name: 11-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: HMDB02152

metaM met L e
is: CHEBI:16643
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
constant: false
is: HMDB00696
type: Species
boundary condition: false
name: L-methionine
initial concentration: 1.0
has only substance units: false

metaR RE1531M
kinetic law: MODEL1310110033#
fast: false
reversible: true
name: RE1531
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
product: MODEL1310110033#

metaR GLACter
is described by: ECO:0000000
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
is: SBO:0000185
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaM HC00319 c
is: SBO:0000247
constant: false
is: CHEBI:30794
initial concentration: 1.0
name: Malonate
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

metaR SUCCOAPET
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_db3dd027_511b_48f3_8730_82ca3ce2af57
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:115286
boundary condition: true
initial concentration: NaN
is: F8WAB8
name: SLC25A26
type: Species

metaR r1604
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_d0265b72_3adc_4e79_86c5_27e8ff1f91ec
initial amount: NaN
constant: false
is: Q7LG56
name: RRM2B
has only substance units: false
initial concentration: NaN
is encoded by: hsa:50484
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_0622c185_f44a_4f43_bd53_8053e3b7bed1
is: Q70HW3
initial concentration: NaN
is encoded by: hsa:115286
name: SLC25A26
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR r1925
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000185
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110033#_f2945140_a435_419f_a93c_63754d42a701
is encoded by: hsa:10786
has only substance units: false
constant: false
is: O00476
initial concentration: NaN
type: Species
name: SLC17A3
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM pectintchol e
is: HMDB03402
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C2561H3555NO2542S CHARGE: 0
type: Species
has only substance units: false
constant: false
name: pectin-taurocholic acid complex

http://identifiers.org/biomodels.db/MODEL1310110033#_b9552d2c_a414_49ad_b770_c376fe436323
is encoded by: hsa:7378
constant: false
is: SBO:0000252
name: UPP1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q16831
type: Species
boundary condition: true

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR r1605
reactant: MODEL1310110033#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaR GTHP
reversible: true
is described by: ECO:0000134
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.11.1.12
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.15
type: Reaction
name: glutathione peroxidase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.9
modifier: MODEL1310110033#

metaR r1926
product: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction

metaM ala D e
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: SBO:0000247
constant: false
initial concentration: 1.0
name: D-alanine
is: HMDB01310
boundary condition: false
is: CHEBI:15570
initial amount: NaN
type: Species

metaM gua c
name: Guanine
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:16235
constant: false
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
boundary condition: false
is: SBO:0000247
is: C00242

metaM arachdcoa x
is: CHEBI:57368
is: HMDB06523
type: Species
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: arachidonoyl-CoA(4-)
constant: false

metaR r1602
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR ADPCOACROT
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_b6f3f492_73c0_4d20_9ad9_c247b8f800f4
is encoded by: hsa:5213
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has part: P08237
is: SBO:0000297
name: PFKM:PFKP

http://identifiers.org/biomodels.db/MODEL1310110033#_6a6c94fe_8a25_47c6_9af8_aad1a962c978
is: SBO:0000252
is: P47989
type: Species
is encoded by: hsa:7498
name: XDH
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaM ttdca c
boundary condition: false
initial amount: NaN
constant: false
name: myristate
is: CHEBI:30807
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: SBO:0000247
is: HMDB00806
type: Species
initial concentration: 1.0
has only substance units: false

metaM pmtcrn c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
is: CHEBI:17490
initial concentration: 1.0
has only substance units: false
name: L-palmitoylcarnitine
is: HMDB00222
constant: false
initial amount: NaN

metaR 2HCO3 NAt
modifier: MODEL1310110033#
product: MODEL1310110033#
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

metaR r0974
kinetic law: MODEL1310110033#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is: SBO:0000185
product: MODEL1310110033#
name: Active transport
fast: false

MODEL1310110033#
species: metaM ptrc e
species: metaM 1pipdn2c x
species: metaM amp c
species: metaM glx c
species: metaM nrpphr e
stoichiometry: 1.96
species: metaM octa e
species: metaM dha e
species: metaM HC02175 e
species: metaM fadh2 x
species: metaM glyald m
stoichiometry: 0.385872
species: metaM CE2424 m
species: metaM mi145p c
species: metaM udpacgal l
species: metaM bilglcur r
species: metaM txa2 c
species: metaM hom L e
species: metaM 2obut m
species: metaM idour l
species: metaM retinal c
species: metaM acgam1p c
species: metaM bilglcur e
species: metaM udpg c
species: metaM so4 e
species: metaM acrn r
species: metaM 3mop e
multipler: 2.77777777777778E-4
species: metaM gpail hs c
species: metaM pmtcrn c
species: metaM sgalside hs l
species: metaM ump n
species: metaM crvnc e
name: PIK3CB:PIK3R3
species: metaM ddcacoa x
species: metaM trdox c
species: metaM 5adtststerones e
species: metaM hs deg1 l
species: metaM sph1p c
species: metaM L2aadp6sa c
species: metaM itp n
species: metaM CE2705 n
species: metaM xyl D l
species: metaM dhcholestanate c
species: metaM pe hs c
species: metaM hexdiac r
species: metaM glac r
species: metaM tymsf e
species: metaM octa c
species: metaM leu L c
name: HEXA:HEXB
species: metaM gtp m
species: metaM HC02175 c
species: metaM apoC c
species: metaM btamp c
species: metaM idp c
stoichiometry: 20.0
species: metaM ha l
species: metaM utp n
species: metaM guln r
species: metaM thmpp m
species: metaM ac e
species: metaM pap c
species: metaM hs deg11 l
species: metaM pydxn c
species: metaM c12dccoa x
species: metaM gp1calpha hs c
species: metaM hom L c
species: metaM atp n
species: metaM 3mob m
species: metaM ksi deg13 l
species: metaM amp r
species: metaM dpcoa e
species: metaM ibcoa m
species: metaM acgam r
species: metaM malthx e
species: metaM glu L m
species: metaM akg x
species: metaM oaa m
species: metaM cdp e

metaR r1701
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaR ADSK
reversible: false
product: MODEL1310110033#
name: adenylyl-sulfate kinase
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
type: Reaction
modifier: MODEL1310110033#

metaM Rtotal l
boundary condition: false
is: CHEBI:52639
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
has only substance units: false
type: Species
is: SBO:0000247
name: R total
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_433dd8e5_7945_4e95_8c9d_5320e6530065
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: ACP1
type: Species
is encoded by: hsa:52
is: SBO:0000252
is: Q59EH3

metaR ITPtn
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110033#
name: ITP nuclear transport

metaR r1603
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false

metaM ala D c
type: Species
initial amount: NaN
initial concentration: 1.0
name: D-alanine
is: SBO:0000247
constant: false
is: HMDB01310
boundary condition: false
has only substance units: false
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110033#_90605c7d_01f0_4448_bb16_2f7b43d34872
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:57282
name: SLC4A10
is: B7Z1R0
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM nadh c
is: HMDB01487
initial amount: NaN
is: SBO:0000247
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
type: Species
constant: false
is: CHEBI:57945
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0

metaR r0973
name: Facilitated diffusion
reactant: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#

metaM 4pyrdx e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:30959
initial amount: NaN
name: 4-pyridoxate
notes: FORMULA: C8H9NO4 CHARGE: 0 INCHI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)/p-1 EHMN_ABBREVIATION: C00847
is: HMDB00017
constant: false
type: Species

metaM lpam m
initial amount: NaN
name: lipoamide
is: CHEBI:17460
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: SBO:0000247
is: HMDB00962
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_b0f02c94_2439_4d83_a0c8_eaaf8706e375
is encoded by: hsa:9060
constant: false
type: Species
is: O95340
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PAPSS2

http://identifiers.org/biomodels.db/MODEL1310110033#_3f33873b_9999_4e00_b2d5_645d0fc2cf46
is encoded by: hsa:5464
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: PPA1
initial concentration: NaN
is: Q15181
has only substance units: false
boundary condition: true

metaR r2366
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
reversible: true

metaM CE2432 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
constant: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: CHEBI:57795
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR r1600
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000

metaM betald c
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: HMDB01252
is: CHEBI:15710
initial amount: NaN
name: betaine aldehyde
is: SBO:0000247
boundary condition: false

metaR r0434
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110033#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_db4fe147_2b6c_45e5_a846_f461d364269f
boundary condition: true
type: Species
is encoded by: hsa:D29675
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: _D29675_1_c
is: SBO:0000252

metaR r2365
fast: false
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

metaM ahcys c
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: S-Adenosyl-L-homocysteine
is: CHEBI:16680
constant: false
is: HMDB00939
is: C00021
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6ea2936f_710b_4e74_8891_fa5af01148fc
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:29922
type: Species
name: NME7
is: SBO:0000252

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaM pcrn c
initial concentration: 1.0
type: Species
is: SBO:0000247
name: propionyl-carnitine
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/107738
is: HMDB00824
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaR CMPACNAtg
reversible: true
fast: false
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
modifier: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
reactant: MODEL1310110033#
name: CMP-Sia Golgi transport via CMP antiport
is described by: ECO:0000269

metaR OLEICFATPtc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

metaM sbcoa x
is: C14143
initial amount: NaN
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
name: suberylcoa
constant: false
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB04047
is: SBO:0000247

metaM pac c
name: phenylacetate
has only substance units: false
is: HMDB00209
type: Species
boundary condition: false
constant: false
is: CHEBI:18401
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR r2364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
fast: false
reversible: true

metaR HDCAtr
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110033#
name: fatty acid transport via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_42402cb0_293a_4918_9a69_6790416a3b64
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q6FGQ4
is: SBO:0000252
is encoded by: hsa:5538
initial concentration: NaN
name: PPT1

metaR r0970
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
name: Active transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:

metaM hLkynr c
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: CHEBI:17380
constant: false
name: 3-hydroxy-L-kynurenine
initial amount: NaN
is: HMDB11631
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_a9e000fa_40c7_4f45_9c09_742c1640f8d3
is: B7Z792
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4720
name: NDUFS2
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR GLUt6
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
name: Glutamate transport via Na, H symport and K antiport
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110033#
reversible: false
modifier: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185

metaM met L c
is: SBO:0000247
type: Species
is: HMDB00696
has only substance units: false
boundary condition: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
constant: false
initial concentration: 1.0
is: CHEBI:16643
initial amount: NaN
name: L-methionine

metaM tststerone c
type: Species
initial concentration: 1.0
has only substance units: false
name: testosterone
is: SBO:0000247
is: HMDB00234
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
boundary condition: false
is: CHEBI:17347
constant: false
initial amount: NaN

metaR TYRTA
reversible: true
fast: false
modifier: MODEL1310110033#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
name: tyrosine transaminase
is: SBO:0000176
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_b07f1b7e_3cd2_456e_81c7_cf6c9d45afd1
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:5279
boundary condition: true
constant: false
is: SBO:0000252
name: PIGC

metaM bilglcur r
initial concentration: 1.0
has only substance units: false
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN
boundary condition: false
is: CHEBI:57767

http://identifiers.org/biomodels.db/MODEL1310110033#_db3289b2_bf36_4503_b083_afea95a4d0c1
boundary condition: true
type: Species
is: SBO:0000252
is: Q92521
initial concentration: NaN
name: PIGB
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:9488

metaR S6TASE24ly
type: Reaction
reactant: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR r2363
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true

metaR PALFATPtc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_e20d0c84_65a0_4789_8932_ebd6a868ee03
constant: false
boundary condition: true
is: Q16773
is encoded by: hsa:883
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: CCBL1
has only substance units: false

metaR CSEPASEly
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
is described by: ECO:0000000
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reversible: false
product: MODEL1310110033#

metaM Asn X Ser Thr l
is: HMDB00051
has only substance units: false
is: C01342
constant: false
is: CHEBI:28938
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
name: protein-linked asparagine residue (N-glycosylation site)
boundary condition: false

metaM g3p c
boundary condition: false
is: CHEBI:58027
name: Glyceraldehyde 3-phosphate
is: http://identifiers.org/pubchem.compound/3930
initial concentration: 1.0
type: Species
is: HMDB01112
is: C00661
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: SBO:0000247
constant: false
has only substance units: false

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_231ac40a_699a_445c_9ba5_42c7484d9449
name: SLC8A3
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6547

metaM gthrd m
name: glutathionate(1-)
is: SBO:0000247
is: CHEBI:57925
boundary condition: false
initial concentration: 1.0
is: HMDB00125
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
has only substance units: false
constant: false

metaR FAS100COA
modifier: MODEL1310110033#
reversible: false
name: fatty acyl-CoA synthase (n-C10:0CoA)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176

metaR SGALSIDEtl
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: sgalside hs intracellular transport
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_5862422d_709e_4b84_bf98_ab3432027ad6
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2222
boundary condition: true
name: FDFT1
is: P37268
has only substance units: false
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_ab92f58e_d7ed_435d_a88c_598da1b19761
is: P55084
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3032
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: HADHB
boundary condition: true

metaR ORNt3m
product: MODEL1310110033#
reversible: true
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
name: ornithine mitochondrial transport via proton antiport
modifier: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269

metaM pmtcrn m
is: HMDB00222
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: L-palmitoylcarnitine
has only substance units: false
constant: false
is: CHEBI:17490
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

http://identifiers.org/biomodels.db/MODEL1310110033#_b19a8f54_017f_4ca9_af14_5b0545dfb337
is encoded by: hsa:5277
name: PIGA
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P37287
boundary condition: true
is: SBO:0000252

metaM tststerone e
is: CHEBI:17347
constant: false
type: Species
name: testosterone
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: HMDB00234
is: SBO:0000247

metaR r0661
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
reversible: false
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_51a11306_c34f_4cc1_b502_b9dd69f20ff9
is: P07451
constant: false
boundary condition: true
is encoded by: hsa:761
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: CA3

metaM 4nphsf e
type: Species
name: 4-Nitrophenyl sulfate
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB06492
constant: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: SBO:0000247
is: CHEBI:35422
boundary condition: false

metaM CE4872 c
constant: false
initial concentration: 1.0
is: CHEBI:15748
is: SBO:0000247
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00127
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al

http://identifiers.org/biomodels.db/MODEL1310110033#_5ca49188_b95a_4ef4_a26e_a65a58a2a6a7
constant: false
is: SBO:0000252
type: Species
name: SLC35C1
initial concentration: NaN
boundary condition: true
is: B3KQH0
is encoded by: hsa:55343
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_58a6458b_2b06_4748_a5e1_315ce77ee955
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:56623
type: Species
has only substance units: false
name: INPP5E
is: Q9NRR6
constant: false
boundary condition: true

metaM ksi deg26 l
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58343
boundary condition: false
initial amount: NaN
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: HMDB00061
name: keratan sulfate I, degradation product 26
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_6905d9fc_6388_43d5_9994_371dc0c6e040
initial concentration: NaN
is: Q9Y633
is encoded by: hsa:5136
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: PDE1A
is: SBO:0000252
constant: false

metaM HC00319 m
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:30794
boundary condition: false
name: Malonate
constant: false
initial amount: NaN
has only substance units: false

metaR 5OXPROt
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-oxoprolinate
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_38cdde01_a00f_4d78_8166_857614645ff1
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: PIGF
is: Q6IB04
is encoded by: hsa:5281

metaM Rtotal e
boundary condition: false
is: HMDB00244
type: Species
is: CHEBI:3554
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: R total
notes: FORMULA: CO2FULLR CHARGE: -1
is: C00255
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_cdc24f81_17f5_4731_beb2_081fcb764c83
constant: false
type: Species
boundary condition: true
name: NT5C
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:30833
has only substance units: false
is: Q8TCD5

metaR NH4tp
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: ammonia peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110033#
type: Reaction

metaR CYTK13n
name: cytidylate kinase (dCMP,dATP),nuclear
kinetic law: MODEL1310110033#
is described by: ECO:0000269
modifier: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110033#
type: Reaction
reversible: true

metaR r0660
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110033#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_582afec8_43c7_4a3b_947b_3c38992bbc03
initial amount: NaN
is: SBO:0000252
is: Q6IBB5
constant: false
initial concentration: NaN
type: Species
name: NDUFA1
is encoded by: hsa:4694
has only substance units: false
boundary condition: true

metaR r2369
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110033#
reversible: true
type: Reaction

metaR NDPK10
name: nucleoside-diphosphate kinase (ATP:dIDP)
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110033#
type: Reaction
fast: false
is described by: ECO:0000134
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_ae9fdb85_8ce2_41c3_990a_38305d984dd4
initial amount: NaN
name: PRDX2
is: P32119
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:7001
boundary condition: true
constant: false
is: SBO:0000252

metaM malthp e
initial concentration: 1.0
has only substance units: false
name: maltoheptaose
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: C01936
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837

metaM 10fthf m
name: 10-formyltetrahydrofolate(2-)
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00972
is: SBO:0000247
has only substance units: false
is: CHEBI:57454
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_dfb5595f_59c2_4c09_a3bf_1301964004fd
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: P11310
is encoded by: hsa:34
has only substance units: false
name: ACADM
constant: false
is: SBO:0000252

metaM 34dhoxmand m
is: SBO:0000247
initial amount: NaN
is: CHEBI:27637
name: 3,4-Dihydroxymandelate
has only substance units: false
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB01866
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580

metaR ME2
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.40
fast: false
type: Reaction
product: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: malic enzyme (NADP)

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaR SGALSIDEtg
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110033#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
type: Reaction
name: sgalside hs intracellular transport
reactant: MODEL1310110033#

metaM g6p c
is: CHEBI:61548
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
boundary condition: false
is: C00092
has only substance units: false
is: SBO:0000247
is: HMDB01401
initial concentration: 1.0
name: D-Glucose 6-phosphate
initial amount: NaN
type: Species

metaR r0437
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110033#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110033#_3299990a_6349_4543_adc4_ded2f50c20bd
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AI631997
type: Species
name: _AI631997_1_m
is: SBO:0000252

metaR r2368
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

metaM Rtotal c
name: R total
initial concentration: 1.0
is: HMDB01448
has only substance units: false
type: Species
is: CHEBI:16189
initial amount: NaN
boundary condition: false
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
is: SBO:0000247

metaM hs deg19 l
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB03178
type: Species
constant: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: C00032
initial concentration: 1.0
name: heparan sulfate, degradation product 19
is: CHEBI:17627

metaR MI14P4P
name: inositol-1,4-bisphosphate 4-phosphatase
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

metaR B3GNT51g
reactant: MODEL1310110033#
is described by: ECO:0000304
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
modifier: MODEL1310110033#
product: MODEL1310110033#

metaM datp c
name: dATP
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species
is: SBO:0000247
constant: false
is: HMDB01532
initial amount: NaN
is: C00131
is: CHEBI:61404
has only substance units: false

metaR r2367
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110033#
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110033#
is described by: ECO:0000000

metaR CYSGLTH
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
name: Glutathione:cystine oxidoreductase
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
type: Reaction

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR LTA4H
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000176
type: Reaction
product: MODEL1310110033#
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.3.2.6
modifier: MODEL1310110033#
name: Leukotriene A-4 hydrolase

metaR CHOLESTle
name: hydrolysis of cholesterol ester by cholesterol esterase
type: Reaction
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.1.13
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110033#
is described by: ECO:0000134
fast: false
product: MODEL1310110033#
reversible: false
is: SBO:0000176

metaR ADSS
is described by: ECO:0000134
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
name: adenylosuccinate synthase
is: SBO:0000176
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
kinetic law: MODEL1310110033#
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.4

http://identifiers.org/biomodels.db/MODEL1310110033#_6ea03ed9_562d_47cf_aa14_6cc3e5214f55
is: SBO:0000252
is: Q02318
type: Species
has only substance units: false
name: CYP27A1
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:1593

metaM taur e
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
has only substance units: false
constant: false
is: CHEBI:3544
initial amount: NaN
is: HMDB00251
is: SBO:0000247
type: Species
is: C00245
boundary condition: false
initial concentration: 1.0

metaR NH4tn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
name: ammonia nuclear transport
is: SBO:0000185
product: MODEL1310110033#
fast: false

metaM Ser Gly Ala X Gly l
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: SBO:0000247
is: HMDB02183
type: Species
is: CHEBI:36005
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_47f03c73_bb94_4576_b2ec_03270f9c7159
initial concentration: NaN
is: SBO:0000252
is: P04179
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: SOD2
is encoded by: hsa:6648

http://identifiers.org/biomodels.db/MODEL1310110033#_c1b83988_b898_42e4_bae9_fb82b304de71
boundary condition: true
is: SBO:0000252
constant: false
name: _AA526438_1_m
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AA526438

http://identifiers.org/biomodels.db/MODEL1310110033#_36e31fb2_6a75_4f25_ac09_602f7358454d
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: G5E960
is encoded by: hsa:5331
constant: false
boundary condition: true
initial amount: NaN
name: PLCB3
type: Species

metaM datp n
initial concentration: 1.0
type: Species
is: HMDB01532
is: SBO:0000247
is: C00131
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
name: dATP
is: CHEBI:61404

metaR MAN1PT2
is version of: http://identifiers.org/ec-code/2.7.7.13
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
name: mannose-1-phosphate guanylyltransferase (GDP)
modifier: MODEL1310110033#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_1b0d9456_3662_4b73_b79c_d9055a4667be
boundary condition: true
is encoded by: hsa:6817
is: SBO:0000252
constant: false
name: SULT1A1
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN

metaR UMPK4n
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110033#
name: UMP kinase (GTP),nuclear
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000176
type: Reaction
reversible: true

metaM phe L c
is: HMDB00159
is: CHEBI:17295
name: L-phenylalanine
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_982955d3_89bf_4c1b_a8a6_6ae815b18e61
has part: P07195
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3945
boundary condition: true
is encoded by: hsa:3939
name: LDHA:LDHB
is: SBO:0000297
has part: P00338
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_b1b50378_2b1a_4bd0_9091_2240b7f6c68a
has only substance units: false
boundary condition: true
name: MYO5B
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:4645
is: Q9H6Y6
initial concentration: NaN
initial amount: NaN

metaM cs a l
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:36005
constant: false
is: HMDB02183
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110033#_5102f4e7_3ff8_46d7_8eee_2d99947d6c67
has only substance units: false
name: NEU1
is: SBO:0000252
initial amount: NaN
is: Q99519
type: Species
boundary condition: true
constant: false
is encoded by: hsa:4758
initial concentration: NaN

metaM 3oddcoa m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:27868
name: 3-Oxododecanoyl-CoA
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_78d75b33_e833_4d50_b6ed_b2ebee3e54cd
constant: false
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:221
is: P43353
initial concentration: NaN
name: ALDH3B1
initial amount: NaN
is: SBO:0000252

metaR PGK
is: SBO:0000176
reversible: true
name: phosphoglycerate kinase
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/2.7.2.3

http://identifiers.org/biomodels.db/MODEL1310110033#_afc706b8_1b93_4a14_a741_2ce25a3553cf
type: Species
has only substance units: false
is: P08319
is: SBO:0000252
is encoded by: hsa:127
name: ADH4
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaR FAS120COA
type: Reaction
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C12:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110033#_ef37e057_e7b2_480b_b9bb_dcf7862d3f90
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: _H17063_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:H17063

metaM datp m
initial concentration: 1.0
name: dATP
initial amount: NaN
constant: false
is: HMDB01532
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:61404
has only substance units: false
is: C00131
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131

metaM hxan c
boundary condition: false
has only substance units: false
is: CHEBI:17368
is: C00262
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
name: Hypoxanthine
initial amount: NaN
initial concentration: 1.0
is: HMDB00157
type: Species
is: SBO:0000247

metaM pmtcrn r
is: SBO:0000247
is: HMDB00222
is: CHEBI:17490
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
name: L-palmitoylcarnitine

metaR LPS2
product: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.1.34
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
name: lipase
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
reversible: false
type: Reaction
reactant: MODEL1310110033#

metaR RE1519M
reversible: true
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: RE1519

metaM phe L e
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false
is: CHEBI:17295
type: Species
name: L-phenylalanine
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00159

metaR PI45PLC
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
kinetic law: MODEL1310110033#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.11
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_6af6191d_d987_4b8b_9e36_98bf86246925
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: C9JZ62
initial concentration: NaN
boundary condition: true
is encoded by: hsa:641649
constant: false
name: TMEM91

http://identifiers.org/biomodels.db/MODEL1310110033#_e7aa285d_b5d4_4e21_922b_cfddaf6d4efa
boundary condition: true
constant: false
is encoded by: hsa:AV717590
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: _AV717590_1_m
initial concentration: NaN

metaR r0879
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
type: Reaction
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
kinetic law: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000

metaR GP1CALPHAtg
type: Reaction
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000000
name: gp1calpha hs intracellular transport
product: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185
reactant: MODEL1310110033#

metaR r0641
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.4
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
type: Reaction
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
reversible: true
product: MODEL1310110033#

metaM acgal1p c
is: CHEBI:55404
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
is: HMDB06480
name: N-Acetyl-D-galactosamine 1-phosphate
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_a512823f_72d2_4d45_8f4b_4a9fa7d0fe0c
is encoded by: hsa:226
name: ALDOA
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR PGI
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
modifier: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.9
name: glucose-6-phosphate isomerase
fast: false
reactant: MODEL1310110033#
is: SBO:0000176

metaM xylt e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
initial amount: NaN
type: Species
name: xylitol
has only substance units: false
is: SBO:0000247
is: CHEBI:17151
constant: false
is: HMDB02917

http://identifiers.org/biomodels.db/MODEL1310110033#_65be4b67_99ac_4dff_a61a_8552ba9f805a
name: ACO1
boundary condition: true
is: P21399
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:48
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR r2371
type: Reaction
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110033#

metaR r0642
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110033#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
fast: false
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000176
reactant: MODEL1310110033#

metaM HC02210 e
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:34939
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false
name: prostaglandin-d3

http://identifiers.org/biomodels.db/MODEL1310110033#_33e6bd49_c8f1_4811_95b1_74094ebcb20b
name: ALDH1B1
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:219
type: Species
is: P30837

metaM fad m
name: Flavin adenine dinucleotide oxidized
is: C00016
initial amount: NaN
is: HMDB01248
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM hxan e
is: SBO:0000247
initial concentration: 1.0
name: hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00157
is: CHEBI:17368

http://identifiers.org/biomodels.db/MODEL1310110033#_f2141a15_5926_4bbd_be14_44157398186e
constant: false
boundary condition: true
is encoded by: hsa:518
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: ATP5G3

metaR r2372
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110033#
type: Reaction

metaM 44mctr r
boundary condition: false
type: Species
is: CHEBI:17813
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: HMDB01023
initial amount: NaN
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_b64ecede_00e3_41cc_8802_694d10f05b1e
initial amount: NaN
has only substance units: false
is encoded by: hsa:22305
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _22305_1_c
type: Species
constant: false

metaM pi e
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009
is: HMDB00973
is: CHEBI:43474

metaM HC02210 c
is: SBO:0000247
type: Species
name: prostaglandin-d3
has only substance units: false
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:34939

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM 3mob c
type: Species
is: CHEBI:11851
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: HMDB00019
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: 3-methyl-2-oxobutanoate
has only substance units: false

metaR r0644
product: MODEL1310110033#
type: Reaction
fast: false
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaR r2373
product: MODEL1310110033#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
fast: false

metaR r0539
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.34
reactant: MODEL1310110033#
modifier: MODEL1310110033#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_3a64a754_1978_42eb_bd1a_4733066b2824
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:R51273
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _R51273_1_c

metaR ASPDt6
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: D-aspartate transport via Na, H symport and K antiport
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
is described by: ECO:0000269
fast: false
reversible: false
is: SBO:0000185
type: Reaction

metaR B3GALT42g
reversible: false
fast: false
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.1.62
name: Beta-1,3-galactosyltransferase 4

metaR SBTR
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
name: D-sorbitol reductase
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_0f1dc2dd_3a0d_416b_9c7b_b58d6c410601
name: FLAD1
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:80308

metaM pi g
is: HMDB00973
name: hydrogenphosphate
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:43474
has only substance units: false
constant: false
initial amount: NaN

metaR r2374
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000185

metaR SERGLNexR
reversible: true
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
fast: false
type: Reaction
name: L-Serine/Glutamine reversible exchange

metaR r1492
name: Utilized transport
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_f9d017b6_720c_4298_9467_c597edf6ff84
initial concentration: NaN
name: OGDH
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4967
constant: false
is: Q02218
type: Species
has only substance units: false
initial amount: NaN

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM 3mob e
initial amount: NaN
has only substance units: false
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB00019
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
constant: false
is: CHEBI:11851

http://identifiers.org/biomodels.db/MODEL1310110033#_151dc1db_2170_477c_b386_2a1f3c31ffc6
name: GCH1
is: Q8IZH9
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:2643

http://identifiers.org/biomodels.db/MODEL1310110033#_258a9a76_9f06_471a_9d8e_dfbd9759926d
initial concentration: NaN
is: E9PHN8
type: Species
initial amount: NaN
constant: false
name: HEPH
is encoded by: hsa:9843
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR DTMPK
is version of: http://identifiers.org/ec-code/2.7.4.9
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110033#
name: dTMP kinase

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_035b4662_2fdb_4c2a_be6d_918eb68b36bf
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:522
constant: false
has only substance units: false
name: ATP5J
boundary condition: true
initial concentration: NaN

metaM gncore2 g
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C30H50N3O20X CHARGE: 0
name: GlcNAc-alpha-1,4-Core 2
is: CHEBI:15876
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_083365df_f8dd_4942_82ca_b765d269ab93
name: CHKB
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q9Y259
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:1120

metaR r0647
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
kinetic law: MODEL1310110033#
type: Reaction
fast: false
name: Spontaneous reaction
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_9e677526_1fcc_4166_89b2_d6909bbe7b65
is: SBO:0000252
type: Species
boundary condition: true
is: Q96RQ3
constant: false
is encoded by: hsa:56922
initial amount: NaN
name: MCCC1
initial concentration: NaN
has only substance units: false

metaM pydx c
is: C00250
is: HMDB01545
type: Species
name: Pyridoxal
initial concentration: 1.0
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
is: CHEBI:17310
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR NAIt
kinetic law: MODEL1310110033#
is described by: ECO:0000269
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
fast: false
modifier: MODEL1310110033#
type: Reaction
name: Na+ / iodide cotransport

metaM pmtcrn x
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: SBO:0000247
name: L-palmitoylcarnitine
is: HMDB00222
is: CHEBI:17490

metaR SERDGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110033#
is: SBO:0000185
type: Reaction
name: D-Serine/Glutamine reversible exchange
fast: false
is described by: ECO:0000304
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR NDPK10n
reversible: true
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
product: MODEL1310110033#
type: Reaction

metaR r1051
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
is: SBO:0000185
type: Reaction
name: Vesicular transport
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
kinetic law: MODEL1310110033#

metaM adpcoa x
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: SBO:0000247
name: adipoylcoa
initial concentration: 1.0
is: C14143
boundary condition: false
type: Species
is: HMDB04047

metaM galside hs c
constant: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
name: D-galactosyl-N-acylsphingosine
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:12947
type: Species

metaR r1910
fast: false
reversible: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaR r0321
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.2
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16

http://identifiers.org/biomodels.db/MODEL1310110033#_a404e8a2_eaff_4859_91ab_22293fa8c7b9
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4697
constant: false
is: O00483
name: NDUFA4

metaM xylt c
is: SBO:0000247
initial amount: NaN
is: CHEBI:17151
is: HMDB02917
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
name: xylitol
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_efb429f4_afdc_4df9_8862_4294adcdc1aa
initial amount: NaN
is encoded by: hsa:30
has only substance units: false
name: ACAA1
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q96CA6

http://identifiers.org/biomodels.db/MODEL1310110033#_2b7a0691_ad67_4f0f_b341_079a4b3dbc8b
initial amount: NaN
boundary condition: true
name: HAS2
is: SBO:0000252
has only substance units: false
type: Species
is: Q92819
is encoded by: hsa:3037
initial concentration: NaN
constant: false

metaR GLYGLYPEPT1tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycyl-glycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR r0870
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.72
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.4
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110033#
name: Facilitated diffusion
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.4.13

http://identifiers.org/biomodels.db/MODEL1310110033#_0e868e07_98b6_4428_b713_da3a56f421bb
is: Q6PCB7
boundary condition: true
has only substance units: false
name: SLC27A1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:376497

metaM pi c
has only substance units: false
constant: false
is: HMDB00973
name: hydrogenphosphate
boundary condition: false
is: C00009
is: CHEBI:43474
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2
initial amount: NaN
type: Species

metaR r1050
is: SBO:0000185
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
fast: false
is described by: ECO:0000000
name: Vesicular transport

metaM mi1345p c
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
boundary condition: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: CHEBI:57895
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01059

metaM retinol e
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:50211
initial amount: NaN
boundary condition: false
is: HMDB00305
type: Species
has only substance units: false
name: retinol

http://identifiers.org/biomodels.db/MODEL1310110033#_31bd7b78_398d_4433_972c_90523857bfec
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:AU149534
initial concentration: NaN
name: _AU149534_1_m

metaR r2443
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000185
fast: false
reversible: false
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_0276babb_253c_47ca_be08_51174633e6e8
initial amount: NaN
name: CA12
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:771
is: O43570
boundary condition: true
constant: false
has only substance units: false

metaR GALASE5ly
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
product: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
is: SBO:0000176

metaM phe L m
type: Species
is: SBO:0000247
name: L-phenylalanine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
constant: false
is: HMDB00159
has only substance units: false
is: CHEBI:17295

metaR SO4t4 2
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
name: sulfate transport via sodium symport
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_30350885_a6c1_48f8_a83a_4e01cbd2563b
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2348
name: FOLR1

metaR DCMPDA
reversible: true
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.12
name: dCMP deaminase
product: MODEL1310110033#
type: Reaction
fast: false
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_f2bf7030_6ec8_4f32_98a2_da13895b8b02
is: O00754
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: MAN2B1
initial amount: NaN
is encoded by: hsa:4125
boundary condition: true

metaR DURAD
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
name: dihydrouracil dehydrogenase (NADP)
reactant: MODEL1310110033#
reversible: true
type: Reaction
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.1.2
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000269
fast: false

metaR r0871
is: SBO:0000185
reversible: true
fast: false
name: Diffusion
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
is described by: ECO:0000000

metaM cys L c
name: L-cysteine
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17561
initial concentration: 1.0
is: HMDB00574
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_07ea3975_912d_479e_b1e9_0dc0dc0975d1
is encoded by: hsa:10637
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: LEFTY1
is: O75610
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_65209029_1c31_4c1f_b5be_98e39c9e1aa8
is: P30566
initial amount: NaN
is: SBO:0000252
name: ADSL
constant: false
initial concentration: NaN
is encoded by: hsa:158
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_96d72b82_8ab7_4870_a6cc_f4d020a5bcf3
type: Species
has only substance units: false
is encoded by: hsa:1606
is: P23743
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: DGKA
initial amount: NaN

metaR PRODt2r
modifier: MODEL1310110033#
is described by: ECO:0000304
product: MODEL1310110033#
is: SBO:0000185
name: D-proline reversible transport via proton symport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_8376e622_38de_4180_b2e2_e2cf538f155d
has only substance units: false
name: GGT2
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:728441

http://identifiers.org/biomodels.db/MODEL1310110033#_1f4e1d77_a5b7_43f5_948d_85cff807a239
constant: false
type: Species
initial concentration: NaN
name: CPT1B
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1375
has only substance units: false
is: E9PCP2
boundary condition: true

metaM retinol c
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:50211
is: HMDB00305
has only substance units: false
name: retinol
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_23e0a026_aee4_41cb_969c_01c60c1102e1
initial amount: NaN
is: Q308M7
initial concentration: NaN
constant: false
boundary condition: true
name: ENPP3
is encoded by: hsa:5169
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_eef511ce_85a1_43a2_86f6_af3c4d54146c
constant: false
has only substance units: false
name: _AI935189_1_m
initial concentration: NaN
is encoded by: hsa:AI935189
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR GP1CALPHAte
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
is: SBO:0000185
fast: false
name: gp1calpha hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

metaR r0531
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
is version of: http://identifiers.org/ec-code/1.1.1.34
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true

metaM HC02121 c
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
initial amount: NaN
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758
has only substance units: false

metaM cys L e
has only substance units: false
name: L-cysteine
is: SBO:0000247
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
type: Species
is: CHEBI:17561
boundary condition: false
is: HMDB00574
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_75adf614_35b2_4101_94c7_eaf0c7b80ff3
initial amount: NaN
constant: false
boundary condition: true
name: RHBG
is encoded by: hsa:57127
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9H310

metaM fad x
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:16238
constant: false
is: HMDB01248
initial amount: NaN
has only substance units: false

metaM nad c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: Nicotinamide adenine dinucleotide
boundary condition: false
is: CHEBI:57540
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
is: C00003
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_e9f45fd4_1a95_4850_81c6_93a20143c9d3
type: Species
initial amount: NaN
is encoded by: hsa:6241
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: RRM2
boundary condition: true
is: P31350

metaR NACHEX24ly
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
modifier: MODEL1310110033#

metaM akg x
is: CHEBI:16810
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
is: HMDB00208
name: 2-oxoglutarate(2-)

metaR RDH3a
is version of: http://identifiers.org/ec-code/1.1.1.105
is version of: http://identifiers.org/ec-code/1.1.1.300
name: retinol dehydrogenase (11-cis,NADPH)
reactant: MODEL1310110033#
fast: false
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is: SBO:0000176
modifier: MODEL1310110033#
product: MODEL1310110033#

metaM clpn hs c
initial concentration: 1.0
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
name: cardiolipin
type: Species
has only substance units: false
is: CHEBI:28494
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaM galside hs g
is: SBO:0000247
constant: false
type: Species
name: D-galactosyl-N-acylsphingosine
is: CHEBI:12947
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_1ffc57fa_9c6b_40c3_99be_d9bf51003dd1
is encoded by: hsa:11238
type: Species
name: CA5B
is: Q9Y2D0
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR NRPPHRSULT
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
is: SBO:0000176
name: Norepinephrine Sulfotransferase
kinetic law: MODEL1310110033#
type: Reaction
reversible: false

metaR D3AIBTm
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM

metaM 3mob m
initial concentration: 1.0
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:11851
initial amount: NaN
constant: false
name: 3-methyl-2-oxobutanoate
boundary condition: false

metaR RE3565C
type: Reaction
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
fast: false
name: RE3565

metaR r1618
reversible: true
modifier: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#

metaR Htx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110033#
is: SBO:0000185
name: H transporter, peroxisome
type: Reaction
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false

metaR DOLPMT3 Uer
kinetic law: MODEL1310110033#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.260
reactant: MODEL1310110033#
is: SBO:0000176
fast: false
product: MODEL1310110033#
reversible: false
modifier: MODEL1310110033#

metaR ME1m
type: Reaction
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
modifier: MODEL1310110033#
reversible: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
name: malic enzyme (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.38

metaM fe2 c
is: HMDB00692
has only substance units: false
is: C00023
is: SBO:0000247
is: CHEBI:29033
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: Fe2+
type: Species
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023

metaR ORNt4m
is: SBO:0000185
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
modifier: MODEL1310110033#
name: ornithine mitochondrial transport exchange with citruline
type: Reaction
reversible: true

metaM hyptaur c
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00965
constant: false
name: Hypotaurine
is: CHEBI:16668
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519

http://identifiers.org/biomodels.db/MODEL1310110033#_71241738_ea89_4733_b85d_6b34aa57135d
initial concentration: NaN
is: B7Z6S1
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:2629
name: GBA
has only substance units: false
initial amount: NaN
type: Species

metaM C05957 r
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB02710
type: Species
is: CHEBI:27485
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
name: Prostaglandin J2
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_dc4d0313_d02b_464e_bb98_12176796dbd5
name: HADHB
has only substance units: false
is encoded by: hsa:3032
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P55084

metaR r1619
product: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_63196bac_5a00_45fe_8e45_ed47e6ecc75a
boundary condition: true
has part: Q92569
is encoded by: hsa:5293
type: Species
name: PIK3CD:PIK3R3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8503
has part: A7E2E0
has only substance units: false
constant: false
is: SBO:0000297

metaR r0989
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
fast: false
is: SBO:0000185
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_800dd175_58fe_44c5_b65d_4bbe69fac263
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: ACOX1
is: SBO:0000252
is encoded by: hsa:51
is: B4DK61

metaR MANtly
is: SBO:0000185
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: mannose efflux from lysosome
type: Reaction
kinetic law: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
is described by: ECO:0000000

metaR GULNDer
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110033#
name: gulonate dehydrogenase, endoplasmic reticulum
kinetic law: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
reversible: true

metaR PPDOy
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.2

http://identifiers.org/biomodels.db/MODEL1310110033#_688252a9_3310_4591_921e_ad3130be62f9
is: SBO:0000252
constant: false
boundary condition: true
name: DGKD
initial concentration: NaN
is encoded by: hsa:8527
is: Q16760
type: Species
initial amount: NaN
has only substance units: false

metaM acetone m
boundary condition: false
constant: false
is: CHEBI:15347
initial concentration: 1.0
initial amount: NaN
is: HMDB01659
has only substance units: false
name: acetone
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: SBO:0000247
type: Species

metaR RE2659R
name: RE2659
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110033#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#
reversible: true

metaM fad c
is: C00016
is: HMDB01248
initial amount: NaN
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Flavin adenine dinucleotide oxidized
is: CHEBI:16238
type: Species

metaM hyptaur e
name: Hypotaurine
is: CHEBI:16668
is: HMDB00965
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR PPDOx
modifier: MODEL1310110033#
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_afa4577a_8dd0_4834_a7d9_c281d5b6b6b3
name: NDUFS3
is encoded by: hsa:4722
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: O75489
constant: false
has only substance units: false

metaR FUT34g
reactant: MODEL1310110033#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.65
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2525.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110033#
name: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1

metaM L2aadp6sa c
boundary condition: false
is: CHEBI:17917
type: Species
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: L-allysine
constant: false
is: HMDB01263

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR r1918
product: MODEL1310110033#
reactant: MODEL1310110033#
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false

metaM CE5854 e
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial amount: NaN
name: gama-CEHC-glucuronide
type: Species
is: HMDB02710
is: CHEBI:27485
is: SBO:0000247

metaR GPIDAer
modifier: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
reversible: false
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum

metaM glutcoa m
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
name: glutaryl-CoA(5-)
is: HMDB01339
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: CHEBI:57378
boundary condition: false

metaR r0317
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000000
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
type: Reaction
modifier: MODEL1310110033#
reversible: true

metaR HSAT4ly
is: SBO:0000185
product: MODEL1310110033#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR r1614
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_1b68aa3c_5f84_44aa_acfe_b57abdc213c9
is encoded by: hsa:6507
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: Q7Z5T0
constant: false
initial amount: NaN
has only substance units: false
name: SLC1A3

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR RE1807M
reversible: true
modifier: MODEL1310110033#
type: Reaction
is: SBO:0000176
name: RE1807
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaR ENGASE3ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
reversible: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_a549016d_7895_47b0_81ea_d9f4475c8a59
boundary condition: true
is encoded by: hsa:117247
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q8TF71
name: SLC16A10
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_7c55b6ad_3115_4d74_ad40_e677c3cd4524
is: SBO:0000252
has only substance units: false
name: SLC4A5
type: Species
constant: false
is encoded by: hsa:57835
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_6706c974_73c4_43a1_abd7_ab777d1e89dc
has only substance units: false
boundary condition: true
is: SBO:0000252
name: OXSM
is: Q9NWU1
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:54995
initial concentration: NaN

metaR 2OXOADOXm
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/2.3.1.61
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.2.4.2
reversible: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110033#_a0a3b3d8_f14e_440e_9a8e_84a0d048cfc2
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: _AI971036_1_c
is: SBO:0000252
is encoded by: hsa:AI971036
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_44e016e9_e94c_4e46_845f_ee537c813453
is: Q9BW60
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ELOVL1
is encoded by: hsa:64834
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_36a80222_069d_4c27_a90a_fc6112f6c5c0
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
name: PLA2G5
is: P39877
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5322

metaM dutp m
name: dUTP
boundary condition: false
type: Species
is: CHEBI:17625
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
is: SBO:0000247
is: HMDB01191
initial concentration: 1.0

metaR r1615
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaM dump n
type: Species
is: HMDB01409
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: CHEBI:246422
boundary condition: false
name: dUMP(2-)
initial concentration: 1.0

metaM pe hs m
initial amount: NaN
type: Species
name: phosphatidylethanolamine
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: CHEBI:16038
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

metaR r0311
fast: false
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
modifier: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_03bfdfcc_9cc9_4e95_9c70_6804a6bfd34c
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: P36542
is encoded by: hsa:509
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ATP5C1

metaM dutp n
name: dUTP
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
is: CHEBI:17625
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB01191

metaM CE2431 m
is: CHEBI:57795
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: cis-deca-4-enoyl-CoA

metaM fe2 e
is: C00023
is: HMDB00692
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:29033
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
name: Fe2+

metaR r1616
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_05096c33_c2bb_423f_a40b_d28897de67c8
type: Species
initial amount: NaN
is: P54802
name: NAGLU
has only substance units: false
is encoded by: hsa:4669
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_c92941cd_de80_4628_9523_e5277e20e93e
initial concentration: NaN
initial amount: NaN
name: AOX1
is: Q06278
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:316
boundary condition: true
type: Species

metaR Htr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000185
name: H transporter, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110033#_6d0adedb_8c1c_4b59_8b6a_0b6621328abc
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: PLA2G2D
is: SBO:0000252
has only substance units: false
is: Q9UNK4
is encoded by: hsa:26279

http://identifiers.org/biomodels.db/MODEL1310110033#_669304f4_d08a_4227_adf0_63cf956eda65
type: Species
initial concentration: NaN
name: ALDH3B1
is: SBO:0000252
is: P43353
is encoded by: hsa:221
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true

metaR ABUTt2r
kinetic law: MODEL1310110033#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
fast: false
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000304
product: MODEL1310110033#
name: 4-aminobutyrate reversible transport in via proton symport

http://identifiers.org/biomodels.db/MODEL1310110033#_4de6c643_ebfa_46e0_9db3_01f3f435ded6
is encoded by: hsa:33
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P28330
constant: false
name: ACADL
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_08543f76_6e9b_4900_8115_f1d8fe561ec1
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4701
is: SBO:0000252
type: Species
is: Q6FG42
name: NDUFA7
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6b679ad0_05c7_4192_b52e_f933b2701a65
initial concentration: NaN
name: SUCLG2
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:8801
is: Q96I99
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM cholcoaone x
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:58507
has only substance units: false
is: HMDB06891
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_fc1701b5_9c02_4322_adf4_495ffab0fc35
is: P31350
is encoded by: hsa:6241
type: Species
initial concentration: NaN
constant: false
name: RRM2
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM lpchol hs c
is: CHEBI:60479
initial concentration: 1.0
name: lysophosphatidylcholine
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
has only substance units: false
boundary condition: false

metaR r1617
is: SBO:0000185
reactant: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_aff15ff6_5f48_475b_9a32_5c4fd6e9ed5b
initial amount: NaN
initial concentration: NaN
is: Q9BV10
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: ALG12
boundary condition: true
is encoded by: hsa:79087

metaR BALAtmr
name: Beta-alanine reversible mitochondrial transport (diffusion)
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
is described by: ECO:0000000
kinetic law: MODEL1310110033#

metaR TRIODTHYt2
name: T3 transport via facilitated diffusion
is: SBO:0000185
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction

metaR PEt
fast: false
product: MODEL1310110033#
name: phosphatidylethanolamine transport
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR ILEt5m
is: SBO:0000185
product: MODEL1310110033#
reactant: MODEL1310110033#
name: Isoleucine mitochondrial transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM

metaM chlstol r
is: HMDB06842
initial concentration: 1.0
is: CHEBI:16290
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_50f01dab_447f_4920_a8ca_9d19f959b3db
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:522
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: Q6NZ59
name: ATP5J

http://identifiers.org/biomodels.db/MODEL1310110033#_6eef2aa8_422e_4f9a_b71d_f4aeb8b71d58
initial concentration: NaN
is encoded by: hsa:284098
is: SBO:0000252
is: Q7Z7B1
name: PIGW
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaR HOXG
is version of: http://identifiers.org/ec-code/1.14.99.3
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
is described by: ECO:0000134
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
reversible: false
modifier: MODEL1310110033#
name: Heme oxygenase 1
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_ea68c469_c59b_476e_9ad8_8739f977cee0
name: GLS
type: Species
initial concentration: NaN
is: O94925
boundary condition: true
initial amount: NaN
is encoded by: hsa:2744
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_1c136c7d_b624_4ee4_94b3_9a227bad93e1
type: Species
is: B4DYG5
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: PI4KA
initial concentration: NaN
is encoded by: hsa:5297
has only substance units: false

metaR r2376
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
fast: false
reactant: MODEL1310110033#
reversible: true

metaM cholate r
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: cholate
is: CHEBI:29747
is: HMDB00619
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H39O5 CHARGE: -1 INCHI: InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_c9da3837_1ff6_445d_a435_535d79e7ab31
initial concentration: NaN
type: Species
is encoded by: hsa:39
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ACAT2
has only substance units: false
is: Q9BWD1

metaR RE3269C
type: Reaction
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.3.48
modifier: MODEL1310110033#
reversible: true
is: SBO:0000176
name: RE3269
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
fast: false

metaR ASPTAm
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110033#
type: Reaction
name: aspartate transaminase
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110033#
reversible: true

metaR AKGMALtm
type: Reaction
is described by: ECO:0000269
product: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
name: alpha-ketoglutarate/malate transporter
fast: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true

metaR RE1573M
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1573
product: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_1544d11b_407c_4409_a0da_c5a8ea9a364e
initial concentration: NaN
name: A4GNT
type: Species
is: SBO:0000252
constant: false
is: Q9UNA3
is encoded by: hsa:51146
initial amount: NaN
boundary condition: true
has only substance units: false

metaM nad n
type: Species
name: NAD(1-)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57540
constant: false
boundary condition: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: SBO:0000247
has only substance units: false
is: HMDB00902

metaR r1610
type: Reaction
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110033#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR PIPLC
name: phosphatidylinositol phospholipase C
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110033#
reversible: false
is: SBO:0000176
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
type: Reaction

metaM ksi deg24 l
name: keratan sulfate I, degradation product 24
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
is: CHEBI:12936
constant: false
is: HMDB00143
has only substance units: false
type: Species
boundary condition: false

metaR B3GALT41g
fast: false
modifier: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
name: Beta-1,3-galactosyltransferase 4
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.62
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110033#

metaM hs l
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: heparan sulfate, free chain
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
is: CHEBI:28815
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_24ed3878_c7ac_42fb_ae63_27da148a8b9f
initial concentration: NaN
type: Species
is encoded by: hsa:8818
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: O94777
name: DPM2

http://identifiers.org/biomodels.db/MODEL1310110033#_f08c0685_1320_4b71_83ea_351aa6e2276b
is: SBO:0000252
constant: false
is encoded by: hsa:5805
initial concentration: NaN
boundary condition: true
name: PTS
is: Q03393
has only substance units: false
type: Species
initial amount: NaN

metaR r2375
type: Reaction
reversible: true
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
reactant: MODEL1310110033#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_c52e68c4_5fc2_427a_8d3d_31ffff68e095
type: Species
constant: false
is: P50747
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3141
name: HLCS
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_dc35051b_6e39_40e6_ba43_c35a0a1d2ffc
name: CDIPT
type: Species
initial concentration: NaN
is encoded by: hsa:10423
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: O14735

metaM HC01401 x
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
initial concentration: 1.0
type: Species
name: (S)-3-Hydroxydodecanoyl-CoA
is: SBO:0000247
initial amount: NaN
is: CHEBI:27668

http://identifiers.org/biomodels.db/MODEL1310110033#_a4b4184e_2df2_47f5_82f8_42a74901a688
type: Species
is encoded by: hsa:10558
initial concentration: NaN
boundary condition: true
is: O15269
constant: false
is: SBO:0000252
initial amount: NaN
name: SPTLC1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_9c9770fe_6f2e_4140_8200_d196703c5fe9
boundary condition: true
name: NT5C2
has only substance units: false
is encoded by: hsa:22978
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: P49902

metaR GLNLASEer
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
name: gluconolactonase, endoplasmic reticulum
kinetic law: MODEL1310110033#

metaR PLA2 2
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
name: phospholipase A2
reversible: false
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.4

http://identifiers.org/biomodels.db/MODEL1310110033#_1b5b441e_1bfd_447e_8f3b_2f2c5e5b6c31
is encoded by: hsa:83884
initial concentration: NaN
boundary condition: true
is: Q9BXI2
is: SBO:0000252
name: SLC25A2
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM nad m
is: CHEBI:57540
type: Species
is: C00003
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00902
boundary condition: false

metaR r1611
reversible: true
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR UAG2EMAi
is described by: ECO:0000269
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
is: SBO:0000176
product: MODEL1310110033#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
reactant: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/5.1.3.14
type: Reaction

metaR S3TASE1ly
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
reactant: MODEL1310110033#
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
type: Reaction

metaR PSERT
is: SBO:0000176
fast: false
product: MODEL1310110033#
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.52
kinetic law: MODEL1310110033#
name: phosphoserine transaminase
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_25dab0f8_723b_4eeb_af27_f929772fc26a
is encoded by: hsa:D87002
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: _D87002_1_m
is: SBO:0000252

metaR ARACHDtr
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
name: intracellular transport
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reversible: true
is: SBO:0000185

metaR r0423
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
modifier: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
fast: false
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

http://identifiers.org/biomodels.db/MODEL1310110033#_cf2ffd9a_de6e_486b_91f7_34fea543f690
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:221823
is: P21108
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: PRPS1L1
constant: false

metaR URIt
is described by: ECO:0000269
reversible: true
product: MODEL1310110033#
type: Reaction
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000185
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
name: uridine facilated transport in cytosol
reactant: MODEL1310110033#

metaR r2378
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_3c55bb35_3a40_4973_bc43_5714b75c24d6
initial amount: NaN
boundary condition: true
name: EARS2
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q5JPH6
type: Species
has only substance units: false
is encoded by: hsa:124454

metaM dcyt c
has only substance units: false
initial amount: NaN
is: HMDB00014
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:15698
is: C00881
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
initial concentration: 1.0

metaM leuktrC4 c
boundary condition: false
is: HMDB01198
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
name: leukotriene C4(2-)

metaR r1612
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_f22b8c1e_2a31_4636_a73b_b0d4b143d04e
type: Species
is: SBO:0000252
is encoded by: hsa:7296
has only substance units: false
constant: false
initial amount: NaN
name: TXNRD1
is: Q16881
boundary condition: true
initial concentration: NaN

metaR PIACGT
modifier: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
is described by: ECO:0000000
type: Reaction
name: phosphatidylinositol N-acetylglucosaminyltransferase
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.1.83
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.1.198

metaR EBP1r
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.5
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
reversible: false
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
is described by: ECO:0000134
fast: false
is: SBO:0000176
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_fcecbe0f_196e_4e0a_b6c5_cbdbbab825f9
boundary condition: true
initial amount: NaN
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:516
initial concentration: NaN
constant: false
is: SBO:0000297
type: Species
has part: Q6FIH7

http://identifiers.org/biomodels.db/MODEL1310110033#_855e6411_6a99_4b7d_834e_74cdd1d280f9
initial concentration: NaN
is: O14521
name: SDHD
is encoded by: hsa:6392
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaR r2377
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
type: Reaction

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

metaR r1613
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_cdb8ed8a_9fe2_4326_9232_24b2432117cd
is encoded by: hsa:23428
has only substance units: false
has part: Q9UHI5
name: SLC7A8:SLC3A2
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000297
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_9883ed05_dcf2_4017_abc1_888ec2282bf5
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: P41222
is encoded by: hsa:5730
name: PTGDS
boundary condition: true
initial concentration: NaN

metaR r0425
is: SBO:0000176
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
fast: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.17.1.4
type: Reaction
name: EC:1.1.1.42
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#

metaM ksii core2 deg8 l
is: HMDB00143
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 8
boundary condition: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_31141ac6_b60a_42a1_87f8_213073fc0dd6
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10587
constant: false
type: Species
initial amount: NaN
name: TXNRD2

metaM fad e
initial concentration: 1.0
boundary condition: false
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
is: C00016
type: Species
is: HMDB01248
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_7194d32c_46a4_4e13_bbf0_6a425223bbf9
constant: false
is: SBO:0000252
is: O00750
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5287
type: Species
name: PIK3C2B
boundary condition: true

metaM nad r
is: HMDB00902
name: NAD(1-)
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57540
constant: false

metaR PDE1
kinetic law: MODEL1310110033#
name: 3',5'-cyclic-nucleotide phosphodiesterase
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.35
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.17
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
is: SBO:0000176
fast: false

metaM pyam5p c
is: HMDB01555
initial concentration: 1.0
is: C00647
boundary condition: false
name: Pyridoxamine 5'-phosphate
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58451

metaR HS3ly
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110033#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110033#
reversible: false

metaR CYTK12n
name: cytidylate kinase (dCMP,dCTP),nuclear
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110033#
type: Reaction

metaR RE1807C
name: RE1807
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110033#

metaR r0424
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/1.17.1.4
type: Reaction
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_0b9c46f8_71ed_4145_ad3d_911c631ad80c
boundary condition: true
is: Q9NRA2
is encoded by: hsa:26503
constant: false
type: Species
name: SLC17A5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM pe hs e
name: phosphatidylethanolamine
initial concentration: 1.0
constant: false
is: CHEBI:16038
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_1f94df2b_b9f5_4c22_8c8d_08d18378f6c7
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5140
is: A7E2E5
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: PDE3B

metaM r1p c
is: HMDB01489
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: alpha-D-Ribose 1-phosphate
is: SBO:0000247
type: Species
is: CHEBI:57720
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: C00442

metaM 2dr1p c
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
constant: false
is: CHEBI:58576
name: 2-Deoxy-D-ribose 1-phosphate
is: HMDB01351
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: C00672
initial concentration: 1.0

metaR r2379
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f4810509_c43a_4f1c_ac1b_026bcb092614
is: P05187
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:250
name: ALPP

metaR RE1530C
name: RE1530
is described by: ECO:0000000
reversible: true
product: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_e2f41193_f2ab_4f41_811b_8624358029b1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: RDH12
has only substance units: false
is: Q96NR8
type: Species
constant: false
is encoded by: hsa:145226
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_e05e6150_4ead_4869_8033_579c83cec1ba
constant: false
name: ACOT7
is: O00154
type: Species
is encoded by: hsa:11332
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM hs deg17 l
initial amount: NaN
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: SBO:0000247
has only substance units: false
name: heparan sulfate, degradation product 17
is: HMDB02704
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:21338

metaR GALASE11ly
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110033#
is described by: ECO:0000000

metaR CYOOm3
reactant: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/1.9.3.1
name: cytochrome c oxidase, mitochondrial Complex IV
is: SBO:0000185
product: MODEL1310110033#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
modifier: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_febddaae_7d66_4233_8f0e_dcf4c18acf5d
is encoded by: hsa:51727
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: CMPK1
boundary condition: true
is: B2R6S5

http://identifiers.org/biomodels.db/MODEL1310110033#_efefb5e4_1228_47e3_aaf6_bb18de9c2ce0
name: BCKDHB
type: Species
initial amount: NaN
is: P21953
initial concentration: NaN
boundary condition: true
is encoded by: hsa:594
constant: false
has only substance units: false
is: SBO:0000252

metaR r0426
product: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.34
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000176
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110033#_80d5f0b1_cefe_415e_842e_97f6a1f42b47
initial concentration: NaN
boundary condition: true
is: Q9P0J0
name: NDUFA13
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:51079
initial amount: NaN
type: Species

metaM C05280 m
type: Species
has only substance units: false
is: HMDB03952
is: CHEBI:28002
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
name: cis,cis-3,6-Dodecadienoyl-CoA

