metaM 2dpmhobq m
initial amount: NaN
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: HMDB06484
is: SBO:0000247
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:50771
boundary condition: false

metaM eitetcoa x
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
boundary condition: false
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
name: 5,8,11,14-eicosatetraenoylcoa
constant: false

metaM ocdca e
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
has only substance units: false
initial concentration: 1.0
is: HMDB00827
type: Species
boundary condition: false
is: C01530
initial amount: NaN
name: octadecanoate (n-C18:0)
constant: false
is: SBO:0000247
is: CHEBI:25629

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM CE2417 m
boundary condition: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: CHEBI:28387
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110028#_3f75f39c_c46f_4001_ad7c_4948f59aeb3a
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: LTC4S
is encoded by: hsa:4056
has only substance units: false

metaR FAOXC260240x
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110028#
name: Beta oxidation of long chain fatty acid
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_442277d6_3912_45af_bebf_67ef1526e306
is: Q8N1Q1
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: CA13
is encoded by: hsa:377677
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_c00f2681_6f72_4a2a_beea_dfd0100ef2b1
name: _AA854479_1_m
is: SBO:0000252
is encoded by: hsa:AA854479
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_27ee7a21_2714_473e_a032_e3c99b56ea05
type: Species
is encoded by: hsa:197258
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: FUK
is: Q8N0W3
initial amount: NaN
constant: false
has only substance units: false

metaM HC01401 x
initial concentration: 1.0
constant: false
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false

metaM tetdece1coa c
boundary condition: false
is: SBO:0000247
name: tetradecenoylcoa
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
is: HMDB05066

metaR FAOXC184C163m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_8c49edd0_30e4_475a_8b82_3e0423e4b6a5
name: _728226_1_e
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:728226
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_b95eb044_f1f6_4b7b_96e5_5f54f0acd0ab
name: ABAT
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:18

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_6097f67b_ba11_4b3d_9cbd_8071dd2686cf
boundary condition: true
initial amount: NaN
is: Q01415
type: Species
name: GALK2
is encoded by: hsa:2585
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_867737a9_d9b6_419f_a39a_3ef6fe59abd3
is encoded by: hsa:594
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: BCKDHB
has only substance units: false
is: Q9BQL0

http://identifiers.org/biomodels.db/MODEL1310110028#_9f945e8d_7088_4565_8215_c60c7005d744
has only substance units: false
type: Species
boundary condition: true
is: Q9Y6K8
initial concentration: NaN
name: AK5
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:26289
constant: false

metaR DOLDPP Uer
is version of: http://identifiers.org/ec-code/3.6.1.43
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110028#

metaR r0840
kinetic law: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.70
modifier: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110028#
name: Free diffusion
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_68cbf946_8d37_480d_8e4e_be1708c7bbb4
boundary condition: true
has only substance units: false
is encoded by: hsa:10050
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC17A4
is: Q9Y2C5
initial concentration: NaN

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaR C4STMO2Pr
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: C-4 methyl sterol oxidase
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ

metaM cmpacna n
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
is: HMDB01176
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57812
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaR FAOXC241C221x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_9720e0c1_206e_4567_b418_c5c108df2bbe
has only substance units: false
type: Species
is: SBO:0000252
is: E7EQF2
boundary condition: true
initial amount: NaN
name: CROT
is encoded by: hsa:54677
constant: false
initial concentration: NaN

metaM crm hs e
type: Species
is: CHEBI:52639
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
name: N-acylsphingosine
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_503ab0d9_cfac_47de_b610_86d2a745de60
name: PRODH
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5625
is: O43272
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_acea6d03_49cc_422e_8203_84de71d63699
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: _AI761708_1_m
has only substance units: false
constant: false
is encoded by: hsa:AI761708
initial concentration: NaN

metaM 2hexdtetcoa m
type: Species
initial amount: NaN
has only substance units: false
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 2,7,10,13-hexadecatetraenoylcoa
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_f7c8647c_0788_4191_8dd2_0b377d5c7604
initial concentration: NaN
name: MYO5B
has only substance units: false
initial amount: NaN
is encoded by: hsa:4645
type: Species
is: Q9H6Y6
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_97df932c_b600_4243_858c_9f6078cc3859
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:54995
name: OXSM
is: Q9NWU1

metaR FAOXC204C184m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_26e73e89_0e38_4462_bc61_6b5f5a34a534
type: Species
name: _AD000092_1_c
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AD000092

http://identifiers.org/biomodels.db/MODEL1310110028#_e66bcae5_f8d6_46f4_8dd0_34b7e5d10655
type: Species
is encoded by: hsa:1718
name: DHCR24
initial concentration: NaN
is: Q15392
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaM dolmanp L c
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Dolichyl phosphate D-mannose, human liver homolog
is: CHEBI:15809
initial amount: NaN
constant: false
type: Species

metaR DCYTD
reactant: MODEL1310110028#
name: deoxycytidine deaminase
product: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000254
reversible: false
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.5

http://identifiers.org/biomodels.db/MODEL1310110028#_38ff2b4c_778f_462d_85f9_652ed20b7795
name: NADSYN1
is encoded by: hsa:55191
initial concentration: NaN
initial amount: NaN
constant: false
is: Q6IA69
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_4d07acc8_628e_49b8_b3db_1cbc794e3d1f
is: Q9NR34
initial concentration: NaN
name: MAN1C1
is: SBO:0000252
is encoded by: hsa:57134
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a58f83da_9ddd_4742_9ee8_dd2860b3a394
name: ACADS
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: P16219
initial concentration: NaN
type: Species
is encoded by: hsa:35

metaR r0842
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
name: Postulated transport reaction
is version of: http://identifiers.org/ec-code/1.3.1.72

metaR FUCASEe
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
name: alpha-fucosidase, extracellular
reversible: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.51

metaM 35cgmp c
name: 3',5'-cyclic GMP(1-)
initial amount: NaN
is: HMDB01314
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57746
type: Species
is: SBO:0000247

metaR GAL3ST11
name: Galactosylceramide sulfotransferase
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.11
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM tetdec2crn e
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C21H37NO4 CHARGE: 0
initial amount: NaN
name: tetradecadienoyl carnitine
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB05066

http://identifiers.org/biomodels.db/MODEL1310110028#_acd8f370_f893_483b_95f2_87a34bf781fb
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: GCNT3
is encoded by: hsa:9245
type: Species
is: O95395

metaR FORtr
is described by: ECO:0000000
name: FOR transporter, endoplasmic reticulum
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_bb003b84_947f_4777_82aa_fb7ffc2a01f2
type: Species
is encoded by: hsa:27068
is: SBO:0000252
initial amount: NaN
name: PPA2
is: F8WDN9
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaM tridcoa m
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
has only substance units: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB13109
boundary condition: false
name: tridecanoylcoa

metaR RE2625C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
kinetic law: MODEL1310110028#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
name: RE2625

metaR SERGLNexR
name: L-Serine/Glutamine reversible exchange
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
is described by: ECO:0000304
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
reversible: true

metaR r0841
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.271
is: SBO:0000185
product: MODEL1310110028#
name: Free diffusion
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
kinetic law: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false

metaR FACOAL224
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
name: fatty-acid--CoA ligase
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110028#_8ec1ee10_6723_42ab_a37f_4c654f2baa92
has only substance units: false
boundary condition: true
name: DHCR7
constant: false
is encoded by: hsa:1717
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9UBM7

metaM HC01434 x
type: Species
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:58931

metaR r1088
name: Active transport
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110028#
fast: false

metaM hestratriol e
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB05896
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
name: 4,17 dihydroxy estradiol

metaM tetdec2crn c
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: tetradecadienoyl carnitine
initial amount: NaN
type: Species
notes: FORMULA: C21H37NO4 CHARGE: 0
initial concentration: 1.0
is: HMDB02014

metaM 3mox4hpac m
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: HMDB05175
constant: false
type: Species
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
boundary condition: false
initial concentration: 1.0
is: CHEBI:28111
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR CYSGLUexR
fast: false
product: MODEL1310110028#
is described by: ECO:0000304
reversible: true
is: SBO:0000185
name: L-cysteine/L-glutamine reversible exchanger
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_918287f8_b1ad_4cbc_9187_3d6d2ff10c10
boundary condition: true
has only substance units: false
constant: false
type: Species
is: SBO:0000252
name: FH
initial concentration: NaN
initial amount: NaN
is: P07954
is encoded by: hsa:2271

metaM pep c
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
name: Phosphoenolpyruvate
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:18021
is: HMDB00263
initial concentration: 1.0
is: C00074
initial amount: NaN

metaR UMPK4n
reversible: true
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110028#
reactant: MODEL1310110028#
name: UMP kinase (GTP),nuclear
modifier: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#

metaM 4aphdob c
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
constant: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: CHEBI:58147
type: Species
boundary condition: false
is: HMDB00978
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR S6T16g
product: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_9659de05_e384_4a1d_88a9_60568400a9d7
name: MDH1
constant: false
type: Species
is: B7Z3I7
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4190
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a9e3b08b_bf5c_4202_9f4e_54d6416f702c
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:9488
has only substance units: false
boundary condition: true
is: Q92521
name: PIGB
type: Species
initial amount: NaN

metaM ksi pre35 g
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
type: Species
constant: false
name: keratan sulfate I biosynthesis, precursor 35
initial amount: NaN
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
boundary condition: false
is: SBO:0000247

metaR PAFH
is version of: http://identifiers.org/ec-code/3.1.1.47
reactant: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ
name: Platelet-activating factor acetylhydrolase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_b91a6010_aff0_40b3_bb8d_8731db836f7e
is encoded by: hsa:6578
has only substance units: false
is: Q92959
type: Species
is: SBO:0000252
name: SLCO2A1
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR RE3244R
kinetic law: MODEL1310110028#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: RE3244
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#

metaM s2l2n2m2m l
is: CHEBI:30825
boundary condition: false
type: Species
name: de-Fuc form of PA6 (w/o peptide linkage)
has only substance units: false
constant: false
is: HMDB00573
initial amount: NaN
notes: FORMULA: C84H136N6O62 CHARGE: -2
is: SBO:0000247
initial concentration: 1.0

metaR PE HStm
reversible: true
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110028#
name: phosphatidylethanolamine scramblase
fast: false

metaR FACOAL226
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: fatty-acid--CoA ligase
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110028#_7c279932_8e47_4867_93f4_320af2226a65
type: Species
has only substance units: false
is: SBO:0000252
name: AKR1B1
boundary condition: true
is encoded by: hsa:231
constant: false
initial amount: NaN
initial concentration: NaN
is: P15121

metaR NMNATr
type: Reaction
reversible: true
kinetic law: MODEL1310110028#
name: nicotinamide-nucleotide adenylyltransferase
reactant: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.1
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR KCC2t
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000185
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
name: K+-Cl- cotransporter (NH4+)
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
reactant: MODEL1310110028#

metaM dolglcp U r
has only substance units: false
is: SBO:0000247
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
constant: false
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:15812

http://identifiers.org/biomodels.db/MODEL1310110028#_86672a35_07d3_4a31_92b8_df158ecd053d
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5831
constant: false
initial amount: NaN
type: Species
name: PYCR1
boundary condition: true
is: P32322
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_c4c1a1b2_2017_4715_9d96_cd2f2a1a363d
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:27068
has only substance units: false
name: PPA2
is: SBO:0000252
initial amount: NaN

metaM oaa m
is: HMDB00223
name: Oxaloacetate
initial concentration: 1.0
is: C00036
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16452
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
initial amount: NaN
constant: false

metaR HISCAT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_4a105ec4_3304_4186_a955_0f2e127296f9
boundary condition: true
name: MTMR6
constant: false
is encoded by: hsa:9107
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q9Y217

metaR RE3624M
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
reactant: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
reversible: false
name: RE3624
product: MODEL1310110028#
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_19e1a8f7_a7ad_46d6_aa80_31ac43b73f0e
has only substance units: false
is encoded by: hsa:4594
is: SBO:0000252
type: Species
name: MUT
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P22033
constant: false

metaM tdchola e
name: taurochenodeoxycholate
is: HMDB00951
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: CHEBI:9407
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

metaM thcholstoic x
constant: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: HMDB03873
initial concentration: 1.0
boundary condition: false
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM phyt c
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:37257
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00801
name: phytanate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607

metaR NDP7g
kinetic law: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
type: Reaction
reversible: false
name: nucleoside-diphosphatase (UDP), Golgi apparatus
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_a6fe88dd_386d_45b5_9a49_32cfe9491d0c
is: SBO:0000252
is encoded by: hsa:4709
initial amount: NaN
constant: false
has only substance units: false
is: Q6IB80
initial concentration: NaN
type: Species
boundary condition: true
name: NDUFB3

http://identifiers.org/biomodels.db/MODEL1310110028#_1cde2e04_d92e_4105_a833_e1efde17ca74
name: NDUFA3
boundary condition: true
is: O95167
is encoded by: hsa:4696
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR C12DCACOT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaR GLUDym
product: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
type: Reaction
name: glutamate dehydrogenase (NADP), mitochondrial
reversible: true
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.4.1.3
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:

metaR DRIBt
fast: false
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
name: deoxyribose transport via diffusion
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
modifier: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4

http://identifiers.org/biomodels.db/MODEL1310110028#_41211f01_7678_4f6d_b39d_1b32b01a93ea
constant: false
is encoded by: hsa:R06874
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _R06874_1_r

metaR r2090
modifier: MODEL1310110028#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110028#
fast: false
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM ksi deg35 l
initial amount: NaN
has only substance units: false
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
initial concentration: 1.0
is: HMDB00143
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:12936
name: keratan sulfate I, degradation product 35
constant: false

metaM hLkynr c
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: HMDB11631
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: 3-hydroxy-L-kynurenine
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:17380

http://identifiers.org/biomodels.db/MODEL1310110028#_0a3992f9_57ee_436e_a579_bc70a220c79d
initial amount: NaN
has only substance units: false
is encoded by: hsa:66035
type: Species
name: SLC2A11
is: SBO:0000252
is: Q8WXF9
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_9e883c68_41cc_49b7_81ef_c7a7bbffc896
initial amount: NaN
has only substance units: false
is: SBO:0000297
type: Species
is encoded by: hsa:515
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
boundary condition: true
initial concentration: NaN
constant: false

metaR r0845
is: SBO:0000185
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12759756,PMID:17466261,PMID:9759482 NOTES:UGLCNACtg but different compartment
kinetic law: MODEL1310110028#
type: Reaction
name: Drug/Metabolite Transporter (DMT) TCDB:2.A.7.12.7
is described by: ECO:0000000
product: MODEL1310110028#
reversible: false

metaM prostgf2 e
initial concentration: 1.0
is: CHEBI:57404
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247
constant: false
name: prostaglandin F2alpha(1-)
initial amount: NaN
is: HMDB01139
type: Species
boundary condition: false

metaM dolglcp U c
has only substance units: false
type: Species
is: CHEBI:15812
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
initial concentration: 1.0

metaR EICOSTETCPT1
kinetic law: MODEL1310110028#
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110028#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
fast: false

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:9407
name: taurochenodeoxycholate
is: SBO:0000247
has only substance units: false
is: HMDB00951
type: Species
constant: false

metaR S6TASE11ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false

metaR r0560
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110028#
fast: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reversible: false

metaM 3docopencoa m
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
boundary condition: false
name: 3,7,10,13,16-docosapentenoylcoa
constant: false
type: Species

metaR SUCOAS1m
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reactant: MODEL1310110028#
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#
name: Succinate--CoA ligase (GDP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176

metaR r2091
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR Coqe
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000134
name: Transport of q10
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
reversible: true

metaR DURIPP
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
name: deoxyuridine phosphorylase
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.3
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR

metaM so4 e
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: CHEBI:16189
initial concentration: 1.0
is: HMDB01448
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR FMNALKPle
kinetic law: MODEL1310110028#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000134
product: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: FMNALKPle
reactant: MODEL1310110028#

metaR CREATt4 2 r
reversible: true
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110028#
name: Creatine transport (sodium symport) (2:1)
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000185

metaR DITPtn
is described by: ECO:0000000
name: dITP nuclear transport
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_a420fb53_57ae_4a29_98e1_f95cdc8234c5
is encoded by: hsa:4758
has part: P16278
is encoded by: hsa:5476
initial concentration: NaN
is encoded by: hsa:2720
initial amount: NaN
boundary condition: true
type: Species
name: GALNS:GLB1:NEU1:CTSA
has part: Q99519
has only substance units: false
constant: false
is encoded by: hsa:2588
has part: P10619
is: SBO:0000297
has part: P34059

metaR RE1530C
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110028#
name: RE1530
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_1dfe9306_069d_41ef_82cc_54e4e7533e4a
boundary condition: true
initial amount: NaN
is encoded by: hsa:217
has only substance units: false
initial concentration: NaN
is: P05091
is: SBO:0000252
constant: false
name: ALDH2
type: Species

metaR SPHS1Pte
kinetic law: MODEL1310110028#
is: SBO:0000185
reversible: true
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
product: MODEL1310110028#
name: sphingosine-1-phosphate transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ

metaM phyt e
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:37257
initial amount: NaN
is: HMDB00801
type: Species
name: phytanate

metaM aacoa x
name: acetoacetyl-CoA(4-)
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
is: SBO:0000247

metaM thymd c
is: CHEBI:17748
is: C00214
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
constant: false
is: HMDB00273
name: Thymidine

metaR PMEVKx
name: phosphomevalonate kinase
kinetic law: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.2
type: Reaction
reactant: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
reversible: false
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110028#_96ea3b4e_1fa5_40d6_a2b7_6b3bff1fca91
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:5150
has only substance units: false
name: PDE7A
initial concentration: NaN
is: Q13946

metaR NACHEX18ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110028#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
modifier: MODEL1310110028#

metaR VALTAm
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
reversible: true
product: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
name: valine transaminase, mitochondiral
fast: false
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110028#

metaR PYDAMK
type: Reaction
reactant: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.35
is: SBO:0000176
product: MODEL1310110028#
fast: false
name: pyridoxamine kinase
kinetic law: MODEL1310110028#

metaR NCNt
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reversible: true
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is: SBO:0000185
name: Na+/Ca2+-NH4+ exchange
type: Reaction
is described by: ECO:0000269

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57597
boundary condition: false
name: Glycerol 3-phosphate
is: C00093
has only substance units: false
initial concentration: 1.0

metaM m6mpdol U r
type: Species
is: SBO:0000247
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:37635
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c903523e_bf30_4328_9c24_56487983e4df
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: P39877
initial concentration: NaN
is encoded by: hsa:5322
name: PLA2G5
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_cdc3d6e9_8a25_4954_9e5b_b1fb2fcd5fa4
is: P13196
boundary condition: true
name: ALAS1
initial amount: NaN
constant: false
is encoded by: hsa:211
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM coucoa m
has only substance units: false
is: SBO:0000247
is: CHEBI:57355
notes: FORMULA: C30H38N7O18P3S1 CHARGE: -4 INCHI: InChI=1S/C30H42N7O18P3S/c1-30(2,25(42)28(43)33-10-9-20(39)32-11-12-59-21(40)8-5-17-3-6-18(38)7-4-17)14-52-58(49,50)55-57(47,48)51-13-19-24(54-56(44,45)46)23(41)29(53-19)37-16-36-22-26(31)34-15-35-27(22)37/h3-8,15-16,19,23-25,29,38,41-42H,9-14H2,1-2H3,(H,32,39)(H,33,43)(H,47,48)(H,49,50)(H2,31,34,35)(H2,44,45,46)/p-4/t19-,23-,24-,25+,29-/m1/s1
initial amount: NaN
boundary condition: false
type: Species
name: 4-coumaroyl-CoA(4-)
is: C00223
initial concentration: 1.0
constant: false

metaR UDPGLCter
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
fast: false
is: SBO:0000185
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_647ec09c_e981_4dbf_b78e_5bfc88ca8031
boundary condition: true
type: Species
is: SBO:0000297
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
has only substance units: false
constant: false
has part: Q6NZ59
is encoded by: hsa:522

http://identifiers.org/biomodels.db/MODEL1310110028#_23c31583_7ab8_4fe5_baf1_6feeed146072
name: SLC22A2
is encoded by: hsa:6582
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaM eitetcoa m
constant: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
name: 5,8,11,14-eicosatetraenoylcoa
initial amount: NaN

metaM hestratriol c
constant: false
name: 4,17 dihydroxy estradiol
initial amount: NaN
notes: FORMULA: C18H24O3 CHARGE: 0 INCHI: InChI=1/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11?,12?,14?,16-,18-/m0/s1
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB05896

http://identifiers.org/biomodels.db/MODEL1310110028#_75864f57_f3a6_432f_86c8_d9f722ae4253
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: TXNRD1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7296

metaR SIAASE2ly
fast: false
is described by: ECO:0000000
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
modifier: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
kinetic law: MODEL1310110028#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_4c322df0_4834_49df_836f_77860fb0a9de
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: PRDX1
is encoded by: hsa:5052
is: SBO:0000252
type: Species

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaR C16DCe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR RE3556C
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: RE3556

metaM so4 c
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
name: sulfate
boundary condition: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR r2095
reversible: true
product: MODEL1310110028#
reactant: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110028#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000

metaM leu L e
is: HMDB00687
has only substance units: false
is: CHEBI:15603
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: L-leucine

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_675f0e25_905a_4c47_bb06_1c3d4c794004
has only substance units: false
initial concentration: NaN
type: Species
is: Q16678
boundary condition: true
is: SBO:0000252
name: CYP1B1
constant: false
is encoded by: hsa:1545
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_f941ce91_9b06_49aa_b930_628e3b93c052
name: CA6
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:765
is: Q5FC00
initial concentration: NaN
is: SBO:0000252
type: Species

metaM 25hvitd3 e
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17933
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
is: HMDB03550
name: calcidiol
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_680607ac_eb65_4c1e_a6f5_98d00220c2b7
type: Species
initial concentration: NaN
is encoded by: hsa:1215
name: CMA1
boundary condition: true
has only substance units: false
is: Q4FEB3
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_263c7a10_cadb_4b0f_b69a_f55521990b05
is: P11182
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: DBT
has only substance units: false
is encoded by: hsa:1629
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c91aaef7_0df8_403c_af6b_6f64b3f73d29
initial concentration: NaN
has part: Q9UHI5
has only substance units: false
name: SLC7A8:SLC3A2
is: SBO:0000297
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:23428
type: Species

metaM 4mop c
name: 4-methyl-2-oxopentanoate
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17865
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_3a2bbe08_10a5_4c60_a191_81382f080c9c
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q6IBC0
is encoded by: hsa:3155
constant: false
is: SBO:0000252
name: HMGCL
boundary condition: true
type: Species

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR FAOXC164m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR LINKDEG4ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
type: Reaction
is described by: ECO:0000000

metaM xoldiolone r
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:28477
is: HMDB02197
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

metaR r2096
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
reversible: true
product: MODEL1310110028#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_408276c5_e35a_4f82_a6e7_96dace01fe8e
is: SBO:0000252
is encoded by: hsa:2224
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: FDPS
is: P14324

metaM oaa c
has only substance units: false
is: C00036
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00223
notes: FORMULA: C4H2O5 CHARGE: -2
boundary condition: false
name: Oxaloacetate
is: CHEBI:3338
is: SBO:0000247
constant: false

metaM ttdca c
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: CHEBI:30807
name: myristate
is: HMDB00806

metaR NDPK8n
modifier: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#
is: SBO:0000176
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

metaM leu L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687
is: CHEBI:15603
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: L-leucine
has only substance units: false
initial amount: NaN

metaM 3hibutcoa m
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: (S)-3-Hydroxyisobutyryl-CoA
boundary condition: false
constant: false
is: CHEBI:28259
has only substance units: false
is: HMDB01052
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000

metaR r0410
type: Reaction
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reversible: true
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110028#

metaM 25hvitd3 c
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:17933
initial amount: NaN
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
name: calcidiol
is: HMDB03550
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM glyc R c
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16659
is: HMDB00139
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate

metaR r2092
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_05df8e29_74db_4389_9ed5_5665775083ca
initial concentration: NaN
constant: false
name: _AI972237_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AI972237
initial amount: NaN

metaM 4mop e
boundary condition: false
name: 4-methyl-2-oxopentanoate
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: CHEBI:17865
is: HMDB00695
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_bdf5849a_8eef_47b2_a40d_e8f981bb4e49
is: B7Z4Y6
initial amount: NaN
is encoded by: hsa:249
boundary condition: true
name: ALPL
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_d6d99caf_3d0c_4011_ae0e_31b28558bd24
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23761
has only substance units: false
boundary condition: true
is: Q9UG56
type: Species
is: SBO:0000252
name: PISD
constant: false

metaR DUDPtn
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
name: dUDP nuclear transport

metaR r2094
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM sgalside hs c
is: HMDB03406
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:16523
name: sulfatide galactocerebroside
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR AMPDA
is version of: http://identifiers.org/ec-code/3.5.4.6
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110028#
reversible: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
name: Adenosine monophosphate deaminase

metaR r2093
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110028#
fast: false
is: SBO:0000185

metaM ttdca e
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C06424
is: CHEBI:30807
constant: false
is: HMDB00806
type: Species
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
boundary condition: false
name: tetradecanoate (n-C14:0)

http://identifiers.org/biomodels.db/MODEL1310110028#_dd2ad173_5835_4a4e_a395_ed99a7ec6495
initial concentration: NaN
is encoded by: hsa:53354
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: PANK1
type: Species
is: SBO:0000252

metaR HEDCECRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaR SLDx
is described by: ECO:0000304
name: L-sulfolactate dehydrogenase (NAD+)
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272
reversible: true
modifier: MODEL1310110028#
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaM camp c
notes: FORMULA: C10H11N5O6P CHARGE: -1 INCHI: InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00434 EHMN_ABBREVIATION: C00575
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 3',5'-cyclic AMP(1-)
is: CHEBI:58165
type: Species
constant: false
is: HMDB00058
initial concentration: 1.0
boundary condition: false

metaR FAOXC163x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_b42add14_630a_4e4c_861c_fdee8fae8b66
is: Q9Y2Q0
constant: false
is encoded by: hsa:10396
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: ATP8A1
boundary condition: true

metaM so4 m
boundary condition: false
initial amount: NaN
name: sulfate
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB01448
is: SBO:0000247

metaM ser L e
boundary condition: false
is: CHEBI:17115
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00187
name: L-serine
constant: false

metaM acnamp c
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: N-Acetylneuraminate 9-phosphate
has only substance units: false
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
is: HMDB06268
type: Species
is: CHEBI:27438

http://identifiers.org/biomodels.db/MODEL1310110028#_bf87c14f_da02_4802_95a3_d280df50e8bd
is encoded by: hsa:57171
boundary condition: true
has only substance units: false
is: Q86YN1
type: Species
constant: false
name: DOLPP1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR RE0453N
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_a36ff2c5_5857_4b13_bc26_bcee13872b74
is encoded by: hsa:29988
type: Species
initial amount: NaN
is: Q9NY64
constant: false
has only substance units: false
boundary condition: true
name: SLC2A8
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_1258618c_4b86_4472_b272_c10ae9fac3ba
name: ABAT
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:18

metaM xol7aone m
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaR FAOXC1811603m
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: Beta oxidation fatty acid
type: Reaction

metaR r2099
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110028#
fast: false
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110028#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_95e7cba4_c646_402b_a6eb_f84540ca0392
is: SBO:0000252
is: P09960
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4048
boundary condition: true
initial concentration: NaN
has only substance units: false
name: LTA4H

metaR RE0453M
is described by: ECO:0000000
type: Reaction
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
kinetic law: MODEL1310110028#
name: RE0453
reversible: true
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_6b3cf380_f8e1_40df_8d87_8956c9272388
boundary condition: true
constant: false
is: C5HZ13
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1178
has only substance units: false
type: Species
name: CLC
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_575a9525_b31a_48f0_8cc8_0175ef3ddf11
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:51227
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: PIGP

metaM hcys L c
initial concentration: 1.0
is: HMDB00742
name: L-homocysteine
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: CHEBI:17588
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_31c473ff_40a2_4ff1_8903_07a41e1bbad8
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
constant: false
is: SBO:0000297
initial concentration: NaN
boundary condition: true
has part: Q06055
has only substance units: false
is encoded by: hsa:517
initial amount: NaN
type: Species

metaM pacald c
type: Species
constant: false
name: phenylacetaldehyde
has only substance units: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial concentration: 1.0
initial amount: NaN
is: HMDB06236
is: CHEBI:16424
is: SBO:0000247
boundary condition: false

metaR r2098
modifier: MODEL1310110028#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM pail hs n
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:57880
constant: false
is: SBO:0000247

metaM oxa c
is: SBO:0000247
type: Species
is: CHEBI:30623
initial amount: NaN
initial concentration: 1.0
name: oxalate(2-)
is: HMDB02329
constant: false
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false

metaM so4 l
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
type: Species
is: CHEBI:16189
constant: false
is: HMDB01448
name: sulfate
is: SBO:0000247

metaM chito2pdol U c
boundary condition: false
initial amount: NaN
is: CHEBI:12427
constant: false
initial concentration: 1.0
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
has only substance units: false
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
type: Species

metaR FAOXC102C81x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaM c101coa c
type: Species
name: decenoylcoa
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: HMDB00651
constant: false
has only substance units: false

metaR GLUPRT
name: glutamine phosphoribosyldiphosphate amidotransferase
is version of: http://identifiers.org/ec-code/2.4.2.14
reversible: false
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_82826acd_b58e_4d62_acc6_d187f3934121
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: NDUFV3
is: SBO:0000252
is: P56181
initial amount: NaN
is encoded by: hsa:4731

metaR FAOXC15ATPx
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

metaR FAOXC226C205m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_d51a9a13_578d_4cbf_a3bd_6b3433deb532
initial amount: NaN
is encoded by: hsa:2530
initial concentration: NaN
is: B4DFS7
has only substance units: false
type: Species
name: FUT8
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_72ec56a9_71fc_44d9_8efd_a812cb09c0b3
is: Q9P109
constant: false
is encoded by: hsa:51301
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GCNT4
has only substance units: false

metaR C6DCc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaR r2097
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a71adb96_0eac_408b_a9e1_c025e2775e10
initial concentration: NaN
name: PDE6A:PDE6H:PDE6B
boundary condition: true
type: Species
is: SBO:0000297
has only substance units: false
is encoded by: hsa:5149
constant: false
has part: P16499
has part: Q13956
is encoded by: hsa:5158
initial amount: NaN
is encoded by: hsa:5145
has part: B7Z9T9

metaM 35cgmp n
initial concentration: 1.0
is: CHEBI:57746
is: HMDB01314
initial amount: NaN
constant: false
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: SBO:0000247
type: Species
name: 3',5'-cyclic GMP(1-)
boundary condition: false
has only substance units: false

metaR C16DCc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_bb0cfba0_2a68_462c_863d_48a4fa3c809c
has part: A0PJH2
has part: P46459
has part: O75964
boundary condition: true
type: Species
is encoded by: hsa:10476
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:516
is encoded by: hsa:521
is encoded by: hsa:515
has part: P05496
is encoded by: hsa:4905
is: SBO:0000297
has part: Q08ET0
is encoded by: hsa:522
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: P56385
is encoded by: hsa:10632
is encoded by: hsa:9551
has part: Q6IBB3

metaM tetpent6 c
constant: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
has only substance units: false
is: HMDB06322
initial concentration: 1.0
name: tetracosapentaenoic acid, n-6
initial amount: NaN

metaM dopa c
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:59905
boundary condition: false
is: HMDB00073
type: Species
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial concentration: 1.0
has only substance units: false
name: dopaminium(1+)

metaM ksii core4 pre4 g
initial amount: NaN
initial concentration: 1.0
is: HMDB00175
constant: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
type: Species
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 4
is: CHEBI:58053
is: SBO:0000247
is: C00130
boundary condition: false

metaM abt e
initial amount: NaN
constant: false
is: CHEBI:18403
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol
is: HMDB01851
initial concentration: 1.0
boundary condition: false
type: Species

metaR SLDt
name: L-sulfolactate transport (cytosol to extracellular)
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM

metaM etfox m
is: SBO:0000247
is: CHEBI:16469
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: R CHARGE: 0
name: Electron transfer flavoprotein oxidized
has only substance units: false
is: HMDB00151
type: Species
boundary condition: false
constant: false

metaR UAGDP
product: MODEL1310110028#
name: UDP-N-acetylglucosamine diphosphorylase
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.23
reactant: MODEL1310110028#

metaM c101crn e
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: decenoyl carnitine
has only substance units: false
is: HMDB13205
notes: FORMULA: C17H31NO4 CHARGE: 0
type: Species
initial concentration: 1.0

metaR G14T9g
fast: false
reactant: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false

metaM gdpfuc g
is: CHEBI:57984
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01095
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
boundary condition: false
name: GDP-L-fucose(2-)
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_6a563438_052c_4a44_9e13_92461683734f
name: ACOT7
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: O00154
has only substance units: false
type: Species
is encoded by: hsa:11332