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM pe hs c
constant: false
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: CHEBI:16038
is: SBO:0000247
name: phosphatidylethanolamine
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_a9b911e1_0a65_422f_b0f2_48484b58210b
is: SBO:0000252
is: O76082
constant: false
initial amount: NaN
boundary condition: true
name: SLC22A5
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6584

http://identifiers.org/biomodels.db/MODEL1310110033#_8192dac6_57b8_4371_98ac_5b63fc269fc0
is encoded by: hsa:8871
constant: false
is: O15056
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: SYNJ2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_ea3268ff_e5a3_487a_8bf2_ca75eafd79bd
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110033#_eefe9304_1378_46ea_b027_0a6c85d691a8
is: SBO:0000297
is encoded by: hsa:5277
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8818
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true
has part: P37287

http://identifiers.org/biomodels.db/MODEL1310110033#_0755c988_fe51_40ed_b417_06460e2521d5
boundary condition: true
is: P56381
type: Species
constant: false
is encoded by: hsa:514
is: SBO:0000252
has only substance units: false
name: ATP5E
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_0ef2e841_de67_49bf_8424_30bd3ab4fae4
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:223
name: ALDH9A1
constant: false
is: P49189

metaM xtsn c
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00299
name: xanthosine
boundary condition: false
has only substance units: false
is: CHEBI:18107
type: Species

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM ksii core2 deg6 l
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 6
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00143
notes: FORMULA: C44H72N4O33SX CHARGE: -1
type: Species
initial amount: NaN
is: CHEBI:12936
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_0b526349_4355_4ab8_9ff2_8cbe5b72d41d
is encoded by: hsa:5289
name: PIK3C3
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q8NEB9
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_13620a1f_099f_485e_8256_6f94296d5904
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:10317
name: B3GALT5
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_aa0a3b20_ff97_4fcc_abe1_12733378c3d1
is encoded by: hsa:1327
name: COX4I1
is: SBO:0000252
constant: false
boundary condition: true
is: P13073
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_95bb08d5_1722_48a7_9114_6119087c0924
type: Species
name: SLC16A2
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6567
boundary condition: true
is: P36021
initial amount: NaN

metaR CHOLtn
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
name: Choline transport, nuclear through pores
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185

metaR r0139
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000176

metaR PROSTGF2t
reversible: true
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
product: MODEL1310110033#
reactant: MODEL1310110033#
name: prostaglandin uniport

metaM HC01412 x
constant: false
is: CHEBI:61405
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
name: trans-tetradec-2-enoyl-CoA(4-)
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM Lkynr c
constant: false
is: HMDB00684
is: SBO:0000247
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: L-kynurenine
type: Species
has only substance units: false
is: CHEBI:16946

metaR 7DHCHSTEROLtr
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110033#
name: cholesterol precursor intracellular transport
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
reversible: true
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_d999c05e_fb9e_4d1d_bd71_055ad5a5f233
has only substance units: false
name: _AI091231_1_c
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI091231
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_49eec710_8b3f_45c2_b4c3_8157c1846baf
boundary condition: true
is encoded by: hsa:56606
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: SLC2A9
initial concentration: NaN
has only substance units: false

metaM gm2 hs g
is: SBO:0000247
constant: false
is: CHEBI:58857
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C49H85N3O25FULLRCO CHARGE: -1
boundary condition: false
name: N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminosyl-(2->3)]-beta-D-galactosyl-beta-D-glucosyl-(1<->1)-ceramide anion
type: Species

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR MI145PP
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
product: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.3.56
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000269
name: inositol-1,4,5-trisphosphate 5-phosphatase

metaR C6DCe
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of adipoyl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_14532003_c437_4171_8c49_3fe761cbf0a9
type: Species
is: SBO:0000252
initial amount: NaN
name: GBA
boundary condition: true
is encoded by: hsa:2629
has only substance units: false
constant: false
initial concentration: NaN
is: B7Z5G2

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR RIBt
reactant: MODEL1310110033#
type: Reaction
name: ribose transport via diffusion
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_5ba891a8_e691_40eb_8eba_e2dd392b89f2
type: Species
name: COX6A1
boundary condition: true
initial concentration: NaN
is: P12074
is encoded by: hsa:1337
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR r2497
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
fast: false
kinetic law: MODEL1310110033#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: false
product: MODEL1310110033#

metaR LEUKTRE4t
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
name: leukotriene E4 transport
reactant: MODEL1310110033#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110033#

metaM arach c
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: CHEBI:32360
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: arachidate
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02212

metaM cs e deg1 l
is: HMDB00868
type: Species
constant: false
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
initial concentration: 1.0
is: CHEBI:57737
has only substance units: false
boundary condition: false
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
is: SBO:0000247

metaM udpacgal g
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57847
name: UDP-N-acetyl-D-galactosamine(2-)
has only substance units: false
constant: false
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR FBP
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110033#
name: fructose-bisphosphatase
modifier: MODEL1310110033#
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
is version of: http://identifiers.org/ec-code/3.1.3.11
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_c935b74d_27bb_465d_83c1_88650d8e9476
initial amount: NaN
boundary condition: true
is: P18283
name: GPX2
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:2877

metaM ksi deg10 l
boundary condition: false
is: HMDB01354
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:57455
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
name: keratan sulfate I, degradation product 10

metaR FADH2tx
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: FADH2 transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reactant: MODEL1310110033#

metaM dcdp c
is: C00705
is: CHEBI:58593
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01245
name: dCDP
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
initial concentration: 1.0

metaR ESTRADIOLtr
type: Reaction
is: SBO:0000185
name: estradiol intracellular transport
reactant: MODEL1310110033#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_80b81afe_f21f_4e26_8732_847e1a24d08a
is encoded by: hsa:84720
has only substance units: false
constant: false
boundary condition: true
is: Q8TEQ8
initial concentration: NaN
type: Species
is: SBO:0000252
name: PIGO
initial amount: NaN

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

metaM omhpal r
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
initial concentration: 1.0
name: w-hydroxypalmiticacid
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB06294
is: SBO:0000247

metaR CSPG Etly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000185
fast: false
product: MODEL1310110033#
name: chondroitin sulfate E transport, extracellular to lysosome
reversible: false

metaM oaa c
is: CHEBI:3338
name: Oxaloacetate
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C4H2O5 CHARGE: -2
is: C00036
initial concentration: 1.0
is: HMDB00223

http://identifiers.org/biomodels.db/MODEL1310110033#_0e0a7c89_86c2_4ce8_ab44_fde7f9b46d50
is: SBO:0000252
is encoded by: hsa:5860
type: Species
constant: false
boundary condition: true
is: P09417
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: QDPR

http://identifiers.org/biomodels.db/MODEL1310110033#_0e849dbe_2dc9_440f_97f7_ae7372496350
is encoded by: hsa:3418
is: SBO:0000252
is: P48735
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: IDH2
initial concentration: NaN

metaM thbpt4acam c
type: Species
is: HMDB02281
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaM cholate e
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00619
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:29747

W3 CDTF: Thu Aug 30 10:41:37 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110033#_ae543156_b162_41e4_adf3_5037075edb14
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:5169
has only substance units: false
is: Q308M7
initial amount: NaN
name: ENPP3
type: Species

metaM CE1926 e
name: gama-carboxyethyl-hydroxychroman
boundary condition: false
initial amount: NaN
is: HMDB00127
constant: false
is: CHEBI:15748
has only substance units: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR GDPtg
reactant: MODEL1310110033#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: GDP intracellular transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
kinetic law: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_cf141e6d_36d4_453b_91fb_1dff186fbc31
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_d362b3a5_b629_4bb1_88e4_917f5e10583d
is encoded by: hsa:1854
name: DUT
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P33316
type: Species
has only substance units: false
constant: false
boundary condition: true

metaR NDPK5n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
is: SBO:0000176
product: MODEL1310110033#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
reactant: MODEL1310110033#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#

metaM arach e
name: arachidate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB02212
has only substance units: false
is: CHEBI:32360
constant: false

metaM 5adtststerones c
is: HMDB06278
constant: false
initial concentration: 1.0
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

W3 CDTF: Thu Aug 30 10:41:37 BST 2012

metaR r0022
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.8.1.7

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110033#

metaM f1p c
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
name: D-Fructose 1-phosphate
is: C01094
is: CHEBI:18105
is: HMDB01076
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

metaR PI345P3P
modifier: MODEL1310110033#
is described by: ECO:0000000
reversible: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.67
fast: false
reactant: MODEL1310110033#
type: Reaction

metaR r0021
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false

metaR LALDO
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
type: Reaction
is: SBO:0000176
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: true
modifier: MODEL1310110033#

metaR RDH2a
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.105
is: SBO:0000176
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000269
name: retinol dehydrogenase (9-cis,NADPH)
type: Reaction
fast: false
reversible: true

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_793692b6_5ffd_43db_beae_bf73f8638d4a
constant: false
boundary condition: true
initial amount: NaN
name: CA6
is: Q5FC00
is encoded by: hsa:765
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_f316fbf3_182c_4c96_9f17_32b8c65d42d5
is: SBO:0000252
is: O95573
type: Species
is encoded by: hsa:2181
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: ACSL3
boundary condition: true

metaM psylchol e
initial concentration: 1.0
is: SBO:0000247
type: Species
name: psillium-glycocholic acid complex
has only substance units: false
is: HMDB03402
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0

metaM cholate c
is: SBO:0000247
name: Cholate
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:29747
boundary condition: false
is: HMDB00619
has only substance units: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695

http://identifiers.org/biomodels.db/MODEL1310110033#_c9900a28_4755_4f2c_a306_85bb4121e60c
is encoded by: hsa:10935
initial concentration: NaN
is: E9PH29
has only substance units: false
constant: false
name: PRDX3
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

metaM 5adtststerones e
is: HMDB06278
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 5alpha-Dihydrotestosterone sulfate
type: Species
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_75448e2e_fb02_418b_b8f1_8db2ac601a57
type: Species
is: SBO:0000252
boundary condition: true
is: P24310
is encoded by: hsa:1346
has only substance units: false
initial concentration: NaN
name: COX7A1
constant: false
initial amount: NaN

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM udpacgal l
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00304
type: Species

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM biocyt m
constant: false
name: Biocytin
has only substance units: false
boundary condition: false
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
type: Species
is: HMDB03134
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_1e5bce4f_26fd_4407_839a_9055d2f813b7
has only substance units: false
is encoded by: hsa:4830
name: NME1:NME2
is encoded by: hsa:4831
boundary condition: true
constant: false
initial concentration: NaN
has part: P15531
has part: P22392
initial amount: NaN
type: Species
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110033#_f1e08f6e_a8d4_4545_a27e_a4707c85d136
is encoded by: hsa:2720
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000297
has part: P34059
has only substance units: false
has part: P10619
is encoded by: hsa:2588
constant: false
has part: Q99519
has part: P16278
is encoded by: hsa:5476
is encoded by: hsa:4758
name: GALNS:GLB1:NEU1:CTSA
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_aa6dfdb3_5a98_4266_b539_83c03810259f
is: SBO:0000252
constant: false
is encoded by: hsa:220
type: Species
initial amount: NaN
has only substance units: false
name: ALDH1A3
initial concentration: NaN
boundary condition: true
is: P47895

http://identifiers.org/biomodels.db/MODEL1310110033#_ed26707f_c4f5_4747_af4b_0ce45d7d0a33
constant: false
is: SBO:0000252
is encoded by: hsa:BG035985
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: _BG035985_1_c
has only substance units: false

metaR DM oretn n
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 4-oxo-retonoic acid demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_fbe8002f_a57c_49a0_8c43_bc07b58edc92
boundary condition: true
is: SBO:0000252
name: GCK
is encoded by: hsa:2645
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaR MI1PS
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.5.1.4
kinetic law: MODEL1310110033#
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
name: myo-Inositol-1-phosphate synthase

http://identifiers.org/biomodels.db/MODEL1310110033#_3b7d2b81_e296_4c73_9c4a_a7a8dad9041c
name: SCP2
boundary condition: true
is: C9JC79
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:6342
initial concentration: NaN
is: SBO:0000252

metaM dcdp m
constant: false
boundary condition: false
initial amount: NaN
name: dCDP(3-)
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01245

metaR ACNAMtn
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110033#
name: N-acetylneuraminate nuclear import
reactant: MODEL1310110033#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f2026caa_9133_4e08_9281_10fd868a7ba0
is encoded by: hsa:23428
is: Q86U05
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: SLC7A8
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r0027
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
fast: false
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
reactant: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.14.13.39
reversible: true
is described by: ECO:0000000
type: Reaction

metaR UMPK3n
is: SBO:0000176
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110033#
name: UMP kinase (UTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR DOPASFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
product: MODEL1310110033#
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
type: Reaction
name: Dopamine 3-0-sulfate transport (diffusion)

metaM fgam c
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:58426
initial amount: NaN
is: C04376
boundary condition: false
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: HMDB01308
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
constant: false
is: SBO:0000247

metaM glyphe c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H14N2O3 CHARGE: 0
boundary condition: false
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/97415
name: Glycylphenylalanine
initial concentration: 1.0
initial amount: NaN

metaM creat e
is: CHEBI:16919
initial concentration: 1.0
is: HMDB00064
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
initial amount: NaN
name: creatine

metaM apoC c
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: XH CHARGE: 0
initial concentration: 1.0
initial amount: NaN
name: Apocarboxlase (no lys residue)
is: HMDB11111
constant: false
boundary condition: false
is: CHEBI:33190

metaM ala B c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
boundary condition: false
is: CHEBI:16958
initial concentration: 1.0
type: Species
is: SBO:0000247
name: beta-alanine
constant: false
has only substance units: false
initial amount: NaN

metaM 3hbcoa m
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial amount: NaN
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: CHEBI:57316
type: Species
constant: false
is: HMDB01166
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_0295520e_196d_476a_90e9_564552e7069c
name: SKIV2L2
is: Q3MHC9
is encoded by: hsa:23517
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaM dcdp n
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58593
is: HMDB01245
name: dCDP(3-)
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
is: SBO:0000247

metaR DNDPt10m
is described by: ECO:0000269
kinetic law: MODEL1310110033#
name: dADP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
modifier: MODEL1310110033#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
reversible: false
product: MODEL1310110033#

metaM psyl e
is: SBO:0000247
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
is: HMDB03402
initial concentration: 1.0
initial amount: NaN
name: psyllium
type: Species

metaR r0130
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000176

metaR IDOURte
reversible: true
type: Reaction
fast: false
name: L-iduronate transport, extracellular
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_0bf545b4_c78e_4175_bc32_690f51972e1d
is encoded by: hsa:4190
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: B7Z3I7
name: MDH1
initial concentration: NaN
boundary condition: true

metaM cholcoads x
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:27505
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
type: Species
is: SBO:0000247
is: HMDB06889

metaR RE2269E
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.4.21.39
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
name: RE2269

metaR ESTRADIOLt
is described by: ECO:0000000
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
name: estradiol transport
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
reversible: true

metaM sT antigen g
constant: false
notes: FORMULA: C25H40N2O18X CHARGE: -1
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: sialyl-T antigen
initial concentration: 1.0
is: CHEBI:16565
boundary condition: false

metaM leuktrC4 e
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57973
is: HMDB01198
name: leukotriene C4(2-)
has only substance units: false
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial amount: NaN
initial concentration: 1.0

metaR HEX1
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-glucose:ATP)
reversible: false
reactant: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1
is described by: ECO:0000134
product: MODEL1310110033#

metaM cgly e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:4047
has only substance units: false
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: SBO:0000247
name: L-cysteinylglycine
is: HMDB00078
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_f0165c56_1529_4262_8438_f5ad991ec229
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: P35218
name: CA5A
initial amount: NaN
is encoded by: hsa:763

metaR NACHEX23ly
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
kinetic law: MODEL1310110033#
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110033#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_dbe37b03_600c_443d_a972_ce7eb620c0ae
is encoded by: hsa:112
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ADCY6
type: Species
initial concentration: NaN

metaM thbpt4acam n
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
constant: false
initial amount: NaN
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
is: CHEBI:15374
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM creat c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16919
is: HMDB00064
has only substance units: false
boundary condition: false
type: Species
name: creatine
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300

metaR CHOLtu
name: Choline uniport
reversible: true
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
type: Reaction

metaM glyphe e
has only substance units: false
constant: false
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/97415
name: Glycylphenylalanine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_2dc94c38_4a2e_45c8_afb0_b30f98577202
is: SBO:0000252
boundary condition: true
type: Species
is: Q6P1K9
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:80025
has only substance units: false
name: PANK2

http://identifiers.org/biomodels.db/MODEL1310110033#_4be8ffc3_442d_4b6d_854d_b105f862b7b8
initial amount: NaN
type: Species
is encoded by: hsa:341947
boundary condition: true
is: SBO:0000252
name: COX8C
is: Q7Z4L0
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_66898a22_b79f_49de_aa61_ae5fc67bca6a
is: Q16878
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: CDO1
is encoded by: hsa:1036
has only substance units: false

metaR MI1PP
is version of: http://identifiers.org/ec-code/3.1.3.25
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
product: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
name: myo-inositol 1-phosphatase
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false

metaR RE1527M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
name: RE1527
modifier: MODEL1310110033#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_c58c1fb0_5e13_4e55_a647_1ce8ac1a10db
constant: false
has only substance units: false
name: CMAS
is: SBO:0000252
initial amount: NaN
is: Q8NFW8
is encoded by: hsa:55907
type: Species
boundary condition: true
initial concentration: NaN

metaR DHCR72r
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
is described by: ECO:0000269
name: 7-dehydrocholesterol reductase
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.1.21
is: SBO:0000176
kinetic law: MODEL1310110033#
type: Reaction

metaM vitd3 e
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial concentration: 1.0
name: calciol
is: HMDB00876
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: CHEBI:28940

metaR PSYGCHe
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_3f694c76_01f4_48c0_8abe_a8d461505da6
is: SBO:0000252
has only substance units: false
constant: false
is: Q6I9V2
type: Species
is encoded by: hsa:509
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ATP5C1

metaM prostgf2 c
name: prostaglandin F2alpha(1-)
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01139
is: CHEBI:57404
type: Species
initial amount: NaN
constant: false
boundary condition: false

metaR r0295
modifier: MODEL1310110033#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176

metaM cgly c
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:4047
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
is: SBO:0000247
constant: false
is: HMDB00078
boundary condition: false

metaM o2s m
name: Superoxide anion
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:18421
initial amount: NaN
is: C00704
is: HMDB02168
type: Species

metaM nad x
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00902
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
type: Species
is: SBO:0000247
is: CHEBI:57540
constant: false
is: C00003
name: Nicotinamide adenine dinucleotide

metaM HC02214 e
constant: false
is: CHEBI:28852
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: prostaglandin-f1alpha
is: SBO:0000247
boundary condition: false

metaR r0842
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
modifier: MODEL1310110033#
product: MODEL1310110033#
reversible: true
fast: false
kinetic law: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
name: Postulated transport reaction
reactant: MODEL1310110033#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_b4cec005_2fb8_48ea_af9e_474fae7bf694
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8818
name: DPM2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_291d6c05_def4_4c97_b180_ea27fadcbcc1
is: SBO:0000252
boundary condition: true
is: Q8N9L9
initial amount: NaN
type: Species
name: ACOT4
is encoded by: hsa:122970
constant: false
initial concentration: NaN
has only substance units: false

metaM HC01401 m
constant: false
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:27668
initial amount: NaN

metaR 5MTHFt2le
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110033#
name: 5-methyltetrahydrofolate transport via anion exchange

metaM HC01602 c
type: Species
is: SBO:0000247
is: C00234
name: 10-Formyltetrahydrofolate
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_c54127a5_524f_46ac_a364_e1109f8b9874
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: DGUOK
is encoded by: hsa:1716

http://identifiers.org/biomodels.db/MODEL1310110033#_078cd3dd_a50b_446a_9860_c2cc0c4954af
type: Species
initial concentration: NaN
is: Q9UN76
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11254
constant: false
name: SLC6A14
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_b694ac86_295e_4014_813d_66476599efc2
is encoded by: hsa:5296
boundary condition: true
has part: O00459
type: Species
has only substance units: false
has part: P42336
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
name: PIK3CA:PIK3R2
constant: false
is encoded by: hsa:5290

metaM vitd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: HMDB00876
initial amount: NaN
initial concentration: 1.0
name: calciol
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:28940
has only substance units: false

metaR EX alaala LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for alanylalanine
type: Reaction

metaM prostgf2 e
boundary condition: false
name: prostaglandin F2alpha(1-)
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
initial concentration: 1.0
is: HMDB01139
is: CHEBI:57404
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_08fde355_24de_48fb_834c_dbf9c448b574
name: SLC4A5
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:57835
has only substance units: false

metaR r1670
name: Y+LAT2 Utilized transport
reactant: MODEL1310110033#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#
fast: false

metaR EX gq1b hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GQ1b (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_0d6ee2c3_b199_474a_9494_c4acd877c95c
type: Species
constant: false
is encoded by: hsa:100287639
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _100287639_1_c

metaM man l
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
boundary condition: false
is: HMDB00169
is: CHEBI:16024

metaM HC02214 c
name: prostaglandin-f1alpha
type: Species
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:28852
has only substance units: false

metaR SPHS1Pte
reactant: MODEL1310110033#
product: MODEL1310110033#
name: sphingosine-1-phosphate transport
is: SBO:0000185
kinetic law: MODEL1310110033#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR HEX4
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is described by: ECO:0000304
product: MODEL1310110033#
name: hexokinase (D-mannose:ATP)
type: Reaction

metaR r1671
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110033#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000

metaM gal c
is: C00124
has only substance units: false
is: HMDB00143
name: D-Galactose
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:0

metaR r1621
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_65374986_4143_4672_8965_7c11bad2ff6b
is encoded by: hsa:6550
constant: false
name: SLC9A3
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P48764
type: Species
initial concentration: NaN
initial amount: NaN

metaR ASCBt4
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
fast: false
is: SBO:0000185
type: Reaction
name: L-ascorbate transport via proton symport
is described by: ECO:0000269
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_56d582c4_d916_4806_b8d4_3b8384236781
has only substance units: false
boundary condition: true
is encoded by: hsa:6120
initial concentration: NaN
constant: false
type: Species
is: Q96AT9
name: RPE
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_55c9602d_6e9d_4c85_8a5e_33afd4ced946
initial concentration: NaN
name: PFKL
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:5211
is: P17858
has only substance units: false

metaR PAIL4P HStn
type: Reaction
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
reversible: true
product: MODEL1310110033#

metaR PDX5PO
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is: SBO:0000176
name: pyridoxine 5'-phosphate oxidase
is described by: ECO:0000269
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#

metaR S2TASE3ly
reversible: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
name: iduronate-2-sulfatase, lysosomal

metaR r1620
is: SBO:0000185
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110033#_10502984_7f8d_4425_b88b_8f1ba8fd1639
is encoded by: hsa:27232
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: GNMT
constant: false
is: Q14749
type: Species
initial amount: NaN

metaR MI1345PP
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
type: Reaction
fast: false
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_76cf902c_eb57_4c20_8494_3def2a9dff5d
type: Species
constant: false
boundary condition: true
name: ACSL6
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: B2RB13
is encoded by: hsa:23305

http://identifiers.org/biomodels.db/MODEL1310110033#_70fb035a_7c51_4aa4_9d02_e27ba8bf60e6
name: PLCG1
is encoded by: hsa:5335
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: P19174
has only substance units: false
initial amount: NaN
boundary condition: true

metaM 3hibutcoa m
is: SBO:0000247
type: Species
name: (S)-3-Hydroxyisobutyryl-CoA
is: CHEBI:28259
is: HMDB01052
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_02cb7c03_931a_4e87_a382_397804608405
initial amount: NaN
type: Species
is: Q9NRD9
name: DUOX1
constant: false
is: SBO:0000252
is encoded by: hsa:53905
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR SIAT4Bg
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
product: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.4
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
fast: false
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110033#_beaf71bd_5ca0_4f2a_8ae8_88afb0692373
is: SBO:0000252
type: Species
initial amount: NaN
name: CRAT
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1384
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_2a68d4a7_95f1_4992_ad84_b969ddf650b7
type: Species
name: GOT1
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2805
is: P17174
boundary condition: true

metaR CYTDtm
fast: false
is: SBO:0000185
is described by: ECO:0000269
name: cytidine facilated transport in mitochondria
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
type: Reaction
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110033#

metaR FUCASE2ly
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#
name: alpha-fucosidase, lysosomal
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_c4e43ae8_1d18_46f6_bb03_56f7695857ba
initial amount: NaN
is: P24752
name: ACAT1
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:38
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_30cdd437_d28b_49ff_87b8_fac4471ef431
type: Species
has only substance units: false
is encoded by: hsa:8869
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: ST3GAL5
is: Q9UNP4

http://identifiers.org/biomodels.db/MODEL1310110033#_44196aa3_74cf_42dd_ac0b_522715b68af0
type: Species
initial concentration: NaN
is encoded by: hsa:5321
boundary condition: true
name: PLA2G4A
is: P47712
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_c5d39a1d_6a57_4aa4_b382_e03a62db1e18
boundary condition: true
is: E2QRH8
initial amount: NaN
is encoded by: hsa:5332
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: PLCB4

metaR Ser Thrtg
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
reversible: true
name: Ser/Thr transport (from golgi to lysosome)
product: MODEL1310110033#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_19ad2269_2c1b_44ca_9b36_de653e42e0c0
initial amount: NaN
type: Species
is: P35557
boundary condition: true
is encoded by: hsa:2645
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: GCK
constant: false

metaR UDPtl
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
name: udp intracellular transport
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ

metaR HISSNAT5tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_0dae0150_decf_45ec_8cec_df2aa5425361
is encoded by: hsa:3948
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: P07864
has only substance units: false
name: LDHC

metaR r0990
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110033#
name: Postulated transport reaction
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_c4c6db3d_71ab_468e_a1f1_b3837ac2c99d
is: A8MU28
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8883
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: NAE1

metaM 2mop c
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: HMDB01172
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
name: 2-methyl-3-oxopropanoate
is: SBO:0000247
constant: false
is: CHEBI:57700

metaR PCRNtm
name: transport into the mitochondria from cytosol (carnitine)
fast: false
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
is: SBO:0000185
reversible: false

metaR S6TASE13ly
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_776b6907_5fa3_4ced_8553_6fc64e7c9735
name: LDHD
boundary condition: true
initial concentration: NaN
is encoded by: hsa:197257
is: Q86WU2
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR RE1836X
name: RE1836
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.176

http://identifiers.org/biomodels.db/MODEL1310110033#_0f533d21_023c_4e6e_92cd_ac3b53cb7e68
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1593
initial concentration: NaN
has only substance units: false
name: CYP27A1
is: Q02318
constant: false

metaR r1625
kinetic law: MODEL1310110033#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_d5061cc8_144d_4fd7_a9e0_30f0794a5d24
type: Species
boundary condition: true
initial amount: NaN
name: _LOC727762_1_m
constant: false
is encoded by: hsa:LOC727762
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_5ab06f53_dc2c_4454_b5c8_527544d6d502
is encoded by: hsa:3038
has only substance units: false
name: HAS3
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: O00219
constant: false

metaR r0410
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reactant: MODEL1310110033#
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_fbb2fb25_a12a_4f18_9063_e25416fb0067
boundary condition: true
constant: false
is: Q7GXY8
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4512
is: SBO:0000252
name: COX1
initial amount: NaN

metaR r1669
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: Y+LAT2 Utilized transport

metaM ha pre1 l
name: hyaluronan biosynthesis, precursor 1
initial amount: NaN
constant: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
type: Species
has only substance units: false
is: CHEBI:16126
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a08e22de_9388_4eaf_b8c7_bef032a9adf8
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: DGUOK
is encoded by: hsa:1716
is: E5KSL6
constant: false
type: Species
boundary condition: true

metaM tymsf c
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Tyramine O-sulfate
type: Species
is: HMDB06409
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_e8000ba7_4f18_4f4b_8730_e96f9513d8fd
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AF080579
name: _AF080579_1_c
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r0995
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaR AGTim
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.44
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_299969bc_5e90_4648_a273_47430949b8f9
name: _AI601100_1_m
is encoded by: hsa:AI601100
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false

metaR OCDCEAtr
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
name: fatty acid transport via diffusion
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR PIter
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
is described by: ECO:0000212
name: phosphate transport, endoplasmic reticulum
reactant: MODEL1310110033#
is: SBO:0000185
type: Reaction
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
reversible: true

metaR CSNATm
is: SBO:0000176
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110033#
reversible: true
name: carnitine O-aceyltransferase, mitochondrial
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
modifier: MODEL1310110033#

metaR r1624
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM 1pyr5c m
constant: false
is: HMDB01301
initial amount: NaN
initial concentration: 1.0
name: 1-Pyrroline-5-carboxylate
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: SBO:0000247
is: C03912
is: CHEBI:15893
has only substance units: false
type: Species
boundary condition: false

metaM 1p3h5c m
initial concentration: 1.0
initial amount: NaN
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: CHEBI:6151
boundary condition: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaR r1668
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_0db26634_023b_4ae0_b971_7af3a5037934
initial amount: NaN
constant: false
name: ATP5G2
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:517
boundary condition: true
is: SBO:0000252

metaR GALASE8ly
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
product: MODEL1310110033#
fast: false
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110033#_37d28217_1bde_4b4d_b0b2_d70a1e596a33
has only substance units: false
name: GALNT1
type: Species
initial concentration: NaN
is encoded by: hsa:2589
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: Q10472

metaR r1623
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
type: Reaction
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
reversible: true

metaM gal e
type: Species
is: HMDB00143
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
is: SBO:0000247
boundary condition: false
name: D-Galactose
is: CHEBI:0
initial concentration: 1.0
is: C00124

metaR IDPtn
is: SBO:0000185
reactant: MODEL1310110033#
name: IDP nuclear transport
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR GGLUCT
kinetic law: MODEL1310110033#
name: gamma-glutamylcyclotransferase
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.2.4
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
is: SBO:0000185
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000269

metaM tymsf e
has only substance units: false
constant: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
boundary condition: false
is: SBO:0000247
is: HMDB06409
initial amount: NaN
initial concentration: 1.0
type: Species
name: Tyramine O-sulfate

metaR r1667
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110033#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_f85ddc83_5059_4eb6_803a_d09ca6a9faa8
is encoded by: hsa:686
initial concentration: NaN
constant: false
name: BTD
type: Species
is: P43251
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR RE2998M
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE2998
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#

metaR r0993
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is: SBO:0000185
fast: false
reactant: MODEL1310110033#
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
is described by: ECO:0000000

metaM na1 c
boundary condition: false
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
initial concentration: 1.0
is: HMDB00588
is: CHEBI:4541
constant: false
has only substance units: false
type: Species
is: C01330
name: Sodium
is: SBO:0000247

metaR r1622
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_a7215ef4_42f4_4980_8275_a5ab8dffe689
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:M68895
name: _M68895_1_c
is: SBO:0000252
type: Species
boundary condition: true

metaR RE0935E
modifier: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0935
type: Reaction
reversible: true
reactant: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_7450f177_b948_4637_87d5_ecf54dcf8641
is: Q08499
boundary condition: true
name: PDE4D
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:5144
initial amount: NaN

metaM zymst r
initial amount: NaN
name: zymosterol
is: HMDB06271
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:18252

http://identifiers.org/biomodels.db/MODEL1310110033#_59369146_879b_4e98_9e27_f5754cee7f81
constant: false
initial amount: NaN
is encoded by: hsa:3613
type: Species
name: IMPA2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is: O14732

metaM ala L m
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: HMDB00161
boundary condition: false
initial concentration: 1.0
name: L-alanine
type: Species
initial amount: NaN
is: CHEBI:16977
constant: false
has only substance units: false
is: SBO:0000247

metaM omhpal c
has only substance units: false
notes: FORMULA: C16H30O3 CHARGE: -1
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: w-hydroxypalmiticacid
initial amount: NaN
is: HMDB06294

metaR ACETONEt2m
fast: false
name: acetone mitochondrial transport via proton symport
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110033#
reversible: true

metaR r1666
is: SBO:0000185
modifier: MODEL1310110033#
product: MODEL1310110033#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction

metaR FUMAC
kinetic law: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110033#
is: SBO:0000176
reversible: false
name: fumarylacetoacetase
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.7.1.2
type: Reaction
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_eb7762f3_f0e3_4221_bb36_034aa5b0d0be
is: P30613
initial concentration: NaN
constant: false
is encoded by: hsa:5313
name: PKLR
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species

metaR r0994
type: Reaction
name: Facilitated diffusion
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_567bdb37_e772_40f1_a333_0d9207b98cd0
initial amount: NaN
is: SBO:0000252
name: AUH
initial concentration: NaN
boundary condition: true
is encoded by: hsa:549
type: Species
constant: false
is: Q13825
has only substance units: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaM na1 e
boundary condition: false
is: CHEBI:4541
name: Sodium
initial amount: NaN
is: SBO:0000247
is: C01330
initial concentration: 1.0
is: HMDB00588
has only substance units: false
type: Species
constant: false
notes: FORMULA: Na CHARGE: 1

metaR r0999
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
kinetic law: MODEL1310110033#
name: Facilitated diffusion
is: SBO:0000185
product: MODEL1310110033#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_74e89086_1e16_4351_9505_594953ae1219
type: Species
is: SBO:0000252
is encoded by: hsa:111
initial concentration: NaN
constant: false
name: ADCY5
boundary condition: true
is: O95622
has only substance units: false
initial amount: NaN

metaR r1629
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110033#
type: Reaction

metaR ACCOAtr
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
type: Reaction
kinetic law: MODEL1310110033#
fast: false
name: acetyl-coa transport
modifier: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_fb242c86_f908_4a9e_a4f4_193887bff633
constant: false
is: SBO:0000252
is encoded by: hsa:6568
boundary condition: true
name: SLC17A1
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q14916

metaM hs deg4 l
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
initial concentration: 1.0
boundary condition: false
name: heparan sulfate, degradation product 4
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:16126
has only substance units: false

metaM 2mop m
name: 2-methyl-3-oxopropanoate
type: Species
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false
is: HMDB01172
boundary condition: false
initial concentration: 1.0
is: CHEBI:57700
is: SBO:0000247
initial amount: NaN

metaM man c
initial concentration: 1.0
boundary condition: false
is: C00159
initial amount: NaN
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
is: SBO:0000247
is: HMDB00169
has only substance units: false
is: CHEBI:16024
name: D-Mannose

metaR GGH 7DHFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
name: Gamma-glutamyl hydrolase (7DHF), extracellular

metaM HC01444 e
initial amount: NaN
is: CHEBI:15754
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
type: Species
has only substance units: false
initial concentration: 1.0
name: Galactosylglycerol

metaR r1628
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#

metaR TAGt
reactant: MODEL1310110033#
is described by: ECO:0000000
name: triacylglycerol transport
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110033#
type: Reaction
fast: false

metaR ST6GALNAC31
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (256435.1) or (30815.1) or (81849.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110033#
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
is described by: ECO:0000269
type: Reaction
product: MODEL1310110033#
reversible: false

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR q10h2tc
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
reversible: true
name: transport of ubiquinol into cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000134

metaM Rtotal3coa c
is: HMDB01448
initial amount: NaN
name: R total 3 Coenzyme A
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16189
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_35f95dde_9f91_4c67_8540_f05c80bfe792
has only substance units: false
is: Q9NRM0
type: Species
name: SLC2A9
is encoded by: hsa:56606
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_0fb1c5de_d2d0_4669_aaff_f3dada1f788a
is: P27815
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: PDE4A
is encoded by: hsa:5141
type: Species
initial amount: NaN

metaR 4ABUTtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
name: 4-aminobutanoate mitochondrial transport via diffusion
is: SBO:0000185
reactant: MODEL1310110033#

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaR r1627
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1378
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
type: Reaction
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR SO4CLtex2
fast: false
is described by: ECO:0000304
reversible: false
name: sulfate transport via chloride countertransport (2:1)
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

metaR HAS2
is version of: http://identifiers.org/ec-code/2.4.1.212
fast: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
name: hyaluronan synthase
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_ffb4204e_4f24_451e_92bc_61099576841a
is: Q53HE2
name: TPI1
is encoded by: hsa:7167
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_07289c16_0ff5_4cc3_916e_5c9a74cb4cad
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P57103
name: SLC8A3
has only substance units: false
boundary condition: true
is encoded by: hsa:6547
initial concentration: NaN

metaR r0998
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110033#
name: Facilitated diffusion
kinetic law: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
reversible: true
type: Reaction
fast: false

metaR r1377
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110033#_599acb4e_fd17_43b1_94b1_faaedce34861
is encoded by: hsa:4967
constant: false
is: B4E3E9
name: OGDH
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR r0570
fast: false
type: Reaction
reversible: true
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
reactant: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.3.2
is described by: ECO:0000000
kinetic law: MODEL1310110033#

metaM hexdicoa x
type: Species
constant: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: SBO:0000247
name: hexadecanedioylcoa
initial concentration: 1.0
is: C14143
is: HMDB04047
boundary condition: false
has only substance units: false
initial amount: NaN

metaR DM gpi sig er
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR DALAt2r
reversible: true
modifier: MODEL1310110033#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: D-alanine transport via proton symport
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_8c00c6f8_f79c_4b72_9721_c3f355e00290
is: Q96KN2
name: CNDP1
initial amount: NaN
constant: false
is encoded by: hsa:84735
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM oaa m
name: Oxaloacetate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
type: Species
has only substance units: false
is: CHEBI:16452
is: C00036
is: HMDB00223
is: SBO:0000247
constant: false
initial amount: NaN

metaR r1626
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110033#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 4mlacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: SBO:0000247
name: 4-maleylacetoacetate
initial amount: NaN
is: CHEBI:17105
is: HMDB02052
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_244bd449_a323_4144_bb26_f1c0f2293a02
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:2584
boundary condition: true
name: GALK1
initial amount: NaN
is: P51570

metaR DUTPDPn
is version of: http://identifiers.org/ec-code/3.6.1.23
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
is: SBO:0000176
reversible: false
name: dUTP diphosphatase, nuclear
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#

metaR RE2625C
reversible: true
reactant: MODEL1310110033#
is: SBO:0000176
name: RE2625
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
fast: false

metaR r0575
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
fast: false
reversible: true
reactant: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000
type: Reaction

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_d4ba3cac_2658_4186_8bcf_5288ad98ba3c
is: Q2TU34
initial concentration: NaN
is encoded by: hsa:2203
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: FBP1

http://identifiers.org/biomodels.db/MODEL1310110033#_4ec8d3ec_d490_4484_a3a8_f0675744ac94
name: AK2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:204
is: P54819
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaR ACCOAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110033#
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaM CE2421 m
boundary condition: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
type: Species
initial concentration: 1.0
is: CHEBI:30623
has only substance units: false
constant: false
is: HMDB02329
initial amount: NaN
is: SBO:0000247
name: (3S)-3-hydroxylinoleoyl-CoA

metaM 3mgcoa m
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: trans-3-methylglutaconyl-CoA(5-)
boundary condition: false
is: HMDB01057
is: SBO:0000247
has only substance units: false
is: CHEBI:57346
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231

http://identifiers.org/biomodels.db/MODEL1310110033#_97567df3_81c4_4a62_91a3_2bcf864ce648
boundary condition: true
is: Q4W5N8
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:51166
initial amount: NaN
name: AADAT

metaR ME2m
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.40
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.38
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: malic enzyme (NADP), mitochondrial
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF

metaM xol7ah c
constant: false
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
initial concentration: 1.0
is: CHEBI:2290
is: HMDB06892
initial amount: NaN
name: 7alpha-hydroxy-5beta-cholestan-3-one
type: Species
is: SBO:0000247
boundary condition: false

metaR ARTCOAL2
is described by: ECO:0000000
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
name: R group coenzyme a ligase
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: R group synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:HR fatty acid metabolism - R groups = acyl groups, Rtotal, Rtotal2, Rtotal3 correspond to three possible acyl groups added to glycerol Carbon stoichiometry normalized wrt C16 R1 - C16 groups R2 - essential FA + associated derivatives R3 - non-essential, dietary FA (C18) R4 - monounsaturated FA R5 -other (C26, C24) NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_24ee4fec_27de_43eb_b1bc_95cec508a3d8
name: NDUFB7
is encoded by: hsa:4713
is: P17568
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_c542a206_5ce3_4fc5_8886_04c79501c84c
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q5K4L6
has only substance units: false
is encoded by: hsa:11000
type: Species
initial amount: NaN
name: SLC27A3
boundary condition: true

metaR MI145PK
is: SBO:0000176
name: inositol-1,4,5-trisphosphate 3-kinase
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.127
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_5f759e98_086f_441c_ab15_03f75a90f83a
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000297
has part: Q7L2M7
name: PFKL:PFKP
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:5211

metaR ADRNt
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110033#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR r0129
modifier: MODEL1310110033#
fast: false
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110033#
reversible: true
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4

metaM apoC m
is: CHEBI:32551
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: HMDB00182
name: Apocarboxlase (no lys residue)

metaR r0573
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:438652 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
name: Cholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_a7d990ce_702a_47c4_8b34_ead29a07940e
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
boundary condition: true
initial amount: NaN
has part: B4DY56
has only substance units: false
constant: false
is encoded by: hsa:498
type: Species
initial concentration: NaN
is: SBO:0000297

metaM gal l
initial amount: NaN
is: HMDB00143
type: Species
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
has only substance units: false
boundary condition: false
is: CHEBI:12936
constant: false
name: D-galactose
initial concentration: 1.0

metaR r2079
reversible: true
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
fast: false

metaM ha pre1 e
constant: false
is: SBO:0000247
name: hyaluronan biosynthesis, precursor 1
initial amount: NaN
type: Species
is: CHEBI:16126
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR SUCOASm
product: MODEL1310110033#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110033#
type: Reaction
reversible: true
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000000
name: Succinate--CoA ligase (ADP-forming)
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
kinetic law: MODEL1310110033#

metaM alpam m
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB06239
name: S-aminomethyldihydrolipoamide
has only substance units: false
boundary condition: false

metaR BTND1
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
is described by: ECO:0000269
is: SBO:0000176
name: biotinidase (biotin)
type: Reaction
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_5bc1aee6_9c89_42cb_8002_66ea72d0eb1a
is: E7EPT3
is: SBO:0000252
is encoded by: hsa:501
initial concentration: NaN
type: Species
has only substance units: false
name: ALDH7A1
constant: false
initial amount: NaN
boundary condition: true

metaM c12dccoa x
is: HMDB04047
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
type: Species
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
name: dodecanedioylcoa
is: C14143
initial concentration: 1.0

metaM malcoa r
is: SBO:0000247
is: CHEBI:57384
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
name: malonyl-CoA(4-)
is: HMDB01175
constant: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial concentration: 1.0

metaM val L c
initial concentration: 1.0
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: HMDB00883
is: CHEBI:16414
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_4b6d59e4_f9c2_4f83_a313_9aadcac9b0a5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8309
has only substance units: false
is: Q99424
boundary condition: true
name: ACOX2
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6ee7a080_6187_4437_86c1_7de97a359386
is: SBO:0000252
constant: false
type: Species
name: B3GALNT1
boundary condition: true
has only substance units: false
initial amount: NaN
is: O75752
initial concentration: NaN
is encoded by: hsa:8706

http://identifiers.org/biomodels.db/MODEL1310110033#_0a04c216_45fa_4bf1_9326_469a314932f1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: Q15181
name: PPA1
initial amount: NaN
is encoded by: hsa:5464

metaR r1931
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110033#
reversible: false
is described by: ECO:0000000

metaR NDPK6m
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reversible: true
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#

metaM chsterol m
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00067
type: Species
name: cholesterol

metaM pail35p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57923
boundary condition: false
initial amount: NaN

metaR CRNCARtp
name: carnitine-acetylcarnitine carrier, peroxisomal
product: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110033#
type: Reaction

metaR NDPK6n
is described by: ECO:0000304
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#

metaR r0553
reversible: true
product: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000176
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM chsterol l
name: cholesterol
initial amount: NaN
is: HMDB00067
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16113
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_b082d1da_cb88_424c_8915_4d821d18d15a
has only substance units: false
is: P49327
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2194
initial concentration: NaN
name: FASN

metaR DGK2m
product: MODEL1310110033#
fast: false
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000176

metaR BACCL
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: biotin-[acetyl-CoA-carboxylase] ligase
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.3.4.10
is described by: ECO:0000269
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_a651d889_9ca8_4c79_9850_74f8ffecb7a4
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: P02794
is encoded by: hsa:2495
name: FTH1

http://identifiers.org/biomodels.db/MODEL1310110033#_8b9f42b7_3288_4114_a6fb_2a16918e44d9
has only substance units: false
constant: false
is encoded by: hsa:5372
is: SBO:0000252
is: A8K003
boundary condition: true
initial concentration: NaN
name: PMM1
initial amount: NaN
type: Species

metaM hexdicoa r
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: SBO:0000247
is: C08260
has only substance units: false
is: HMDB00672
constant: false
type: Species
name: hexadecanedioylcoa
initial amount: NaN

metaM andrstrn r
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16032
is: HMDB00031
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
has only substance units: false
name: androsterone

metaR r0556
type: Reaction
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is described by: ECO:0000000
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176

metaR PNTEH
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
name: Hydrolase Class ( RXN R02973)
reversible: false
kinetic law: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.92
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#

metaR CHSTEROLt2
is described by: ECO:0000000
product: MODEL1310110033#
name: cholesterol intracellular transport
reversible: true
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185

metaR PE HSter
is: SBO:0000185
name: phosphatidylethanolamine scramblase
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
type: Reaction
reversible: true
fast: false

metaR r1930
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110033#
reversible: false
product: MODEL1310110033#
reactant: MODEL1310110033#

metaR NACHEX3ly
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR CHSTEROLt1
name: cholesterol intracellular transport
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
product: MODEL1310110033#

metaM pchol hs m
constant: false
initial amount: NaN
is: CHEBI:16110
name: Phosphatidylcholine
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_47e059e6_1080_4e39_b63d_0a405aab5d28
name: ME3
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is: Q6TCH8
is encoded by: hsa:10873
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_4793757c_793b_4beb_ba1d_7d3bf83f3246
boundary condition: true
name: SLC34A2
is encoded by: hsa:10568
type: Species
is: O95436
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaR PI4P3K
reversible: false
is: SBO:0000176
reactant: MODEL1310110033#
name: phosphatidylinositol 4-phosphate 3-kinase
modifier: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.154

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM ksi deg3 l
is: SBO:0000247
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: CHEBI:57312
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: keratan sulfate I, degradation product 3
boundary condition: false
is: HMDB01356

metaR ST3GAL21g
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.99.4
type: Reaction
is: SBO:0000176
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
is described by: ECO:0000269
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reversible: false
fast: false
product: MODEL1310110033#

metaR ACACT1x
type: Reaction
is: SBO:0000176
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000134
reversible: false
name: acetyl-CoA C-acetyltransferase, mitochondrial
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
kinetic law: MODEL1310110033#

metaR r2308
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaR GLNATB0tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Glutamine into the intestinal cells by ATB0 transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_a932a856_a06f_4036_9657_11d534f7de25
has only substance units: false
initial concentration: NaN
is: O15496
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: PLA2G10
boundary condition: true
is encoded by: hsa:8399

metaM q10h2 e
boundary condition: false
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: HMDB13111
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
name: Ubiquinol-10
initial concentration: 1.0
constant: false
initial amount: NaN

metaR S6TASE9ly
reversible: true
fast: false
reactant: MODEL1310110033#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110033#
type: Reaction

metaR r0558
type: Reaction
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
modifier: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_8c0f27ed_eced_4abb_b64a_5f56f2f004ae
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
name: ACAA2
is: P42765
initial concentration: NaN
is encoded by: hsa:10449

metaM dopasf c
is: HMDB06275
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
has only substance units: false
type: Species
constant: false
name: dopamine 3-O-sulfate
initial concentration: 1.0
is: CHEBI:37946

metaR SARDHm
kinetic law: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
fast: false
reversible: false
is: SBO:0000176
name: Sarcosine dehydrogenase (m)
type: Reaction
product: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.5.99.1

http://identifiers.org/biomodels.db/MODEL1310110033#_2d7b7f03_3cee_4a10_92f7_18fb12c6be63
boundary condition: true
is: SBO:0000252
is encoded by: hsa:BE966236
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: _BE966236_1_m
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_fd504dcd_6aa8_4bdd_99cd_acb7ab5bd9a2
initial amount: NaN
is: Q9BYZ2
is: SBO:0000252
name: LDHAL6B
is encoded by: hsa:92483
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaR EHGLATm
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000212
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
type: Reaction
product: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000176

metaR BILIRUBtr
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
product: MODEL1310110033#
name: lipid, flip-flop intracellular transport
fast: false
reversible: true

metaM CE0693 m
boundary condition: false
is: SBO:0000247
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
initial concentration: 1.0
is: HMDB11123
constant: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_9d3de30b_ba7c_4e0b_8d2a_30b0fc5a876d
name: HAGHL
type: Species
constant: false
is encoded by: hsa:84264
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q6PII5
is: SBO:0000252

metaM prostgd2 e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: CHEBI:57406
name: prostaglandin D2(1-)
type: Species
boundary condition: false
constant: false
is: HMDB01403
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_da506ca6_e94c_4c78_ae48_a07e3ce72cd0
is encoded by: hsa:4830
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
name: NME1
initial concentration: NaN
has only substance units: false

metaM ksi deg14 l
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 14
type: Species
is: CHEBI:12936
constant: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
initial concentration: 1.0
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110033#_927b6bfa_89a6_4c92_b54c_20508c4e9cbd
is: P23368
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: ME2
is encoded by: hsa:4200
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_a8930967_2640_4e4b_99dd_9e1083744583
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _AI620219_1_e
is encoded by: hsa:AI620219
has only substance units: false
type: Species

metaR NACHEX12ly
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110033#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110033#

metaM prostgi2 r
boundary condition: false
is: CHEBI:57403
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: prostaglandin I2(1-)
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

http://identifiers.org/biomodels.db/MODEL1310110033#_46efcab2_ff97_41ce_955c_16d6dadb10c1
is: P13686
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: ACP5
has only substance units: false
is encoded by: hsa:54

metaR RDH1a
kinetic law: MODEL1310110033#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.300
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.105
is: SBO:0000176
reactant: MODEL1310110033#
name: retinol dehydrogenase (all-trans,NADPH)
product: MODEL1310110033#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_ca8d2da1_f212_4ee1_b544_4970b4e6a63b
name: CA1
is: P00915
initial amount: NaN
type: Species
is encoded by: hsa:759
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_521f0234_ed9b_4551_9df0_6814f20bcb6a
type: Species
is encoded by: hsa:18
boundary condition: true
name: ABAT
has only substance units: false
is: P80404
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaM anth e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16567
has only substance units: false
is: HMDB01123
constant: false
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial amount: NaN
type: Species

metaR r1933
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110033#
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_862ff58c_153e_49f2_98bb_2ac60c0adc10
initial concentration: NaN
name: FUK
is encoded by: hsa:197258
is: Q8N0W3
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a971357c_9440_4595_a1ab_8f33530d7787
boundary condition: true
is encoded by: hsa:3423
name: IDS
constant: false
is: B4DGD7
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_85c3ed79_dd97_450d_bf79_82e4cf13bb75
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:47
type: Species
name: ACLY

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR r2309
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110033#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
reactant: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#

metaM dopasf e
is: HMDB06275
has only substance units: false
is: CHEBI:37946
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: SBO:0000247
type: Species
initial concentration: 1.0
name: dopamine 3-O-sulfate
constant: false
boundary condition: false
initial amount: NaN

metaR CITtam
type: Reaction
is: SBO:0000185
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
fast: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
name: citrate transport, mitochondrial
reactant: MODEL1310110033#
is described by: ECO:0000269

metaR CYTDK2m
name: cytidine kinase (ATP), mitochondrial
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_dadd0418_c944_4190_be08_c58dd43d94ef
is: SBO:0000252
name: ACOX1
type: Species
boundary condition: true
is: B4DK61
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51
has only substance units: false

metaM gq1b hs g
initial concentration: 1.0
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
name: GQ1b
is: CHEBI:7896
is: HMDB00220
is: C00249
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false

metaR RE3524R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
product: MODEL1310110033#
is described by: ECO:0000000
name: RE3524
fast: false
is: SBO:0000176
reactant: MODEL1310110033#
reversible: true
type: Reaction
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_76f14e95_2ccb_4bba_856d_0177f551df7f
is encoded by: hsa:19
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: ABCA1
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: O95477

metaM prostgd2 c
is: HMDB01403
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: prostaglandin D2(1-)
has only substance units: false
constant: false
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247

metaR r0559
is: SBO:0000176
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR r1686
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
name: Y+LAT2 Utilized transport
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_7592c575_7d37_4d27_8699_605b8c32c02b
type: Species
initial amount: NaN
is: Q96PE3
name: INPP4A
is: SBO:0000252
constant: false
is encoded by: hsa:3631
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM anth c
constant: false
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
name: anthranilate
is: SBO:0000247
is: HMDB01123
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:16567
initial concentration: 1.0

metaR r2091
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110033#
fast: false

metaR DAGK hs
is version of: http://identifiers.org/ec-code/2.7.1.107
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000269
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_4c6f90c5_9e79_4f6e_b3d9_1548d9d747dc
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:275
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: P48728
name: AMT

metaR UMPK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110033#
name: UMP kinase (CTP),nuclear
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_518a2b11_a8e5_4064_871a_a0e2794b77b6
boundary condition: true
name: SOAT1
is: B4DU95
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:6646
initial concentration: NaN
initial amount: NaN

metaR ST8SIA11
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.99.8
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_bbf30698_d6fc_4338_a92b_c22b0d0bfc64
is encoded by: hsa:124
is: P07327
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ADH1A
type: Species
has only substance units: false
constant: false
initial concentration: NaN

metaM tchola e
type: Species
is: HMDB00036
is: SBO:0000247
name: taurocholic acid
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0
initial concentration: 1.0
boundary condition: false

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM prostgi2 c
is: SBO:0000247
boundary condition: false
name: prostaglandin I2(1-)
is: CHEBI:57403
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335

metaM gq1b hs e
has only substance units: false
is: HMDB01397
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
type: Species
boundary condition: false
is: CHEBI:58115
constant: false
initial amount: NaN
name: GQ1b
is: SBO:0000247
initial concentration: 1.0

metaR EX glygly LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for glycylglycine
type: Reaction

metaR XOL7AH2tm
reactant: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
type: Reaction
kinetic law: MODEL1310110033#
reversible: true

metaR r2090
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true

metaM 3otdcoa x
is: HMDB03935
name: 3-Oxotetradecanoyl-CoA
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:28726
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false

metaM chsterol c
name: cholesterol
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00067
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
initial concentration: 1.0
is: CHEBI:16113

metaR DNDPt11m
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is described by: ECO:0000269
name: dADP transport via dGDP antiport
modifier: MODEL1310110033#

metaR ST8SIA12
is version of: http://identifiers.org/ec-code/2.4.99.8
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reversible: false
product: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
type: Reaction

metaR RE1903R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is: SBO:0000176
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#
reversible: true
name: RE1903
fast: false

metaM HC01377 m
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
name: S-(3-Methylbutanoyl)-dihydrolipoamide
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27462
type: Species
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_cf820ec5_dd8e_4a63_a418_8471b7a28cae
initial concentration: NaN
is: Q13057
constant: false
has only substance units: false
name: COASY
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:80347