http://identifiers.org/biomodels.db/MODEL1310110028#_7f38e10d_0047_48d5_9494_3c9753deae14
constant: false
is: O43674
type: Species
initial amount: NaN
initial concentration: NaN
name: NDUFB5
boundary condition: true
has only substance units: false
is encoded by: hsa:4711
is: SBO:0000252

metaR r1682
fast: false
modifier: MODEL1310110028#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110028#
reversible: false
is: SBO:0000185
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
type: Reaction
is described by: ECO:0000000

metaM aacoa c
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: C00332
initial concentration: 1.0
name: Acetoacetyl-CoA
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:57286
is: SBO:0000247
is: HMDB01484

metaM tdchola x
is: CHEBI:9407
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00951
has only substance units: false
constant: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
name: taurochenodeoxycholate
initial concentration: 1.0
initial amount: NaN

metaM 4h2oglt m
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: HMDB02070
is: SBO:0000247
boundary condition: false
name: 4-hydroxy-2-oxoglutarate(2-)
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:17742

metaM oxa e
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: SBO:0000247
boundary condition: false
name: oxalate(2-)
constant: false
is: HMDB02329
initial concentration: 1.0
type: Species
is: CHEBI:30623
has only substance units: false

metaR FAOXC12C10x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ed2459a2_aeb3_4222_8572_e107628d7fa0
boundary condition: true
is: SBO:0000297
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:7991
has only substance units: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3

metaR FAOXC226C227m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaM 2dp6mep m
constant: false
type: Species
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
name: 2-Decaprenyl-6-methoxyphenol
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:50774
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_e4e4cc1f_b9e0_479f_8712_3a8e7bdc7e7a
constant: false
is encoded by: hsa:7360
boundary condition: true
type: Species
initial concentration: NaN
name: UGP2
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q16851

metaR MG3er
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000

metaR KSItly
is: SBO:0000185
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110028#
name: keratan sulfate I transport, extracellular to lysosome

metaM octd11ecoa m
boundary condition: false
is: HMDB06294
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
name: 11-octadecenoylcoa
has only substance units: false
is: SBO:0000247

metaR S2TASE2ly
type: Reaction
kinetic law: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
modifier: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD

metaM cmpacna c
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB01176
is: CHEBI:57812

metaM abt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01851
is: CHEBI:18403
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaR DOLMANP Uter
kinetic law: MODEL1310110028#
is: SBO:0000185
name: dolichol-phosphate mannose flippase (uterus)
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110028#
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction

metaM c101crn c
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: decenoyl carnitine
has only substance units: false
notes: FORMULA: C17H31NO4 CHARGE: 0
initial concentration: 1.0
type: Species
is: HMDB13205

metaM paps c
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
boundary condition: false
constant: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: HMDB01134
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:58339

http://identifiers.org/biomodels.db/MODEL1310110028#_a9be3680_80ff_4abc_9021_f03a849e682e
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:NM 013421
type: Species
name: _NM_013421_1_m
constant: false
initial amount: NaN

metaR ALOX52
modifier: MODEL1310110028#
is: SBO:0000176
fast: false
name: Arachidonate 5-lipoxygenase
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.34
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
is described by: ECO:0000269
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_78a8e0e4_b823_43a6_8234_ee900e811e13
has only substance units: false
is: Q9NS00
boundary condition: true
is encoded by: hsa:56913
is: SBO:0000252
initial amount: NaN
name: C1GALT1
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c5b33699_6d39_4499_931c_0d29feba4da2
has only substance units: false
is encoded by: hsa:R39999
is: SBO:0000252
constant: false
type: Species
name: _R39999_1_c
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM HC02023 r
name: Cholesterol-ester-ol
constant: false
boundary condition: false
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:46898
is: SBO:0000247

metaR GALtly
kinetic law: MODEL1310110028#
fast: false
reversible: false
type: Reaction
name: galactose efflux from lysosome
product: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185

metaM od2coa m
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h18-19,26-28,32-34,38,49-50H,4-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b19-18+/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE2244
name: trans-Octadec-2-enoyl-CoA
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:50570
is: HMDB06529
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR AG13T13g
reversible: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110028#
fast: false

metaR FOLt2le
name: folate transport via anion exchange
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110028#

metaR LTD4DP
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: Leukotriene D4 dipeptidase
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
product: MODEL1310110028#

metaR RETt
is: SBO:0000185
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110028#
name: Retinol transport via faciliated diffusion
product: MODEL1310110028#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_2edfc75d_d0ce_47be_bff3_5f5f178cb1e5
initial amount: NaN
constant: false
is encoded by: hsa:29920
is: SBO:0000252
is: Q96C36
type: Species
boundary condition: true
name: PYCR2
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_eed50c8d_4117_4a3d_adc1_02d6b1d92ab3
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:4830
boundary condition: true
constant: false
initial concentration: NaN
name: NME1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_3896098c_f75b_44d4_ab77_5d99fcafa436
constant: false
type: Species
has only substance units: false
is encoded by: hsa:93010
initial concentration: NaN
name: B3GNT7
boundary condition: true
is: Q8NFL0
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_08067abc_5b6c_49f8_97d2_1d2c985e7c11
boundary condition: true
is encoded by: hsa:2687
name: GGT5
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is: P36269
initial concentration: NaN

metaM cs b l
type: Species
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
is: SBO:0000247
is: CHEBI:36005
constant: false
initial amount: NaN
is: HMDB02183

metaM 2mb2coa c
constant: false
is: HMDB02054
is: SBO:0000247
type: Species
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 2-methylcrotonoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110028#_ffc580db_42b6_4f52_98ae_8f108a3d1751
boundary condition: true
is encoded by: hsa:1716
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: DGUOK
constant: false

metaR FAOXC184C163x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR EICOSTETCPT2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
product: MODEL1310110028#
name: carnitine transferase
reversible: false
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction

metaM 13 cis retn r
name: 13-cis-retinoate
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: D00348
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/7847414
is: SBO:0000247
boundary condition: false
is: HMDB06219

metaM emgacpail hs r
constant: false
is: CHEBI:16038
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H74N2O22P2FULLRCO2FULLR2CO2 CHARGE: 0
name: phosphoethanolaminyl-mannosyl-glucosylaminyl-acylphosphatidylinositol (H5)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_c8bd38b6_3a3f_4e90_ae50_8f3ee345ab3c
has only substance units: false
initial concentration: NaN
name: ADCY3
is: B3KT86
initial amount: NaN
constant: false
is encoded by: hsa:109
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_ef748d83_8973_44ed_99e4_caf5f4763d81
initial amount: NaN
has only substance units: false
name: ST3GAL3
is encoded by: hsa:6487
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species

metaR ACNAMlt
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
name: N-acetylneuraminate transport into lysososme
reversible: true
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
modifier: MODEL1310110028#

metaR ADK3m
name: adentylate kinase (GTP)
is described by: ECO:0000269
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.10
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ce1a6aec_70f7_4c5f_b827_a37ae22bf1ac
initial concentration: NaN
name: NME1
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:4830
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_f18c931d_6576_4d8c_b397_0d07f179fe76
is: Q9UIG8
type: Species
initial concentration: NaN
is encoded by: hsa:28232
is: SBO:0000252
name: SLCO3A1
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaM 2mb2coa m
name: 2-methylcrotonoyl-CoA(4-)
is: CHEBI:57337
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
is: HMDB02054
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species

metaR GALASE6ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110028#
is: SBO:0000176

metaM ksi deg34 l
type: Species
name: keratan sulfate I, degradation product 34
initial concentration: 1.0
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
is: CHEBI:57455
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01354

metaM ethamp r
name: O-phosphonatoethanaminium(1-)
boundary condition: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00224
constant: false
has only substance units: false
is: CHEBI:58190

metaR IDPtn
is described by: ECO:0000000
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
name: IDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR GLCter
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_db23dbc8_7a2e_47ab_86fb_3aa7bd39fcc4
type: Species
is: P37837
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6888
name: TALDO1
initial concentration: NaN
has only substance units: false

metaM hdd2coa c
type: Species
initial concentration: 1.0
is: CHEBI:61526
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
name: trans-Hexadec-2-enoyl-CoA
is: SBO:0000247
is: HMDB03945
initial amount: NaN
is: C05272

metaR GLNS
reversible: false
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: glutamine synthetase
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.15
type: Reaction

metaR MALTSULtm
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
fast: false
product: MODEL1310110028#
reversible: true
name: Malate:thiosulfate antiport, mitochondrial

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_66753844_2b5d_4af1_91de_7175e960b3d6
is: P31645
boundary condition: true
is encoded by: hsa:6532
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: SLC6A4

metaR S6T6g
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110028#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110028#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110028#

metaM HC01401 m
is: CHEBI:27668
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_ba054fa9_73d3_47d4_b83e_0a1109d48b9e
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:123041
initial amount: NaN
boundary condition: true
name: SLC24A4
initial concentration: NaN
type: Species

metaM cmpacna g
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
is: HMDB01176
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR AICART
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
fast: false
reversible: true
reactant: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
is described by: ECO:0000269
modifier: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.3
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_3c7d7d0e_8024_4fff_97c9_6ee55150f103
is encoded by: hsa:27235
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: COQ2
is: Q96H96
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR G3PD1
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
name: glycerol-3-phosphate dehydrogenase (NAD)
is described by: ECO:0000269
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.8

metaM paps g
is: SBO:0000247
initial concentration: 1.0
constant: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
type: Species
has only substance units: false
is: HMDB01134
initial amount: NaN
boundary condition: false
is: CHEBI:58339
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaR NACHEX19ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000176
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal

metaM tetpent6 e
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06322
is: SBO:0000247
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
name: tetracosapentaenoic acid, n-6
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_d0e3a66e_3a50_4797_a9ef_c6eb0e679e16
has only substance units: false
is: O15254
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: ACOX3
is encoded by: hsa:8310
boundary condition: true

metaR MDHm
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37
reversible: true
fast: false
kinetic law: MODEL1310110028#
type: Reaction
name: malate dehydrogenase, mitochondrial
product: MODEL1310110028#
reactant: MODEL1310110028#

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_e6d620ef_ddc3_4771_a10d_c6174c4c238a
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:57835
name: SLC4A5
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_4cbfdde0_1159_4d78_a61f_95e7756b54be
constant: false
has only substance units: false
name: SLC35D1
initial amount: NaN
is encoded by: hsa:23169
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q9NTN3

http://identifiers.org/biomodels.db/MODEL1310110028#_2720d074_e4e2_49a5_b14a_2d61620229a6
constant: false
is: Q8IWX5
is: SBO:0000252
is encoded by: hsa:130367
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: SGPP2

http://identifiers.org/biomodels.db/MODEL1310110028#_9d180ead_7794_4672_9354_f4b45dff4f39
is: P14672
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
name: SLC2A4
is encoded by: hsa:6517

metaR HIStiDF
reactant: MODEL1310110028#
name: L-histidine transport via diffusion (extracellular to cytosol)
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
type: Reaction
modifier: MODEL1310110028#
is described by: ECO:0000269
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB

metaR r1252
reversible: false
reactant: MODEL1310110028#
is described by: ECO:0000000
name: EC:6.2.1.3
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110028#

metaR GCHOLAte
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
reactant: MODEL1310110028#
reversible: true

metaR FAOXC161802m
product: MODEL1310110028#
is: SBO:0000176
name: Beta oxidation fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_22956f37_04bd_460d_a1c9_384cf97b434c
initial concentration: NaN
initial amount: NaN
name: NME1:NME2
has only substance units: false
is: SBO:0000297
boundary condition: true
constant: false
type: Species
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110028#_b20c7af1_8a11_4beb_adef_4111c5b664d6
name: _BE966236_1_m
has only substance units: false
initial concentration: NaN
is encoded by: hsa:BE966236
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR RE2625M
fast: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
name: RE2625
reactant: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
is: SBO:0000176

metaM xol7aone r
initial concentration: 1.0
constant: false
is: HMDB01993
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
type: Species
is: CHEBI:17899
initial amount: NaN
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_4680bce3_c607_4580_8990_36d5c2965172
has only substance units: false
is: P11168
constant: false
name: SLC2A2
boundary condition: true
is encoded by: hsa:6514
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_ba03d636_ef82_47f8_bec2_9a606323d9e5
boundary condition: true
initial amount: NaN
name: MIA3
is: SBO:0000252
is: Q5JRA6
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:375056
has only substance units: false

metaM od2coa c
initial concentration: 1.0
name: trans-Octadec-2-enoyl-CoA
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
is: SBO:0000247
type: Species
is: CHEBI:50570
boundary condition: false
has only substance units: false
is: C16218
is: HMDB06529
initial amount: NaN

metaM gthox m
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB03337
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297

metaR H2Otly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110028#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110028#
name: H2O transport, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110028#

metaM xoldiolone c
is: HMDB02197
initial amount: NaN
initial concentration: 1.0
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: CHEBI:28477
has only substance units: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
constant: false
is: SBO:0000247
boundary condition: false
type: Species

metaM pail hs c
constant: false
boundary condition: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: SBO:0000247
is: CHEBI:57880
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r0860
modifier: MODEL1310110028#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
name: Utilized transport
reversible: true
reactant: MODEL1310110028#
fast: false

metaR RE2426C
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
fast: false
name: RE2426
is: SBO:0000176
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:

metaR ITCOAL1m
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
product: MODEL1310110028#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110028#_f05b317e_660b_424f_9273_0d28f062a56b
initial amount: NaN
is encoded by: hsa:847
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: CAT
type: Species
is: P04040
is: SBO:0000252

metaM ser L c
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
is: CHEBI:17115
is: HMDB00187
name: L-serine
is: SBO:0000247

metaR NACHEX26ly
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110028#
reversible: false
is described by: ECO:0000000

metaR ADPCOAPTE
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_9b043f3b_fa2c_40bb_90f1_f705085913d8
is: O95169
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: NDUFB8
initial amount: NaN
has only substance units: false
is encoded by: hsa:4714
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_65b2b09d_eef5_4fc5_bba9_b5ed4d48b76b
is: P15954
is: SBO:0000252
is encoded by: hsa:1350
has only substance units: false
name: COX7C
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaM cs a l
boundary condition: false
initial concentration: 1.0
is: HMDB02183
type: Species
is: CHEBI:36005
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain

metaM aacoa m
is: HMDB01484
type: Species
initial concentration: 1.0
is: CHEBI:57286
has only substance units: false
boundary condition: false
is: SBO:0000247
name: acetoacetyl-CoA(4-)
constant: false
initial amount: NaN
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaM HC01434 m
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
type: Species
initial concentration: 1.0
is: CHEBI:58931
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
name: oxalatosuccinate(3-)

metaR FAOXC183C163Gm
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_2c08032a_906a_45db_a195_fa4a94ef8f1c
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4704
type: Species
initial amount: NaN
is: Q16795
name: NDUFA9
constant: false

metaM hs deg10 l
is: CHEBI:15748
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 10
type: Species
is: HMDB00127
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
boundary condition: false
constant: false
initial amount: NaN

metaM inost c
boundary condition: false
type: Species
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
constant: false
initial amount: NaN
is: CHEBI:17268
has only substance units: false
is: HMDB00211
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_ac552d17_4cbd_4c3e_b349_7cc849d068f6
has only substance units: false
name: PYCR1
is: A6NFM2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5831
boundary condition: true
constant: false
type: Species

metaM inost e
constant: false
is: CHEBI:17268
is: HMDB00211
name: myo-inositol
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaM andrstandn r
is: CHEBI:15994
constant: false
initial concentration: 1.0
is: HMDB00899
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
has only substance units: false
type: Species
name: 5alpha-androstane-3,17-dione
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR RE0453C
reversible: true
name: RE0453
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_e1b878f9_7161_4512_8bc0_f56268d2dcfe
is encoded by: hsa:515
name: ATP5F1
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM ocdca c
is: CHEBI:25629
name: stearate
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: HMDB00827
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_f526428d_42ea_4a38_ba3d_955b05e2c31d
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10587
name: TXNRD2
initial amount: NaN
constant: false

metaM octd11ecoa c
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280771
boundary condition: false
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
name: 11-octadecenoylcoa
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_98ad3b6f_96a2_46bf_bd96_0abc29a13692
name: CYP51A1
is: SBO:0000252
is: Q16850
constant: false
has only substance units: false
is encoded by: hsa:1595
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species

metaR r0579
reactant: MODEL1310110028#
reversible: true
product: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.19

http://identifiers.org/biomodels.db/MODEL1310110028#_a8140e7b_728c_4f33_b777_4d3f888d5558
is encoded by: hsa:285973
is: SBO:0000252
constant: false
is: Q674R7
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ATG9B

metaM h2o2 n
initial amount: NaN
constant: false
name: hydrogen peroxide
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
is: CHEBI:16240
type: Species
is: HMDB03125
boundary condition: false
initial concentration: 1.0

metaR CSm
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
fast: false
name: citrate synthase
is version of: http://identifiers.org/ec-code/2.3.3.1
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_c10ba02e_bbe4_4b3a_8e9d_a194785ae894
has only substance units: false
is: Q9BW60
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:64834
type: Species
constant: false
name: ELOVL1

metaR CITL
kinetic law: MODEL1310110028#
name: Citrate lyase
reversible: false
modifier: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR FAOXC184C164m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR r0578
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110028#
reversible: true
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_bd2a3d5d_4322_44b9_8e3a_eaae9b024703
is encoded by: hsa:23236
initial amount: NaN
is: SBO:0000252
name: PLCB1
constant: false
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: Q9NQ66

http://identifiers.org/biomodels.db/MODEL1310110028#_dec84061_7f63_464a_885c_d2916cadd280
is: Q7LG56
constant: false
type: Species
is: SBO:0000252
name: RRM2B
initial amount: NaN
has only substance units: false
is encoded by: hsa:50484
boundary condition: true
initial concentration: NaN

metaM acmanap c
initial amount: NaN
name: N-acetyl-D-mannosamine 6-phosphate(2-)
is: SBO:0000247
is: HMDB01121
constant: false
is: CHEBI:58557
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
boundary condition: false

metaR PUNP5
name: purine-nucleoside phosphorylase (Inosine)
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction

metaM h2o2 m
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16240
type: Species
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: C00027
is: HMDB03125
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_4828969d_29a0_4416_a68e_85fe296caf45
initial amount: NaN
boundary condition: true
is encoded by: hsa:9334
is: O43286
name: B4GALT5
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_092e88fb_3c5b_426a_82c1_301617d28923
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:509
name: ATP5C1
initial concentration: NaN
is: Q6I9V2
has only substance units: false
is: SBO:0000252

metaM 3sala c
initial concentration: 1.0
type: Species
name: 3-Sulfino-L-alanine
is: CHEBI:61085
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: SBO:0000247
boundary condition: false
constant: false
is: C00606

metaR 2AMACHYD
kinetic law: MODEL1310110028#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
fast: false
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
name: 2-Aminoacrylate hydrolysis
is described by: ECO:0000000

metaM hdd2coa m
boundary condition: false
is: HMDB03945
has only substance units: false
initial amount: NaN
is: CHEBI:61526
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: SBO:0000247
type: Species
name: trans-Hexadec-2-enoyl-CoA
is: C05272
constant: false

metaR NRVNCCOAtx
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: fatty acid intracellular transport
reversible: true
is: SBO:0000185

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR UMPK5n
is described by: ECO:0000269
name: UMP kinase (dATP),nuclear
is: SBO:0000176
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#

metaM ptth c
is: SBO:0000247
constant: false
type: Species
boundary condition: false
name: pantetheine
initial amount: NaN
is: HMDB03426
is: CHEBI:16753
has only substance units: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0

metaR PI345P3P
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110028#
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.67
type: Reaction
is described by: ECO:0000000
product: MODEL1310110028#
modifier: MODEL1310110028#

metaM hdcecrn m
has only substance units: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
initial amount: NaN
is: HMDB00222
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
name: Hexadecenoyl carnitine

metaR PUNP4
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
kinetic law: MODEL1310110028#
name: purine-nucleoside phosphorylase (Deoxyguanosine)
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110028#

metaM nadh c
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00004
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
constant: false
type: Species

metaM CE2433 m
constant: false
boundary condition: false
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57795
initial concentration: 1.0
is: SBO:0000247

metaR MAL Lte
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110028#
name: Transport of L-malate
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000134

metaM ksi deg13 l
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
name: keratan sulfate I, degradation product 13
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01354
type: Species
boundary condition: false
is: CHEBI:57455
is: SBO:0000247
has only substance units: false

metaR RE3243R
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
name: RE3243

metaR PROSTGI2t
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110028#
is: SBO:0000185
name: Prostaglandin I2 transport
type: Reaction
fast: false

metaR MM5ag
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
product: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaR HPCLx
is described by: ECO:0000269
fast: false
modifier: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
is: SBO:0000176
type: Reaction
name: 2-hydroxyphytanoyl-CoA lyase
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (26062.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10468558 NOTES:pristanal is the fatty aldehyde analog of pristanic acid Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. NJ
kinetic law: MODEL1310110028#

metaM o2 c
type: Species
boundary condition: false
name: O2
is: CHEBI:15379
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
is: HMDB01377
is: SBO:0000247
constant: false
is: C00007
initial amount: NaN

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
product: MODEL1310110028#
reactant: MODEL1310110028#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110028#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110028#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_33a9ff2c_b9ef_45f8_8d15_6880a939b6fc
initial concentration: NaN
is encoded by: hsa:2509
type: Species
name: _2509_1_e
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaR PUNP3
modifier: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110028#
name: purine-nucleoside phosphorylase (Guanosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
fast: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
reactant: MODEL1310110028#

metaR HS3ly
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1
reversible: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110028#_cbe2d3f3_dcb4_46c2_98d8_b2d77a50a05c
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: ACAT2
is: Q9BWD1
is encoded by: hsa:39
initial concentration: NaN
constant: false
is: SBO:0000252

metaM gthox c
boundary condition: false
is: CHEBI:58297
has only substance units: false
constant: false
name: Oxidized glutathione
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00127
is: HMDB03337

http://identifiers.org/biomodels.db/MODEL1310110028#_4c503874_b928_4294_bca0_0169c89f8f36
initial amount: NaN
constant: false
name: FTH1
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2495
is: SBO:0000252
is: P02794

metaM 3ohdcoa x
name: 3-oxopalmitoyl-CoA(4-)
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB06402
has only substance units: false
is: CHEBI:57349

http://identifiers.org/biomodels.db/MODEL1310110028#_17bcb11d_d70d_4b2e_aadf_a10204a45e08
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: Q9UHI7
name: SLC23A1
type: Species
initial amount: NaN
is encoded by: hsa:9963
boundary condition: true

metaM arachd l
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32395
boundary condition: false
is: SBO:0000247
name: arachidonate
constant: false
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219

metaR PEROXx
name: peroxisomal lumped long chain fatty acid oxidation
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
kinetic law: MODEL1310110028#

metaM HC02214 e
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-f1alpha
type: Species
is: CHEBI:28852
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
is: SBO:0000247
boundary condition: false
constant: false

metaR ILEtec
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
name: L-isoleucine transport via diffusion (extracellular to cytosol)
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_2af22f8e_f749_4d60_bb2c_4f3681549a74
boundary condition: true
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
type: Species
has part: Q13733
is encoded by: hsa:480
has only substance units: false
name: ATP1A4:ATP1B1
constant: false

metaM msa m
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 3-oxopropanoate
type: Species
is: HMDB11111
is: CHEBI:33190
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222

http://identifiers.org/biomodels.db/MODEL1310110028#_88519031_cb1a_4269_94a7_979483430449
initial amount: NaN
is encoded by: hsa:34
is: P11310
boundary condition: true
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: ACADM

metaR C180CPT1
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110028#
name: production of stearoylcarnitine

metaR FACOAL140i
is: SBO:0000176
reactant: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
is described by: ECO:0000269
product: MODEL1310110028#
name: fatty-acid--CoA ligase (tetradecanoate)
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
fast: false

metaR O2Stx
is: SBO:0000185
name: superoxide anion transport via diffusion (peroxisome)
type: Reaction
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110028#

metaR S6TASE12ly
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110028#
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR r0575
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110028#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110028#

metaR COAtr
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
is described by: ECO:0000000
reactant: MODEL1310110028#
name: COA transporter, endoplasmic reticulum
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_4d47495d_7d86_43cf_804d_8aa988632887
boundary condition: true
is: Q9ULD0
name: OGDHL
is encoded by: hsa:55753
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR O2t
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000185
name: o2 transport (diffusion)
reversible: true
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD

metaM m6masnC g
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: CHEBI:30825
is: HMDB00573
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR RE1135C
is described by: ECO:0000000
product: MODEL1310110028#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.2
name: RE1135
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:

metaR C180CPT2
name: carnitine O-stearoyl transferase
is described by: ECO:0000269
modifier: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_0e3b50c5_1bbf_4d6e_8858_9811e986260b
constant: false
boundary condition: true
initial concentration: NaN
name: NDUFS4
is: O43181
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:4724
is: SBO:0000252

metaM 3ttetddcoacrn c
notes: FORMULA: C21H37NO5 CHARGE: 0
initial amount: NaN
type: Species
is: HMDB02014
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_c8d603e4_5ab5_42bf_9401_1e1818bb4bd0
constant: false
is: Q9Y2B2
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:9487
name: PIGL
boundary condition: true
is: SBO:0000252

metaR TMNDNCt
name: fatty acid transport via diffusion
is described by: ECO:0000000
product: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
kinetic law: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a508b003_87cd_4f8e_b4f3_842212be2a7a
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5151
name: PDE8A
type: Species
is: H0YMZ7
constant: false

metaR PIter
name: phosphate transport, endoplasmic reticulum
product: MODEL1310110028#
fast: false
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
reversible: true
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_d8882a46_923c_4eaa_a2c2_72e809c1026f
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PLA2G4A
is encoded by: hsa:5321
constant: false
type: Species
is: P47712
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_bf9a3ccd_98bd_4e09_9b9e_802d5baa80cf
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: P49189
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:223
name: ALDH9A1

http://identifiers.org/biomodels.db/MODEL1310110028#_85ceb1dc_49c0_4ec2_87fe_9780bc6affd0
is encoded by: hsa:2990
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: GUSB
is: P08236
is: SBO:0000252

metaR DDECCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaM q10 c
name: ubiquinone-10
has only substance units: false
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01072
initial concentration: 1.0
constant: false
is: CHEBI:46245

metaR H6MTer L
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (80235.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15208306 NOTES:NCD
kinetic law: MODEL1310110028#
fast: false
name: H6 mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000

metaR O2St
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110028#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
name: superoxide anion transport via diffusion (extracellular)
is described by: ECO:0000000

metaR COAtp
reactant: MODEL1310110028#
name: coenzyme A transport, peroxisomal
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_0c2c1e08_7df4_4ba1_8cbc_1c9f97c02d33
name: NOS1
constant: false
type: Species
is: B4DG68
is encoded by: hsa:4842
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR TPI
modifier: MODEL1310110028#
is: SBO:0000176
name: triose-phosphate isomerase
is version of: http://identifiers.org/ec-code/5.3.1.1
reversible: true
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
fast: false
is described by: ECO:0000134

metaR r0830
product: MODEL1310110028#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_2bffd550_74bd_4e0f_80aa_53e7bc9e8ccc
is encoded by: hsa:7389
is: P06132
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: UROD
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_484bce8e_d722_4f6f_9842_154910d68c4b
initial concentration: NaN
is: O00767
boundary condition: true
has only substance units: false
is encoded by: hsa:6319
initial amount: NaN
name: SCD
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_8550e0f0_099b_40ef_b277_62d46675bb7b
constant: false
boundary condition: true
initial concentration: NaN
name: PRDX2
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7001

metaM hepcoa m
has only substance units: false
type: Species
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
initial amount: NaN
name: heptanoylcoa
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB12969

metaR SBT Dtde
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110028#
name: D-sorbitol transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaR SEBACACT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR PROD2
kinetic law: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.5.99.8
name: Proline dehydrogenase
product: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
reversible: false
is: SBO:0000176
is described by: ECO:0000254

metaM thcholstoic c
is: CHEBI:18402
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB03873
type: Species
is: SBO:0000247

metaR FAOXC184x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaR DIGALSIDEtl
type: Reaction
name: digalside hs intracellular transport
reversible: true
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#

metaR FAOXC143C123m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_c95601f1_3b1f_4932_95ff_200bd295113e
has only substance units: false
initial concentration: NaN
is: O43820
is encoded by: hsa:8372
type: Species
is: SBO:0000252
constant: false
name: HYAL3
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_967fa41e_ffbc_4bd9_9489_e4203f73ee66
is: SBO:0000252
is encoded by: hsa:AI697028
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: _AI697028_1_m
initial amount: NaN
type: Species

metaR RE0577C
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
name: RE0577
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110028#

metaM q10 e
name: ubiquinone-10
initial amount: NaN
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
boundary condition: false
is: HMDB01072
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:46245

http://identifiers.org/biomodels.db/MODEL1310110028#_1d347445_2ab2_4364_8185_e46d38c5dfda
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: NME7
is encoded by: hsa:29922
is: Q9Y5B8
type: Species
is: SBO:0000252

metaM his L c
is: HMDB00177
name: L-histidine
initial amount: NaN
is: CHEBI:15971
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
constant: false

metaR RE0344C
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
name: RE0344
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM arachd c
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
type: Species
is: CHEBI:32395
initial amount: NaN
constant: false
name: arachidonate
initial concentration: 1.0
has only substance units: false
is: HMDB01043

http://identifiers.org/biomodels.db/MODEL1310110028#_1ddb98c7_e75d_43bd_8090_1b923131ba96
name: B4GALT2
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8704
initial amount: NaN
is: SBO:0000252

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaR r0836
type: Reaction
modifier: MODEL1310110028#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
reactant: MODEL1310110028#

metaM ptth m
is: CHEBI:16753
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB03426
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
name: pantetheine
constant: false
boundary condition: false
initial concentration: 1.0

metaM decdicoa c
type: Species
initial concentration: 1.0
name: decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01168
has only substance units: false

metaR TETPENT3t
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
name: fatty acid transport via diffusion
fast: false

metaM lgnccoa c
is: SBO:0000247
initial concentration: 1.0
is: HMDB06526
boundary condition: false
name: lignocericyl coenzyme A
constant: false
has only substance units: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
initial amount: NaN
type: Species

metaM hdcecrn c
initial concentration: 1.0
type: Species
has only substance units: false
name: Hexadecenoyl carnitine
boundary condition: false
constant: false
is: HMDB00222
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
initial amount: NaN
is: SBO:0000247

metaM tmndnccoa x
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06514
name: timnodonyl coenzyme A

metaM HC00319 m
type: Species
name: Malonate
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
constant: false
is: CHEBI:30794
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_a6c866c7_6de7_42f9_96df_f764f1db85f7
has part: Q9HCC0
initial amount: NaN
name: MCCC1:MCCC2
boundary condition: true
has part: Q96RQ3
initial concentration: NaN
is: SBO:0000297
has only substance units: false
is encoded by: hsa:56922
constant: false
is encoded by: hsa:64087
type: Species

metaM CE4872 c
boundary condition: false
initial concentration: 1.0
is: HMDB00127
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15748
type: Species

metaR PYAM5POr
is described by: ECO:0000269
modifier: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
is: SBO:0000176
name: pyridoxamine 5'-phosphate oxidase

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR COAtn
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110028#
is described by: ECO:0000000
name: coenzyme A transport, nuclear
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
fast: false

metaM xyl D c
is: CHEBI:15936
is: SBO:0000247
type: Species
constant: false
name: aldehydo-D-xylose
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1

metaM dopa e
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
is: CHEBI:59905
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00073
has only substance units: false
boundary condition: false
initial amount: NaN
name: dopaminium(1+)

http://identifiers.org/biomodels.db/MODEL1310110028#_ff010b15_a856_4272_a897_b96eedce9c0b
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10005
is: O14734
type: Species
constant: false
has only substance units: false
boundary condition: true
name: ACOT8

metaM Rtotal2 c
boundary condition: false
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB01564
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57876
type: Species
name: R total 2 position

metaM his L e
is: CHEBI:15971
is: HMDB00177
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
boundary condition: false
name: L-histidine
initial concentration: 1.0

metaR GGH 7THFe
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
product: MODEL1310110028#
modifier: MODEL1310110028#
name: Gamma-glutamyl hydrolase (7THF), extracellular
type: Reaction

metaR DECDPtm
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:ubiquinone precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#

metaR r0835
type: Reaction
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110028#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110028#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_a6f907ab_dae6_4d9d_b8d2_418d2480409c
is: SBO:0000252
name: GUCY1A2
initial amount: NaN
is encoded by: hsa:2977
has only substance units: false
type: Species
boundary condition: true
is: P33402
initial concentration: NaN
constant: false

metaM HC01842 c
is: CHEBI:31997
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: SBO:0000247
type: Species
name: Phosphodimethylethanolamine
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false

metaM h2o2 e
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03125
type: Species
name: hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
is: SBO:0000247

metaM 6thf e
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/169691
is: SBO:0000247
name: hexaglutamyl folate (THF)
has only substance units: false
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
initial amount: NaN
constant: false
initial concentration: 1.0

metaR COAtm
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reversible: true
product: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
name: CoA transporter
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110028#

metaM 3ohdcoa m
is: HMDB06402
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
is: CHEBI:57349
name: 3-oxopalmitoyl-CoA(4-)
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaR r0570
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.3.3.2
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM arachd e
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395
name: arachidonate
is: SBO:0000247
initial concentration: 1.0
is: HMDB01043

metaR S6T15g
is described by: ECO:0000000
type: Reaction
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110028#_50acd22d_44d2_4677_8fc3_296b91cfa7d2
has only substance units: false
name: _H77542_1_c
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:H77542
boundary condition: true
constant: false
is: SBO:0000252

metaR FAOXC184C164x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaM lanost r
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: lanosterol
is: CHEBI:16521
is: HMDB01251
is: SBO:0000247
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
initial concentration: 1.0
has only substance units: false

metaM h2o2 c
name: Hydrogen peroxide
has only substance units: false
is: SBO:0000247
is: CHEBI:16240
initial amount: NaN
constant: false
is: C00027
is: HMDB03125
initial concentration: 1.0
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_aafe1aeb_16f5_45e2_9bc5_d95962e0ec49
type: Species
is encoded by: hsa:10678
has only substance units: false
name: B3GNT2
is: Q9NY97
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN

metaR NTD9e
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:16325434 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000254
kinetic law: MODEL1310110028#
type: Reaction
name: 5'-nucleotidase (GMP), extracellular
modifier: MODEL1310110028#

metaM decdp m
has only substance units: false
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
name: all trans Decaprenyl diphosphate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB06288
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_0dd64ea3_e85e_48c2_b9f0_5c0edd9d9636
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
name: ACSL6
is encoded by: hsa:23305
initial concentration: NaN
is: B2RB13
has only substance units: false
boundary condition: true