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaM k c
is: CHEBI:29103
type: Species
is: C00238
boundary condition: false
constant: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
name: potassium
initial concentration: 1.0
has only substance units: false
is: HMDB00586
initial amount: NaN
is: SBO:0000247

metaM q10h2 c
is: SBO:0000247
name: Ubiquinol-10
type: Species
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

metaM tchola c
boundary condition: false
constant: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
is: HMDB00036
name: taurocholic acid
initial concentration: 1.0
is: CHEBI:36257
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM dudp m
is: HMDB01000
boundary condition: false
type: Species
is: CHEBI:60471
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP(3-)
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM frdp c
is: SBO:0000247
is: CHEBI:175763
boundary condition: false
is: C00448
initial amount: NaN
is: HMDB00961
initial concentration: 1.0
constant: false
type: Species
name: Farnesyl diphosphate
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_22285fc0_5797_45a9_8430_3b3c34b50b5b
is: SBO:0000252
is: P46721
has only substance units: false
is encoded by: hsa:6579
constant: false
name: SLCO1A2
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_c81319d6_1e77_40ca_98ac_d3d55767068a
initial concentration: NaN
is: O75610
has only substance units: false
name: LEFTY1
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:10637
is: SBO:0000252

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaM pchol hs e
name: Phosphatidylcholine
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: CHEBI:16110
type: Species

metaM dgchol e
is: HMDB00637
is: CHEBI:36252
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
initial amount: NaN
name: glycochenodeoxycholate
type: Species
initial concentration: 1.0
has only substance units: false

metaM gq1b hs c
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
boundary condition: false
type: Species
name: GQ1b
constant: false
is: C00249
initial amount: NaN
is: HMDB00220
is: CHEBI:7896
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_67a89f90_1283_4c27_98cc_650d58a5dda2
is: F5H123
name: DYLX2
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:9856
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaM btamp m
has only substance units: false
is: SBO:0000247
is: CHEBI:3110
constant: false
type: Species
is: HMDB04220
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
name: Biotinyl-5'-AMP
boundary condition: false

metaM hestratriol r
constant: false
boundary condition: false
is: HMDB05896
is: SBO:0000247
initial amount: NaN
name: 4,17 dihydroxy estradiol
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1

metaM chsterol e
initial concentration: 1.0
boundary condition: false
name: cholesterol
initial amount: NaN
is: SBO:0000247
is: HMDB00067
constant: false
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
type: Species
is: CHEBI:16113

metaM prostgi2 e
is: CHEBI:57403
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: SBO:0000247
is: HMDB01335
initial amount: NaN
boundary condition: false
name: prostaglandin I2(1-)
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_3fcbae80_5a33_4aec_9952_1b3170405a7c
name: PPA2
is: Q9H2U2
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:27068
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM dudp n
is: CHEBI:60471
constant: false
is: HMDB01000
has only substance units: false
is: SBO:0000247
name: dUDP(3-)
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_b88b54ef_5981_4477_87a1_c4a52f916ae2
initial concentration: NaN
is: SBO:0000252
name: ABAT
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:18
type: Species

metaM k e
is: SBO:0000247
constant: false
is: C00238
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
name: potassium
is: HMDB00586
initial amount: NaN
initial concentration: 1.0
is: CHEBI:29103
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_300fa260_a716_427a_9eee_39bc0cb62f83
is: SBO:0000252
is encoded by: hsa:94033
boundary condition: true
name: FTMT
type: Species
constant: false
initial amount: NaN
is: Q8N4E7
initial concentration: NaN
has only substance units: false

metaR RE1342C
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
product: MODEL1310110033#
type: Reaction
reversible: true
is: SBO:0000176
name: RE1342
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_b7c5ea84_9267_48d9_a467_7c42f04cb8ac
name: SLC24A2
is: SBO:0000252
is encoded by: hsa:25769
type: Species
constant: false
boundary condition: true
is: Q9UI40
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r0853
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
reactant: MODEL1310110033#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
type: Reaction

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR AKR1D2
kinetic law: MODEL1310110033#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is version of: http://identifiers.org/ec-code/1.3.1.3
modifier: MODEL1310110033#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_b88a3208_d229_4e91_b3cc_90f7237ab303
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM C02470 c
is: SBO:0000247
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5485
is: C02470
boundary condition: false
is: HMDB00881
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
name: Xanthurenic acid
initial amount: NaN
initial concentration: 1.0
type: Species

metaM gdpmann c
has only substance units: false
type: Species
constant: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
initial concentration: 1.0
boundary condition: false
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
is: CHEBI:57527
is: HMDB01163
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_20fc89d8_00fb_4ea7_b478_56baf0b5f682
is: Q9BYG0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: B3GNT5
constant: false
is encoded by: hsa:84002

metaM ksii core2 deg5 l
has only substance units: false
is: CHEBI:12936
notes: FORMULA: C50H82N4O38SX CHARGE: -1
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 5
is: HMDB00143
constant: false
is: SBO:0000247
type: Species

metaM pchol hs c
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16110
name: Phosphatidylcholine
has only substance units: false

metaR SADT
modifier: MODEL1310110033#
fast: false
is: SBO:0000176
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_d938745b_e75b_4896_80b7_10720272eba0
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: ATP5J2
boundary condition: true
has only substance units: false
is encoded by: hsa:9551
is: Q6IBB3
type: Species

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR r1683
modifier: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110033#_478b7df9_52b1_4d23_b4db_deadbd653859
is: SBO:0000252
name: SGPP1
initial amount: NaN
is encoded by: hsa:81537
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: Q9BX95

metaR r0016
name: Fe(II):oxygen oxidoreductase Porphyrin and chlorophyll metabolism EC:1.16.3.1
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.16.3.1
type: Reaction
notes: GENE_ASSOCIATION: (1356.1) or (2495.1) or (2509.1) or (94033.1) or (84343.1) SUBSYSTEM: Miscellaneous EC Number: 1.16.3.1 Confidence Level: 0 AUTHORS: PMID:16405854,PMID:2154449,PMID:9162052,PMID:9722559 NOTES:
is described by: ECO:0000000
is: SBO:0000176

metaM gd1b hs g
boundary condition: false
notes: FORMULA: C66H111N4O38FULLRCO CHARGE: -2
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: GD1b
constant: false
initial amount: NaN
is: CHEBI:28648
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_1b45f02f_0375_4248_93fc_ce597a06cfb7
name: PIK3R5
boundary condition: true
is: Q8WYR1
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:23533

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR r1640
reversible: true
reactant: MODEL1310110033#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM chol n
name: choline
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00097
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_7ab0de51_9b3a_48f4_8a14_1665023e26e2
boundary condition: true
is: P59796
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:257202
type: Species
name: GPX6

http://identifiers.org/biomodels.db/MODEL1310110033#_d25e0401_87c8_4b18_b42b_5f62ac87e81b
is: P43005
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: SLC1A1
is: SBO:0000252
is encoded by: hsa:6505
type: Species

metaR r1684
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
product: MODEL1310110033#
fast: false
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaM val L e
name: L-valine
is: HMDB00883
is: CHEBI:16414
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM ksi deg11 l
boundary condition: false
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: HMDB00143
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: keratan sulfate I, degradation product 11
initial amount: NaN

metaR LTC4CP
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
product: MODEL1310110033#
fast: false
name: Leukotriene C4 carboxypeptidase
reversible: true
reactant: MODEL1310110033#

metaR KYNAKGAT
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.64
name: L-Kynurenine:2-oxoglutarate aminotransferase
reactant: MODEL1310110033#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.7
is: SBO:0000176
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB

metaR r1641
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM msa m
has only substance units: false
is: SBO:0000247
is: HMDB11111
initial amount: NaN
name: 3-oxopropanoate
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
is: CHEBI:33190

metaM chol m
type: Species
has only substance units: false
is: HMDB00097
is: CHEBI:15354
constant: false
initial amount: NaN
name: choline
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_3f150859_7f58_4527_9143_d664602126d0
constant: false
has only substance units: false
initial amount: NaN
name: PLA2G2F
type: Species
is: Q9BZM2
is encoded by: hsa:64600
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR NOt
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
name: NO transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
is described by: ECO:0000000
type: Reaction
fast: false

metaR CERT2rt
modifier: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110033#
name: ceramide transport protein
reactant: MODEL1310110033#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is described by: ECO:0000000

metaR NBAHH ir
fast: false
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
modifier: MODEL1310110033#
is described by: ECO:0000134
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.4.13.20
notes: GENE_ASSOCIATION: (84735.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES:NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human

http://identifiers.org/biomodels.db/MODEL1310110033#_ada37040_db2e_4c51_80d2_08be18f1f897
is encoded by: hsa:516
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: P05496
initial concentration: NaN
is: SBO:0000252
name: ATP5G1
constant: false

metaR r1631
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dpcoa e
is: C00882
is: SBO:0000247
initial concentration: 1.0
is: HMDB01373
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
initial amount: NaN
constant: false
boundary condition: false
name: Dephospho-CoA
has only substance units: false
type: Species

metaM frdp x
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
type: Species
is: SBO:0000247
constant: false
name: farnesyl pyrophosphate(3-)
boundary condition: false
is: HMDB00961
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR ILETAm
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
name: isoleucine transaminase, mitochondrial

metaR r2202
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110033#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#

metaR r0400
product: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.2.4.4
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110033#
type: Reaction

metaR ABTti
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
name: L-arabinitol transport via passive diffusion
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
is: SBO:0000185

metaR RE2626C
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
fast: false
type: Reaction
is described by: ECO:0000000
name: RE2626

metaR r2086
fast: false
product: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110033#

metaM glyc e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:17754
is: HMDB00131
is: C00116
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
name: Glycerol
type: Species

metaR SFGTH
is described by: ECO:0000269
name: S-Formylglutathione hydralase
modifier: MODEL1310110033#
reversible: true
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.12
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6ccbcb56_debc_42f0_a7d9_5dc21c8115b6
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110033#_b2d0870f_2637_4e9f_8259_436d3f720178
type: Species
initial concentration: NaN
has only substance units: false
is: P43004
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: SLC1A2
is encoded by: hsa:6506

http://identifiers.org/biomodels.db/MODEL1310110033#_b0fa4062_5023_4f77_9897_f1d020c67538
type: Species
initial amount: NaN
is: SBO:0000252
name: _AA664770_1_m
boundary condition: true
is encoded by: hsa:AA664770
initial concentration: NaN
has only substance units: false
constant: false

metaR r0009
fast: false
modifier: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.6.1.1

http://identifiers.org/biomodels.db/MODEL1310110033#_7a395131_d36b_4cf6_ad8d_d12d4a935017
is: SBO:0000252
has only substance units: false
constant: false
name: CA12
initial concentration: NaN
is encoded by: hsa:771
initial amount: NaN
boundary condition: true
type: Species

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR PYDXDH
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.3.1
type: Reaction
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
is described by: ECO:0000269
name: pyridoxal dehydrogenase
fast: false
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_793bf688_858a_4e6e_ad93_cd9cc39ad844
is: P13929
constant: false
type: Species
name: ENO3
initial amount: NaN
is encoded by: hsa:2027
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_f2acc3d2_dc6d_4926_ab81_ccdcc2727cb5
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:221823
type: Species
is: SBO:0000252
name: PRPS1L1

metaR ADKd
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase (d form)
product: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110033#

metaR r2087
is described by: ECO:0000000
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
modifier: MODEL1310110033#

metaR r1630
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_8d2b809d_d154_49be_8469_bc62d8403198
type: Species
constant: false
is: SBO:0000252
name: FOLR1
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2348

metaM ppa m
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
has only substance units: false
is: CHEBI:17272
type: Species
constant: false
boundary condition: false
is: HMDB00237
initial concentration: 1.0
initial amount: NaN
name: propionate

metaM malttr e
constant: false
type: Species
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: HMDB01262
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27931
is: C01835
name: maltotriose
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_9f2f350e_270d_4379_92d7_462c0e71990a
constant: false
initial amount: NaN
is encoded by: hsa:5320
type: Species
has only substance units: false
is: P14555
boundary condition: true
name: PLA2G2A
is: SBO:0000252
initial concentration: NaN

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR VLCSr
kinetic law: MODEL1310110033#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
name: Very-long-chain-fatty-acid-CoA ligase
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
reversible: false

metaR r1633
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110033#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dpcoa c
is: C00882
initial concentration: 1.0
name: Dephospho-CoA
has only substance units: false
boundary condition: false
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57328

http://identifiers.org/biomodels.db/MODEL1310110033#_e8e55336_a63b_4437_89d6_a1b02ed892ea
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: O14556
has only substance units: false
type: Species
name: GAPDHS
boundary condition: true
is encoded by: hsa:26330

metaR FAOXC121C10x
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaM malcoa c
is: HMDB01175
name: Malonyl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
type: Species
is: CHEBI:57384
is: C00083
constant: false

metaR r2084
is described by: ECO:0000000
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110033#
is: SBO:0000185
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
reversible: true

metaR r1632
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_449e577c_9e42_4d57_b2d8_566bca244ff7
name: GALNT5
is: A5PKZ1
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:11227

metaM hs deg5 l
constant: false
is: HMDB00158
is: SBO:0000247
name: heparan sulfate, degradation product 5
initial concentration: 1.0
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
is: CHEBI:17895
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species

metaR r2085
product: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
fast: false
type: Reaction

metaM L2aadp c
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
initial concentration: 1.0
is: CHEBI:58672
has only substance units: false
name: L-2-aminoadipate(1-)
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species

metaR r2310
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
reversible: true
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_88b218e8_7a86_4009_93b1_ff450357dc7f
has only substance units: false
name: PLCH2
is encoded by: hsa:9651
initial amount: NaN
is: SBO:0000252
is: O75038
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaR r1635
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#

metaM 5fthf m
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
has only substance units: false
is: HMDB01562
is: CHEBI:57457
name: 5-formyltetrahydrofolate(2-)
type: Species

metaM chol c
boundary condition: false
constant: false
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: SBO:0000247
name: Choline
is: C00114
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:15354

metaR r2082
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000000

metaM dgchol c
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
name: glycochenodeoxycholate
has only substance units: false
constant: false
is: HMDB00637
initial amount: NaN
is: CHEBI:36252

metaM prpp c
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: HMDB00280
constant: false
initial concentration: 1.0
name: 5-Phospho-alpha-D-ribose 1-diphosphate
boundary condition: false
is: CHEBI:58017
has only substance units: false
is: C00119
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_585e4158_a441_46ab_a1ab_218de0ac0aa6
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10423
has only substance units: false
is: A8K3L7
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: CDIPT

metaM ala B e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: HMDB00056
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: beta-alanine
type: Species
is: CHEBI:16958

http://identifiers.org/biomodels.db/MODEL1310110033#_bd8bf143_4e00_408d_9e5f_d27786cdcde6
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P15309
initial concentration: NaN
is encoded by: hsa:55
initial amount: NaN
constant: false
type: Species
name: ACPP

metaR DGULND
reactant: MODEL1310110033#
fast: false
reversible: true
name: dehydro-L-gulonate decarboxylase
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000176

metaR DHCHOLESTANATEtm
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#
fast: false

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_e9275a8a_1921_4cea_af2f_f42a42dbf34a
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5295
type: Species
name: PIK3R1
initial amount: NaN
has only substance units: false
is: P27986
constant: false
boundary condition: true

metaR GALASE7ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
reversible: false

metaM pail4p hs c
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
is: CHEBI:58178
has only substance units: false
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial concentration: 1.0

metaM ksi deg9 l
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
type: Species
name: keratan sulfate I, degradation product 9
is: CHEBI:12936
constant: false
is: HMDB00143
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM lac D c
boundary condition: false
is: SBO:0000247
name: (R)-lactate
constant: false
is: CHEBI:16004
is: HMDB01311
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
type: Species
has only substance units: false

metaR r1634
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110033#

metaR r2083
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_05c54da0_beb5_4110_8a13_67fa3033fe93
constant: false
initial concentration: NaN
is: Q9Y2P5
boundary condition: true
initial amount: NaN
type: Species
name: SLC27A5
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10998

http://identifiers.org/biomodels.db/MODEL1310110033#_721c0988_50e8_47cd_b957_4f4cc7604e74
initial amount: NaN
name: _AI697028_1_e
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI697028
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_da1366fe_03d2_41f8_86a2_3bd8881a406b
is: Q8N3T1
name: GALNTL2
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:117248

http://identifiers.org/biomodels.db/MODEL1310110033#_c38ef473_3dc7_4569_af21_db9396d0c828
initial concentration: NaN
name: PIGL
boundary condition: true
type: Species
constant: false
is encoded by: hsa:9487
is: Q9Y2B2
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r1637
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM prpp e
is: CHEBI:58017
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Species
is: SBO:0000247
is: HMDB00280
has only substance units: false
constant: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r2080
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000185

metaR RE3241R
fast: false
is described by: ECO:0000000
modifier: MODEL1310110033#
name: RE3241
reversible: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000176
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaM chol e
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: Choline
constant: false
type: Species
has only substance units: false
is: HMDB00097
boundary condition: false
is: C00114
initial amount: NaN
is: SBO:0000247
is: CHEBI:15354

http://identifiers.org/biomodels.db/MODEL1310110033#_a59d4cf2_ba41_4194_a525_62c430ff0cb4
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2629
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P04062
name: GBA

http://identifiers.org/biomodels.db/MODEL1310110033#_80d085c3_0d65_4835_9ecd_9d6e1e3a3ebb
is: Q63HM1
initial concentration: NaN
is encoded by: hsa:125061
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: AFMID

http://identifiers.org/biomodels.db/MODEL1310110033#_05ef09e2_4f99_4197_a63f_652a3403fac2
is encoded by: hsa:8527
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: DGKD
constant: false

metaM glyc m
name: Glycerol
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17754
is: C00116
is: HMDB00131
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_31ab31ad_5158_4bef_af54_0a34886ff764
is: O95528
boundary condition: true
name: SLC2A10
is encoded by: hsa:81031
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaM lac D e
constant: false
has only substance units: false
boundary condition: false
is: HMDB01311
initial amount: NaN
is: CHEBI:16004
name: (R)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_fd206906_8725_4959_9905_46a25dbd24d2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4715
has only substance units: false
is: Q9Y6M9
name: NDUFB9
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR r1636
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110033#_1d3e41a5_f548_435a_8a96_0f306d7a0e73
is: SBO:0000252
name: AADAT
is: Q8N5Z0
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:51166
type: Species
boundary condition: true

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR r2081
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110033#_be31f8cb_cd76_4a70_a613_4def2fd72175
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q0VAA5
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:257068
name: PLCXD2

http://identifiers.org/biomodels.db/MODEL1310110033#_5f5fd26e_d2d7_4dcd_bc29_bae7df4b5c4b
is: B4DER4
constant: false
name: PIK3CB
is encoded by: hsa:5291
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_60ea1454_9304_4f07_9dfa_c507edcb6817
is: P23921
has only substance units: false
is encoded by: hsa:6240
name: RRM1
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM val L m
constant: false
initial concentration: 1.0
is: CHEBI:16414
is: HMDB00883
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
name: L-valine

metaM HC01412 m
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
type: Species
is: CHEBI:61405
boundary condition: false
constant: false
initial concentration: 1.0
name: trans-tetradec-2-enoyl-CoA(4-)
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_f85797ec_a17a_42da_b09d_b148af719e0b
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: TBXAS1
is: Q53F23
has only substance units: false
is encoded by: hsa:6916
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_42891c58_d20b_4a59_a4e2_ebb58de74fd5
initial concentration: NaN
name: ACADL
is: P28330
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:33

http://identifiers.org/biomodels.db/MODEL1310110033#_6e2e7116_c9ed_4d69_94e2_3e2d9f9a2274
name: PPCS
has only substance units: false
is: Q9HAB8
initial concentration: NaN
boundary condition: true
is encoded by: hsa:79717
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaR r0408
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reactant: MODEL1310110033#
fast: false
reversible: true
product: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.5
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110033#

metaM ppa c
constant: false
is: HMDB00237
initial concentration: 1.0
is: SBO:0000247
name: propionate
has only substance units: false
is: CHEBI:17272
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_27e5342a_3df2_4dc9_8bc9_0f23c3cddb41
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
name: PIGP
is encoded by: hsa:51227
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_ccbb5a7d_0ae9_42a2_a004_f3f4cd722f3d
type: Species
is: SBO:0000252
has only substance units: false
is: Q5SPY7
initial concentration: NaN
is encoded by: hsa:954
constant: false
initial amount: NaN
boundary condition: true
name: ENTPD2

metaM adn e
name: Adenosine
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:16335
is: HMDB00050
boundary condition: false
initial concentration: 1.0
is: C00212

metaM dpcoa m
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
name: 3'-dephospho-CoA(2-)
is: HMDB01373
is: CHEBI:57328

metaM 3snpyr m
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: 3-Sulfinopyruvate
boundary condition: false
is: HMDB02332
is: CHEBI:1665

metaM pail4p hs n
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: CHEBI:58178
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_217cddde_1e32_413c_ba17_26f4db72971b
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5137
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q8NB10
name: PDE1C

metaR r1639
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110033#

metaR r2315
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR CO2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: CO2 endoplasmic reticular transport via diffusion
fast: false
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
reversible: true

metaM HC02204 e
boundary condition: false
has only substance units: false
is: CHEBI:27624
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR r1638
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
reversible: true
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
modifier: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110033#_12d468d4_a7e4_4eb1_92c9_fca073bae17c
is encoded by: hsa:AA854479
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: _AA854479_1_m
type: Species
has only substance units: false
initial concentration: NaN

metaR THYOXt2
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false
product: MODEL1310110033#
name: T4 transport via facilitated diffusion
is: SBO:0000185

metaR r2316
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f614180d_78b8_4ecb_a8a5_1279e73c428a
name: SLC20A1
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: Q8WUM9
is encoded by: hsa:6574
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR AKR1D
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is described by: ECO:0000269
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.1.3
reversible: false
modifier: MODEL1310110033#
fast: false

metaM frdp r
initial amount: NaN
is: HMDB00961
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:175763
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
name: Farnesyl diphosphate
is: SBO:0000247
is: C00448

metaM ppa e
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false
is: SBO:0000247
name: propionate
initial amount: NaN
is: CHEBI:17272
is: HMDB00237

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_0f86d627_3564_43ce_8f70_908f93885fbb
is encoded by: hsa:1581
has only substance units: false
is: P22680
boundary condition: true
is: SBO:0000252
name: CYP7A1
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaM 3odcoa m
name: 3-Oxodecanoyl-CoA
is: HMDB03939
type: Species
is: CHEBI:28528
constant: false
initial amount: NaN
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_4b356424_96bd_466b_9158_720a011ad434
is encoded by: hsa:AA081045
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
name: _AA081045_1_c
type: Species

metaR FAOXC14C12x
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaR r2317
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM HC02204 c
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27624
name: prostaglandin-b1

metaR RE0908C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11861502,PMID:2765556,PMID:3988241,PMID:7263841,PMID:8767510 NOTES:
name: RE0908
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
reversible: true
fast: false

metaR GUAD
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.3
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000269
name: guanine deaminase
notes: GENE_ASSOCIATION: (9615.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.3 Confidence Level: 4 AUTHORS: PMID:10075721 NOTES:
type: Reaction
fast: false

metaR r0706
modifier: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.99.10
fast: false
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
is: SBO:0000176
reactant: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
reversible: false
type: Reaction

metaM HC02175 e
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:27689
name: caprate
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1

http://identifiers.org/biomodels.db/MODEL1310110033#_a68bfcea_cf50_4480_b07c_66e332425529
is: SBO:0000252
initial concentration: NaN
type: Species
name: ALDH3B2
is encoded by: hsa:222
is: P48448
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_a54a19f7_b7e4_4510_9c9b_67c24b61cb8e
initial concentration: NaN
name: LTA4H
type: Species
is: P09960
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4048
has only substance units: false
is: SBO:0000252

metaR r1527
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.1
kinetic law: MODEL1310110033#
reversible: false
type: Reaction
is: SBO:0000185

metaR R group phosphotase 1
fast: false
type: Reaction
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: R group phosphotase 1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false

metaR r0560
type: Reaction
fast: false
is: SBO:0000176
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: false

metaR r2318
reactant: MODEL1310110033#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ala B m
boundary condition: false
constant: false
has only substance units: false
is: HMDB00056
initial concentration: 1.0
name: beta-alanine
type: Species
is: SBO:0000247
is: CHEBI:16958
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN

metaM btamp c
name: Biotinyl-5'-AMP
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3110
is: HMDB04220

metaR CYTK14n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110033#
name: cytidylate kinase (dCMP,CTP),nuclear
kinetic law: MODEL1310110033#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110033#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_0b0512f5_25bc_4300_9028_6d8c0b01b3b4
constant: false
has only substance units: false
initial concentration: NaN
name: SCD
boundary condition: true
initial amount: NaN
is encoded by: hsa:6319
is: O00767
type: Species
is: SBO:0000252

metaR r2311
type: Reaction
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110033#

metaM biocyt e
type: Species
constant: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
name: Biocytin
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
has only substance units: false
is: C05552
is: HMDB03134
boundary condition: false
initial amount: NaN

metaM spmd c
is: CHEBI:57834
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: HMDB01257
initial amount: NaN
has only substance units: false
is: C00315
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_2099e2a3_caff_4aeb_b623_7f731a0abc9d
initial concentration: NaN
is: P06858
boundary condition: true
name: LPL
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:4023
is: SBO:0000252
type: Species

metaR EX 25hvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_9121d3d6_3421_4f77_8fc5_49236540ebde
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
is: SBO:0000297
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:518

metaM udpacgal c
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
is: CHEBI:57847
is: SBO:0000247
has only substance units: false
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_60c32b96_d90f_47fc_a7d6_6b10a4133c09
type: Species
is: SBO:0000252
name: _AA576959_1_c
has only substance units: false
is encoded by: hsa:AA576959
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

metaR HACD1m
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110033#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
fast: false

metaM hs deg11 l
name: heparan sulfate, degradation product 11
is: HMDB00868
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
has only substance units: false
is: CHEBI:57737
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_65714073_2aeb_4694_bd76_7ed5e9ede3ac
constant: false
initial amount: NaN
name: ALPPL2
is encoded by: hsa:251
is: SBO:0000252
type: Species
initial concentration: NaN
is: P10696
boundary condition: true
has only substance units: false

metaM HC02175 c
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
name: caprate
is: CHEBI:27689
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_fb427e7a_906e_40ae_b345_c6b1eccf668c
constant: false
is encoded by: hsa:5277
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PIGA
type: Species
is: SBO:0000252
initial amount: NaN

metaR r2312
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
reversible: true
product: MODEL1310110033#

metaM dhlam m
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:17694
initial amount: NaN
constant: false
name: dihydrolipoamide
is: SBO:0000247
is: HMDB00985

metaM q10h2 m
name: Ubiquinol-10
type: Species
is: HMDB13111
has only substance units: false
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247

metaM 3otdcoa m
initial amount: NaN
constant: false
initial concentration: 1.0
name: 3-Oxotetradecanoyl-CoA
is: SBO:0000247
type: Species
is: CHEBI:28726
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
has only substance units: false
boundary condition: false
is: HMDB03935

metaM zymstnl r
boundary condition: false
initial amount: NaN
is: CHEBI:16608
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
type: Species
name: 5alpha-cholest-8-en-3beta-ol
has only substance units: false
is: HMDB06841

metaR CITt4 2
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: citrate transport via sodium symport
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
fast: false
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_c9c7b2bf_1a91_46a2_9b78_3d1e14a0a613
initial concentration: NaN
constant: false
is encoded by: hsa:AF116616
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AF116616_1_m
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_d66b648c_63bd_47c2_a45c_8995377087b3
has only substance units: false
initial amount: NaN
is: Q16774
initial concentration: NaN
boundary condition: true
name: GUK1
constant: false
is encoded by: hsa:2987
is: SBO:0000252
type: Species

metaM Rtotal2coa c
has only substance units: false
constant: false
is: C00055
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: CHEBI:60377
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00095
is: SBO:0000247
boundary condition: false
name: R total 2 coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110033#_40f77bdf_feeb_425d_bef4_be879895de6f
has part: O15269
is encoded by: hsa:9517
has part: O15270
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SPTLC1:SPTLC2
type: Species
is encoded by: hsa:10558
constant: false
is: SBO:0000297
has only substance units: false

metaR r2088
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_a0e67e94_af4d_4e52_9f82_282d7d12f05b
is: P04818
constant: false
boundary condition: true
name: TYMS
is encoded by: hsa:7298
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM biocyt c
initial amount: NaN
is: SBO:0000247
is: C05552
initial concentration: 1.0
name: Biocytin
boundary condition: false
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
has only substance units: false
type: Species
constant: false

metaM glyc c
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false
is: CHEBI:17754
is: C00116
initial concentration: 1.0
initial amount: NaN
name: Glycerol
is: HMDB00131
constant: false

metaR r2200
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
reversible: true

metaR r2313
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR SERGLYexR
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
modifier: MODEL1310110033#
reversible: true
name: L-Serine/Glycine reversible exchange
type: Reaction
is: SBO:0000185

metaM spmd e
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: SBO:0000247
constant: false
is: HMDB01257
initial amount: NaN
initial concentration: 1.0
type: Species
name: Spermidine
is: C00315
boundary condition: false
has only substance units: false
is: CHEBI:57834

metaR r0119
reversible: false
type: Reaction
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/5.1.3.14
fast: false
reactant: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaR r0407
product: MODEL1310110033#
is described by: ECO:0000000
reversible: true
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
modifier: MODEL1310110033#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.4.3.5

metaR DNDPt26m
reactant: MODEL1310110033#
fast: false
name: dCDP transport via dUDP antiport
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185

metaR ACACT1r
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
name: acetyl-CoA C-acetyltransferase
kinetic law: MODEL1310110033#

metaR r2089
kinetic law: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2201
modifier: MODEL1310110033#
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110033#
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110033#

metaR GALt4
kinetic law: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110033#
name: galactose transport via sodium symport
reactant: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110033#_c383342c_6c02_4e5c_ac24_2e1ea30d7f87
has only substance units: false
initial amount: NaN
is encoded by: hsa:23530
boundary condition: true
initial concentration: NaN
name: NNT
constant: false
is: Q13423
type: Species
is: SBO:0000252

metaR r2314
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR S6TASE25ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_75533867_4c69_433b_976f_fe1a90cf2853
boundary condition: true
is: P30838
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: ALDH3A1
is encoded by: hsa:218

metaM pd3 c
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Previtamin D3
initial concentration: 1.0
is: HMDB06500
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
constant: false
has only substance units: false

metaR ATPtx
is: SBO:0000185
type: Reaction
name: ATP transporter, peroxisomal
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true

metaM cspg a l
initial concentration: 1.0
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: SBO:0000247
is: HMDB02183
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:36005
initial amount: NaN
notes: FORMULA: C45H66N2O45S3X CHARGE: -5

metaR r0714
type: Reaction
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_b728562a_a709_4b6a_8265_bb45b2450fe6
boundary condition: true
name: PDE4C
type: Species
is: SBO:0000252
is: Q7KYS4
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5143
constant: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_7a7d6dba_34fe_4f18_903f_7f7bab5a9904
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM mag hs c
is: CHEBI:16987
constant: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB12130
type: Species
is: SBO:0000247
name: monoacylglycerol 2
boundary condition: false

metaR ADNt
reversible: true
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
name: adenosine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

metaM ksi deg40 l
notes: FORMULA: C40H68N2O31 CHARGE: 0
constant: false
boundary condition: false
type: Species
is: HMDB00143
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
name: keratan sulfate I, degradation product 40

metaR ACACT10m
name: acetyl-CoA C-acetyltransferase, mitochondrial
is: SBO:0000176
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reactant: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction

metaR MERCPLACCYSt
type: Reaction
fast: false
reversible: false
is: SBO:0000185
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_89fd7a05_53c1_40bd_8432_9ed4b66a3f3a
has only substance units: false
constant: false
type: Species
name: _AA021081_1_r
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA021081
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_3ed65f44_ff62_4563_9465_60a832c0d586
initial concentration: NaN
name: SULT1A1
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:6817
initial amount: NaN
constant: false

metaR BILDGLCURt
product: MODEL1310110033#
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
fast: false
is described by: ECO:0000269

metaR FUCtly
fast: false
type: Reaction
name: L-fucose efflux from lysosome
reversible: false
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
kinetic law: MODEL1310110033#
is: SBO:0000185

metaM air c
constant: false
is: HMDB01235
type: Species
is: CHEBI:58592
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C03373

metaR RE3270C
type: Reaction
name: RE3270
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#

metaM h2o2 e
initial amount: NaN
is: SBO:0000247
name: hydrogen peroxide
boundary condition: false
constant: false
is: HMDB03125
has only substance units: false
type: Species
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
is: CHEBI:16240

metaR RE2541E
modifier: MODEL1310110033#
name: RE2541
is version of: http://identifiers.org/ec-code/3.2.1.31
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110033#
reversible: true
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:

metaM mag hs e
name: monoacylglycerol 2
is: SBO:0000247
is: CHEBI:60479
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r0157
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.2
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
reversible: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
fast: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110033#

metaM camp c
initial concentration: 1.0
name: 3',5'-cyclic AMP(1-)
type: Species
is: HMDB00058
is: CHEBI:58165
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
boundary condition: false
constant: false
is: SBO:0000247

metaR NMNtn
kinetic law: MODEL1310110033#
reversible: true
type: Reaction
name: NMN transport, nuclear trhough pore
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reactant: MODEL1310110033#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR DCTPtn
reactant: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dCTP diffusion in nucleus
type: Reaction
is: SBO:0000185
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_a0c96b50_6ad0_4ac5_b26b_efb9fb11782b
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: FOLR3
initial concentration: NaN
type: Species
constant: false
is: Q05C14
is encoded by: hsa:2352
has only substance units: false

metaR r2319
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

metaM gtp n
is: SBO:0000247
boundary condition: false
is: HMDB01273
initial amount: NaN
is: CHEBI:37565
name: GTP(4-)
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_be396faf_556e_44e1_ab7d_5cbbe5a2bc18
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: DHCR24
is: Q15392
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1718

metaM h2o2 m
initial concentration: 1.0
is: SBO:0000247
constant: false
name: Hydrogen peroxide
initial amount: NaN
type: Species
is: C00027
boundary condition: false
has only substance units: false
is: CHEBI:16240
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaR HSD3B2r
reversible: false
product: MODEL1310110033#
name: 3 beta-hydroxysteroid dehydrogenase type 1
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.145
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11384872,PMID:14643063 NOTES:see PMID: 14643063 specific cofactors/etc have not yet been determined - largely inferred NJ
is described by: ECO:0000269

metaR H2Oter
type: Reaction
product: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reversible: true
kinetic law: MODEL1310110033#
name: H2O endoplasmic reticulum transport
is described by: ECO:0000000

metaR CSNAT3x
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
modifier: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
name: carnitine O-aceyltransferase, peroxisomal
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.7
product: MODEL1310110033#
is: SBO:0000176
type: Reaction
fast: false

metaR CITt4 4
product: MODEL1310110033#
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
fast: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#
name: citrate transport via sodium symport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_8db8db16_f57b_4a55_8255_91be749a7d91
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5294
is: P48736
name: PIK3CG
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_fbe404a4_5177_482f_8e7a_b22e1630c296
type: Species
name: SLC4A8
is encoded by: hsa:9498
boundary condition: true
has only substance units: false
is: E7EML0
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_6ca74a01_30dd_44d7_ad9c_c41408442133
constant: false
has only substance units: false
type: Species
is: Q96RV2
name: HAS3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:3038

http://identifiers.org/biomodels.db/MODEL1310110033#_674b6ef2_3fb8_40cb_b823_812f1df3b923
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: UAP1L1
is: Q3KQV9
is encoded by: hsa:91373
initial concentration: NaN
initial amount: NaN
type: Species

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM acnamp c
is: HMDB06268
constant: false
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
name: N-Acetylneuraminate 9-phosphate
has only substance units: false
is: CHEBI:27438
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

metaR PI4PLCn
fast: false
modifier: MODEL1310110033#
type: Reaction
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
is: SBO:0000176
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.4.11
is described by: ECO:0000269
reversible: false

metaR ACP1 FMN
name: acid phosphatase (FMN)
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: false
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
is: SBO:0000176

metaM HC00900 c
name: Methylmalonate
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: CHEBI:30860
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_c22c66dc_a588_4de6_823d_495b163ccaf2
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5139
is: Q14432
name: PDE3A
has only substance units: false

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_4f204207_100a_451f_86e8_f4d753094cc8
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:522
name: ATP5J
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_e237c1d2_67e4_42a0_b7f0_68203e12d62e
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:1178
is: C5HZ13
name: CLC
has only substance units: false
type: Species
is: SBO:0000252

metaR LYSOXp
name: L-lysine oxidase, peroxisomal
kinetic law: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#

metaM 4ppcys c
is: SBO:0000247
has only substance units: false
is: C04352
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
boundary condition: false
is: CHEBI:59458
constant: false
type: Species
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
initial amount: NaN
is: HMDB01117
initial concentration: 1.0

metaM HC01459 x
initial amount: NaN
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:27458

metaR CORE6GTg
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false

metaR GLUNm
reversible: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
name: glutaminase (mitochondrial)
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2744.1) or (27165.2) or (27165.1) SUBSYSTEM: Glutamate metabolism EC Number: 3.5.1.2 Confidence Level: 4 AUTHORS: PMID:10719215,PMID:12579526 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.2
fast: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_5a687d7a_65df_454e_8b30_cc086798d49f
is encoded by: hsa:6582
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: O15244
name: SLC22A2
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_76b65b44_15b5_4a99_b335_266c81406dc1
constant: false
is: P30084
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: ECHS1
is encoded by: hsa:1892

http://identifiers.org/biomodels.db/MODEL1310110033#_6a65731c_6203_4642_8ca6_87c2987e6248
name: DCTD
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: P32321
is encoded by: hsa:1635
is: SBO:0000252

metaM gtp m
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01273
initial concentration: 1.0
is: C00044
boundary condition: false
name: GTP
is: CHEBI:37565
constant: false
has only substance units: false

metaM m2mn l
has only substance units: false
boundary condition: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
initial concentration: 1.0
type: Species
is: HMDB06537
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_d0cb4b8a_da44_49cd_b209_a567b87c3240
name: ADH1B
constant: false
initial concentration: NaN
is: P00325
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:125

metaR r1691
modifier: MODEL1310110033#
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
product: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_a250c483_3fdb_44f0_ad39_59bd98399fdb
boundary condition: true
initial amount: NaN
has only substance units: false
is: P21589
constant: false
initial concentration: NaN
is encoded by: hsa:4907
is: SBO:0000252
name: NT5E
type: Species

metaR GLNtN1
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Glutamine transport (Na, H coupled)
type: Reaction
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000269
kinetic law: MODEL1310110033#

metaR GLCter
reversible: true
reactant: MODEL1310110033#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
name: glucose transport, endoplasmic reticulum
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
kinetic law: MODEL1310110033#

metaM 3odcoa x
is: HMDB03939
is: SBO:0000247
has only substance units: false
is: CHEBI:28528
initial amount: NaN
name: 3-Oxodecanoyl-CoA
constant: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_d6493d15_0715_4661_bc0a_7a6d2e896b67
name: ALG5
has only substance units: false
constant: false
type: Species
is encoded by: hsa:29880
boundary condition: true
initial amount: NaN
is: Q9Y673
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_fba4642c_19ca_4bbf_90b3_c083941efd31
name: OXCT1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5019
initial amount: NaN
type: Species
is: P55809
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_08b8b0e4_61c1_4d7f_9f89_e2b2351ceb14
boundary condition: true
name: LDHC
initial amount: NaN
is: SBO:0000252
is: P07864
has only substance units: false
is encoded by: hsa:3948
initial concentration: NaN
type: Species
constant: false

metaM 3pg c
is: http://identifiers.org/pubchem.compound/3497
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: 3-Phospho-D-glycerate
type: Species
is: CHEBI:58272
constant: false
boundary condition: false
is: HMDB00807
is: C00197

metaR r1652
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM 4ppcys m
has only substance units: false
type: Species
is: HMDB01117
boundary condition: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:59458
initial concentration: 1.0
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)

metaM 4nph c
name: 4-nitrophenolate
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57917
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01232

metaM 4h2oglt m
is: CHEBI:17742
name: 4-hydroxy-2-oxoglutarate(2-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02070
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2

metaR r1653
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_15c60914_8884_4cc9_af6d_3b80ca2e7986
is encoded by: hsa:2645
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: GCK
type: Species
is: SBO:0000252
is: Q53Y25

metaR HSD3A1r
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reversible: true
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaR ACGPID
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
name: N-acetylglucosaminylphosphatidylinositol deacetylase
type: Reaction
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.5.1.89
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110033#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_23086cfa_0d71_4ab6_acb1_240e85e85a82
constant: false
initial amount: NaN
is encoded by: hsa:1340
is: SBO:0000252
is: P14854
name: COX6B1
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_c9df54b5_d7a8_49e6_865a_4dcf196ad966
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: MTMR3
is encoded by: hsa:8897
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_ec728f17_67db_47ca_a731_505f8952fae3
initial amount: NaN
name: PRDX1
initial concentration: NaN
boundary condition: true
type: Species
is: Q06830
is: SBO:0000252
is encoded by: hsa:5052
has only substance units: false
constant: false

metaM ksi e
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00211
name: keratan sulfate I
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: CHEBI:17268
initial concentration: 1.0

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

metaR CYTK10
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: cytidylate kinase (CMP,dGTP)
fast: false
product: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

metaR r1650
fast: false
modifier: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM g3pc c
is: SBO:0000247
constant: false
is: CHEBI:16870
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00086
has only substance units: false
name: sn-Glycero-3-phosphocholine

metaM glyald m
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17378
name: D-glyceraldehyde
type: Species
is: HMDB01051
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577

metaM HC10852 r
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
name: palmitoleyl-CoA(4-)
is: CHEBI:61540
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_c6e2a54f_6cad_48dc_8bf2_3492fee98735
is: SBO:0000252
is encoded by: hsa:AI222095
name: _AI222095_1_m
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species

metaM cs e deg5 l
is: CHEBI:57737
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H47NO35S3 CHARGE: -4
constant: false
has only substance units: false
boundary condition: false
is: HMDB00868
type: Species
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5

metaR r0698
type: Reaction
fast: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.2.27
product: MODEL1310110033#
is: SBO:0000176
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
is described by: ECO:0000000
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110033#_70e1d783_8c28_4cfa_a3fa_d24feff54731
is encoded by: hsa:57665
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q9HBH5
type: Species
name: RDH14
initial concentration: NaN
constant: false
has only substance units: false

metaR r1651
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_8d062ed0_5aa8_4b67_b351_c0a4847f5944
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4724
type: Species
name: NDUFS4
is: SBO:0000252
has only substance units: false
is: O43181

metaM gtp e
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
type: Species
initial concentration: 1.0
name: GTP(4-)
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

metaR CYTK12
reactant: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
is described by: ECO:0000269
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dCTP)
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_3200bac6_b6c7_419a_98d5_86be63399d4e
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: NME2
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:4831
is: P22392

http://identifiers.org/biomodels.db/MODEL1310110033#_f771384f_439f_4f49_8fd6_4a9604789842
initial amount: NaN
is: Q99944
boundary condition: true
initial concentration: NaN
has only substance units: false
name: EGFL8
is: SBO:0000252
constant: false
is encoded by: hsa:80864
type: Species

metaR r0156
reversible: false
kinetic law: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
fast: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
modifier: MODEL1310110033#

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_83f6378c_b59d_4bff_bc62_0bfeb20fb41d
boundary condition: true
name: STS
is encoded by: hsa:412
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P08842
type: Species

metaM ksi l
has only substance units: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: CHEBI:57455
is: HMDB01354
is: C00445
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: keratan sulfate I
initial concentration: 1.0
type: Species
constant: false

metaR NDPK3m
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000254
fast: false
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
modifier: MODEL1310110033#

metaR CYTK11
type: Reaction
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110033#
product: MODEL1310110033#
name: cytidylate kinase (dCMP,dGTP)
reactant: MODEL1310110033#
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000176

metaM L2aadp m
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:58672
initial concentration: 1.0
name: L-2-aminoadipate(1-)
type: Species
constant: false
is: HMDB00510

http://identifiers.org/biomodels.db/MODEL1310110033#_e45e1956_b08e_472f_b8e1_54c450384eea
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5305
constant: false
initial amount: NaN
is: P48426
name: PIP4K2A

http://identifiers.org/biomodels.db/MODEL1310110033#_59209bf8_bf0d_4929_8a92_0a8221f3cef5
name: SLC2A11
is encoded by: hsa:66035
is: Q8WXF9
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaR r0002
is: SBO:0000185
name: Active transport
fast: false
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR GLUPRT
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
reversible: false
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.2.14
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
name: glutamine phosphoribosyldiphosphate amidotransferase
reactant: MODEL1310110033#
is: SBO:0000176

metaM pacald c
is: HMDB06236
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: phenylacetaldehyde
type: Species
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: SBO:0000247
is: CHEBI:16424

metaR r0822
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_dcda97b6_f5c1_41da_a30e_bafc0dadb8cd
is encoded by: hsa:3417
boundary condition: true
name: IDH1
constant: false
is: SBO:0000252
is: O75874
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaM h2o2 c
constant: false
is: CHEBI:16240
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
initial amount: NaN
is: HMDB03125

metaR NDPK3n
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reversible: true
product: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
reactant: MODEL1310110033#

metaR CYTK14
product: MODEL1310110033#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,UTP)
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110033#

metaM gtp c
constant: false
is: CHEBI:37565
is: SBO:0000247
is: HMDB01273
initial concentration: 1.0
type: Species
name: GTP
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: C00044

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR GK1
is version of: http://identifiers.org/ec-code/2.7.4.8
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
modifier: MODEL1310110033#
name: guanylate kinase (GMP:ATP)
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: true

metaR r0821
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110033#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
fast: false

metaM 4nph e
type: Species
boundary condition: false
is: CHEBI:57917
initial concentration: 1.0
is: SBO:0000247
is: HMDB01232
name: 4-nitrophenolate
initial amount: NaN
constant: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_79ad5953_98c6_42b5_b494_cbfbbd4b551e
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
boundary condition: true
is: SBO:0000297
is encoded by: hsa:513
type: Species
is encoded by: hsa:514

metaR LEUPHELAT2tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR CHOLt4
product: MODEL1310110033#
reactant: MODEL1310110033#
name: choline, sodium cotransport
is described by: ECO:0000269
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
kinetic law: MODEL1310110033#
type: Reaction
fast: false
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_21e72669_2ec0_4405_95c5_1ea4e37cd7c7
constant: false
has only substance units: false
name: CPT2
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: P23786
is encoded by: hsa:1376

metaR CYTK13
reversible: true
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110033#
modifier: MODEL1310110033#
name: cytidylate kinase (dCMP,dATP)
product: MODEL1310110033#
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction

metaM dcholcoa x
boundary condition: false
is: HMDB06292
initial concentration: 1.0
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
type: Species
is: CHEBI:28701
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_08825f6b_d840_4eaf_aae0_3716c09e65e8
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:2876
name: GPX1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_61cea827_a02e_4b23_827b_c8440bec16a5
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:8140
type: Species
name: SLC3A2:SLC7A5
has only substance units: false
is: SBO:0000297
has part: Q8IV97
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_231ea90a_85d5_40af_9aa9_e47206a0a28f
constant: false
initial amount: NaN
is encoded by: hsa:64078
type: Species
is: SBO:0000252
is: Q9HAS3
initial concentration: NaN
boundary condition: true
name: SLC28A3
has only substance units: false

metaM man6p c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
name: D-Mannose 6-phosphate
is: CHEBI:17369
constant: false
boundary condition: false
type: Species
is: HMDB01078
initial concentration: 1.0
has only substance units: false

metaR RE2649C
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
product: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
fast: false
name: RE2649
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#

metaR GALU
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reactant: MODEL1310110033#
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.7.9
name: UTP-glucose-1-phosphate uridylyltransferase

metaR SPHMDAc
kinetic law: MODEL1310110033#
reversible: false
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: sphingomyelin deacylase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12069827 NOTES:limited details on mechanism, localization, etc. See PMID: 12069827 NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_b95a9b6c_dc73_499d_b3f1_784cc446086a
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:113235
is: Q96NT5
name: SLC46A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_45c57392_9aa6_4d3f_9b63_7c03169a6271
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q13093
is: SBO:0000252
is encoded by: hsa:7941
type: Species
constant: false
name: PLA2G7
initial concentration: NaN

metaR r2092
is: SBO:0000185
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM C05279 m
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB11123
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247
is: CHEBI:28387
name: trans,cis-Lauro-2,6-dienoyl-CoA
initial amount: NaN
has only substance units: false

metaM glyald c
type: Species
is: SBO:0000247
is: C00577
constant: false
initial concentration: 1.0
is: CHEBI:17378
name: D-Glyceraldehyde
is: HMDB01051
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
boundary condition: false

metaR r1649
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CITL
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
product: MODEL1310110033#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
name: Citrate lyase
type: Reaction
is: SBO:0000176

metaM acngalgbside hs g
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
name: sialyl galactosylgloboside
has only substance units: false
constant: false
is: CHEBI:16523
type: Species
initial amount: NaN
is: HMDB03406
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_a0df8ee8_ebc3_450d_aa01_52fe9fc196e5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5052
name: PRDX1
initial amount: NaN
has only substance units: false

metaR r0591
type: Reaction
product: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true

metaR EHGLAT2m
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110033#
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
reactant: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
is: SBO:0000176
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_316bf0bf_eefe_4515_b4a4_3a3f53e80691
name: RPIA
constant: false
initial concentration: NaN
has only substance units: false
is: P49247
boundary condition: true
is encoded by: hsa:22934
initial amount: NaN
is: SBO:0000252
type: Species

metaM 3hpcoa m
boundary condition: false
constant: false
name: 3-hydroxypropanoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: SBO:0000247
is: HMDB06807
initial concentration: 1.0
has only substance units: false
is: CHEBI:58528
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_406d48b1_3f76_4e58_8e29_fbad2bc7df96
is: SBO:0000252
constant: false
is encoded by: hsa:3631
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: INPP4A
type: Species

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaR r2093
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110033#

metaR BTNDm
name: biotinidase (biotin), mitochondrial
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: false
is: SBO:0000176
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.5.1.12
fast: false
is described by: ECO:0000269
reactant: MODEL1310110033#
type: Reaction

metaR LYStip
fast: false
reversible: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
name: L-lysine transport, peroxisomal (irreversible)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_007aad7f_74cd_4ec1_8936_578f931b9254
is: SBO:0000252
has only substance units: false
boundary condition: true
name: EHHADH
is: Q9NY65
initial concentration: NaN
is encoded by: hsa:1962
type: Species
constant: false
initial amount: NaN

metaR r1648
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
reversible: true
fast: false

metaR PRFGS
reversible: false
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
name: phosphoribosylformylglycinamidine synthase
is version of: http://identifiers.org/ec-code/6.3.5.3
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#

metaR NDP3ex
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110033#
name: nucleoside-diphosphatase (GDP), extracellular
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_3ea0e5c8_7a7e_4374_9944_aaa3e596ff87
type: Species
is: P00374
name: DHFR
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1719

metaR r2094
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM dadp c
name: dADP
type: Species
is: HMDB01508
is: CHEBI:57667
is: SBO:0000247
boundary condition: false
is: C00206
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_498cfe6c_f887_4d46_afd6_81750a5300ad
constant: false
is encoded by: hsa:122481
type: Species
initial amount: NaN
boundary condition: true
name: AK7
has only substance units: false
is: Q96M32
initial concentration: NaN
is: SBO:0000252

metaR DGAT
is: SBO:0000176
fast: false
product: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.20
name: diacylglycerol acyltransferase
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000

metaR RE3242R
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
fast: false
is: SBO:0000176
name: RE3242
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#

metaR r1647
product: MODEL1310110033#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_2dc94df3_9ca5_4dbc_99b2_f3ffeb1a23d0
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q8NEM3
is: SBO:0000252
name: SLC16A7
is encoded by: hsa:9194
boundary condition: true
initial amount: NaN

metaR RE1525M
reversible: true
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110033#
name: RE1525

metaR RADH2
name: retinal dehydrogenase (NADPH)
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110033#_9b13f374_d78b_4052_b189_4d0621e6573a
name: SLC6A9
is encoded by: hsa:6536
is: B7Z3W8
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaM ksi deg36 l
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: SBO:0000247
is: CHEBI:12936
is: HMDB00143
name: keratan sulfate I, degradation product 36
type: Species
boundary condition: false

metaM lgnc c
boundary condition: false
constant: false
is: HMDB02003
name: lignocerate
type: Species
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:31014

metaR TYRt4
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
fast: false
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
reversible: false
product: MODEL1310110033#
name: L-tyrosine transport in via sodium symport
reactant: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110033#_30932c3d_a8d7_49e8_93dd_672f1d7568ae
is encoded by: hsa:3030
is: SBO:0000252
has only substance units: false
is: E9KL44
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: HADHA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_7c0f221c_0cb3_4543_9f59_f2586b06d1ba
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:AL525798
initial concentration: NaN
name: _AL525798_1_c
is: SBO:0000252

metaR B3GNT39g
fast: false
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110033#
reversible: false

metaR r2095
is described by: ECO:0000000
product: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_cca8230b_931a_4576_b081_0eed32e6c93b
is encoded by: hsa:2678
has only substance units: false
name: GGT1
type: Species
is: SBO:0000252
constant: false
is: P19440
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_6c0736eb_39fb_446c_8e60_80af23029439
has only substance units: false
is encoded by: hsa:F23536
boundary condition: true
constant: false
name: _F23536_1_m
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_5257da15_86a7_4f9b_bb2b_e78fe314f8a8
is: SBO:0000252
name: SLC8A3
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6547

metaR r1646
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110033#
product: MODEL1310110033#

metaR r0590
reactant: MODEL1310110033#
is: SBO:0000176
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is described by: ECO:0000000
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
type: Reaction
reversible: false

metaM ps hs e
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: phosphatidylserine
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:18303
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

metaM dcholcoa r
boundary condition: false
is: HMDB06292
initial concentration: 1.0
initial amount: NaN
constant: false
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
is: CHEBI:28701
has only substance units: false
type: Species

metaR CITRtm
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110033#
modifier: MODEL1310110033#
name: citrulline mitochondrial transport via proton antiport
kinetic law: MODEL1310110033#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110033#
reversible: true

metaR r2096
kinetic law: MODEL1310110033#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
reversible: true

metaM idour l
is: CHEBI:21338
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB02704
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
constant: false
name: L-iduronate

metaR r2321
reversible: true
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM sph1p c
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: HMDB01383
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
type: Species
is: CHEBI:57939
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_fae9dd41_e4df_4378_b7d1_9338119ad1a4
boundary condition: true
type: Species
is encoded by: hsa:3704
has only substance units: false
is: Q9BY32
initial amount: NaN
is: SBO:0000252
name: ITPA
initial concentration: NaN
constant: false

metaR r1645
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
modifier: MODEL1310110033#
type: Reaction
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_dc027619_9547_4c9b_9636_251145fdeb32
constant: false
is: Q6FGA0
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9167
has only substance units: false
type: Species
is: SBO:0000252
name: COX7A2L

metaR r2097
fast: false
is described by: ECO:0000000
product: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_aadd8db3_2292_4864_998d_93fbd5aa824b
has only substance units: false
type: Species
name: SLC33A1
is: O00400
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9197
constant: false
boundary condition: true

metaR XYLTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
name: Xylitol transport via passive diffusion
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
reversible: true

metaM lgnc e
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB02003
type: Species
name: lignocerate
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: SBO:0000247
is: CHEBI:31014

metaR r2322
reactant: MODEL1310110033#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_7b9d125b_c2b1_4c91_9aa3_4bc81c6dcde6
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: NOS1
is: B4DG68
is: SBO:0000252
is encoded by: hsa:4842
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_227b90d4_ac49_41ca_bf13_bbd7f8b1d19a
is: SBO:0000252
name: CHKA
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:1119
initial concentration: NaN
type: Species

metaR r1644
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaR PYDXPP
is version of: http://identifiers.org/ec-code/3.1.3.3
reversible: false
notes: GENE_ASSOCIATION: (57026.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:14522954,PMID:6380540 NOTES:
is described by: ECO:0000304
name: Pyridoxal 5-phosphate phosphatase
fast: false
type: Reaction
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#

metaM ps hs c
name: ps_hs[c]
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:18303
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_cef4fce3_6f79_47f0_839f_efcabe833b09
is encoded by: hsa:3635
type: Species
name: INPP5D
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: Q92835
is: SBO:0000252
boundary condition: true

metaR BTNDe
kinetic law: MODEL1310110033#
name: biotinidase (biotin), extracellular
type: Reaction
product: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
is version of: http://identifiers.org/ec-code/3.5.1.12
is described by: ECO:0000269
reversible: false
is: SBO:0000176

metaR r2098
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110033#
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_2432bd79_bd1e_4bec_94fe_0e191fe9cd0d
has only substance units: false
is: SBO:0000252
name: PLCH1
initial concentration: NaN
is: Q4KWH8
is encoded by: hsa:23007
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR GALASE4ly
is described by: ECO:0000000
modifier: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
type: Reaction
fast: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaM sph1p e
is: CHEBI:57939
is: HMDB01383
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
type: Species
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM prostgd2 r
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57406
is: SBO:0000247
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
has only substance units: false
boundary condition: false
type: Species
name: prostaglandin D2(1-)

metaM HC01414 x
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h10-11,18-20,24-26,30,41-42H,4-9,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b11-10+/t20-,24-,25-,26+,30-/m1/s1 EHMN_ABBREVIATION: C05275
is: CHEBI:61406
initial concentration: 1.0
name: trans-dec-2-enoyl-CoA(4-)
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN

metaR r1643
product: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_ab1685c8_6bc6_4597_aa95_42645ffa1461
has only substance units: false
is encoded by: hsa:6526
type: Species
constant: false
is: SBO:0000252
name: SLC5A3
initial concentration: NaN
is: P53794
initial amount: NaN
boundary condition: true

metaR r2320
reactant: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110033#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r2099
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR r0829
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.1.1.37
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

http://identifiers.org/biomodels.db/MODEL1310110033#_b81f3a41_4ecd_4102_ac9b_cbdc038f5c5b
constant: false
name: _AI024818_1_c
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI024818
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_140b98df_b9f3_4c30_a56e_2a9434d17a86
is: SBO:0000252
boundary condition: true
name: ATP5J
is encoded by: hsa:522
is: Q6IB54
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM 3hpp m
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:16510
type: Species
name: 3-hydroxypropionate
is: HMDB00700
is: SBO:0000247
has only substance units: false
constant: false

metaR r1642
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#

metaM itaccoa m
name: itaconyl-CoA(5-)
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB03377
initial amount: NaN
is: CHEBI:57381
is: SBO:0000247
boundary condition: false

metaR FAOXC16C14x
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)x
type: Reaction

metaR r2325
fast: false
product: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110033#

metaR RE0512M
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE0512
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_68cf83ff_5dca_48f3_ba33_3305030329e4
has only substance units: false
is encoded by: hsa:6528
is: SBO:0000252
is: Q92911
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: SLC5A5

metaR OCDCAtr
reactant: MODEL1310110033#
name: fatty acid transport via diffusion
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110033#
fast: false

metaM chsterol r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
is: CHEBI:16113
initial concentration: 1.0
is: HMDB00067
boundary condition: false
type: Species
constant: false
is: SBO:0000247
name: cholesterol
initial amount: NaN

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR RE2649M
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
name: RE2649
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton

http://identifiers.org/biomodels.db/MODEL1310110033#_7bf525ed_0718_41b8_88d3_388b97ae55ff
is encoded by: hsa:10991
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
name: SLC38A3
is: Q99624
has only substance units: false
is: SBO:0000252

metaM so3 m
type: Species
has only substance units: false
name: hydrogensulfite
is: SBO:0000247
boundary condition: false
is: CHEBI:17137
initial amount: NaN
is: HMDB00240
initial concentration: 1.0
constant: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094

metaR CYSO
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110033#
name: cysteine oxidase
is version of: http://identifiers.org/ec-code/1.13.11.20
type: Reaction
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
modifier: MODEL1310110033#

metaR r2326
product: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110033#
fast: false
reversible: true
type: Reaction

metaM thyox L e
name: L-thyroxine
initial amount: NaN
is: CHEBI:18332
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false
type: Species
is: HMDB00248
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_c8fd0451_e79c_43c8_ae33_1c799fab42eb
is: O75438
initial concentration: NaN
is: SBO:0000252
name: NDUFB1
is encoded by: hsa:4707
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR RE0383C
fast: false
reversible: true
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
name: RE0383

http://identifiers.org/biomodels.db/MODEL1310110033#_389509ca_c8b7_411d_909e_16d1ce277017
boundary condition: true
constant: false
initial amount: NaN
name: PIK3R1
type: Species
is: E7EX19
is encoded by: hsa:5295
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r2471
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
is: SBO:0000185
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_890cec82_57a0_44ed_a57e_41be467dccbb
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:R14373
has only substance units: false
initial concentration: NaN
name: _R14373_1_x

metaR r2323
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r0719
reversible: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
notes: GENE_ASSOCIATION: (6697.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.153
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_da805153_4db9_478f_a5da_fbbf5345045f
is: Q75T13
initial amount: NaN
is encoded by: hsa:80055
is: SBO:0000252
constant: false
name: PGAP1
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM pmtcoa c
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: C00154
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:3454
has only substance units: false
is: HMDB01338

metaM HC01180 c
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
is: CHEBI:58694
constant: false
name: D-tagatofuranose 1,6-bisphosphate(4-)
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM idour e
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
name: L-iduronate
is: CHEBI:21338
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB02704
is: SBO:0000247

metaR RBTt
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110033#
name: ribitol transport via passive diffusion
is described by: ECO:0000000

metaM thyox L c
initial amount: NaN
is: CHEBI:18332
type: Species
is: HMDB00248
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_5efbfa9b_942b_4e5c_be9d_5c8a074b90b5
name: _AA532636_1_m
has only substance units: false
is encoded by: hsa:AA532636
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR FAS160COA
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000176
product: MODEL1310110033#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110033#

metaR NACHEX19ly
modifier: MODEL1310110033#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110033#
is described by: ECO:0000000

metaR r2324
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_7dc68d85_708d_42a0_b9c1_9775680515b2
initial concentration: NaN
type: Species
has part: Q6I9V2
is encoded by: hsa:498
has part: P25705
initial amount: NaN
constant: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:509

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_e728861d_16cb_4784_8995_e7f7e3397148
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is: P33121
boundary condition: true
type: Species
is encoded by: hsa:2180
has only substance units: false
name: ACSL1

http://identifiers.org/biomodels.db/MODEL1310110033#_8c68a88d_95ea_45ff_9974_d1c52844cac0
is: Q9UHI7
name: SLC23A1
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9963

metaR G3PD2m
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.5.3
fast: false
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2820.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES:replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
product: MODEL1310110033#
is described by: ECO:0000304
reversible: false
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_fb9fac9f_a771_4e00_baa8_a8503b0923a5
initial amount: NaN
has only substance units: false
constant: false
name: _728637_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:728637
boundary condition: true
initial concentration: NaN

metaR r2329
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

metaM ksi deg18 l
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
is: SBO:0000247
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 18
has only substance units: false
is: HMDB00143
is: CHEBI:12936

metaM ksi deg25 l
is: CHEBI:57455
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
boundary condition: false
is: HMDB01354
constant: false
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 25

metaM 2maacoa m
type: Species
initial amount: NaN
has only substance units: false
name: 2-methylacetoacetyl-CoA(4-)
boundary condition: false
constant: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
is: HMDB01157
is: CHEBI:57335
is: SBO:0000247
initial concentration: 1.0

metaR r0717
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110033#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_4f3bbcb3_f605_40b8_b53e_2a64235b36da
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: HK2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3099
is: P52789
initial concentration: NaN

metaR r0596
is described by: ECO:0000000
modifier: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000176
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
fast: false

metaM idour c
is: CHEBI:21338
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
has only substance units: false
type: Species
name: L-iduronate
is: SBO:0000247
initial concentration: 1.0
is: HMDB02704
initial amount: NaN
constant: false
boundary condition: false

metaM lac L x
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:16651
name: (S)-lactate
type: Species
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
constant: false
is: HMDB00190

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_03a12dc0_03a5_4208_b4a6_1641a288954c
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:160851
has only substance units: false
name: DGKH
initial amount: NaN
type: Species
constant: false
is: A8K0I1

metaR MI1P Dtn
is described by: ECO:0000000
type: Reaction
name: inositol 1-phosphate nuclear transport (diffusion)
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_75c57919_8e88_4014_8f33_8d3f84c8b147
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: P06865
name: HEXA
has only substance units: false
type: Species
is encoded by: hsa:3073
initial concentration: NaN

metaR DNDPt40m
reversible: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110033#
product: MODEL1310110033#
name: dUTP transport via dADP antiport

metaR NMNATr
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.7.1
modifier: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
name: nicotinamide-nucleotide adenylyltransferase
is described by: ECO:0000269
type: Reaction

metaR SO4tl
reversible: true
is: SBO:0000185
name: Sulfate transport (lysosome)
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110033#

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM nadph c
has only substance units: false
is: C00005
type: Species
is: HMDB00221
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
constant: false
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

http://identifiers.org/biomodels.db/MODEL1310110033#_a70382cd_17aa_4b53_8a10_8c9c72aad65e
is encoded by: hsa:48
boundary condition: true
name: ACO1
constant: false
initial concentration: NaN
has only substance units: false
is: P21399
type: Species
initial amount: NaN
is: SBO:0000252

metaM hs deg15 l
is: CHEBI:16126
name: heparan sulfate, degradation product 15
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C49H71N2O57S5 CHARGE: -7

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR r0718
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.181
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
reversible: false
product: MODEL1310110033#

metaR r2327
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
fast: false

metaM gbside hs g
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:18259
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR BTNPLm
fast: false
reactant: MODEL1310110033#
reversible: false
is: SBO:0000176
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.10
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
modifier: MODEL1310110033#

metaR r0715
is version of: http://identifiers.org/ec-code/6.3.2.5
kinetic law: MODEL1310110033#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_3438338c_1863_475d_b89a_848842658c59
name: OGDH
is: Q02218
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:4967

metaR ATPtm
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
name: ADP/ATP transporter, mitochondrial
reversible: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_404ea50a_f617_4954_9f34_d1b314e15d20
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:6569
name: SLC34A1
is: Q7Z725
is: SBO:0000252
boundary condition: true

metaR r2328
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110033#_652bc92b_483d_482e_818b_11eec6085972
is: Q9NY65
initial concentration: NaN
is encoded by: hsa:1962
boundary condition: true
constant: false
name: EHHADH
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR r0594
fast: false
modifier: MODEL1310110033#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
type: Reaction
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176

metaR TYRCBOX
kinetic law: MODEL1310110033#
fast: false
reversible: false
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
name: L-Tyrosine carboxy-lyase
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110033#
reactant: MODEL1310110033#

metaM tdcoa c
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: HMDB01521
is: CHEBI:57385
boundary condition: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247

metaM gt1alpha hs g
name: GT1aalpha
constant: false
has only substance units: false
is: CHEBI:28058
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_9fcbedea_c743_4d59_b3ab_e3c9cec15ac0
constant: false
name: GLS2
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:27165
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_a24b5204_3543_43dd_8ebe_f19966847206
type: Species
constant: false
is: SBO:0000252
is: Q92569
name: PIK3R3
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8503
initial amount: NaN

metaR r0716
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#

metaR ATPtn
reversible: true
type: Reaction
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110033#
name: ATP diffusion in nucleus
is: SBO:0000185
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaR r0724
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110033#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110033#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.33
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_001f6b20_fb1d_4de3_b5eb_b05fb92973c2
constant: false
initial amount: NaN
initial concentration: NaN
name: FBP2
boundary condition: true
type: Species
is encoded by: hsa:8789
is: SBO:0000252
has only substance units: false
is: O00757

http://identifiers.org/biomodels.db/MODEL1310110033#_3b22522e_a0f0_44c2_9b2a_1a5b9dcc333e
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55089
is: SBO:0000252
boundary condition: true
is: Q969I6
constant: false
type: Species
name: SLC38A4

metaR ECOAH1m
reactant: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110033#
reversible: true
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaM lac L e
type: Species
name: (S)-lactate
is: HMDB00190
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
is: CHEBI:16651
initial concentration: 1.0

metaM dcacoa m
boundary condition: false
is: SBO:0000247
is: CHEBI:61430
type: Species
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
name: Decanoyl-CoA (n-C10:0CoA)
is: HMDB06404
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_fc6453e1_c229_4970_b9b5_ad81daea440a
has only substance units: false
is: P11169
initial concentration: NaN
name: SLC2A3
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6515
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_1db9c600_13f3_4d9a_95b2_b58007262e8b
is encoded by: hsa:6240
has part: P31350
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000297
boundary condition: true
constant: false
is encoded by: hsa:6241
name: RRM1:RRM2
has part: P23921
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_01a0fdd2_6955_47d3_af6a_d3caa4dab2fa
is: SBO:0000252
is: A8K3J4
initial amount: NaN
constant: false
has only substance units: false
name: CA14
initial concentration: NaN
is encoded by: hsa:23632
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_ed63fbaa_e620_4762_8775_4be4cc9082a3
is encoded by: hsa:29124
initial amount: NaN
name: LGALS13
has only substance units: false
is: Q9UHV8
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaR r0723
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: false
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
is: SBO:0000176

metaM pro L e
has only substance units: false
name: L-proline
initial amount: NaN
is: HMDB00162
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
boundary condition: false
is: CHEBI:17203

metaR r0145
reactant: MODEL1310110033#
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.8.3.1
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
modifier: MODEL1310110033#
is described by: ECO:0000000
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
is: SBO:0000176
fast: false
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_d6beff3f_ebd9_4f5d_826c_dedbf5ee821c
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3177
name: SLC29A2
has only substance units: false
is: Q14542
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_9314e34d_177a_4b14_8e83_e72bf387db73
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4832
has only substance units: false
type: Species
name: NME3
is: Q13232
initial amount: NaN

metaR NDPK4n
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000304
product: MODEL1310110033#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110033#
reversible: true

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM dcholcoa c
boundary condition: false
is: HMDB06292
constant: false
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
is: CHEBI:28701
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337

metaM C02528 r
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
type: Species
constant: false
has only substance units: false
is: CHEBI:36234
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: chenodeoxycholate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_8067e4c6_4b7a_4701_b64b_a7f872c36781
name: NT5C1B
has only substance units: false
is encoded by: hsa:93034
constant: false
is: B3KUK6
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR r0726
modifier: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_85e3e43d_3f9f_42e7_82e8_a1c59e54fcc8
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:FLJ44968
type: Species
constant: false
name: _FLJ44968_1_m
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_d3c3645b_eb08_4090_ab0d_011241576e95
type: Species
name: GALNT8
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:26290
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9NY28

metaM lac L c
constant: false
name: (S)-lactate
has only substance units: false
type: Species
boundary condition: false
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_9f572d57_6bd5_43e9_81d9_78ddec1a34b2
initial amount: NaN
name: FUCA1
initial concentration: NaN
constant: false
is: SBO:0000252
is: P04066
is encoded by: hsa:2517
has only substance units: false
boundary condition: true
type: Species

metaR r1957
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110033#
reversible: false
modifier: MODEL1310110033#
reactant: MODEL1310110033#

metaM cs e deg4 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
constant: false
notes: FORMULA: C31H46NO38S4 CHARGE: -5
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00127
is: SBO:0000247
type: Species
is: CHEBI:15748
initial concentration: 1.0

metaR GLCURtly
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
reactant: MODEL1310110033#
name: glucuronate transport into lysososme
modifier: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110033#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_3856e09e_cb8a_4665_89c6_814455f4f930
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:3295
is: SBO:0000252
boundary condition: true
is: E9PB82
has only substance units: false
initial concentration: NaN
name: HSD17B4

metaM accoa r
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
name: acetyl-CoA(4-)
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: CHEBI:57288

metaR ACACtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000185
name: acetoacetate intracellular transport unknown mechanism
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
reversible: true

metaR EX c6dc
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for adipoyl carnitine
type: Reaction

metaR ORETNtn
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
name: 4-oxo-retinoic acid transport, Nuclear
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
fast: false
is described by: ECO:0000000

metaR CRNt
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
is: SBO:0000185
name: L-carnitine reversible transport
type: Reaction
modifier: MODEL1310110033#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_11403abd_ade4_4a18_b8ef_9faa2589439a
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3032
boundary condition: true
name: HADHB
is: P55084

http://identifiers.org/biomodels.db/MODEL1310110033#_6da492fc_c48b_4029_89e5_46e5ad09f2ac
has only substance units: false
is encoded by: hsa:498
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: A8K092
name: ATP5A1
initial amount: NaN

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR r0578
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110033#
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.27
reactant: MODEL1310110033#
is described by: ECO:0000000
type: Reaction

metaM 5adtststerone e
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
is: HMDB02961
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:16330
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one

metaM xu5p D c
name: D-xylulose 5-phosphate(2-)
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57737
is: HMDB00868
initial concentration: 1.0

metaR r1381
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reactant: MODEL1310110033#
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:

metaR r0720
is: SBO:0000176
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000000

metaM 1pyr5c c
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01301
constant: false
is: C03912
is: CHEBI:15893
is: SBO:0000247
initial concentration: 1.0
name: 1-Pyrroline-5-carboxylate

metaR FRDPtcr
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
fast: false
reversible: true
reactant: MODEL1310110033#
type: Reaction
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_8dde71b4_5170_448c_8240_826d32b93fe6
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: Q76EJ3
boundary condition: true
name: SLC35D2
is encoded by: hsa:11046
type: Species
initial concentration: NaN

metaM cs b deg2 l
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
initial concentration: 1.0
notes: FORMULA: C37H54NO41S3 CHARGE: -5
is: HMDB01354
has only substance units: false
is: CHEBI:57455

metaM accoa x
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: CHEBI:57288
type: Species
is: C00024
is: HMDB01206
is: SBO:0000247
name: Acetyl-CoA
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_58eacfd4_1e9c_4dda_92f1_39be86e74146
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ACOT8
type: Species
boundary condition: true
is encoded by: hsa:10005
constant: false
is: SBO:0000252
is: O14734

metaR DM atp c
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110033#
type: Reaction
name: DM_atp(c)
reversible: false
fast: false

metaR ALDD2xm
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
kinetic law: MODEL1310110033#
reversible: false
is: SBO:0000176
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
reactant: MODEL1310110033#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction

metaR r0149
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaM ksii core4 deg1 l
name: keratan sulfate II (core 4-linked), degradation product 1
initial amount: NaN
boundary condition: false
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
initial concentration: 1.0
constant: false
type: Species
is: HMDB00868
has only substance units: false
is: CHEBI:57737
is: SBO:0000247

metaM ksi deg6 l
is: CHEBI:12936
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB00143
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
initial amount: NaN
name: keratan sulfate I, degradation product 6

http://identifiers.org/biomodels.db/MODEL1310110033#_c426cb31_f9b7_4a0f_89a3_8ece74a4b2ad
name: GMPPA
constant: false
is encoded by: hsa:29926
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q96IJ6
has only substance units: false
boundary condition: true

metaM c14dccoa x
name: tetradecanedioylcoa
is: HMDB04047
is: C14143
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_17d6bd42_8fba_4fa3_8662_d400b9d52e65
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55229
type: Species
constant: false
name: PANK4
is: Q9NVE7
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_44b01b3b_3d5a_4b0b_adc5_92cbb1ccb5af
is encoded by: hsa:6548
boundary condition: true
type: Species
constant: false
is: P19634
initial concentration: NaN
is: SBO:0000252
name: SLC9A1
has only substance units: false
initial amount: NaN

metaM pmtcoa m
name: Palmitoyl-CoA (n-C16:0CoA)
is: HMDB01338
is: SBO:0000247
type: Species
is: C00154
has only substance units: false
initial amount: NaN
is: CHEBI:57379
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154

metaR r0722
is: SBO:0000176
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.3.12
product: MODEL1310110033#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR PI45P5P
product: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
kinetic law: MODEL1310110033#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
fast: false
reactant: MODEL1310110033#

metaM hmgcoa c
type: Species
is: CHEBI:15467
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
has only substance units: false
is: HMDB01375

http://identifiers.org/biomodels.db/MODEL1310110033#_5a441a59_c8e3_448f_8db9_1c2c225f9359
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: Q5TEK5
is: SBO:0000252
is encoded by: hsa:5142
name: PDE4B

metaR SR5ARr
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
modifier: MODEL1310110033#
fast: false
reversible: false
kinetic law: MODEL1310110033#
is described by: ECO:0000134
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is: SBO:0000176
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.99.5

http://identifiers.org/biomodels.db/MODEL1310110033#_9a086c22_6c0b_4a53_816d_db85b23c2b3c
type: Species
boundary condition: true
is encoded by: hsa:9162
initial amount: NaN
is: O75912
constant: false
has only substance units: false
name: DGKI
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_653cea8a_18c3_47f0_884f_8584fba42276
name: LDHA
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: P00338
is encoded by: hsa:3939
initial concentration: NaN
is: SBO:0000252
type: Species

metaM Tn antigen l
initial concentration: 1.0
is: C04383
has only substance units: false
name: Tn antigen
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H14NO5X CHARGE: 0
type: Species

metaR r1380
is described by: ECO:0000000
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
is: SBO:0000176
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction

metaR r0579
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.13.11.19
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110033#
type: Reaction

metaM HC00342 c
name: cis-aconitate(3-)
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16383
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR RE3381E
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
fast: false
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
reactant: MODEL1310110033#
modifier: MODEL1310110033#
name: RE3381

metaR r0721
type: Reaction
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
reactant: MODEL1310110033#

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaM 2dr5p c
is: CHEBI:57651
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
is: HMDB01031
initial amount: NaN

metaR CTPtn
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110033#
name: CTP diffusion in nucleus
type: Reaction

metaM HC00718 c
boundary condition: false
is: SBO:0000247
name: N-methylethanolaminium phosphate(1-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
is: CHEBI:57781
type: Species
constant: false

metaR FE3MTP1
fast: false
notes: GENE_ASSOCIATION: (30061.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000134
reactant: MODEL1310110033#
name: transport of ferrous iron into blood
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_6d040449_2249_4134_9af1_2b7cdae5c958
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10606
boundary condition: true
name: PAICS
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: P22234

metaM mev R c
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: CHEBI:36464
is: SBO:0000247
has only substance units: false
name: (R)-mevalonate
is: HMDB00227
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_6b26467d_8f0c_4e68_8cd6_06593b341ca9
constant: false
has only substance units: false
is: SBO:0000252
name: _AI972237_1_c
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI972237
type: Species
initial concentration: NaN

metaR O2ter
kinetic law: MODEL1310110033#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
name: O2 transport, endoplasmic reticulum
product: MODEL1310110033#

metaM i c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:16382
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
initial amount: NaN
is: HMDB12238
name: iodide

metaR MI34PP
modifier: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.66
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
is: SBO:0000176
product: MODEL1310110033#
kinetic law: MODEL1310110033#
name: inositol-3,4-bisphosphate 4-phosphatase
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
reversible: false

metaR r1662
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_d8e5d810_9587_4902_9155_6e0928007134
type: Species
is encoded by: hsa:3795
initial amount: NaN
boundary condition: true
is: P50053
initial concentration: NaN
name: KHK
is: SBO:0000252
has only substance units: false
constant: false

metaM mercppyr c
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB01368
is: CHEBI:57678
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
initial amount: NaN
initial concentration: 1.0
name: 3-mercaptopyruvate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f8cc7fc6_0e0d_41b4_8129_b3e1cd7a0cdb
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: PLD2
is: O14939
constant: false
is encoded by: hsa:5338
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_f989de6d_96f2_479b_8619_07b6e49abe3c
is: Q969X2
boundary condition: true
name: ST6GALNAC6
initial concentration: NaN
is encoded by: hsa:30815
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species

metaR HSD3A2r
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
fast: false
modifier: MODEL1310110033#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_570d7618_5416_48f0_887b_3a8a7c35ddcd
is: SBO:0000252
boundary condition: true
name: DGUOK
is encoded by: hsa:1716
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false

metaM xol7aone m
type: Species
is: SBO:0000247
is: CHEBI:17899
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one

metaM dgpi prot hs r
has only substance units: false
boundary condition: false
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
initial amount: NaN
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
is: HMDB01311
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16004
type: Species
constant: false

metaM dcacoa c
is: HMDB06404
is: C05274
is: CHEBI:61430
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
constant: false
name: Decanoyl-CoA (n-C10:0CoA)
has only substance units: false
type: Species

metaR GNMT
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
is described by: ECO:0000269
name: glycine N-methyltransferase
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.20
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_36f04b34_03ba_45b1_b496_43afa38d8822
is: C9JFZ1
name: SYNJ1
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:8867

metaM HC00342 m
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16383
name: cis-aconitate(3-)
constant: false
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial concentration: 1.0
initial amount: NaN

metaR TSTSTERONEtr
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
name: testosterone intracellular transport
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true

metaR r0686
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
type: Reaction
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaR 34HPPOR
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.27
kinetic law: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000269
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110033#
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase

metaR HIStN1
fast: false
is: SBO:0000185
is described by: ECO:0000269
name: Histidine transport (Na, H coupled)
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_9fa6cf09_b9a1_4870_a581_dd4da80e558b
boundary condition: true
initial amount: NaN
is: P30837
constant: false
is encoded by: hsa:219
has only substance units: false
is: SBO:0000252
name: ALDH1B1
type: Species
initial concentration: NaN

metaR ACNAMPH
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
reversible: false

metaR GALASE19ly
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: beta-galactosidase, lysosomal
product: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r1664
fast: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110033#
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_de75cb63_daae_4841_a402_2fb23c70bff6
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:1544
type: Species
is: SBO:0000252
is: P05177
name: CYP1A2
initial concentration: NaN
has only substance units: false

metaM i e
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16382
is: SBO:0000247
initial amount: NaN
constant: false
name: iodide
boundary condition: false
is: HMDB12238
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708

http://identifiers.org/biomodels.db/MODEL1310110033#_205f23dd_a279_4fa3_ae94_bee8bbfb2258
is: SBO:0000252
boundary condition: true
name: PIK3C2G
type: Species
initial concentration: NaN
is encoded by: hsa:5288
is: O75747
has only substance units: false
initial amount: NaN
constant: false

metaM acgam6p c
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
type: Species
is: HMDB01062
boundary condition: false
constant: false
initial concentration: 1.0
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: CHEBI:57513

metaR PGCD
reactant: MODEL1310110033#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
name: phosphoglycerate dehydrogenase
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.95
modifier: MODEL1310110033#
fast: false

metaM 5adtststerone c
is: CHEBI:16330
is: SBO:0000247
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB02961

http://identifiers.org/biomodels.db/MODEL1310110033#_fe394fbc_07dc_4eb2_9b4f_079d90879a63
name: SLC23A2
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:9962
is: SBO:0000252
constant: false

metaR EX psylchol LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-glycocholic acid complex
type: Reaction

metaR r1665
kinetic law: MODEL1310110033#
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110033#
modifier: MODEL1310110033#

metaR SQLSr
type: Reaction
name: Squalene synthase
reversible: false
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.5.1.21
modifier: MODEL1310110033#
is described by: ECO:0000134
reactant: MODEL1310110033#
fast: false

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaR r0830
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110033#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185

metaR r0688
fast: false
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reactant: MODEL1310110033#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176

metaM pmtcoa r
initial concentration: 1.0
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:3454
boundary condition: false
is: HMDB01338
is: C00154
type: Species
is: SBO:0000247
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a0f889ac_e3d1_4208_acd2_5498c90d7bc3
is: SBO:0000252
name: HEXB
is: P07686
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:3074
constant: false
initial concentration: NaN

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_453a0ede_aa13_477d_acf3_31d180d323f7
initial amount: NaN
name: _AI291895_1_c
has only substance units: false
constant: false
is encoded by: hsa:AI291895
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM Tn antigen g
name: Tn antigen
initial amount: NaN
type: Species
boundary condition: false
is: C04383
is: SBO:0000247
notes: FORMULA: C8H14NO5X CHARGE: 0
initial concentration: 1.0
constant: false
has only substance units: false

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM fald c
type: Species
is: CHEBI:16842
boundary condition: false
name: formaldehyde
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: HMDB01426

http://identifiers.org/biomodels.db/MODEL1310110033#_3faed020_10c3_4f40_807b_52f201441a92
has only substance units: false
constant: false
name: _R39999_1_c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:R39999
type: Species
boundary condition: true

metaR CSNATp
is: SBO:0000176
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
is described by: ECO:0000304
product: MODEL1310110033#
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.7

metaR r0142
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
kinetic law: MODEL1310110033#

metaM dolmanp U r
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
has only substance units: false
is: CHEBI:15809
name: Dolichyl phosphate D-mannose, human uterine homolog

metaM gpail hs c
initial amount: NaN
boundary condition: false
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
has only substance units: false
is: SBO:0000247
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
is: CHEBI:17049
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_2f17eac5_2c1e_466d_8595_3dc9886935ef
name: CHKB
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1120
is: A0PJM6
constant: false
boundary condition: true
type: Species
initial amount: NaN

metaR LNLCCRNt
fast: false
type: Reaction
kinetic law: MODEL1310110033#
name: transport into the mitochondria (carnitine)
reversible: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM fald e
name: formaldehyde
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
is: HMDB01426
is: SBO:0000247
is: CHEBI:16842
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a8511596_9053_43ee_90f5_c703ff6a9592
constant: false
is encoded by: hsa:513
is: P30049
is: SBO:0000252
type: Species
initial amount: NaN
name: ATP5D
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR NRPPHRtu
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
name: Norepinephrine uniport
reversible: true
modifier: MODEL1310110033#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110033#

metaM pmtcoa x
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
is: CHEBI:57379
is: C00154
is: HMDB01338
initial concentration: 1.0
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

metaM so3 c
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: C00094
boundary condition: false
has only substance units: false
type: Species
name: Sulfite
is: SBO:0000247
initial amount: NaN
is: CHEBI:17137
constant: false
is: HMDB00240
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_6104e71b_d38f_4f40_a44d_3cb0cc09a4ab
is: P35270
name: SPR
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:6697
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_52551ea5_e27a_49be_970b_feb86cc2c3f1
is: SBO:0000252
is: P28329
boundary condition: true
has only substance units: false
name: CHAT
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:1103
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_3bdc2241_f7cf_4e8e_b97d_91eca106191e
initial amount: NaN
type: Species
is: O43280
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:11181
name: TREH

http://identifiers.org/biomodels.db/MODEL1310110033#_6d998bcd_21d6_424d_aa5f_d9fc27383dca
initial concentration: NaN
name: ADCY2
is: SBO:0000252
is: Q71UM8
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:108
constant: false
boundary condition: true

metaM xol7aone r
type: Species
is: HMDB01993
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17899
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
name: 7alpha-hydroxycholest-4-en-3-one

http://identifiers.org/biomodels.db/MODEL1310110033#_20c9186f_87b0_436c_9132_61329ef89d19
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: Q6YFQ2
name: COX6B2
is encoded by: hsa:125965
is: SBO:0000252
initial concentration: NaN

metaM accoa n
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
type: Species
constant: false
name: acetyl-CoA(4-)
is: HMDB01206
initial amount: NaN
is: CHEBI:57288
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_ebaa3340_00f1_4749_97f8_e63acecaf798
has only substance units: false
is encoded by: hsa:80308
is: SBO:0000252
boundary condition: true
name: FLAD1
type: Species
initial amount: NaN
is: Q8NFF5
constant: false
initial concentration: NaN

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_b3d69279_0fed_4638_b2c0_37499b7a62da
is: SBO:0000252
type: Species
is encoded by: hsa:37
boundary condition: true
initial amount: NaN
is: P49748
constant: false
name: ACADVL
initial concentration: NaN
has only substance units: false

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR r1660
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR CSNATr
type: Reaction
reversible: true
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: carnitine O-acetyltransferase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
is: SBO:0000176
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_a80051b6_edc8_4b45_97ab_f43de968c19a
constant: false
type: Species
is: SBO:0000252
name: _W74642_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:W74642
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_9392da11_927d_4337_b81f_c6370d1ae744
type: Species
constant: false
boundary condition: true
has only substance units: false
is: P53597
initial concentration: NaN
is encoded by: hsa:8802
name: SUCLG1
is: SBO:0000252
initial amount: NaN

metaM accoa m
is: CHEBI:57288
has only substance units: false
boundary condition: false
is: C00024
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB01206
name: Acetyl-CoA
type: Species
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaR RE1526M
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1526

http://identifiers.org/biomodels.db/MODEL1310110033#_e13387ac_6d95_449a_9768_1cb537e53ea5
constant: false
has only substance units: false
is: SBO:0000252
name: GNS
initial concentration: NaN
initial amount: NaN
type: Species
is: Q7Z3X3
boundary condition: true
is encoded by: hsa:2799

http://identifiers.org/biomodels.db/MODEL1310110033#_c37bf08b_b62d_4bd4_a6f4_0fb34a3e7fe0
initial amount: NaN
initial concentration: NaN
type: Species
is: H0YMZ7
boundary condition: true
has only substance units: false
is encoded by: hsa:5151
constant: false
name: PDE8A
is: SBO:0000252

metaM dadp n
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:57667
constant: false
name: dADP(3-)
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM dadp m
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: dADP(3-)
constant: false
is: HMDB01508
is: CHEBI:57667
initial concentration: 1.0

metaR r1661
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false

metaR r0834
is version of: http://identifiers.org/ec-code/3.5.4.16
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
reactant: MODEL1310110033#
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_e8579811_0a24_4cee_8059_f7a71dd33293
is encoded by: hsa:AI348006
boundary condition: true
type: Species
name: _AI348006_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaM pro L c
boundary condition: false
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17203
has only substance units: false
initial amount: NaN
name: L-proline

metaR r0836
modifier: MODEL1310110033#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16

http://identifiers.org/biomodels.db/MODEL1310110033#_63e35f3a_2e15_456a_bfe8_5f3b1130696d
constant: false
initial amount: NaN
is: P30519
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:3163
name: HMOX2
initial concentration: NaN

metaM 5oxpro c
constant: false
has only substance units: false
type: Species
is: HMDB00267
is: SBO:0000247
is: CHEBI:57606
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 5-oxoprolinate

metaR GALSIDEtg
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
name: galactocerebroside intracellular transport
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ

metaR NACHEX27ly
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110033#
reversible: false

metaR PPM
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000176
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.2
name: phosphopentomutase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_262d0038_25d1_4254_b82e_575b5c282973
initial amount: NaN
is encoded by: hsa:3945
is: P07195
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
name: LDHB

metaR GCC2bim
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
fast: false
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
is: SBO:0000176
reversible: false

metaR TRPt
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
modifier: MODEL1310110033#
name: L-tryptophan transport
product: MODEL1310110033#
is: SBO:0000185
reversible: true

metaM o2 c
is: HMDB01377
constant: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
is: CHEBI:15379
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C00007
has only substance units: false

metaR r1659
reversible: true
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_80786dff_c993_48fb_aab7_b28dc3ee98b6
initial amount: NaN
boundary condition: true
constant: false
is: P00918
name: CA2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:760
type: Species
is: SBO:0000252

metaR SIAASE2ly
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110033#
fast: false
type: Reaction
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110033#
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_a4ae1dda_07f5_416f_899e_07c7f8898033
type: Species
is encoded by: hsa:25902
boundary condition: true
is: SBO:0000252
name: MTHFD1L
has only substance units: false
is: B2RD24
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_edc3c32b_94c6_452f_a410_d1051275670d
boundary condition: true
initial amount: NaN
constant: false
name: ALPL
is: B7Z4Y6
is encoded by: hsa:249
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_64f38b88_0823_4060_a284_3cb2d5d17445
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI640625
is: SBO:0000252
constant: false
type: Species
name: _AI640625_1_c

http://identifiers.org/biomodels.db/MODEL1310110033#_a6f5fd51_75fd_4f72_b67c_b908cfab802a
is encoded by: hsa:4952
boundary condition: true
name: OCRL
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q01968

metaR CSPG Atly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110033#
type: Reaction
fast: false
kinetic law: MODEL1310110033#
name: chondroitin sulfate A transport, extracellular to lysosome
reversible: false
is: SBO:0000185
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_a5988fe7_dc7b_47fa_9991_7b7f0c8a0ab2
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI926493
boundary condition: true
type: Species
name: _AI926493_1_c
has only substance units: false
initial concentration: NaN

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_99834959_82a7_4557_8bb9_4202e0b0a681
type: Species
is encoded by: hsa:2583
name: B4GALNT1
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q59FK0

http://identifiers.org/biomodels.db/MODEL1310110033#_46ed561a_b6bd_48b6_8b59_4061ca74abba
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: SLC26A6
is: Q548A7
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:65010

metaR FACOAL180i
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: C180 fatty acid activation
type: Reaction
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110033#
fast: false

metaR r1658
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_61edb2da_cba1_4a2b_9c13_a21067c739d9
is: P27707
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1633
is: SBO:0000252
name: DCK

metaR P4508B11r
fast: false
reversible: false
reactant: MODEL1310110033#
name: sterol 12-alpha-hydroxylase
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
modifier: MODEL1310110033#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.14.13.95

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_f0f0b829_6fb2_4585_8330_1d2092a61cec
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P49327
constant: false
is encoded by: hsa:2194
name: FASN
has only substance units: false

metaM o2 e
type: Species
is: C00007
is: HMDB01377
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
has only substance units: false
is: CHEBI:15379
is: SBO:0000247

metaM 5oxpro e
boundary condition: false
constant: false
is: CHEBI:57606
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: HMDB00267
name: 5-oxoprolinate
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR THYMDtm
name: thymd transport
fast: false
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000269

metaR r0838
kinetic law: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: Free diffusion
is version of: http://identifiers.org/ec-code/3.1.2.4
type: Reaction
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:

metaR ASPDTDe
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
name: D-aspartate transport, extracellular
type: Reaction
fast: false
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110033#

metaM xol7aone c
name: 7alpha-hydroxycholest-4-en-3-one
type: Species
is: CHEBI:17899
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
boundary condition: false
initial amount: NaN
is: HMDB01993
is: SBO:0000247

metaR N3Tg
reactant: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.122
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_fdf2587d_f190_48f4_9a07_2b59ac54b9ae
constant: false
name: ALDH3B1
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P43353
is encoded by: hsa:221
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_e009ce08_2d7b_4718_b2d9_5581969675e9
type: Species
boundary condition: true
name: _AA278423_1_m
has only substance units: false
is encoded by: hsa:AA278423
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaM malthx e
type: Species
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: C01936
name: Maltohexaose
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_c122e50b_7f41_4df4_af1d_eb720a3942db
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:39
initial amount: NaN
type: Species
boundary condition: true
is: Q9BWD1
name: ACAT2
initial concentration: NaN

metaR INSTt4 2
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
modifier: MODEL1310110033#
reversible: true
name: inositol transport via sodium symport
fast: false
is described by: ECO:0000006
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_4f9ffabf_c0e1_40d7_b0ca_16d7fcb8b2ae
name: INPP1
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3628
type: Species
initial concentration: NaN
is: P49441

metaM o2s e
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
type: Species
is: HMDB02168
name: superoxide
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:18421
initial concentration: 1.0

metaR r2330
reactant: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaR r0839
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
reversible: true
product: MODEL1310110033#
name: Postulated transport reaction
is version of: http://identifiers.org/ec-code/1.3.1.70
modifier: MODEL1310110033#
is: SBO:0000185

metaM ksi deg28 l
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
boundary condition: false
type: Species
is: CHEBI:57455
name: keratan sulfate I, degradation product 28
has only substance units: false
is: HMDB01354

metaM hmgcoa x
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
has only substance units: false
is: HMDB01375
is: CHEBI:15467
type: Species
boundary condition: false
constant: false

metaR r0580
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.7
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
fast: false
reversible: true
reactant: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR r2331
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110033#
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_3e45a411_9a60_4de3_b381_23f1ecc748ac
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: PPCDC
is encoded by: hsa:60490
type: Species
has only substance units: false
is: Q96CD2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_61fe0297_507e_4044_84d3_1c83b9cdb176
type: Species
boundary condition: true
is encoded by: hsa:5151
constant: false
is: SBO:0000252
has only substance units: false
name: PDE8A
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_57e6206c_5fa4_4732_851a_b287ca9ef017
boundary condition: true
name: NDUFA12
type: Species
is: F8VQS7
is encoded by: hsa:55967
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM CE0713 m
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: HMDB02329
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30623
constant: false
type: Species
name: 3-oxolinoleoyl-CoA

metaR FRDPtr
reactant: MODEL1310110033#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reversible: true
product: MODEL1310110033#
fast: false
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000

metaR r1655
modifier: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_0f4cd8ff_74dc_4dee_8525_29974c423895
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: D3DX95
initial concentration: NaN
is encoded by: hsa:1103
is: SBO:0000252
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110033#_e4feb32b_8b78_44df_9fb0_12100021c7f0
type: Species
is: Q8N0X4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:171425
initial amount: NaN
name: CLYBL
constant: false

metaM dcacoa x
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)
is: C05274
has only substance units: false
is: HMDB06404
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:61430
initial concentration: 1.0
type: Species

metaR r2332
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110033#

metaM o2s c
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18421
constant: false
has only substance units: false
is: HMDB02168
type: Species

metaM sphs1p c
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
is: CHEBI:60119
has only substance units: false
is: HMDB00277
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a460069d_83d9_4e2a_84ba_8d7ee770b5d5
initial amount: NaN
is: A8K460
has only substance units: false
is encoded by: hsa:8398
initial concentration: NaN
type: Species
name: PLA2G6
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_dca331a5_2e88_40f7_aaec_307f45499aa4
is: P05091
name: ALDH2
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:217

metaR CYSt4
name: L-cysteine reversible transport via sodium symport
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110033#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_89872943_61e1_49eb_b3c5_3e72c7bcd254
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:6553
initial concentration: NaN
name: SLC9A5
initial amount: NaN
type: Species
has only substance units: false
is: Q9NSW9

http://identifiers.org/biomodels.db/MODEL1310110033#_033f1ff1_72c4_420a_be16_0710f2edf78d
initial concentration: NaN
name: OGDHL
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55753
type: Species
boundary condition: true
constant: false
is: Q9ULD0

http://identifiers.org/biomodels.db/MODEL1310110033#_639460c2_ed6a_4779_b502_5b58ceb02fc8
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79966
has only substance units: false
constant: false
name: SCD5
type: Species
initial amount: NaN
boundary condition: true
is: Q86SK9

metaM ksi deg41 l
initial concentration: 1.0
notes: FORMULA: C34H58N2O26 CHARGE: 0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00143
name: keratan sulfate I, degradation product 41
constant: false
is: CHEBI:12936
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_b6f36009_ed94_4549_bd35_9ec948ef91c3
is: P42336
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:5290
name: PIK3CA
boundary condition: true
initial amount: NaN

metaR r1654
reactant: MODEL1310110033#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
product: MODEL1310110033#

metaM pdx5p c
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:58589
name: Pyridoxine 5'-phosphate
is: C00627
is: SBO:0000247
is: HMDB01319
initial concentration: 1.0
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
constant: false

metaR RE1534M
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000176
type: Reaction
name: RE1534
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_9590a0b6_4733_48ba_b4a5_adc728e826dc
is: A7E2E0
initial concentration: NaN
type: Species
is encoded by: hsa:5293
name: PIK3CD
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_2dbdf291_8cd6_4a07_b1fc_8349fd080d12
constant: false
has only substance units: false
name: ADCY10
is: SBO:0000252
is encoded by: hsa:55811
is: F5GWS5
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR MECOALm
reversible: true
is described by: ECO:0000212
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#

metaR r2333
is: SBO:0000185
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR UDPGLCter
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: true
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
fast: false
reactant: MODEL1310110033#

metaR DUMPtn
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#

metaM mi3p D c
is: HMDB06814
boundary condition: false
name: 1D-myo-inositol 3-phosphate(2-)
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:58401
has only substance units: false

metaR r1657
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110033#

metaM dgmp m
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: dGMP
boundary condition: false
is: CHEBI:57673
is: C00362
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044

http://identifiers.org/biomodels.db/MODEL1310110033#_e190ce3f_119f_41c1_8470_66be1ecc8aa5
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:5313
is: SBO:0000252
boundary condition: true
name: PKLR
constant: false
is: P30613

metaM sphs1p e
type: Species
is: HMDB00277
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:60119
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f10de38e_1d94_489d_909a_fc3811c40fc4
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
type: Species
is: Q9Y6K8
is: SBO:0000252
is encoded by: hsa:26289
name: AK5

metaR r2334
reactant: MODEL1310110033#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_3ac35ec3_0da6_4c0b_b296_c0e67cedb662
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: DGKI
type: Species
is: O75912
is encoded by: hsa:9162

metaR r1656
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_e137dc1d_0599_4298_9230_68cd2ce2e0cc
type: Species
is encoded by: hsa:8608
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: O75452
has only substance units: false
constant: false
name: RDH16

metaR NADS2
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.3.5.1
product: MODEL1310110033#
name: NAD synthase (glutamine-hydrolysing)
is: SBO:0000176
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_067f1fd1_0dd5_480b_9614_3ec6fe0eb608
boundary condition: true
is: SBO:0000252
constant: false
name: SLC5A11
has only substance units: false
is: Q8WWX8
is encoded by: hsa:115584
type: Species
initial concentration: NaN
initial amount: NaN

metaM ksi deg17 l
initial amount: NaN
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
constant: false
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
is: HMDB00143
name: keratan sulfate I, degradation product 17
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_0100d0e1_69ee_4685_bb9c_12250546264d
is: Q9HBH5
constant: false
boundary condition: true
type: Species
is encoded by: hsa:57665
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: RDH14
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_07272487_b5b4_4cc8_88bd_580d28272352
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:3030
constant: false
is: SBO:0000252
type: Species
is: E9KL44
name: HADHA
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_9d2aaae2_acb4_47fb_b856_ec2fb68819ec
constant: false
initial amount: NaN
is: Q9NZK7
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:30814
name: PLA2G2E
boundary condition: true

metaR NACHEX1ly
modifier: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false

metaR r2335
is: SBO:0000185
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR BDHm
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
product: MODEL1310110033#
fast: false
reversible: true
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.30
modifier: MODEL1310110033#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase

metaR PRPNCOAHYDm
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
name: Propenoyl-CoA hydrolase (m)
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
product: MODEL1310110033#

metaR LCYSTAT
name: L-Cysteate:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110033#
fast: false
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000304
reactant: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM

metaM pro L m
is: HMDB00162
type: Species
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:17203
has only substance units: false
name: L-proline
initial amount: NaN

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM 5adtststerone r
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247
is: CHEBI:16330
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
type: Species
boundary condition: false
is: HMDB02961
has only substance units: false
initial concentration: 1.0

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR RE2079R
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110033#
name: RE2079
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_ca909ef4_6079_4393_b8f1_965df7d3558b
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8706
has only substance units: false
is: Q8TDY1
constant: false
name: B3GALNT1

http://identifiers.org/biomodels.db/MODEL1310110033#_1f98835b_ebc4_46e9_83ab_1a0f0bce817b
name: HSD17B4
is: E9PB82
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:3295

metaM HC00361 c
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
is: CHEBI:58335
boundary condition: false

metaR S6TASE10ly
modifier: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR DM fol
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaM xolest2 hs e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: cholesterol ester
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17002
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110033#_55be5d18_ac2b_4e9d_be0d_0ba1f400c6aa
name: _R06874_1_r
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:R06874
is: SBO:0000252

metaR r1384
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
name: Guanosine aminohydrolase EC:3.5.4.15
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110033#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:

metaM cspg a e
type: Species
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
boundary condition: false
is: HMDB00300
initial concentration: 1.0
is: C00106
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
initial amount: NaN
is: SBO:0000247
is: CHEBI:17568

metaR r0587
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
modifier: MODEL1310110033#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
product: MODEL1310110033#

metaR r2338
product: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reactant: MODEL1310110033#
reversible: true
type: Reaction

metaR THD1m
is version of: http://identifiers.org/ec-code/1.6.1.2
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
fast: false
product: MODEL1310110033#
name: NAD(P) transhydrogenase
reversible: true
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_71212657_ed79_4350_b0b5_7fe2465b04e0
name: FUT1
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:2523
is: Q6IZA2
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_e44dd2d5_cd09_46c3_8ca2_7fce6bec9bff
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:4711
constant: false
is: O43674
has only substance units: false
initial concentration: NaN
name: NDUFB5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_89d2f4fb_8d57_44d8_9b07_dae78dcd8118
type: Species
name: _100128062_1_m
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:100128062
has only substance units: false
initial concentration: NaN

metaM xolest2 hs c
boundary condition: false
name: cholesterol ester
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:17002

metaM dgmp c
type: Species
is: HMDB01044
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57673
is: C00362
boundary condition: false
is: SBO:0000247
name: dGMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false

metaR RE3421R
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#
name: RE3421

metaM dolmanp U c
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15809
type: Species
constant: false
boundary condition: false
has only substance units: false
name: Dolichyl phosphate D-mannose, human uterine homolog
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

metaR SPHK21c
reversible: false
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
name: sphingosine kinase 2
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.91
modifier: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR r0727
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110033#
reversible: false
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176

metaR DM dsT antigen g
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaR XYLtly
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
name: Xylose efflux from lysosome
product: MODEL1310110033#

metaR CLS hs
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
name: cardiolipin synthase (homo sapiens)
reversible: false
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
is: SBO:0000176

metaR KHte
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: KHte
is described by: ECO:0000134

metaM HC01603 c
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
name: 10-Formyltetrahydrofolate
is: C00234
initial concentration: 1.0
type: Species
has only substance units: false

metaM cspg b e
is: CHEBI:17568
has only substance units: false
is: HMDB00300
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial concentration: 1.0
boundary condition: false
type: Species
is: C00106

http://identifiers.org/biomodels.db/MODEL1310110033#_962d5a2a_a5a9_4e01_9626_43f67842d155
is: Q6LEN6
type: Species
name: CHAT
is: SBO:0000252
is encoded by: hsa:1103
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r0728
is: SBO:0000176
kinetic law: MODEL1310110033#
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_473789fe_c87d_4d05_8e3c_1a60a5e8d1ef
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:517
is: SBO:0000297
initial concentration: NaN
type: Species
has part: F8W7V3
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:9551

metaR GALSIDEtl
fast: false
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is: SBO:0000185
name: galactocerebroside intracellular transport
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_2cf81cb6_5fd0_44fc_8174_33b27d405880
is: SBO:0000252
name: ALDH1A3
has only substance units: false
type: Species
is: P47895
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:220
initial amount: NaN

metaM dgmp e
has only substance units: false
name: dGMP(2-)
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
is: CHEBI:57673
initial concentration: 1.0
is: HMDB01044
type: Species
is: SBO:0000247

metaM hs deg18 l
is: HMDB03178
is: C00032
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
type: Species
name: heparan sulfate, degradation product 18
is: CHEBI:17627
is: SBO:0000247
constant: false
boundary condition: false

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_1bbc65c8_d786_4e33_8f27_4ee523e0f814
initial amount: NaN
has only substance units: false
is: O75964
is encoded by: hsa:10632
constant: false
name: ATP5L
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_496d1e5b_0a82_4658_8e35_75b03b9d95e8
initial concentration: NaN
is: P30838
name: ALDH3A1
type: Species
constant: false
boundary condition: true
is encoded by: hsa:218
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_e0e5c1a9_4a4a_4d7c_886c_0e88a5557539
is encoded by: hsa:2531
initial amount: NaN
is: Q06136
has only substance units: false
constant: false
name: KDSR
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM hmgcoa m
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
type: Species
is: HMDB01375
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
has only substance units: false
is: CHEBI:15467

metaR r0729
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR RE3243R
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
name: RE3243
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_60e4bfcd_080a_4b88_b614_bcd5908e7b6f
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: P31639
name: SLC5A2
is: SBO:0000252
is encoded by: hsa:6524
initial amount: NaN
constant: false

metaR NRVNCt
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
kinetic law: MODEL1310110033#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110033#

metaR S6TASE16ly
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR DHPR2
reversible: false
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
name: 6,7-dihydropteridine reduction
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT

metaR DNDPt24m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110033#
name: dTDP transport via dADP antiport
reversible: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaR r0584
fast: false
is described by: ECO:0000000
modifier: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110033#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5

http://identifiers.org/biomodels.db/MODEL1310110033#_f3460f3a_dddf_4c7b_bef7_6725fe244942
has only substance units: false
initial amount: NaN
name: SLC12A4
is: F5H066
is encoded by: hsa:6560
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252

metaM hgentis c
type: Species
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
has only substance units: false
name: homogentisate
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16169
is: HMDB00130
initial concentration: 1.0
constant: false

metaR NACHEX9ly
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_8c9270ba_c429_428f_a7bd_09155a383b97
boundary condition: true
constant: false
is: P16260
name: SLC25A16
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:8034
is: SBO:0000252

metaR RE1233C
product: MODEL1310110033#
is: SBO:0000176
name: RE1233
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
kinetic law: MODEL1310110033#

metaM ksii core4 l
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57614
has only substance units: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
is: HMDB00189
initial amount: NaN
name: keratan sulfate II (core 4-linked)
boundary condition: false

metaM mlthf c
has only substance units: false
is: C00143
is: CHEBI:15636
name: 5,10-Methylenetetrahydrofolate
is: HMDB01533
boundary condition: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM hexdiac r
boundary condition: false
type: Species
constant: false
is: C08260
notes: FORMULA: C16H28O4 CHARGE: -2
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: hexadecanediocacid
is: HMDB00672

metaR ST6GALNAC27
is version of: http://identifiers.org/ec-code/2.4.99.7
is: SBO:0000176
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000304
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
reversible: false
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#

metaM dolp U r
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57683
type: Species

metaM h n
initial amount: NaN
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
constant: false
name: proton
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM HC01842 c
type: Species
constant: false
name: Phosphodimethylethanolamine
has only substance units: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: CHEBI:31997
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR ICDHy
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
modifier: MODEL1310110033#
name: isocitrate dehydrogenase (NADP)
kinetic law: MODEL1310110033#
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
product: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#

metaM gly e
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0
name: Glycine
is: HMDB00123
boundary condition: false
is: CHEBI:3339
is: C00037
initial concentration: 1.0

metaM 4abut c
boundary condition: false
is: C00334
has only substance units: false
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247
name: 4-Aminobutanoate
initial concentration: 1.0
is: CHEBI:3628
constant: false
type: Species
initial amount: NaN

metaM h m
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
is: CHEBI:24636
constant: false
name: proton
boundary condition: false
is: C00080
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_24ec5bad_bd90_4944_b7ae_3569ee2680f6
type: Species
is encoded by: hsa:285973
name: ATG9B
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q674R7
has only substance units: false
is: SBO:0000252

metaR CYSTA
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110033#
is: SBO:0000176
fast: false
name: cysteine transaminase
reversible: true
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
reactant: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000304

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_b11754f1_637a_468a_a478_cfc514069801
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:376497
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC27A1

http://identifiers.org/biomodels.db/MODEL1310110033#_0a64333e_bed6_41f3_b47f_0db49c04a219
name: _BE966236_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:BE966236
constant: false
has only substance units: false
type: Species

metaM adp n
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
name: ADP(3-)
boundary condition: false
initial concentration: 1.0
is: CHEBI:456216
constant: false

metaR HSD17B42x
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
reactant: MODEL1310110033#
fast: false
reversible: false
modifier: MODEL1310110033#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110033#
is described by: ECO:0000269
name: hydroxysteroid (17-beta) dehydrogenase 4
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_e3d73cd4_97f4_40f1_82e2_1c6790947b7f
name: SDHD
has only substance units: false
is encoded by: hsa:6392
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
is: O14521
type: Species

metaM gt3 hs g
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
initial concentration: 1.0
boundary condition: false
is: CHEBI:28424
type: Species
name: GT3

metaR GGH 10FTHF6GLUe
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
type: Reaction
modifier: MODEL1310110033#

metaM 3aib D e
boundary condition: false
constant: false
is: C03265
type: Species
has only substance units: false
initial concentration: 1.0
name: D-3-Amino-isobutanoate
initial amount: NaN
is: SBO:0000247
is: HMDB02299
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715

http://identifiers.org/biomodels.db/MODEL1310110033#_af1556cb_6791_4746_bae2_3e93a5cd909e
is encoded by: hsa:5959
is: SBO:0000252
is: Q92781
name: RDH5
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaR 3AIBTm
modifier: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.19
is: SBO:0000176
name: L-3-aminoisobutyrate transaminase, mitochondrial
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110033#
is described by: ECO:0000304
fast: false

metaR RE0830N
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: RE0830
is: SBO:0000176
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110033#

metaR EX 34hpp
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_ab4237f3_ad38_4127_b678_d4967b12fa2e
type: Species
constant: false
is: SBO:0000252
is: P11310
is encoded by: hsa:34
name: ACADM
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR NS26T2g
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
product: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
reversible: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.99.3

metaR r1106
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: true
product: MODEL1310110033#

metaM 4hpro LT m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00725
name: trans-4-hydroxy-L-proline
type: Species
is: CHEBI:18095
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false
constant: false
initial amount: NaN

metaM 4abut e
initial concentration: 1.0
has only substance units: false
is: C00334
type: Species
name: 4-Aminobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
is: HMDB00112
is: CHEBI:3628
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_f00a7cda_99b6_4a31_98e9_fcb05e55e195
name: SLC6A8
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6535
is: B4DIA3
type: Species
has only substance units: false
initial concentration: NaN

metaR PAFHe
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.1.47
name: Platelet-activating factor acetylhydrolase
notes: GENE_ASSOCIATION: (7941.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:8675689 NOTES:NJ
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110033#
reversible: false

metaM apoC Lys btn m
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03134
boundary condition: false
is: SBO:0000247
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: C05552
is: http://identifiers.org/pubchem.compound/7886
type: Species
has only substance units: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)

metaR SUCCTD
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR 4NPHte
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
name: xenobiotic transport

http://identifiers.org/biomodels.db/MODEL1310110033#_be64a31f_33ba_41b1_ae93_02f14211d450
is encoded by: hsa:5296
name: PIK3R2
type: Species
is: O00459
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

metaM txa2 e
name: thromboxane A2(1-)
has only substance units: false
is: HMDB01452
is: CHEBI:57445
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_80fcc24f_61d1_45f1_82cd_3e193aefb8d6
initial concentration: NaN
type: Species
initial amount: NaN
name: GGT7
is: SBO:0000252
is: A0PJJ9
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:2686

metaM srtn e
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:350546
boundary condition: false
name: serotonin(1+)
constant: false
is: HMDB00259
type: Species

metaM 3aib D c
is: HMDB02299
initial concentration: 1.0
has only substance units: false
is: C03265
constant: false
name: D-3-Amino-isobutanoate
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR HMGCOARc
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_5fff3128_cdcd_4f81_b456_ea1984433375
type: Species
constant: false
boundary condition: true
name: LDHAL6A
is: Q6ZMR3
has only substance units: false
initial amount: NaN
is encoded by: hsa:160287
is: SBO:0000252
initial concentration: NaN

metaR r0475
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#

metaR EX gq1balpha hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GQ1balpha (homo sapiens) exchange
type: Reaction