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR COAtl
reactant: MODEL1310110028#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110028#
name: CoA transport in lysosome via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#

metaM gam6p c
boundary condition: false
is: HMDB01254
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
name: D-Glucosamine 6-phosphate
is: SBO:0000247
is: CHEBI:12962
initial amount: NaN
constant: false

metaR DECCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaM Rtotal2 e
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
is: C00255
initial concentration: 1.0
is: HMDB00244
type: Species
is: CHEBI:3554
name: R total 2 position
initial amount: NaN

metaM xyl D e
is: SBO:0000247
is: CHEBI:15936
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: aldehydo-D-xylose
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false

metaR C160CRNt
name: C160 transport into the mitochondria
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
product: MODEL1310110028#
fast: false
type: Reaction
modifier: MODEL1310110028#
reversible: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_923e6425_8eb3_4235_9235_244fa2ad9457
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: O00217
name: NDUFS8
is encoded by: hsa:4728
is: SBO:0000252

metaM lac D c
is: CHEBI:16004
is: HMDB01311
type: Species
has only substance units: false
is: SBO:0000247
name: (R)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR DNDPt17m
modifier: MODEL1310110028#
reversible: false
name: dUDP transport via dCDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000185

metaM HC01434 c
name: oxalatosuccinate(3-)
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: CHEBI:58931
boundary condition: false
is: SBO:0000247

metaR GCALDD
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
reactant: MODEL1310110028#
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction

metaM 3ttetddcoacrn e
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
is: HMDB02014
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C21H37NO5 CHARGE: 0

metaR H2CO3D
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
type: Reaction
kinetic law: MODEL1310110028#
fast: false
name: carboxylic acid dissociation
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.1

metaM ei11ecoa x
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
type: Species
name: 11-eicosenoylcoa
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ffda3f1c_1099_4f34_bd48_c175aa7b9003
type: Species
boundary condition: true
is encoded by: hsa:6472
name: SHMT2
is: B4DJQ3
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM gdpfuc c
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false
type: Species
constant: false
name: GDP-L-fucose(2-)
initial amount: NaN
is: HMDB01095
initial concentration: 1.0
is: CHEBI:57984
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_e63f9593_2138_47da_b519_b7daba27dda4
initial concentration: NaN
initial amount: NaN
type: Species
is: P49914
is encoded by: hsa:10588
constant: false
has only substance units: false
is: SBO:0000252
name: MTHFS
boundary condition: true

metaR FAOXC102C81m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_6b96c0cc_9852_42b3_9088_d236a8c3f713
has only substance units: false
is: SBO:0000252
name: ATP1A1
type: Species
is: B7Z3U6
is encoded by: hsa:476
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_9077e8e9_621f_449d_a010_24f0346d15e4
is encoded by: hsa:5293
initial amount: NaN
is: A7E2E0
has only substance units: false
type: Species
name: PIK3CD
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaR ACGALtly
fast: false
is: SBO:0000185
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
name: N-acetyl-galactosamine lysosomal efflux

metaM nadh m
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00004
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN

metaR r2080
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM ethamp c
is: CHEBI:58190
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
constant: false
is: SBO:0000247
is: HMDB00224
initial amount: NaN
name: ethamp[c]
has only substance units: false

metaR FAOXC184m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR FAOXC143C123x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaM 5pmev x
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
is: SBO:0000247
has only substance units: false
is: HMDB01343
boundary condition: false
name: (R)-5-phosphonatomevalonate(3-)
initial amount: NaN
constant: false
is: CHEBI:58146
type: Species
initial concentration: 1.0

metaR GLUDxm
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000269
modifier: MODEL1310110028#
name: glutamate dehydrogenase (NAD) (mitochondrial)
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:

metaM thyox L e
constant: false
initial amount: NaN
is: HMDB00248
initial concentration: 1.0
has only substance units: false
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: CHEBI:18332
type: Species
is: SBO:0000247
boundary condition: false

metaR r0422
product: MODEL1310110028#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
modifier: MODEL1310110028#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000176

metaM mn l
is: SBO:0000247
constant: false
is: HMDB06535
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
type: Species
has only substance units: false
name: beta-1,4-mannose-N-acetylglucosamine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_496b7bfd_93a7_48fe_b78b_126fe87c02cd
has only substance units: false
name: GSR
initial amount: NaN
initial concentration: NaN
is: P00390
constant: false
type: Species
boundary condition: true
is encoded by: hsa:2936
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_4e0a7b1f_a6f6_4a4b_b3c7_734373102ba0
is: SBO:0000252
is encoded by: hsa:3073
name: HEXA
is: P06865
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaR r0839
name: Postulated transport reaction
reactant: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.70
fast: false
is: SBO:0000185
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
type: Reaction
kinetic law: MODEL1310110028#

metaM HC02214 c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:28852
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_53c23b52_b477_4eac_89cd_49dc6f95ce24
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9UJS0
name: SLC25A13
type: Species
is: SBO:0000252
is encoded by: hsa:10165

metaM xol7aone c
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
is: CHEBI:17899
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

metaR NDPK9n
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear

metaM lac D e
initial concentration: 1.0
is: HMDB01311
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
constant: false
name: (R)-lactate
is: CHEBI:16004
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM 5eipencoa m
is: SBO:0000247
boundary condition: false
name: 5,8,11,14,17-eicosapentenoylcoa
initial concentration: 1.0
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4

metaR BPNT
name: 3',5'-bisphosphate nucleotidase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.3.7
type: Reaction

metaR r2081
fast: false
is: SBO:0000185
kinetic law: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110028#

metaR UAGALDP
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
fast: false
name: UDP-N-acetylgalactosamine diphosphorylase

metaM o2 e
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: O2
is: CHEBI:15379
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
has only substance units: false
is: C00007
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_1e725076_9983_4dad_bf90_fb7e709a1e7b
name: ARSA
is encoded by: hsa:410
constant: false
initial concentration: NaN
boundary condition: true
is: P15289
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaM oxa m
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
name: oxalate(2-)
is: HMDB02329
initial concentration: 1.0
has only substance units: false
is: CHEBI:30623

metaM thyox L c
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:18332
name: L-thyroxine
boundary condition: false
is: SBO:0000247
is: HMDB00248
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_5708a4a3_f019_4578_ada4_83092511ff59
type: Species
is encoded by: hsa:2348
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: FOLR1
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_7c6b1ea8_a9f5_43de_b7f3_740db0e5a32b
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: AK4
type: Species
is encoded by: hsa:205
constant: false
is: P27144
initial amount: NaN

metaR r0838
kinetic law: MODEL1310110028#
fast: false
type: Reaction
modifier: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
reactant: MODEL1310110028#
is described by: ECO:0000000
name: Free diffusion
is version of: http://identifiers.org/ec-code/3.1.2.4
product: MODEL1310110028#
reversible: true

metaR RE1516M
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
type: Reaction
name: RE1516
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
product: MODEL1310110028#

metaR GAMt1r
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000269
fast: false
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
reversible: true
name: glucosamine transport (uniport)

http://identifiers.org/biomodels.db/MODEL1310110028#_7bd3c871_fe81_46aa_a611_7b3bace11ebc
boundary condition: true
type: Species
is: Q9NST1
name: PNPLA3
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:80339
is: SBO:0000252

metaR r2083
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
product: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_33cd7e9b_d45f_47eb_8063_1a362dcd3b6f
name: CROT
is: SBO:0000252
type: Species
initial concentration: NaN
is: E7EQF2
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:54677
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_a8da4995_a77f_4f6c_ab77_6511c25f0b2f
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: _T83654_1_c
is encoded by: hsa:T83654
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_d161da87_ab01_483c_973c_b41c7cdec12b
initial concentration: NaN
is encoded by: hsa:50700
constant: false
name: RDH8
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is: Q9NYR8

metaR r2082
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110028#
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#

metaM ksi pre36 g
constant: false
name: keratan sulfate I biosynthesis, precursor 36
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
is: CHEBI:28067

metaM acgal1p c
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
type: Species
name: N-Acetyl-D-galactosamine 1-phosphate
initial concentration: 1.0
is: CHEBI:55404
boundary condition: false
constant: false
initial amount: NaN
is: HMDB06480
has only substance units: false

metaR GGH 10FTHF5GLUe
reactant: MODEL1310110028#
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
modifier: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_514910df_96e4_47f3_aa1a_74f9ed895553
initial concentration: NaN
constant: false
is: Q13454
is encoded by: hsa:7991
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: TUSC3

metaR r0424
reversible: true
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_29ac8224_4c04_4133_a2b1_2e96085559d7
initial concentration: NaN
has only substance units: false
name: PLCD3
is: Q8N3E9
type: Species
is: SBO:0000252
is encoded by: hsa:113026
constant: false
boundary condition: true
initial amount: NaN

metaM HC01407 m
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
is: CHEBI:28276
type: Species
is: SBO:0000247
boundary condition: false
name: (S)-Hydroxyhexanoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_6efd8e32_00d2_4605_8b3a_9dc7858a7670
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:8776
is: Q13613
name: MTMR1
initial amount: NaN

metaR C101CRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR r2084
is: SBO:0000185
fast: false
modifier: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
type: Reaction

metaM mi134p c
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
type: Species
boundary condition: false
is: HMDB01143
is: CHEBI:58414
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
initial amount: NaN

metaM HC01399 m
is: CHEBI:27466
is: SBO:0000247
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
name: (S)-3-Hydroxytetradecanoyl-CoA
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_5995b318_9d1d_45e2_a003_1bad4d4e96a5
initial amount: NaN
is: P28329
is: SBO:0000252
name: CHAT
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1103
type: Species
constant: false

metaR ELAIDt
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
name: fatty acid transport via diffusion

metaR PUNP7
type: Reaction
product: MODEL1310110028#
name: purine-nucleoside phosphorylase (Xanthosine)
modifier: MODEL1310110028#
is described by: ECO:0000269
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false

metaR r0423
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110028#

metaR G14Tg
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000269
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110028#

metaR ILETAm
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
fast: false
name: isoleucine transaminase, mitochondrial
reversible: true
is: SBO:0000176

metaR FACOAL2251
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: fatty-acid--CoA ligase
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110028#
reversible: true

metaR 34DHXMANDACOX NADP
kinetic law: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110028#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
is described by: ECO:0000269
reactant: MODEL1310110028#
product: MODEL1310110028#

metaR MTHFD2m
is described by: ECO:0000254
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
fast: false

metaR DASPO1p
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110028#
product: MODEL1310110028#
name: D-aspartate oxidase, peroxisomal
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.4.3.1
reversible: false
notes: GENE_ASSOCIATION: (8528.2) or (8528.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 1.4.3.1 Confidence Level: 4 AUTHORS: PMID:12209855,PMID:9820813 NOTES:MM

metaM g1p e
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial concentration: 1.0
has only substance units: false
name: alpha-D-glucose 1-phosphate(2-)
is: HMDB01586
is: CHEBI:58601
constant: false

metaM HC01223 m
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial amount: NaN
boundary condition: false
has only substance units: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
type: Species
is: SBO:0000247
constant: false
is: CHEBI:57340

metaR r2086
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_eac21627_91a6_4ecb_b432_f6736dc90221
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q6ZMR3
type: Species
initial amount: NaN
name: LDHAL6A
is encoded by: hsa:160287

metaM ksi deg16 l
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
is: HMDB01354
is: CHEBI:57455
initial amount: NaN
name: keratan sulfate I, degradation product 16
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM o2 r
is: C00007
initial concentration: 1.0
type: Species
is: CHEBI:15379
is: HMDB01377
name: O2
has only substance units: false
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
initial amount: NaN
constant: false

metaM nadh r
initial amount: NaN
boundary condition: false
is: HMDB01487
is: CHEBI:57945
constant: false
type: Species
name: NADH(2-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004

metaM sgalside hs g
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: sulfatide galactocerebroside
is: HMDB00061
is: CHEBI:58343
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1

metaM mlthf c
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
constant: false
is: C00143
is: CHEBI:15636
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01533
name: 5,10-Methylenetetrahydrofolate
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR r0426
modifier: MODEL1310110028#
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.34
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_964b6afe_d3e0_4048_9d45_62387d1d8b49
is encoded by: hsa:6520
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P08195
type: Species
constant: false
name: SLC3A2

http://identifiers.org/biomodels.db/MODEL1310110028#_54dc3b6e_fe71_4b32_8ba1_b37df5ff1f9e
name: PANK1
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:53354
type: Species

metaR FAOXC1811602m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
type: Reaction
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110028#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is described by: ECO:0000000

metaR S6TASE3ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
fast: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110028#

metaR r0119
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
product: MODEL1310110028#
modifier: MODEL1310110028#

metaR ASNNm
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
reversible: false
modifier: MODEL1310110028#
fast: false
name: L-asparaginase (mitochondrial)
is described by: ECO:0000254
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.1
is: SBO:0000176
product: MODEL1310110028#
reactant: MODEL1310110028#

metaR THCHOLSTOICtm
type: Reaction
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
is: SBO:0000185
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false

metaR r2085
fast: false
is: SBO:0000185
modifier: MODEL1310110028#
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110028#

metaM HC01415 m
initial concentration: 1.0
type: Species
is: CHEBI:27537
name: (2E)-Octenoyl-CoA
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
initial amount: NaN

metaR r1671
is described by: ECO:0000000
modifier: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
fast: false
product: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110028#

metaM xyl D l
constant: false
is: CHEBI:15936
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
name: aldehydo-D-xylose

metaM dutp n
name: dUTP
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01191
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_e1ba55db_172c_47f4_8cfe_f9660008e1b1
initial amount: NaN
has only substance units: false
name: RDH13
type: Species
is encoded by: hsa:112724
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: B3KVA3

http://identifiers.org/biomodels.db/MODEL1310110028#_441058b5_0e05_483f_b65b_438aab4a2de6
name: MVD
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4597
is: P53602
type: Species

metaM 4hglusa m
is: HMDB06556
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: L-4-hydroxyglutamic semialdehyde
constant: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: SBO:0000247
has only substance units: false
is: CHEBI:27809

metaM arachcoa m
constant: false
is: HMDB04258
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:15527
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR S6TASE1ly
type: Reaction
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110028#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110028#_d23afc66_91d5_4ff5_a703_c07e5e14d04c
name: B4GALT1:LALBA
initial concentration: NaN
has part: P00709
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:3906
is: SBO:0000297

metaM g1p c
is: C00103
initial amount: NaN
name: D-Glucose 1-phosphate
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
has only substance units: false
is: SBO:0000247
is: CHEBI:58601
is: HMDB01586

metaR r2088
product: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_58220c70_86fd_419a_8e5d_dc7b5e7e1ab6
is encoded by: hsa:25902
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: MTHFD1L
is: B2RD24

http://identifiers.org/biomodels.db/MODEL1310110028#_3db23306_c84d_415b_80bc_7ad5b7adc930
boundary condition: true
initial concentration: NaN
name: ACSS2
has only substance units: false
is: SBO:0000252
is: Q5QPH3
is encoded by: hsa:55902
constant: false
type: Species
initial amount: NaN

metaR r0829
is version of: http://identifiers.org/ec-code/4.1.1.37
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110028#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_57e6ecfd_5cca_4b47_9f88_a7a5f2afe89f
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4717
is: SBO:0000252
initial amount: NaN
name: NDUFC1
is: O43677

metaM CE4872 m
type: Species
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
has only substance units: false
is: HMDB00127
is: SBO:0000247
is: CHEBI:15748
boundary condition: false

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_bde9415b_2cfe_4b01_b2d2_b3afef875013
type: Species
is encoded by: hsa:5464
name: PPA1
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q15181

http://identifiers.org/biomodels.db/MODEL1310110028#_e48bdd09_bb42_4217_92c4_255f2bb07e2d
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10246
name: SLC17A2
type: Species
constant: false
is: O00624

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaR FACOAL2252
modifier: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
name: fatty-acid--CoA ligase
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
reactant: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_b0151e0a_3343_4e53_b4e7_ab96cb9fbcd5
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P31040
name: SDHA
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:6389

metaR SPMDOX
reversible: false
name: Spermidine:(acceptor) oxidoreductase
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: beta-Alanine metabolism EC Number: 1.5.99.6 Confidence Level: 2 AUTHORS: PMID:10657958 NOTES:SAB
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false

metaR FAOXC185m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR r2087
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110028#
reversible: true
is: SBO:0000185
reactant: MODEL1310110028#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_6891bd75_6c93_4058_9b2d_697f71bf2d60
is: SBO:0000252
name: _AI934540_1_c
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:AI934540
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_9bd3089f_3955_4b49_88a4_e395e8ceb09f
boundary condition: true
name: NME4
is: O00746
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4833
has only substance units: false

metaR ARACHt
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110028#
name: fatty acid transport via diffusion
reversible: true

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_962a5ff1_0221_4f57_9dd8_acaec48d259b
constant: false
is: Q6NVY1
initial concentration: NaN
name: HIBCH
has only substance units: false
is encoded by: hsa:26275
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM hexc e
constant: false
is: CHEBI:31013
has only substance units: false
boundary condition: false
name: cerotate
initial amount: NaN
is: SBO:0000247
is: HMDB02356
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
initial concentration: 1.0
type: Species

metaR 34DHXMANDACOX
product: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB

metaM o2 m
is: C00007
is: CHEBI:15379
type: Species
is: HMDB01377
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_2e46f17d_5af1_4b6e_8da6_6988dffc1398
type: Species
constant: false
boundary condition: true
is encoded by: hsa:6342
initial amount: NaN
name: SCP2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: C9JC79

http://identifiers.org/biomodels.db/MODEL1310110028#_cea195ec_7a9c_4e06_8134_b3c5df6ace72
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:AI697028
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _AI697028_1_e

metaM ksi pre27 g
initial amount: NaN
is: C00130
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 27
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_11b59631_6ce8_4272_9ba7_aaa86c2224e0
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: P61457
is encoded by: hsa:5092
boundary condition: true
constant: false
name: PCBD1
initial amount: NaN

metaM o2 n
initial concentration: 1.0
name: dioxygen
is: CHEBI:15379
initial amount: NaN
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
is: SBO:0000247
is: HMDB01377
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_5b51f865_43f5_44d2_87e6_ba474f65d134
constant: false
initial concentration: NaN
name: ATP1A4
initial amount: NaN
is: Q13733
is encoded by: hsa:480
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_a3ee76e9_5b79_4209_a81a_ee379a7443f5
is: P49902
initial concentration: NaN
has only substance units: false
name: NT5C2
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:22978

metaR EX c4crn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_e9f14dc9_49c2_4c18_89c4_5fdec99193e5
initial concentration: NaN
is: Q8N9L9
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:122970
initial amount: NaN
is: SBO:0000252
name: ACOT4
type: Species

metaR GLCAASE9ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: beta-glucuronidase, lysosomal
reversible: false
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110028#_f0beca9f_db38_40ab_8a08_64c2f931e656
name: CYP8B1
type: Species
is: Q9UNU6
is encoded by: hsa:1582
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR RNDR4
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: ribonucleoside-diphosphate reductase (UDP)
type: Reaction
is described by: ECO:0000254
reversible: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_d0dd3319_4098_4d63_9c5e_e350f0c697c7
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:195814
initial amount: NaN
has only substance units: false
boundary condition: true
name: SDR16C5
constant: false
is: B3KT84
type: Species

metaM dutp m
is: SBO:0000247
initial amount: NaN
name: dUTP
initial concentration: 1.0
is: CHEBI:17625
boundary condition: false
is: HMDB01191
constant: false
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species

metaM sgalside hs l
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00904
is: CHEBI:16349
constant: false
name: sulfatide galactocerebroside

http://identifiers.org/biomodels.db/MODEL1310110028#_5f445264_f21c_49dc_8ad1_8b278e7a1a92
name: ATP5A1
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:498
is: P25705
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM 2hexdtetcoa x
is: HMDB02288
has only substance units: false
boundary condition: false
constant: false
name: 2,7,10,13-hexadecatetraenoylcoa
type: Species
initial amount: NaN
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247

metaR r0002
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reactant: MODEL1310110028#
name: Active transport

metaR SPMTDe
reactant: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: true
name: SPMTDe
fast: false
is described by: ECO:0000134
product: MODEL1310110028#
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_3b9aecaa_3ebb_491e_b666_81dd21f2b773
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AA081045
name: _AA081045_1_c
initial amount: NaN
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_1e2a49dc_a9eb_4be6_9028_7e4846000acc
is: SBO:0000252
constant: false
is: O15382
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: BCAT2
is encoded by: hsa:587
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_58c55070_282d_4f99_a65e_50f068ecbfa3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O60909
is encoded by: hsa:8704
constant: false
name: B4GALT2
type: Species
initial amount: NaN
has only substance units: false

metaM bhb c
is: SBO:0000247
is: HMDB00011
constant: false
boundary condition: false
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
has only substance units: false
initial amount: NaN

metaR MECOAS1m
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
type: Reaction
reactant: MODEL1310110028#
name: mesaconate--CoA ligase (GDP-forming)
product: MODEL1310110028#
is described by: ECO:0000304
modifier: MODEL1310110028#
reversible: true

metaR r2089
is described by: ECO:0000000
modifier: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
reversible: true
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_d44b8abb_01f3_4d09_be9c_f754bee56c9d
is: SBO:0000252
initial amount: NaN
name: RDH11
is encoded by: hsa:51109
is: B4DDW0
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_5fadaad1_aeeb_4fe7_afd6_6e09d82bedba
is encoded by: hsa:2678
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P19440
constant: false
is: SBO:0000252
name: GGT1
type: Species

metaR DM mem2emgacpail prot hs r
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM mem2emgacpail prot hs(r)
type: Reaction

metaR RNDR3
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
name: ribonucleoside-diphosphate reductase (CDP)
reactant: MODEL1310110028#
type: Reaction

metaM hexc c
is: SBO:0000247
is: CHEBI:31013
name: cerotate
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB02356
initial concentration: 1.0
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
constant: false

metaR C30CPT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_7fca8847_9ac7_49b3_b971_008a74d7f5c3
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: SLC2A9
is: Q9NRM0
is encoded by: hsa:56606
has only substance units: false
initial amount: NaN

metaM ksi deg29 l
name: keratan sulfate I, degradation product 29
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
initial concentration: 1.0
boundary condition: false
is: CHEBI:12936
initial amount: NaN
type: Species
is: HMDB00143
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_0f498673_0666_4df5_afc7_b5f3763651c5
is: SBO:0000252
is: Q92947
type: Species
name: GCDH
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2639
constant: false
boundary condition: true

metaR LPCOXp
is: SBO:0000176
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
fast: false
product: MODEL1310110028#
name: L-pipecolate oxidase, peroxisomal
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.5.3.1
kinetic law: MODEL1310110028#
is described by: ECO:0000269

metaM nadh x
is: HMDB01487
is: SBO:0000247
boundary condition: false
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: C00004
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_1c28c733_16a3_40b8_88d5_aef8edc48e28
name: ALG8
initial concentration: NaN
is encoded by: hsa:79053
type: Species
is: Q9BVK2
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

metaR r1670
reversible: true
type: Reaction
modifier: MODEL1310110028#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110028#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
is: SBO:0000185

metaR ALADGLYexR
fast: false
name: D-alanine/glycine reversible exchange
reactant: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true

metaR RNDR2
name: ribonucleoside-diphosphate reductase (GDP)
is: SBO:0000176
modifier: MODEL1310110028#
fast: false
reversible: false
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_d7bf81a2_bc5e_4b14_910d_fd0e5ffa5b52
has only substance units: false
is encoded by: hsa:23517
constant: false
is: Q3MHC9
name: SKIV2L2
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species

metaM glc D c
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
has only substance units: false
name: D-glucose
is: HMDB00122
initial amount: NaN
is: CHEBI:4167
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_6a756040_e456_4ada_a0e9_512492298b61
is encoded by: hsa:5315
has only substance units: false
boundary condition: true
initial amount: NaN
name: PKM2
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaM hdd2coa x
type: Species
has only substance units: false
name: (E)-hexadec-2-enoyl-CoA(4-)
is: CHEBI:61526
constant: false
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial concentration: 1.0
is: HMDB03945
initial amount: NaN
is: SBO:0000247

metaR GLCURter
reversible: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: glucuronate endoplasmic reticular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110028#
fast: false

metaM 3docopencoa x
has only substance units: false
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
name: 3,7,10,13,16-docosapentenoylcoa

metaR MANt4
is described by: ECO:0000269
modifier: MODEL1310110028#
type: Reaction
reversible: true
reactant: MODEL1310110028#
name: D-mannose transport via sodium cotransport
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR AG13T12g
kinetic law: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_2decb5f2_05d0_463a_87ed_1bcc58ebdeaa
has only substance units: false
initial concentration: NaN
type: Species
is: O00219
constant: false
is encoded by: hsa:3038
name: HAS3
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR ALR3
name: aldose reductase (acetol)
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
is: SBO:0000176
reversible: false
product: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_cd0fec50_3bbf_47a5_9bbf_fdf13b605cfe
initial amount: NaN
initial concentration: NaN
name: PLA2G12A
constant: false
boundary condition: true
is encoded by: hsa:81579
is: Q542Y6
has only substance units: false
is: SBO:0000252
type: Species

metaM bhb e
boundary condition: false
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
type: Species
is: CHEBI:10983
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
has only substance units: false
constant: false

metaR CMPSAS
reactant: MODEL1310110028#
fast: false
name: CMP sialic acid synthase
is: SBO:0000176
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.7.43

metaR EX c4dc
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

metaM andrstrn r
is: CHEBI:16032
has only substance units: false
name: androsterone
is: HMDB00031
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial concentration: 1.0
is: SBO:0000247

metaR S2TASE3ly
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: false
name: iduronate-2-sulfatase, lysosomal

metaR ALR2
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
fast: false
name: aldose reductase (methylglyoxal)
is version of: http://identifiers.org/ec-code/1.1.1.21

metaR M4BTAer
reversible: false
name: M4B transamidase, endoplasmic reticulum
product: MODEL1310110028#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (10026.1) and (128869.1) and (8733.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15208306,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
is described by: ECO:0000000
kinetic law: MODEL1310110028#

metaR PHYTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110028#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid transport via diffusion
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaM arachcoa c
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
has only substance units: false
name: arachidyl coenzyme A
initial concentration: 1.0
boundary condition: false
is: CHEBI:15527
is: SBO:0000247
is: HMDB04258
initial amount: NaN
type: Species
constant: false

metaM 13dpg c
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
constant: false
is: HMDB01270
is: C00236
is: CHEBI:57604
is: http://identifiers.org/pubchem.compound/3535
name: 3-Phospho-D-glyceroyl phosphate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_e3eb42a5_0402_415e_8a66_28e2d17d95ca
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P23677
type: Species
boundary condition: true
constant: false
name: ITPKA
is: SBO:0000252
is encoded by: hsa:3706

metaR PTDCACRNt
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110028#
fast: false
type: Reaction
name: pentadecanoate transport into the mitochondria
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
reactant: MODEL1310110028#
product: MODEL1310110028#

metaR MANtly
is: SBO:0000185
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
is described by: ECO:0000000
name: mannose efflux from lysosome
reversible: false
type: Reaction

metaR GLCNACASE2ly
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50
modifier: MODEL1310110028#
fast: false
reversible: false

metaR RE3381E
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110028#
name: RE3381
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.31
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false

metaM glc D e
initial concentration: 1.0
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00122
initial amount: NaN
is: CHEBI:4167
has only substance units: false
constant: false

metaM clpnd c
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB06528
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial amount: NaN
name: clupanodonic acid
is: CHEBI:53488
has only substance units: false
initial concentration: 1.0

metaM c16dc c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00712
type: Species
notes: FORMULA: C23H42NO6 CHARGE: -1
constant: false
name: Hexadecanedioic acid mono-L-carnitine ester

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR AIRCr
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
product: MODEL1310110028#
name: phosphoribosylaminoimidazole carboxylase

metaM tethex3 c
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02007
is: SBO:0000247
initial concentration: 1.0
name: tetracosahexaenoic acid, n-3
type: Species
has only substance units: false

metaM mi13p c
name: 1D-myo-Inositol 1,3-bisphosphate
has only substance units: false
boundary condition: false
is: CHEBI:18225
is: HMDB06234
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_21bfad64_a987_4930_acf6_b5d74ea62d2f
constant: false
is encoded by: hsa:5287
initial concentration: NaN
name: PIK3C2B
type: Species
is: O00750
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR SPHS1Ptr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
name: sphingosine-1-phosphate transport
kinetic law: MODEL1310110028#

metaM HC02210 c
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:34939
name: prostaglandin-d3
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN

metaR S6T7g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176

metaM subeac c
notes: FORMULA: C8H12O4 CHARGE: -2
type: Species
is: HMDB00893
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
name: suberic acid
initial amount: NaN

metaR FAOXC2442246x
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Beta oxidation of long chain fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR THMP
product: MODEL1310110028#
name: thiamin phosphatase
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_32715e98_176c_4bd5_bd8a_2c66c8ad2c2e
name: _M68895_1_c
is encoded by: hsa:M68895
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaM HC10852 r
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: palmitoleyl-CoA(4-)
type: Species
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
is: CHEBI:61540
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_1d36393d_f95e_4709_a667_d2fe858840d4
is: SBO:0000252
boundary condition: true
constant: false
is: F5H2Y9
has only substance units: false
is encoded by: hsa:8854
name: ALDH1A2
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_8c075b6a_26c2_49db_ab43_45248ada9664
initial amount: NaN
has only substance units: false
is encoded by: hsa:5277
constant: false
type: Species
name: PIGA
is: SBO:0000252
initial concentration: NaN
is: P37287
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_c0dc6a29_8a46_42aa_ba8c_43c1669e2b54
has only substance units: false
is encoded by: hsa:8703
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is: A8K5Z0
name: B4GALT3

http://identifiers.org/biomodels.db/MODEL1310110028#_7d068302_9aed_447b_bb4e_2095f8de2918
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: AGA
is: P20933
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:175

metaM 34dhpac c
type: Species
is: SBO:0000247
name: 3,4-Dihydroxyphenylacetaldehyde
is: CHEBI:27978
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
boundary condition: false
initial amount: NaN
is: HMDB03791
has only substance units: false
initial concentration: 1.0
constant: false

metaR AICARte
is described by: ECO:0000134
fast: false
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_94d52cd3_5d0e_453d_80b9_77e12ce8f2ce
constant: false
is encoded by: hsa:10587
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: TXNRD2

metaR r0113
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 0 AUTHORS: PMID:10431835,PMID:15748884,PMID:3740419,PMID:4337336,PMID:5063602,PMID:5417402,PMID:9305887,PMID:9305888 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction
is: SBO:0000176
name: UDP-N-acetyl-D-glucosamine 2-epimerase Aminosugars metabolism EC:5.1.3.14
reversible: false
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#

metaM phaccoa c
name: phenylacetyl-CoA(4-)
is: HMDB06503
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
is: CHEBI:57390

metaR O2Stm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110028#
is described by: ECO:0000000
fast: false
name: superoxide anion transport via diffusion (mitochondria)
type: Reaction
product: MODEL1310110028#
is: SBO:0000185
reversible: true
reactant: MODEL1310110028#

metaR FADH2tx
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110028#
name: FADH2 transporter, peroxisomal
fast: false
is described by: ECO:0000000

metaM c16dc e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H42NO6 CHARGE: -1
is: HMDB00712
is: SBO:0000247
name: Hexadecanedioic acid mono-L-carnitine ester
boundary condition: false
constant: false
type: Species