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_2df8a16f_1a41_4760_a273_dff461def2aa
initial amount: NaN
is encoded by: hsa:U52111
has only substance units: false
is: SBO:0000252
name: _U52111_1_c
type: Species
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_2d36c204_a54d_4302_a621_424e8dba2845
initial amount: NaN
boundary condition: true
is encoded by: hsa:27034
is: Q6ZWP6
is: SBO:0000252
type: Species
initial concentration: NaN
name: ACAD8
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_4ce5a7d9_5bca_4b99_891b_456607c774f1
type: Species
name: NDUFA11
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: C9JT23
constant: false
boundary condition: true
is encoded by: hsa:126328
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_be80a527_b022_4639_8658_3ab611da5153
is encoded by: hsa:5052
is: SBO:0000252
initial concentration: NaN
name: PRDX1
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaR PPNCL3
is described by: ECO:0000269
reversible: false
type: Reaction
name: phosphopantothenate-cysteine ligase
modifier: MODEL1310110033#
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.3.2.5

metaM nmn n
constant: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 INCHI: InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/p-1/t7-,8-,9-,11-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
has only substance units: false
initial amount: NaN
name: NMN(-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:14649
is: SBO:0000247
type: Species
is: HMDB00229

metaR r0474
type: Reaction
fast: false
reversible: true
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110033#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110033#

metaM h l
is: CHEBI:24636
constant: false
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00080
initial concentration: 1.0
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
has only substance units: false

metaR ACOAO7p
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
product: MODEL1310110033#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110033#
is described by: ECO:0000269
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
type: Reaction
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176

metaM adp r
constant: false
has only substance units: false
name: ADP(3-)
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
boundary condition: false
is: CHEBI:456216

metaR ST6GALNAC25
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.99.7
is: SBO:0000176
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
type: Reaction
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
reversible: false
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_ef957d16_51ad_4fc4_a47b_55e2ea2356e9
is encoded by: hsa:2618
has only substance units: false
name: GART
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: Q59HH3
boundary condition: true
is: SBO:0000252

metaM srtn c
constant: false
is: HMDB00259
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: serotonin(1+)
boundary condition: false
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species

metaM txa2 c
is: SBO:0000247
is: CHEBI:57445
initial concentration: 1.0
is: HMDB01452
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
type: Species
boundary condition: false
constant: false
name: thromboxane A2(1-)
initial amount: NaN
has only substance units: false

metaM ivcoa m
type: Species
name: Isovaleryl-CoA
is: CHEBI:57345
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01113
boundary condition: false

metaM succ m
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: C00042
name: Succinate
is: HMDB00254
type: Species
is: SBO:0000247
initial amount: NaN

metaM so4 m
name: sulfate
is: SBO:0000247
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
is: CHEBI:16189
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_03d10952_fd0f_41f4_8fbf_dd336f9a7b50
name: _AU149534_1_e
is: SBO:0000252
is encoded by: hsa:AU149534
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaR GALASE17ly
name: beta-galactosidase, lysosomal
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110033#_22197f04_646c_4985_b2c0_be6de676df10
initial concentration: NaN
is encoded by: hsa:506
type: Species
name: ATP5B
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P06576

http://identifiers.org/biomodels.db/MODEL1310110033#_b6d63db9_afed_43b4_97f0_c11b45fc1705
name: SLC26A6
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: Q9Y3Y1
is encoded by: hsa:65010

metaR ST6GALNAC26
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
is described by: ECO:0000304
is: SBO:0000176
fast: false
modifier: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (10610.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.7 Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.99.7

http://identifiers.org/biomodels.db/MODEL1310110033#_7b3c82d4_5a23_4de6_ba71_b78c8c107bf3
is: E2QC23
boundary condition: true
type: Species
is encoded by: hsa:23464
name: GCAT
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR ARACHt
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
type: Reaction
name: fatty acid transport via diffusion
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM ksii core4 e
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
initial amount: NaN
type: Species
is: CHEBI:17268
is: HMDB00211
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_894dc3ef_9d21_4e3b_ac3e_289d6c42ee92
is: P07203
boundary condition: true
name: GPX1
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:2876
initial concentration: NaN
constant: false

metaR r0472
type: Reaction
fast: false
reversible: true
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_bad85f83_b20f_4237_9307_72f137592362
has part: Q99643
has part: O14521
has part: P31040
is encoded by: hsa:6392
initial amount: NaN
constant: false
has only substance units: false
has part: P21912
initial concentration: NaN
is encoded by: hsa:6391
is encoded by: hsa:6390
type: Species
boundary condition: true
name: SDHA:SDHB:SDHC:SDHD
is: SBO:0000297
is encoded by: hsa:6389

metaM so4 l
initial concentration: 1.0
name: sulfate
constant: false
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
is: CHEBI:16189
initial amount: NaN
type: Species
is: HMDB01448
has only substance units: false

metaR MTHFD
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
kinetic law: MODEL1310110033#
name: methylenetetrahydrofolate dehydrogenase (NADP)
is described by: ECO:0000134
type: Reaction
product: MODEL1310110033#
is: SBO:0000176
reversible: true

metaM dctp n
name: dCTP
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00998
is: CHEBI:16311
boundary condition: false
is: C00458
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
type: Species
has only substance units: false

metaM gly m
boundary condition: false
initial amount: NaN
is: CHEBI:15428
is: HMDB00123
name: Glycine
initial concentration: 1.0
is: SBO:0000247
is: C00037
has only substance units: false
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_be831c1f_89c8_4e1d_9dbc_aea25f5a5968
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:3636
name: INPPL1
is: O15357
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_eac70aaa_8a72_4588_8e73_93023ed97b23
boundary condition: true
name: GMPPA
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29926
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_dc075e22_d2e7_4c48_b750_3f9a9901b7b4
is: P09972
initial amount: NaN
name: ALDOC
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:230

metaM hs deg9 l
boundary condition: false
is: HMDB06355
initial amount: NaN
constant: false
type: Species
is: CHEBI:18268
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 9
is: SBO:0000247
notes: FORMULA: C61H87N3O76S8 CHARGE: -10

metaR NDP7ex
reactant: MODEL1310110033#
reversible: false
product: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
name: nucleoside-diphosphatase (UDP), extracellular
fast: false
type: Reaction
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR CHSTEROLtrc
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
name: transport of cholesterol into the cytosol
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
is described by: ECO:0000134
reversible: true
fast: false
kinetic law: MODEL1310110033#

metaR GCC2am
modifier: MODEL1310110033#
name: glycine-cleavage complex (lipoamide), mitochondrial
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110033#
fast: false
type: Reaction
product: MODEL1310110033#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR r0170
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110033#
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.40
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21

http://identifiers.org/biomodels.db/MODEL1310110033#_92f74970_a905_417b_a2ea_a86c933da510
initial amount: NaN
name: _AI222095_1_e
is encoded by: hsa:AI222095
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true

metaM acmanap c
type: Species
name: N-acetyl-D-mannosamine 6-phosphate(2-)
is: CHEBI:58557
is: HMDB01121
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM succ c
name: Succinate
boundary condition: false
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: C00042
constant: false
initial amount: NaN
is: HMDB00254
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR r0470
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
fast: false

metaR MTHFC
is version of: http://identifiers.org/ec-code/1.5.1.5
is version of: http://identifiers.org/ec-code/3.5.4.9
reactant: MODEL1310110033#
name: methenyltetrahydrofolate cyclohydrolase
type: Reaction
kinetic law: MODEL1310110033#
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
modifier: MODEL1310110033#
is described by: ECO:0000134
product: MODEL1310110033#

metaM 2oxoadp m
initial amount: NaN
is: HMDB00225
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57499
name: 2-oxoadipate(2-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
type: Species

metaM xyl D c
initial concentration: 1.0
is: CHEBI:15936
initial amount: NaN
type: Species
name: aldehydo-D-xylose
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false
has only substance units: false

metaR LGTHL
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: false
name: lactoylglutathione lyase
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
is version of: http://identifiers.org/ec-code/4.4.1.5
fast: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_9564b209_aa92_4b95_9ae8_dea3e6ada5d5
constant: false
initial amount: NaN
is: Q9HCC0
initial concentration: NaN
is encoded by: hsa:64087
boundary condition: true
has only substance units: false
name: MCCC2
type: Species
is: SBO:0000252

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR RE1523M
product: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1523
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110033#
reactant: MODEL1310110033#

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR HSPGtly
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: heparan sulfate transport, extracellular to lysosome
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM f1a g
initial amount: NaN
initial concentration: 1.0
name: F1alpha
is: HMDB02917
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species
is: CHEBI:17151
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

metaR GALASE9ly
kinetic law: MODEL1310110033#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
type: Reaction
fast: false
reversible: false
product: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110033#_04ea90b2_56a7_4a15_b031_49410981a00b
is encoded by: hsa:7108
initial amount: NaN
has only substance units: false
is: O76062
type: Species
initial concentration: NaN
constant: false
name: TM7SF2
is: SBO:0000252
boundary condition: true

metaR P45027A1m
kinetic law: MODEL1310110033#
type: Reaction
name: Cytochrome P450 27
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false

metaM h x
boundary condition: false
has only substance units: false
type: Species
is: C00080
is: CHEBI:24636
constant: false
is: http://identifiers.org/pubchem.compound/3380
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
name: proton

metaR r1549
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110033#

metaR PYDXNK
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.35
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
reversible: false
modifier: MODEL1310110033#
name: pyridoxine kinase
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_3cba9dd7_e4d6_4279_bbf4_5ae59c5bef94
boundary condition: true
has only substance units: false
name: HSD3B7
is encoded by: hsa:80270
constant: false
is: SBO:0000252
is: Q9H2F3
initial concentration: NaN
type: Species
initial amount: NaN

metaR r0813
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
fast: false
kinetic law: MODEL1310110033#
reversible: false
modifier: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110033#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9

http://identifiers.org/biomodels.db/MODEL1310110033#_6c03a4e8_7e9f_473c_90c9_0eec0d9db2ad
initial amount: NaN
is: Q9NP59
type: Species
is encoded by: hsa:30061
has only substance units: false
initial concentration: NaN
name: SLC40A1
boundary condition: true
constant: false
is: SBO:0000252

metaM glcur l
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
is: CHEBI:15748
initial concentration: 1.0
initial amount: NaN
name: D-glucuronate
boundary condition: false
has only substance units: false
type: Species
is: HMDB00127
constant: false

metaR PI5P3K
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.154
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110033#
name: phosphatidylinositol-5-phosphate 3-kinase
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_28638a6a_47df_44e5_adde_8a3bfbdc9711
has only substance units: false
boundary condition: true
is encoded by: hsa:279
name: AMY2A
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is: P04746

http://identifiers.org/biomodels.db/MODEL1310110033#_26e86879_ea9b_4feb_bb93_af21d287561a
is: SBO:0000252
has only substance units: false
name: PIPOX
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:51268
initial concentration: NaN
constant: false
is: Q9P0Z9

metaR DHPM1
is described by: ECO:0000269
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
modifier: MODEL1310110033#
product: MODEL1310110033#
name: dihydropyrimidinase (5,6-dihydrouracil)
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.5.2.2
reactant: MODEL1310110033#
type: Reaction
fast: false

metaM xyl D e
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15936
name: aldehydo-D-xylose

metaM crn r
constant: false
type: Species
name: (R)-carnitine
has only substance units: false
is: HMDB00062
is: SBO:0000247
is: CHEBI:16347
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR GGH 6DHFe
kinetic law: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (6DHF), extracellular
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
type: Reaction

metaR r0812
reversible: true
product: MODEL1310110033#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#

metaM dad 2 c
is: SBO:0000247
is: CHEBI:17256
boundary condition: false
initial amount: NaN
name: 2-deoxyadenosine
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
constant: false
is: HMDB00101
has only substance units: false
type: Species

metaM 3aib D m
is: C03265
boundary condition: false
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB02299
initial amount: NaN
initial concentration: 1.0
name: D-3-Amino-isobutanoate

http://identifiers.org/biomodels.db/MODEL1310110033#_594f65ca_e349_4cdc_b33b_cf13b3786ba6
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: GBA
is encoded by: hsa:2629
boundary condition: true
is: B7Z6S1
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_cb0170e9_ccab_481a_9a1c_1f7affbc61c7
constant: false
is: O14561
type: Species
is encoded by: hsa:4706
name: NDUFAB1
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR PGDI
is version of: http://identifiers.org/ec-code/2.5.1.18
is described by: ECO:0000269
name: Prostaglandin-H2 D-isomerase [Precursor]
is version of: http://identifiers.org/ec-code/5.3.99.2
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#

metaR r1547
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000

metaR PETOHMm hs
reversible: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
modifier: MODEL1310110033#
name: phosphatidylethanolamine N-methyltransferase
type: Reaction
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.1.1.17
is described by: ECO:0000254
is: SBO:0000176
fast: false

metaM so4 c
name: sulfate
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16189
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01448
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

http://identifiers.org/biomodels.db/MODEL1310110033#_5351eb37_e4c3_4d30_b2bc_ee87dec24594
has only substance units: false
type: Species
boundary condition: true
name: ARSA
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P15289
is encoded by: hsa:410
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_b2f41cb2_30e7_4d0f_8a3b_a1da3a484336
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: ITPKC
is: Q96DU7
is encoded by: hsa:80271
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaR GLXtm
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
reversible: true
is described by: ECO:0000000
name: glyoxylate transport, mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD

metaM h r
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
type: Species
is: CHEBI:24636
is: SBO:0000247
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: C00080

metaM dhcrm hs c
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: dihydroceramide
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
is: CHEBI:31488
constant: false
has only substance units: false
initial amount: NaN

metaM f1a l
name: F1alpha
boundary condition: false
type: Species
has only substance units: false
is: HMDB02917
initial amount: NaN
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: CHEBI:17151
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_da0c9b6c_1877_43d3_bfff_614803f31a7b
is: O15305
is: SBO:0000252
name: PMM2
type: Species
has only substance units: false
constant: false
is encoded by: hsa:5373
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r0819
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_d27c3c7a_da3f_41b8_a416_307fa7a9fe3a
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI480132
type: Species
name: _AI480132_1_c
constant: false

metaR AMPtp
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is described by: ECO:0000000
is: SBO:0000185
name: AMP transporter, peroxisome
fast: false
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#
type: Reaction

metaM C02528 c
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:36234
type: Species
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial concentration: 1.0
is: HMDB00518
is: SBO:0000247
constant: false
name: chenodeoxycholate

metaM mal L e
initial concentration: 1.0
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00156
is: CHEBI:15589
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_5e5d223c_bda6_4f3d_953e_99b5a9aba2df
is: SBO:0000252
name: ABCD1
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P33897
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:215

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR r1548
fast: false
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true

metaM mal L c
is: CHEBI:15589
initial concentration: 1.0
name: (S)-malate(2-)
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaM crn x
initial concentration: 1.0
type: Species
is: C00318
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
boundary condition: false
name: L-Carnitine
is: HMDB00062
is: CHEBI:16347
constant: false

metaM sphgn c
is: SBO:0000247
is: CHEBI:57817
type: Species
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00269
name: sphinganine(1+)
boundary condition: false
constant: false

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR NACHEX18ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110033#
fast: false
is: SBO:0000176
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_c1a91f7b_86db_4869_bcfc_7b994cd4fa52
is: SBO:0000252
is: B5MCC7
initial amount: NaN
is encoded by: hsa:52
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ACP1
type: Species

metaR UGALNACtg
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
modifier: MODEL1310110033#
reversible: true
name: UDP-GalNAc Golgi transport via CMP antiport
product: MODEL1310110033#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

metaM accoa c
is: C00024
initial amount: NaN
is: HMDB01206
initial concentration: 1.0
boundary condition: false
is: CHEBI:57288
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_8a09ba62_15e5_40c4_80bc_c3b0eb56c824
type: Species
initial amount: NaN
is encoded by: hsa:122622
name: ADSSL1
is: SBO:0000252
is: B3KTV4
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaM so4 e
initial amount: NaN
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: sulfate
is: SBO:0000247
is: CHEBI:16189

http://identifiers.org/biomodels.db/MODEL1310110033#_402b724a_17be_413a_aa6c_05833a2c90fd
is: B1AM93
has only substance units: false
is encoded by: hsa:4702
constant: false
boundary condition: true
name: NDUFA8
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_0d271756_f456_45bd_8239_193a781880bf
is encoded by: hsa:471
boundary condition: true
name: ATIC
has only substance units: false
is: SBO:0000252
constant: false
is: P31939
initial amount: NaN
type: Species
initial concentration: NaN

metaR RE0830C
reversible: true
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is: SBO:0000176
reactant: MODEL1310110033#
name: RE0830
type: Reaction
fast: false

metaM succ e
name: succinate(2-)
is: CHEBI:30031
is: HMDB00254
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR GCHOLAte
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
name: bile acid intracellular transport

metaR r1767
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110033#
modifier: MODEL1310110033#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000185

metaR r0817
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#

metaM apoC Lys btn c
constant: false
has only substance units: false
is: HMDB00182
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C16H27N4O3SX CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:32551
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_f86513fe_e360_461a_9c95_1c1f4f0650c2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:55229
boundary condition: true
is: Q9NVE7
name: PANK4
type: Species
initial amount: NaN

metaM C02528 e
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: CHEBI:36234
name: chenodeoxycholate
is: HMDB00518
initial concentration: 1.0
has only substance units: false
type: Species

metaM cs a deg4 l
has only substance units: false
boundary condition: false
notes: FORMULA: C31H49NO29S CHARGE: -2
constant: false
is: HMDB01354
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
is: SBO:0000247
initial amount: NaN
is: CHEBI:57455
type: Species
initial concentration: 1.0

metaR C14STRr
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.1.70
fast: false
is: SBO:0000176
reversible: false
name: C-14 sterol reductase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ

http://identifiers.org/biomodels.db/MODEL1310110033#_4f05ed70_6c71_461f_8e7d_d11f48153255
has only substance units: false
is encoded by: hsa:10331
initial concentration: NaN
constant: false
name: B3GNT3
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9Y2A9

metaR r1546
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaR CHOLESACATc
fast: false
notes: GENE_ASSOCIATION: (8435.1) or (6646.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 143-144. charasuraisin, c. in short dissertation 19 (2008) NOTES:re-formation of cholesterol ester within enterocytes, then exit in chylomicrons into the lymph.
is described by: ECO:0000134
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#
name: esterification of cholesterol to cholesterol ester within enterocytes
modifier: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.26

http://identifiers.org/biomodels.db/MODEL1310110033#_3f2ae1a3_b94e_43ac_a987_fa90bc08145e
type: Species
is encoded by: hsa:6319
boundary condition: true
initial concentration: NaN
name: SCD
has only substance units: false
is: O00767
is: SBO:0000252
initial amount: NaN
constant: false

metaM glcur r
is: CHEBI:15748
initial amount: NaN
is: SBO:0000247
name: D-glucuronate
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false

metaR KSItly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#
fast: false
type: Reaction
product: MODEL1310110033#
name: keratan sulfate I transport, extracellular to lysosome
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_5191e563_ad4c_419a_86cc_b2fd9cc6d1dc
boundary condition: true
is: O15466
name: ST8SIA5
constant: false
is encoded by: hsa:29906
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM CE2422 m
type: Species
boundary condition: false
is: HMDB11123
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: CHEBI:28387
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial concentration: 1.0
constant: false

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM glcur c
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
boundary condition: false
is: CHEBI:15748
is: HMDB00127
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false

metaM glc D l
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:4167
initial concentration: 1.0
name: D-glucose
is: HMDB00122
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_235a78d3_922a_476e_8c19_45761460f80b
type: Species
is encoded by: hsa:8706
name: B3GALNT1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: B3KTQ4
has only substance units: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR RE3273C
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110033#
is: SBO:0000176
name: RE3273
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:

metaR LEUKTRD4t
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
name: leukotriene D4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
product: MODEL1310110033#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_5493bb43_d796_4189_b5de_cb24717892bb
has only substance units: false
is: SBO:0000252
is: O43678
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: NDUFA2
type: Species
is encoded by: hsa:4695

http://identifiers.org/biomodels.db/MODEL1310110033#_61fdc650_3af1_4c14_8c35_2a2bdce2ce99
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
name: _T83654_1_c
is: SBO:0000252
constant: false
is encoded by: hsa:T83654
boundary condition: true

metaR r1556
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR r0178
reactant: MODEL1310110033#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
is version of: http://identifiers.org/ec-code/2.5.1.21
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110033#
modifier: MODEL1310110033#

metaR DURIt
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000
name: deoxyuridine transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_fb001dab_7ed9_4a86_9513_e5d5a352c84c
has only substance units: false
name: COX7C
initial concentration: NaN
is encoded by: hsa:1350
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: P15954

metaM HC02202 c
name: prostaglandin A1(1-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
type: Species
is: CHEBI:57398
constant: false
initial amount: NaN
is: SBO:0000247

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM Rtotal2 e
initial concentration: 1.0
name: R total 2 position
is: SBO:0000247
boundary condition: false
is: CHEBI:3554
constant: false
type: Species
is: HMDB00244
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial amount: NaN
has only substance units: false
is: C00255

http://identifiers.org/biomodels.db/MODEL1310110033#_a1fa1e6f_fb58_408c_8b1b_7eec20c7d532
name: B3GALT5
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:10317
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_dc323a3d_7aa4_4836_8bdc_ffcce2e20704
constant: false
type: Species
is: Q9H2H9
initial concentration: NaN
is encoded by: hsa:81539
has only substance units: false
name: SLC38A1
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_20824a39_f18d_48df_af58_7fa98aed66c5
constant: false
is: Q8IYH3
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:3036
name: HAS1

http://identifiers.org/biomodels.db/MODEL1310110033#_be7872d8_a497_4e65_b57e_0f9fa00e3ae0
type: Species
initial amount: NaN
name: COX3
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4514
is: P00414
has only substance units: false
constant: false

metaM leu L m
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: L-leucine
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
is: CHEBI:15603

http://identifiers.org/biomodels.db/MODEL1310110033#_fb754a73_8134_4a17_9ec9_b698ca438786
name: UGP2
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:7360
initial concentration: NaN
type: Species
initial amount: NaN

metaM glcur e
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
is: HMDB00127
name: D-glucuronate
is: CHEBI:15748
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false

metaR ARABR
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
product: MODEL1310110033#
name: arabinose reductase
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.21

metaM hspg l
type: Species
is: CHEBI:17899
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
name: heparan sulfate proteoglycan
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01993
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_97c39184_da07_4476_a603_c06efeb466f9
initial concentration: NaN
is: O95498
initial amount: NaN
is encoded by: hsa:8875
type: Species
boundary condition: true
has only substance units: false
constant: false
name: VNN2
is: SBO:0000252

metaR r1554
kinetic law: MODEL1310110033#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r0179
reactant: MODEL1310110033#
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110033#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110033#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
product: MODEL1310110033#

metaM xyl D l
constant: false
initial concentration: 1.0
is: CHEBI:15936
has only substance units: false
is: SBO:0000247
name: aldehydo-D-xylose
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1

metaR r1553
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false

metaM 2hb e
initial concentration: 1.0
name: 2-Hydroxybutyrate
is: CHEBI:1148
constant: false
type: Species
has only substance units: false
is: HMDB00008
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: SBO:0000247

metaR LINKDEG2ly
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110033#

metaM gly x
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
boundary condition: false
name: glycine
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15428
is: HMDB00123
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a666fae5_8451_4402_a8ec_e1996a99018e
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51301
constant: false
type: Species
is: Q9P109
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: GCNT4

metaM CE4876 r
name: delta12-Prostaglandin J2
type: Species
has only substance units: false
is: CHEBI:57923
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR NDP7er
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
fast: false

metaM hs deg12 l
name: heparan sulfate, degradation product 12
is: C00032
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
constant: false
is: HMDB03178
is: CHEBI:17627
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_f46ebf73_77a2_4f24_abd5_2cf3222afe1d
name: PIP5K1C
is encoded by: hsa:23396
is: O60331
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true

metaR r0173
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
product: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.19
reactant: MODEL1310110033#
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
modifier: MODEL1310110033#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_35d58f8b_7b3d_4bce_8b77_a0b07f5ca550
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q96M60
is encoded by: hsa:196951
is: SBO:0000252
has only substance units: false
type: Species
name: C15orf33

metaM gt1c hs g
initial amount: NaN
is: SBO:0000247
name: GT1c
has only substance units: false
is: CHEBI:28648
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3

metaM sl L e
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:61289
name: (S)-3-sulfonatolactate(2-)
is: SBO:0000247
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
has only substance units: false

metaR r1552
is described by: ECO:0000000
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185

metaM na1 r
boundary condition: false
has only substance units: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: SBO:0000247
is: CHEBI:29101
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: sodium(1+)
is: HMDB00588

http://identifiers.org/biomodels.db/MODEL1310110033#_a4f32914_f7ef_40fa_af48_c7e5044d8f10
is: SBO:0000252
initial concentration: NaN
is: Q9HC21
boundary condition: true
is encoded by: hsa:60386
name: SLC25A19
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR BILIRED
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.24
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
modifier: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000176
name: Nad(p)h biliverdin reductase
reversible: false
kinetic law: MODEL1310110033#

metaM ksi deg1 l
boundary condition: false
is: HMDB00174
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
name: keratan sulfate I, degradation product 1
constant: false
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: CHEBI:18287

metaM mal L m
type: Species
constant: false
name: (S)-malate(2-)
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: SBO:0000247
is: HMDB00156
has only substance units: false
is: CHEBI:15589
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_1592c6dc_caca_4a94_9430_9b522ac70a49
is: SBO:0000252
is encoded by: hsa:1384
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
name: CRAT

metaM 2hb c
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: SBO:0000247
is: CHEBI:1148
is: HMDB00008
name: 2-Hydroxybutyrate
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR r1551
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#

metaR APOC LYS BTNPm
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
name: proteolysis of apoC-Lys-btn, mitochondrial
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
fast: false

metaR PI45P4P
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_ed30b225_9a69_4321_bf6f_62f4af1a32bf
initial concentration: NaN
type: Species
is encoded by: hsa:170712
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: COX7B2
is: Q8TF08

http://identifiers.org/biomodels.db/MODEL1310110033#_8ba3fd71_92b9_46b1_b8cb_b7deed7447a9
name: PYCR1
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5831
constant: false
initial concentration: NaN
is: A6NFM2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_7783418e_fdbf_427f_affd_41435d12b26f
is encoded by: hsa:10380
initial amount: NaN
is: O95861
initial concentration: NaN
name: BPNT1
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaM txa2 r
name: thromboxane A2(1-)
is: CHEBI:57445
type: Species
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
has only substance units: false
initial concentration: 1.0
is: HMDB01452
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM glc D r
is: HMDB00122
is: CHEBI:4167
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_363b70fd_d191_43de_bbda_2e34f4978933
initial amount: NaN
type: Species
is: P36269
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2687
constant: false
name: GGT5
has only substance units: false

metaM sl L c
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
has only substance units: false
name: (S)-3-sulfonatolactate(2-)
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:61289
constant: false

metaR CYSGLYexR
is: SBO:0000185
kinetic law: MODEL1310110033#
type: Reaction
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
name: L-cysteine/glycine reversible exchanger
reversible: true
modifier: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT

metaM adp c
is: SBO:0000247
is: CHEBI:16761
name: ADP
is: HMDB01341
constant: false
has only substance units: false
is: C00008
boundary condition: false
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN
type: Species
initial concentration: 1.0

metaR PItn
name: phosphate transport, nuclear
reversible: true
product: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110033#
fast: false
type: Reaction
reactant: MODEL1310110033#

metaM HC02202 e
name: prostaglandin A1(1-)
type: Species
is: CHEBI:57398
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_eb98edad_980f_4ef9_9e38_8288fec0e4b3
is: SBO:0000252
has only substance units: false
name: _AA081045_1_e
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:AA081045
type: Species

metaM HC01397 x
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: CHEBI:27402
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_64acc1b3_2e64_42a8_b669_f33dce43c1b3
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is: Q8IWX5
initial amount: NaN
is: SBO:0000252
type: Species
name: SGPP2
is encoded by: hsa:130367

http://identifiers.org/biomodels.db/MODEL1310110033#_c15c9494_b116_4db0_b0ae_0bbf76e2b6c7
constant: false
name: ACOT7
type: Species
is: O00154
initial amount: NaN
is encoded by: hsa:11332
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM xol7ah2al c
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB06894
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
is: SBO:0000247
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
is: CHEBI:27428
has only substance units: false

metaM hs deg25 l
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H37O21 CHARGE: -1
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:16126

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_f8c01c76_2138_48ae_952e_07e4d849ed36
name: PFKM
initial amount: NaN
has only substance units: false
is: P08237
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:5213
constant: false

metaR ENO
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP
name: enolase
reactant: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.2.1.11
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
fast: false

metaR PItg
product: MODEL1310110033#
is: SBO:0000185
name: phosphate transport, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false

metaR 3HBCOAHLm
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM

metaM hs deg8 l
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
has only substance units: false
boundary condition: false
constant: false
name: heparan sulfate, degradation product 8
is: CHEBI:16126

metaM udpg c
constant: false
name: UDPglucose
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0
is: C00029
is: CHEBI:58367
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB00286

http://identifiers.org/biomodels.db/MODEL1310110033#_3c7cf4e9_b324_4e53_89be_48060bf47265
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM h e
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
is: CHEBI:24636
boundary condition: false
name: proton
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
is: C00080

metaR r1443
reversible: false
name: EC:1.3.3.6
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaM leu L c
is: SBO:0000247
name: L-leucine
type: Species
is: HMDB00687
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_ba579aaa_db86_45c2_a085_f111ff453205
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PDE1B
type: Species
is: Q7Z364
is: SBO:0000252
is encoded by: hsa:5153
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_5f82877c_1f5d_4c1b_b738_01f51f83be3b
name: CA13
is: Q8N1Q1
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:377677
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_d01a1310_4337_4972_92fe_a93092e3cbc5
has only substance units: false
is encoded by: hsa:3615
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: IMPDH2
initial amount: NaN
is: P12268

http://identifiers.org/biomodels.db/MODEL1310110033#_b341b6d7_76c1_4f6c_ad6c_0d99c02d092e
name: PEMT
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:10400
type: Species
is: SBO:0000252

metaM inost c
is: HMDB00211
is: CHEBI:17268
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial concentration: 1.0
initial amount: NaN
name: myo-inositol
constant: false
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

metaR KSII CORE2tly
product: MODEL1310110033#
type: Reaction
name: keratan sulfate II (core 2) transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: false
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000

metaM gluside hs l
name: D-glucosyl-N-acylsphingosine
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:18368
type: Species

metaM HC01397 m
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
has only substance units: false
initial amount: NaN
name: (S)-3-Hydroxyhexadecanoyl-CoA
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27402
type: Species

metaR DM anth
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_bf1645c2_7635_43b6_a4b2_f358b20d3037
is encoded by: hsa:10559
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: SLC35A1
initial amount: NaN
is: SBO:0000252
is: P78382

metaM 4abut m
name: 4-Aminobutanoate
is: SBO:0000247
is: HMDB00112
is: C00334
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:16865

http://identifiers.org/biomodels.db/MODEL1310110033#_658f795d_89ff_4096_aead_7086ad659097
is: SBO:0000252
is encoded by: hsa:175
constant: false
initial concentration: NaN
has only substance units: false
type: Species
name: AGA
boundary condition: true
initial amount: NaN
is: P20933

metaR GTHDH
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
name: Glutathione dehydrogenase (dehydroascorbate reductase)
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
kinetic law: MODEL1310110033#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_adbd3327_47f9_409e_a7b0_d797ec072c36
is: SBO:0000297
name: ADH1A:ADH1B
constant: false
has part: P07327
has only substance units: false
boundary condition: true
is encoded by: hsa:124
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_16134e04_37cd_4943_bb6e_9ae2a5e0f607
type: Species
is encoded by: hsa:7001
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: PRDX2

metaM h g
is: CHEBI:24636
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
name: proton
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0

metaM leu L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
is: CHEBI:15603
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00687
initial concentration: 1.0
name: L-leucine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_09268c7e_939b_41da_a60b_c6f341724fa8
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:5295
type: Species
initial concentration: NaN
name: PIK3CA:PIK3R1
is: SBO:0000297
has part: P27986
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_e66abe2b_e1b9_4361_b6c5_96ea7dc65ec7
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:BE042354
name: _BE042354_1_m
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_d5c7afbc_101b_422a_a1b1_567a23222374
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
type: Species
is encoded by: hsa:515
is encoded by: hsa:518
is: SBO:0000297
is encoded by: hsa:10476
initial amount: NaN
initial concentration: NaN
constant: false
has part: P24539
has only substance units: false
boundary condition: true
has part: P18859
has part: O75947

http://identifiers.org/biomodels.db/MODEL1310110033#_bb6eee33_a58e_461e_b662_81e4a16c7586
initial concentration: NaN
has only substance units: false
name: SLC8A3
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6547
is: SBO:0000252

metaR GLYtp
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
name: glycine passive transport to peroxisome
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
fast: false

metaM inost e
has only substance units: false
is: CHEBI:17268
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
initial amount: NaN
initial concentration: 1.0
constant: false
name: myo-inositol
is: SBO:0000247
type: Species
is: HMDB00211
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a43bd1b1_5cec_4f3a_a7f3_2beb9cb10246
initial amount: NaN
is encoded by: hsa:AA676725
name: _AA676725_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_e502573f_4728_4b8a_a15a_8dc38974b6ec
is: SBO:0000252
initial amount: NaN
is: Q9ULC5
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:51703
name: ACSL5

http://identifiers.org/biomodels.db/MODEL1310110033#_34a989f2_9e1b_4658_bb23_37cb4b04a242
type: Species
is encoded by: hsa:6530
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC6A2
is: SBO:0000252
is: Q96KH8
boundary condition: true

metaR SARCStm
is: SBO:0000185
name: Sarcosine transport (mitochondrial)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110033#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_88219450_6670_436c_940b_5063b05254cf
is: P24539
name: ATP5F1
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:515
initial amount: NaN
boundary condition: true

metaM ca2 e
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
constant: false
has only substance units: false
boundary condition: false
is: HMDB00464
is: CHEBI:29108
name: calcium(2+)
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR GLYtm
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
fast: false
name: glycine passive transport to mitochondria
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR GLCAASE1ly
fast: false
modifier: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110033#

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_cd24c1ec_be25_4b23_acc3_2359f2774be7
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O95263
initial concentration: NaN
type: Species
initial amount: NaN
name: PDE8B
is encoded by: hsa:8622
constant: false

metaM adp m
name: ADP
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:456216
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01341
has only substance units: false
type: Species
is: C00008
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_63328e49_0624_4db3_8bfd_4ed29ff802a9
boundary condition: true
name: CA9
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:768
is: SBO:0000252
type: Species
constant: false
is: Q16790

metaR FAOXC10C8x
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_00276809_353c_4736_9f14_bfd7ff0b438e
is: SBO:0000252
type: Species
name: PRPS1
is: P60891
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:5631

metaM dctp c
name: dCTP
has only substance units: false
is: CHEBI:16311
type: Species
initial concentration: 1.0
is: HMDB00998
boundary condition: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
constant: false
is: SBO:0000247
is: C00458
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_209c0b55_b70c_4536_8ce1_ab1400df4ed7
type: Species
name: SULT1A2
is encoded by: hsa:6799
boundary condition: true
constant: false
is: P50226
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM hspg e
boundary condition: false
initial amount: NaN
is: CHEBI:15699
is: SBO:0000247
name: heparan sulfate proteoglycan
has only substance units: false
initial concentration: 1.0
is: HMDB00719
constant: false
type: Species
notes: FORMULA: C79H113N5O101S12X CHARGE: -13

metaM ca2 c
constant: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
is: HMDB00464
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:29108
boundary condition: false

metaR r2039
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR ACACt2
is described by: ECO:0000269
name: acetoacetate transport via proton symport
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#

metaM hs deg20 l
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16126
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
name: heparan sulfate, degradation product 20
constant: false
initial concentration: 1.0

metaR CYTK2n
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
name: cytidylate kinase (dCMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_b791dfd1_a2a5_4e37_b479_9b1a41fb1c3a
type: Species
constant: false
name: SLC1A6
has only substance units: false
is: SBO:0000252
is: P48664
is encoded by: hsa:6511
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM xol7ah2al m
initial concentration: 1.0
has only substance units: false
is: CHEBI:27428
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
initial amount: NaN
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
type: Species
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_31ec498d_ed13_4e9b_a88d_ab78ab5ffe91
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9551
is: P56134
type: Species
constant: false
initial amount: NaN
name: ATP5J2

metaR 4MOPte
product: MODEL1310110033#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
fast: false
name: Transport of 4-methyl-2-oxopentanoate
reactant: MODEL1310110033#

metaM succ x
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
is: C00042
is: HMDB00254
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:30031
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR r1445
product: MODEL1310110033#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110033#
name: EC:1.3.3.6
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110033#

metaR BPNT
name: 3',5'-bisphosphate nucleotidase
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000269
kinetic law: MODEL1310110033#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.3.7

metaR NACHEX15ly
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false

metaM cspg b l
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial amount: NaN
constant: false
is: HMDB02183
is: CHEBI:36005
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_8f87056a_0dc4_4013_bc30_849096e6a139
initial concentration: NaN
is: Q8IZV5
is: SBO:0000252
type: Species
has only substance units: false
name: RDH10
initial amount: NaN
is encoded by: hsa:157506
boundary condition: true
constant: false

metaM cs a deg3 l
has only substance units: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: SBO:0000247
initial concentration: 1.0
is: HMDB00127
boundary condition: false
type: Species
is: CHEBI:15748
initial amount: NaN
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3

http://identifiers.org/biomodels.db/MODEL1310110033#_737794c5_041e_420e_ba6e_1a56699241cc
is: SBO:0000252
is encoded by: hsa:1384
initial amount: NaN
is: P43155
initial concentration: NaN
constant: false
type: Species
name: CRAT
has only substance units: false
boundary condition: true

metaM h c
is: CHEBI:24636
is: C00080
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
name: proton

metaM odecoa c
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
is: CHEBI:3793
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_5831c2d7_d43e_4ffa_952e_6161f912df56
is encoded by: hsa:9615
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: GDA
type: Species
constant: false
is: Q9Y2T3
initial amount: NaN
boundary condition: true

metaM HC01409 m
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27540
is: SBO:0000247
boundary condition: false
name: Hexanoyl-CoA
constant: false
has only substance units: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270

http://identifiers.org/biomodels.db/MODEL1310110033#_76b3168c_d4be_420d_8bbc_1e1611a0be94
is encoded by: hsa:9962
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9UGH3
name: SLC23A2
initial concentration: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR r1444
reversible: false
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110033#
name: EC:1.3.3.6
product: MODEL1310110033#

metaR 1PPDCRp
kinetic law: MODEL1310110033#
is described by: ECO:0000000
fast: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
is: SBO:0000176
reversible: false
product: MODEL1310110033#
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_dd9454e1_fd79_4476_8d8a_8c762327a82e
initial amount: NaN
boundary condition: true
is encoded by: hsa:4830
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: NME1
initial concentration: NaN

metaM gluside hs r
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: CHEBI:18368
constant: false
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_dd07f398_de2e_45bd_9dd1_70468eb70dbc
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:LOC728997
initial amount: NaN
type: Species
constant: false
name: _LOC728997_1_c
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_736f3204_0c55_41aa_951c_4680d562ccce
has only substance units: false
constant: false
name: _AI824319_1_r
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI824319

metaR r0809
modifier: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
is: SBO:0000185
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110033#
product: MODEL1310110033#
name: Facilitated diffusion

metaR FAOXC80
fast: false
name: Beta oxidation of med/long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110033#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reactant: MODEL1310110033#
reversible: false
type: Reaction

metaR SIAASE3ly
reactant: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110033#
is: SBO:0000176
fast: false
modifier: MODEL1310110033#
product: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
type: Reaction

metaM c6dc c
is: HMDB04047
notes: FORMULA: C13H22NO6 CHARGE: -1
type: Species
is: C14143
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: adipoyl carnitine
initial amount: NaN
has only substance units: false
constant: false

metaR GLCAASE8ly
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110033#
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110033#
name: beta-glucuronidase, lysosomal
is: SBO:0000176

metaR 4MOPt2im
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false

metaR r1117
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: Facilitated diffusion
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_9ddc6016_123b_4493_8978_59c81c27641f
is: Q96SL4
is encoded by: hsa:2882
type: Species
initial amount: NaN
boundary condition: true
name: GPX7
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM btn c
boundary condition: false
name: Biotin
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
is: C00120
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:3420
type: Species
is: HMDB00030
constant: false

metaR r0488
reactant: MODEL1310110033#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_795fa065_a885_4052_a644_1ec71eb4b397
initial concentration: NaN
name: ASAH1
type: Species
has only substance units: false
is: Q96AS2
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:427
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_682112b8_a729_4745_bf2e_644c978ebe58
is encoded by: hsa:AD000092
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _AD000092_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_59387744_cd16_43c4_86a3_01b53e40cc8d
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: B7Z2M9
type: Species
constant: false
is encoded by: hsa:8525
boundary condition: true
name: DGKZ

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM fpram c
is: C04640
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:58478
is: HMDB06211
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR GLNtm
is described by: ECO:0000000
name: L-glutamine transport via electroneutral transporter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
product: MODEL1310110033#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false

metaR GQ1BALPHAtg
product: MODEL1310110033#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
name: gq1balpha hs intracellular transport

metaM fdp c
has only substance units: false
type: Species
is: C00354
name: D-Fructose 1,6-bisphosphate
is: SBO:0000247
constant: false
is: CHEBI:16905
initial amount: NaN
is: HMDB01058
boundary condition: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
is: http://identifiers.org/pubchem.compound/3647
initial concentration: 1.0

metaM 2mbcoa m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 2-methylbutanoyl-CoA(4-)
boundary condition: false
is: HMDB01041
type: Species
constant: false
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: CHEBI:57336

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaM paf hs e
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
type: Species
is: CHEBI:36707
is: SBO:0000247
initial amount: NaN
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false

metaR THP2Ctp
fast: false
reversible: true
is described by: ECO:0000000
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000185

metaM tyr L c
initial concentration: 1.0
name: L-tyrosine
is: CHEBI:17895
type: Species
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
has only substance units: false
boundary condition: false
is: HMDB00158
initial amount: NaN

metaR PAIL45P HStn
reversible: true
reactant: MODEL1310110033#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR GGH 7THFe
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
name: Gamma-glutamyl hydrolase (7THF), extracellular
reactant: MODEL1310110033#
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_bab96bd2_7a12_42fc_98a9_fa1b5129ef13
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5831
is: A6NFM2
initial amount: NaN
boundary condition: true
name: PYCR1
is: SBO:0000252

metaR MAL Lte
kinetic law: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
name: Transport of L-malate
fast: false

metaM btn e
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
initial amount: NaN
constant: false
name: Biotin
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00120
is: CHEBI:3420
type: Species

metaR GLCNACASE2ly
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction

metaR GQ1BALPHAte
reactant: MODEL1310110033#
name: gq1balpha hs transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
reversible: true

metaM dcmp c
is: SBO:0000247
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
has only substance units: false
is: CHEBI:57566
boundary condition: false
is: C00239
name: dCMP
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

metaM c6dc e
is: C14143
type: Species
initial concentration: 1.0
is: SBO:0000247
name: adipoyl carnitine
constant: false
initial amount: NaN
notes: FORMULA: C13H22NO6 CHARGE: -1
is: HMDB04047
has only substance units: false
boundary condition: false

metaR NTD7e
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110033#
is described by: ECO:0000269
modifier: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (AMP), extracellular
fast: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_4f2038e1_09c3_4687_8519_e282ed1fc296
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:284111
is: Q86YT5
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: SLC13A5

http://identifiers.org/biomodels.db/MODEL1310110033#_d357c022_786b_48cd_b6d8_da2198635d46
is: Q5SYN6
has only substance units: false
is encoded by: hsa:6581
constant: false
initial concentration: NaN
name: SLC22A3
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_dea67184_a626_4058_a541_45937ff129f7
type: Species
has only substance units: false
name: HMGCS1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3157
constant: false
boundary condition: true
is: SBO:0000252

metaR r0051
product: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110033#
fast: false
reversible: true
is described by: ECO:0000000
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:

metaR r2194
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#

metaR TALA
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.2
reversible: true
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
name: transaldolase

metaR SMPD4
type: Reaction
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
reversible: false
kinetic law: MODEL1310110033#
name: sphingomyelinase

http://identifiers.org/biomodels.db/MODEL1310110033#_6690d818_5643_4ba6_a277_808d16df692d
type: Species
is encoded by: hsa:6817
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SULT1A1

http://identifiers.org/biomodels.db/MODEL1310110033#_8ae0d83c_d533_4651_8e19_917f2ff155cf
boundary condition: true
is encoded by: hsa:248
type: Species
has only substance units: false
is: P09923
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ALPI
constant: false

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_110b537b_094b_4866_9bcb_c6d9e2361df3
name: PHGDH
initial amount: NaN
is encoded by: hsa:26227
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: O43175
initial concentration: NaN

metaR r1428
is described by: ECO:0000000
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
name: Free diffusion
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:

metaM mi1p D n
name: 1D-myo-inositol 1-phosphate(2-)
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
boundary condition: false
is: CHEBI:58433
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB02985
initial amount: NaN

metaR r2193
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110033#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_98f5ec5d_b689_4349_a67d_d7e79d595e65
name: ECI2
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10455
type: Species
is: O75521
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_f66e5c8b_b707_49ff_aeb5_0e42cd1fa104
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: GBA
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2629
is: B7Z5G2

metaR GTHRDt
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
name: Glutathione transport into mitochondria
is: SBO:0000185
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#

metaR HGNTOR
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.13.11.5
modifier: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000176
reversible: false

metaR NADtn
name: NAD transport, nuclear through pores
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110033#

metaM co2 x
boundary condition: false
has only substance units: false
initial amount: NaN
name: carbon dioxide
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
is: CHEBI:16526
is: SBO:0000247

metaR r1429
is: SBO:0000185
kinetic law: MODEL1310110033#
name: Free diffusion
type: Reaction
product: MODEL1310110033#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110033#
is described by: ECO:0000000

metaM fucgalacglcgalgluside hs g
name: Type IH glycolipid
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01167
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17158

metaR ICDHyrm
type: Reaction
name: Isocitrate dehydrogenase (NADP+)
reversible: true
modifier: MODEL1310110033#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_b46ab285_e47b_47bb_a63c_1a1757ab30cc
type: Species
name: _HG2846_HT2983_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:HG2846-HT2983
boundary condition: true
is: SBO:0000252

metaM ditp n
name: dITP(4-)
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
boundary condition: false
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:61382
is: HMDB03537
is: SBO:0000247

metaR r2196
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_8390401e_3ef0_4be2_be9e_d42b80a8c3d9
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q92185
is encoded by: hsa:6489
name: ST8SIA1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_23176979_4bb6_4142_8310_bb96390e8b91
has only substance units: false
is encoded by: hsa:64064
name: OXCT2
initial concentration: NaN
boundary condition: true
constant: false
is: Q9BYC2
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_8716861d_e2b2_4a0f_9d22_fe4e8b936caf
constant: false
initial concentration: NaN
is: P48448
name: ALDH3B2
has only substance units: false
type: Species
is encoded by: hsa:222
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR DUTPDP
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: Confidence Level: 3 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: dUTP diphosphatase
is described by: ECO:0000134
reversible: false
is: SBO:0000176
fast: false
type: Reaction

metaR RE3626M
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
name: RE3626
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_ff5144e2_0e1f_44bc_927c_ee28f99dad67
initial concentration: NaN
is encoded by: hsa:6576
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: D9HTE9
type: Species
name: SLC25A1
boundary condition: true
constant: false

metaR r2195
reactant: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is: SBO:0000185
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_71fc1147_70a0_4460_b6a2_825bad76c8e4
name: AKR1A1
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:10327
is: P14550
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM cs e deg7 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
is: CHEBI:15936
initial concentration: 1.0
constant: false
notes: FORMULA: C23H35O27S2 CHARGE: -3
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaR r1116
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
reactant: MODEL1310110033#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185

metaR TTDCAtr
product: MODEL1310110033#
is: SBO:0000185
fast: false
name: tetradecanoate (transport)
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true

metaR BILGLCURtr
product: MODEL1310110033#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
reversible: true
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaM dgtp n
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: dGTP
is: SBO:0000247
is: C00286
initial concentration: 1.0
is: CHEBI:16497
is: HMDB01440
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

metaR FUCFUCGALACGLCGALGLUSIDEte
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
fast: false
name: blood group intracellular transport
is described by: ECO:0000000
product: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_a2f926d5_295d_4554_8dcc_67318c1bd576
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC23A1
is encoded by: hsa:9963

http://identifiers.org/biomodels.db/MODEL1310110033#_b25c3c47_5158_4427_bcf4_e52f63c42ee3
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6547
is: Q96QG2
has only substance units: false
boundary condition: true
name: SLC8A3

metaM hista c
is: HMDB00870
is: CHEBI:58432
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
has only substance units: false
constant: false

metaR PAPStg
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
name: 3'-Phosphoadenylyl sufate Golgi transport
reactant: MODEL1310110033#

metaR S6TASE17ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110033#
is: SBO:0000176
reversible: true
fast: false
modifier: MODEL1310110033#
is described by: ECO:0000000
type: Reaction

metaR r2198
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#

metaM prostge2 c
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: CHEBI:606564
name: prostaglandin E2(1-)
is: HMDB01220

metaR r0801
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
fast: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaM dtdp m
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: C00363
is: HMDB01274
initial concentration: 1.0
is: CHEBI:58369
name: dTDP
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
type: Species
is: SBO:0000247

metaM glc D e
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial concentration: 1.0
is: CHEBI:4167
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB00122

metaR FUCFUCGALACGLCGALGLUSIDEtg
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
kinetic law: MODEL1310110033#
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
fast: false

metaR CYTDt
name: cytidine facilated transport in cytosol
reversible: true
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
product: MODEL1310110033#

metaR r1538
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000185
product: MODEL1310110033#
fast: false
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reactant: MODEL1310110033#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_dc635da2_c77f_4774_8be0_f7b4c71561be
type: Species
is: Q6FHI7
has only substance units: false
initial amount: NaN
name: CA4
boundary condition: true
is: SBO:0000252
is encoded by: hsa:762
constant: false
initial concentration: NaN

metaR GPIMTer U
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
fast: false
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
modifier: MODEL1310110033#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaM alaala e
constant: false
notes: FORMULA: C6H12N2O3 CHARGE: 0
is: HMDB00725
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: D-Alanyl-D-alanine

metaR r0480
is: SBO:0000176
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

metaR P4501B1r
is version of: http://identifiers.org/ec-code/1.14.14.1
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (1545.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:8910454 NOTES:_4 hydroxylation of 17 beta estradiol NJ
is described by: ECO:0000269
name: cytochrome P450 1B1
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110033#
reversible: false

metaR LDH D
is version of: http://identifiers.org/ec-code/1.1.2.4
is described by: ECO:0000304
name: D-lactate dehydrogenase
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
fast: false
reactant: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
is: SBO:0000176

metaR r2197
modifier: MODEL1310110033#
is: SBO:0000185
reversible: true
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM bildglcur e
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: CHEBI:58471
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB03325
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
type: Species
has only substance units: false

metaM Sfglutth c
is: HMDB01550
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: CHEBI:57688
boundary condition: false
constant: false
initial amount: NaN
name: S-formylglutathionate(1-)

metaR O2St
is described by: ECO:0000000
fast: false
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
name: superoxide anion transport via diffusion (extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110033#
reversible: true
is: SBO:0000185

metaR INSTt4
product: MODEL1310110033#
is described by: ECO:0000269
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
type: Reaction
reactant: MODEL1310110033#
name: inositol transport via sodium symport
reversible: true
is: SBO:0000185
modifier: MODEL1310110033#
fast: false

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR HXPRT
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
type: Reaction
reactant: MODEL1310110033#
reversible: false
is described by: ECO:0000269

metaR RE0944E
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0944
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false

metaR r0483
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reversible: true
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is described by: ECO:0000000
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_2b3231f8_613c_42c9_a2e4_31aa0cbd981d
is: P49753
has only substance units: false
is: SBO:0000252
name: ACOT2
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:10965
constant: false

metaM pro D e
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:16313
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: HMDB03411
has only substance units: false
name: D-proline

http://identifiers.org/biomodels.db/MODEL1310110033#_f3daf35f_8e76_48c6_afb0_d7e82c6229f2
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:43
initial concentration: NaN
name: ACHE
constant: false
is: P22303
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_02806ccb_b4bb_4109_842b_588dc15f4c29
is encoded by: hsa:4830
boundary condition: true
constant: false
is: SBO:0000297
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: NME1:NME2

metaM prostge2 e
has only substance units: false
type: Species
is: CHEBI:606564
is: HMDB01220
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: prostaglandin E2(1-)
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_048f0477_c214_437f_bd87_2244889227d1
is encoded by: hsa:10999
boundary condition: true
is: Q6P1M0
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: SLC27A4
constant: false
initial amount: NaN

metaR PItx
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110033#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: Phosphate transporter, peroxisome
is: SBO:0000185
type: Reaction

metaR DHCRD1
name: dihydroceramide desaturase
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ

metaM glc D c
initial amount: NaN
is: HMDB00122
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:4167
type: Species
is: SBO:0000247
name: D-glucose
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaM ditp c
initial concentration: 1.0
is: HMDB03537
is: SBO:0000247
type: Species
constant: false
is: CHEBI:61382
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
boundary condition: false
initial amount: NaN
has only substance units: false

metaR PIt8
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
is: SBO:0000185
fast: false
is described by: ECO:0000006
modifier: MODEL1310110033#
reversible: true
type: Reaction
name: phosphate transport in/out via Na+ symporter
kinetic law: MODEL1310110033#

metaR PIt7
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
type: Reaction
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
fast: false
name: phosphate transport in/out via three Na+ symporter
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

metaR r2199
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
reversible: true
is: SBO:0000185

metaR FTHFL
modifier: MODEL1310110033#
is described by: ECO:0000134
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.5.1.5
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110033#
name: Formate-tetrahydrofolate ligase
is: SBO:0000176

metaM btn m
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00030
constant: false
is: CHEBI:57586
is: SBO:0000247
name: biotinate
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
boundary condition: false
initial concentration: 1.0

metaM bildglcur c
initial amount: NaN
name: bis(beta-glucosyluronate)bilirubin
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
constant: false
is: HMDB03325
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:58471
boundary condition: false

metaR NADtx
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
reversible: true
name: transport of NAD into peroxisome
product: MODEL1310110033#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_18b4a8a5_4ee0_4b0c_94ed_55e50e55c53a
type: Species
has only substance units: false
is: A1L4Q0
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: DGKE
is encoded by: hsa:8526
initial concentration: NaN

metaM mi34p c
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
boundary condition: false
is: SBO:0000247
is: HMDB06235
constant: false
is: CHEBI:28858
name: 1D-myo-Inositol 3,4-bisphosphate

metaM tyr L e
name: L-tyrosine
boundary condition: false
is: HMDB00158
initial concentration: 1.0
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17895
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_c132f34e_b8e7_4e25_a277_95a1613a300e
name: TXNRD1
is encoded by: hsa:7296
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_4bd5860a_5f46_4a6b_9fc8_8d146266d100
boundary condition: true
has only substance units: false
constant: false
is: Q86VV3
is: SBO:0000252
name: ENTPD1
type: Species
is encoded by: hsa:953
initial concentration: NaN
initial amount: NaN

metaR RE2974N
reversible: true
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: RE2974
reactant: MODEL1310110033#
fast: false
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:

metaR APAT2rm
is: SBO:0000176
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
is version of: http://identifiers.org/ec-code/2.6.1.19

http://identifiers.org/biomodels.db/MODEL1310110033#_bb8cbd30_11f6_4cf1_8a4e_52fbc8376de8
initial amount: NaN
name: ST6GALNAC2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:10610
constant: false
is: Q9UJ37

http://identifiers.org/biomodels.db/MODEL1310110033#_cb035312_5b53_4b78_b388_41f84728101c
constant: false
has only substance units: false
type: Species
is: Q8WUX1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:92745
name: SLC38A5
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_d9cf6afe_e4ca_4d00_96e7_c6b242c5df10
is: Q6IBA0
constant: false
initial amount: NaN
is encoded by: hsa:4725
name: NDUFS5
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM 3mox4hpac m
is: HMDB05175
has only substance units: false
is: CHEBI:28111
constant: false
initial concentration: 1.0
boundary condition: false
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
initial amount: NaN
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_4f3878fa_a766_43a4_8f59_08bc97b33f67
is: Q9BZX2
has only substance units: false
initial amount: NaN
is encoded by: hsa:7371
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: UCK2

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_3d08cd54_507e_4b23_93dc_3a71fedd3fd1
initial amount: NaN
name: SLC8A3
boundary condition: true
is: SBO:0000252
type: Species
is: B3KU59
is encoded by: hsa:6547
constant: false
initial concentration: NaN
has only substance units: false

metaM dcmp n
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: SBO:0000247
name: dCMP(2-)
is: CHEBI:57566
boundary condition: false
initial amount: NaN

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM hista e
is: CHEBI:58432
initial amount: NaN
has only substance units: false
is: HMDB00870
name: histamium
boundary condition: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_1505574f_08c0_403e_a9c2_58980385ff2d
boundary condition: true
initial amount: NaN
type: Species
name: PKM2
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: P14618
is encoded by: hsa:5315

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM mi1p D c
name: 1D-myo-inositol 1-phosphate(2-)
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB02985
is: CHEBI:58433
type: Species
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698

metaR RE1254C
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
name: RE1254
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110033#
fast: false

metaR GALASE16ly
name: beta-galactosidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_bcaaefc3_c3fe_4701_aaee_7b802992a1b8
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: O15254
initial amount: NaN
name: ACOX3
is encoded by: hsa:8310
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_b715bbe7_46ae_41e1_a01f_721a2fdd5c04
is encoded by: hsa:26275
name: HIBCH
is: Q6NVY1
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_3e843f5a_b7c6_4d65_81db_c18fc49726fe
type: Species
name: _T83654_1_e
is encoded by: hsa:T83654
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

metaM oxa m
has only substance units: false
initial amount: NaN
name: oxalate(2-)
boundary condition: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
constant: false
is: HMDB02329
is: CHEBI:30623
initial concentration: 1.0
is: SBO:0000247

metaM dtdp n
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
constant: false
is: CHEBI:58369
initial concentration: 1.0
is: HMDB01274
is: SBO:0000247
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

metaR PPCDC
name: phosphopantothenoylcysteine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.36
is: SBO:0000176
type: Reaction
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
reversible: false
product: MODEL1310110033#

metaR HEXDICOAACBPx
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_428b2b9d_de76_4e95_95d9_ee9b01203a8d
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:NOS2A
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: _NOS2A_1_c

http://identifiers.org/biomodels.db/MODEL1310110033#_ad0492d3_b946_4a53_852a_cd4e6d298337
name: NDUFA4L2
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: Q9NRX3
is encoded by: hsa:56901

metaR NCNt
reactant: MODEL1310110033#
is: SBO:0000185
reversible: true
name: Na+/Ca2+-NH4+ exchange
modifier: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000269
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_df5a107f_29a7_4c07_8812_27f79d94a44c
is encoded by: hsa:3033
initial amount: NaN
initial concentration: NaN
is: Q16836
type: Species
boundary condition: true
has only substance units: false
name: HADH
constant: false
is: SBO:0000252

metaM ocdca c
is: CHEBI:25629
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00827
name: stearate

metaR LDH L
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
modifier: MODEL1310110033#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110033#
is described by: ECO:0000000
name: L-lactate dehydrogenase

metaR ALADGLNexR
name: L-alanine/glutamine reversible exchange
product: MODEL1310110033#
is described by: ECO:0000304
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_5cef772c_2dbe_435d_9c49_e44a9264b030
constant: false
is encoded by: hsa:23556
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O95427
boundary condition: true
initial concentration: NaN
name: PIGN

metaM pnto R c
initial concentration: 1.0
name: (R)-Pantothenate
initial amount: NaN
is: HMDB00210
is: SBO:0000247
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
type: Species
is: CHEBI:7916
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_15cd13fb_9afe_4dec_b43d_932c64b60ece
type: Species
name: NUDT12
is encoded by: hsa:83594
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q9BQG2
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_e0809e4c_defc_4f4c_93d9_8e9b8b9c0002
boundary condition: true
name: TXNRD2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:10587
initial amount: NaN

metaM nrpphr e
type: Species
initial amount: NaN
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: CHEBI:33569
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: Norepinephrine
is: HMDB00216

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaM HC02020 r
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
is: CHEBI:3663
name: Cholesterol-ester-palm
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_b41fef31_9bfe_499d_bb97_4a3a953e90f2
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:8781
initial amount: NaN
type: Species
is: SBO:0000252
name: _8781_1_c
initial concentration: NaN

metaR GLUt2m
reactant: MODEL1310110033#
type: Reaction
name: L-glutamate reversible transport via proton symport, mitochondrial
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000269
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110033#_f8bc07ea_da1b_42ee_a1f3_f2d675b1112c
constant: false
name: SLC4A5
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:57835
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_d868555e_2b8f_4641_a71b_4c1c09c709b4
has only substance units: false
is encoded by: hsa:8574
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: O43488
name: AKR7A2
boundary condition: true
initial concentration: NaN

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

metaR r0165
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
reversible: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
fast: false
product: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_b5aa32f6_76d4_4e94_91f8_429cf537f74d
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: _AA788780_1_c
has only substance units: false
is encoded by: hsa:AA788780
boundary condition: true
initial concentration: NaN

metaR r1544
product: MODEL1310110033#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false

metaR TXA2tr
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110033#
name: thromboxane A2 intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
reversible: true
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#

metaR ARAB Lt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: L-arabinoase extracellular transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
type: Reaction

metaR GLXtp
reversible: true
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110033#
is described by: ECO:0000000
name: glyoxylate transport, peroxisomal
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
product: MODEL1310110033#

metaR BUTt2r
kinetic law: MODEL1310110033#
name: Butyrate transport via proton symport, reversible
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
is: SBO:0000185
modifier: MODEL1310110033#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110033#
reactant: MODEL1310110033#

metaM ocdca e
is: SBO:0000247
has only substance units: false
name: octadecanoate (n-C18:0)
type: Species
is: C01530
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
constant: false
is: HMDB00827
initial concentration: 1.0
is: CHEBI:25629
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_0ee6c507_2277_4c30_8005_229e8e00b7d1
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
name: PIGK
is: Q92643
is encoded by: hsa:10026
is: SBO:0000252

metaM pnto R e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00210
is: SBO:0000247
name: (R)-Pantothenate
constant: false
type: Species
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false

metaR RTOTALt
product: MODEL1310110033#
is: SBO:0000185
name: RTOTAL transport
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000000

metaM nrpphr c
name: Norepinephrine
constant: false
initial amount: NaN
is: CHEBI:33569
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: SBO:0000247
initial concentration: 1.0
is: HMDB00216
type: Species
has only substance units: false
boundary condition: false

metaR DATPtn
is: SBO:0000185
name: dATP diffusion in nucleus
reactant: MODEL1310110033#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#

metaM ksii core4 deg2 l
type: Species
is: CHEBI:12936
constant: false
is: SBO:0000247
is: HMDB00143
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II (core 4-linked), degradation product 2
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_5dae2454_30bc_4994_9d26_75aee0969cac
is: Q9NQ66
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: PLCB1
boundary condition: true
initial amount: NaN
is encoded by: hsa:23236

http://identifiers.org/biomodels.db/MODEL1310110033#_bc511426_ac25_48f9_ad6e_23b7bf236117
is encoded by: hsa:54675
type: Species
is: Q9UJA2
is: SBO:0000252
name: CRLS1
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_cc3cad91_0f9b_454c_9d52_eee3a5346a3d
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10166
name: SLC25A15
is: Q9Y619
type: Species

metaR r0166
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#

metaR CHLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110033#
fast: false
reversible: true
name: choline transport via diffusion (cytosol to mitochondria)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_42c7c2c8_d09a_46ac_b6fb_a6683bc90587
has only substance units: false
is encoded by: hsa:5211
name: PFKL
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q7L2M7

http://identifiers.org/biomodels.db/MODEL1310110033#_eaf50a1c_0a37_4893_8326_cf810b8040ef
constant: false
initial amount: NaN
name: PIP4K2C
is encoded by: hsa:79837
is: B3KQV3
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR GLCMter
kinetic law: MODEL1310110033#
reversible: false
product: MODEL1310110033#
fast: false
name: glucose transport via membrane vesicle
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110033#_6d6710fe_3ac5_40e4_a93b_a0cd803e53fb
has only substance units: false
initial amount: NaN
name: _AI915649_1_c
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AI915649
is: SBO:0000252

metaM crn m
is: CHEBI:16347
is: HMDB00062
name: L-Carnitine
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C00318
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR r0163
reactant: MODEL1310110033#
name: 2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873,PMID:3207422 NOTES:
type: Reaction
product: MODEL1310110033#

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR RE3326M
name: RE3326
reactant: MODEL1310110033#
reversible: true
fast: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
product: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4

http://identifiers.org/biomodels.db/MODEL1310110033#_cf034809_f70e_4b39_889d_728af9844c8c
type: Species
is encoded by: hsa:1103
is: SBO:0000252
has only substance units: false
is: Q6LEN6
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
name: CHAT

metaM gt2 hs g
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:28648
initial concentration: 1.0
boundary condition: false
type: Species
name: GT2
notes: FORMULA: C71H117N5O41FULLRCO CHARGE: -3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_faf4f01b_1c23_4d0e_916f_25d3a9c16976
type: Species
name: HK1
has only substance units: false
is: P78542
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:3098
constant: false
initial concentration: NaN

metaM ach e
is: CHEBI:15355
is: HMDB00895
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial concentration: 1.0
name: acetylcholine
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_d58ab4d1_a2ce_453e_86ca_7a2a36adb08b
is: SBO:0000252
is encoded by: hsa:1808
is: B4DR31
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: DPYSL2
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_d53dd4e8_2e0c_4b6e_8a07_f4e685f1e4c6
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: NDUFB4
is: SBO:0000252
has only substance units: false
is: O95168
is encoded by: hsa:4710
boundary condition: true

metaR ACOX22x
is described by: ECO:0000304
reactant: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
is: SBO:0000176
fast: false
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.17.99.3
reversible: false
name: acyl-Coenzyme A oxidase 2, branched chain

metaM HC01223 m
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: CHEBI:57340
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_5b8bc23a_68df_492d_a2d1_a794e6a5cdbf
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: PLA2G1B
is encoded by: hsa:5319
is: P04054

metaM pro D c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false
initial concentration: 1.0
is: HMDB03411
has only substance units: false
name: D-proline
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16313
initial amount: NaN

metaM dolp U c
is: CHEBI:57683
is: SBO:0000247
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
name: dolichyl phosphate(2-)
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR EX pectintchol LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-taurocholic acid complex
type: Reaction

metaM mlthf m
has only substance units: false
is: C00143
is: CHEBI:15636
is: HMDB01533
initial concentration: 1.0
name: 5,10-Methylenetetrahydrofolate
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143

metaM bilirub e
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
boundary condition: false
is: HMDB00054
constant: false
initial amount: NaN
is: SBO:0000247
name: bilirubin(2-)
has only substance units: false
type: Species
is: CHEBI:57977

http://identifiers.org/biomodels.db/MODEL1310110033#_a036580d_bf0d_492f_9c77_b6fe812e201c
boundary condition: true
is: Q53HM1
is encoded by: hsa:54963
initial amount: NaN
has only substance units: false
name: UCKL1
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_cd7abde3_2fde_4fff_a646_7052cfcf07d6
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q16836
initial concentration: NaN
type: Species
name: HADH
is encoded by: hsa:3033

metaR SUCCt4 2
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
name: succinate transport via sodium symport
is: SBO:0000185
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_809c8f79_5398_4072_92ef_7a2eaea3a86b
name: CYP1B1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: Q16678
is encoded by: hsa:1545
boundary condition: true

metaR r1540
fast: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
product: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_e7fefa43_b462_4af3_b8e8_e1234296d892
type: Species
boundary condition: true
name: PHPT1
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29085
is: Q9P019
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_89a06662_d01d_4073_b658_462ddd0b81bc
boundary condition: true
is: P49189
constant: false
type: Species
is encoded by: hsa:223
initial amount: NaN
is: SBO:0000252
name: ALDH9A1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_cc3d8e46_b9b2_4b8c_bdf1_0f5fa0f137bb
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:18
constant: false
has only substance units: false
boundary condition: true
name: ABAT
is: P80404

metaM CE0785 m
is: CHEBI:57795
name: cis,cis-myristo-5,8-dienoyl-CoA
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
type: Species

metaM adn c
initial concentration: 1.0
is: C00212
is: SBO:0000247
boundary condition: false
name: Adenosine
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: CHEBI:16335
type: Species
is: HMDB00050

metaR MAGt
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
type: Reaction
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
name: monoacylglycerol 2 transport
fast: false
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_22222e4b_ad2d_4c23_8409_37d18c6809ca
is: Q9NS82
type: Species
constant: false
name: SLC7A10
is encoded by: hsa:56301
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_3f945788_15de_47bc_a897_5bf1d633d525
has only substance units: false
is: SBO:0000252
is encoded by: hsa:93034
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q96P26
name: NT5C1B
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_54476fa2_193e_4b61_b97b_9e3867ff1c15
initial concentration: NaN
type: Species
boundary condition: true
name: _AI539321_1_c
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:AI539321

metaM ach c
constant: false
boundary condition: false
is: CHEBI:15355
type: Species
is: HMDB00895
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: acetylcholine

http://identifiers.org/biomodels.db/MODEL1310110033#_47d56f0b_e4cb_4493_baed_9cefad05e975
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q8N3E9
is encoded by: hsa:113026
has only substance units: false
initial amount: NaN
name: PLCD3
boundary condition: true

metaM bilirub c
initial concentration: 1.0
boundary condition: false
is: HMDB00054
constant: false
initial amount: NaN
name: bilirubin(2-)
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

metaM CE2839 e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: C01936
name: maltodecaose
constant: false
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
initial amount: NaN
type: Species

metaR RE2974C
type: Reaction
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.149
is: SBO:0000176
reversible: true
is described by: ECO:0000000
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.68
fast: false
name: RE2974
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
kinetic law: MODEL1310110033#

metaR DNDPt34m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110033#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
name: dGDP transport via dTDP antiport
type: Reaction
is described by: ECO:0000269

metaM oxa c
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
is: CHEBI:30623
boundary condition: false
is: HMDB02329
is: SBO:0000247
name: oxalate(2-)
initial concentration: 1.0

metaM tym c
type: Species
is: CHEBI:327995
is: HMDB00306
boundary condition: false
initial concentration: 1.0
name: tyraminium
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483

http://identifiers.org/biomodels.db/MODEL1310110033#_dacf5ecb_e3d6_4303_b189_5efa0191d72f
is: SBO:0000252
type: Species
boundary condition: true
name: HGD
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:3081
is: Q93099
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_f4fbe224_1abd_4e5a_824d_3403c365c3bb
is encoded by: hsa:2879
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: P36969
has only substance units: false
initial concentration: NaN
name: GPX4

http://identifiers.org/biomodels.db/MODEL1310110033#_2ed5e3c9_8f7f_4de7_8cab_9abf889bfa38
has only substance units: false
boundary condition: true
constant: false
name: PLCZ1
type: Species
is: SBO:0000252
is encoded by: hsa:89869
is: Q86YW0
initial concentration: NaN
initial amount: NaN

metaM HC02203 c
has only substance units: false
name: prostaglandin-a2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
is: CHEBI:27820
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_826813b9_af61_4e18_a58f_2374851881c7
is encoded by: hsa:767
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P35219
boundary condition: true
constant: false
name: CA8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_3b930122_ec32_4591_b5d2_449380e9bffa
boundary condition: true
is: P07741
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:353
type: Species
has only substance units: false
name: APRT
initial amount: NaN

metaR LNLCCPT2
reactant: MODEL1310110033#
is: SBO:0000176
name: carnitine transferase
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110033#_4a42fe37_5360_48df_8e8d_bb868d92466a
constant: false
name: PECR
type: Species
is: Q9BY49
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:55825
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_3e7d322f_185f_49c3_a395_ad166e25fc24
is encoded by: hsa:6549
name: SLC9A2
is: Q9UBY0
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_9a634c78_4a33_4a4e_8d43_072eb7fcb8c2
constant: false
is: O95169
type: Species
name: NDUFB8
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4714
is: SBO:0000252
has only substance units: false

metaR SUCOAS1m
modifier: MODEL1310110033#
fast: false
name: Succinate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110033#
is: SBO:0000176
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF

metaM bilirub r
constant: false
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
name: bilirubin(2-)
initial amount: NaN
is: HMDB00054
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_08d0d1dd_d31e_4d20_a857_57a446772018
constant: false
initial concentration: NaN
type: Species
is: B2R6S5
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: CMPK1
is encoded by: hsa:51727

metaR q10tm
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110033#
name: transport of ubiquinone into mitochondria
reactant: MODEL1310110033#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110033#
is: SBO:0000185

metaR r0055
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.7
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is: SBO:0000176

metaR GLYt7 211 r
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
modifier: MODEL1310110033#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: glycine reversible transport via sodium and chloride symport (2:1:1)

metaR LNLCCPT1
type: Reaction
modifier: MODEL1310110033#
fast: false
reversible: false
name: carnitine O-palmitoyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR PI45P3K
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
kinetic law: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.1
name: phosphatidylinositol 4,5-bisphosphate 3-kinase

http://identifiers.org/biomodels.db/MODEL1310110033#_ac17d32a_b6cc_4aba_95b3_3cff48508548
is encoded by: hsa:10599
constant: false
initial concentration: NaN
is: Q9Y6L6
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLCO1B1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_b4d76abc_a4d3_4774_ac92_ba42e3f14851
is encoded by: hsa:1644
has only substance units: false
name: DDC
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q53Y41
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_554b6595_080e_4c1c_8fcd_39e23360bfa3
has only substance units: false
name: BDH1
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:622

metaM crn c
has only substance units: false
is: HMDB00062
type: Species
is: SBO:0000247
is: C00318
boundary condition: false
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
initial amount: NaN
name: L-Carnitine
initial concentration: 1.0

metaM HC02203 e
is: CHEBI:27820
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: prostaglandin-a2
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953

metaM HC01376 m
is: SBO:0000247
name: S-(2-Methylbutanoyl)-dihydrolipoamide
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: CHEBI:28692

metaM ach n
boundary condition: false
is: CHEBI:15355
has only substance units: false
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: acetylcholine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_09803f40_ac0b_4591_a38d_7b995f4ac04c
constant: false
type: Species
name: SLC26A6
is encoded by: hsa:65010
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9NQU1

metaR r1431
is: SBO:0000176
reversible: false
fast: false
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_cbaa7c1f_8ebf_4285_88ab_dc5e1f004ff5
has only substance units: false
is: O00462
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4126
type: Species
initial amount: NaN
constant: false
name: MANBA

http://identifiers.org/biomodels.db/MODEL1310110033#_4b66425f_899b_4c34_b41c_095dd901139f
is encoded by: hsa:1376
is: P23786
is: SBO:0000252
initial amount: NaN
name: CPT2
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaR HMGCOASi
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
name: Hydroxymethylglutaryl CoA synthase (ir)
is described by: ECO:0000269
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
product: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
reactant: MODEL1310110033#
fast: false

metaM 3dhguln c
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 3-dehydro-L-gulonate
initial amount: NaN
is: CHEBI:57655
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: HMDB06334
initial concentration: 1.0
type: Species

metaM 4hpro LT e
boundary condition: false
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: trans-4-hydroxy-L-proline
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_edf88c6b_25fa_453a_9c93_3cfd1166a0d3
is: SBO:0000252
type: Species
is: Q9BRB3
is encoded by: hsa:9091
name: PIGQ
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR PSt3
name: phosphatidylserine transport
type: Reaction
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
is: SBO:0000185
fast: false
product: MODEL1310110033#

metaM bildglcur r
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial concentration: 1.0
type: Species
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
is: CHEBI:58471
has only substance units: false
is: HMDB03325

http://identifiers.org/biomodels.db/MODEL1310110033#_00a7ba20_1327_41c9_9b2e_25ac53620dc3
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:50614
is: Q9HCQ5
name: GALNT9
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_a7c01f13_3cbe_4caa_9737_3df8c244f97d
is: Q8IXK2
constant: false
initial amount: NaN
name: GALNT12
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:79695
initial concentration: NaN
has only substance units: false

metaR APOC LYS BTNP
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is: SBO:0000176
name: proteolysis of apoC-Lys-btn
kinetic law: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: false

metaR r1433
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_bbb128eb_02cb_494c_94a9_962c01129cd7
type: Species
constant: false
initial amount: NaN
is: Q96KJ9
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: COX4I2
boundary condition: true
is encoded by: hsa:84701

http://identifiers.org/biomodels.db/MODEL1310110033#_0078770a_493c_4aa0_a5ec_5a6ecac2f6e8
is: SBO:0000252
is encoded by: hsa:10400
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: Q9UBM1
name: PEMT
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_f73b6a74_2b4e_4322_8f41_5e826a4a8d90
is encoded by: hsa:5728
boundary condition: true
name: PTEN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: F6KD01

metaR CYTK1m
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is: SBO:0000176
name: cytidylate kinase (CMP),mitochondrial
is described by: ECO:0000134

metaM crn e
name: L-Carnitine
has only substance units: false
initial concentration: 1.0
is: C00318
is: SBO:0000247
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00062
type: Species

metaM co e
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
has only substance units: false
type: Species
is: CHEBI:17245
name: carbon monoxide
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01361
initial concentration: 1.0

metaR H2O2t
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
reversible: true
name: hydrogen peroxide transport via diffusion
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000185

metaR r1109
type: Reaction
is: SBO:0000176
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_4d63c0fe_4cff_4a97_940b_5d87ead8b361
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: Q9NYR8
is encoded by: hsa:50700
name: RDH8

metaR DOLGPP Uer
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
reversible: false
is: SBO:0000176
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaM nmn c
is: C00455
constant: false
is: CHEBI:14649
is: SBO:0000247
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: HMDB00229
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: NMN

metaR TXA2te
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: thromboxane A2 transport

http://identifiers.org/biomodels.db/MODEL1310110033#_c38b993a_091b_479b_88c1_6ce5479b48e1
is encoded by: hsa:6005
name: RHAG
constant: false
is: SBO:0000252
has only substance units: false
is: Q96E98
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaM tre e
name: Trehalose
is: SBO:0000247
is: C01083
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
has only substance units: false
is: CHEBI:16551
initial concentration: 1.0
is: HMDB00975
type: Species
boundary condition: false
constant: false

metaM c6dc x
is: HMDB04047
has only substance units: false
is: C14143
initial concentration: 1.0
initial amount: NaN
type: Species
name: adipoyl carnitine
boundary condition: false
notes: FORMULA: C13H22NO6 CHARGE: -1
is: SBO:0000247
constant: false

metaR CYTK1n
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP),nuclear
product: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110033#

metaR 3MOBte
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110033#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110033#
name: Transport of 3-methyl-2-oxobutanoate
product: MODEL1310110033#

metaR r0267
reactant: MODEL1310110033#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.9
reversible: true
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
product: MODEL1310110033#
modifier: MODEL1310110033#

metaR RE1810M
reactant: MODEL1310110033#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
name: RE1810
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
is described by: ECO:0000000

metaR DGCHOLte
name: bile acid intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#

metaR r0268
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.2
fast: false
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
type: Reaction

metaM co c
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
type: Species
constant: false
is: CHEBI:17245
name: carbon monoxide
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01361
initial concentration: 1.0
has only substance units: false

metaR CSPG Btly
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
name: chondroitin sulfate B transport, extracellular to lysosome
product: MODEL1310110033#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

metaR GLYCt
fast: false
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
name: glycerol transport via channel
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is described by: ECO:0000000
reversible: true
product: MODEL1310110033#

metaR r1434
name: Transport reaction
is described by: ECO:0000000
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_700d3464_94c3_4875_bf86_d3604c38934c
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ALPPL2
is: P10696
is encoded by: hsa:251
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_63961458_978b_4d7d_b145_0eeffc8d1be4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:55753
name: OGDHL
type: Species
has only substance units: false
is: Q9ULD0

metaR NDP7g
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
product: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: nucleoside-diphosphatase (UDP), Golgi apparatus
is described by: ECO:0000269
modifier: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR GASNASE3ly
modifier: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.26
product: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
kinetic law: MODEL1310110033#
is described by: ECO:0000000
fast: false
type: Reaction
name: glycosylasparaginase, lysosomal
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_dbba2e9a_5fde_4a6d_bfa6_25ecad21afea
name: _AI435857_1_x
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI435857
boundary condition: true
type: Species
constant: false
is: SBO:0000252

metaR LPCOXp
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: false
name: L-pipecolate oxidase, peroxisomal
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.5.3.1
reactant: MODEL1310110033#
type: Reaction

metaR r1418
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110033#_bc326441_756c_4e72_9d30_a970dfdbbffc
boundary condition: true
type: Species
is encoded by: hsa:U37519
name: _U37519_1_m
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR NDPK2
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110033#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:UDP)
is: SBO:0000176
product: MODEL1310110033#
type: Reaction

metaR UDPGLCAter
modifier: MODEL1310110033#
product: MODEL1310110033#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaM ile L m
initial amount: NaN
is: SBO:0000247
is: HMDB00172
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17191
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaM dudp c
name: dUDP
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: SBO:0000247
is: C01346
is: HMDB01000
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:60471

metaR H2Otg
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110033#
fast: false
name: H2O transport, Golgi apparatus
product: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_f18bf83f_05a1_48ad_8426_e6ccaa39a08c
has part: Q9H490
initial amount: NaN
has part: Q969N2
is encoded by: hsa:94005
name: PIGK:PIGU:PIGT:GPAA1:PIGS
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:51604
constant: false
is encoded by: hsa:128869
type: Species
boundary condition: true
is encoded by: hsa:8733
has part: O43292
is encoded by: hsa:10026
has only substance units: false
has part: Q92643
has part: Q8NBL9

metaM HC02206 e
name: prostaglandin C1(1-)
type: Species
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57399
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_c9e271fa_aad7_47a1_a405_fd1f9d8224fc
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI620219
is: SBO:0000252
initial amount: NaN
constant: false
name: _AI620219_1_m

metaR r2055
is: SBO:0000185
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r1898
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
name: Y+LAT2 Utilized transport
modifier: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_b826b961_e19d_4d16_bb92_ff1cfc15f55b
initial concentration: NaN
boundary condition: true
is: P15104
is encoded by: hsa:2752
name: GLUL
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaM 3spyr c
is: CHEBI:57940
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 3-sulfonatopyruvate(2-)
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
is: HMDB04045

metaR NDPK3
reversible: true
product: MODEL1310110033#
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
name: nucleoside-diphosphate kinase (ATP:CDP)
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM bhb e
is: HMDB00011
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:10983
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

metaR RE0926E
reactant: MODEL1310110033#
modifier: MODEL1310110033#
name: RE0926
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
product: MODEL1310110033#

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaM Lcystin c
is: SBO:0000247
type: Species
is: CHEBI:16283
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
name: L-cystine
is: HMDB00192
initial concentration: 1.0
constant: false

metaR r2054
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR SPC HSt
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
product: MODEL1310110033#
name: sphingosylphosphorylcholine transport (diffusion)
reversible: true
type: Reaction
fast: false

metaR RE1521M
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1521

metaR RE3347C
is: SBO:0000176
product: MODEL1310110033#
reversible: true
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
kinetic law: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
name: RE3347

http://identifiers.org/biomodels.db/MODEL1310110033#_4a0a6b6e_1312_48c0_a342_4aa062509770
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:517
initial amount: NaN
has only substance units: false
name: ATP5G2
initial concentration: NaN
constant: false
is: Q06055

metaR r0497
fast: false
product: MODEL1310110033#
type: Reaction
reversible: true
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_6f3c927b_3fc1_45ac_af60_50a45af1a163
constant: false
has only substance units: false
name: _X63359_1_c
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:X63359
boundary condition: true

metaR CYTK5n
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP),nuclear
modifier: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:

metaR ST8SIA55g
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110033#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_e8c9357f_2417_4e91_bd9a_4583023b2598
is encoded by: hsa:2820
initial concentration: NaN
name: GPD2
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
is: P43304
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_1bdd2835_efcf_45c0_bc14_6483dd789d27
is: P54868
has only substance units: false
name: HMGCS2
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:3158
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_98bae13b_8b7f_48fb_bb82_b7ce83cf2764
initial concentration: NaN
is: Q6NSB3
is encoded by: hsa:276
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: AMY1A

metaM trdox m
constant: false
has only substance units: false
is: CHEBI:18191
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: SBO:0000247
initial concentration: 1.0
name: Oxidized thioredoxin

http://identifiers.org/biomodels.db/MODEL1310110033#_03e9762d_6ff1_49b3_b997_fcfe93675108
is encoded by: hsa:7355
boundary condition: true
type: Species
initial amount: NaN
name: SLC35A2
has only substance units: false
initial concentration: NaN
is: P78381
constant: false
is: SBO:0000252

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM bhb c
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
is: HMDB00011
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:10983
constant: false
is: SBO:0000247
name: (R)-3-hydroxybutyrate

metaM gthox c
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
is: C00127
initial amount: NaN
has only substance units: false
is: CHEBI:58297
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Oxidized glutathione

metaR NDPK1
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
name: nucleoside-diphosphate kinase (ATP:GDP)
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110033#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM cspg e e
constant: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
boundary condition: false
is: HMDB00300
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17568
initial amount: NaN
has only substance units: false
is: C00106
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan

http://identifiers.org/biomodels.db/MODEL1310110033#_21ce79ad_762f_40e1_b363_132cafbb19fa
is encoded by: hsa:9091
initial concentration: NaN
is encoded by: hsa:5277
has part: P57054
type: Species
boundary condition: true
is: SBO:0000297
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
has only substance units: false
has part: B2RAU6
is encoded by: hsa:5279
is encoded by: hsa:51227
constant: false

metaR PGLYCt
name: phosphatidylglycerol transport
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_34b8e163_4813_407b_9bae_374bb0e6847c
name: SUOX
boundary condition: true
initial amount: NaN
is: P51687
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:6821

http://identifiers.org/biomodels.db/MODEL1310110033#_482bb3cf_af14_4119_87b9_4a316a4e1a8b
has only substance units: false
constant: false
name: MPST
initial amount: NaN
type: Species
is: SBO:0000252
is: P25325
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4357

http://identifiers.org/biomodels.db/MODEL1310110033#_3d885b57_ffab_4f9d_942c_ec9abbbba66a
is: P04075
type: Species
name: ALDOA
is encoded by: hsa:226
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6a8f37b2_bfd5_4568_92b0_7b5928c8421f
type: Species
initial concentration: NaN
initial amount: NaN
name: HK1
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3098
constant: false
is: B3KXY9

http://identifiers.org/biomodels.db/MODEL1310110033#_a17fb170_79b1_4200_9bc7_9237d3b73c8c
name: IMPDH1
boundary condition: true
is encoded by: hsa:3614
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: C9JV30
constant: false
has only substance units: false

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_62860075_78c3_4466_b4f8_2fad6dade928
has only substance units: false
is: P34059
is encoded by: hsa:2588
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: GALNS
is: SBO:0000252
initial concentration: NaN

metaM trdrd m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:15967
constant: false
initial amount: NaN
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species

metaR 3SPYRSPm
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110033#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
kinetic law: MODEL1310110033#
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_bb557be6_d4fc_447a_a005_517be6a232c8
is: SBO:0000252
is encoded by: hsa:23530
has only substance units: false
boundary condition: true
constant: false
type: Species
name: NNT
initial concentration: NaN
initial amount: NaN

metaR NDPK7
product: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:dCDP)
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_fcc84edb_2e42_4870_b48c_26d228cc678b
has part: P53597
is: SBO:0000297
has only substance units: false
has part: Q96I99
name: SUCLG2:SUCLG1
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:8802
initial amount: NaN
is encoded by: hsa:8801

metaM mercplac c
type: Species
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
initial concentration: 1.0
initial amount: NaN
name: 3-Mercaptolactate
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/8118
is: HMDB02127
has only substance units: false
boundary condition: false
is: C05823

http://identifiers.org/biomodels.db/MODEL1310110033#_50e75754_073c_435a_a83c_c50bafe8cb9d
initial concentration: NaN
initial amount: NaN
constant: false
name: PLCL1
type: Species
is: Q15111
is: SBO:0000252
is encoded by: hsa:5334
boundary condition: true
has only substance units: false

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_355ca654_21b6_449a_a4a3_e9d970c811fe
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
type: Species

metaM crm hs l
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:52639
constant: false
initial amount: NaN
type: Species
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195

metaM 3ohdcoa m
initial amount: NaN
is: HMDB06402
has only substance units: false
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: SBO:0000247
boundary condition: false
name: 3-oxopalmitoyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57349
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_6f61d8ec_7c49_4032_9c76_535064e6f992
is encoded by: hsa:2182
constant: false
is: O60488
has only substance units: false
name: ACSL4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM HC00250 e
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:29919
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false
name: hydrosulfide

metaR NDPK8
modifier: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dADP)
product: MODEL1310110033#
type: Reaction
fast: false

metaM ksii core2 deg3 l
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: keratan sulfate II (core 2-linked), degradation product 3
is: HMDB00143
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:12936

metaM 5HPET c
initial amount: NaN
is: CHEBI:57450
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01193
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
name: 5(S)-HPETE(1-)
type: Species
constant: false

metaM dhbpt c
type: Species
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
name: 6,7-dihydrobiopterin
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00038
is: CHEBI:20680

metaR NDPK9n
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
reversible: true
product: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110033#_54d808f3_520b_4d26_a85d_25de0b1ee09d
name: _NM_013421_1_e
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:NM 013421
has only substance units: false
type: Species
initial concentration: NaN

metaR NDPK4
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP)
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_0f5f9959_0a06_41aa_b711_8aeb3798f55d
has only substance units: false
boundary condition: true
is: Q4FEB3
initial amount: NaN
is: SBO:0000252
name: CMA1
constant: false
is encoded by: hsa:1215
initial concentration: NaN
type: Species

metaM ksi deg13 l
is: SBO:0000247
name: keratan sulfate I, degradation product 13
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57455
initial concentration: 1.0
is: HMDB01354
notes: FORMULA: C174H280N12O150S8 CHARGE: -8

metaM orot e
type: Species
is: CHEBI:30839
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00226
name: orotate
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_d150b90c_196d_42b6_a387_c1e75ec29937
boundary condition: true
is encoded by: hsa:1738
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: P09622
name: DLD
has only substance units: false
initial amount: NaN

metaM pail5p hs c
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
type: Species

metaM thf m
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C00101
initial amount: NaN
is: CHEBI:57453
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: HMDB01846
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
boundary condition: false

metaM glu5sa c
initial amount: NaN
is: C01165
name: L-Glutamate 5-semialdehyde
is: HMDB02104
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:17232
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
boundary condition: false
constant: false
initial concentration: 1.0

metaM pyr m
constant: false
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species
is: SBO:0000247
is: C00022
name: pyruvate
is: CHEBI:15361
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_441326b2_0b94_4fb5_8cb6_4c40dc59ed20
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:7359
name: _7359_1_c

metaR NDPK5
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110033#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dGDP)

http://identifiers.org/biomodels.db/MODEL1310110033#_130cab11_5e86_45f8_b6db_08c04c9bd9a2
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q86V21
constant: false
name: AACS
is encoded by: hsa:65985

metaR ABTArm
type: Reaction
modifier: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
product: MODEL1310110033#
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.6.1.19

metaR FBA2
product: MODEL1310110033#
is described by: ECO:0000304
reactant: MODEL1310110033#
reversible: true
fast: false
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.1.2.13
is: SBO:0000176
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
type: Reaction
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD

metaR PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is: SBO:0000176
name: PTPATe
is described by: ECO:0000134
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
reversible: true
kinetic law: MODEL1310110033#

metaM HC00250 c
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
is: CHEBI:29919
is: SBO:0000247
name: hydrosulfide

metaR PRO Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
type: Reaction
name: D-proline transport, extracellular
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110033#

metaR NDPK6
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110033#
is: SBO:0000176
name: Nucleoside-diphosphate kinase (ATP:dUDP)
product: MODEL1310110033#
modifier: MODEL1310110033#

metaM 3mop c
initial amount: NaN
constant: false
is: CHEBI:28654
is: SBO:0000247
is: HMDB00491
has only substance units: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial concentration: 1.0
name: 3-methyl-2-oxopentanoate
boundary condition: false

metaM pail hs c
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial amount: NaN
is: CHEBI:57880
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR GLYCtm
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: glycerol transport
product: MODEL1310110033#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false
is: SBO:0000185

metaM nadp x
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
is: HMDB00217
is: CHEBI:58349
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM bhb m
initial amount: NaN
boundary condition: false
constant: false
name: (R)-3-hydroxybutyrate
is: HMDB00011
is: CHEBI:10983
type: Species
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
initial concentration: 1.0

metaR RE2973N
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
name: RE2973
notes: GENE_ASSOCIATION: (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaM 3ohdcoa x
is: SBO:0000247
name: 3-oxopalmitoyl-CoA(4-)
is: CHEBI:57349
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB06402
initial amount: NaN
type: Species
has only substance units: false

metaR GCC2cm
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoamide), mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110033#

metaR SLDx
reversible: true
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
name: L-sulfolactate dehydrogenase (NAD+)
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.37
fast: false
is: SBO:0000176
reactant: MODEL1310110033#

metaM dttp m
name: dTTP
is: HMDB01342
initial amount: NaN
is: CHEBI:37568
type: Species
is: C00459
has only substance units: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM prostgh2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
is: HMDB01381
is: SBO:0000247
name: prostaglandin H2(1-)
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57405
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_5aac1c8f_adc8_4d0a_8a98_393f96721704
has only substance units: false
type: Species
is: O00624
boundary condition: true
is: SBO:0000252
name: SLC17A2
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:10246

metaR VALTA
name: valine transaminase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM urate c
is: CHEBI:17775
initial amount: NaN
boundary condition: false
is: HMDB00289
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
name: Urate
is: C00366

metaR FBA
is described by: ECO:0000134
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
reversible: true
type: Reaction
product: MODEL1310110033#
name: fructose-bisphosphate aldolase
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#

metaR TRDRm
kinetic law: MODEL1310110033#
is described by: ECO:0000269
modifier: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
product: MODEL1310110033#
name: thioredoxin reductase (NADPH)
is version of: http://identifiers.org/ec-code/1.8.1.9
is: SBO:0000176
reactant: MODEL1310110033#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_fc011ee9_3d29_4ff8_81f3_7e04e116c33b
has only substance units: false
boundary condition: true
is: Q8NFM4
constant: false
is encoded by: hsa:196883
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: ADCY4

http://identifiers.org/biomodels.db/MODEL1310110033#_3fa781fd_6f0e_43ce_bcbb_9e640d1fd704
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:7498
name: XDH
boundary condition: true
is: P47989
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_dc6a4b31_4484_4207_8f61_171b78d2f4dc
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:38
has only substance units: false
name: ACAT1
initial amount: NaN
is: P24752

http://identifiers.org/biomodels.db/MODEL1310110033#_18543b24_f1fe_41f4_acf0_6652c1dc2b0b
name: B3GALT5
initial amount: NaN
is: Q9Y2C3
has only substance units: false
constant: false
is encoded by: hsa:10317
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_4bdb2030_a435_4af7_adbb_9283aec8668f
type: Species
name: ACSS3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:79611
initial concentration: NaN
initial amount: NaN
is: Q9H6R3
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_63a3122f_1d4d_46f7_95e3_029de37f555c
is encoded by: hsa:3423
has only substance units: false
is: P22304
name: IDS
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_d623b413_2626_4c3d_a9a0_9843ec358fb5
type: Species
constant: false
is encoded by: hsa:522
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
has only substance units: false
is encoded by: hsa:9551
is: SBO:0000297
boundary condition: true
has part: P56134
initial concentration: NaN

metaM pyr c
name: pyruvate
constant: false
is: http://identifiers.org/pubchem.compound/3324
notes: FORMULA: C3H3O3 CHARGE: -1
is: CHEBI:15361
initial concentration: 1.0
is: C00022
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00243

metaR GLYSNAT5tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_90ff50f8_6391_44a4_9327_26c180d9c0b6
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:1582
initial concentration: NaN
is: Q9UNU6
constant: false
name: CYP8B1
boundary condition: true

metaR NDPK9
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
modifier: MODEL1310110033#
name: nucleoside-diphosphate kinase (ATP:IDP)

metaM prostgh2 c
type: Species
name: prostaglandin H2(1-)
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB01381
is: CHEBI:57405
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_2ebddcea_e0da_47ad_a871_acbbb9d3dfd9
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:229
is: SBO:0000252
initial concentration: NaN
is: P05062
boundary condition: true
name: ALDOB

metaR r1569
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR UDPGALtg
modifier: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
is described by: ECO:0000269
product: MODEL1310110033#
is: SBO:0000185
name: UDP-Gal Golgi transport via CMP antiport
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

metaM 3sala c
type: Species
name: 3-Sulfino-L-alanine
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:61085
boundary condition: false
is: C00606
initial amount: NaN
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606

metaR ATP1ter
is described by: ECO:0000000
product: MODEL1310110033#
fast: false
type: Reaction
name: ADP/ATP transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
reversible: true

metaM uacgam g
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: CHEBI:57705
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: HMDB00290
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_1415e1ad_e47a_4330_a343_0b2e76ba50e2
is encoded by: hsa:3030
name: HADHA
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: E9KL44

metaR AMANK
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
reversible: false
name: N-acetyl-D-mannosamine kinase
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
is version of: http://identifiers.org/ec-code/5.1.3.14
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.59
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_1bb1b32b_a0ec_4d70_a27f_b065cd9754d9
is: Q9Y217
initial concentration: NaN
type: Species
name: MTMR6
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:9107
initial amount: NaN

metaM hco3 m
is: HMDB00595
is: SBO:0000247
is: CHEBI:17544
name: Bicarbonate
constant: false
initial concentration: 1.0
is: C00288
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
has only substance units: false

metaR ACOAD8m
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.10
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
type: Reaction
modifier: MODEL1310110033#
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
is: SBO:0000176
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM

metaR LEUKTRB4t
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110033#
reactant: MODEL1310110033#
name: leukotriene B4 transport
reversible: true
type: Reaction
is: SBO:0000185
fast: false

metaR r0191
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.24
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false

metaM crm hs r
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:52639
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_cfad4730_9a97_45aa_940c_fef602442467
name: ALDOC
has only substance units: false
is: SBO:0000252
constant: false
is: P09972
type: Species
is encoded by: hsa:230
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR TTDCAFATPc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR RE0958E
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#
name: RE0958
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_4cbc5ac7_a935_49b2_8cce_93dfe18e823e
has only substance units: false
type: Species
is encoded by: hsa:411
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: ARSB
is: A8K4A0

metaM glu5sa m
is: HMDB02104
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
boundary condition: false
is: CHEBI:17232
name: L-Glutamate 5-semialdehyde
initial amount: NaN
is: C01165
type: Species

metaR PMTCOAtx
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#

metaR TREHe
reversible: false
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.28
is described by: ECO:0000269
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
is: SBO:0000176
name: alpha,alpha-trehalase
fast: false

metaM occoa c
initial amount: NaN
boundary condition: false
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
constant: false
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
is: HMDB01070
has only substance units: false
type: Species
is: CHEBI:57386

http://identifiers.org/biomodels.db/MODEL1310110033#_2e3f4504_cdcd_4a5f_80d6_58ea9604a123
is: SBO:0000252
constant: false
name: PDE1A
has only substance units: false
is: P54750
type: Species
is encoded by: hsa:5136
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR PLA2 2e
reversible: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (5322.1) or (5319.1) or (81579.1) or (64600.1) or (26279.1) or (5320.1) or (8399.1) or (30814.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:10455175,PMID:10681567,PMID:11031251,PMID:11112443,PMID:8300559,PMID:9188469,PMID:9272153,PMID:9886417 NOTES:phosphatidyl choline degradation NJ
is version of: http://identifiers.org/ec-code/3.1.1.4
name: phospholipase A2
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_6ff4157f_e64a_41f8_a188_ccfd4d7cf8bc
is encoded by: hsa:81849
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: ST6GALNAC5
boundary condition: true
is: Q9BVH7
constant: false

metaR r0193
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
fast: false
reversible: true
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_d5e6615b_ef19_416b_bece_d91daebdf2df
type: Species
is encoded by: hsa:491
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: ATP2B2
is: SBO:0000252
initial amount: NaN
is: Q4J699

metaM cspg e l
is: CHEBI:36005
has only substance units: false
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB02183
boundary condition: false
initial amount: NaN
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan

http://identifiers.org/biomodels.db/MODEL1310110033#_c3068ac6_33f4_4b5e_afea_7a2d71895974
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6715
name: SRD5A1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: P18405

metaR r0494
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaR CSBPASEly
product: MODEL1310110033#
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#

metaR r0196
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
modifier: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#

metaR ACNMLr
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110033#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: N-Acetylneuraminate lyase (reversible)
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR

metaM carn c
notes: FORMULA: C9H14N4O3 CHARGE: 0 INCHI: InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
boundary condition: false
constant: false
type: Species
name: carnosine
is: HMDB00033
initial amount: NaN
is: CHEBI:15727
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM 3pg m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
type: Species
is: HMDB00807
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
constant: false
is: CHEBI:58272
boundary condition: false
is: SBO:0000247

metaM urate e
initial amount: NaN
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: SBO:0000247
name: Urate
is: C00366
initial concentration: 1.0
is: HMDB00289
type: Species
constant: false
is: CHEBI:17775
boundary condition: false
has only substance units: false

metaM his L m
constant: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: SBO:0000247
is: HMDB00177
initial concentration: 1.0
type: Species
initial amount: NaN
name: L-histidine
is: CHEBI:15971
boundary condition: false
has only substance units: false

metaM uacgam c
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:57705
initial amount: NaN
has only substance units: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: HMDB00290
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043

http://identifiers.org/biomodels.db/MODEL1310110033#_ce15f4b8_7e59_4020_89b5_386ffca7ab2e
is encoded by: hsa:29988
is: Q9NY64
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: SLC2A8
has only substance units: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR GALASE13ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
reactant: MODEL1310110033#
name: beta-galactosidase, lysosomal
modifier: MODEL1310110033#

metaM 10fthf5glu e
is: CHEBI:58190
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00224
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM dttp n
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP
constant: false
has only substance units: false
is: CHEBI:37568
is: HMDB01342
boundary condition: false
initial concentration: 1.0
is: C00459
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_98940f1a_e58c_4566_b883_82f84fea3415
type: Species
initial concentration: NaN
is encoded by: hsa:1607
has only substance units: false
initial amount: NaN
constant: false
name: DGKB
is: Q9Y6T7
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_40517198_ab65_4e88_8258_977cbfd46b2a
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: A4GALT
type: Species
is: Q9NPC4
is encoded by: hsa:53947

metaR DM Ser Thr ly
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

metaR r1788
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: false
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110033#
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110033#
is: SBO:0000185

metaM Lcystin e
initial concentration: 1.0
is: SBO:0000247
is: HMDB00192
is: CHEBI:16283
boundary condition: false
constant: false
type: Species
name: L-cystine
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

metaR PYAM5POr
fast: false
product: MODEL1310110033#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110033#
name: pyridoxamine 5'-phosphate oxidase
type: Reaction
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.4.3.5
is: SBO:0000176
reactant: MODEL1310110033#

metaM hs deg14 l
initial amount: NaN
constant: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
has only substance units: false
type: Species
is: CHEBI:16126
is: SBO:0000247
boundary condition: false
name: heparan sulfate, degradation product 14
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_1aec3e18_e4a1_4b22_b99b_5ecc631ab0be
has only substance units: false
is: SBO:0000252
is encoded by: hsa:114805
initial concentration: NaN
is: Q8IUC8
name: GALNT13
initial amount: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_5e036d85_975e_4bcb_aedd_02eccbce016e
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:1356
is: P00450
constant: false
is: SBO:0000252
name: CP
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_60f60b3c_9a2d_4470_a918_9690fdc5afc6
has only substance units: false
type: Species
is encoded by: hsa:23169
is: Q9NTN3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: SLC35D1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_1ac882a7_a306_49ab_82fc_95d5efdf5085
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: FOLR1
initial concentration: NaN
is encoded by: hsa:2348

http://identifiers.org/biomodels.db/MODEL1310110033#_8aa41c64_b890_472a_886d_1230773741b9
constant: false
is: O00330
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8050
initial amount: NaN
has only substance units: false
name: PDHX
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_810e8e33_ed30_4836_b022_26194c599d2e
initial concentration: NaN
name: COX7A2
has only substance units: false
initial amount: NaN
is encoded by: hsa:1347
constant: false
is: SBO:0000252
type: Species
is: H0UI06
boundary condition: true

metaM pyr e
is: HMDB00243
is: SBO:0000247
constant: false
is: CHEBI:15361
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM CE5132 c
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57923
type: Species
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132

http://identifiers.org/biomodels.db/MODEL1310110033#_46d6b4c7_b9aa_4ca4_ade4_7a6a0787346f
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is: Q15067
initial concentration: NaN
name: ACOX1
is encoded by: hsa:51
initial amount: NaN
boundary condition: true

metaR r1576
reversible: true
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000185

metaM 3mop m
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
type: Species
boundary condition: false
initial amount: NaN
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
constant: false
is: CHEBI:28654
has only substance units: false
is: HMDB00491

metaM alaala c
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: D-Alanyl-D-alanine
is: HMDB00725
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H12N2O3 CHARGE: 0

metaR RETt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: Retinol transport via faciliated diffusion
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110033#

metaM hco3 c
boundary condition: false
is: CHEBI:17544
is: C00288
initial concentration: 1.0
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
constant: false
has only substance units: false
name: Bicarbonate
is: SBO:0000247
initial amount: NaN
is: HMDB00595

metaR APOCFm
fast: false
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
type: Reaction
reactant: MODEL1310110033#
reversible: false
name: Apocarboxylase formation, mitochondrial
kinetic law: MODEL1310110033#

metaR CYSGLUexR
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: L-cysteine/L-glutamine reversible exchanger
modifier: MODEL1310110033#
product: MODEL1310110033#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
is: SBO:0000185

metaR UMPK3
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: UMP kinase (UTP)
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaM gpi hs r
has only substance units: false
is: SBO:0000247
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
constant: false
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: CHEBI:16038
initial concentration: 1.0
type: Species
initial amount: NaN

metaM fum c
name: Fumarate
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:29806
is: HMDB00134
constant: false
initial concentration: 1.0
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial amount: NaN
is: C00122
boundary condition: false

metaM gp1calpha hs e
is: HMDB01397
constant: false
is: CHEBI:58115
is: SBO:0000247
type: Species
name: GP1c alpha
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR DNDPt22m
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
name: dTDP transport via dUDP antiport
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_be939489_0c9b_4c8e_9d32_2dc5293cbb04
name: _AV713053_1_m
type: Species
is: SBO:0000252
is encoded by: hsa:AV713053
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaR r1797
product: MODEL1310110033#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110033#

metaR r0908
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reactant: MODEL1310110033#
reversible: true
is: SBO:0000185
type: Reaction
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_874a20d9_250f_4c5f_b8cc_2ba520c236ca
initial amount: NaN
name: SULT1A2
is encoded by: hsa:6799
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_aa209fcb_810e_4dfd_a048_b366e5d23c27
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:200010
is: SBO:0000252
name: SLC5A9
is: E9PAK4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_2e12457e_6a0e_4c79_920d_7279e4fd947a
has only substance units: false
is: Q8TE04
constant: false
is encoded by: hsa:53354
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: PANK1

metaR r1575
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR UMPK4
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
name: UMP kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#

metaR NTD1
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: false
modifier: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
name: 5'-nucleotidase (dUMP)
product: MODEL1310110033#

metaR SUCD1m
name: succinate dehydrogenase
reversible: true
product: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.3.5.1
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
fast: false
type: Reaction

metaM hco3 e
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
has only substance units: false
is: C00288
name: Bicarbonate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:17544
constant: false
type: Species
is: SBO:0000247

metaM mthgxl c
is: CHEBI:17158
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
name: methylglyoxal
is: SBO:0000247
is: HMDB01167
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546

metaR DOPAtu
modifier: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
name: Dopamine uniport
is described by: ECO:0000269
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
type: Reaction
fast: false

metaR UAGDP
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.23
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
type: Reaction
name: UDP-N-acetylglucosamine diphosphorylase
reactant: MODEL1310110033#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110033#
product: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#

metaR r1574
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110033#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

metaM coa c
is: SBO:0000247
is: CHEBI:3312
is: HMDB01423
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
constant: false
is: C00010
type: Species
name: Coenzyme A

metaM dhf c
name: 7,8-Dihydrofolate
constant: false
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: C00415
is: HMDB01056
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM leuktrD4 c
name: Leukotriene D4
is: HMDB03080
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: CHEBI:28666

metaM gp1calpha hs g
initial concentration: 1.0
has only substance units: false
constant: false
is: C00213
is: CHEBI:3513
is: SBO:0000247
type: Species
initial amount: NaN
name: GP1c alpha
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
is: HMDB00271
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_0bd385f9_594c_431d_a7a4_a630f6407e6a
is encoded by: hsa:5277
initial amount: NaN
is: B3KUV7
name: PIGA
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaR NCKt
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
is described by: ECO:0000269
fast: false
type: Reaction
name: Na+/Ca2+-K+ exchange
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaM trdrd c
initial concentration: 1.0
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
name: Reduced thioredoxin
initial amount: NaN
is: CHEBI:15967
boundary condition: false
is: C00342
constant: false
has only substance units: false
is: SBO:0000247

metaM nadp m
name: Nicotinamide adenine dinucleotide phosphate
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:58349
is: C00006
is: HMDB00217
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

http://identifiers.org/biomodels.db/MODEL1310110033#_3937334c_6929_4986_aa49_55dbc71320dd
initial amount: NaN
name: DHCR24
has only substance units: false
type: Species
constant: false
is: Q15392
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1718
is: SBO:0000252

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaM pail hs n
type: Species
is: CHEBI:57880
constant: false
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0
initial amount: NaN

metaM 34hpp e
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
type: Species
boundary condition: false
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_eb77f039_8f00_4a3e_9348_95052bc35c6d
is encoded by: hsa:51109
boundary condition: true
name: RDH11
is: SBO:0000252
type: Species
constant: false
is: B4DDW0
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r1573
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_01f146a4_3f4c_44da_86f7_39d9ef5a119c
is: Q02218
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: OGDH
is encoded by: hsa:4967
is: SBO:0000252

metaR UMPK2
is described by: ECO:0000269
name: UMP kinase (CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
reversible: true
fast: false
modifier: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM xoltetrol c
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: CHEBI:17278
is: HMDB01231
has only substance units: false

metaR GLCNACASE5ly
name: alpha-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_10ec5000_89a6_4fc5_8b44_5b0d973c9e1b
is encoded by: hsa:92483
type: Species
boundary condition: true
constant: false
name: LDHAL6B
initial amount: NaN
has only substance units: false
is: Q9BYZ2
initial concentration: NaN
is: SBO:0000252

metaR r0276
reversible: true
product: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction

metaM ala L e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: L-alanine
is: HMDB00161
constant: false
initial amount: NaN
is: CHEBI:16977