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM glc D g
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
type: Species
initial amount: NaN
is: CHEBI:4167
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_71f439a5_5005_4002_b526_37286dd9ea8a
has only substance units: false
is encoded by: hsa:3417
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: O75874
name: IDH1
is: SBO:0000252

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_c0be7ef9_2080_4720_b347_447c4b21ce0f
name: SPHK2
initial concentration: NaN
is: Q9NRA0
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:56848

metaM HC02210 e
constant: false
type: Species
is: CHEBI:34939
is: SBO:0000247
boundary condition: false
name: prostaglandin-d3
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN

metaR O2Stn
is described by: ECO:0000000
name: superoxide anion transport via diffusion (nucleus)
type: Reaction
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_a8a74f02_3119_45ea_a9f1_edafa41291ea
is: P13686
is: SBO:0000252
boundary condition: true
name: ACP5
type: Species
is encoded by: hsa:54
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false

metaM thcholstoic m
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
is: CHEBI:18402
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_e1f4e211_6cb8_4056_bb97_09700f871809
boundary condition: true
is: P30838
type: Species
is: SBO:0000252
name: ALDH3A1
initial amount: NaN
constant: false
is encoded by: hsa:218
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_1db3cc14_8b25_4590_923e_94755e017fb6
is encoded by: hsa:10164
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: CHST4
type: Species
is: Q8NCG5
is: SBO:0000252

metaR DOLPMT U
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
fast: false
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.83
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_67a4e91a_be54_4bd1_b96f_9eaaf28f2165
type: Species
has only substance units: false
initial concentration: NaN
name: GLO1
initial amount: NaN
boundary condition: true
is: Q04760
constant: false
is: SBO:0000252
is encoded by: hsa:2739

metaR r0009
is version of: http://identifiers.org/ec-code/3.6.1.1
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
reversible: false
modifier: MODEL1310110028#
fast: false
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
product: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton

http://identifiers.org/biomodels.db/MODEL1310110028#_2cf14907_9595_45c0_917c_5b0e7bb45226
has only substance units: false
name: NOS3
type: Species
is: A0S0A7
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:4846
initial concentration: NaN

metaM tethex3 e
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
is: HMDB02007
name: tetracosahexaenoic acid, n-3
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_dfabd4b7_17d7_4baf_af8e_fc8c6485c08d
initial amount: NaN
is: Q9H845
type: Species
boundary condition: true
name: ACAD9
is encoded by: hsa:28976
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaM ptdcacrn m
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
initial concentration: 1.0
name: pendtadenoyl carnitine
constant: false
is: CHEBI:18303
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

metaR PTDCAt
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110028#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: fatty acid transport via diffusion

metaR RETNt
product: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
is: SBO:0000185
name: retinoic acid transport
fast: false
reversible: true
kinetic law: MODEL1310110028#
type: Reaction

metaR DSREDUCr
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book.
is version of: http://identifiers.org/ec-code/1.3.1.72
reversible: false
type: Reaction
is described by: ECO:0000134
product: MODEL1310110028#
name: Desmosterol reductase
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

metaM HC01408 m
initial amount: NaN
boundary condition: false
name: 3-Oxohexanoyl-CoA
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:27648
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_e2bea01b_09fe_4b4d_8b1b_57209eb2f252
is encoded by: hsa:BE966236
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: _BE966236_1_c
initial concentration: NaN

metaR DM pnto R
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for (R)-Pantothenate
type: Reaction

metaM lgnccoa x
initial amount: NaN
type: Species
is: HMDB06526
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: lignocericyl coenzyme A
has only substance units: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1

metaM HC02179 e
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:34306
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
has only substance units: false
initial concentration: 1.0
constant: false

metaR EX c101crn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_1deefcad_289e_40f4_8dbc_f3f45f740b05
initial concentration: NaN
initial amount: NaN
type: Species
name: _HG2846_HT2983_1_c
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983

metaR EHGLAT2m
is described by: ECO:0000304
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
reactant: MODEL1310110028#
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM q10 m
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
is: CHEBI:46245
is: HMDB01072
boundary condition: false
constant: false
name: ubiquinone-10
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_407ab248_389a_49ca_8ac9_675a150bfa2c
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5244
is: A4D1D5
constant: false
name: ABCB4
is: SBO:0000252

metaM o2 x
is: HMDB01377
boundary condition: false
is: C00007
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
is: CHEBI:15379
type: Species

metaR DNDPt38m
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: dUTP transport via dUDP antiport
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110028#
reversible: false
is: SBO:0000185
type: Reaction

metaM dolmanp L r
initial amount: NaN
is: CHEBI:15809
initial concentration: 1.0
name: Dolichyl phosphate D-mannose, human liver homolog
has only substance units: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
is: SBO:0000247
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_baa0220b_371f_419e_b6bb_e40b6db339ac
initial concentration: NaN
name: ATP2B3
initial amount: NaN
boundary condition: true
is encoded by: hsa:492
type: Species
is: Q16720
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_87aedc64_28fe_467f_bea0_750e64e868ab
has part: Q53G02
initial concentration: NaN
constant: false
has part: P39656
is encoded by: hsa:1650
has part: P04843
has only substance units: false
initial amount: NaN
is encoded by: hsa:1603
is encoded by: hsa:6185
has part: P04844
name: DAD1:DDOST:RPN1:RPN2
is encoded by: hsa:6184
type: Species
is: SBO:0000297
boundary condition: true

metaR TDCHOLAtx
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
product: MODEL1310110028#
is described by: ECO:0000000
fast: false
type: Reaction
name: bile acid intracellular transport
reactant: MODEL1310110028#

metaR FAOXC185C164m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_784d75d2_cd30_4fb2_823f_b9544ac2c1d3
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR GGT5r
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
is described by: ECO:0000134
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
reversible: true
fast: false
reactant: MODEL1310110028#
name: Gamma-glutamyltransferase 5
modifier: MODEL1310110028#
is: SBO:0000176

metaM HC02179 c
is: CHEBI:34306
initial amount: NaN
constant: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
type: Species
boundary condition: false
initial concentration: 1.0
name: 20-hydroxy-arachidonate
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_113d8dce_c424_4be7_89a3_ce858b87ef08
name: NPR2
is: P20594
initial amount: NaN
is encoded by: hsa:4882
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaR r1090
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110028#
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaR ASNt4
name: L-asparagine transport in via sodium symport
modifier: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
is: SBO:0000185
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_7207a5df_1335_4525_a3cc_f0ed425cce6a
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: PKLR
boundary condition: true
is encoded by: hsa:5313
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_d5f2da4a_c8e0_4096_b231_35171d263062
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4351
is: P34949
type: Species
boundary condition: true
name: MPI
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_770fa0f7_6a86_4d3a_8f4c_1caf9372c092
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI990637
name: _AI990637_1_x
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM cs e deg3 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00127
type: Species
notes: FORMULA: C37H53NO44S4 CHARGE: -6
is: CHEBI:15748
has only substance units: false
initial amount: NaN

metaR PCHOL HSter
name: phosphatidylcholine scramblase
fast: false
product: MODEL1310110028#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true

metaR HESTRATRIOLtr
name: hydroxylated estrogen derivative transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
reversible: true
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000

metaR NDPK3
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:CDP)
product: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false

metaR CYOR u10m
fast: false
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: ubiquinol-6 cytochrome c reductase, Complex III
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110028#
modifier: MODEL1310110028#

metaM clpnd e
initial amount: NaN
has only substance units: false
name: clupanodonic acid
is: SBO:0000247
type: Species
is: HMDB06528
initial concentration: 1.0
constant: false
is: CHEBI:53488
boundary condition: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaR r0541
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
type: Reaction
modifier: MODEL1310110028#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110028#

metaM cit c
is: CHEBI:16947
is: C00158
is: HMDB00094
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0

metaR HEXCt
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110028#

metaR 4MOPte
fast: false
reversible: true
name: Transport of 4-methyl-2-oxopentanoate
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
is described by: ECO:0000134
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction

metaR MEVK1x
reactant: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
is version of: http://identifiers.org/ec-code/2.7.1.36
type: Reaction
kinetic law: MODEL1310110028#
name: mevalonate kinase (atp)
is described by: ECO:0000134
fast: false
product: MODEL1310110028#

metaM lys L m
is: CHEBI:32551
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: L-lysinium(1+)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_74697324_f221_4db8_8046_baca9b0587e2
constant: false
boundary condition: true
is encoded by: hsa:1806
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: DPYD
is: Q12882
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_41d571e5_348b_4412_b86a_0e6a839dcd69
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:50
is: Q99798
is: SBO:0000252
initial amount: NaN
name: ACO2
has only substance units: false

metaM ivcrn c
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: isovaleryl carnitine
notes: FORMULA: C12H23NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: HMDB00688

metaR NDPK4
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP)
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM sphs1p r
constant: false
type: Species
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
initial amount: NaN
has only substance units: false

metaR GLYCTO1p
is: SBO:0000176
name: Glycolate oxidase, peroxisome
product: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.3.15
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
type: Reaction

metaM dgtp n
is: HMDB01440
constant: false
is: SBO:0000247
initial amount: NaN
name: dGTP
type: Species
is: C00286
initial concentration: 1.0
has only substance units: false
is: CHEBI:16497
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false

metaM 4ppcys c
initial concentration: 1.0
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
constant: false
initial amount: NaN
is: SBO:0000247
is: C04352
has only substance units: false
is: HMDB01117
boundary condition: false
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: CHEBI:59458

metaM mlthf m
is: HMDB01533
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
name: 5,10-Methylenetetrahydrofolate
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00143
is: CHEBI:15636

metaM strdnc e
name: stearidonic acid C18:4, n-3
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB06547
boundary condition: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205608

metaR FACOAL200
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
product: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
name: fatty-acid--CoA ligase

metaM ptdcacrn c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
type: Species
is: CHEBI:18303
constant: false
name: pendtadenoyl carnitine

metaM subeac x
has only substance units: false
name: suberic acid
notes: FORMULA: C8H12O4 CHARGE: -2
is: SBO:0000247
is: HMDB00893
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaM 12ppd S c
boundary condition: false
is: HMDB06213
is: CHEBI:29002
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: (S)-propane-1,2-diol
constant: false
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
has only substance units: false

metaR F1PGT
fast: false
modifier: MODEL1310110028#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
name: fucose-1-phosphate guanylyltransferase
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.30
reversible: true

metaR C162OHc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ea49ab88_b7c4_4f69_9c78_897b135e20be
is: Q92781
is: SBO:0000252
constant: false
type: Species
name: RDH5
is encoded by: hsa:5959
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM ocde9ecoa x
name: 9-octadecenoylcoa
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
initial amount: NaN
type: Species

metaR r0715
type: Reaction
reversible: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/6.3.2.5
is: SBO:0000176
reactant: MODEL1310110028#
fast: false

metaR NDPK1
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
name: nucleoside-diphosphate kinase (ATP:GDP)
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR FACOAL203
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_bd16532c_9d6f_4882_9a4b_2704add0429f
has only substance units: false
initial concentration: NaN
name: _AI694761_1_c
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI694761
type: Species
is: SBO:0000252
constant: false

metaR G16MT U
is described by: ECO:0000000
type: Reaction
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
reversible: false
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110028#
is: SBO:0000176

metaM amp r
initial concentration: 1.0
has only substance units: false
name: AMP
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
is: C00020
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:456215

http://identifiers.org/biomodels.db/MODEL1310110028#_2b189af9_8e13_4843_845d_2a342f135ce2
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55967
name: NDUFA12
is: F8VQS7

metaR ACOAD9m
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000269
modifier: MODEL1310110028#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is: SBO:0000176
product: MODEL1310110028#
fast: false

metaM tethex3coa x
name: tetracosahexaenoyl coenzyme A
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205478
is: SBO:0000247
is: C16168
constant: false
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
initial amount: NaN
initial concentration: 1.0
is: HMDB06243
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_d20d58d5_f855_4a63_98dd_0d4b0543a776
boundary condition: true
constant: false
name: NT5E
type: Species
initial amount: NaN
is encoded by: hsa:4907
is: P21589
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR FAOXC161C141x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_29ac9769_c9b8_46d3_bfbf_490c41b39caf
is: SBO:0000252
is encoded by: hsa:6821
name: SUOX
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: P51687

metaR NDPK2
reactant: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP)
product: MODEL1310110028#
reversible: true
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_192676e5_6128_494f_9d9f_3e6e11e25e21
name: ND5
constant: false
initial concentration: NaN
is: SBO:0000252
is: P03915
type: Species
boundary condition: true
is encoded by: hsa:4540
has only substance units: false
initial amount: NaN

metaR r0714
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110028#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110028#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
type: Reaction

metaR Q10H2e
is described by: ECO:0000134
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reactant: MODEL1310110028#
name: transport of ubiquinol into lymph
is: SBO:0000185
reversible: true

metaR FRDPtcr
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
reactant: MODEL1310110028#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
type: Reaction
product: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110028#_e18a2f52_f741_488d_a17b_2b4534bd846a
type: Species
name: ST3GAL3
is encoded by: hsa:6487
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_b877b844_b121_477f_b7d6_920377d73f01
is: SBO:0000252
is encoded by: hsa:276
has only substance units: false
is: Q6NSB3
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: AMY1A
initial concentration: NaN

metaR APAT2rm
is: SBO:0000176
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.19
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000212
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_170f8f2c_b898_47fb_bf7f_f5c9255a641e
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:64841
is: Q96EK6
name: GNPNAT1
initial concentration: NaN

metaM strdnc c
initial concentration: 1.0
constant: false
name: stearidonic acid C18:4, n-3
has only substance units: false
initial amount: NaN
is: HMDB06547
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205608
type: Species
is: C16300
boundary condition: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793

metaM c4crn x
has only substance units: false
is: SBO:0000247
is: C02862
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
constant: false
boundary condition: false
is: HMDB02013
initial amount: NaN
notes: FORMULA: C11H21NO4 CHARGE: 0
name: butyryl carnitine

http://identifiers.org/biomodels.db/MODEL1310110028#_c1046c96_8f34_47a8_bb0f_5e778733851c
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:10599
name: SLCO1B1
is: Q9Y6L6
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaM g1m8mpdol U r
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: CHEBI:59093
initial concentration: 1.0
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR r0717
type: Reaction
fast: false
reactant: MODEL1310110028#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reversible: false
product: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_b6262f97_1170_4e69_87bb_8ff448d3c775
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51079
boundary condition: true
is: SBO:0000252
has only substance units: false
name: NDUFA13
constant: false
is: Q9P0J0
type: Species

metaR RE1532M
name: RE1532
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_5899841a_bec9_4451_b7ce_3e76af6d14bf
type: Species
is: SBO:0000252
name: ABCB4
is encoded by: hsa:5244
has only substance units: false
constant: false
boundary condition: true
is: P21439
initial concentration: NaN
initial amount: NaN

metaR C162OHe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_d11bec0f_7ae2_4b60_a0dc_5515cf622c57
is encoded by: hsa:23539
constant: false
type: Species
initial amount: NaN
boundary condition: true
name: SLC16A8
initial concentration: NaN
is: SBO:0000252
is: O95907
has only substance units: false

metaR S6TASE24ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110028#
type: Reaction

metaM pheacgln e
initial concentration: 1.0
is: HMDB06344
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
boundary condition: false
initial amount: NaN

metaR PRISTANALtx
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: pristanal peroxisomal transport
reactant: MODEL1310110028#
fast: false
reversible: true
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_99858d3e_4a70_49c0_8e5f_2479dfccefc8
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10400
name: PEMT
initial concentration: NaN
initial amount: NaN
constant: false

metaR EX c81crn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ef18e893_b1a7_496a_aaa9_a282d2261277
is: SBO:0000252
is encoded by: hsa:2679
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: GGT3P

metaR r0545
type: Reaction
fast: false
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
is described by: ECO:0000000
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is: SBO:0000176
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM glu5p m
name: L-Glutamate 5-phosphate
is: SBO:0000247
is: CHEBI:58274
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
is: HMDB01228

metaM prostgd2 r
type: Species
initial concentration: 1.0
constant: false
name: prostaglandin D2(1-)
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
is: CHEBI:57406
is: HMDB01403

metaR FACOAL205
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110028#
kinetic law: MODEL1310110028#
name: fatty-acid--CoA ligase
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110028#

metaR r0716
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
reversible: false
product: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_3ec58b6f_a438_4459_8ab3_9fe0123349e0
name: ETFA
type: Species
is: P13804
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:2108
is: SBO:0000252
initial concentration: NaN

metaR G14T19g
is: SBO:0000176
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110028#
reversible: false
type: Reaction
modifier: MODEL1310110028#

metaR RTOTAL2t
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110028#
name: RTOTAL2 transport
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_11a9a9eb_6e39_48ab_a47b_0c7decc56db6
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PDE9A
has only substance units: false
constant: false
is encoded by: hsa:5152

metaM forglu c
is: SBO:0000247
initial concentration: 1.0
is: HMDB00854
is: CHEBI:18327
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
has only substance units: false
is: C00439
boundary condition: false
initial amount: NaN
constant: false
name: N-Formimidoyl-L-glutamate
type: Species

metaM 2dr1p c
boundary condition: false
is: CHEBI:58576
initial concentration: 1.0
initial amount: NaN
constant: false
name: 2-Deoxy-D-ribose 1-phosphate
is: HMDB01351
has only substance units: false
is: SBO:0000247
is: C00672
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672

metaM docosahexcoa m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/24892790
name: 3,7,10,13,16,19-docosahexenoylcoa
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false

metaR FACOAL204
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110028#_9525c68d_cd67_4dcb_8a67_2a730e2cb988
is encoded by: hsa:5167
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: ENPP1
is: P22413

metaR SUCOASm
reactant: MODEL1310110028#
is: SBO:0000176
fast: false
product: MODEL1310110028#
name: Succinate--CoA ligase (ADP-forming)
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_827bc943_0a1c_4788_85ca_705809cce62c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:767
name: CA8
is: P35219
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_7d23a380_1036_4092_8ad8_51167444f1bd
is: SBO:0000252
boundary condition: true
is: P14555
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5320
constant: false
type: Species
name: PLA2G2A
initial amount: NaN

metaM mi1p D n
initial amount: NaN
name: 1D-myo-inositol 1-phosphate(2-)
constant: false
is: HMDB02985
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:58433
is: SBO:0000247

metaM cit e
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
name: citrate(3-)
boundary condition: false
is: HMDB00094
initial amount: NaN
is: CHEBI:16947
type: Species
has only substance units: false
is: SBO:0000247
constant: false

metaM octdececrn m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
is: HMDB06351
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
has only substance units: false

metaM udpacgal l
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00304
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: SBO:0000247
is: CHEBI:57847

metaR r0718
reactant: MODEL1310110028#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
modifier: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.181
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
reversible: false

metaR GLU5Km
is version of: http://identifiers.org/ec-code/1.2.1.41
name: glutamate 5-kinase (m)
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
is described by: ECO:0000254
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
fast: false
reversible: false
type: Reaction

metaM ivcrn e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
name: isovaleryl carnitine
notes: FORMULA: C12H23NO4 CHARGE: 0
is: SBO:0000247
is: HMDB00688
type: Species

metaM fad m
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
name: Flavin adenine dinucleotide oxidized
type: Species
initial amount: NaN
is: C00016
initial concentration: 1.0
is: HMDB01248

metaR r0885
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
kinetic law: MODEL1310110028#

metaM hpyr c
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:17180
is: SBO:0000247
is: HMDB01352
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
type: Species
boundary condition: false
initial concentration: 1.0
name: 3-hydroxypyruvate

http://identifiers.org/biomodels.db/MODEL1310110028#_7068489f_2735_4939_910e_fe22495b99ee
boundary condition: true
initial concentration: NaN
constant: false
name: HK1
is encoded by: hsa:3098
is: SBO:0000252
is: A8K7J7
initial amount: NaN
type: Species
has only substance units: false

metaR FACOAL206
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
name: fatty-acid--CoA ligase
reversible: true
reactant: MODEL1310110028#

metaR LEUKTRD4t
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
name: leukotriene D4 transport

http://identifiers.org/biomodels.db/MODEL1310110028#_d9f715e8_850b_4705_bbb5_48e9befa9d8c
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3284
initial amount: NaN
boundary condition: true
has only substance units: false
is: P26439
type: Species
name: HSD3B2

metaR r1922
modifier: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
reactant: MODEL1310110028#

metaM fad e
type: Species
name: Flavin adenine dinucleotide oxidized
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: C00016
is: HMDB01248
is: CHEBI:16238
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_d5a8da9c_68db_4ad1_baf3_76e70ea60831
is: G3XA95
boundary condition: true
name: PPAP2A
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8611
initial concentration: NaN
type: Species

metaM dgtp e
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: dGTP
is: HMDB01440
constant: false
is: CHEBI:16497

metaR ECOAH1m
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.18
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
type: Reaction
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
reversible: true
is described by: ECO:0000304

metaM lys L e
type: Species
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:32551
is: HMDB00182
initial amount: NaN
has only substance units: false
constant: false

metaM c4crn m
type: Species
name: butyryl carnitine
boundary condition: false
initial concentration: 1.0
is: HMDB02013
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
constant: false
is: C02862
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0

metaM ksii core2 pre6 g
type: Species
initial amount: NaN
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 6
constant: false
notes: FORMULA: C61H98N5O46SX CHARGE: -2
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM bhb m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: (R)-3-hydroxybutyrate
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011

metaR FAOXC163C164Gm
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_d168f86f_f70c_4564_a2e7_283b0cd50416
initial amount: NaN
has only substance units: false
is encoded by: hsa:55568
name: GALNT10
is: Q86SR1
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

metaR ESTRADIOLtr
reactant: MODEL1310110028#
name: estradiol intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_fb6ada3c_c7e6_46ee_ad50_148da899373a
constant: false
name: INPPL1
has only substance units: false
initial amount: NaN
is: O15357
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:3636

http://identifiers.org/biomodels.db/MODEL1310110028#_e4810fc6_83dd_487f_b46f_dd2a0c2c0d01
name: PPA2
boundary condition: true
initial amount: NaN
is encoded by: hsa:27068
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is: F8WDN9
has only substance units: false

metaR HMGCOARc
is: SBO:0000176
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
modifier: MODEL1310110028#
reversible: false
type: Reaction
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000134
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol

metaR LNLNCACRNt
name: transport into the mitochondria (carnitine)
fast: false
is: SBO:0000185
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110028#
type: Reaction
reversible: false
product: MODEL1310110028#

metaM prist c
constant: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial concentration: 1.0
has only substance units: false
name: pristanic acid
boundary condition: false
is: HMDB00795
type: Species
initial amount: NaN
is: CHEBI:51340
is: SBO:0000247

metaM 3aib D m
has only substance units: false
is: HMDB02299
constant: false
boundary condition: false
name: D-3-Amino-isobutanoate
type: Species
initial concentration: 1.0
is: C03265
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715

http://identifiers.org/biomodels.db/MODEL1310110028#_b37982c4_e75c_43c1_87d7_c62e05f9083e
boundary condition: true
is: SBO:0000252
is: P54868
is encoded by: hsa:3158
type: Species
initial amount: NaN
name: HMGCS2
initial concentration: NaN
constant: false
has only substance units: false

metaM cdp e
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB01546
constant: false
is: CHEBI:58069
name: CDP(3-)
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR FAOXC163C164x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR r1377
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000

metaM itp c
type: Species
name: ITP(3-)
boundary condition: false
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
is: SBO:0000247
is: HMDB00189
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_93bfc27d_8db6_4362_a74d_8f24bcbe0916
initial amount: NaN
name: ALDH3B1
type: Species
is: SBO:0000252
is encoded by: hsa:221
initial concentration: NaN
is: P43353
has only substance units: false
boundary condition: true
constant: false

metaM noncoa m
is: SBO:0000247
constant: false
is: HMDB13028
has only substance units: false
initial amount: NaN
boundary condition: false
name: nonanoylcoa
initial concentration: 1.0
is: C01942
type: Species
notes: FORMULA: C30H48N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110028#_78123eb4_d40d_4258_b3ac_42856fe41f3b
is: SBO:0000252
initial concentration: NaN
constant: false
is: P54802
is encoded by: hsa:4669
boundary condition: true
has only substance units: false
type: Species
name: NAGLU
initial amount: NaN

metaR r0434
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

metaM ksi deg31 l
initial concentration: 1.0
is: CHEBI:57455
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 31
is: HMDB01354

metaM dgtp c
is: CHEBI:16497
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: dGTP
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
is: C00286
constant: false

metaR r0995
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110028#

metaM pail345p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:57836

metaR TETHEX3t
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
is: SBO:0000185
type: Reaction

metaR DURIt
type: Reaction
reactant: MODEL1310110028#
name: deoxyuridine transport via diffusion
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
product: MODEL1310110028#

metaM pheacgln c
has only substance units: false
boundary condition: false
type: Species
is: HMDB06344
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: SBO:0000247
is: CHEBI:58310

metaM dcamp c
type: Species
is: SBO:0000247
is: CHEBI:57567
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
is: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP
has only substance units: false
constant: false
is: HMDB00536
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_ac73b120_c11f_4ecb_af2d_171dedb72175
initial amount: NaN
name: _AI191472_1_c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:AI191472
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6fcb4424_625e_45ef_927d_144f08bb32be
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _U52111_1_c
type: Species
is encoded by: hsa:U52111
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_c2729218_7bab_4ab9_9266_b1557f9bcb2d
has only substance units: false
constant: false
name: ITPA
boundary condition: true
is: Q9BY32
initial concentration: NaN
type: Species
is encoded by: hsa:3704
initial amount: NaN
is: SBO:0000252

metaM nmn c
constant: false
boundary condition: false
name: NMN
type: Species
is: CHEBI:14649
initial concentration: 1.0
is: HMDB00229
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: SBO:0000247
is: C00455

metaR r1924
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaR RE1517M
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110028#
name: RE1517
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
type: Reaction
fast: false
reversible: true

metaR C181CPT1
fast: false
name: transport of Octadecenoyl-CoA into mitochondrial matrix
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
reactant: MODEL1310110028#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
is described by: ECO:0000269
modifier: MODEL1310110028#

metaR r1378
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
fast: false
product: MODEL1310110028#

metaR GLCNACASE5ly
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_35d0adf9_92ab_4d52_9b9d_771fe083e704
constant: false
name: ALDH6A1
is encoded by: hsa:4329
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q02252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_be17e805_5d99_44e0_b6b1_5b4a550ffc04
initial amount: NaN
is: A6NED0
constant: false
name: GSTZ1
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2954
is: SBO:0000252
boundary condition: true

metaR FAOXTC122TC101m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR S6TASE13ly
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR r0994
name: Facilitated diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110028#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_07ddf650_b1f9_4058_a107_f9c9379d1ec7
type: Species
initial amount: NaN
is encoded by: hsa:5279
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: PIGC
initial concentration: NaN

metaM itp e
is: CHEBI:57614
boundary condition: false
name: ITP(3-)
is: SBO:0000247
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

metaM ha l
has only substance units: false
name: hyaluronan
initial concentration: 1.0
constant: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: CHEBI:16336
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR UREAt
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
name: Urea transport via facilitate diffusion
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR

metaM fpram c
is: CHEBI:58478
initial amount: NaN
initial concentration: 1.0
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
is: SBO:0000247
constant: false
has only substance units: false
is: C04640
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
type: Species
boundary condition: false
is: HMDB06211

http://identifiers.org/biomodels.db/MODEL1310110028#_3a02b239_9520_4374_8691_577c66422bed
initial amount: NaN
name: NNT
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: Q13423
is encoded by: hsa:23530

metaM ha e
initial amount: NaN
constant: false
is: SBO:0000247
name: hyaluronan
type: Species
has only substance units: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: CHEBI:16336
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_a198f434_0bf9_44b4_a84e_5b5da5ba2dba
boundary condition: true
initial concentration: NaN
is: Q96SL4
is encoded by: hsa:2882
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: GPX7
is: SBO:0000252

metaM pristanal c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: pristanal
has only substance units: false
is: CHEBI:49189
constant: false
type: Species
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
initial amount: NaN
is: HMDB01958

http://identifiers.org/biomodels.db/MODEL1310110028#_5d6cdbc3_fab1_49cd_8cfe_05b953a707a4
boundary condition: true
has only substance units: false
is: Q9UN42
constant: false
type: Species
name: ATP1B4
is: SBO:0000252
is encoded by: hsa:23439
initial amount: NaN
initial concentration: NaN

metaM dhap e
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB01473
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
name: glycerone phosphate(2-)
is: CHEBI:57642
type: Species
boundary condition: false
constant: false
initial concentration: 1.0

metaR r0822
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110028#

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR HMGCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
is described by: ECO:0000000
product: MODEL1310110028#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#

metaR VALtec
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: L-valine transport via diffusion (extracellular to cytosol)
type: Reaction
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
fast: false

metaR DOLPMT1 Uer
fast: false
reversible: false
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.258
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is described by: ECO:0000000

metaR FAOXC2051843m
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110028#
name: Beta oxidation of fatty acid
reversible: false
fast: false
modifier: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR OCD11CRNCACT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR SGPL12r
name: Sphingosine-1-phosphate lyase
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000304
modifier: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.27
reversible: false

metaM ca2 c
type: Species
boundary condition: false
is: HMDB00464
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:29108
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)

http://identifiers.org/biomodels.db/MODEL1310110028#_1858e662_39fd_4588_b829_3488ec006047
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:477
name: ATP1A2
constant: false
type: Species
initial amount: NaN
is: P50993

http://identifiers.org/biomodels.db/MODEL1310110028#_a97ef962_e202_4b09_8494_f2e830fb10b6
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:1103
name: CHAT
is: D3DX95
constant: false
is: SBO:0000252

metaM 7dhchsterol r
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17759
has only substance units: false
is: HMDB00032
name: cholesta-5,7-dien-3beta-ol
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
type: Species
boundary condition: false

metaR MAL Ltx
reversible: true
name: Transport reaction for malate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
product: MODEL1310110028#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaR NDPK6n
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110028#
modifier: MODEL1310110028#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
fast: false
reversible: true
is described by: ECO:0000304

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaM udpacgal g
boundary condition: false
has only substance units: false
is: HMDB00304
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_ade65612_1efb_4cf2_8089_47f348efe9b9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:53
constant: false
name: ACP2
is: E9PCI1

metaM hs deg12 l
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01352
initial concentration: 1.0
is: CHEBI:17180
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
name: heparan sulfate, degradation product 12

metaR r0821
is: SBO:0000185
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110028#
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaR C181CPT2
name: transport of Octadecenoyl-CoA into mitochondrial matrix
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_3385257d_9106_4818_847a_52b4a0fdd812
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: Q08499
boundary condition: true
is encoded by: hsa:5144
initial concentration: NaN
name: PDE4D

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaR THRGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
name: L-threonine/glycine reversible exchange
fast: false
product: MODEL1310110028#

metaR UMPK2n
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: UMP kinase (CTP),nuclear

metaR NDPK6m
product: MODEL1310110028#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_33440a2c_8fa9_4f7e_80a3_2d569ba0b92f
is: Q9NVE7
type: Species
constant: false
name: PANK4
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:55229
is: SBO:0000252

metaM cit m
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00094
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
boundary condition: false
is: CHEBI:16947
constant: false
is: C00158
initial concentration: 1.0

metaR VALTA
is version of: http://identifiers.org/ec-code/2.6.1.42
name: valine transaminase
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reversible: true
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110028#

metaM cspg e e
initial amount: NaN
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
constant: false
is: CHEBI:16040
type: Species
is: SBO:0000247
is: HMDB00630
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
has only substance units: false
boundary condition: false

metaM ksi deg20 l
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:12936
name: keratan sulfate I, degradation product 20
constant: false
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_e99ac5f1_d012_4b86_af34_e56ca5f1a3cf
constant: false
name: ACOX3
is encoded by: hsa:8310
has only substance units: false
boundary condition: true
is: O15254
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM dhap c
is: SBO:0000247
initial amount: NaN
is: HMDB01473
boundary condition: false
is: CHEBI:57642
type: Species
name: Dihydroxyacetone phosphate
initial concentration: 1.0
is: C00111
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3411

metaM fad c
has only substance units: false
name: Flavin adenine dinucleotide oxidized
is: C00016
type: Species
initial concentration: 1.0
is: HMDB01248
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
is: CHEBI:16238
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_1996a3b6_9028_416d_9c72_66a682917e5d
name: _AI926493_1_c
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI926493
initial amount: NaN
boundary condition: true

metaM datp n
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species
initial concentration: 1.0
name: dATP
constant: false
is: HMDB01532
has only substance units: false
is: SBO:0000247
is: C00131
is: CHEBI:61404
initial amount: NaN
boundary condition: false

metaR AMETr
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
name: S-Adenosyl-L-methionine intracellular diffusion
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
is: SBO:0000185

metaR SGALSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
name: sgalside hs intracellular transport
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110028#

metaM Ser Gly Ala X Gly l
is: SBO:0000247
is: CHEBI:36005
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: HMDB02183
name: protein-linked serine residue (glycosaminoglycan attachment site)
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_3452a2f6_7f12_45f4_b628_83ffa48096d9
type: Species
name: AHCY
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:191
is: B3KUN3

metaM lys L c
is: SBO:0000247
is: HMDB00182
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
is: CHEBI:32551
boundary condition: false
name: L-lysinium(1+)
initial amount: NaN
type: Species

metaR S6T14g
reactant: MODEL1310110028#
product: MODEL1310110028#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is: SBO:0000176
modifier: MODEL1310110028#
type: Reaction
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_f6563c5f_f793_4a92_b5dc_348aab73a366
is encoded by: hsa:2348
boundary condition: true
initial amount: NaN
has only substance units: false
name: FOLR1
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR r0276
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is: SBO:0000176
modifier: MODEL1310110028#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.21

http://identifiers.org/biomodels.db/MODEL1310110028#_0b6cd3b1_8709_40a2_be53_3cb35b720aab
constant: false
type: Species
name: PIK3C3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5289
initial amount: NaN
is: Q8NEB9
initial concentration: NaN
boundary condition: true

metaR r0999
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
reversible: true
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#

metaR r0998
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
reactant: MODEL1310110028#
name: Facilitated diffusion
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_5c08a9df_c5d7_410b_a80a_2a342e87f3f0
constant: false
is: P17812
boundary condition: true
is encoded by: hsa:1503
initial amount: NaN
type: Species
name: CTPS1
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR DMNONCRNt
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
fast: false
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110028#
type: Reaction

metaM amp m
boundary condition: false
is: HMDB00045
is: SBO:0000247
constant: false
name: AMP(2-)
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

http://identifiers.org/biomodels.db/MODEL1310110028#_e2b5699f_974c_44cc_858b_cc3669661bff
initial concentration: NaN
is encoded by: hsa:131669
is: Q68CJ7
constant: false
type: Species
is: SBO:0000252
name: UROC1
boundary condition: true
has only substance units: false
initial amount: NaN

metaM man6p c
boundary condition: false
constant: false
is: HMDB01078
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:17369
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
name: D-Mannose 6-phosphate

metaM c81coa c
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: HMDB03949
is: C05276
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
initial concentration: 1.0
name: octenoylcoa

metaR DDECE1CRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaM datp m
type: Species
constant: false
is: CHEBI:61404
initial concentration: 1.0
name: dATP
has only substance units: false
is: HMDB01532
is: SBO:0000247
is: C00131
initial amount: NaN
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6c2edcb1_bfc7_4c0c_8b5a_85adc027cbc3
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1608
is: P49619
constant: false
name: DGKG
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r1929
modifier: MODEL1310110028#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

metaR FAOXC80
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: Beta oxidation of med/long chain fatty acid
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269

metaM cdp c
type: Species
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
is: SBO:0000247
is: HMDB01546
is: CHEBI:58069
initial concentration: 1.0
name: CDP
is: C00112
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_d3f11c4e_d819_4a40_b31e_47405511586a
name: NDUFV3
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4731
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true

metaR EX acgam LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-D-glucosamine exchange
type: Reaction

metaR SPHK21c
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
fast: false
reversible: false
modifier: MODEL1310110028#
name: sphingosine kinase 2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.91
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction

metaR S23T3g
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.6
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
modifier: MODEL1310110028#
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
reversible: false
product: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_dbc8ff28_d9a5_4e7d_a23c_28bb892e6cc2
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q53XN1
name: COX8A
is encoded by: hsa:1351
constant: false

metaR DPPS
type: Reaction
reversible: false
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
is described by: ECO:0000134
is: SBO:0000176
name: decaprenyl synthase

metaR KSII CORE2t
fast: false
name: keratan sulfate II (core2) transport, golgi to extracellular
is described by: ECO:0000000
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_5f7c88d8_79d3_4f9f_bd81_b9ca5f0af2e9
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:56895
is: SBO:0000252
type: Species
name: AGPAT4
is: Q9NRZ5
constant: false
initial amount: NaN

metaR ARACHCPT2
type: Reaction
modifier: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase

metaM ump n
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: UMP(2-)
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
is: CHEBI:57865
is: HMDB00288
has only substance units: false

metaM udpacgal c
is: HMDB00304
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
constant: false
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
is: CHEBI:57847
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR r0129
is: SBO:0000176
modifier: MODEL1310110028#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
type: Reaction
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
product: MODEL1310110028#

metaR r2079
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r1380
type: Reaction
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
is: SBO:0000176
reversible: true

metaR NRVNCt
fast: false
is described by: ECO:0000000
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaM ump m
has only substance units: false
initial concentration: 1.0
name: UMP(2-)
is: HMDB00288
initial amount: NaN
constant: false
boundary condition: false
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
is: CHEBI:57865

metaR HDECEACBP
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaR S6T4g
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110028#

metaM dhap x
constant: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: C00111
is: CHEBI:57642
has only substance units: false
name: Dihydroxyacetone phosphate
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01473

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM ksii core4 pre6 g
constant: false
has only substance units: false
is: CHEBI:28067
type: Species
name: keratan sulfate II biosynthesis, precursor 6
notes: FORMULA: C69H111N6O51SX CHARGE: -2
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR PI45P5P
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
modifier: MODEL1310110028#
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
kinetic law: MODEL1310110028#
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.36

http://identifiers.org/biomodels.db/MODEL1310110028#_988cd477_be92_42b5_a85b_393a2b51ed05
is encoded by: hsa:29085
is: SBO:0000252
type: Species
is: Q9P019
initial concentration: NaN
has only substance units: false
name: PHPT1
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_7db1dc59_a9de_4481_bfa5_a62731dbe4fd
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:7108
boundary condition: true
is: O76062
initial concentration: NaN
initial amount: NaN
constant: false
name: TM7SF2

metaM akg e
initial concentration: 1.0
boundary condition: false
name: 2-oxoglutarate(2-)
is: HMDB00208
constant: false
is: CHEBI:16810
type: Species
initial amount: NaN
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
is: SBO:0000247

metaR NTD3
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dCMP)
fast: false
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110028#
is: SBO:0000176
reversible: false

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
reversible: true
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
kinetic law: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110028#

metaR NDPK5n
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110028#
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear

metaM ca2 e
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: SBO:0000247
type: Species
name: calcium(2+)
has only substance units: false
is: CHEBI:29108
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00464
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_b02b362f_14bc_4efe_a445_e1f21e4ea051
name: AMT
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:275
is: P48728
type: Species
is: SBO:0000252
boundary condition: true

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_e5d0a023_d813_48d8_9d30_4239e0f84b6d
name: MYO5B
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q9H6Y6
has only substance units: false
is encoded by: hsa:4645
boundary condition: true
type: Species
constant: false

metaR CYSGLYexR
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
reactant: MODEL1310110028#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
name: L-cysteine/glycine reversible exchanger
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_eb49bcba_0f1b_430b_b839_38a079d4306c
initial concentration: NaN
boundary condition: true
is: B4DZR2
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: ALDH1A2
is encoded by: hsa:8854

metaR RE2814M
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
name: RE2814
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:

metaR MG1er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.106
reversible: false
is described by: ECO:0000000

metaR NTD5
fast: false
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
type: Reaction
name: 5'-nucleotidase (dTMP)
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134
reversible: false
is: SBO:0000176
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR PEPCKm
reversible: false
name: Phosphoenolpyruvate carboxykinase (GTP)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
product: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.1.1.32
type: Reaction
is: SBO:0000176
reactant: MODEL1310110028#
fast: false

metaM pe hs c
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:16038
name: phosphatidylethanolamine

metaM formcoa c
name: formyl-CoA(4-)
is: HMDB03419
is: CHEBI:57376
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_85b4aa56_4b63_43e2_aedc_15d32b5973f9
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q16718
constant: false
has only substance units: false
is encoded by: hsa:4698
name: NDUFA5
boundary condition: true

metaR PAPStg
reactant: MODEL1310110028#
name: 3'-Phosphoadenylyl sufate Golgi transport
reversible: true
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
kinetic law: MODEL1310110028#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110028#

metaM m8masn r
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
is: SBO:0000247
is: C05876
constant: false
notes: FORMULA: C70H117N2O55X CHARGE: 0
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false

metaR PPCDC
is version of: http://identifiers.org/ec-code/4.1.1.36
reversible: false
product: MODEL1310110028#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
name: phosphopantothenoylcysteine decarboxylase
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_72498f02_fb3b_40db_9043_cfde07c52fae
is: P00325
type: Species
is encoded by: hsa:125
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ADH1B
constant: false

metaM didp c
is: HMDB03536
boundary condition: false
constant: false
is: CHEBI:28823
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
type: Species
name: dIDP
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR LEUKTRA4t
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
name: leukotriene A4 transport
reactant: MODEL1310110028#
fast: false
reversible: true

metaM lpam m
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial concentration: 1.0
is: HMDB00962
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: lipoamide
is: CHEBI:17460
is: SBO:0000247
constant: false

metaR r0281
reversible: true
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
type: Reaction
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.6
is: SBO:0000176
reactant: MODEL1310110028#

metaR NACHEX11ly
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110028#

metaR r0817
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
fast: false
modifier: MODEL1310110028#

metaR SGALSIDEtg
name: sgalside hs intracellular transport
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110028#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
reversible: true
product: MODEL1310110028#

metaM cs e deg6 l
is: HMDB01354
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:57455
is: SBO:0000247
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3

metaR r1662
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110028#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM CE5118 m
type: Species
constant: false
is: CHEBI:57923
boundary condition: false
has only substance units: false
is: SBO:0000247
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
initial amount: NaN

metaR 3SALAOX
type: Reaction
reversible: false
product: MODEL1310110028#
is described by: ECO:0000000
name: cysteinesulfinic acid oxidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:as described in Bender (Nutritional biochmeistry of the vitamins, 2nd edition) MM
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#

metaR MGSA2
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
is: SBO:0000176
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: methyglyoxylate synthase 2 (from g3p)
reversible: false
type: Reaction

metaR HDCACBP
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_3032a3d2_79d4_43df_a95a_bddc9e30ad97
name: ADH1A
is: P07327
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:124
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

metaR OROTGLUt
name: OROTGLUt
kinetic law: MODEL1310110028#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110028#
fast: false

metaM akg c
is: HMDB00208
is: CHEBI:16810
constant: false
name: 2-Oxoglutarate
is: C00026
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247

metaM ump r
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
is: HMDB00288
has only substance units: false
name: UMP
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57865
is: SBO:0000247
boundary condition: false

metaM fru c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial amount: NaN
name: D-Fructose
type: Species
constant: false
is: CHEBI:15824
is: HMDB00660
is: SBO:0000247
has only substance units: false
is: C00095
boundary condition: false
initial concentration: 1.0

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_70c5b0c5_7f21_429f_ad5a_f45e1ab98621
initial amount: NaN
type: Species
name: CMPK1
constant: false
has only substance units: false
is: B2R6S5
is encoded by: hsa:51727
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM pe hs e
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16038
name: phosphatidylethanolamine
type: Species

metaR ACt2m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
name: acetate mitochondrial transport via proton symport
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#
type: Reaction

metaM dece3coa m
name: 3-decenoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r0818
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaM maltpt e
is: HMDB01296
constant: false
initial amount: NaN
boundary condition: false
is: C02052
initial concentration: 1.0
is: SBO:0000247
name: maltopentaose
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: http://identifiers.org/pubchem.compound/5141
type: Species
has only substance units: false

metaR r1661
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false
reversible: true
reactant: MODEL1310110028#

metaR r1384
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
reversible: true
name: Guanosine aminohydrolase EC:3.5.4.15
reactant: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
kinetic law: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_9a2a6e73_1355_4003_89ed_116246f49dcc
is: Q8IZH9
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: GCH1
type: Species
is encoded by: hsa:2643
boundary condition: true

metaM amp c
name: AMP
has only substance units: false
type: Species
constant: false
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2
initial amount: NaN
is: SBO:0000247
is: CHEBI:3322
is: C00020
boundary condition: false
initial concentration: 1.0

metaR FTCD
reversible: false
is described by: ECO:0000134
name: formimidoyltransferase cyclodeaminase
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
is version of: http://identifiers.org/ec-code/2.1.2.5
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR NDPK10n
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
is described by: ECO:0000304
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
fast: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110028#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_3bafcc39_d2c6_458d_b8da_69131b9429c8
is: O95168
is encoded by: hsa:4710
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: NDUFB4
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaR DECDICRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR ACOAD1fm
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is version of: http://identifiers.org/ec-code/1.3.8.1
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
reactant: MODEL1310110028#
reversible: false
type: Reaction
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
product: MODEL1310110028#

metaM his L m
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: CHEBI:15971
is: HMDB00177
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR RE2814R
reactant: MODEL1310110028#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110028#
type: Reaction
name: RE2814
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000

metaR NTD8
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction
modifier: MODEL1310110028#
name: 5'-nucleotidase (dGMP)
fast: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
reversible: false

metaR r1660
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_94cf0fd7_dc24_40bc_b16c_383d0e273f6d
type: Species
is encoded by: hsa:501
is: E7EPT3
name: ALDH7A1
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r0819
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
modifier: MODEL1310110028#
is described by: ECO:0000000

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR PRASCS
is: SBO:0000176
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110028#
reversible: true
is described by: ECO:0000269
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
type: Reaction

metaM man l
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: D-mannose
is: CHEBI:16024

metaR PACCOAL
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110028#
name: phenylacetate-CoA ligase
type: Reaction
product: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_20555ebf_61b8_4eef_bbca_055b0b9fe7dd
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: NDUFA6
initial amount: NaN
is: P56556
is encoded by: hsa:4700

metaM ficytC m
name: Ferricytochrome c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
type: Species
has only substance units: false
is: CHEBI:15991

metaM cspg e l
initial concentration: 1.0
boundary condition: false
is: CHEBI:36005
initial amount: NaN
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
type: Species
constant: false
is: HMDB02183
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_02e78f09_d318_483f_91e4_2a95f2585d6e
is encoded by: hsa:D87002
initial concentration: NaN
boundary condition: true
type: Species
constant: false
initial amount: NaN
name: _D87002_1_e
has only substance units: false
is: SBO:0000252

metaR r0437
fast: false
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176

metaR HYXNt
is described by: ECO:0000269
modifier: MODEL1310110028#
name: Hypoxanthine transport
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
type: Reaction
product: MODEL1310110028#
reversible: true
is: SBO:0000185
reactant: MODEL1310110028#

metaM fru e
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
constant: false
type: Species
is: HMDB00660
is: CHEBI:15824
is: SBO:0000247
name: D-Fructose
is: C00095
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR r0990
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#
name: Postulated transport reaction
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110028#
fast: false

metaM dhbpt c
initial amount: NaN
is: HMDB00038
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:20680
boundary condition: false
name: 6,7-dihydrobiopterin
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_bd20e938_88ab_4c67_8b12_6333a170d8b9
name: ABAT
is encoded by: hsa:18
is: P80404
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR 4HOXPACDOX NADP
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000304
fast: false
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM amp e
initial concentration: 1.0
name: AMP
has only substance units: false
type: Species
constant: false
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
initial amount: NaN
is: SBO:0000247
is: C00020
boundary condition: false

metaR EX sl L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-sulfolactate exchange
type: Reaction

metaM prostgd2 c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: prostaglandin D2(1-)
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
is: CHEBI:57406
type: Species
constant: false

metaM 44mzym r
is: CHEBI:18364
constant: false
has only substance units: false
name: 14-demethyllanosterol
type: Species
is: HMDB01286
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial concentration: 1.0
boundary condition: false

metaM 2octdectecoa x
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
name: 2,6,9,12-octadecatetraenoylcoa

metaM core3 g
is: SBO:0000247
constant: false
is: CHEBI:16250
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Core 3
notes: FORMULA: C16H27N2O10X CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_2746ed5e_0e8c_43e7_908d_67246b06949c
initial amount: NaN
boundary condition: true
name: TKTL2
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q9H0I9
constant: false
is encoded by: hsa:84076

http://identifiers.org/biomodels.db/MODEL1310110028#_a9dc2194_41c8_42b3_b7a5_9bc49da757c4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:127
constant: false
has only substance units: false
is: P08319
type: Species
boundary condition: true
initial amount: NaN
name: ADH4

http://identifiers.org/biomodels.db/MODEL1310110028#_c300dcbc_a660_4da7_9334_de1c10a5acf2
type: Species
constant: false
is: E9PB82
name: HSD17B4
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3295

http://identifiers.org/biomodels.db/MODEL1310110028#_d537db76_222e_48f5_8776_dc70dd116d42
is: F8W7V3
initial concentration: NaN
is: SBO:0000252
name: ATP5J2
boundary condition: true
initial amount: NaN
is encoded by: hsa:9551
constant: false
has only substance units: false
type: Species

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_020d87b4_3013_4764_a015_24c34dd507c7
is: Q9NVS9
constant: false
is: SBO:0000252
name: PNPO
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:55163

metaR NaKt
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
is described by: ECO:0000269
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
type: Reaction
name: Na+/K+ exchanging ATPase
is version of: http://identifiers.org/ec-code/3.6.3.9
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
is: SBO:0000185

metaR FAOXC10C8x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM drib c
has only substance units: false
is: CHEBI:28816
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: HMDB03224
initial concentration: 1.0
constant: false
type: Species
name: 2-deoxy-D-ribose
boundary condition: false

metaR FAOXC2051843x
modifier: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaM hs deg2 l
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
is: CHEBI:17180
is: SBO:0000247
name: heparan sulfate, degradation product 2
has only substance units: false
is: HMDB01352
constant: false
type: Species
boundary condition: false

metaR DTDPtn
name: dTDP nuclear transport
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is: SBO:0000185
type: Reaction

metaM hexde7coa x
has only substance units: false
initial concentration: 1.0
is: HMDB02288
boundary condition: false
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
initial amount: NaN
name: 7-hexadecenoylcoa
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_b4d5d79a_6b1d_4e7e_b6cc_6edcc2914e8a
type: Species
is: SBO:0000252
name: ST3GAL3
has only substance units: false
is encoded by: hsa:6487
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaM galside hs l
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
boundary condition: false
initial concentration: 1.0

metaM dece3coa x
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: 3-decenoylcoa
has only substance units: false
initial concentration: 1.0
type: Species

metaR r1666
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_e04add4f_95c7_4664_a9b0_bb94ba9fb201
initial amount: NaN
constant: false
initial concentration: NaN
name: _LOC647190_1_c
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:LOC647190
is: SBO:0000252

metaR GLNtm
product: MODEL1310110028#
is: SBO:0000185
type: Reaction
reversible: false
name: L-glutamine transport via electroneutral transporter
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
is described by: ECO:0000000
fast: false

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR AKGt4 3
reversible: true
name: AKG transport via sodium symport
type: Reaction
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (64849.1) or (64849.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10099705,PMID:10794676 NOTES:NCD
reactant: MODEL1310110028#
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_bba1d816_7889_4c36_a5f5_986884ee8c31
boundary condition: true
initial amount: NaN
has only substance units: false
is: O14556
constant: false
initial concentration: NaN
name: GAPDHS
is encoded by: hsa:26330
is: SBO:0000252
type: Species

metaR G14T20g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
reversible: false

metaR LEUKTRA4tr
name: leukotriene intracellular transport
reactant: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false
product: MODEL1310110028#

metaR FAOXC164C163x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaR FAOXC161C141m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_52d1b789_ce53_44b4_a669_3d9d7859d995
name: NT5C3
type: Species
initial concentration: NaN
boundary condition: true
is: Q9H0P0
is encoded by: hsa:51251
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaM HC00319 c
type: Species
name: Malonate
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
is: CHEBI:30794
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR HSAT4ly
is: SBO:0000185
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
fast: false

metaM h2o2 x
boundary condition: false
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: SBO:0000247
type: Species
name: Hydrogen peroxide
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: C00027
is: CHEBI:16240

metaR 5MTHFt
product: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
reversible: true
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
type: Reaction

metaM man e
constant: false
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
type: Species
is: C00159
name: D-Mannose
is: SBO:0000247
has only substance units: false
is: HMDB00169
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_6f69d55c_affd_4bc6_b59d_d3d061bb7aca
constant: false
name: IDH2
is encoded by: hsa:3418
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P48735
initial amount: NaN
is: SBO:0000252

metaM prostgd2 e
is: HMDB01403
type: Species
is: SBO:0000247
name: prostaglandin D2(1-)
constant: false
is: CHEBI:57406
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
initial amount: NaN

metaR r1665
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#
modifier: MODEL1310110028#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110028#

metaM ump e
constant: false
is: CHEBI:57865
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP(2-)
has only substance units: false
is: HMDB00288
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r0549
modifier: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000176
fast: false
product: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/1.6.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/6.1.1.17
is version of: http://identifiers.org/ec-code/1.6.5.3
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
reactant: MODEL1310110028#

metaR AKR1D2
is: SBO:0000176
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.1.3
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reversible: false
kinetic law: MODEL1310110028#

metaR MI1345PP
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
reversible: false
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000269
modifier: MODEL1310110028#
fast: false

metaR C4STMO1r
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.72
reactant: MODEL1310110028#
product: MODEL1310110028#

metaM drib e
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:28816
is: HMDB03224
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
name: 2-deoxy-D-ribose

metaR r0881
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110028#
name: Active transport
type: Reaction
reversible: false

metaM 3dphb m
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06251
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
constant: false
has only substance units: false
name: 3-Decaprenyl-4-hydroxybenzoate
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_681cd6e6_c9a9_4508_b060_53b78c9266b1
initial concentration: NaN
constant: false
is: SBO:0000252
name: _R33828_1_c
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:R33828
initial amount: NaN

metaM m4masn g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C46H77N2O35X CHARGE: 0
is: C05881
type: Species
constant: false
has only substance units: false
boundary condition: false

metaM 4izp c
is: SBO:0000247
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57255
is: HMDB01014
type: Species
initial concentration: 1.0
initial amount: NaN
name: 4-Imidazolone-5-propanoate

metaR r1664
name: Y+LAT2 Utilized transport
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_85f0972b_7e7d_47aa_a9bf_34e5df5afe40
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:4705
boundary condition: true
has only substance units: false
name: NDUFA10
initial amount: NaN
is: O95299

metaR ACt2r
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reversible: true
product: MODEL1310110028#
fast: false
name: acetate reversible transport via proton symport
reactant: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_88500593_48fa_44d7_af5e_eb5d0fbc02b5
boundary condition: true
name: GALNT9
is encoded by: hsa:50614
is: Q9HCQ5
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaM srtn e
type: Species
name: serotonin(1+)
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00259
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
is: CHEBI:350546
initial concentration: 1.0

metaM CE5160 r
initial concentration: 1.0
type: Species
name: 3-oxo-cis-9-octadecenoyl-CoA
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
constant: false
has only substance units: false
is: CHEBI:57923
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR LCTStg
kinetic law: MODEL1310110028#
fast: false
name: lactose transport from Golgi to extracellular (via vesicle)
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
is described by: ECO:0000000

metaR FACOAL246 1
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110028#
reversible: true
name: fatty-acid--CoA ligase

metaM ump c
initial concentration: 1.0
constant: false
is: CHEBI:57865
type: Species
has only substance units: false
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
boundary condition: false
is: HMDB00288
initial amount: NaN
is: SBO:0000247
is: C00105

metaR NDPK9
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP)
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_8f111ad1_80ec_414f_b8ae_e2da54c17b7e
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: GPX3
is: P22352
is encoded by: hsa:2878
boundary condition: true

metaM man g
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:16024
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
is: SBO:0000247
is: HMDB00169
name: D-mannose

metaR HMGLx
is version of: http://identifiers.org/ec-code/4.1.3.4
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000134
product: MODEL1310110028#
name: hydroxymethylglutaryl-CoA lyase
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
modifier: MODEL1310110028#
reversible: false
type: Reaction
reactant: MODEL1310110028#

metaM m8masn g
initial concentration: 1.0
boundary condition: false
constant: false
is: C05876
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C70H117N2O55X CHARGE: 0
initial amount: NaN
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaR NTD1
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
fast: false
kinetic law: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
name: 5'-nucleotidase (dUMP)
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM doldp U r
initial concentration: 1.0
is: CHEBI:15750
name: Dolichol diphosphate, human uterine homolog
type: Species
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false

metaR RE2541E
reactant: MODEL1310110028#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.31
name: RE2541
modifier: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_31abddad_6c2f_4ecd_a1c1_fc2662b091ad
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: RHBG
is: Q9H310
is encoded by: hsa:57127

metaR EX ivcrn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaM 3sala m
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
type: Species
is: C00606
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 3-sulfino-L-alanine (1-)
is: CHEBI:61085
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_13ddc300_b26c_4511_b02a_51ae9dce3f6a
initial concentration: NaN
has only substance units: false
is encoded by: hsa:113
name: ADCY7
type: Species
constant: false
is: P51828
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR NDPK8
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dADP)
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reactant: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
kinetic law: MODEL1310110028#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_59051376_8efc_4094_a386_953e7954ff4d
is: SBO:0000252
constant: false
name: ALG3
initial amount: NaN
is: Q92685
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10195
type: Species

metaR 2MB2COAc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_32870ace_6f30_4472_9b8f_a68a8f01aa9b
type: Species
constant: false
name: SLC2A10
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:81031
has only substance units: false
is: O95528

metaM srtn c
is: CHEBI:350546
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: serotonin(1+)
is: HMDB00259
has only substance units: false
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
is: SBO:0000247

metaM pe hs m
is: CHEBI:16038
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine

metaR ORNt4m
fast: false
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000185
name: ornithine mitochondrial transport exchange with citruline
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
product: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR DOLMANP Lter
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
product: MODEL1310110028#
name: dolichol-phosphate mannose flippase (liver)
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110028#

metaR NDPK7
kinetic law: MODEL1310110028#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphate kinase (ATP:dCDP)
fast: false
is: SBO:0000176
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction

metaM octdececrn c
initial concentration: 1.0
type: Species
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06351
notes: FORMULA: C25H47NO4 CHARGE: 0

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_8acdd5d9_ffef_4e1f_a4de_eed3f68f390b
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:131
name: ADH7
is: P40394

metaR r1669
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
type: Reaction

metaR DHORD9
reversible: false
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is version of: http://identifiers.org/ec-code/1.3.5.2
is described by: ECO:0000269
product: MODEL1310110028#
modifier: MODEL1310110028#
name: dihydoorotic acid dehydrogenase (quinone10)

metaR GGH 6DHFe
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000

metaR MMEm
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
product: MODEL1310110028#
type: Reaction
name: methylmalonyl-CoA epimerase/racemase
is version of: http://identifiers.org/ec-code/5.1.99.1
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110028#_aa67903e_2606_48af_b28d_149815152704
name: PPT1
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q6FGQ4
type: Species
initial concentration: NaN
is encoded by: hsa:5538

metaM 7dhchsterol c
has only substance units: false
initial amount: NaN
is: HMDB00032
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
name: cholesta-5,7-dien-3beta-ol
is: CHEBI:17759
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR DHCR71r
product: MODEL1310110028#
name: 7-dehydrocholesterol reductase
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000134
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is version of: http://identifiers.org/ec-code/1.3.1.21

metaM c6dc x
is: SBO:0000247
name: adipoyl carnitine
has only substance units: false
initial concentration: 1.0
type: Species
is: C14143
boundary condition: false
notes: FORMULA: C13H22NO6 CHARGE: -1
is: HMDB04047
constant: false
initial amount: NaN

metaR r1668
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110028#
fast: false
reversible: true
reactant: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_e0d91812_92e6_463f_888a_9b32d91e23f8
is encoded by: hsa:113452
constant: false
type: Species
name: TMEM54
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q969K7
has only substance units: false

metaR NDPK6
is described by: ECO:0000269
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110028#
fast: false
name: Nucleoside-diphosphate kinase (ATP:dUDP)
reversible: true
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_873e5d80_9188_44ee_af27_21cbd0958ea0
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:9791
is: SBO:0000252
is: P48651
initial concentration: NaN
name: PTDSS1
initial amount: NaN

metaR ARACHCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110028#
fast: false
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110028#
name: carnitine transferase
reversible: false
kinetic law: MODEL1310110028#

metaR S3TASE3ly
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000176

metaM man c
is: C00159
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: HMDB00169
name: D-Mannose
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16024

metaM ump g
has only substance units: false
constant: false
is: SBO:0000247
name: UMP(2-)
boundary condition: false
type: Species
is: CHEBI:57865
initial amount: NaN
initial concentration: 1.0
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR TRIODTHYt2
kinetic law: MODEL1310110028#
is described by: ECO:0000269
modifier: MODEL1310110028#
name: T3 transport via facilitated diffusion
reactant: MODEL1310110028#
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_3f8c1da1_f155_4a03_b118_54552e518e1e
name: RDH16
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:8608
type: Species
is: O75452
constant: false
initial amount: NaN
initial concentration: NaN

metaR AG13T11g
reactant: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110028#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction

metaM succ c
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
name: Succinate
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00042
initial amount: NaN
type: Species
is: HMDB00254

http://identifiers.org/biomodels.db/MODEL1310110028#_48828c2b_dc49_4550_b915_62d2335382c9
name: PIK3R1
is: E7EX19
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5295
has only substance units: false
initial amount: NaN

metaR 34DHPLACOX NADP
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
reversible: true
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110028#_4af3e0ef_7548_4ca6_81a1_271531155af4
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:124
boundary condition: true
has part: P07327
type: Species
constant: false
has only substance units: false
name: ADH1A:ADH1B
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_e31e4b36_d8e0_4ed0_9de5_170f498bf17a
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:47
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ACLY

metaR r1667
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#

metaR NDPK5
reversible: true
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dGDP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
product: MODEL1310110028#
kinetic law: MODEL1310110028#

W3 CDTF: Thu Aug 30 20:20:41 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110028#_8a6dc611_8047_4e15_8421_1c8cd8864134
name: NDUFB7
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4713
has only substance units: false
constant: false
is: P17568
is: SBO:0000252

metaM adp r
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
name: ADP(3-)
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01341
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_716db65e_53bb_4af1_84ef_75bc0096584a
initial concentration: NaN
is: P11166
is encoded by: hsa:6513
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: SLC2A1
has only substance units: false

metaR r1659
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM o2s m
initial concentration: 1.0
name: Superoxide anion
is: C00704
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: HMDB02168
is: SBO:0000247

metaR RE3568C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110028#
name: RE3568
reversible: true
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_7fb2593a_425b_47c9_ba98_2d058a46c7cb
is: SBO:0000252
is encoded by: hsa:2592
initial amount: NaN
name: GALT
type: Species
initial concentration: NaN
is: E7ET32
boundary condition: true
has only substance units: false
constant: false

W3 CDTF: Thu Aug 30 20:20:41 BST 2012

metaM n2m2nmasn l
type: Species
boundary condition: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: C04946
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C58H96N5O40X CHARGE: 0
has only substance units: false

metaM h2o l
is: SBO:0000247
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB02111
boundary condition: false
type: Species
name: water

metaM pe hs r
has only substance units: false
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
type: Species
name: phosphatidylethanolamine
is: CHEBI:16038
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_35f4c6cd_1f4b_4c8d_ac7b_30fe768b758d
has only substance units: false
initial concentration: NaN
is encoded by: hsa:476
has part: P54709
type: Species
has part: B7Z3U6
is: SBO:0000297
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:483
name: ATP1A1:ATP1B3

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM hs l
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:28815
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, free chain
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
boundary condition: false
type: Species

metaR MTHFC
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methenyltetrahydrofolate cyclohydrolase
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110028#_70ecad12_e628_44aa_b42a_724203e37ad2
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR VACCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
type: Reaction
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110028#

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ee92b618_1eda_45c4_9b1d_5192867ba877
initial concentration: NaN
type: Species
is encoded by: hsa:4700
is: P56556
constant: false
has only substance units: false
initial amount: NaN
name: NDUFA6
boundary condition: true
is: SBO:0000252

metaM prgnlones c
initial amount: NaN
boundary condition: false
is: CHEBI:35420
constant: false
name: pregnenolone sulfate
type: Species
is: SBO:0000247
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
initial concentration: 1.0
is: HMDB00774
has only substance units: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR PI345P5P
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is: SBO:0000176
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
reactant: MODEL1310110028#
is described by: ECO:0000000
fast: false
product: MODEL1310110028#

metaR UMPK3n
product: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110028#
fast: false
name: UMP kinase (UTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR r0553
reversible: true
is: SBO:0000176
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_37d27d78_4327_4161_bea2_cf42df85f958
name: SDS
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10993
initial amount: NaN
is: P20132

http://identifiers.org/biomodels.db/MODEL1310110028#_5d9ff9ef_a76a_4d4e_9ca4_c3ff1053988d
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:51
boundary condition: true
initial concentration: NaN
name: ACOX1
is: SBO:0000252
is: B4DK61

metaM hs deg9 l
boundary condition: false
is: HMDB06355
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
is: CHEBI:18268
name: heparan sulfate, degradation product 9
constant: false
is: SBO:0000247

metaR r0879
reversible: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
reactant: MODEL1310110028#

metaM uri e
initial amount: NaN
constant: false
is: SBO:0000247
name: Uridine
is: HMDB00296
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
is: C00299
initial concentration: 1.0

metaM akg x
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
constant: false
is: HMDB00208
type: Species
has only substance units: false
name: 2-oxoglutarate(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_7726d2d9_de43_40ba_9d82_52277de54c5c
initial concentration: NaN
name: CRAT
constant: false
has only substance units: false
is: P43155
is encoded by: hsa:1384
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_5842326d_79a8_453f_b3d0_e07402f9d3cb
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:3295
is: E9PB82
boundary condition: true
name: HSD17B4
initial concentration: NaN

metaR GLYCt
reactant: MODEL1310110028#
type: Reaction
reversible: true
kinetic law: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
name: glycerol transport via channel
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
fast: false
is: SBO:0000185

metaR FAOXC150m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
reversible: false
reactant: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid (odd chain)
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ

metaM pydxn c
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
is: HMDB00239
name: Pyridoxine
boundary condition: false
is: CHEBI:16709
constant: false
type: Species
initial concentration: 1.0
is: C00314
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR 3SALAASPm
kinetic law: MODEL1310110028#
name: cysteinesulfinate-aspartate mitochondrial shuttle
reactant: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
is described by: ECO:0000304
reversible: true
is: SBO:0000185

metaR S6TASE26ly
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_6f57c31d_9dae_47d0_ba75_d001244ffeeb
name: MTMR3
is: Q13615
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:8897
boundary condition: true
initial concentration: NaN

metaR r0552
is: SBO:0000176
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
type: Reaction
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.5.1
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
modifier: MODEL1310110028#

metaR FUMTSULtm
type: Reaction
reactant: MODEL1310110028#
name: Fumarate:thiosulfate antiport, mitochondrial
kinetic law: MODEL1310110028#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110028#
fast: false
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR RE1531M
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110028#
name: RE1531
kinetic law: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_b239141b_d74e_4a63_bdd0_ee6f3adebf8b
has only substance units: false
is: B1AM93
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: NDUFA8
is: SBO:0000252
is encoded by: hsa:4702
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_939eec76_7298_4473_a001_a51a7661a5fc
initial amount: NaN
is encoded by: hsa:6901
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: Q16635
initial concentration: NaN
type: Species
name: TAZ

metaR r0707
is version of: http://identifiers.org/ec-code/2.3.1.168
product: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1

metaM acnam l
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: N-acetylneuraminate
is: HMDB00230
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: CHEBI:35418

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR HDDACBP
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ca06f1bb_01ea_40a4_9556_6a1096e9075d
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P00441
constant: false
has only substance units: false
type: Species
is encoded by: hsa:6647
name: SOD1

metaM adp n
initial amount: NaN
is: HMDB01341
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
has only substance units: false
name: ADP(3-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_61fe6def_e143_470d_ac4a_5a0a354fd098
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: AK4
is encoded by: hsa:205
boundary condition: true
initial concentration: NaN
type: Species

metaM glyb c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17750
boundary condition: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
has only substance units: false
is: HMDB00043
name: glycine betaine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6874baaf_dd1d_48cd_be33_f8dfe7fc76bf
has only substance units: false
type: Species
is encoded by: hsa:3177
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q14542
is: SBO:0000252
constant: false
name: SLC29A2

http://identifiers.org/biomodels.db/MODEL1310110028#_f0c6eddb_3183_4858_8afe_80f47fee6c11
is: B3KUK6
type: Species
is encoded by: hsa:93034
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: NT5C1B

metaR G14T18g
fast: false
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR r0706
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
modifier: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.10
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR MTHFD
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5
name: methylenetetrahydrofolate dehydrogenase (NADP)
fast: false
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is: SBO:0000176
product: MODEL1310110028#

metaR GCC2cm
name: glycine-cleavage complex (lipoamide), mitochondrial
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110028#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.1.2.10
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR VACCCPT1
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

metaR FAOXC7C5m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaM HC00342 m
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
name: cis-aconitate(3-)
is: CHEBI:16383
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417

metaM h2o g
is: SBO:0000247
type: Species
boundary condition: false
name: water
is: CHEBI:15377
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02111

metaR q10tm
fast: false
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110028#
name: transport of ubiquinone into mitochondria
kinetic law: MODEL1310110028#
is described by: ECO:0000134
type: Reaction

metaR r1933
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110028#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110028#
reversible: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE2626M
is version of: http://identifiers.org/ec-code/1.14.13.15
name: RE2626
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
reversible: true
modifier: MODEL1310110028#

metaM digalside hs l
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
name: Digalactosylceramide
boundary condition: false
has only substance units: false
is: C06126
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/8383

http://identifiers.org/biomodels.db/MODEL1310110028#_e55f599d_21da_48ce_8523_a9c4a6e494b5
constant: false
name: HADHB
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: P55084
initial amount: NaN
has only substance units: false
is encoded by: hsa:3032

metaM dcmp n
is: SBO:0000247
is: HMDB01202
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:57566
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP(2-)
boundary condition: false

metaM adp m
is: C00008
is: HMDB01341
is: CHEBI:456216
is: http://identifiers.org/pubchem.compound/3310
has only substance units: false
name: ADP
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

W3 CDTF: Thu Aug 30 20:20:42 BST 2012

metaM pail5p hs c
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57795
constant: false

metaM acnam n
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00230
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: CHEBI:35418
constant: false
initial amount: NaN

metaR RE1518M
is: SBO:0000176
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
type: Reaction
name: RE1518
modifier: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110028#

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_5edcc350_a539_4810_921d_5d0d8a1ca309
initial amount: NaN
is encoded by: hsa:2653
is: SBO:0000252
is: P23434
constant: false
type: Species
has only substance units: false
initial concentration: NaN
name: GCSH
boundary condition: true

metaR r0557
is: SBO:0000176
kinetic law: MODEL1310110028#
fast: false
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
reactant: MODEL1310110028#
reversible: false
product: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_ccbd4b26_8720_4e21_8843_a647ecf289bb
is encoded by: hsa:518
type: Species
initial amount: NaN
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: P48201
has only substance units: false
initial concentration: NaN
is: SBO:0000297
constant: false

metaR FAOXC164C165x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_18ca6da4_45ed_4cd3_8026_811aad74a39e
initial concentration: NaN
is encoded by: hsa:6568
is: SBO:0000252
type: Species
initial amount: NaN
name: SLC17A1
has only substance units: false
boundary condition: true
constant: false
is: Q14916

metaR ADRNt
is: SBO:0000185
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#
type: Reaction
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

metaR OCTDECCACT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM dhea c
is: HMDB00077
initial concentration: 1.0
name: 3beta-hydroxyandrost-5-en-17-one
type: Species
is: SBO:0000247
is: CHEBI:28689
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_2e6d3bfe_d86c_4fe9_a19d_08db8a482cae
boundary condition: true
initial amount: NaN
has only substance units: false
name: NDUFA5
is: SBO:0000252
initial concentration: NaN
is: Q16718
type: Species
constant: false
is encoded by: hsa:4698

metaR r0556
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.14.19.1
product: MODEL1310110028#
reactant: MODEL1310110028#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000176

metaR MDHx
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
name: malate dehydrogenase, peroxisomal
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
is: SBO:0000176

metaM h2o e
initial concentration: 1.0
is: C00001
name: H2O
boundary condition: false
constant: false
type: Species
is: HMDB02111
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
has only substance units: false
is: CHEBI:15377

metaM tmndnccrn m
constant: false
is: HMDB12130
initial amount: NaN
name: Timnodonyl carnitine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
is: CHEBI:16987

metaM prist x
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
name: pristanic acid
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00795
is: CHEBI:51340

http://identifiers.org/biomodels.db/MODEL1310110028#_860f42c7_67b1_4d8f_bfe6_9a4b5055ab52
constant: false
is: Q9NYW8
initial amount: NaN
has only substance units: false
name: RBAK
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:57786
is: SBO:0000252

metaM tyr L e
name: L-tyrosine
constant: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00158
boundary condition: false

metaR FAOXC246226x
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:6 -> c22:6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
type: Reaction
kinetic law: MODEL1310110028#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR M13N2Tg
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.101
is: SBO:0000176

metaM o2s e
type: Species
initial amount: NaN
is: HMDB02168
name: superoxide
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
is: SBO:0000247
is: CHEBI:18421
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_28646117_f1b6_48d6_85e6_991fde0a5d53
initial amount: NaN
type: Species
is: SBO:0000252
name: PPT2
is: Q9UMR5
initial concentration: NaN
is encoded by: hsa:9374
boundary condition: true
has only substance units: false
constant: false

metaR GGH 6THFe
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
reactant: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is: SBO:0000176
type: Reaction
name: Gamma-glutamyl hydrolase (6THF), extracellular
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR XYLtly
fast: false
reversible: false
product: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110028#
name: Xylose efflux from lysosome
type: Reaction
reactant: MODEL1310110028#

metaR FAOXC9C7m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaM thp2c c
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: CHEBI:16987
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 1-piperideine-6-carboxylate
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB12130

metaM glu L c
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
boundary condition: false
is: CHEBI:29985
type: Species
is: HMDB00148
initial amount: NaN
constant: false
is: SBO:0000247
name: L-glutamate(1-)

http://identifiers.org/biomodels.db/MODEL1310110028#_df9ea382_0298_4efb_82d1_043f1dd68bb3
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: B3GNT8
boundary condition: true
is encoded by: hsa:374907
has only substance units: false
is: Q7Z7M8

metaM betald c
name: betaine aldehyde
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: HMDB01252
has only substance units: false
initial concentration: 1.0
is: CHEBI:15710

metaM hdca e
boundary condition: false
has only substance units: false
type: Species
is: HMDB00220
is: SBO:0000247
name: Hexadecanoate (n-C16:0)
is: CHEBI:0
notes: FORMULA: C16H31O2 CHARGE: -1
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00249

metaM akg m
is: C00026
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
constant: false
initial amount: NaN
boundary condition: false
name: 2-Oxoglutarate
has only substance units: false
is: CHEBI:16810
initial concentration: 1.0
is: HMDB00208
type: Species

metaR DM atp c
is: SBO:0000176
name: DM_atp(c)
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110028#
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaM h2o c
initial concentration: 1.0
is: SBO:0000247
constant: false
name: H2O
notes: FORMULA: H2O CHARGE: 0
type: Species
initial amount: NaN
is: CHEBI:3303
is: HMDB02111
has only substance units: false
boundary condition: false
is: C00001

http://identifiers.org/biomodels.db/MODEL1310110028#_afc66053_0630_4244_a88a_b64c06901628
name: ACSM1
initial concentration: NaN
boundary condition: true
constant: false
is: Q08AH1
has only substance units: false
is encoded by: hsa:116285
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_3a6b9150_fe76_48d4_a342_1204ee681f60
boundary condition: true
has only substance units: false
is encoded by: hsa:93034
name: NT5C1B
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q96P26
type: Species
constant: false

metaM tyr L c
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00158
name: L-tyrosine
initial amount: NaN
constant: false
is: CHEBI:17895
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

http://identifiers.org/biomodels.db/MODEL1310110028#_34ce66c7_0a46_475f_b387_7c382f5838d3
type: Species
is: O14880
name: MGST3
is encoded by: hsa:4259
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252

metaR FAOXC61C4m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM 4ppan c
boundary condition: false
is: HMDB01016
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: C03492
constant: false
name: D-4'-Phosphopantothenate
type: Species
is: CHEBI:10986
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM o2s c
name: superoxide
type: Species
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
initial concentration: 1.0
is: HMDB02168
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18421

metaM n2m2nmasn e
constant: false
initial concentration: 1.0
is: C04946
is: SBO:0000247
has only substance units: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species
initial amount: NaN
boundary condition: false

metaM 3hbcoa m
is: CHEBI:57316
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB01166
boundary condition: false
is: SBO:0000247
has only substance units: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144

metaR RE1573M
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reactant: MODEL1310110028#
is: SBO:0000176
name: RE1573
fast: false
type: Reaction
kinetic law: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
modifier: MODEL1310110028#
product: MODEL1310110028#

metaM ksi pre9 g
name: keratan sulfate I biosynthesis, precursor 9
boundary condition: false
is: C00130
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: CHEBI:58053
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00175

metaR PRODt2r
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
name: D-proline reversible transport via proton symport
is described by: ECO:0000304
fast: false
type: Reaction
reactant: MODEL1310110028#
reversible: true
product: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR GRTTx
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
is described by: ECO:0000134
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.5.1.1
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
name: geranyltranstransferase
product: MODEL1310110028#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_9b2abc75_ff98_4318_a950_fe182905593e
name: ACOX1
is encoded by: hsa:51
initial amount: NaN
is: SBO:0000252
is: B4DK61
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaM 4hphac e
type: Species
is: HMDB00020
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
name: 4-hydroxyphenylacetate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:48999
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_14d12e5d_3b0e_4b6f_b45a_f9c8444d98fa
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: AMY1C
is encoded by: hsa:278
is: P04745
constant: false
is: SBO:0000252
boundary condition: true

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM hdca c
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
type: Species
name: palmitate
is: HMDB00220
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:7896

metaR FAOXC14C12x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaM glu L e
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
initial concentration: 1.0
is: CHEBI:29985
boundary condition: false
type: Species
is: HMDB00148
initial amount: NaN
constant: false
is: SBO:0000247

metaR S6T13g
fast: false
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reversible: false
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#

metaM zymstnl r
is: HMDB06841
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
has only substance units: false
initial concentration: 1.0
is: CHEBI:16608
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: 5alpha-cholest-8-en-3beta-ol
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_783dcdbc_d194_43ff_b0f0_d54f9f4bf5d3
boundary condition: true
is: SBO:0000252
is: B4DNK4
constant: false
is encoded by: hsa:5315
initial concentration: NaN
has only substance units: false
name: PKM2
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_fb0ac811_3a8c_46aa_a4ec_f5d3d4c2a9d4
is: SBO:0000252
has only substance units: false
is encoded by: hsa:47
name: ACLY
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P53396
type: Species
constant: false

metaM pail5p hs n
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57795
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR 25HVITD3t
reversible: false
product: MODEL1310110028#
name: 25-hydroxyvitamin D3 transport from cytoplasm
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12045394 NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT. Biochemical
type: Reaction
is: SBO:0000185

metaR HSAT3ly
reversible: false
product: MODEL1310110028#
fast: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110028#

metaR r0813
reversible: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR r1935
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_60850239_8169_4dff_92de_c4531c6d421c
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:23236
boundary condition: true
is: Q9NQ66
name: PLCB1

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_99df5ea8_72e6_4519_ab82_5acf3408b127
type: Species
constant: false
has only substance units: false
is: Q99424
boundary condition: true
name: ACOX2
is encoded by: hsa:8309
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR C161CPT2
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
product: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
is described by: ECO:0000000
type: Reaction
fast: false
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_630d5987_f6e5_4d04_b442_4a1e3086d54f
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:NOS2A
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _NOS2A_1_e
constant: false

metaM m3mpdol U c
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
boundary condition: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
is: CHEBI:37632
initial amount: NaN
type: Species
has only substance units: false

metaR FAOXC18C18OHm
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaM rbt c
constant: false
type: Species
is: CHEBI:15963
is: HMDB00508
is: SBO:0000247
name: D-ribitol
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false
initial concentration: 1.0

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_357f2506_a828_44eb_9854_b03cf3c2e936
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23428
constant: false
name: SLC7A8
has only substance units: false
type: Species
is: Q9UHI5
initial amount: NaN
boundary condition: true

metaR THP2Ctp
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
fast: false
is: SBO:0000185
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110028#
reversible: true

metaR TYRCBOX
product: MODEL1310110028#
fast: false
reversible: false
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
name: L-Tyrosine carboxy-lyase
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.1.28
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_d20ee149_c729_4839_811e_13f103e37d15
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5244
name: ABCB4
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

metaR S4TASE2ly
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
fast: false
reversible: true
reactant: MODEL1310110028#

metaR ACONT
kinetic law: MODEL1310110028#
is: SBO:0000176
name: aconitase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110028#
reversible: true
type: Reaction
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
fast: false
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_3471ac67_15e2_4d38_9091_ca854ba16e2f
constant: false
is: Q02318
initial amount: NaN
is encoded by: hsa:1593
type: Species
boundary condition: true
name: CYP27A1
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR GULNter
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: false
product: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: L-gulonate endoplasmic reticular export
type: Reaction

metaM 4hphac c
is: CHEBI:48999
initial amount: NaN
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
boundary condition: false
initial concentration: 1.0
is: HMDB00020
type: Species
name: 4-hydroxyphenylacetate
has only substance units: false
is: SBO:0000247
constant: false

metaR RE2626C
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110028#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
name: RE2626
product: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#

metaR r0812
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110028#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR ABUTD
reversible: false
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110028#
name: Aminobutyraldehyde dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110028#_d13e1ab4_61b5_42a9_b8ac_37af6d506bf6
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: Q99707
is encoded by: hsa:4548
constant: false
is: SBO:0000252
name: MTR

http://identifiers.org/biomodels.db/MODEL1310110028#_f188ab53_671b_4567_9126_d2e972d4e3fe
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is: E9PB82
has only substance units: false
name: HSD17B4
is encoded by: hsa:3295

http://identifiers.org/biomodels.db/MODEL1310110028#_0197b555_3353_444b_962a_ae45750e7a84
initial amount: NaN
name: ATP1A3
type: Species
is: B7Z2T0
is encoded by: hsa:478
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR NDPK7n
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
modifier: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
fast: false
kinetic law: MODEL1310110028#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_bf884235_3a8a_4ecd_85ef_0dd06263631f
is: SBO:0000252
is encoded by: hsa:64080
type: Species
name: RBKS
has only substance units: false
initial concentration: NaN
is: Q9H477
initial amount: NaN
boundary condition: true
constant: false

metaR r0287
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176

metaR FAOXC164C165m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaR C8CRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_bb873a42_3538_4f28_816e_aa04bbf48612
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: GOT1
initial amount: NaN
constant: false
type: Species
is: P17174
boundary condition: true
is encoded by: hsa:2805

metaM uri c
has only substance units: false
is: C00299
is: HMDB00296
type: Species
is: CHEBI:16704
name: Uridine
boundary condition: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false

metaR SQLSr
is described by: ECO:0000134
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.21
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
is: SBO:0000176
name: Squalene synthase
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM formcoa x
initial amount: NaN
constant: false
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
has only substance units: false
name: formyl-CoA(4-)
is: HMDB03419
boundary condition: false
is: CHEBI:57376
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM digalside hs c
is: http://identifiers.org/pubchem.compound/8383
initial amount: NaN
is: C06126
is: SBO:0000247
has only substance units: false
name: Digalactosylceramide
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126

metaM hspg e
is: CHEBI:32366
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB02259
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
constant: false
type: Species
name: heparan sulfate proteoglycan

metaR CMPSASn
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
name: CMP sialic acid synthase, nuclear
is version of: http://identifiers.org/ec-code/2.7.7.43
is described by: ECO:0000304
reversible: false
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
product: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_796108f5_29e7_42cc_816c_1bf4eb0e3bd0
is: SBO:0000252
is: O75964
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:10632
name: ATP5L
initial amount: NaN

metaM rbt e
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00508
is: CHEBI:15963
initial amount: NaN
name: D-ribitol
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ce020fe6_8020_4870_a2e4_aa530f53806b
constant: false
initial amount: NaN
name: MTHFD2L
has only substance units: false
initial concentration: NaN
is encoded by: hsa:441024
is: SBO:0000252
type: Species
is: Q9H903
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_91690935_a2ec_4ae1_9bac_0be5f64d5cae
type: Species
is encoded by: hsa:5277
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PIGA
initial amount: NaN

metaR SEBACIDTD
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaM guln c
type: Species
name: L-gulonate
is: CHEBI:13115
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: SBO:0000247
constant: false
is: HMDB03290
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_cc488fbc_0e15_4be7_9265_fcb0ae83f0b0
is: SBO:0000252
constant: false
is encoded by: hsa:4512
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q7GXY8
initial concentration: NaN
name: COX1

http://identifiers.org/biomodels.db/MODEL1310110028#_6238188b_b224_4219_9e1c_6ea4674d0ae3
type: Species
name: GALNT7
is: Q86SF2
has only substance units: false
is encoded by: hsa:51809
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

metaM adp c
name: ADP
constant: false
initial concentration: 1.0
type: Species
is: C00008
initial amount: NaN
boundary condition: false
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
is: SBO:0000247
has only substance units: false
is: CHEBI:16761

http://identifiers.org/biomodels.db/MODEL1310110028#_ad24e275_a297_4e43_ad94_42b575c70b70
has only substance units: false
is: O14732
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:3613
initial concentration: NaN
name: IMPA2
constant: false
is: SBO:0000252

metaR C161CPT22
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: C161 transport into the mitochondria
modifier: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000269

metaR r0443
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42

metaR FAOXC16OHC16r
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM thcholoylcoa x
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:27403
is: HMDB12456
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_25fa7bb6_fd2e_40ae_bd5e_807ab1f28edc
initial concentration: NaN
is: Q9NY28
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: GALNT8
type: Species
is encoded by: hsa:26290

http://identifiers.org/biomodels.db/MODEL1310110028#_d960f6f7_c732_48da_b2d3_99a5bf096007
name: PIK3CA:PIK3R2
has only substance units: false
is encoded by: hsa:5290
has part: O00459
boundary condition: true
constant: false
initial concentration: NaN
has part: P42336
type: Species
is encoded by: hsa:5296
initial amount: NaN
is: SBO:0000297

metaR ALAtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110028#
name: Alanine transport (Na, H coupled)
fast: false
reversible: true
type: Reaction
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#

metaR r1939
modifier: MODEL1310110028#
name: Y+LAT2 Utilized transport
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false

metaR r0295
is: SBO:0000176
modifier: MODEL1310110028#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
reactant: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_9e84e7de_ec2d_4739_ad07_f87c7b6c6282
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: SLC14A2
is encoded by: hsa:8170
is: Q15849

http://identifiers.org/biomodels.db/MODEL1310110028#_f7134626_0af7_4b18_aa88_322be603806b
type: Species
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
boundary condition: true

metaR DOPAt4 2 r
type: Reaction
name: Dopamine reversible transport in via sodium symport (1:2)
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110028#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_8037eacb_f557_43da_a674_842dffade646
initial amount: NaN
constant: false
boundary condition: true
is: Q7LG56
initial concentration: NaN
is encoded by: hsa:50484
name: RRM2B
has only substance units: false
type: Species
is: SBO:0000252

metaR HESTRATRIOLte
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ
type: Reaction
is: SBO:0000185
product: MODEL1310110028#
is described by: ECO:0000000
name: hydroxylated estrogen derivative transport

metaR ELAIDCPT2
name: carnitine transferase
modifier: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110028#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_3f909fc9_c30e_4c3e_885e_aee0b95081ad
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR RE3245C
is described by: ECO:0000000
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110028#
type: Reaction
name: RE3245

metaM xolest2 hs e
is: SBO:0000247
initial amount: NaN
name: cholesterol ester
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
boundary condition: false
constant: false
is: CHEBI:17002
initial concentration: 1.0
type: Species
has only substance units: false

metaM mi1p D c
is: SBO:0000247
is: HMDB02985
has only substance units: false
is: CHEBI:58433
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
boundary condition: false
type: Species
name: 1D-myo-inositol 1-phosphate(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a849d700_b203_426c_bccf_c6fc1a22cb28
initial amount: NaN
is encoded by: hsa:AI435857
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: _AI435857_1_x
boundary condition: true

metaM itp n
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
is: CHEBI:57614
type: Species
is: SBO:0000247
boundary condition: false
name: ITP(3-)
is: HMDB00189
initial amount: NaN

metaR HACD9m
kinetic law: MODEL1310110028#
type: Reaction
reversible: true
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
product: MODEL1310110028#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_7a9c4cd8_80e8_41b9_9000_ac38919e28be
is: P47989
name: XDH
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:7498
type: Species
has only substance units: false
is: SBO:0000252

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaR C180CRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
reactant: MODEL1310110028#
name: C180 transport into the mitochondria
is described by: ECO:0000269
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110028#
fast: false

metaR r0139
type: Reaction
reactant: MODEL1310110028#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.2.2
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true

metaM nicrnt c
is: SBO:0000247
is: HMDB01132
is: CHEBI:57502
name: Nicotinate D-ribonucleotide
type: Species
initial amount: NaN
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
constant: false
is: C01185
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaM HC02121 c
has only substance units: false
boundary condition: false
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
initial concentration: 1.0
constant: false

metaM ksi deg15 l
name: keratan sulfate I, degradation product 15
is: CHEBI:12936
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00143
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_fb3d090a_28dc_43fa_99f3_46fbf658c16c
constant: false
is: P07864
is encoded by: hsa:3948
type: Species
initial amount: NaN
name: LDHC
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR PI45P4P
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is: SBO:0000176
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_731f9b74_595f_4343_88bf_2ca7da0e172e
is: SBO:0000252
name: PIGQ
is encoded by: hsa:9091
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: Q9BRB3

metaR ASPDxt
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reactant: MODEL1310110028#
name: D-aspartate transport, peroxisomal
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR S6T5g
fast: false
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110028#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110028#
is described by: ECO:0000000

metaM ksi deg18 l
name: keratan sulfate I, degradation product 18
is: HMDB00143
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:12936
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_fc1812b1_71d4_4175_aa00_d449061e8e6b
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: ATP5J
is: P18859
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:522

metaR GLUTCOAACBP
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of glutaryl-CoA(5-) from mitochondria into cytosol
type: Reaction

metaR r0809
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
reversible: true
reactant: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaM pail3p hs c
is: CHEBI:58088
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR Asn X Ser Thrtr
fast: false
kinetic law: MODEL1310110028#
type: Reaction
name: Asn-X-Ser/Thr transport (from ER to lysosome)
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
reversible: true
is described by: ECO:0000269
is: SBO:0000185

metaR TRDR
is described by: ECO:0000269
reactant: MODEL1310110028#
name: thioredoxin reductase (NADPH)
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.9
type: Reaction

metaM CE2431 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
boundary condition: false
name: cis-deca-4-enoyl-CoA
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57795
initial concentration: 1.0

metaM glu L m
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
is: HMDB00148
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:29985
has only substance units: false
name: L-glutamate(1-)

metaM c4crn e
is: http://identifiers.org/pubchem.compound/213144
name: butyryl carnitine
is: C02862
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: HMDB02013
boundary condition: false
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0

metaM 3tetd7ecoacrn c
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C21H39NO5 CHARGE: 0
is: HMDB02014
name: 3-hydroxy tetradecenoyl-7-carnitine
type: Species

metaM m3emgacpail hs r
is: SBO:0000247
notes: FORMULA: C57H104N2O37P2FULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
boundary condition: false
name: (trimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (M4C)
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:16240
type: Species
is: HMDB03125

http://identifiers.org/biomodels.db/MODEL1310110028#_f1707aab_ff6d_41ca_9beb_5906e6429a07
is: P59796
name: GPX6
constant: false
boundary condition: true
is encoded by: hsa:257202
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR S23T4g
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.99.4
reactant: MODEL1310110028#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110028#
name: beta-galactoside alpha-2,3-sialyltransferase
fast: false
type: Reaction

metaM o2s x
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB02168
is: CHEBI:18421
type: Species
name: superoxide
constant: false

metaM ksi pre21 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 21
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: C00130
is: HMDB00175
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_b84b881b_c16c_4930_ab2b_27febbc192fd
boundary condition: true
initial amount: NaN
constant: false
name: SLC2A9
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:56606
initial concentration: NaN

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR SUCCACT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR GHMT2rm
name: glycine hydroxymethyltransferase, reversible, mitochondrial
kinetic law: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
fast: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.1.2.1
reversible: true

metaR HDCEAtr
product: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185

metaR S6TASE23ly
kinetic law: MODEL1310110028#
fast: false
type: Reaction
product: MODEL1310110028#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
is: SBO:0000176

metaM pep m
is: SBO:0000247
is: CHEBI:18021
initial amount: NaN
name: Phosphoenolpyruvate
is: C00074
initial concentration: 1.0
constant: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
boundary condition: false
is: HMDB00263
type: Species
has only substance units: false

metaM glyc c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00131
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
constant: false
name: Glycerol
is: CHEBI:17754
is: C00116

http://identifiers.org/biomodels.db/MODEL1310110028#_5f7fd287_e200_4d5a_8598_0a948e63b345
is encoded by: hsa:8525
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: G3V0F6
initial amount: NaN
name: DGKZ

http://identifiers.org/biomodels.db/MODEL1310110028#_15bf37cf_5e3f_4164_bdab_6cdab42a5402
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: ACSL3
is: O95573
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2181

metaR HMGCOAtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
fast: false
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_178c82d1_79f6_4554_a712_d08c22805a36
is encoded by: hsa:2983
is: SBO:0000297
is encoded by: hsa:2977
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: GUCY1A2:GUCY1B3
has part: Q02153
initial concentration: NaN
has part: P33402

http://identifiers.org/biomodels.db/MODEL1310110028#_e67689ef_887e_4156_a3f9_b1300d81d7b3
initial amount: NaN
has only substance units: false
is encoded by: hsa:52
type: Species
is: SBO:0000252
name: ACP1
boundary condition: true
initial concentration: NaN
is: Q59EH3
constant: false

metaM hspg l
is: CHEBI:17899
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
constant: false
name: heparan sulfate proteoglycan
type: Species
boundary condition: false
is: HMDB01993
initial amount: NaN
has only substance units: false

metaR RE0452M
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000000
reversible: true
name: RE0452
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176

metaR C161CPT1
modifier: MODEL1310110028#
name: production of palmitoleoylcarnitine
product: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110028#

metaM 3tetd7ecoacrn e
constant: false
name: 3-hydroxy tetradecenoyl-7-carnitine
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C21H39NO5 CHARGE: 0
is: HMDB02014
initial amount: NaN
boundary condition: false

metaM c4crn c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C11H21NO4 CHARGE: 0
is: http://identifiers.org/pubchem.compound/213144
constant: false
type: Species
initial amount: NaN
name: butyryl carnitine
is: C02862
is: HMDB02013
boundary condition: false
is: SBO:0000247

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

metaR PI4P3K
kinetic law: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
name: phosphatidylinositol 4-phosphate 3-kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
product: MODEL1310110028#
modifier: MODEL1310110028#

metaR PI34P5K
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
modifier: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_3c5c7783_b099_473d_a3f2_42fbdd77445f
type: Species
initial concentration: NaN
is: Q9Y6M9
has only substance units: false
constant: false
is: SBO:0000252
name: NDUFB9
is encoded by: hsa:4715
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_8cd7700f_cc68_46db_860e_d8ec84da55bd
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:10449
constant: false
is: P42765
initial concentration: NaN
name: ACAA2
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_b5763fe2_e76c_4d07_8de7_644fd77fc6b5
has only substance units: false
boundary condition: true
is encoded by: hsa:5238
name: PGM3
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: B4DX94

metaR r2064
reversible: false
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110028#

metaM urcan c
initial amount: NaN
boundary condition: false
name: Urocanate
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: CHEBI:17771
type: Species
is: HMDB00301
is: C00785

metaR THYOXt
fast: false
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
type: Reaction
name: T4 transport via bicarbonate countertransport
kinetic law: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ

metaR r1650
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110028#
reversible: true
type: Reaction
modifier: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_64e1ad8e_25ab_4485_92a5_c0b6222ef7ae
boundary condition: true
constant: false
name: MGAT1
initial amount: NaN
type: Species
is: P26572
initial concentration: NaN
is encoded by: hsa:4245
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6ceea97e_5a59_4c98_bdb2_081643c1ce69
type: Species
name: _BE042354_1_m
boundary condition: true
has only substance units: false
is encoded by: hsa:BE042354
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_01c85319_db23_45de_b443_b4aaac4039e9
has only substance units: false
name: _AI653169_1_c
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI653169
initial amount: NaN
boundary condition: true
type: Species

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110028#_d7f272d3_7a48_4d0d_bae2_59eda01e8ec9
is encoded by: hsa:4129
boundary condition: true
name: MAOB
is: P27338
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaM glyc e
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00131
constant: false
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
is: SBO:0000247
name: Glycerol

metaR ELAIDCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine O-palmitoyltransferase
is described by: ECO:0000269
reactant: MODEL1310110028#
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_4b93fed4_ff7f_4afe_a5e0_7932fff8db41
constant: false
is: SBO:0000252
name: LDHB
type: Species
is: P07195
has only substance units: false
boundary condition: true
is encoded by: hsa:3945
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_5e286b3e_9dfb_4fc8_bee6_7dcd3a60aefd
boundary condition: true
name: SLC25A2
is: Q9BXI2
is encoded by: hsa:83884
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaR DOLPMT2 Uer
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
fast: false
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_8934aa3a_425b_40be_a009_cdd617fe08bf
boundary condition: true
constant: false
type: Species
name: PRPS1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5631
initial amount: NaN
is: P60891
has only substance units: false

metaM glu L r
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00148
constant: false
boundary condition: false
name: L-glutamate(1-)
initial concentration: 1.0
is: CHEBI:29985
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025

http://identifiers.org/biomodels.db/MODEL1310110028#_7236c521_399a_4213_8f1d_68374299a851
has only substance units: false
is encoded by: hsa:3707
name: ITPKB
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is: P27987
initial concentration: NaN

metaM c6dc c
is: HMDB00705
initial concentration: 1.0
is: SBO:0000247
name: adipoyl carnitine
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C13H22NO6 CHARGE: -1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_ea461bec_89ec_4a9e_99a3_b8db2e1d280b
is: P40926
has only substance units: false
boundary condition: true
is encoded by: hsa:4191
is: SBO:0000252
name: MDH2
constant: false
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_6e692a34_05c1_4c1d_a472_47c2bdd717b9
boundary condition: true
is: Q99489
name: DDO
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is encoded by: hsa:8528
initial concentration: NaN

metaM lcts g
initial concentration: 1.0
is: HMDB00186
is: SBO:0000247
initial amount: NaN
is: CHEBI:17716
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
name: lactose
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_7096b628_5be6_415e_a645_c7d425203df9
type: Species
has only substance units: false
is: O43916
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:8534
initial concentration: NaN
name: CHST1

metaR CO2tm
is described by: ECO:0000000
reactant: MODEL1310110028#
name: CO2 transport (diffusion), mitochondrial
type: Reaction
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
reversible: true
is: SBO:0000185

metaR GALASE17ly
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is: SBO:0000176
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110028#

metaR r0558
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
reactant: MODEL1310110028#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_39e90a0c_4bd5_4289_abc6_0aa8a0166a8e
has only substance units: false
is encoded by: hsa:8604
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC25A12
initial concentration: NaN
is: O75746
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_5529ab05_7f00_4f5c_9777_099767cc5c31
constant: false
is encoded by: hsa:AW277253
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: _AW277253_1_c
type: Species
is: SBO:0000252
boundary condition: true

metaM HC02216 e
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: CHEBI:28922
name: prostaglandin-f2beta
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1

metaR MG2er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reactant: MODEL1310110028#
reversible: false
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#

metaM cdpea c
boundary condition: false
is: CHEBI:57876
constant: false
is: HMDB01564
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
initial amount: NaN
name: cdpea[c]
has only substance units: false

metaR r0130
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110028#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110028#
product: MODEL1310110028#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reactant: MODEL1310110028#
is: SBO:0000176

metaM tmndnccrn c
notes: FORMULA: C27H43NO4 CHARGE: 0 INCHI: InChI=1/C28H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-28(32)33-26(24-27(30)31)25-29(2,3)4/h6-7,9-10,12-13,15-16,18-19,26H,5,8,11,14,17,20-25H2,1-4H3/t26-/m0/s1
constant: false
initial concentration: 1.0
is: CHEBI:16987
has only substance units: false
is: HMDB12130
initial amount: NaN
boundary condition: false
name: Timnodonyl carnitine
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_c8b83bfe_b313_4587_886d_7ec325e99b4d
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is: B4DUY1
initial concentration: NaN
is encoded by: hsa:10948
name: STARD3
type: Species

metaR ADRNCRNt
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110028#
name: transport into the mitochondria (carnitine)

metaR r1652
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#

metaR r0870
reactant: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.72
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.1
type: Reaction
name: Facilitated diffusion
modifier: MODEL1310110028#
fast: false
is: SBO:0000185
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.3.4
is version of: http://identifiers.org/ec-code/3.6.4.13
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
kinetic law: MODEL1310110028#

metaR HPACtr
name: hydroxyphenylacetate transport via diffusion
reversible: true
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185

metaR G14T21g
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_81590987_8f3d_40fc_8e58_522401f2c88f
is: A8K7W0
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:8875
constant: false
name: VNN2

metaR ORNt3m
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
name: ornithine mitochondrial transport via proton antiport
modifier: MODEL1310110028#
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_0bdd7b24_eea5_49a2_bccb_db743a476b59
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: _AI469183_1_x
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI469183

metaM uri n
is: SBO:0000247
type: Species
is: HMDB00296
is: CHEBI:16704
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
constant: false
initial concentration: 1.0
name: uridine
has only substance units: false
boundary condition: false

metaR r0559
reversible: true
is: SBO:0000176
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
fast: false

metaM 3thexddcoacrn e
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C23H41NO5 CHARGE: 0
type: Species
is: SBO:0000247
constant: false
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
is: HMDB02014

metaR r1651
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_56ee84af_097f_4ec9_a53d_4e35b582a70b
name: NME3
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is encoded by: hsa:4832
initial concentration: NaN
boundary condition: true
is: Q13232
initial amount: NaN

metaM acnam c
is: SBO:0000247
name: N-acetylneuraminate
initial amount: NaN
is: CHEBI:35418
has only substance units: false
type: Species
constant: false
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: HMDB00230
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_806796c0_5e9b_4d36_a50c_7e74f6243269
is encoded by: hsa:64077
is: SBO:0000252
name: LHPP
constant: false
initial amount: NaN
is: Q9H008
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN

metaM datp c
initial concentration: 1.0
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
name: dATP
initial amount: NaN
is: C00131
is: SBO:0000247
boundary condition: false
is: CHEBI:61404
constant: false
has only substance units: false
type: Species

metaR G14T17g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
product: MODEL1310110028#

metaM uri m
name: uridine
has only substance units: false
constant: false
is: HMDB00296
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species
is: SBO:0000247
is: CHEBI:16704
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM HC02216 c
constant: false
initial amount: NaN
is: CHEBI:28922
has only substance units: false
name: prostaglandin-f2beta
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: SBO:0000247
type: Species
boundary condition: false

metaM ksi pre10 g
is: CHEBI:58053
is: C00130
type: Species
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 10
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00175
notes: FORMULA: C129H209N9O98S2X CHARGE: -3

metaR r1654
is described by: ECO:0000000
product: MODEL1310110028#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110028#
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR TSTSTERONESULT
is version of: http://identifiers.org/ec-code/2.8.2.14
notes: GENE_ASSOCIATION: (6822.1) or (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
name: testosterone sulfotransferase
reversible: false
kinetic law: MODEL1310110028#

metaR PAFt
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
reversible: true
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaR FOLR2
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: folate reductase

metaR CEPTE
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.8.2
reactant: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (10390.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: ethanolamine phosphotransferase
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaM amp x
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00020
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: HMDB00045
is: CHEBI:456215
name: AMP

metaM g3m8masn r
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C88H147N2O70X CHARGE: 0
type: Species
is: C05873
has only substance units: false
boundary condition: false

metaM 3thexddcoacrn c
is: HMDB02014
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H41NO5 CHARGE: 0
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Species
has only substance units: false
is: SBO:0000247
constant: false

metaR FAOXTC101TC102m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

metaM 4ppcys m
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:59458
has only substance units: false
boundary condition: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
initial concentration: 1.0
constant: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: HMDB01117

metaR r1653
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction

metaR SUCCOAPET
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM hdca r
is: HMDB00220
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: C00249
name: Hexadecanoate (n-C16:0)
is: CHEBI:7896
constant: false
boundary condition: false
is: SBO:0000247

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM sphs1p c
is: SBO:0000247
initial amount: NaN
is: CHEBI:60119
constant: false
is: HMDB00277
type: Species
has only substance units: false
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false

metaR r1656
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_4772d3fa_3096_4025_aeb4_bb3ac3abc6ac
initial concentration: NaN
type: Species
is encoded by: hsa:8801
boundary condition: true
is: Q96I99
name: SUCLG2
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM ascb L c
initial amount: NaN
initial concentration: 1.0
is: HMDB00044
constant: false
is: CHEBI:38290
is: SBO:0000247
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
boundary condition: false
has only substance units: false
name: L-ascorbate

metaM hs deg15 l
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:16126
type: Species
name: heparan sulfate, degradation product 15
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
has only substance units: false

metaR FAOXC61C4x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaM gua e
has only substance units: false
is: CHEBI:16235
name: guanine
type: Species
is: HMDB00132
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242

metaR r1655
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
product: MODEL1310110028#
is: SBO:0000185
type: Reaction

metaR NACHEX12ly
reactant: MODEL1310110028#
is: SBO:0000176
reversible: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction

metaM o2s n
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
is: CHEBI:18421
is: HMDB02168
boundary condition: false
type: Species
name: superoxide

http://identifiers.org/biomodels.db/MODEL1310110028#_a1bb4cde_dcfb_4074_81dd_0ca86e4cdb70
is: Q92835
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:3635
boundary condition: true
name: INPP5D
initial amount: NaN

metaM tyr L m
is: HMDB00158
constant: false
name: L-tyrosine
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
has only substance units: false
initial amount: NaN
is: CHEBI:17895
is: SBO:0000247

metaM glyc m
has only substance units: false
is: CHEBI:17754
is: SBO:0000247
name: Glycerol
is: HMDB00131
boundary condition: false
constant: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
initial concentration: 1.0
is: C00116
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_0d88b7c1_534a_413f_8b33_6223f5327331
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:79966
type: Species
name: SCD5
has only substance units: false
is: Q86SK9

http://identifiers.org/biomodels.db/MODEL1310110028#_e67335c9_4038_481a_9de8_989c4ebe7ca2
is: Q6P9G0
initial concentration: NaN
name: CYB5D1
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:124637
is: SBO:0000252

metaM lcts e
name: Lactose
is: C00243
initial amount: NaN
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
boundary condition: false
constant: false
is: CHEBI:17716
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00186

metaM sphs1p e
initial amount: NaN
is: CHEBI:60119
constant: false
is: HMDB00277
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: sphingosine 1-phosphate(1-)
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_b6b013fa_8f09_4dc7_b53f_4a5cf803b9f1
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:10559
initial concentration: NaN
is: SBO:0000252
is: P78382
constant: false
name: SLC35A1
initial amount: NaN

metaR METtec
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
product: MODEL1310110028#
name: L-methionine transport via diffusion (extracellular to cytosol)
reversible: true
kinetic law: MODEL1310110028#

metaM guln r
constant: false
boundary condition: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
type: Species
is: HMDB03290
name: L-gulonate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:13115
initial amount: NaN

metaR RE2651R
reversible: true
type: Reaction
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is: SBO:0000176
name: RE2651

metaR r1658
reversible: true
modifier: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_261640c0_d5f3_4383_ad3f_a21e6158d17a
is encoded by: hsa:8693
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: Q8N4A0
name: GALNT4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_c172c9f1_8583_4c43_971a_80cdfa2cba74
has only substance units: false
initial amount: NaN
name: NMNAT2
boundary condition: true
is encoded by: hsa:23057
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR DHCR72r
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false
product: MODEL1310110028#
name: 7-dehydrocholesterol reductase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.21
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ

metaR FAOXC14C12m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaM ascb L e
is: HMDB00044
name: L-ascorbate
constant: false
initial concentration: 1.0
is: CHEBI:38290
is: SBO:0000247
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
boundary condition: false
initial amount: NaN
has only substance units: false

metaR AG13T10g
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110028#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176

metaM mev R x
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:36464
is: HMDB00227
initial amount: NaN
type: Species
name: (R)-mevalonate
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343

metaR GUACYC
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
is: SBO:0000176
product: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: guanylate cyclase
is version of: http://identifiers.org/ec-code/4.6.1.2
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000269

metaR TMDK1
fast: false
modifier: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.21
type: Reaction
kinetic law: MODEL1310110028#
reversible: false
name: thymidine kinase (ATP:thymidine)
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110028#

metaR SO4CLtex2
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
name: sulfate transport via chloride countertransport (2:1)
is: SBO:0000185
kinetic law: MODEL1310110028#
is described by: ECO:0000304

metaR BHBt
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate transport via H+ symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#
reversible: true

metaM hs deg13 l
is: HMDB01352
has only substance units: false
is: CHEBI:17180
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial amount: NaN
constant: false
name: heparan sulfate, degradation product 13
initial concentration: 1.0

metaR CO2tp
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110028#
name: CO2 peroxisomal transport
reversible: true
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_7743608e_5581_4c2a_8045_540684150b5e
is: SBO:0000252
name: PDE5A
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: O76074
constant: false
boundary condition: true
is encoded by: hsa:8654

http://identifiers.org/biomodels.db/MODEL1310110028#_997e893a_8f55_49e2_badc_a835ad7f7148
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:341947
has only substance units: false
boundary condition: true
constant: false
name: COX8C
is: Q7Z4L0
is: SBO:0000252

metaM glyc R m
name: D-glycerate
is: HMDB00139
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16659

http://identifiers.org/biomodels.db/MODEL1310110028#_913ceb57_a4eb_4c0a_9455_75c0000e8efc
is: SBO:0000252
is encoded by: hsa:374907
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: B3GNT8
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_29f35754_4080_40f6_a0ea_75d04de07bfa
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: NNT
type: Species
is: SBO:0000252
is encoded by: hsa:23530

http://identifiers.org/biomodels.db/MODEL1310110028#_34845850_bd2d_48d5_8fec_a1edaebf0e94
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:53354
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q8TE04
name: PANK1
boundary condition: true

metaR ETF
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
name: electron transfer flavoprotein
fast: false
is: SBO:0000176

metaR r1657
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
type: Reaction
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_4c576a95_971e_43ca_b947_cdfbdaf08b86
boundary condition: true
is encoded by: hsa:5832
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: ALDH18A1
type: Species
is: P54886

metaM mgacpail hs r
is: CHEBI:7896
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: HMDB00220
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: C00249
boundary condition: false

metaR DHORTS
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.1.3.2
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
reversible: true
is described by: ECO:0000269
fast: false
name: dihydroorotase
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_a3e4ba99_4db8_4042_8acb_dcd73ff0b4ad
has only substance units: false
initial amount: NaN
is encoded by: hsa:2639
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: GCDH

http://identifiers.org/biomodels.db/MODEL1310110028#_0692ae11_ebf5_41ba_893e_2e2c4a470bc7
has only substance units: false
is: P05166
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:5096
name: PCCB

http://identifiers.org/biomodels.db/MODEL1310110028#_ee4c817a_8dbb_46fa_8b80_e04f064b29ab
boundary condition: true
is: Q53Y83
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
name: GLA
has only substance units: false
is encoded by: hsa:2717

metaR BHBtm
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
type: Reaction
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport

metaR FACOAL1821
kinetic law: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
name: fatty-acid--CoA ligase
is described by: ECO:0000269
reactant: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110028#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C

metaM hdd2crn m
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
has only substance units: false
constant: false
type: Species
name: trans-Hexadec-2-enoyl carnitine
is: HMDB06317
initial concentration: 1.0

metaR GASNASE3ly
product: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.5.1.26
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
fast: false
type: Reaction
name: glycosylasparaginase, lysosomal
kinetic law: MODEL1310110028#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ef73f627_20a0_41c4_bf2b_d25915e836d4
constant: false
name: PLA2G2E
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:30814
is: Q9NZK7

metaR HIVCACBP
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
type: Reaction

metaM pdx5p c
has only substance units: false
initial concentration: 1.0
is: CHEBI:58589
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
is: SBO:0000247
name: Pyridoxine 5'-phosphate
is: HMDB01319
constant: false
type: Species
is: C00627
initial amount: NaN
boundary condition: false

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM 3octdeccrn e
is: SBO:0000247
initial concentration: 1.0
is: HMDB13336
initial amount: NaN
name: 3-hydroxyoctadecanoyl carnitine
type: Species
boundary condition: false
notes: FORMULA: C25H49NO5 CHARGE: 0
constant: false
has only substance units: false

metaR NACHEX1ly
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110028#
reversible: false
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110028#
type: Reaction

metaR FACOAL1822
is described by: ECO:0000269
reversible: true
name: fatty-acid--CoA ligase
is: SBO:0000176
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR CSNATer
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.7
is described by: ECO:0000254
product: MODEL1310110028#
type: Reaction
fast: false
is: SBO:0000176
name: carnitine O-acetyltransferase, endolasmic reticulum
notes: GENE_ASSOCIATION: (1384.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:11257506,PMID:3759988 NOTES:mm
modifier: MODEL1310110028#
reversible: true

metaR BCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy butyryl carnitine into extra cellular space
type: Reaction

metaR sink 5hpet LPAREN c RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: sink reaction for 5(S)-HPETE(1-)
type: Reaction

metaR r0456
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.32
product: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
kinetic law: MODEL1310110028#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
reversible: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
modifier: MODEL1310110028#
is: SBO:0000176

metaM CE5101 m
type: Species
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
initial concentration: 1.0
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57795
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_3cb8f54b_58e3_4770_b853_d812c03e3435
type: Species
has only substance units: false
name: ACO2
is encoded by: hsa:50
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q99798
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_be5bc9cc_2e36_4a58_8cdf_467c1b4d69ad
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8659
constant: false
initial amount: NaN
boundary condition: true
name: ALDH4A1
is: P30038
type: Species

metaM CE0713 m
name: 3-oxolinoleoyl-CoA
is: CHEBI:30623
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
type: Species
is: HMDB02329
constant: false

metaM 1pyr5c m
is: C03912
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:15893
constant: false
is: HMDB01301
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
name: 1-Pyrroline-5-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110028#_75883d20_2dfb_4396_875e_65a578b7a805
name: GUCY2C
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P25092
is encoded by: hsa:2984
boundary condition: true

metaR r0679
modifier: MODEL1310110028#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM 1pipdn2c x
initial concentration: 1.0
constant: false
is: HMDB01084
name: 1-piperideine-2-carboxylate
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16187
initial amount: NaN
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: SBO:0000247

metaM hs deg8 l
constant: false
initial concentration: 1.0
name: heparan sulfate, degradation product 8
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
type: Species
is: CHEBI:16126

metaM cspg b l
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:36005
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: HMDB02183

metaR r1756
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_de1db1a7_a24e_4f31_b0a2_483930dfe5b6
name: ESCO1
boundary condition: true
type: Species
is encoded by: hsa:114799
is: Q5FWF5
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_9e8687a0_4482_47ce_a06e_051133f3ea3d
initial concentration: NaN
name: OXCT2
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:64064
is: Q9BYC2

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
name: 4-nitrophenolate
constant: false
is: HMDB01232
is: CHEBI:57917
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ce60c506_d7f9_4f2f_9805_3d25f1fce424
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:349565
is: SBO:0000252
name: NMNAT3
type: Species
initial amount: NaN
is: Q96T66

metaM ksi pre17 g
is: CHEBI:28067
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
name: keratan sulfate I biosynthesis, precursor 17
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_d34eac52_a01f_4fd1_80c4_baa707478624
initial concentration: NaN
name: AK3
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:50808
is: E7ET30

metaR STRDNCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
name: transport into the mitochondria (carnitine)
type: Reaction
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

metaR r1831
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000

metaR ATPtm
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is: SBO:0000185
name: ADP/ATP transporter, mitochondrial
fast: false
product: MODEL1310110028#

metaM c3dc e
boundary condition: false
is: HMDB02095
notes: FORMULA: C10H16NO6 CHARGE: -1
initial concentration: 1.0
constant: false
has only substance units: false
name: malonyl carnitine
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_eb12bed5_d3de_464a_9a14_f0c7b8c1a660
initial amount: NaN
constant: false
is: SBO:0000252
is: Q6IBB3
initial concentration: NaN
type: Species
name: ATP5J2
has only substance units: false
is encoded by: hsa:9551
boundary condition: true

metaR r0801
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
reversible: true

metaR C4CRNCPT2
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of butyryl carnitine in the mitochondrial matrix for final hydrolysis
type: Reaction

metaR SERDGLYexR
modifier: MODEL1310110028#
reversible: true
is described by: ECO:0000304
is: SBO:0000185
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: D-Serine/Glycine reversible exchange
reactant: MODEL1310110028#

metaM mev R c
constant: false
is: CHEBI:36464
initial amount: NaN
boundary condition: false
is: HMDB00227
has only substance units: false
is: SBO:0000247
name: (R)-mevalonate
type: Species
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial concentration: 1.0

metaM HC02187 e
initial amount: NaN
is: CHEBI:28774
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
type: Species
name: reverse-triiodthyronine

http://identifiers.org/biomodels.db/MODEL1310110028#_6ad25500_2eb4_4afc_9358_a71fbd628ed6
is encoded by: hsa:53919
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: SLCO1C1
is: Q5JPA4
constant: false
initial concentration: NaN

metaR AG13T17g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
fast: false
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR IPDPtx
name: Isopentenyl diphosphate transport (peroxisome)
is described by: ECO:0000134
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:

metaM gal c
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0
name: D-Galactose
type: Species
is: SBO:0000247
constant: false
is: CHEBI:0
boundary condition: false
is: C00124
initial amount: NaN
is: HMDB00143
has only substance units: false

metaM tetdece1crn c
type: Species
is: HMDB02014
initial amount: NaN
notes: FORMULA: C21H39NO4 CHARGE: 0
name: tetradecenoyl carnitine
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR LCADi
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
name: lactaldehyde dehydrogenase
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
product: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_28becce1_8d76_4e46_b51c_0300af34fd9d
initial concentration: NaN
is: P26439
boundary condition: true
name: HSD3B2
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3284

http://identifiers.org/biomodels.db/MODEL1310110028#_7607f55c_18aa_40a5_b726_9d25298283ef
boundary condition: true
is: Q6IB54
is: SBO:0000252
name: ATP5J
has only substance units: false
is encoded by: hsa:522
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_1c1c5162_f99a_485f_b065_d212811ba4f2
name: _R51273_1_c
type: Species
is encoded by: hsa:R51273
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_f54e955a_08a6_4bfb_bef7_7fb9194149c4
initial concentration: NaN
is: B3KTV4
is encoded by: hsa:122622
initial amount: NaN
is: SBO:0000252
constant: false
name: ADSSL1
boundary condition: true
has only substance units: false
type: Species

metaR RE1233C
is described by: ECO:0000000
reactant: MODEL1310110028#
reversible: true
fast: false
kinetic law: MODEL1310110028#
name: RE1233
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_419bf4d6_0e90_4e48_b372_5044460a9b62
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:171425
initial concentration: NaN
initial amount: NaN
is: Q8N0X4
name: CLYBL

metaR CYTDtn
product: MODEL1310110028#
type: Reaction
name: cytidine transport in nucleus
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185

metaM c3dc c
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H16NO6 CHARGE: -1
is: HMDB02095
has only substance units: false
initial concentration: 1.0
name: malonyl carnitine
constant: false
type: Species

metaM clpn hs c
initial concentration: 1.0
initial amount: NaN
is: HMDB02704
has only substance units: false
notes: FORMULA: CHARGE: 0
is: SBO:0000247
name: clpn_hs[c]
is: CHEBI:21338
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_9d5f749a_70c9_4ded_bb5f_975f2e15fcee
is: SBO:0000297
type: Species
has only substance units: false
has part: P00338
has part: P07195
is encoded by: hsa:3945
constant: false
name: LDHA:LDHB
initial amount: NaN
boundary condition: true
is encoded by: hsa:3939
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_0b742b26_709a_4101_9629_08726ae82942
is encoded by: hsa:57665
boundary condition: true
initial concentration: NaN
name: RDH14
is: SBO:0000252
is: Q9HBH5
has only substance units: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_e00e1818_dafc_41ed_9746_553dbe1cfce1
initial concentration: NaN
is encoded by: hsa:5152
type: Species
has only substance units: false
name: PDE9A
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaM g1m8masn r
notes: FORMULA: C76H127N2O60X CHARGE: 0
type: Species
initial amount: NaN
constant: false
is: C05875
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR FUM
is: SBO:0000176
name: fumarase
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.2
reversible: true

metaM tetdece1crn e
boundary condition: false
notes: FORMULA: C21H39NO4 CHARGE: 0
constant: false
initial concentration: 1.0
name: tetradecenoyl carnitine
is: SBO:0000247
has only substance units: false
is: HMDB02014
initial amount: NaN
type: Species

metaM 3octdeccrn c
boundary condition: false
notes: FORMULA: C25H49NO5 CHARGE: 0
is: HMDB13336
name: 3-hydroxyoctadecanoyl carnitine
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_dc95ea03_b632_4ea7_8f65_355b74a64f84
is encoded by: hsa:377841
initial amount: NaN
is: Q5MY95
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: ENTPD8
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_388b08a2_577d_46c5_80c8_46743ef66098
name: SLC17A5
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:26503
boundary condition: true
is: SBO:0000252
is: Q9NRA2

metaM frdp c
name: Farnesyl diphosphate
initial concentration: 1.0
type: Species
is: C00448
is: HMDB00961
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
has only substance units: false
is: CHEBI:175763

metaM tym c
type: Species
boundary condition: false
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
initial amount: NaN
is: HMDB00306
name: tyraminium
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:327995
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_730e971a_cd7a_4157_a666_367efc1265da
has only substance units: false
name: EGFR
type: Species
constant: false
is: P00533
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1956

http://identifiers.org/biomodels.db/MODEL1310110028#_ef34a21b_1733_49dc_8c7b_152990319b9a
is encoded by: hsa:5295
name: PIK3CD:PIK3R1
constant: false
is: SBO:0000297
has part: E7EX19
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM CE2705 c
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: CHEBI:36781
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
name: quinonoid dihydrobiopterin

metaR r1428
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
type: Reaction
is: SBO:0000185
fast: false
name: Free diffusion
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ac8fd4b2_0f1e_47b9_a962_c71882796d7a
initial amount: NaN
is: P78540
type: Species
boundary condition: true
has only substance units: false
name: ARG2
is encoded by: hsa:384
initial concentration: NaN
constant: false
is: SBO:0000252

metaR INSTt4 2
fast: false
modifier: MODEL1310110028#
reversible: true
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
name: inositol transport via sodium symport
reactant: MODEL1310110028#
is described by: ECO:0000006

metaM spmd e
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01257
is: C00315
name: Spermidine
is: SBO:0000247
is: CHEBI:57834
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315

metaM cspg b e
is: HMDB00630
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
is: CHEBI:16040
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_e3880c02_686c_4430_b587_65cf4777018d
has only substance units: false
name: DGKZ
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8525
boundary condition: true
type: Species
is: B7Z2M9
constant: false

metaM decdicrn c
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB13325
name: decadienoyl carnitine
notes: FORMULA: C17H29NO4 CHARGE: 0
type: Species
has only substance units: false
boundary condition: false

metaM 1pyr5c c
initial amount: NaN
is: SBO:0000247
is: HMDB01301
is: C03912
type: Species
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
name: 1-Pyrroline-5-carboxylate
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaR DPHMBDCm
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
product: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
fast: false
type: Reaction

metaR IMPC
fast: false
modifier: MODEL1310110028#
reversible: true
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.1.2.3
name: IMP cyclohydrolase
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
kinetic law: MODEL1310110028#

metaR RE3001M
is version of: http://identifiers.org/ec-code/1.3.1.34
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: RE3001
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
reversible: true
type: Reaction

metaM zym int2 r
is: CHEBI:52386
is: SBO:0000247
initial concentration: 1.0
type: Species
name: zymosterol intermediate 2
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ca7d7eac_16e1_4c2c_b59e_5e5316405687
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:518
initial concentration: NaN
is: P48201
is: SBO:0000252
constant: false
boundary condition: true
name: ATP5G3

metaM ksi pre13 g
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 13
is: C00130
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00175
type: Species
is: CHEBI:58053

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR FAOXC4C4DCc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_119ea399_7269_464b_a0cf_40840cf3edc2
is encoded by: hsa:84693
initial amount: NaN
name: MCEE
is: Q96PE7
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaR Ser Thrtg
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
kinetic law: MODEL1310110028#
name: Ser/Thr transport (from golgi to lysosome)
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000269

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
initial concentration: 1.0
name: pentaglutamyl folate (DHF)
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB06487
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_a79d8c2a_0f74_4460_ae89_7378024fca32
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:3948
initial concentration: NaN
boundary condition: true
name: LDHC
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_dda6390b_1c0a_42df_ad2a_b155dbba384a
is: P24298
name: GPT
is encoded by: hsa:2875
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR S6TASE16ly
reversible: true
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110028#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_4b2d9265_6531_4c9b_b6ec_3de8277de9ce
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:622
name: BDH1

metaR RE1519M
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
product: MODEL1310110028#
fast: false
name: RE1519
type: Reaction
modifier: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaR r0365
modifier: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

metaR LEUtec
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
product: MODEL1310110028#
fast: false
name: L-leucine transport via diffusion (extracellular to cytosol)

metaM decdicrn e
initial amount: NaN
type: Species
is: HMDB13325
name: decadienoyl carnitine
notes: FORMULA: C17H29NO4 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_e74291f2_70dd_4b94_898d_42cad51ac70c
is: Q969N2
name: PIGT
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51604
constant: false
type: Species

metaR FACOAL180i
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C180 fatty acid activation
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_ec4cb399_52a2_4204_a8b1_4e9e898445fb
is encoded by: hsa:1329
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: COX5B
is: Q53YB7
constant: false
boundary condition: true
is: SBO:0000252
type: Species

metaR MACACI
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
name: maleylacetoacetate isomerase
type: Reaction
fast: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
reversible: false

metaM 5HPET c
boundary condition: false
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
initial concentration: 1.0
is: CHEBI:57450
is: HMDB01193
name: 5(S)-HPETE(1-)
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaR 3MOPte
is described by: ECO:0000134
reversible: true
name: Transport of 3-methyl-2-oxopentanoate
is: SBO:0000185
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaR r0451
reactant: MODEL1310110028#
type: Reaction
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_61f82878_ba2e_489b_8c6e_7de9f17e3445
is: SBO:0000252
constant: false
initial amount: NaN
is: O75387
initial concentration: NaN
is encoded by: hsa:8501
name: SLC43A1
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_ae6cb185_cfcc_4b46_8ae8_40cd5f89c517
is: SBO:0000252
type: Species
is encoded by: hsa:55907
is: Q8NFW8
initial amount: NaN
initial concentration: NaN
name: CMAS
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_f8c459df_c742_4342_b757_100916929e6e
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10606
name: PAICS
type: Species
boundary condition: true
initial concentration: NaN
is: P22234

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaM dmnoncoa x
is: HMDB11604
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
name: 4,8 dimethylnonanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110028#_d4510522_5dff_40bd_b303_21ba30b12b76
type: Species
has only substance units: false
initial concentration: NaN
name: ACP6
initial amount: NaN
boundary condition: true
is: Q9NPH0
is encoded by: hsa:51205
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_12c8cba4_34e1_41a5_992c_5376d22b3cf5
initial amount: NaN
constant: false
is encoded by: hsa:38
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: P24752
has only substance units: false
name: ACAT1

metaM CE5120 m
boundary condition: false
initial concentration: 1.0
name: trans-2-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
initial amount: NaN
is: CHEBI:57923
constant: false
type: Species
is: SBO:0000247
has only substance units: false

metaR PRPNCOAHYDm
is version of: http://identifiers.org/ec-code/4.2.1.18
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000134
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
name: Propenoyl-CoA hydrolase (m)
product: MODEL1310110028#

metaR ARGLYSex
name: Arginine/Lysine exchanger (Arg in)
fast: false
product: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
type: Reaction
reversible: false

metaM HC00695 m
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
initial concentration: 1.0
is: CHEBI:17432
constant: false
boundary condition: false
name: S-Succinyldihydrolipoamide

metaR GLYCLTtp
reversible: false
reactant: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
name: glycolate transport into peroxisome
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
fast: false

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaR r1649
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110028#
reversible: true
is: SBO:0000185
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110028#_cb5a1d2e_b9f7_4438_a742_7eb16962b292
has only substance units: false
boundary condition: true
type: Species
name: PANK1
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:53354
is: Q8TE04
initial concentration: NaN

metaM ppa e
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247
boundary condition: false
is: CHEBI:17272
constant: false
is: HMDB00237
initial concentration: 1.0
initial amount: NaN
type: Species
name: propionate
has only substance units: false

metaM lnlncacrn m
initial concentration: 1.0
name: alpha-linolenyl carnitine
type: Species
constant: false
is: HMDB06319
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
has only substance units: false
boundary condition: false

metaM gua c
name: Guanine
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: C00242
is: HMDB00132
is: CHEBI:16235
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_2a60f2f5_e23e_48bc_9762_d99b526ed6e2
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: O43865
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10768
name: AHCYL1
boundary condition: true

metaM 4hexdtricoa x
has only substance units: false
is: HMDB02288
name: 4,7,10-hexadecatrienoylcoa
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r1648
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_2488285b_3be9_4561_9774_165746648d5a
type: Species
is: P15309
has only substance units: false
name: ACPP
initial amount: NaN
is encoded by: hsa:55
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false

metaR PPDOy
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110028#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
product: MODEL1310110028#
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reactant: MODEL1310110028#

metaR RE0935E
reversible: true
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110028#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0935
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110028#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM xol7ah2al c
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial concentration: 1.0
type: Species
is: CHEBI:27428
boundary condition: false
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al

metaR r1989
kinetic law: MODEL1310110028#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110028#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
fast: false
is described by: ECO:0000000

metaR GGH 10FTHF6GLUe
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
modifier: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR r0360
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
fast: false
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.16

metaR DCSPTN1t
product: MODEL1310110028#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110028#
type: Reaction
reversible: true

metaR HTDCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaR C8DCc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_e1ab0070_0844_4f4f_8f08_8b5387f5c53b
initial amount: NaN
is encoded by: hsa:5152
is: SBO:0000252
name: PDE9A
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_61e99b9d_c7bf_4632_994a_6a599fa9a7fb
is: SBO:0000252
is encoded by: hsa:2639
is: Q92947
boundary condition: true
type: Species
initial amount: NaN
name: GCDH
constant: false
has only substance units: false
initial concentration: NaN

metaM thexddcoa m
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
constant: false
is: HMDB02288
name: trans7,10-hexadecadienoylcoa
is: SBO:0000247
boundary condition: false

metaR r0450
kinetic law: MODEL1310110028#
is: SBO:0000176
reversible: true
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reactant: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
product: MODEL1310110028#
fast: false

metaM elaidcrn c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Elaidic carnitine
is: HMDB06464
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
constant: false

metaR r1647
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_230ddaa0_f0a5_4953_bc0f_e3ce48622a79
is: O15056
is encoded by: hsa:8871
has only substance units: false
name: SYNJ2
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR DMHPTCRNCPT2
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
is: SBO:0000176
name: 2,6 dimethylheptanoly CoA carnitine transferase
reversible: true
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#

metaM ksi pre24 g
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
type: Species
boundary condition: false
is: CHEBI:58053
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 24
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00130
is: HMDB00175

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
product: MODEL1310110028#
name: KHte
is described by: ECO:0000134
kinetic law: MODEL1310110028#

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_0e26792a_3a7b_4df5_9b7f_523d3ebf308b
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2819
has only substance units: false
name: GPD1
is: F8W1L5
constant: false
type: Species
is: SBO:0000252

metaR r0149
type: Reaction
is: SBO:0000176
modifier: MODEL1310110028#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.39
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaR DOLGLCP Uter
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110028#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
fast: false
product: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#

metaR r1645
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110028#
product: MODEL1310110028#

metaR C6DCCACT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaR S6TASE2ly
kinetic law: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110028#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaM ditp c
is: CHEBI:61382
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB03537
boundary condition: false
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species
initial concentration: 1.0
has only substance units: false
name: dITP(4-)

metaM hs deg6 l
name: heparan sulfate, degradation product 6
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17180
is: SBO:0000247
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
is: HMDB01352
has only substance units: false
constant: false

metaM dcmp c
is: CHEBI:57566
is: C00239
initial amount: NaN
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
has only substance units: false
name: dCMP
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01202

metaR CHSTEROLt3
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
type: Reaction
kinetic law: MODEL1310110028#
name: cholesterol intracellular transport
fast: false

metaR GGLUCT
is: SBO:0000185
name: gamma-glutamylcyclotransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.2.4
reversible: false
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
type: Reaction

metaR NH4t3r
reversible: true
modifier: MODEL1310110028#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
name: ammonia transport via proton antiport
product: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#

metaR ASPTA
modifier: MODEL1310110028#
type: Reaction
name: aspartate transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110028#
fast: false
is: SBO:0000176

metaM dolp U r
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57683
name: dolichyl phosphate(2-)
initial concentration: 1.0
constant: false

metaR VD3
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000176
product: MODEL1310110028#
name: Vitamin D3 formation
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
fast: false
is described by: ECO:0000134

metaR r1646
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110028#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_0297d5e7_f4bf_499f_8d39_8aa31d9bd0c1
is: SBO:0000252
name: PROSC
initial amount: NaN
type: Species
has only substance units: false
is: O94903
is encoded by: hsa:11212
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c88903dd_046f_42b3_aade_7daab9ebfb14
name: GPX1
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2876

metaM dlnlcg c
constant: false
type: Species
is: CHEBI:53486
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
boundary condition: false
name: dihomo-gamma-linolenic acid (n-6)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB02925

metaR FAOXC123C102x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaR CHSTEROLt2
name: cholesterol intracellular transport
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110028#
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
fast: false
is described by: ECO:0000000

metaR HAtly
fast: false
name: hyaluronan transport, extracellular to lysosome
reactant: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR r1983
is described by: ECO:0000000
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_b6c23e92_9952_4af2_ab25_00e4223b097d
initial amount: NaN
is: H7C5B8
is: SBO:0000252
name: NDUFB2
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:4708

http://identifiers.org/biomodels.db/MODEL1310110028#_41721ebc_dc5e_4300_b123_4a94ff2fe157
constant: false
initial concentration: NaN
name: AMY2A
initial amount: NaN
boundary condition: true
type: Species
is: P04746
is encoded by: hsa:279
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_88fc33be_4eb1_4301_b036_f2a98e4263f1
is: SBO:0000297
type: Species
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
constant: false
is encoded by: hsa:509
has part: Q6I9V2
initial concentration: NaN
boundary condition: true
has part: P25705
has only substance units: false
is encoded by: hsa:498
initial amount: NaN

metaR C3DCe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR CO2t
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: CO2 transporter via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
reactant: MODEL1310110028#
fast: false

metaR PRO Dtde
is: SBO:0000185
reversible: true
product: MODEL1310110028#
is described by: ECO:0000134
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
fast: false
name: D-proline transport, extracellular

metaR r1643
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
product: MODEL1310110028#

metaR CHSTEROLt1
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110028#
fast: false
reversible: true
reactant: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
name: cholesterol intracellular transport
type: Reaction
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_cb658ec7_a74e_4ef3_8f4e_d7f3c1fb4ca7
initial amount: NaN
is encoded by: hsa:3030
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: HADHA
is: E9KL44
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_ba65f9bd_ca3a_4494_9af8_2651e9b20a54
is: Q9BY49
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PECR
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:55825
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_c18c7f0b_f811_43b6_84e6_1e426a1b2f09
boundary condition: true
has only substance units: false
constant: false
is: Q9HCC0
is encoded by: hsa:64087
initial concentration: NaN
initial amount: NaN
type: Species
name: MCCC2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_3e77b8b3_40b9_4233_963a_394e77bb5fdf
name: DGKB
initial amount: NaN
is: SBO:0000252
is: Q9Y6T7
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:1607
constant: false

metaM leuktrC4 e
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
name: leukotriene C4(2-)
has only substance units: false
type: Species
constant: false
is: CHEBI:57973
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01198
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_3127d02a_5f0d_413f_a9d7_bafd9d695bd7
type: Species
is: P22392
name: NME2
boundary condition: true
is encoded by: hsa:4831
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_89829943_fef5_4bfd_9941_58ff21193c90
constant: false
has only substance units: false
initial concentration: NaN
is: Q99519
initial amount: NaN
name: NEU1
is encoded by: hsa:4758
boundary condition: true
type: Species
is: SBO:0000252

metaR r1644
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DNDPt35m
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110028#
name: dGDP transport via dADP antiport
modifier: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
reversible: false
is described by: ECO:0000269

metaR ARGNm
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (384.1) SUBSYSTEM: Urea cycle EC Number: 3.5.3.1 Confidence Level: 4 AUTHORS: PMID:9144563 NOTES:SAB m
modifier: MODEL1310110028#
reversible: false
name: arginase (m)
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.3.1

metaM dlnlcg e
type: Species
is: CHEBI:53486
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0
is: HMDB02925
name: dihomo-gamma-linolenic acid (n-6)
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_3d9c9af5_b1be_4a20_aa9f_f32c6a308d13
name: CP
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1356
constant: false
is: P00450
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_4d837ad1_fc61_4292_a102_5f3782442c79
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:251
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: P10696
name: ALPPL2

http://identifiers.org/biomodels.db/MODEL1310110028#_9c693698_5d67_4e2e_8e80_aae6115f0a12
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6534
initial amount: NaN
is: Q99884
name: SLC6A7
has only substance units: false

metaR r1641
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185

metaR CYTK1n
is: SBO:0000176
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
is described by: ECO:0000269
fast: false
name: cytidylate kinase (CMP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM anth e
name: anthranilate
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: CHEBI:16567
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01123
boundary condition: false

metaR P4508B13r
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
name: sterol 12-alpha-hydroxylase (nadh)
is: SBO:0000176
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110028#
product: MODEL1310110028#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.14.13.95

metaR r0145
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is version of: http://identifiers.org/ec-code/1.8.3.1
product: MODEL1310110028#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
fast: false
reversible: true

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM c4dc e
is: HMDB02013
type: Species
initial amount: NaN
name: succinyl carnitine
is: http://identifiers.org/pubchem.compound/213144
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C11H18NO6 CHARGE: -1
is: C02862

metaR LNLCCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110028#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
modifier: MODEL1310110028#
reversible: false
is described by: ECO:0000269
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_f0b2e6c6_747d_4a9e_9ec4_eb2d1ca52524
is: Q6LEN5
type: Species
constant: false
name: CHAT
is encoded by: hsa:1103
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR 3AIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
reversible: false
name: 3-amino-isobutyrate transport
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM idp e
has only substance units: false
boundary condition: false
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
initial amount: NaN
name: IDP(3-)
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58280

metaM dcsptn1 c
is: http://identifiers.org/pubchem.compound/5282848
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
is: HMDB13123
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: docosa-4,7,10,13,16-pentaenoic acid
has only substance units: false

metaR r1642
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
modifier: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_c246cd38_d9bf_425d_8500_a4da5033e25d
is encoded by: hsa:4715
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: Q9Y6M9
name: NDUFB9
is: SBO:0000252
constant: false
initial amount: NaN

metaR DOLP Uter
is described by: ECO:0000000
product: MODEL1310110028#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
kinetic law: MODEL1310110028#
name: dolichol phosphate flippase (uterus)
reversible: false
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_f340fffe_5b1d_4347_ad6d_3b97558e1a14
name: SLC5A2
is: P31639
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:6524

metaM leuktrC4 c
initial amount: NaN
has only substance units: false
name: leukotriene C4(2-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57973
constant: false
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: HMDB01198

metaR 10FTHFtm
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
product: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
reversible: true
fast: false
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
kinetic law: MODEL1310110028#
type: Reaction

metaM ksi deg9 l
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 9
is: CHEBI:12936
is: HMDB00143
constant: false
has only substance units: false
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_75405d0b_0264_4393_b449_eee7cec74136
initial concentration: NaN
name: PANK2
has only substance units: false
boundary condition: true
is encoded by: hsa:80025
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q6P1K9

metaR MELATNOX
fast: false
reversible: false
name: Melatonin:NADP oxidoreductase
is version of: http://identifiers.org/ec-code/1.14.14.1
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (1557.1) or (1543.1) or (1545.1) or (1544.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15616152 NOTES:SAB made up name
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.48
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110028#
modifier: MODEL1310110028#

metaR GTHRDt
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
product: MODEL1310110028#
is: SBO:0000185
name: Glutathione transport into mitochondria
kinetic law: MODEL1310110028#
fast: false
type: Reaction

metaR G14T5g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110028#
is: SBO:0000176
fast: false
product: MODEL1310110028#

metaM triodthy e
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: HMDB00265
initial concentration: 1.0
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: CHEBI:18258
has only substance units: false
boundary condition: false

metaM xol7ah2al m
type: Species
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27428
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_e1219293_6253_4443_a7e8_59ca2bf0ec3b
name: HSD17B4
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3295
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: E9PB82
type: Species

metaM anth c
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01123
initial amount: NaN
is: CHEBI:16567
has only substance units: false
constant: false
name: anthranilate

metaM hexdiac c
is: SBO:0000247
type: Species
notes: FORMULA: C16H28O4 CHARGE: -2
boundary condition: false
is: C08260
is: HMDB00672
name: hexadecanediocacid
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false

metaM c4dc c
has only substance units: false
notes: FORMULA: C11H18NO6 CHARGE: -1
name: succinyl carnitine
constant: false
is: HMDB02013
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: C02862

metaM ddece1crn e
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: HMDB02250
is: SBO:0000247
has only substance units: false
notes: FORMULA: C19H35NO4 CHARGE: 0
name: dodecenoyl carnitine
boundary condition: false

metaR PAIL45P HStn
product: MODEL1310110028#
fast: false
type: Reaction
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is: SBO:0000185
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true

metaR r1980
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110028#
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM idp c
is: CHEBI:58280
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial concentration: 1.0
name: IDP(3-)
is: HMDB03335
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false

metaR r1429
is: SBO:0000185
fast: false
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reversible: true
name: Free diffusion
is described by: ECO:0000000
product: MODEL1310110028#

metaR ENGASE3ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false

metaM ksii core2 deg2 l
type: Species
name: keratan sulfate II (core 2-linked), degradation product 2
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
initial amount: NaN
is: HMDB00143
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:12936
initial concentration: 1.0

metaR UDPDOLPT U
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110028#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
type: Reaction
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.117
reversible: false
product: MODEL1310110028#

metaR FUMtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
type: Reaction
product: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
reversible: true
name: fumarate transport, mitochondrial
is described by: ECO:0000269

metaR r1640
fast: false
modifier: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_45d3580d_978a_4025_ac70_d66d2e3b33a5
name: EHHADH:ACAA1:HSD17B4:ACOX3
has only substance units: false
is encoded by: hsa:8310
boundary condition: true
has part: O15254
initial amount: NaN
type: Species
is: SBO:0000297
initial concentration: NaN
constant: false

metaR ABUTt2r
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
is described by: ECO:0000304
modifier: MODEL1310110028#
product: MODEL1310110028#
fast: false
name: 4-aminobutyrate reversible transport in via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r

metaR r0142
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
reversible: false
is: SBO:0000176
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reactant: MODEL1310110028#

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_771b87c0_a682_454f_9f0c_4a2e8e341917
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10991
initial concentration: NaN
is: Q99624
constant: false
initial amount: NaN
name: SLC38A3

metaR 3HKYNAKGAT
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
reversible: false
reactant: MODEL1310110028#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
product: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.6.1.7
kinetic law: MODEL1310110028#
type: Reaction

metaM dcsptn1 e
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: HMDB13123
name: docosa-4,7,10,13,16-pentaenoic acid
constant: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/5282848
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species

metaM bildglcur r
initial concentration: 1.0
is: CHEBI:58471
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
type: Species
constant: false
boundary condition: false
is: HMDB03325
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN

metaM methf c
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: CHEBI:57455
is: HMDB01354
initial concentration: 1.0
has only substance units: false
is: C00445
name: 5,10-Methenyltetrahydrofolate
initial amount: NaN
constant: false

metaR FAOXC5C5DCc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_3bc4e46c_8185_4247_9082_0d1ee41b3ebd
boundary condition: true
is encoded by: hsa:56953
initial concentration: NaN
has only substance units: false
type: Species
name: NT5M
is: Q9NPB1
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_88c9f972_937b_4b6f_aa53_d4ff4a5d5c22
constant: false
initial concentration: NaN
name: ACOT6
is: SBO:0000252
is: Q3I5F7
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:641372

http://identifiers.org/biomodels.db/MODEL1310110028#_ce8186ae_8e91_4703_abea_2bac9ce67c33
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:155184
initial concentration: NaN
boundary condition: true
constant: false
is: Q6PXP3
name: SLC2A7
type: Species

metaM hexdiac r
constant: false
has only substance units: false
is: SBO:0000247
is: C08260
boundary condition: false
notes: FORMULA: C16H28O4 CHARGE: -2
name: hexadecanediocacid
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00672

metaR r2308
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110028#
type: Reaction

metaR DRBK
reactant: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
name: Deoxyribokinase
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.15
product: MODEL1310110028#
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000304

metaR MTHFDm
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
reversible: true
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.3
product: MODEL1310110028#

metaM ddece1crn c
type: Species
notes: FORMULA: C19H35NO4 CHARGE: 0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB03712
has only substance units: false
initial concentration: 1.0
name: dodecenoyl carnitine
constant: false

metaM dd2coa x
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
boundary condition: false
has only substance units: false
initial amount: NaN
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
is: CHEBI:57330
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_553bb99f_ad30_4e0c_a979_32d1387581da
initial concentration: NaN
constant: false
is encoded by: hsa:7296
type: Species
is: Q16881
name: TXNRD1
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR C3STKR2r
product: MODEL1310110028#
reversible: false
name: C-3 sterol keto reductase (zymosterol)
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000134
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

metaR CORE2GTg
reversible: false
modifier: MODEL1310110028#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.102
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000

metaM elaidcrn m
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: HMDB06464
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
type: Species
name: Elaidic carnitine

http://identifiers.org/biomodels.db/MODEL1310110028#_5ee27e10_332e_494a_870d_0fc0ea875656
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1120
is: A0PJM6
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: CHKB

http://identifiers.org/biomodels.db/MODEL1310110028#_43787d9a_6527_49fd_aa27_487b34164766
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: ECHS1
boundary condition: true
has only substance units: false
is encoded by: hsa:1892
is: P30084
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_9fcb08b2_9e29_437a_85ae_361191c1fd0f
initial amount: NaN
type: Species
is: Q8N370
is encoded by: hsa:124935
has only substance units: false
initial concentration: NaN
name: SLC43A2
is: SBO:0000252
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_4605044a_bb60_41a4_b53f_89c16dfd9bcd
type: Species
name: SGSH
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6448
is: P51688

metaM ksi deg25 l
initial concentration: 1.0
is: CHEBI:57455
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
is: HMDB01354
name: keratan sulfate I, degradation product 25
type: Species

metaM 4hexdtricoa m
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB02288
name: 4,7,10-hexadecatrienoylcoa
constant: false
type: Species
boundary condition: false

metaM pail35p hs c
has only substance units: false
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57923

metaM homoval m
has only substance units: false
is: CHEBI:545959
is: SBO:0000247
name: Homovanillate
is: HMDB00118
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
initial amount: NaN

metaR r2309
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
kinetic law: MODEL1310110028#
fast: false
type: Reaction

metaR RE1796R
reversible: true
name: RE1796
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_2b6b783e_c659_499d_8483_979ef2f0b0a5
is encoded by: hsa:2348
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: FOLR1
boundary condition: true

metaR RBFK
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110028#
fast: false
name: riboflavin kinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.26
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#

metaM CE0785 m
is: SBO:0000247
is: CHEBI:57795
boundary condition: false
constant: false
name: cis,cis-myristo-5,8-dienoyl-CoA
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_4419efe3_80c9_477c_9713_f00e001d7e80
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: E9PNG0
type: Species
name: AMPD2
is encoded by: hsa:271
constant: false

metaM adrncoa c
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C16170
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/47205480
name: adrenyl coenzyme A
type: Species
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_61808c05_b9cc_41e0_b43d_d5d2d6eb5059
name: ATG9B
initial amount: NaN
type: Species
is: Q674R7
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:285973

http://identifiers.org/biomodels.db/MODEL1310110028#_d74f9e50_2541_476d_9c43_6c9876f179c1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q6GTM5
name: SC5DL
initial amount: NaN
is encoded by: hsa:6309
constant: false
type: Species

metaR FADH2tru
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110028#
name: FADH2 transporter, endoplasmic reticulum
product: MODEL1310110028#

metaM HC01712 m
is: SBO:0000247
name: S-Glutaryldihydrolipoamide
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
boundary condition: false
is: CHEBI:28391
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR r2052
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r1538
reversible: false
is: SBO:0000185
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000

metaM ksi pre2 g
is: HMDB00175
initial amount: NaN
constant: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: CHEBI:58053
is: C00130
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 2

metaR SMPD4
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
fast: false
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
name: sphingomyelinase

metaM Lkynr c
name: L-kynurenine
is: CHEBI:16946
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: HMDB00684

metaR 4ABUTtm
reversible: true
name: 4-aminobutanoate mitochondrial transport via diffusion
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a544059f_a7a2_43ef_8899_dd67d372f62e
is: P28330
initial amount: NaN
name: ACADL
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:33
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM ksii core2 pre8 g
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 8
notes: FORMULA: C75H121N6O56SX CHARGE: -2
type: Species
is: C00130

metaM lnlncacrn c
has only substance units: false
name: alpha-linolenyl carnitine
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
is: HMDB06319
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_270d9f43_c01c_47e6_934f_d8043e6931b2
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: B3GNT2
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10678

metaR EX c5dc
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_6467a269_f039_4f1b_ae51_6b89b3a3bb2a
is: P30613
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: PKLR
constant: false
is encoded by: hsa:5313
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_1363345a_7f28_4ced_b417_3a5fad96de19
is encoded by: hsa:5152
initial amount: NaN
boundary condition: true
has only substance units: false
name: PDE9A
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR NDPK3n
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
modifier: MODEL1310110028#
is: SBO:0000176
reversible: true

metaR r0671
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.22
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
is described by: ECO:0000000
modifier: MODEL1310110028#
is: SBO:0000176

metaM dhor S c
is: HMDB03349
initial amount: NaN
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
is: CHEBI:30864
name: (S)-dihydroorotate
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
has only substance units: false

metaM triodthy c
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00265
is: SBO:0000247
boundary condition: false
is: CHEBI:18258
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_0a9c9a33_af9d_49ec_b653_36c1ab38d1f2
type: Species
is encoded by: hsa:4247
name: MGAT2
initial concentration: NaN
is: Q10469
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM gal e
is: C00124
boundary condition: false
is: HMDB00143
initial amount: NaN
is: CHEBI:0
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0
has only substance units: false
type: Species
name: D-Galactose

metaR FAOXC180
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: Beta oxidation of long chain fatty acid
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaR ATPS4m
kinetic law: MODEL1310110028#
name: ATP synthase (four protons for one ATP)
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: false
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.6.4.6
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
type: Reaction
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.6.1.14
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.14

metaR RE3524R
reversible: true
name: RE3524
type: Reaction
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR r0033
product: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
modifier: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM 4mzym int2 r
type: Species
boundary condition: false
is: HMDB06838
constant: false
name: 4-Methylzymosterol intermediate 2
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_d67b20c5_d102_41c5_b72f_d9f3c4e9bd3d
constant: false
initial concentration: NaN
name: ADHFE1
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: Q8IWW8
is encoded by: hsa:137872
has only substance units: false

metaR SBTR
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
fast: false
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reactant: MODEL1310110028#
name: D-sorbitol reductase
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
modifier: MODEL1310110028#

metaR S6T2g
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110028#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110028#_f4369171_7cc7_4d9f_ac68_4c7d5d7ab687
has part: E5KS60
constant: false
name: SUCLG1:SUCLA2
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000297
is encoded by: hsa:8803

http://identifiers.org/biomodels.db/MODEL1310110028#_4221ba13_492e_40e7_b65f_e008fec15c88
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: HSD3B1
has only substance units: false
is: P14060
constant: false
type: Species
boundary condition: true
is encoded by: hsa:3283

metaM gal l
constant: false
is: SBO:0000247
is: HMDB00143
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
name: D-galactose
is: CHEBI:12936
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
initial concentration: 1.0

metaM ksii core4 deg1 l
is: HMDB00868
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: keratan sulfate II (core 4-linked), degradation product 1
initial concentration: 1.0
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110028#_123023d6_7b21_43de_9ca2_ed45db388eba
is encoded by: hsa:80270
is: Q9H2F3
name: HSD3B7
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaR r2055
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#

metaR AK2LGCHOLt
fast: false
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
type: Reaction
reversible: true

metaR RBK
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
name: ribokinase
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.15
reactant: MODEL1310110028#
is described by: ECO:0000304
reversible: false

metaR ACOAD10m
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reversible: false
product: MODEL1310110028#
fast: false

metaR r1754
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110028#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110028#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110028#
reversible: false

metaR COQ7m
is described by: ECO:0000269
type: Reaction
name: Ubiquinone biosynthesis COQ7
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
reversible: false
product: MODEL1310110028#

metaR H2ETer
reversible: false
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
name: H2 phosphoethanolaminyl transferase, endoplasmic reticulum
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000304
fast: false
type: Reaction

metaM hs deg16 l
name: heparan sulfate, degradation product 16
is: CHEBI:21338
initial concentration: 1.0
is: HMDB02704
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
boundary condition: false

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM sebcoa c
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: HMDB00651
initial amount: NaN
name: sebacoylcoa

metaM C05279 m
is: HMDB11123
is: SBO:0000247
name: trans,cis-Lauro-2,6-dienoyl-CoA
boundary condition: false
constant: false
is: CHEBI:28387
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
has only substance units: false
type: Species
initial concentration: 1.0

metaR EX ddecrn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaR DNDPt33m
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
product: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
is described by: ECO:0000269
reversible: false
type: Reaction
reactant: MODEL1310110028#
name: dGDP transport via dUDP antiport

metaR NACHEX22ly
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_957600e2_aab3_4e53_bb03_e54f9c41f8b6
has only substance units: false
name: ALDH9A1
is: P49189
initial amount: NaN
constant: false
is encoded by: hsa:223
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaR AG13T8g
kinetic law: MODEL1310110028#
reversible: false
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reactant: MODEL1310110028#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaM methf m
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
name: (6R)-5,10-methenyltetrahydrofolate
type: Species
initial amount: NaN
is: CHEBI:57455
initial concentration: 1.0
is: HMDB01354
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false

metaM ptdca c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
is: http://identifiers.org/pubchem.compound/22169126
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: pentadecanoate
is: HMDB00826

http://identifiers.org/biomodels.db/MODEL1310110028#_5a4c9cf9_e612_4274_b5bc_b37b5c94799f
is encoded by: hsa:203
constant: false
is: P00568
has only substance units: false
name: AK1
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_37be2911_36af_4c82_b563_0cf2d4b98fe2
initial amount: NaN
is: A0PJH2
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10476
boundary condition: true
has only substance units: false
name: ATP5H
type: Species

metaM leuktrA4 r
name: leukotriene A4(1-)
is: HMDB01337
is: SBO:0000247
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: CHEBI:57463
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6e22f2f1_35eb_4907_afad_b607943a6130
type: Species
is encoded by: hsa:3030
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: HADHA
initial amount: NaN
is: E9KL44
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_b98a83fa_21a5_4ad2_a09f_47d32a0af108
name: NDUFB10
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4716
is: A8K761

metaR PI45P3K
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110028#
reversible: false
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
fast: false

metaR RE1303C
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7937829 NOTES:
kinetic law: MODEL1310110028#
name: RE1303
reversible: false
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000

metaR URATEt
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
type: Reaction
name: urate export from cytosol
is described by: ECO:0000000
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_aaaf076b_8789_4533_85e3_4339ff53224d
constant: false
is: O60658
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PDE8A
type: Species
has only substance units: false
is encoded by: hsa:5151

metaM ksi deg14 l
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
name: keratan sulfate I, degradation product 14
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR CYSSNAT5tc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_178e0b1e_bf28_484b_8ede_b20f87d63bac
is: Q8IX04
has only substance units: false
boundary condition: true
initial amount: NaN
name: UEVLD
constant: false
is encoded by: hsa:55293
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_913b9dcb_e841_47c8_9b99_01c1e154949b
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: O00459
has only substance units: false
is encoded by: hsa:5296
name: PIK3R2

http://identifiers.org/biomodels.db/MODEL1310110028#_88f544d4_46a4_46cd_86b6_96fbdbc39b5b
name: GLRX2
is encoded by: hsa:51022
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN

metaM ptdca e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/22169126
boundary condition: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
name: pentadecanoate
is: HMDB00826
constant: false
has only substance units: false

metaR XOL27OHtm
name: 27 hydroxy cholesterol transport
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction

metaR FAOXC123C102m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR SRTNt6 2 r
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000269
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#

metaR r1745
is described by: ECO:0000000
type: Reaction
product: MODEL1310110028#
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: false
fast: false
modifier: MODEL1310110028#

metaR AG13T7g
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110028#
reactant: MODEL1310110028#

metaM cholcoads x
boundary condition: false
type: Species
is: HMDB06889
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
is: CHEBI:27505

metaM k e
boundary condition: false
name: potassium
initial amount: NaN
has only substance units: false
type: Species
is: C00238
is: HMDB00586
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: CHEBI:29103

metaM e4p c
is: SBO:0000247
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: CHEBI:16897
has only substance units: false
is: HMDB01321
name: D-Erythrose 4-phosphate
initial concentration: 1.0
is: C00279
boundary condition: false
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_85dd6e0f_6772_44fc_9146_ce33023d2704
is encoded by: hsa:5095
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: C9JPQ8
constant: false
name: PCCA
is: SBO:0000252

metaM HC00250 e
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919
boundary condition: false
name: hydrosulfide
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM adrncoa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
is: C16170
constant: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: adrenyl coenzyme A
initial concentration: 1.0

metaM dolp U c
boundary condition: false
type: Species
is: SBO:0000247
name: dolichyl phosphate(2-)
initial amount: NaN
constant: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
is: CHEBI:57683
has only substance units: false

metaM arachcrn c
is: HMDB06460
initial concentration: 1.0
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR FUMSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110028#
is described by: ECO:0000269
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
name: Fumarate:sulfate antiport, mitochondrial
reactant: MODEL1310110028#

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_dac19dbe_cb0b_4600_98b8_cff8624b28fd
constant: false
has only substance units: false
is encoded by: hsa:6120
is: SBO:0000252
is: Q96AT9
name: RPE
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c17ad6b5_e50d_4cb3_8376_1eb69df0db01
has only substance units: false
is: O95622
constant: false
name: ADCY5
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:111
type: Species

metaM galside hs c
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
type: Species
is: CHEBI:12947
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_bc4c4e9c_19fe_4983_bf44_2c40d64e88fe
is encoded by: hsa:83530
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _83530_1_c
type: Species
has only substance units: false
initial amount: NaN

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaM bildglcur e
is: SBO:0000247
is: CHEBI:58471
constant: false
initial amount: NaN
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
type: Species
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
has only substance units: false
initial concentration: 1.0

metaR FAOXC163C143m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_faa436a0_b5af_43e6_b802_4b8f9eccdb29
boundary condition: true
name: CPT2
is: SBO:0000252
initial amount: NaN
type: Species
is: P23786
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1376

metaR SEBCOAPET
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR CSPG Atly
reactant: MODEL1310110028#
reversible: false
type: Reaction
name: chondroitin sulfate A transport, extracellular to lysosome
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR GLYt7 311 r
reactant: MODEL1310110028#
fast: false
is: SBO:0000185
is described by: ECO:0000006
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: glycine reversible transport via sodium and chloride symport (3:1:1)
modifier: MODEL1310110028#

metaM amet r
has only substance units: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
is: CHEBI:15414
name: S-adenosyl-L-methionine
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false

metaR Htx
reversible: true
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
type: Reaction
reactant: MODEL1310110028#
fast: false
name: H transporter, peroxisome
product: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_a4a01d16_0d4a_4096_870e_2ac1588c1e6a
has part: A3KLL5
name: ATP1A3:ATP1B1
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:481
is encoded by: hsa:478
is: SBO:0000297
type: Species
initial amount: NaN
has part: B7Z2T0

http://identifiers.org/biomodels.db/MODEL1310110028#_e643d40d_0393_42ef_8313_c027800daf40
type: Species
initial amount: NaN
is encoded by: hsa:5151
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: PDE8A

metaR FAOXC204184m
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: false
fast: false
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

metaR r0051
modifier: MODEL1310110028#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.5
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
is described by: ECO:0000000

metaM stcoa c
initial concentration: 1.0
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: Stearoyl-CoA (n-C18:0CoA)
is: CHEBI:57394
is: C00412
is: HMDB01114
is: SBO:0000247
constant: false

metaM pi m
has only substance units: false
initial amount: NaN
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
constant: false
is: C00009
is: SBO:0000247
is: CHEBI:43474
name: hydrogenphosphate
initial concentration: 1.0
type: Species

metaR C161CRN2t
product: MODEL1310110028#
name: C161 transport into the mitochondria
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110028#_02a4bb19_b216_474f_815b_c6395a622baa
is encoded by: hsa:3712
is: SBO:0000252
boundary condition: true
name: IVD
is: B3KVI7
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaM pi n
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:43474
constant: false
name: hydrogenphosphate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110028#_c992c582_9052_4a93_b57b_b86ed4bfb7c0
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:115584
boundary condition: true
name: SLC5A11
is: SBO:0000252
is: Q8WWX8
has only substance units: false
initial amount: NaN

metaR P5CDm
product: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
is described by: ECO:0000269
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a7dbacbb_d970_4378_9aee_a6e2ac3c6b54
constant: false
type: Species
name: PIGW
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:284098
is: Q7Z7B1
is: SBO:0000252
boundary condition: true

metaM bildglcur c
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
constant: false
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_e4223044_18ad_4054_8101_e0d0fb0f135a
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:57026
name: PDXP
type: Species
is: Q96GD0

metaR RE2269E
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
name: RE2269
is version of: http://identifiers.org/ec-code/3.4.21.39
modifier: MODEL1310110028#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_79dc7e8a_f8fc_4951_9d44_5062aa7925e3
is: P49753
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:10965
name: ACOT2

metaM ctp e
is: HMDB00082
has only substance units: false
is: CHEBI:37563
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: CTP(4-)

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_474aa8e9_c9d3_4bdf_94b6_e00a426ed22d
initial concentration: NaN
is: Q96Q11
initial amount: NaN
is encoded by: hsa:51095
name: TRNT1
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true

metaM gpi sig r
is: CHEBI:58190
notes: FORMULA: Y CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00224
constant: false
type: Species
boundary condition: false
has only substance units: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)

http://identifiers.org/biomodels.db/MODEL1310110028#_c49ef619_c84e_440b_9d30_3d7715d0680c
type: Species
has only substance units: false
constant: false
is encoded by: hsa:2983
is: Q02153
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: GUCY1B3

http://identifiers.org/biomodels.db/MODEL1310110028#_