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaM nadp r
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
is: HMDB00217
type: Species
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
is: C00006
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58349

metaR 34HPPte
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000185
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
type: Reaction
kinetic law: MODEL1310110033#

metaM CE2866 c
is: SBO:0000247
name: 3,3'-diiodo-L-thyronine
notes: FORMULA: C15H13I2NO4 CHARGE: 0 INCHI: InChI=1S/C15H13I2NO4/c16-10-7-9(2-3-13(10)19)22-14-4-1-8(5-11(14)17)6-12(18)15(20)21/h1-5,7,12,19H,6,18H2,(H,20,21)/t12-/m0/s1 EHMN_ABBREVIATION: CE2866
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:45698
initial amount: NaN
initial concentration: 1.0

metaM mthgxl e
constant: false
has only substance units: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: SBO:0000247
is: HMDB01167
boundary condition: false
type: Species
initial concentration: 1.0
name: methylglyoxal
is: CHEBI:17158
initial amount: NaN

metaR UGLCNACtg
name: UDP-GlcNAc Golgi transport via CMP antiport
is described by: ECO:0000269
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reversible: true
is: SBO:0000185
modifier: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
fast: false

metaM leuktrD4 e
boundary condition: false
name: Leukotriene D4
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
constant: false
is: HMDB03080

http://identifiers.org/biomodels.db/MODEL1310110033#_0af2973c_43bd_40b0_b94a_468a00f636ad
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:AL048840
constant: false
is: SBO:0000252
initial concentration: NaN
name: _AL048840_1_c
initial amount: NaN

metaR UMPK7
name: UMP kinase (dGTP)
reversible: true
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#

metaR r0389
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000000
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
fast: false
product: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
type: Reaction

metaR TXASr
is described by: ECO:0000134
reversible: false
name: Thromboxane-A synthase
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.99.5
is: SBO:0000176
reactant: MODEL1310110033#

metaM trdox c
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
boundary condition: false
is: CHEBI:18191
initial concentration: 1.0
name: Oxidized thioredoxin
is: C00343

metaR r1579
fast: false
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185

metaM thr L e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: L-threonine
is: CHEBI:16857
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_88b4caaf_83f6_42cf_ad59_7e5b3a51d5d9
initial amount: NaN
is: Q5JT09
boundary condition: true
initial concentration: NaN
is encoded by: hsa:83549
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: UCK1

metaM dtdp c
type: Species
is: CHEBI:58369
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: C00363
initial concentration: 1.0

metaR SPH1Pte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
fast: false
reversible: true
name: sph1p transport
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction

metaM CE5132 n
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
boundary condition: false
is: CHEBI:57923
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
type: Species
has only substance units: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR GLU5SAtmc
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000185
type: Reaction
name: glutamate semi-aldehyde transport, mitochondrial
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
is described by: ECO:0000134

metaM 34hpp c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: HMDB00707
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
is: CHEBI:36242
type: Species

metaM ala L c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: L-alanine
type: Species
is: HMDB00161
has only substance units: false
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
is: CHEBI:16977

metaM HC01434 x
is: SBO:0000247
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
boundary condition: false
is: CHEBI:58931
type: Species
constant: false
name: oxalatosuccinate(3-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR HMGLm
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.1.3.4
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
name: hydroxymethylglutaryl-CoA lyase
type: Reaction

metaR r1578
reactant: MODEL1310110033#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110033#

metaM xol7ah2 c
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:28047
name: 5beta-cholestane-3alpha,7alpha-diol
initial amount: NaN
boundary condition: false
is: HMDB06893
initial concentration: 1.0
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452

metaR UMPK5
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110033#
type: Reaction
name: UMP kinase (dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_6495ce0e_66d1_43cc_b2b3_4e982f563147
has only substance units: false
is: Q9NWU1
is encoded by: hsa:54995
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: OXSM
constant: false

metaR r0909
is: SBO:0000185
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
name: Transport reaction
reactant: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_c8fde0b1_b1ef_46dc_bdb2_2c9c47207dab
type: Species
constant: false
is encoded by: hsa:8836
is: Q92820
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: GGH

metaR RE0915E
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
type: Reaction
name: RE0915
reversible: true
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17

metaM dtdp e
is: CHEBI:58369
is: HMDB01274
is: SBO:0000247
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
constant: false
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
boundary condition: false
initial concentration: 1.0

metaM thr L c
initial concentration: 1.0
name: L-threonine
is: SBO:0000247
has only substance units: false
is: CHEBI:16857
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: HMDB00167
boundary condition: false
constant: false
type: Species

metaR UMPK6
fast: false
modifier: MODEL1310110033#
is described by: ECO:0000269
name: UMP kinase (dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction

metaR GLYCTDle
kinetic law: MODEL1310110033#
name: difussion of glycerol accross the brush border membrane
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is: SBO:0000185

metaM ksi deg15 l
name: keratan sulfate I, degradation product 15
type: Species
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
is: CHEBI:12936
has only substance units: false
is: SBO:0000247

metaR r0388
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
fast: false
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
is described by: ECO:0000000
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
reactant: MODEL1310110033#
is: SBO:0000176

metaM ile L c
is: CHEBI:17191
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: HMDB00172
name: L-isoleucine
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaM no e
boundary condition: false
is: SBO:0000247
constant: false
is: C00533
has only substance units: false
is: CHEBI:16480
is: HMDB03378
initial concentration: 1.0
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
name: Nitric oxide
initial amount: NaN
type: Species

metaM 3mop e
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
initial amount: NaN
type: Species
is: HMDB00491
is: CHEBI:28654
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1

http://identifiers.org/biomodels.db/MODEL1310110033#_6d9b937b_cdbe_4066_ad03_a6a7a37fe4bb
is: Q9BZQ4
constant: false
name: NMNAT2
initial amount: NaN
type: Species
is encoded by: hsa:23057
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR H2Otn
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#
name: H2O transport, nuclear

http://identifiers.org/biomodels.db/MODEL1310110033#_427e37cd_537a_4948_9f26_d037118c1776
name: AK5
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:26289
type: Species
constant: false
boundary condition: true

metaM pail5p hs n
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: CHEBI:57795
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110033#_07585d55_0d41_4160_9253_cdb35a3af651
initial amount: NaN
constant: false
is encoded by: hsa:6817
type: Species
initial concentration: NaN
is: SBO:0000252
name: SULT1A1
boundary condition: true
has only substance units: false

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR r0385
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110033#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110033#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_922a7878_e99d_4122_94ad_9955e0ece134
is: SBO:0000252
boundary condition: true
is encoded by: hsa:493
has only substance units: false
name: ATP2B4
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: P23634

http://identifiers.org/biomodels.db/MODEL1310110033#_14bff901_1973_44f1_950b_b88f55651634
constant: false
is: Q16739
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:7357
has only substance units: false
name: UGCG

metaM ile L e
initial amount: NaN
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:17191
is: SBO:0000247
name: L-isoleucine

http://identifiers.org/biomodels.db/MODEL1310110033#_2c62a786_a743_463e_a913_78eb7176d5ac
name: SLC7A6
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q92536
has only substance units: false
is encoded by: hsa:9057
type: Species
constant: false
is: SBO:0000252

metaM orot c
type: Species
is: C00295
is: CHEBI:30839
name: Orotate
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226
initial amount: NaN

metaR ADK1
product: MODEL1310110033#
is described by: ECO:0000269
name: adenylate kinase
fast: false
reactant: MODEL1310110033#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction

metaM adrn c
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
name: adrenic acid
initial amount: NaN
is: HMDB02226
boundary condition: false
is: SBO:0000247
is: CHEBI:53487

metaM fum m
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB00134
is: C00122
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:29806
is: SBO:0000247
name: Fumarate

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

metaR NTD6
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110033#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reversible: false
name: 5'-nucleotidase (dAMP)

http://identifiers.org/biomodels.db/MODEL1310110033#_66372c3b_8a2a_45e2_a2e0_f274a9ea19c4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3945
boundary condition: true
type: Species
is: SBO:0000252
is: P07195
name: LDHB
constant: false
has only substance units: false

metaR r0386
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#

metaM no c
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
is: C00533
initial concentration: 1.0
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
name: Nitric oxide
boundary condition: false
type: Species

metaR S6TASE3ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110033#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110033#

metaM gdpfuc g
has only substance units: false
is: CHEBI:57984
is: SBO:0000247
is: HMDB01095
name: GDP-L-fucose(2-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

metaR r1421
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Free diffusion
type: Reaction
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_5b75875b_047c_4a61_9443_f20942e4ab76
boundary condition: true
name: HIBADH
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:11112
has only substance units: false
is: P31937

metaR GPIAT
name: glucosaminylphosphatidyl inositol acetyltransferase
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
reactant: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000176
fast: false
product: MODEL1310110033#

metaR NACHEX16ly
modifier: MODEL1310110033#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
fast: false

metaR PSSA1 hs
name: Phosphatidylserine synthase homo sapiens
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.8.29
reversible: true
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
fast: false
is: SBO:0000176

metaR FUT12g
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is described by: ECO:0000269
type: Reaction
name: Galactoside 2-alpha-L-fucosyltransferase 1
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaR H2Otm
modifier: MODEL1310110033#
product: MODEL1310110033#
name: H2O transport, mitochondrial
reactant: MODEL1310110033#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
kinetic law: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000269

metaR ADK3
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
reversible: true
name: adentylate kinase (GTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000269
modifier: MODEL1310110033#

metaR ORETNF
reactant: MODEL1310110033#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: 4-oxo-retinoic acid formation (oxidation)

metaR NTD8
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110033#
reversible: false
name: 5'-nucleotidase (dGMP)
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false

metaM cs a deg2 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: HMDB00127
is: CHEBI:15748
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial concentration: 1.0

metaM crm hs c
initial amount: NaN
name: N-acylsphingosine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: CHEBI:52639

metaM xol7ah2 m
constant: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species
is: HMDB06893
is: CHEBI:28047
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha-diol
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_b04d12a1_1330_449f_8591_30ebfcaa7a82
type: Species
is: SBO:0000252
name: _AI697028_1_m
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI697028
constant: false
initial amount: NaN
boundary condition: true

metaR RE2973C
is: SBO:0000176
is described by: ECO:0000000
name: RE2973
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
product: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110033#

metaR NTD3
modifier: MODEL1310110033#
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (dCMP)
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110033#_28d1a888_75b9_4e18_b9e8_65b6e9635435
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:278
is: P04745
name: AMY1C
boundary condition: true

metaR r0381
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
reactant: MODEL1310110033#
is described by: ECO:0000000
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaM prostgh2 r
name: prostaglandin H2(1-)
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01381
initial amount: NaN
type: Species
is: CHEBI:57405
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

metaM b2coa m
is: HMDB02009
is: CHEBI:57332
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
name: crotonoyl-CoA(4-)
is: SBO:0000247

metaM xoltriol c
initial concentration: 1.0
is: HMDB01457
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
constant: false
boundary condition: false
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: CHEBI:16496
initial amount: NaN
has only substance units: false
type: Species

metaR ASNtN1
reversible: true
name: Asparagine transport (Na, H coupled)
fast: false
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
reactant: MODEL1310110033#
is: SBO:0000185

metaM thym c
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: C00178
constant: false
initial concentration: 1.0
type: Species
is: HMDB00262
name: Thymine
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:17821

http://identifiers.org/biomodels.db/MODEL1310110033#_084cf859_75cf_4d87_820d_9136c104b77c
is encoded by: hsa:4712
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: O95139
name: NDUFB6
is: SBO:0000252
initial amount: NaN
constant: false

metaR XOLEST2te
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:
reactant: MODEL1310110033#
fast: false
is: SBO:0000185
name: cholesterol ester transporter
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reversible: true
type: Reaction

metaR r1571
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
reversible: true

metaM pyr x
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00243
type: Species
is: CHEBI:15361
is: C00022
has only substance units: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247

metaR CYTK4n
fast: false
type: Reaction
name: cytidylate kinase (dCMP,GTP),nuclear
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_ea54c841_89d0_45b2_be3c_a5c04adcac3c
boundary condition: true
constant: false
type: Species
is encoded by: hsa:6536
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P48067
initial amount: NaN
name: SLC6A9

metaR FATP2t
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000269
name: fatty acid electroneutral transport
type: Reaction
fast: false
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185

metaM gt1b hs g
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C77H127N5O46FULLRCO CHARGE: -3
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: GT1b
is: CHEBI:28058

metaR SPHINGStl
product: MODEL1310110033#
reversible: true
type: Reaction
is: SBO:0000185
name: sphingosine intracellular transport
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
is described by: ECO:0000000
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_48fd821d_4fff_4583_a0ec_406909cf8539
initial concentration: NaN
type: Species
name: DGUOK
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1716
is: Q16854
constant: false
is: SBO:0000252

metaR r1570
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR H2Otp
reactant: MODEL1310110033#
name: H2O transport, peroxisomal
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110033#

metaR SERt4
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
name: L-serine via sodium symport
reversible: false
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_f3c74395_ffac_4e39_afb9_4dfb83bb92b3
is: Q6FH11
type: Species
is: SBO:0000252
has only substance units: false
name: HMOX1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3162
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_b56fd914_9c35_4d23_b3e6_29fa991bc180
name: LHPP
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:64077
initial amount: NaN
is: Q9H008
type: Species

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR RE2660N
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000000
name: RE2660
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176

metaR NTD5
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
name: 5'-nucleotidase (dTMP)
type: Reaction
reactant: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110033#
reversible: false

metaM gdpfuc c
is: SBO:0000247
is: CHEBI:57984
initial concentration: 1.0
boundary condition: false
is: HMDB01095
has only substance units: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species
name: GDP-L-fucose(2-)
initial amount: NaN
constant: false

metaM pap g
constant: false
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)
has only substance units: false
type: Species
is: HMDB00061
boundary condition: false
is: SBO:0000247
is: CHEBI:58343
initial amount: NaN
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

http://identifiers.org/biomodels.db/MODEL1310110033#_b2a0d9a6_69e6_4910_b018_b8e0c3ecf5fa
name: ST3GAL2
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:6483
is: Q16842
initial concentration: NaN

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_aa750a39_c3e3_4225_9165_235b7ae4136c
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5167
is: P22413
name: ENPP1
has only substance units: false

metaM HC02206 c
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: SBO:0000247
boundary condition: false
name: prostaglandin C1(1-)
has only substance units: false
type: Species
is: CHEBI:57399
initial amount: NaN

metaR RE2069C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000176
type: Reaction
name: RE2069
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000

metaR DURItn
fast: false
type: Reaction
name: deoxyuridine transport in nucleus
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true
is described by: ECO:0000000

metaM hs deg7 l
name: heparan sulfate, degradation product 7
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: C00032
is: CHEBI:17627
is: HMDB03178
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_a7f53668_8f2e_4d8d_9bc5_ad9dbd1d1201
is: SBO:0000297
has only substance units: false
boundary condition: true
type: Species
has part: P00326
initial concentration: NaN
constant: false
name: ADH1B:ADH1C
initial amount: NaN
is encoded by: hsa:126

metaR ST3GAL22g
reversible: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.99.4
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reactant: MODEL1310110033#
modifier: MODEL1310110033#
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
type: Reaction
fast: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_da8eb524_1b18_44d9_bc0e_7103759e4311
name: VNN3
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:55350
is: SBO:0000252

metaM coa r
name: Coenzyme A
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB01423
is: C00010
boundary condition: false
initial concentration: 1.0
is: CHEBI:57287
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaM CE5161 r
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
constant: false
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57923
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_d1f8bfcc_036f_4e58_9cdc_29a49ee7e87b
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3418
is: P48735
name: IDH2

metaM pap c
boundary condition: false
is: CHEBI:58343
has only substance units: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
constant: false
initial amount: NaN
name: adenosine 3',5'-bismonophosphate(4-)
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB00061

metaM 3aib e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: (S)-3-aminoisobutyric acid
constant: false
is: CHEBI:33094
is: HMDB02166
type: Species
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

metaR CYSSNAT5tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM gpi sig r
boundary condition: false
type: Species
constant: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
notes: FORMULA: Y CHARGE: 0
is: C00459
is: HMDB01342
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:37568
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_60bcb4b3_2fa2_48d6_87c3_a04b3abaa2f8
constant: false
type: Species
has only substance units: false
boundary condition: true
is: B7Z6Q4
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: IMPA1
is encoded by: hsa:3612

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_b8f5aa0b_d6dc_4342_afcd_22c0145b7058
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P21912
type: Species
is encoded by: hsa:6390
has only substance units: false
name: SDHB

metaM aacoa m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: acetoacetyl-CoA(4-)
constant: false
boundary condition: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
type: Species
is: HMDB01484
is: CHEBI:57286

metaR KSII CORE4tly
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
name: keratan sulfate II (core 4) transport, extracellular to lysosome

metaM but e
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: SBO:0000247
is: HMDB00039
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:17968
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_ffdd418d_5a32_4e19_9fde_2c73eee8c29f
type: Species
initial amount: NaN
initial concentration: NaN
name: _AI924226_1_m
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI924226
is: SBO:0000252

metaM cdp n
is: SBO:0000247
name: CDP(3-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
is: HMDB01546
is: CHEBI:58069

metaR r1885
reversible: false
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaR DOLPMT4 Uer
reversible: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#

metaR ARACHDCOAtx
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110033#
name: fatty acid intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110033#

metaR A4GALTg
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is version of: http://identifiers.org/ec-code/2.4.1.228
product: MODEL1310110033#
modifier: MODEL1310110033#
name: Lactosylceramide 4-alpha-galactosyltransferase

metaR r0390
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reactant: MODEL1310110033#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176

metaM occoa x
boundary condition: false
initial amount: NaN
is: HMDB01070
has only substance units: false
constant: false
is: CHEBI:57386
is: C01944
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
initial concentration: 1.0

metaM cit e
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00094
name: citrate(3-)
is: CHEBI:16947
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247
type: Species

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM cdp m
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
is: CHEBI:58069
initial concentration: 1.0
initial amount: NaN
is: HMDB01546
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaR UAG4E
is: SBO:0000176
name: UDP-N-acetylglucosamine 4-epimerase
product: MODEL1310110033#
reversible: true
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/5.1.3.2
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_db989657_49a5_4926_8903_c7405e5da3f5
type: Species
is: E5KSL6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1716
has only substance units: false
initial amount: NaN
name: DGUOK
is: SBO:0000252
constant: false

metaR ACACT1rm
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.9
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/4.2.1.17
name: acetyl-CoA C-acetyltransferase, mitochondrial

metaM glyb c
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial concentration: 1.0
is: CHEBI:17750
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00043
name: glycine betaine

metaM leuktrF4 c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
is: CHEBI:27491
initial amount: NaN
type: Species
boundary condition: false
name: leukotriene F4
is: HMDB06465
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_bc6a6430_19f5_4b61_90ec_b7dd429fad65
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: GLUD1
type: Species
boundary condition: true
initial concentration: NaN
is: E9KL48
constant: false
is encoded by: hsa:2746

metaM HC01434 m
is: SBO:0000247
is: CHEBI:58931
initial concentration: 1.0
name: oxalatosuccinate(3-)
constant: false
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_207c437e_3631_43e6_97bd_161bd9e95209
has only substance units: false
name: PLCB1
is encoded by: hsa:23236
type: Species
boundary condition: true
is: Q9NQ66
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaM adrn e
is: HMDB02226
initial concentration: 1.0
name: adrenic acid
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:53487
boundary condition: false
constant: false

metaR r1400
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
name: Active transport
reactant: MODEL1310110033#
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110033#_c8a952c7_f482_44f1_b90b_460c6d1c92bc
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:518
has only substance units: false
initial concentration: NaN
name: ATP5G3

metaR r2508
kinetic law: MODEL1310110033#
fast: false
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110033#
name: Utilized transport

metaM coa n
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
boundary condition: false
name: coenzyme A(4-)
is: CHEBI:57287
initial amount: NaN
is: HMDB01423

metaR ALAR
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: alanine racemase
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110033#
fast: false
type: Reaction
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_1cfa26c3_a29d_4fd3_a7c3_dc54371119a4
boundary condition: true
constant: false
type: Species
is: Q9NUB1
initial concentration: NaN
is: SBO:0000252
name: ACSS1
is encoded by: hsa:84532
initial amount: NaN
has only substance units: false

metaM ksi deg5 l
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
is: CHEBI:12936
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: HMDB00143
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 5

metaR FAS180COA
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110033#
fast: false
is described by: ECO:0000269
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
name: fatty-acyl-CoA synthase (n-C18:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110033#_31359d29_353d_4799_9c3c_c72da2f6f659
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:114112
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: TXNRD3
is: Q86VQ6

http://identifiers.org/biomodels.db/MODEL1310110033#_f36c9b48_589a_45f1_a340_b0ed321c6ac9
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: P42126
is encoded by: hsa:1632
name: ECI1
type: Species
boundary condition: true
initial concentration: NaN

metaM hs deg13 l
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB03178
is: C00032
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
is: CHEBI:17627
initial amount: NaN
is: SBO:0000247
name: heparan sulfate, degradation product 13

http://identifiers.org/biomodels.db/MODEL1310110033#_a6521663_77fe_4436_8bc0_7d2b542c7b04
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
name: ENTPD3
is encoded by: hsa:956
has only substance units: false
is: O75355
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_4d65ba59_dac3_4791_b6ba_3c499e246fbb
name: _642502_1_c
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:642502

metaM ksii core4 deg4 l
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57455
is: HMDB01354
has only substance units: false
constant: false
notes: FORMULA: C66H108N6O48SX CHARGE: -1
type: Species
initial amount: NaN
name: keratan sulfate II (core 4-linked), degradation product 4

http://identifiers.org/biomodels.db/MODEL1310110033#_7008a352_56ae_438f_9857_8e15622c92c5
constant: false
initial amount: NaN
boundary condition: true
name: GSTZ1
is: SBO:0000252
type: Species
is: O43708
initial concentration: NaN
is encoded by: hsa:2954
has only substance units: false

metaM ha deg1 l
boundary condition: false
has only substance units: false
is: CHEBI:16336
is: SBO:0000247
name: hyaluronan degradation product 1
initial amount: NaN
constant: false
notes: FORMULA: C22H33N2O16 CHARGE: -1
type: Species
initial concentration: 1.0

metaM ksi deg16 l
is: CHEBI:57455
constant: false
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I, degradation product 16
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01354

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM gluside hs g
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
is: CHEBI:18368
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false

metaR H6ET3er
type: Reaction
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
modifier: MODEL1310110033#
reversible: false
fast: false
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.8.1
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD

metaM 7dhf e
name: heptaglutamyl folate (DHF)
is: HMDB06559
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial concentration: 1.0
type: Species

metaM leuktrF4 e
initial amount: NaN
is: HMDB06465
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: CHEBI:27491
name: leukotriene F4

metaR NDPK8n
is described by: ECO:0000304
modifier: MODEL1310110033#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
type: Reaction
fast: false
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR NODe
kinetic law: MODEL1310110033#
is described by: ECO:0000134
name: NODe
is: SBO:0000185
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reversible: true
type: Reaction

metaR BILIRUBt2
type: Reaction
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
name: bilirubin transport via bicarbonate countertransport
product: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
fast: false

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR ARGtm
kinetic law: MODEL1310110033#
name: arginine mitochondrial transport via ornithine carrier
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is: SBO:0000185

metaR F1PGT
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
name: fucose-1-phosphate guanylyltransferase
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
modifier: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.30
reversible: true

metaR LGNCt
name: fatty acid transport via diffusion
reactant: MODEL1310110033#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185

metaR r2506
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_9a691136_7432_4c36_98bf_13fff69bd688
is: SBO:0000252
boundary condition: true
type: Species
name: _T83654_1_m
initial amount: NaN
is encoded by: hsa:T83654
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6bd7f0d1_d085_41e8_b039_39b56433dcfe
boundary condition: true
is: SBO:0000252
is: P52790
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: HK3
initial concentration: NaN
is encoded by: hsa:3101

metaR IMPD
fast: false
name: IMP dehydrogenase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000134
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.205
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:
reversible: false
product: MODEL1310110033#

metaM nadp c
is: CHEBI:58349
is: HMDB00217
constant: false
has only substance units: false
initial concentration: 1.0
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
type: Species
initial amount: NaN

metaR 24 25DHVITD3t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: false
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
name: 24,25-Dihydroxyvitamin D3 transport from cytoplasm
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#

metaM eandrstrn r
is: HMDB00352
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h3,12-16,20-21H,4-10H2,1-2H3/t12-,13+,14-,15-,16+,18-,19-/m0/s1 EHMN_ABBREVIATION: C05139
is: CHEBI:27771
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 16alpha-hydroxydehydroepiandrosterone
initial amount: NaN

metaM 3aib c
initial amount: NaN
is: CHEBI:33094
initial concentration: 1.0
constant: false
name: (S)-3-aminoisobutyric acid
is: HMDB02166
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

http://identifiers.org/biomodels.db/MODEL1310110033#_559fffeb_1682_4106_be8d_0c8156187394
is encoded by: hsa:6532
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: P31645
type: Species
name: SLC6A4
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_d1bab731_e6f2_4795_b454_d18508f75f0a
has only substance units: false
name: PPCS
boundary condition: true
constant: false
is: Q9HAB8
type: Species
is encoded by: hsa:79717
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_4e5b59a5_0d6d_48e9_b2ff_8a03fb604cdf
boundary condition: true
name: SDHA
initial concentration: NaN
constant: false
is encoded by: hsa:6389
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P31040

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_720f7284_7c8b_463f_8f55_499f9e4ff0fa
is: SBO:0000252
is: Q9UHI5
is encoded by: hsa:23428
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: SLC7A8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_05163453_d0d9_4ed3_ad55_bb62489cfafa
type: Species
name: FOLR1
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2348
is: SBO:0000252
constant: false

metaM but c
constant: false
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
is: HMDB00039
boundary condition: false
is: CHEBI:17968
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaM coa m
constant: false
is: C00010
is: HMDB01423
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
boundary condition: false
name: Coenzyme A
is: CHEBI:57287
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_5f14b716_4a95_41d0_b8b5_980805b3deec
initial amount: NaN
is encoded by: hsa:4860
has only substance units: false
type: Species
initial concentration: NaN
name: PNP
boundary condition: true
is: P00491
constant: false
is: SBO:0000252

metaR IMPC
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
type: Reaction
product: MODEL1310110033#
reversible: true
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.3
name: IMP cyclohydrolase

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_43435680_f61d_4252_9a6a_d009a987fb73
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:AA177072
name: _AA177072_1_c
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_03d42bed_f51b_4e47_a706_5d905b513127
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SGMS1
is: SBO:0000252
is: D3DWC4
initial amount: NaN
type: Species
is encoded by: hsa:259230

metaM 5mthf e
is: HMDB01396
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 5-Methyltetrahydrofolate
is: SBO:0000247
constant: false
boundary condition: false
is: C00440
is: CHEBI:3729
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110033#_98cf92b5_c4a6_4ee2_8b36_1ed667eb3c51
is: SBO:0000252
initial amount: NaN
name: PROSC
has only substance units: false
is: O94903
is encoded by: hsa:11212
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR ASNPHELAT2tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM arab L e
is: SBO:0000247
is: CHEBI:30849
type: Species
name: L-arabinose
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0
is: HMDB00646
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_fdbcf703_8dcc_4ac0_b94e_fb742e384455
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1545
name: CYP1B1
is: Q16678

metaM 3aib m
has only substance units: false
initial concentration: 1.0
is: HMDB02166
is: CHEBI:33094
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: (S)-3-aminoisobutyric acid

metaM glygly c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0
name: Glycyl-glycine
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: C02037
is: HMDB11733
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_d4f7bf81_6d0a_4646_8874_f330b4bbcb68
is: SBO:0000252
name: HAGHL
is encoded by: hsa:84264
boundary condition: true
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaR r1557
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110033#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction

metaR MCCCrm
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
type: Reaction
is version of: http://identifiers.org/ec-code/6.4.1.4
is: SBO:0000176
reversible: true
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
name: methylcrotonoyl-CoA carboxylase, mitochondrial
kinetic law: MODEL1310110033#

metaR URIK1
modifier: MODEL1310110033#
reversible: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.48
name: uridine kinase (ATP:Uridine)
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#

metaM gluside hs c
is: CHEBI:18368
type: Species
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
boundary condition: false
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM CE5101 m
is: CHEBI:57795
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
type: Species
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_b9c6ae22_c198_4068_a2c3_ce0ea27c39cf
initial amount: NaN
boundary condition: true
is encoded by: hsa:55312
type: Species
initial concentration: NaN
constant: false
is: B2RDZ2
is: SBO:0000252
name: RFK
has only substance units: false

metaR Q10H2e
name: transport of ubiquinol into lymph
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
fast: false

metaM cdp e
is: HMDB01546
type: Species
is: SBO:0000247
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
initial amount: NaN
name: CDP(3-)
constant: false
has only substance units: false
boundary condition: false

metaR UMPKn
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is: SBO:0000176
name: UMP kinase, nuclear
type: Reaction
reactant: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is described by: ECO:0000269
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_45bd91fd_2f7b_4e35_86fe_5283405a0ef0
name: ACAA2
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10449
constant: false
is: P42765
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_717aa1d6_b655_4efe_b6e2_282336e79001
is: Q8IXW6
initial concentration: NaN
is encoded by: hsa:1809
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: DPYSL3
has only substance units: false

metaM glygly e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0
initial amount: NaN
constant: false
is: HMDB11733
name: Glycyl-glycine
is: C02037
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_d5c61f2e_0ab9_465e_9cf6_f98338a0188b
is: SBO:0000252
constant: false
is: P13196
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:211
has only substance units: false
name: ALAS1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_a2429a48_841a_4bd5_a9d8_d86b255af0c6
has only substance units: false
is: P51178
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5333
name: PLCD1
type: Species
constant: false
initial amount: NaN

metaR FAS80COA L
modifier: MODEL1310110033#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110033#
is described by: ECO:0000269
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
kinetic law: MODEL1310110033#
is: SBO:0000176
type: Reaction
fast: false

metaR r1559
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_b9425492_e89b_49d5_98e8_634c2ac09a4c
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:U37519
has only substance units: false
name: _U37519_1_c
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_876453a2_1cbc_4538_b48d_ad09a32437d7
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q96G03
type: Species
constant: false
is encoded by: hsa:55276
name: PGM2
is: SBO:0000252

metaR HYXNt
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reversible: true
product: MODEL1310110033#
is described by: ECO:0000269
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
name: Hypoxanthine transport

metaM CE2424 m
is: CHEBI:28387
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: SBO:0000247
boundary condition: false
is: HMDB11123
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM aacoa x
name: acetoacetyl-CoA(4-)
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01484
is: SBO:0000247
is: CHEBI:57286
constant: false
initial amount: NaN
boundary condition: false

metaR RE2972M
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.67
is described by: ECO:0000000
name: RE2972
type: Reaction
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_de33d8ea_8979_4b96_9832_94a7e4709598
is: P19961
type: Species
is encoded by: hsa:280
initial concentration: NaN
constant: false
boundary condition: true
name: AMY2B
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r2509
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110033#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110033#
name: Utilized transport
reactant: MODEL1310110033#
reversible: true

metaM 42A3HP24DB c
type: Species
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: C05645
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: HMDB04083
constant: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7956
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM pram c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C03090
is: HMDB01128
has only substance units: false
type: Species
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: CHEBI:58681
boundary condition: false
name: 5-Phospho-beta-D-ribosylamine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_da4a24c6_44f6_4ed6_8a2a_5ee7b4b623a8
constant: false
is encoded by: hsa:23533
has only substance units: false
initial concentration: NaN
is: SBO:0000297
boundary condition: true
initial amount: NaN
type: Species
name: PIK3R5:PIK3CG
has part: Q8WYR1

metaM HC02217 e
constant: false
type: Species
is: CHEBI:27647
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
name: prostaglandin-g2

http://identifiers.org/biomodels.db/MODEL1310110033#_bf49a721_ee58_49cb_aa67_140205521c01
type: Species
name: PIGM
initial amount: NaN
is: SBO:0000252
is: Q9H3S5
is encoded by: hsa:93183
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaM gp1calpha hs c
name: GP1c alpha
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C99H159N7O62FULLRCO CHARGE: -5
initial concentration: 1.0
is: SBO:0000247
is: C00213
is: CHEBI:3513
is: HMDB00271

metaM cit c
is: HMDB00094
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Citrate
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
type: Species
is: CHEBI:16947
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_f7fbef25_23a5_4e7d_8c87_729170f8f721
is: SBO:0000252
name: GALNT7
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: Q86SF2
boundary condition: true
is encoded by: hsa:51809
initial concentration: NaN

metaR GGT6
is: SBO:0000176
name: Gamma-glutamyltransferase
type: Reaction
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
fast: false

metaR NAGA2ly
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.49
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
name: N-acetylgalactosaminidase, alpha-
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false

metaM coa x
is: HMDB01423
is: C00010
is: CHEBI:57287
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
name: Coenzyme A
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false

metaR GALASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
reactant: MODEL1310110033#
is: SBO:0000176
name: beta-galactosidase, lysosomal
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false

metaR RE1522M
type: Reaction
name: RE1522
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM HC02207 e
name: prostaglandin-c2
is: CHEBI:27555
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_1d4241a4_253b_462c_8044_8a8eee0ccfb4
constant: false
boundary condition: true
is: SBO:0000252
name: ATP5F1
is encoded by: hsa:515
initial concentration: NaN
is: Q08ET0
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_08c7be2a_22b1_46d9_889a_6bef52163b98
is encoded by: hsa:8733
constant: false
boundary condition: true
name: GPAA1
initial concentration: NaN
has only substance units: false
is: O43292
is: SBO:0000252
type: Species
initial amount: NaN

metaM ksi deg29 l
name: keratan sulfate I, degradation product 29
has only substance units: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
is: CHEBI:12936
boundary condition: false
constant: false
is: HMDB00143
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_bd045b9d_a74c_4914_80f8_1d71bff7aa9c
constant: false
is: G3XA95
initial concentration: NaN
type: Species
is encoded by: hsa:8611
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PPAP2A
initial amount: NaN

metaM cs b deg1 l
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: HMDB01354
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57455
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR KCCt
fast: false
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: K+-Cl- cotransport
reversible: true
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD

metaM arab L c
is: CHEBI:30849
name: L-arabinose
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0
type: Species

metaR S6TASE19ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
modifier: MODEL1310110033#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000000
reversible: true

metaM HC02217 c
has only substance units: false
type: Species
constant: false
is: CHEBI:27647
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial concentration: 1.0
name: prostaglandin-g2

metaR CHOLK
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110033#
modifier: MODEL1310110033#
name: Choline kinase
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_1daf42b7_ee4b_470b_b174_ea0de87b4c6d
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: B3GALT5
is encoded by: hsa:10317
type: Species

metaM 5mthf c
initial concentration: 1.0
has only substance units: false
is: C00440
type: Species
is: HMDB01396
name: 5-Methyltetrahydrofolate
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: CHEBI:3729
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f26e6dd9_048a_476d_bc5d_9b0c482f7b5c
is encoded by: hsa:5281
name: PIGF
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is: Q07326
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_1ce6511e_6977_410f_bd3c_b9e0ba9c7d0c
is encoded by: hsa:10797
has only substance units: false
is: P13995
boundary condition: true
constant: false
is: SBO:0000252
type: Species
name: MTHFD2
initial amount: NaN
initial concentration: NaN

metaM biliverd c
boundary condition: false
is: CHEBI:57991
name: biliverdin(2-)
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01008

metaM 13 cis retn r
initial concentration: 1.0
is: D00348
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: HMDB06219
initial amount: NaN
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/7847414
has only substance units: false
constant: false
is: SBO:0000247

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR DURIPP
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.2.1
is version of: http://identifiers.org/ec-code/2.4.2.3
reversible: true
modifier: MODEL1310110033#
reactant: MODEL1310110033#
name: deoxyuridine phosphorylase
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
is: SBO:0000176
kinetic law: MODEL1310110033#
fast: false
type: Reaction
is described by: ECO:0000269

metaR r0281
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
type: Reaction
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000176
reversible: true
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/5.3.1.6
product: MODEL1310110033#
is described by: ECO:0000000
fast: false

metaR SIAT9g
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.99.9
type: Reaction
fast: false
is described by: ECO:0000000
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110033#

metaM ddcacoa c
is: HMDB03571
is: CHEBI:57375
initial amount: NaN
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832

metaR HMGLx
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110033#
name: hydroxymethylglutaryl-CoA lyase
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.3.4
is described by: ECO:0000134
reactant: MODEL1310110033#
product: MODEL1310110033#

metaR r0181
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000

metaM HC02207 c
is: CHEBI:27555
constant: false
is: SBO:0000247
has only substance units: false
name: prostaglandin-c2
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
type: Species

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR r0280
modifier: MODEL1310110033#
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_ec718e6b_cf65_4807_8691_136355cc9cac
initial concentration: NaN
initial amount: NaN
is: Q99643
boundary condition: true
type: Species
name: SDHC
is encoded by: hsa:6391
has only substance units: false
is: SBO:0000252
constant: false

metaM odecoa r
has only substance units: false
is: CHEBI:57387
constant: false
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
initial concentration: 1.0
type: Species
name: oleoyl-CoA(4-)
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR THRGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110033#
fast: false
name: L-threonine/glycine reversible exchange
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_56146863_51e4_44cc_b161_61c9e35a8512
initial amount: NaN
is: Q9NR45
has only substance units: false
constant: false
name: NANS
initial concentration: NaN
boundary condition: true
is encoded by: hsa:54187
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_46446a2e_96c1_4bd4_b579_8a82c1d1cd05
is: P09104
name: ENO2
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:2026
initial concentration: NaN

metaR r1562
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000185

metaR ACETONEt2
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: acetone transport via proton symport
product: MODEL1310110033#

metaM C05965 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: SBO:0000247
name: 12(S)-HPETE(1-)
is: HMDB04243
initial amount: NaN
constant: false
is: CHEBI:57444
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_5ad14ba3_d572_4b79_962b_60859093f05e
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6513
is: P11166
name: SLC2A1
constant: false

metaR H2CO3D
type: Reaction
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
is version of: http://identifiers.org/ec-code/4.2.1.1
is described by: ECO:0000000
name: carboxylic acid dissociation
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_3eddcaf5_564d_455c_af92_75c7a890d9a5
initial amount: NaN
is: Q9H6Y6
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: MYO5B
type: Species
constant: false
is encoded by: hsa:4645

metaR r0283
reactant: MODEL1310110033#
type: Reaction
name: L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.6
is: SBO:0000176
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.157
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (AA676725.1) or (196951.1) or (2584.1) or (2585.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 6.3.2.11 Confidence Level: 0 AUTHORS: PMID:448355,PMID:487087 NOTES:
fast: false
reversible: false
is described by: ECO:0000000

metaR PI4PLC
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.4.11
is described by: ECO:0000269
reversible: false
product: MODEL1310110033#
name: phosphatidylinositol 4-phosphate phospholipase C
fast: false

metaR DM Lcystin
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaR KHK
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.3
reversible: false
kinetic law: MODEL1310110033#
name: ketohexokinase
type: Reaction
fast: false
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110033#
is described by: ECO:0000000

metaR ACt2m
reactant: MODEL1310110033#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
name: acetate mitochondrial transport via proton symport
type: Reaction
is described by: ECO:0000000

metaR TRDR
is: SBO:0000176
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110033#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
name: thioredoxin reductase (NADPH)
product: MODEL1310110033#
is described by: ECO:0000269

metaR r1561
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction

metaR CHAT
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
is: SBO:0000176
fast: false
name: Choline O-acetyltransferase
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110033#
modifier: MODEL1310110033#
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.3.1.6

http://identifiers.org/biomodels.db/MODEL1310110033#_599299c0_a236_4ad4_8b2f_fba7555585e4
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: _AI191472_1_c
is encoded by: hsa:AI191472

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_99a366f6_0f5b_4449_bec8_37a2dcda4595
initial amount: NaN
name: MIA3
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: Q5JRA6
has only substance units: false
is encoded by: hsa:375056
type: Species

metaM acglcgalgluside hs g
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
is: CHEBI:17103
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r1564
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110033#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_0864f932_0c87_420f_b1bf_d53108f50ce4
name: IDH2
constant: false
is: P48735
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3418
boundary condition: true
type: Species
has only substance units: false

metaR NAGLCAly
type: Reaction
is: SBO:0000176
product: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110033#
fast: false

metaM 3sala m
has only substance units: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: SBO:0000247
name: 3-sulfino-L-alanine (1-)
is: CHEBI:61085
initial amount: NaN
type: Species
boundary condition: false
is: C00606
initial concentration: 1.0
constant: false

metaM acgal l
type: Species
is: HMDB00212
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:28037
constant: false
name: N-acetyl-D-galactosamine
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial concentration: 1.0

metaM 10fthf7glu e
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:58190
boundary condition: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
name: 10-formyltetrahydrofolate-[Glu](7)
initial amount: NaN
is: HMDB00224

metaM CE2417 m
constant: false
is: SBO:0000247
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
has only substance units: false
is: CHEBI:28387
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: HMDB11123
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_60050a7f_af82_4559_81de_7b29984b28c2
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:126
is: SBO:0000252
type: Species
name: ADH1C
is: P00326
boundary condition: true

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00951
boundary condition: false
type: Species
name: taurochenodeoxycholate
is: SBO:0000247
initial concentration: 1.0

metaR r0186
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:

metaR r1563
reactant: MODEL1310110033#
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false

metaM ddcacoa x
is: CHEBI:57375
initial concentration: 1.0
initial amount: NaN
is: C01832
type: Species
is: HMDB03571
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_37ffa89d_73d9_4690_95d6_8ad0d7b5021c
name: PDXK
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8566
constant: false
is: O00764

metaR URIt5le
is described by: ECO:0000134
name: uridine transport in via sodium symport (1:2)
reversible: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110033#

metaM trp L c
name: L-tryptophan
type: Species
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: SBO:0000247
is: CHEBI:16828
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR ACt2r
name: acetate reversible transport via proton symport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reactant: MODEL1310110033#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false

metaR r1566
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000185
fast: false
reactant: MODEL1310110033#
reversible: true
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR O2t
is: SBO:0000185
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#
name: o2 transport (diffusion)
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD

metaM his L c
is: CHEBI:15971
constant: false
name: L-histidine
type: Species
has only substance units: false
boundary condition: false
is: HMDB00177
initial amount: NaN
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: SBO:0000247
initial concentration: 1.0

metaR r1994
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#

metaR r0399
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110033#
is: SBO:0000176
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_ca2b54ae_8206_4976_96c9_306249109abd
initial amount: NaN
is: SBO:0000252
is: Q9NRA0
is encoded by: hsa:56848
type: Species
initial concentration: NaN
name: SPHK2
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_c12b45d6_c8af_44ed_9c1e_43e3cb70fac0
boundary condition: true
constant: false
is encoded by: hsa:8396
name: PIP4K2B
initial concentration: NaN
has only substance units: false
is: P78356
type: Species
is: SBO:0000252
initial amount: NaN

metaR r1565
kinetic law: MODEL1310110033#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR 3DSPHR
modifier: MODEL1310110033#
name: 3-Dehydrosphinganine reductase
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.102
reversible: false
kinetic law: MODEL1310110033#
is described by: ECO:0000269
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM cdp c
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
initial concentration: 1.0
is: CHEBI:58069
is: C00112
constant: false
is: HMDB01546
has only substance units: false
name: CDP
is: SBO:0000247
type: Species

metaM tdchola e
is: SBO:0000247
name: taurochenodeoxycholate
is: CHEBI:9407
initial concentration: 1.0
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00951
boundary condition: false

metaR r1568
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
reversible: true
product: MODEL1310110033#

metaM occoa m
is: HMDB01070
type: Species
is: CHEBI:57386
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
is: SBO:0000247
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR r1996
kinetic law: MODEL1310110033#
reversible: false
type: Reaction
reactant: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110033#

metaM his L e
type: Species
is: HMDB00177
initial amount: NaN
boundary condition: false
name: L-histidine
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
is: CHEBI:15971

http://identifiers.org/biomodels.db/MODEL1310110033#_880bda48_a27b_464f_ba13_798e3fa82971
name: GLB1
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: P16278
initial concentration: NaN
is encoded by: hsa:2720
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_b6b94a0b_b5ed_44a2_9291_f53d5d4f5867
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:10005
initial amount: NaN
name: ACOT8
is: O14734
type: Species
initial concentration: NaN

metaM aacoa c
name: Acetoacetyl-CoA
is: CHEBI:57286
is: C00332
type: Species
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_3e023437_f0c6_4726_9e56_35b8e02ec99c
initial amount: NaN
is: SBO:0000252
name: _AI971036_1_m
initial concentration: NaN
is encoded by: hsa:AI971036
has only substance units: false
constant: false
type: Species
boundary condition: true

metaR r1567
reversible: true
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR SLDt
name: L-sulfolactate transport (cytosol to extracellular)
reactant: MODEL1310110033#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM
is described by: ECO:0000000

metaR GUAt
modifier: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
type: Reaction
name: Guanine transport
reversible: true
reactant: MODEL1310110033#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110033#
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_748a30f4_17e6_46d0_9d3f_cc489485836c
is encoded by: hsa:217
initial concentration: NaN
type: Species
initial amount: NaN
name: ALDH2
constant: false
has only substance units: false
is: SBO:0000252
is: P05091
boundary condition: true

metaM xol7ah3 m
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
boundary condition: false
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: SBO:0000247
is: CHEBI:28540
is: HMDB12455
type: Species
constant: false
initial amount: NaN

metaM HC00664 c
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: D-tagatofuranose 6-phosphate(2-)
is: SBO:0000247
is: CHEBI:58695

metaR DHFR
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
name: dihydrofolate reductase
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
reversible: true
product: MODEL1310110033#
is: SBO:0000176
kinetic law: MODEL1310110033#

metaR DDPGAm
type: Reaction
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000000
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
is: SBO:0000176
product: MODEL1310110033#
reversible: true

metaM fmn c
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
type: Species
is: HMDB01520
initial amount: NaN
constant: false
initial concentration: 1.0
name: FMN
is: SBO:0000247
is: C00061
is: CHEBI:58210
has only substance units: false
boundary condition: false

metaR LPASE
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.5
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#
name: lysophospholipase
modifier: MODEL1310110033#

metaR CRVNCtr
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#

metaR G5SADs
reversible: false
reactant: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000176
name: L-glutamate 5-semialdehyde dehydratase (spontaneous)
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:Needed in L-proline biosynthesis
kinetic law: MODEL1310110033#
product: MODEL1310110033#

metaM dhcholestancoa x
is: HMDB02159
is: CHEBI:15494
boundary condition: false
constant: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial amount: NaN
has only substance units: false

metaM xoldioloneh c
has only substance units: false
is: HMDB06887
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:2288
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
constant: false

metaR It
is: SBO:0000185
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
name: Iodide uniport
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#

metaM 2425dhvitd3 c
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1 EHMN_ABBREVIATION: CE1337
initial concentration: 1.0
constant: false
is: CHEBI:28818
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
name: (24R)-24,25-dihydroxycalciol
boundary condition: false

metaR OMHPALTD
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_e9c63114_f1d2_440f_bb02_ab212c976db7
initial concentration: NaN
name: DGAT1
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:8694
is: O75907

metaM galacglcgalgluside hs g
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Lc4Cer
is: CHEBI:17103
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
has only substance units: false

metaM gthox m
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
is: SBO:0000247
is: CHEBI:58297
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_fbd56030_1fdd_47b5_ba3e_f869067e32f3
is: P22352
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:2878
has only substance units: false
name: GPX3
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_fb508679_113f_4141_a589_13bf5426a420
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: Q5MY95
is encoded by: hsa:377841
name: ENTPD8
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM gmp g
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB01397
name: GMP(3-)
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
type: Species
is: CHEBI:58115

http://identifiers.org/biomodels.db/MODEL1310110033#_a57df3e4_450f_40d2_bd07_8a574d13eff1
name: SLC16A8
boundary condition: true
is: O95907
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23539
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaR IDOAASE4ly
reversible: false
modifier: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110033#
fast: false
type: Reaction
kinetic law: MODEL1310110033#

metaR PIPLCn
reversible: false
reactant: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
is: SBO:0000176
name: phosphatidylinositol phospholipase C, nucleus
fast: false

metaM ddcacoa m
boundary condition: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: HMDB03571
initial amount: NaN
is: SBO:0000247
is: C01832
type: Species
has only substance units: false
is: CHEBI:57375
name: Dodecanoyl-CoA (n-C12:0CoA)
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6b7a8098_720a_47a6_a01b_bf1c76a61d27
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _AA177072_1_x
is encoded by: hsa:AA177072

metaR DGSNtm
fast: false
name: deoyguanosine transport in mitochondria
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaM acgal c
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00212
name: N-acetyl-D-galactosamine
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:28037

metaM cs a deg5 l
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C23H36O24S CHARGE: -2
is: CHEBI:15936
boundary condition: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
initial concentration: 1.0
has only substance units: false

metaR RETI1
name: retinol isomerase (11-cis)
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110033#
reactant: MODEL1310110033#

metaR CDPDAGtm
type: Reaction
product: MODEL1310110033#
name: intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false
is: SBO:0000185
reversible: true

metaR NDPK7n
is: SBO:0000176
product: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110033#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is described by: ECO:0000304
fast: false

metaM trp L e
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16828
boundary condition: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: HMDB00929
name: L-tryptophan
initial amount: NaN
is: SBO:0000247

metaR RTOTALFATPc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaR NACHEX13ly
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
modifier: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_c56765a9_3bd0_4672_b4c7_25658716e468
has part: Q6IB04
constant: false
is encoded by: hsa:5281
is: SBO:0000297
has only substance units: false
name: PIGF:PIGO
type: Species
boundary condition: true
is encoded by: hsa:84720
initial concentration: NaN
initial amount: NaN

metaR DM gncore2 g
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gncore2(g)
type: Reaction

metaR r0033
is version of: http://identifiers.org/ec-code/3.6.1.5
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reversible: false
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is: SBO:0000176
kinetic law: MODEL1310110033#

metaM cit m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Citrate
type: Species
constant: false
is: HMDB00094
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: SBO:0000247
is: C00158

metaR RE3272N
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110033#
type: Reaction
reversible: true
is described by: ECO:0000000
name: RE3272

metaM 2425dhvitd3 e
initial amount: NaN
is: CHEBI:28818
initial concentration: 1.0
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1 EHMN_ABBREVIATION: CE1337
is: SBO:0000247
type: Species
name: (24R)-24,25-dihydroxycalciol
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_73afbbba_e7bf_4452_9927_d963d49fd6aa
is encoded by: hsa:2184
boundary condition: true
type: Species
is: SBO:0000252
is: P16930
constant: false
initial concentration: NaN
name: FAH
initial amount: NaN
has only substance units: false

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_4183e7d7_4e27_423f_ba39_119c2573e37e
constant: false
is encoded by: hsa:1103
initial concentration: NaN
boundary condition: true
is: Q6LEN5
name: CHAT
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_6fed0750_de7e_4bf8_8338_e30aecf33b97
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:114
constant: false
initial amount: NaN
initial concentration: NaN
is: Q4F7X0
name: ADCY8
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_ee1e3abf_f62a_45bb_a7aa_2c0299728feb
initial amount: NaN
name: _BC005314_1_x
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:BC005314
boundary condition: true

metaM gmp e
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: GMP(3-)
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
has only substance units: false
is: HMDB01397
initial amount: NaN
is: CHEBI:58115

http://identifiers.org/biomodels.db/MODEL1310110033#_5678f93f_9c88_481d_af0b_67f5aadf04b3
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:9374
initial amount: NaN
initial concentration: NaN
is: Q9UMR5
constant: false
name: PPT2

http://identifiers.org/biomodels.db/MODEL1310110033#_09dcab0c_2e40_4ba7_8f87_512f7a3c9a37
has only substance units: false
constant: false
name: HK1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3098
initial amount: NaN
type: Species
is: SBO:0000252
is: Q59FD4

http://identifiers.org/biomodels.db/MODEL1310110033#_22b9ed30_9aa1_41f3_b13f_428e12a624d1
initial amount: NaN
boundary condition: true
name: _AI769281_1_e
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI769281

metaR SRTNt6 2 r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
fast: false
type: Reaction
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
modifier: MODEL1310110033#
is: SBO:0000185

metaR RPEc
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reversible: true
kinetic law: MODEL1310110033#
fast: false
is described by: ECO:0000134
name: ribulose 5-phosphate 3-epimerase
is: SBO:0000176
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction

metaM 5aizc c
is: SBO:0000247
initial concentration: 1.0
is: C04751
initial amount: NaN
constant: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
is: CHEBI:58564
has only substance units: false
type: Species
is: HMDB06273
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_66358941_cfd5_4c4b_9d90_2dabeb45f987
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q8IV97
boundary condition: true
constant: false
type: Species
name: SLC7A5
is: SBO:0000252
is encoded by: hsa:8140

metaR HIBDm
reactant: MODEL1310110033#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is described by: ECO:0000269
product: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.31
modifier: MODEL1310110033#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110033#_9ce9976a_19b4_4572_a4ee_f13f3e218319
type: Species
has only substance units: false
is encoded by: hsa:7498
initial concentration: NaN
initial amount: NaN
is: P47989
constant: false
boundary condition: true
is: SBO:0000252
name: XDH

metaR ACGAMPM
product: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/5.4.2.3
is: SBO:0000176
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
name: phosphoacetylglucosamine mutase
fast: false
is described by: ECO:0000269
reversible: true

metaR r1893
modifier: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#
reversible: false
product: MODEL1310110033#
fast: false
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_16d4f807_f08a_436c_9f4b_f0aba81d3ccb
has only substance units: false
boundary condition: true
is encoded by: hsa:23428
has part: Q86U05
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000297
name: SLC7A8:SLC3A2
constant: false

metaM asp L c
type: Species
name: L-aspartate(1-)
initial concentration: 1.0
boundary condition: false
is: HMDB00191
has only substance units: false
constant: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: SBO:0000247
is: CHEBI:29991
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_62a05b9f_9f07_4261_98e2_7984bd72bc84
constant: false
is: SBO:0000252
initial amount: NaN
name: PIGS
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:94005
is: Q8NBL9

metaR ALAALACNc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: ALAALACNc
type: Reaction

metaR CYTK3n
reversible: true
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
fast: false
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_346ec778_2512_4aac_8e27_441ea7a0a702
is: E7EPT3
is encoded by: hsa:501
boundary condition: true
has only substance units: false
constant: false
name: ALDH7A1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR FACOAL204
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
is: SBO:0000176
product: MODEL1310110033#
fast: false
reversible: true
type: Reaction
name: fatty-acid--CoA ligase
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
kinetic law: MODEL1310110033#

metaM 3m4hpga m
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB04061
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
type: Species
is: http://identifiers.org/pubchem.compound/7909
is: SBO:0000247
is: C05583
initial amount: NaN
constant: false

metaM xol7ah3 c
is: CHEBI:28540
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB12455
name: 5beta-cholestane-3alpha,7alpha,26-triol
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_9c02ebd3_59e0_42b3_a96a_87cfb988095c
boundary condition: true
initial concentration: NaN
constant: false
name: SLC2A6
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9UGQ3
is encoded by: hsa:11182

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaR PPA
type: Reaction
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110033#
reversible: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
name: inorganic diphosphatase

metaM ksi deg7 l
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01354
name: keratan sulfate I, degradation product 7
type: Species
is: CHEBI:57455
constant: false
boundary condition: false

metaR FATP1t
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
is described by: ECO:0000269
reversible: true
name: fatty acid electroneutral transport
type: Reaction
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_9b067829_f76d_482c_afa4_8caabe1f9e85
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
name: DGKZ
boundary condition: true
initial amount: NaN
is: B7Z6M3
is encoded by: hsa:8525
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f78ed721_42f5_4952_b2b6_0dabbec8d1f3
initial concentration: NaN
type: Species
name: HSD3B2
is encoded by: hsa:3284
constant: false
is: SBO:0000252
is: P26439
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_17417f30_5658_4183_b779_4b5fda91ef96
initial concentration: NaN
is encoded by: hsa:56913
name: C1GALT1
is: Q9NS00
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaR r0392
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110033#
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
product: MODEL1310110033#

metaR r1895
is described by: ECO:0000000
reversible: false
fast: false
modifier: MODEL1310110033#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#

metaR S6TASE22ly
kinetic law: MODEL1310110033#
reversible: true
name: galactose-6-sulfate sulfatase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110033#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
product: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176

metaR NACHEX8ly
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110033#
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110033#
reversible: false
type: Reaction

metaR TPI
kinetic law: MODEL1310110033#
fast: false
reversible: true
modifier: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.1
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is described by: ECO:0000134
name: triose-phosphate isomerase
is: SBO:0000176
reactant: MODEL1310110033#

metaR r1560
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_a9e2c6ae_bc74_4a09_a849_0d0bd8118573
boundary condition: true
type: Species
is encoded by: hsa:AA278423
has only substance units: false
initial concentration: NaN
constant: false
name: _AA278423_1_c
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_7120a022_482b_4966_bd40_f5a69c73f325
constant: false
has only substance units: false
is encoded by: hsa:53354
name: PANK1
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q8TE04
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_f3c4d4fa_99e8_4b07_8604_fef9e6cd88cb
constant: false
name: PDE7A
initial amount: NaN
is encoded by: hsa:5150
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_47de7c0f_34cc_4940_a079_294c48381937
name: UPP2
constant: false
is: SBO:0000252
is: O95045
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:151531
boundary condition: true
type: Species

metaR G5SADrm
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
fast: false
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#

metaR r0393
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction

metaM asp L e
name: L-aspartate(1-)
initial concentration: 1.0
boundary condition: false
is: HMDB00191
constant: false
is: SBO:0000247
is: CHEBI:29991
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_da5f9294_5180_48ed_ba2c_76cd494a7721
name: HADHA:HADHB
initial amount: NaN
has part: P55084
has part: E9KL44
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3032
is: SBO:0000297
has only substance units: false
is encoded by: hsa:3030
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_41697392_51d2_4623_915b_8ebe4263db58
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2629
initial concentration: NaN
has only substance units: false
boundary condition: true
name: GBA
is: P04062
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6f9a02cd_6f15_4fe6_9c93_d74613dae551
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _HG2846_HT2983_1_m
is encoded by: hsa:HG2846-HT2983
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_43649aad_c576_4563_928d_e7c48a910e6f
name: NT5C
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:30833
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q8TCD5
initial amount: NaN

metaR GGH 6THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
fast: false
type: Reaction
name: Gamma-glutamyl hydrolase (6THF), extracellular
product: MODEL1310110033#
is described by: ECO:0000000
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#

metaR r0394
reactant: MODEL1310110033#
fast: false
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is: SBO:0000176

metaR ST3GAL23g
is: SBO:0000176
is described by: ECO:0000269
name: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
modifier: MODEL1310110033#
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
fast: false
type: Reaction
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.4.99.4

http://identifiers.org/biomodels.db/MODEL1310110033#_5fd61a8a_134f_4d25_aebc_c5a0a65c5f6c
boundary condition: true
is encoded by: hsa:4846
is: A0S0A7
is: SBO:0000252
has only substance units: false
name: NOS3
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR r1148
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Active transport
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_36a15d30_4629_46f3_8bc6_39343c65d898
type: Species
constant: false
initial concentration: NaN
is: P04075
is encoded by: hsa:226
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ALDOA

metaM acald c
is: SBO:0000247
name: acetaldehyde
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
initial amount: NaN
has only substance units: false
is: HMDB00990

http://identifiers.org/biomodels.db/MODEL1310110033#_56de6298_f5a8_4845_8994_aa8a30969ecd
name: _AI378339_1_m
is encoded by: hsa:AI378339
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110033#_5eb42895_e948_4da5_8bc3_9213d24ba648
initial amount: NaN
type: Species
name: ADSSL1
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is: Q8N142
has only substance units: false
is encoded by: hsa:122622

http://identifiers.org/biomodels.db/MODEL1310110033#_c6c74b14_9c53_43b4_b215_7050fc5e8cae
constant: false
initial amount: NaN
is encoded by: hsa:112724
is: B3KVA3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: RDH13
type: Species

metaM glac c
name: D-glucurono-6,3-lactone
is: HMDB06355
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:18268

http://identifiers.org/biomodels.db/MODEL1310110033#_48c53a60_05a8_4938_8f39_b14ebd8ea7a7
initial amount: NaN
is: Q9UBF8
constant: false
boundary condition: true
type: Species
has only substance units: false
name: PI4KB
is encoded by: hsa:5298
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_fa021309_f860_4cb2_81d9_8c36fb922809
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:51227
boundary condition: true
name: PIGP
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_7efd853d_a18c_405b_9159_89cc5489ac83
initial concentration: NaN
name: HSD17B7
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: P56937
boundary condition: true
is encoded by: hsa:51478
type: Species

metaM ascb L e
is: HMDB00044
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: L-ascorbate
constant: false
is: CHEBI:38290
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074

metaR r1147
type: Reaction
product: MODEL1310110033#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110033#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110033#
fast: false

metaR DCK2n
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110033#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (UTP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_2fa11b47_20f4_454d_bb7d_b9edf5206707
constant: false
is: SBO:0000252
has only substance units: false
name: GALNT10
type: Species
initial concentration: NaN
is: Q86SR1
initial amount: NaN
is encoded by: hsa:55568
boundary condition: true

metaR r2140
reactant: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110033#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_ea5569d8_cb5a_4e16_9c84_016a7f00ac60
initial concentration: NaN
name: PANK3
boundary condition: true
type: Species
is: Q9H999
constant: false
is encoded by: hsa:79646
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM acald e
has only substance units: false
boundary condition: false
type: Species
name: acetaldehyde
initial concentration: 1.0
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
initial amount: NaN
is: HMDB00990
is: SBO:0000247
constant: false

metaR DGTPtn
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
name: dGTP diffusion in nucleus
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110033#

metaM ksi deg4 l
initial amount: NaN
constant: false
is: SBO:0000247
name: keratan sulfate I, degradation product 4
is: CHEBI:57737
has only substance units: false
is: HMDB00868
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C222H355N15O197S12 CHARGE: -12

metaR 2HBt2
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: 2-hydroxybutyrate cotransport with proton
type: Reaction
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000269
fast: false

metaM acgam1p c
name: N-Acetyl-D-glucosamine 1-phosphate
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
constant: false
is: HMDB01367
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:7125
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_810fbb1c_e8f3_4969_bc13_aac6b789bd14
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: B8ZZR8
name: GGCT
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:79017

metaM lys L x
is: SBO:0000247
has only substance units: false
name: L-lysinium(1+)
constant: false
initial amount: NaN
is: HMDB00182
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110033#_605f6b06_2079_4568_a7ac_2abc0b63e7ad
constant: false
name: FOLR1
is: SBO:0000252
is encoded by: hsa:2348
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

metaR S6TASE1ly
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110033#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110033#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110033#
product: MODEL1310110033#

metaR CRNrtx
reactant: MODEL1310110033#
name: reversible transport of L-Carnitine in peroxisome
is described by: ECO:0000134
fast: false
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
kinetic law: MODEL1310110033#

metaM amet c
is: HMDB01185
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: S-Adenosyl-L-methionine
is: CHEBI:15414
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019

metaM ascb L c
is: SBO:0000247
type: Species
is: HMDB00044
initial amount: NaN
boundary condition: false
constant: false
name: L-ascorbate
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
has only substance units: false
is: CHEBI:38290
initial concentration: 1.0

metaM gacpail hs r
has only substance units: false
is: C00092
initial amount: NaN
constant: false
is: HMDB01401
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: CHEBI:61548
name: glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR HSD17B9r
reactant: MODEL1310110033#
type: Reaction
reversible: false
is described by: ECO:0000304
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.1.1.62
name: 17-beta-hydroxysteroid dehydrogenase (type 7)
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (51478.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES:see PMID: 14643063 inferred use of O2 for oxidation - biochemical details have not yet been experimentally elucidated NJ
fast: false
is: SBO:0000176

metaR FACOAL140i
reversible: false
fast: false
kinetic law: MODEL1310110033#
name: fatty-acid--CoA ligase (tetradecanoate)
is: SBO:0000176
modifier: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR

metaM cs e deg6 l
initial amount: NaN
is: HMDB01354
initial concentration: 1.0
notes: FORMULA: C31H48NO32S2 CHARGE: -3
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
type: Species
is: SBO:0000247
constant: false
is: CHEBI:57455
boundary condition: false
has only substance units: false

metaR KAS8
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
name: b-ketoacyl synthetase (palmitate, n-C16:0)
modifier: MODEL1310110033#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_78d6639f_78c6_43fd_9ac3_075c5146ee24
has only substance units: false
name: GALNT2
initial concentration: NaN
boundary condition: true
type: Species
is: Q10471
initial amount: NaN
constant: false
is encoded by: hsa:2590
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_966dff05_99b3_47dc_9872_31b5fd2116db
is encoded by: hsa:50506
is: Q9NRD8
is: SBO:0000252
boundary condition: true
name: DUOX2
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_4928e42a_96a1_4505_b740_45d42837ec6d
initial concentration: NaN
type: Species
constant: false
name: CPT1C
is: SBO:0000252
is encoded by: hsa:126129
is: Q8TCG5
has only substance units: false
initial amount: NaN
boundary condition: true

metaR GBAl
fast: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
type: Reaction
product: MODEL1310110033#
name: Glucosylceramidase
is version of: http://identifiers.org/ec-code/3.2.1.45

http://identifiers.org/biomodels.db/MODEL1310110033#_fd843047_e927_45b3_ad87_2ec27acd012b
name: PIGF:PIGG
has only substance units: false
is encoded by: hsa:54872
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has part: Q8NCI4
initial amount: NaN
is: SBO:0000297

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM udpglcur c
initial amount: NaN
is: SBO:0000247
is: CHEBI:58052
boundary condition: false
is: C00167
initial concentration: 1.0
is: HMDB00935
name: UDP-D-glucuronate
type: Species
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
constant: false
has only substance units: false

metaM h2o m
constant: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
initial amount: NaN
is: C00001
is: SBO:0000247
is: HMDB02111
initial concentration: 1.0
is: CHEBI:15377
boundary condition: false
name: H2O
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_5f6bc076_dc1a_484d_9bb4_fca1ab7dec66
is: SBO:0000252
name: _AV727634_1_c
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AV727634

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaM ser D c
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: D-serine
has only substance units: false
is: CHEBI:16523
is: HMDB03406
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

metaR r2408
reactant: MODEL1310110033#
reversible: false
fast: false
is: SBO:0000185
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_7948c96f_2d9e_4bbb_8b7c_2011801282c4
is: Q96P26
has only substance units: false
initial concentration: NaN
name: NT5C1B
boundary condition: true
is encoded by: hsa:93034
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_541bf35e_eb4f_45ed_a895_bc2b038fdbf4
is: Q6IBC4
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:4726
name: NDUFS6
initial concentration: NaN

metaR r1722
modifier: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110033#
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110033#

metaR S2TASE2ly
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
name: iduronate-2-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_bcc09b14_985b_4850_a8c9_bc852418dd53
boundary condition: true
constant: false
name: HK1
type: Species
is encoded by: hsa:3098
initial amount: NaN
is: A8K7J7
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_d84a260b_4d7b_40ca_8a7f_1e68e488ea7a
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: HCST
boundary condition: true
is encoded by: hsa:10870
is: SBO:0000252
is: Q9UBK5

http://identifiers.org/biomodels.db/MODEL1310110033#_a220eb31_b128_4b4c_a29a_bc0fe98e3c63
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM h2o l
is: HMDB02111
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
boundary condition: false
constant: false
type: Species
initial amount: NaN
name: water
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110033#_2fab782d_4cb7_4354_b506_265b8d82f4a7
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:AI971036
has only substance units: false
type: Species
name: _AI971036_1_x

metaR r0780
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
is described by: ECO:0000000
modifier: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM ser D e
initial amount: NaN
is: CHEBI:16523
initial concentration: 1.0
is: HMDB03406
name: D-serine
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
type: Species

metaM fprica c
is: SBO:0000247
has only substance units: false
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01439
is: CHEBI:58467
constant: false
is: C04734
boundary condition: false

metaM thymd c
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00273
is: CHEBI:17748
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: SBO:0000247
name: Thymidine
initial amount: NaN

metaM 25aics c
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: SBO:0000247
type: Species
is: CHEBI:58443
is: HMDB00797
boundary condition: false
initial concentration: 1.0
constant: false
is: C04823
has only substance units: false
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
initial amount: NaN

metaM hdca r
constant: false
is: HMDB00220
is: CHEBI:7896
type: Species
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Hexadecanoate (n-C16:0)
is: C00249

metaM CE5160 r
constant: false
initial amount: NaN
has only substance units: false
name: 3-oxo-cis-9-octadecenoyl-CoA
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
is: CHEBI:57923
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM 7dhchsterol c
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial concentration: 1.0
type: Species
is: HMDB00032
initial amount: NaN
constant: false
name: cholesta-5,7-dien-3beta-ol
is: CHEBI:17759
is: SBO:0000247
boundary condition: false

metaM HC01118 r
name: presqualene diphosphate(3-)
type: Species
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57310
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_b6f06800_8380_44cb_91ef_a8024f679b33
type: Species
name: _AI990637_1_x
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI990637
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaR r2141
is: SBO:0000185
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110033#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM glx c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: CHEBI:36655
name: glyoxylate
constant: false
is: HMDB00119
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_7250593f_7d2c_44d5_8d70_c2a5e7c8d7ab
is: Q8NFW8
type: Species
is: SBO:0000252
name: CMAS
has only substance units: false
boundary condition: true
is encoded by: hsa:55907
initial amount: NaN
initial concentration: NaN
constant: false

metaM HC00460 c
initial concentration: 1.0
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 2,5-dihydroxybenzoate
is: CHEBI:58044
boundary condition: false

metaM h2o n
is: HMDB02111
constant: false
is: CHEBI:15377
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: water

metaR SPMTDe
product: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110033#
type: Reaction
name: SPMTDe
fast: false
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_ebb0322e_e604_43d9_a9f9_450811c78854
name: SLC2A14
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is: Q8TDB8
type: Species
initial amount: NaN
is encoded by: hsa:144195

metaR ACSm
kinetic law: MODEL1310110033#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 2 AUTHORS: PMID:11150295,PMID:4326157 NOTES:IF
name: acetyl-CoA synthetase
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110033#

metaR r2142
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110033#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_ec39b8c2_6f15_46e1_9669_338243247be6
type: Species
has part: P48736
initial concentration: NaN
is encoded by: hsa:10870
initial amount: NaN
boundary condition: true
has part: Q9UBK5
is: SBO:0000297
has only substance units: false
constant: false
is encoded by: hsa:5294
name: HCST:PIK3CG

http://identifiers.org/biomodels.db/MODEL1310110033#_2caf3a98_24c6_4e5a_967d_6e6e14c0d530
initial concentration: NaN
is encoded by: hsa:222
type: Species
name: ALDH3B2
constant: false
is: SBO:0000252
has only substance units: false
is: P48448
initial amount: NaN
boundary condition: true

metaM ksii core4 deg3 l
is: HMDB00143
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
type: Species
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 3
constant: false
initial concentration: 1.0

metaR RE1796R
name: RE1796
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is: SBO:0000176
reactant: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.145

metaR r0208
is version of: http://identifiers.org/ec-code/4.4.1.1
kinetic law: MODEL1310110033#
is described by: ECO:0000000
product: MODEL1310110033#
modifier: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
fast: false
is: SBO:0000176
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
type: Reaction

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_70d4e678_a78d_4624_9b74_4d1cbe029948
name: ALDH3A2
is: P51648
is encoded by: hsa:224
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_4f0bd205_a56c_4ba3_a828_ff35ad8a42fe
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O95497
is encoded by: hsa:8876
is: SBO:0000252
name: VNN1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_0da9e53c_28e2_4371_8d3f_7da30d5976fd
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: Q08828
constant: false
is: SBO:0000252
is encoded by: hsa:107
name: ADCY1
has only substance units: false

metaM HC01410 m
is: CHEBI:28706
initial amount: NaN
boundary condition: false
type: Species
name: (2E)-Hexenoyl-CoA
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_58f6c31e_e08b_4542_ade1_f8d054851b8e
boundary condition: true
type: Species
is: P56385
initial concentration: NaN
constant: false
is: SBO:0000252
name: ATP5I
initial amount: NaN
has only substance units: false
is encoded by: hsa:521

metaR HISCAT1
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_5d76158e_070a_44b4_8936_f93bd039916d
has only substance units: false
name: PIGQ
is encoded by: hsa:9091
constant: false
initial concentration: NaN
is: B2RAU6
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN

metaM amet m
constant: false
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
has only substance units: false
is: HMDB01185
is: C00019
name: S-Adenosyl-L-methionine
initial amount: NaN
is: SBO:0000247
is: CHEBI:15414
boundary condition: false

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR DTTPtn
reversible: true
type: Reaction
name: dTTP diffusion in nucleus
reactant: MODEL1310110033#
fast: false
is: SBO:0000185
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaM udp e
boundary condition: false
initial concentration: 1.0
type: Species
name: UDP(3-)
is: SBO:0000247
is: CHEBI:58223
has only substance units: false
constant: false
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR D 3AIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110033#
fast: false
name: D-3-amino-isobutyrate transport
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#

metaR S23Tg
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
modifier: MODEL1310110033#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.4

metaM asp L m
is: HMDB00191
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial amount: NaN
constant: false
name: L-aspartate(1-)
has only substance units: false
is: CHEBI:29991

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_74e20282_cae4_4440_bdd8_aad931c9e13e
name: PIP5K1B
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8395
is: O14986
type: Species

metaR r2518
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
reactant: MODEL1310110033#
fast: false
reversible: true
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000185
product: MODEL1310110033#

metaM pail3p hs n
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:58088
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549

metaR DTTPtm
reactant: MODEL1310110033#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
reversible: false
name: transport of dTTP into mitochondria
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000134

metaM gullac c
has only substance units: false
initial amount: NaN
name: L-gulono-1,4-lactone
initial concentration: 1.0
is: CHEBI:17587
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
is: HMDB03466
constant: false

metaR NACHEX25ly
reactant: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_e9368081_7436_4247_ade1_f0cc41feec21
name: PDE7A
constant: false
initial concentration: NaN
is: Q13946
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:5150

http://identifiers.org/biomodels.db/MODEL1310110033#_ba5aca2a_fde4_4587_b66b_52e33e5f9989
initial concentration: NaN
is: B3KQ63
name: HPD
constant: false
is encoded by: hsa:3242
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_d96c69ef_ec84_478f_9b83_f1be64c1342b
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:4716
initial concentration: NaN
boundary condition: true
type: Species
is: A8K761
is: SBO:0000252
name: NDUFB10

metaR PI34P5K
kinetic law: MODEL1310110033#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.68
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6e20737f_b7dc_47e5_847f_93fe47b21983
is: SBO:0000252
type: Species
name: PIGX
constant: false
has only substance units: false
boundary condition: true
is: Q8TBF5
initial concentration: NaN
is encoded by: hsa:54965
initial amount: NaN

metaR THRGLYexR
name: L-threonine/glycine reversible exchange
reactant: MODEL1310110033#
reversible: true
product: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110033#
is described by: ECO:0000304

metaM udp c
has only substance units: false
initial amount: NaN
type: Species
name: UDP
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: CHEBI:58223
is: C00015
is: HMDB00295

metaM acald m
is: SBO:0000247
is: HMDB00990
is: CHEBI:15343
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
has only substance units: false
constant: false
type: Species
name: acetaldehyde
initial concentration: 1.0

metaR ALAALAPEPT1tc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Alanylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR r2519
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:

metaR NDP8
modifier: MODEL1310110033#
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.9
is described by: ECO:0000269
name: nucleoside-diphosphatase (dUDP)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_1ef9632f_1e7b_4f2b_a3e3_7ac0c0b7d677
is: SBO:0000252
type: Species
is: B7Z5T8
constant: false
boundary condition: true
name: CPT1B
initial concentration: NaN
is encoded by: hsa:1375
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_9b88ddf5_4843_4206_8be7_2d78970c827a
is: O00142
type: Species
is encoded by: hsa:7084
initial amount: NaN
is: SBO:0000252
name: TK2
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_ef5dbbf5_d46c_43ef_bb00_9d0859877ca8
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q13613
initial concentration: NaN
name: MTMR1
is encoded by: hsa:8776
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_b97937e3_6511_4223_b095_69c0bcd2fda9
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: NMNAT2
is encoded by: hsa:23057
initial concentration: NaN
type: Species
initial amount: NaN

metaM 5thf e
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB06487
name: pentaglutamyl folate (THF)
notes: FORMULA: C39H45N11O18 CHARGE: -6
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

metaR 3SALAOX
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:as described in Bender (Nutritional biochmeistry of the vitamins, 2nd edition) MM
reactant: MODEL1310110033#
name: cysteinesulfinic acid oxidase

metaM h2o r
is: CHEBI:15377
type: Species
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
is: HMDB02111
is: SBO:0000247
is: C00001
initial concentration: 1.0
initial amount: NaN
constant: false
name: H2O
boundary condition: false

metaM gmp c
initial concentration: 1.0
has only substance units: false
is: C00144
is: CHEBI:58115
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
name: GMP
type: Species
is: HMDB01397
is: SBO:0000247
boundary condition: false

metaM CE2838 e
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
type: Species
name: maltononaose
is: C01936
initial amount: NaN
has only substance units: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
constant: false
boundary condition: false

metaM gq1c hs g
is: CHEBI:28058
has only substance units: false
name: GQ1c
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_8deecbe6_d62a_4161_898d_f173ac24caee
constant: false
name: _NM_001929_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:NM 001929
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaM hdca l
has only substance units: false
is: HMDB00220
is: SBO:0000247
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:7896
name: palmitate

metaR FACOAL80i
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
product: MODEL1310110033#
name: fatty-acid--CoA ligase (octanoate)
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
reversible: false

metaM asp D c
constant: false
initial concentration: 1.0
boundary condition: false
name: D-aspartate(1-)
is: HMDB06483
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: CHEBI:29990

metaR FERO
reactant: MODEL1310110033#
reversible: false
modifier: MODEL1310110033#
is described by: ECO:0000134
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
type: Reaction
name: ferroxidase
fast: false
product: MODEL1310110033#
is: SBO:0000176

metaR GLRASE
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
type: Reaction
name: glucuronolactone reductase
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110033#

metaM hs deg16 l
is: CHEBI:21338
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: heparan sulfate, degradation product 16
initial amount: NaN
is: HMDB02704
type: Species

metaM HC01231 c
type: Species
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
is: CHEBI:58480
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

metaM 2425dhvitd3 m
is: SBO:0000247
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1 EHMN_ABBREVIATION: CE1337
initial concentration: 1.0
constant: false
name: (24R)-24,25-dihydroxycalciol
type: Species
is: CHEBI:28818
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_97f423ed_92cc_483b_b5f3_3ba175f66c97
type: Species
is: SBO:0000252
initial amount: NaN
name: _U37519_1_e
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:U37519
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_52320f86_37a8_4ada_8baa_cccbc75e4c99
name: SLC1A7
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:6512
is: O00341
constant: false
initial concentration: NaN
is: SBO:0000252

metaM gacpail hs c
is: HMDB01401
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C00092
boundary condition: false
constant: false
type: Species
name: glucosaminyl-acylphosphatidylinositol
is: CHEBI:61548
initial amount: NaN
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0

metaM ksi deg19 l
initial amount: NaN
name: keratan sulfate I, degradation product 19
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
constant: false
is: CHEBI:57455
is: HMDB01354

metaR FATP4t
fast: false
reactant: MODEL1310110033#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.2.1.7
notes: GENE_ASSOCIATION: (10998.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
is described by: ECO:0000269
product: MODEL1310110033#
name: fatty acid electroneutral transport

metaM 1pipdn2c x
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
initial concentration: 1.0
has only substance units: false
is: CHEBI:16187
is: SBO:0000247
is: HMDB01084
type: Species
name: 1-piperideine-2-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110033#_b435c282_f958_438c_b686_6b4e3b749f6e
constant: false
initial amount: NaN
name: GART
boundary condition: true
type: Species
is encoded by: hsa:2618
has only substance units: false
is: SBO:0000252
is: P22102
initial concentration: NaN

metaR r2514
reactant: MODEL1310110033#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: Utilized transport
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_fde75901_7bbe_4cf6_83d4_39bc64562405
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: _AU149534_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AU149534

metaR r0202
is: SBO:0000176
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
reversible: true

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaR r1728
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110033#
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110033#
reversible: false
product: MODEL1310110033#

metaR ABTD
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
product: MODEL1310110033#
name: L-arabinitol 4-dehydrogenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_31b52618_4272_43c7_9fcb_d07493c296c4
is encoded by: hsa:81579
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q542Y6
boundary condition: true
is: SBO:0000252
name: PLA2G12A
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_7a016b22_f644_4b90_b252_4a7bcbc7f20f
initial amount: NaN
name: ITPKB
constant: false
is encoded by: hsa:3707
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: P27987

http://identifiers.org/biomodels.db/MODEL1310110033#_793ca7d7_4ad8_4345_9e77_1dce053b8d8b
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: _H77542_1_r
is: SBO:0000252
is encoded by: hsa:H77542
constant: false

metaM udp g
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
boundary condition: false
is: CHEBI:58223
initial concentration: 1.0
constant: false
is: SBO:0000247
name: UDP(3-)
initial amount: NaN
is: HMDB00295
has only substance units: false

metaM asp D e
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06483
type: Species
boundary condition: false
is: SBO:0000247
name: D-aspartate(1-)
is: CHEBI:29990

http://identifiers.org/biomodels.db/MODEL1310110033#_37934d19_2691_41b4_b473_6221d3a8f888
has part: P24310
has part: Q53YB7
has part: P15954
is encoded by: hsa:4513
is encoded by: hsa:9167
is encoded by: hsa:1351
constant: false
is encoded by: hsa:1345
has part: P20674
has part: Q7GXZ8
is encoded by: hsa:84701
has part: Q96KJ9
has part: P00414
type: Species
is encoded by: hsa:1339
is encoded by: hsa:170712
has part: Q6YFQ2
is encoded by: hsa:4514
initial amount: NaN
is encoded by: hsa:1346
boundary condition: true
is encoded by: hsa:125965
initial concentration: NaN
is encoded by: hsa:1349
has only substance units: false
has part: Q8TF08
is encoded by: hsa:1350
has part: Q02221
is encoded by: hsa:341947
is encoded by: hsa:1327
has part: P13073
has part: H0UI06
has part: Q53XN1
is encoded by: hsa:1329
has part: P24311
is encoded by: hsa:1340
has part: P12074
has part: P14854
has part: P09669
is: SBO:0000297
has part: Q7GXY8
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1347
is encoded by: hsa:9377
has part: Q6FGA0
has part: Q7Z4L0
is encoded by: hsa:4512
is encoded by: hsa:1337

metaR ACNAM9PL
is described by: ECO:0000269
product: MODEL1310110033#
reactant: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
type: Reaction
modifier: MODEL1310110033#
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.56
kinetic law: MODEL1310110033#

metaM HC01435 m
name: 3-Carboxy-1-hydroxypropyl-ThPP
has only substance units: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C16H21N4O10P2S CHARGE: -3 INCHI: InChI=1S/C16H24N4O10P2S/c1-9-13(5-6-29-32(27,28)30-31(24,25)26)33-16(12(21)3-4-14(22)23)20(9)8-11-7-18-10(2)19-15(11)17/h7,12,21H,3-6,8H2,1-2H3,(H5-,17,18,19,22,23,24,25,26,27,28)/p+1 EHMN_ABBREVIATION: C05381
is: CHEBI:1463
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110033#_1bad006c_6e91_4192_9728_c241f1fe6e84
type: Species
is encoded by: hsa:4700
constant: false
is: P56556
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: NDUFA6
has only substance units: false

metaM dhcholestanate m
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_62ec5cf8_055f_494a_b082_50a95fdbf9de
is encoded by: hsa:3417
boundary condition: true
is: O75874
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
name: IDH1

metaR r2516
reversible: true
fast: false
reactant: MODEL1310110033#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
kinetic law: MODEL1310110033#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110033#
is: SBO:0000185

metaR TYRt
product: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
name: L-tyrosine transport
fast: false
reactant: MODEL1310110033#
is: SBO:0000185
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is described by: ECO:0000269
reversible: true

metaM spc hs e
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445
type: Species
boundary condition: false
has only substance units: false
name: sphingosylphosphorylcholine

http://identifiers.org/biomodels.db/MODEL1310110033#_dc89c09a_390d_43c3_b0d3_0ef57d5e2074
is encoded by: hsa:3795
name: KHK
initial concentration: NaN
is: Q6IBK2
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6f314a90_c789_4a7b_95ed_3439bb5bf9aa
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:212
name: ALAS2
constant: false
is: Q5JZF5

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_2deb914f_952d_4b56_ac34_8b962da4e6d3
boundary condition: true
constant: false
is: Q9HC58
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: SLC24A3
is encoded by: hsa:57419
initial concentration: NaN

metaR DAGKn hs
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.1.107
type: Reaction
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000269
modifier: MODEL1310110033#
fast: false
name: Diacylglycerol phosphate kinase (homo sapiens)
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110033#_e1bd2c90_6544_4b7e_9592_7c5ee06ce997
constant: false
is encoded by: hsa:6716
initial concentration: NaN
is: P31213
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: SRD5A2
initial amount: NaN

metaR r1595
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110033#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0639
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000000
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110033#
type: Reaction
is: SBO:0000176

metaR PNTK
modifier: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: false
is described by: ECO:0000269
name: pantothenate kinase

metaM HC01496 m
is: CHEBI:28095
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 2-Amino-3-oxoadipate
initial concentration: 1.0
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
constant: false

metaR S6TASE21ly
kinetic law: MODEL1310110033#
product: MODEL1310110033#
modifier: MODEL1310110033#
reactant: MODEL1310110033#
fast: false
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110033#_f8b244d0_8cc9_4c0e_ae47_4b96172c191c
is: B3KQP5
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:8705
boundary condition: true
has only substance units: false
name: B3GALT4
initial concentration: NaN
type: Species

metaR r1883
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_5ccc92c9_4709_44ed_bd88_00d50cbfd2fb
is: B3KT19
constant: false
name: PIK3R1
type: Species
is encoded by: hsa:5295
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR 4HPRO LTte
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
reversible: true
name: Transport of trans-4-hydroxy-L-proline
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110033#

metaR r0779
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
product: MODEL1310110033#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
modifier: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#

metaR r0638
type: Reaction
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.8.1.2

metaR r1596
is: SBO:0000185
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM udp n
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00295
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: CHEBI:58223
name: UDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110033#_3b1e1fe3_9a65_45cc_b644_31a2c642236d
constant: false
name: PIGH
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5283
is: SBO:0000252
type: Species
is: Q14442
boundary condition: true

metaR C6DCCACT
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaM ksi deg35 l
is: CHEBI:12936
name: keratan sulfate I, degradation product 35
has only substance units: false
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
boundary condition: false
is: HMDB00143
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

metaR SBT Dtde
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
name: D-sorbitol transport, extracellular

metaR A4GNT2g
kinetic law: MODEL1310110033#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
product: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000000
reversible: false
fast: false
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction

metaR XOL7AONEtr
name: lipid, flip-flop intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_ff8dd063_502d_4485_ace8_0978bbda692f
initial concentration: NaN
initial amount: NaN
is: Q14642
is encoded by: hsa:3632
is: SBO:0000252
type: Species
constant: false
has only substance units: false
boundary condition: true
name: INPP5A

metaM sebcoa x
name: sebacoylcoa
type: Species
initial concentration: 1.0
initial amount: NaN
is: C14143
constant: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB04047

http://identifiers.org/biomodels.db/MODEL1310110033#_2fa24879_3777_4aa4_99c4_3c5f3d6b501f
is: Q6FIH7
type: Species
name: ATP5G1
initial amount: NaN
is encoded by: hsa:516
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR r1593
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110033#

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR r0926
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
reversible: false
type: Reaction
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
fast: false
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_d090a6ed_163b_410d_9623_a0f8cc767e39
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: Q8NDV1
is encoded by: hsa:256435
name: ST6GALNAC3
initial concentration: NaN

metaM leugly e
name: Leucylglycine
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/97364
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM udp l
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00295
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: SBO:0000247
name: UDP(3-)
is: CHEBI:58223

http://identifiers.org/biomodels.db/MODEL1310110033#_b90b820b_82c0_4591_8318_3f6caada1368
initial amount: NaN
name: NME2
is encoded by: hsa:4831
is: P22392
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_679fe605_e939_4051_818c_237c83e5baea
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: DLST
initial amount: NaN
is encoded by: hsa:1743
is: P36957
initial concentration: NaN
has only substance units: false

metaR r1594
product: MODEL1310110033#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_80672925_0fe2_4c31_ab30_76198558f948
initial concentration: NaN
has only substance units: false
is: Q8NCI4
constant: false
is encoded by: hsa:54872
initial amount: NaN
boundary condition: true
name: PIGG
type: Species
is: SBO:0000252

metaR S6TASE20ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110033#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110033#
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_b39fbb7f_f990_45d5_b1f4_c471a854bc44
type: Species
is: SBO:0000252
name: ST6GALNAC1
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9NSC7
is encoded by: hsa:55808
has only substance units: false

metaM retinal c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
boundary condition: false
has only substance units: false
name: retinal
is: HMDB01358
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:15035

metaR S6TASE18ly
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110033#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110033#
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
fast: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_ad18e97a_5c3b_4611_ab11_cc95247a5071
is: P33261
is encoded by: hsa:1557
name: CYP2C19
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_bfdefa55_e36c_4744_8147_1d6464faa505
constant: false
is: Q9BV79
boundary condition: true
is encoded by: hsa:51102
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: MECR

metaR UPPN
name: b-ureidopropionase
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.5.1.6
modifier: MODEL1310110033#
product: MODEL1310110033#
fast: false
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000176
reversible: false
is described by: ECO:0000269

metaR RE1804M
is described by: ECO:0000000
name: RE1804
is: SBO:0000176
product: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_45c7e78d_5c12_4dde_b18a_9be5ed0c88fa
name: _NM_013421_1_m
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:NM 013421

metaM ksi deg32 l
initial concentration: 1.0
is: HMDB00143
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
has only substance units: false
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 32

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM pe hs r
has only substance units: false
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: CHEBI:16038
is: SBO:0000247
initial concentration: 1.0
name: phosphatidylethanolamine
type: Species
boundary condition: false

metaM dhcholestanate x
is: CHEBI:16577
has only substance units: false
initial amount: NaN
type: Species
is: HMDB00359
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
boundary condition: false
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

http://identifiers.org/biomodels.db/MODEL1310110033#_9bf77f46_8f1f_45da_abe8_62c12b297d22
type: Species
is: SBO:0000252
boundary condition: true
name: SLC25A22
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:79751
is: Q9H936

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR r1591
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110033#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000185
reversible: true

metaM CE5236 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:28002
is: HMDB03952
type: Species

metaM 7dhchsterol r
type: Species
is: HMDB00032
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
constant: false
is: SBO:0000247
is: CHEBI:17759
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: cholesta-5,7-dien-3beta-ol

http://identifiers.org/biomodels.db/MODEL1310110033#_ee4565c2_ddd9_4534_85ec_a87bfcbab267
type: Species
has only substance units: false
is: P14555
initial amount: NaN
constant: false
is encoded by: hsa:5320
initial concentration: NaN
boundary condition: true
name: PLA2G2A
is: SBO:0000252

metaM hdca e
is: HMDB00220
has only substance units: false
constant: false
name: Hexadecanoate (n-C16:0)
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1
is: C00249
is: SBO:0000247
is: CHEBI:0
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM leugly c
initial concentration: 1.0
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/97364
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial amount: NaN
constant: false
is: SBO:0000247
name: Leucylglycine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_f09c7dfb_5f0e_4842_9a2e_1ecd89ebe864
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is: Q13510
name: ASAH1
constant: false
is encoded by: hsa:427

metaM 5hoxindoa c
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:27823
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
is: HMDB00763
name: 5-Hydroxyindoleacetate
type: Species

metaM 3mb2coa m
is: HMDB01493
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
name: 3-methylbut-2-enoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:57344

metaR LEUKTRA4t
reactant: MODEL1310110033#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
name: leukotriene A4 transport
kinetic law: MODEL1310110033#
is: SBO:0000185
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:

metaM crvnc e
constant: false
notes: FORMULA: C22H31O2 CHARGE: -1
type: Species
boundary condition: false
is: HMDB02183
has only substance units: false
name: cervonic acid, C22:6 n-3
is: CHEBI:36005
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_badbf550_e5e9_47d9_be1d_40676a0fc9d7
constant: false
is: P57054
is: SBO:0000252
initial amount: NaN
type: Species
name: PIGP
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51227
has only substance units: false

metaR r0634
fast: false
type: Reaction
modifier: MODEL1310110033#
is: SBO:0000176
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
product: MODEL1310110033#

metaR ILETA
name: isoleucine transaminase
is described by: ECO:0000269
kinetic law: MODEL1310110033#
type: Reaction
reversible: true
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
modifier: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110033#

metaM udp r
initial concentration: 1.0
is: HMDB00295
type: Species
has only substance units: false
name: UDP
is: CHEBI:58223
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
is: C00015
boundary condition: false

metaR RE3218C
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
name: RE3218
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: true
modifier: MODEL1310110033#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
type: Reaction

metaR r1592
product: MODEL1310110033#
reactant: MODEL1310110033#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaM itacon m
is: HMDB02092
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:17240
initial amount: NaN
type: Species
name: itaconate(2-)
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490

metaR 2HBO
reactant: MODEL1310110033#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
kinetic law: MODEL1310110033#
is: SBO:0000176
reversible: true
modifier: MODEL1310110033#
product: MODEL1310110033#
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110033#_90dee6d9_8e29_4261_a6ba_3b6948a946d8
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:60482
name: SLC5A7
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q9GZV3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_d0fa8f3b_6971_4858_a109_e4436d26486f
is encoded by: hsa:6580
has only substance units: false
is: O15245
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: SLC22A1
type: Species

metaR DIDPtn
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: dIDP nuclear transport
type: Reaction
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM spc hs c
type: Species
is: http://identifiers.org/pubchem.compound/5311445
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
name: sphingosylphosphorylcholine
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1

metaR URAt
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction
kinetic law: MODEL1310110033#
product: MODEL1310110033#
is described by: ECO:0000269
name: uracil transport via facilated diffusion
reactant: MODEL1310110033#
is: SBO:0000185
fast: false
reversible: true

metaR r0360
is: SBO:0000176
kinetic law: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
reactant: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.2.1.16
fast: false
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110033#_bf31630b_fb65_455f_80ec_80b00883a2fe
boundary condition: true
type: Species
is encoded by: hsa:1892
has only substance units: false
is: P30084
name: ECHS1
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR TMDS
name: thymidylate synthase
is described by: ECO:0000269
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.45
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is: SBO:0000176

metaR ACNAMlt
name: N-acetylneuraminate transport into lysososme
fast: false
reversible: true
product: MODEL1310110033#
is described by: ECO:0000269
modifier: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185

metaM hdca c
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00220
is: SBO:0000247
has only substance units: false
is: CHEBI:7896
initial concentration: 1.0
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
name: palmitate

metaR DRPA
name: deoxyribose-phosphate aldolase
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110033#
is: SBO:0000176
reactant: MODEL1310110033#
type: Reaction
product: MODEL1310110033#

metaM thcrm hs g
is: CHEBI:24636
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
has only substance units: false
constant: false
is: SBO:0000247
name: trihexosyl ceramide

http://identifiers.org/biomodels.db/MODEL1310110033#_0eb39cd1_ad20_4a9a_b7bf_224d39dce0c5
type: Species
has only substance units: false
is: P51648
name: ALDH3A2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:224

http://identifiers.org/biomodels.db/MODEL1310110033#_39037727_a86e_46d6_ad61_4bd314d3f726
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: P78330
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5723
name: PSPH

metaM glac r
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
name: D-glucurono-6,3-lactone
constant: false
is: HMDB06355
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:18268
initial concentration: 1.0

metaM dag hs r
initial concentration: 1.0
constant: false
is: CHEBI:18035
has only substance units: false
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: diglyceride

metaR GLYSARCNc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_526e70b1_ce45_4ec1_8acd_6f5107e94de3
initial concentration: NaN
has only substance units: false
type: Species
is: Q9H1K4
boundary condition: true
initial amount: NaN
is encoded by: hsa:83733
constant: false
is: SBO:0000252
name: SLC25A18

metaR r1590
product: MODEL1310110033#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false

metaM asn L c
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
is: CHEBI:17196
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00168

http://identifiers.org/biomodels.db/MODEL1310110033#_2acc1527_e707_40a2_9cd4_ef2a3646d40c
initial concentration: NaN
initial amount: NaN
type: Species
is: P14060
is encoded by: hsa:3283
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: HSD3B1

http://identifiers.org/biomodels.db/MODEL1310110033#_eb06309f_b7da_4b9c_9b5c_1a20b6d2f511
constant: false
is: E7EPT3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:501
initial amount: NaN
boundary condition: true
name: ALDH7A1
type: Species
has only substance units: false

metaR B3GALT43g
fast: false
reversible: false
product: MODEL1310110033#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.62
name: Beta-1,3-galactosyltransferase 4
modifier: MODEL1310110033#
notes: GENE_ASSOCIATION: (8705.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.62 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_9b6cb3bc_b5f9_42f4_83a2_8f18d1281953
name: SOAT2
is encoded by: hsa:8435
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O75908
boundary condition: true
initial concentration: NaN
constant: false

metaM 4aphdob c
type: Species
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: CHEBI:58147
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00978

http://identifiers.org/biomodels.db/MODEL1310110033#_a0281084_991b_495f_a102_d821cc65f7a4
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: PIK3C2A
is encoded by: hsa:5286
is: O00443
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_09ff1f9c_ac46_4b6a_82c1_e3e0c42a5a56
is: O00217
name: NDUFS8
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4728
boundary condition: true
initial concentration: NaN
type: Species

metaR r0630
modifier: MODEL1310110033#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: true
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110033#
is described by: ECO:0000000
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false

metaM tag hs c
has only substance units: false
is: CHEBI:17855
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
boundary condition: false
type: Species
name: triglyceride
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR PIK3
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
product: MODEL1310110033#
type: Reaction
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.137
is: SBO:0000176
modifier: MODEL1310110033#
name: phosphatidylinositol 3-kinase
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110033#_dff2d4a4_f9b2_4347_88d6_c489d22ea74b
type: Species
boundary condition: true
is: Q6P1K9
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:80025
name: PANK2
is: SBO:0000252

metaR r0365
reactant: MODEL1310110033#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
reversible: false
product: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110033#_5ed15de1_0c27_4e77_9832_9b6461680e5d
type: Species
boundary condition: true
is: B3KMA6
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2181
has only substance units: false
name: ACSL3

metaR GLCNACASE3ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_aa1f96a8_22e4_4ebc_aecf_b20efb0778f4
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
name: ADH5
is encoded by: hsa:128
is: Q6IRT1
is: SBO:0000252
has only substance units: false
constant: false

metaR r0774
type: Reaction
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110033#
fast: false
product: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
reactant: MODEL1310110033#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_19668cb7_f020_4bb0_933c_1cb77a671d40
is: G3V4L5
is encoded by: hsa:89874
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC25A21

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR AICARte
product: MODEL1310110033#
is: SBO:0000185
kinetic law: MODEL1310110033#
is described by: ECO:0000134
reversible: true
fast: false
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_1f706b47_cd27_4be0_9275_173171ff1e59
is encoded by: hsa:AA502753
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: _AA502753_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_9dcd4b8a_e513_4f3c_b232_cca3bf853682
is: SBO:0000252
is encoded by: hsa:2821
initial concentration: NaN
type: Species
is: P06744
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: GPI

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaM gq1balpha hs g
name: GQ1balpha
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: C00249
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
is: HMDB00220
is: CHEBI:7896
constant: false

http://identifiers.org/biomodels.db/MODEL1310110033#_b6db7224_74df_4c1a_826c_5dd4967baac6
is: Q1LZ56
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:206358
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLC36A1
boundary condition: true

metaR ATP2ter
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: true
product: MODEL1310110033#
name: AMP/ATP transporter, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110033#_6a032409_ce5c_46f8_b024_48eb9bd172e2
has part: Q9HCC0
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:56922
is: SBO:0000297
has only substance units: false
name: MCCC1:MCCC2
initial amount: NaN
boundary condition: true
is encoded by: hsa:64087
has part: Q96RQ3

http://identifiers.org/biomodels.db/MODEL1310110033#_9bf1a5d4_3037_4502_8200_2a1d4b4b6795
is encoded by: hsa:54511
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9NT06
type: Species
name: HMGCLL1
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_cafbdcb4_6838_4e92_99d4_f449b5b3210b
initial amount: NaN
constant: false
is encoded by: hsa:4830
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P15531
name: NME1
initial concentration: NaN
type: Species

metaM hs deg22 l
boundary condition: false
is: HMDB02704
is: SBO:0000247
notes: FORMULA: C37H56NO35S CHARGE: -3
initial concentration: 1.0
initial amount: NaN
constant: false
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species
has only substance units: false
is: CHEBI:21338

metaM 3php c
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 3-phosphonatooxypyruvate(3-)
initial amount: NaN
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
has only substance units: false
is: CHEBI:18110
is: HMDB01024
boundary condition: false

metaM xmp c
initial concentration: 1.0
constant: false
is: CHEBI:57464
type: Species
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
is: HMDB01554
initial amount: NaN
boundary condition: false
name: Xanthosine 5'-phosphate
has only substance units: false
is: SBO:0000247
is: C00655

metaM dgsn m
is: C00330
initial concentration: 1.0
is: SBO:0000247
is: HMDB00085
is: CHEBI:17172
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
name: Deoxyguanosine
has only substance units: false

metaM crvnc c
boundary condition: false
name: cervonic acid, C22:6 n-3
constant: false
notes: FORMULA: C22H31O2 CHARGE: -1
initial amount: NaN
is: HMDB02183
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:36005
has only substance units: false

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaM h2o c
notes: FORMULA: H2O CHARGE: 0
has only substance units: false
constant: false
is: C00001
is: SBO:0000247
initial amount: NaN
is: HMDB02111
boundary condition: false
type: Species
name: H2O
is: CHEBI:3303
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110033#_9868a528_a9d9_4d92_b1c1_cdc5d4f2a34d
is encoded by: hsa:3990
has only substance units: false
initial concentration: NaN
is: A6H8L5
initial amount: NaN
name: LIPC
constant: false
is: SBO:0000252
boundary condition: true
type: Species

metaR S6TASE26ly
is: SBO:0000176
reactant: MODEL1310110033#
fast: false
modifier: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110033#_9d03e58c_4db5_4e62_a51f_58b5f343ef29
is encoded by: hsa:34
has only substance units: false
name: ACADM
is: P11310
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r1599
type: Reaction
fast: false
reactant: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM gq1balpha hs e
constant: false
is: HMDB01397
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58115
name: GQ1balpha
has only substance units: false
initial amount: NaN
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4
type: Species
boundary condition: false

metaR MDHm
is version of: http://identifiers.org/ec-code/1.1.1.37
product: MODEL1310110033#
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110033#
fast: false
name: malate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reversible: true
modifier: MODEL1310110033#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110033#_b75536e5_8a45_48e7_b5ee_aef8416d8936
is: Q11201
name: ST3GAL1
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6482

metaR GLCAASE9ly
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reversible: false
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110033#
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
fast: false

metaR r1487
is: SBO:0000176
product: MODEL1310110033#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110033#
is described by: ECO:0000000
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110033#

metaM ppi x
is: SBO:0000247
boundary condition: false
is: HMDB00250
initial concentration: 1.0
has only substance units: false
is: C00013
constant: false
type: Species
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: CHEBI:33019

W3 CDTF: Thu Aug 30 10:41:36 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110033#_5c8d60e7_7894_4ca2_8c2c_18658e4aea03
boundary condition: true
is: P16219
constant: false
is: SBO:0000252
type: Species
name: ACADS
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:35

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR S4TASE4ly
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.12
modifier: MODEL1310110033#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110033#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110033#

metaR IDOAASE3ly
kinetic law: MODEL1310110033#
product: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
reversible: false
name: alpha-L-iduronidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110033#
modifier: MODEL1310110033#

metaM h2o e
name: H2O
constant: false
has only substance units: false
boundary condition: false
is: C00001
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
type: Species
initial amount: NaN
is: HMDB02111
initial concentration: 1.0

metaR HACD9m
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
reactant: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction
fast: false
product: MODEL1310110033#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000134
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reversible: true
kinetic law: MODEL1310110033#

metaM asn L e
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
name: L-asparagine
is: HMDB00168
initial amount: NaN
is: CHEBI:17196
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false

W3 CDTF: Thu Aug 30 10:41:36 BST 2012

metaR r1597
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110033#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_992cadec_2832_46fc_8682_8fb78f10a187
type: Species
is encoded by: hsa:2678
has only substance units: false
is: P19440
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: GGT1
constant: false

metaR CLHCO3tex2
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
is: SBO:0000185
modifier: MODEL1310110033#
fast: false
product: MODEL1310110033#
reversible: false
reactant: MODEL1310110033#
name: chloride transport via bicarbonate countertransport (2:1)
kinetic law: MODEL1310110033#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110033#_e126bff8_edf2_4fd2_b391_d708923503ee
name: PIGX:PIGM
has part: Q9H3S5
is: SBO:0000297
is encoded by: hsa:54965
initial concentration: NaN
constant: false
is encoded by: hsa:93183
type: Species
has only substance units: false
has part: Q8TBF5
boundary condition: true
initial amount: NaN

metaM HC01609 e
has only substance units: false
is: CHEBI:28766
initial concentration: 1.0
name: UroporphyrinogenI
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
is: SBO:0000247

metaM gq1balpha hs c
is: CHEBI:7896
initial concentration: 1.0
name: GQ1balpha
type: Species
is: C00249
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00220
constant: false
is: SBO:0000247
notes: FORMULA: C88H143N6O54FULLRCO CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110033#_15d65ea2_2b7f_4e3d_a06c_5514a4e9dc6d
initial amount: NaN
is: SBO:0000252
name: OXSM
type: Species
boundary condition: true
constant: false
is encoded by: hsa:54995
has only substance units: false
is: Q9NWU1
initial concentration: NaN

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM ru5p D c
is: HMDB00618
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:58121
is: SBO:0000247
name: D-ribulose 5-phosphate(2-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110033#_529e3ab3_5029_4a8f_8085_a48e99387069
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: GCNT1
type: Species
is: SBO:0000252
is encoded by: hsa:2650
is: Q02742

metaR O2Stm
kinetic law: MODEL1310110033#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110033#
fast: false
type: Reaction
name: superoxide anion transport via diffusion (mitochondria)
is described by: ECO:0000000
product: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_d1a5dadc_8100_40d4_b5c2_53472bbef749
constant: false
initial amount: NaN
is: SBO:0000252
is: B3KRT1
name: ISYNA1
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:51477
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110033#_ca9a4c11_8a5b_4c4c_9a89_ecf2159d9fc1
constant: false
boundary condition: true
name: CROT
type: Species
initial amount: NaN
is encoded by: hsa:54677
has only substance units: false
is: SBO:0000252
is: E7EQF2
initial concentration: NaN

metaM CE5121 m
name: trans-3-decenoyl-CoA
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
type: Species
constant: false
is: CHEBI:57449
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_6044b36d_bbb2_4b90_9360_fe00ae3a1ec1
initial amount: NaN
is: P51648
type: Species
name: ALDH3A2
constant: false
is encoded by: hsa:224
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR CYSTLEUrBATtc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Cystine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaM core2 g
type: Species
name: Core 2
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: CHEBI:15876
has only substance units: false
initial amount: NaN
constant: false

metaR r1598
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110033#
is: SBO:0000185
type: Reaction
product: MODEL1310110033#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#

metaR ACHEe
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
reversible: false
fast: false
reactant: MODEL1310110033#
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.1.7
name: Acetylcholinesterase
modifier: MODEL1310110033#
type: Reaction
kinetic law: MODEL1310110033#
is: SBO:0000176

metaM h2o g
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial amount: NaN
is: HMDB02111
type: Species
name: water
initial concentration: 1.0
constant: false

metaR HMGCOASim
modifier: MODEL1310110033#
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is version of: http://identifiers.org/ec-code/2.3.3.10
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110033#
name: Hydroxymethylglutaryl CoA synthase (ir)
kinetic law: MODEL1310110033#
type: Reaction
fast: false
is: SBO:0000176

metaM tag hs e
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
name: triglyceride
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:17855

metaR PPD2CSPp
name: PPD2CSPp
fast: false
is described by: ECO:0000000
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110033#

metaR LTD4DP
product: MODEL1310110033#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
type: Reaction
name: Leukotriene D4 dipeptidase
is described by: ECO:0000000

metaR PROSTGH2t
name: Prostaglandin H2 transport
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
type: Reaction
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000269

metaR PAIL HStn
is described by: ECO:0000000
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
product: MODEL1310110033#
fast: false
reversible: true
reactant: MODEL1310110033#
name: phosphatidylinositol nuclear transport (diffusion)
is: SBO:0000185

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM estradiol e
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
name: estradiol
boundary condition: false
is: HMDB00151
is: CHEBI:16469
constant: false

metaR DGNSKm
reactant: MODEL1310110033#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: false
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
is described by: ECO:0000269
name: deoxyguanosine kinase
is version of: http://identifiers.org/ec-code/2.7.1.113

metaR r2387
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110033#
modifier: MODEL1310110033#
fast: false
is described by: ECO:0000000

metaR DOPAt4 2 r
name: Dopamine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
is: SBO:0000185
fast: false
kinetic law: MODEL1310110033#
reversible: true
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110033#
modifier: MODEL1310110033#
type: Reaction

metaR FE2t
name: iron (II) transport
reactant: MODEL1310110033#
reversible: false
is: SBO:0000185
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12440707 NOTES:
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaM ctp e
name: CTP(4-)
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
boundary condition: false
is: CHEBI:37563
initial amount: NaN

metaR RE3520E
is version of: http://identifiers.org/ec-code/1.11.1.9
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110033#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
kinetic law: MODEL1310110033#
is described by: ECO:0000000
reactant: MODEL1310110033#
type: Reaction
modifier: MODEL1310110033#
name: RE3520

http://identifiers.org/biomodels.db/MODEL1310110033#_9c989261_5e83_45bb_9317_78ed3458c6e8
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: GPX5
type: Species
is: O75715
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2880

metaM focytC m
name: Ferrocytochrome C
type: Species
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial concentration: 1.0
has only substance units: false
is: CHEBI:16928
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false

metaR HISTAtu
fast: false
product: MODEL1310110033#
type: Reaction
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
name: Histamine uniport
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269

metaM 13dpg c
is: http://identifiers.org/pubchem.compound/3535
name: 3-Phospho-D-glyceroyl phosphate
is: C00236
type: Species
has only substance units: false
is: HMDB01270
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: SBO:0000247
is: CHEBI:57604
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaR DCK1n
kinetic law: MODEL1310110033#
is: SBO:0000176
product: MODEL1310110033#
reversible: true
modifier: MODEL1310110033#
fast: false
name: Deoxycytidine kinase, nuclear (ATP)
is described by: ECO:0000269
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_971cc1f6_26b4_443e_b6b9_10335f7c01e0
name: SLCO2A1
initial amount: NaN
is: Q92959
is encoded by: hsa:6578
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR PSP L
kinetic law: MODEL1310110033#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
is version of: http://identifiers.org/ec-code/3.1.3.3
fast: false
product: MODEL1310110033#
reactant: MODEL1310110033#
modifier: MODEL1310110033#
is described by: ECO:0000269
name: phosphoserine phosphatase (L-serine)
reversible: false

metaR r2388
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110033#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110033#
fast: false
reactant: MODEL1310110033#
kinetic law: MODEL1310110033#
is: SBO:0000185
is described by: ECO:0000000

metaR GALASE12ly
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
reactant: MODEL1310110033#
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110033#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal

metaM cysam c
has only substance units: false
type: Species
name: cysteaminium
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58029
is: SBO:0000247
is: HMDB02991
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678

metaM CE5236 c
is: CHEBI:28002
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM estradiol c
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
initial amount: NaN
initial concentration: 1.0
name: estradiol
boundary condition: false
is: HMDB00151
is: CHEBI:16469

http://identifiers.org/biomodels.db/MODEL1310110033#_49e96d93_501b_4eb2_a057_d08b2447f513
type: Species
name: TPI1P2
initial concentration: NaN
is encoded by: hsa:286016
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN

metaM arg L m
boundary condition: false
is: CHEBI:32682
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
is: HMDB00517
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_06d9a858_bf2f_4b5f_a1b1_b0cd19925691
is encoded by: hsa:10050
constant: false
initial concentration: NaN
name: SLC17A4
is: Q9Y2C5
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110033#_01b2bf15_4e56_45a5_88c5_4d6fe8062c81
name: AKR1D1
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: P51857
type: Species
is: SBO:0000252
is encoded by: hsa:6718
has only substance units: false

metaR r2389
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110033#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110033#
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110033#
modifier: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_b138e44a_626e_4f82_9bd5_292a888b1cf9
is encoded by: hsa:27124
constant: false
boundary condition: true
name: INPP5J
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: Q15735
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110033#_203db361_99f3_425d_9b83_603cc27c23a0
type: Species
is: SBO:0000297
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
has part: Q06055
has only substance units: false
is encoded by: hsa:517

metaR AMETtd
reversible: true
fast: false
is: SBO:0000185
type: Reaction
name: diffusion of S-Adenosyl-L-methionine
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110033#
kinetic law: MODEL1310110033#
is described by: ECO:0000134
reactant: MODEL1310110033#

http://identifiers.org/biomodels.db/MODEL1310110033#_18f09900_6c45_4f12_9585_10b6f631ca52
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6818
is: Q1ET61
initial concentration: NaN
has only substance units: false
name: SULT1A3

http://identifiers.org/biomodels.db/MODEL1310110033#_8e8aa8cb_a7f4_4df7_ae4d_5d66c4ec77d7
is encoded by: hsa:1806
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: DPYD
is: Q12882
constant: false

metaM ctp c
initial amount: NaN
is: C00063
type: Species
has only substance units: false
is: SBO:0000247
name: CTP
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
is: HMDB00082
is: CHEBI:37563

metaR NDP8ex
kinetic law: MODEL1310110033#
modifier: MODEL1310110033#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is: SBO:0000176
name: nucleoside-diphosphatase (UTP), extracellular
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110033#
fast: false
product: MODEL1310110033#

metaR ORNLEUrBATtc
kinetic law: MODEL1310110033#
product: MODEL1310110033#
reactant: MODEL1310110033#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaM hom L c
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
is: CHEBI:15699
has only substance units: false
name: L-homoserine
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00719
boundary condition: false

metaR FATP9t
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
name: fatty acid electroneutral transport
modifier: MODEL1310110033#
is: SBO:0000185
reactant: MODEL1310110033#
fast: false
kinetic law: MODEL1310110033#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
product: MODEL1310110033#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.7

metaM methf c
is: CHEBI:57455
name: 5,10-Methenyltetrahydrofolate
initial concentration: 1.0
is: C00445
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01354
is: SBO:0000247
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
boundary condition: false

metaR H2ETer
fast: false
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110033#
product: MODEL1310110033#
reversible: false
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
name: H2 phosphoethanolaminyl transferase, endoplasmic reticulum
is: SBO:0000176
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110033#_a28cff57_7649_4fbb_bb74_5a8ea1178ea7
boundary condition: true
is encoded by: hsa:686
constant: false
type: Species
is: SBO:0000252
is: P43251
initial concentration: NaN
has only substance units: false
name: BTD
initial amount: NaN

metaM glyc3p c
name: Glycerol 3-phosphate
initial amount: NaN
is: CHEBI:57597
is: C00093
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
is: SBO:0000247
is: HMDB00126
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110033#_11409a6b_4921_433d_8f8b_1102817df9a3
is encoded by: hsa:50
initial amount: NaN
has only substance units: false
constant: false
is: Q99798
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: ACO2

metaM 4ppan c
is: CHEBI:10986
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: HMDB01016
initial concentration: 1.0
name: D-4'-Phosphopantothenate
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false
is: C03492
initial amount: NaN

metaR ADSL1
reactant: MODEL1310110033#
is described by: ECO:0000269
kinetic law: MODEL1310110033#
name: adenylosuccinate lyase
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.2.2
product: MODEL1310110033#
reversible: false
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
modifier: MODEL1310110033#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110033#_45ddc2c0_bb3f_4a59_b7e6_b2cece3a089a
has only substance units: false
is: B7Z4Y6
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:249
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ALPL

http://identifiers.org/biomodels.db/MODEL1310110033#_82f69d48_cc2b_44f6_9c64_110b62d747f0
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: CHAT
type: Species
constant: false
boundary condition: true
is encoded by: hsa:1103
is: D3DX95
initial concentration: NaN

metaR r1154
fast: false
kinetic law: MODEL1310110033#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
reactant: MODEL1310110033#
name: EC:1.2.7.2
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110033#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110033#_b39fd594_676e_4a76_8f9f_e9daeda13335
type: Species
boundary condition: true
name: GBA
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2629
initial concentration: NaN
has only substance units: false
constant: false

metaM dag hs c
has only substance units: false
initial amount: NaN
name: diglyceride
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:18035
type: Species
boundary condition: false
is: SBO:0000247

metaM hdcea e
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:32372
is: SBO:0000247
name: Hexadecenoate (n-C16:1)
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
is: HMDB03229
initial amount: NaN
initial concentration: 1.0

metaR VITD3t2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
is: SBO:0000185
name: Vitamin D3 uptake
reactant: MODEL1310110033#
product: MODEL1310110033#
reversible: false
type: Reaction
kinetic law: MODEL1310110033#
is described by: ECO:0000000

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110033#
reactant: MODEL1310110033#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction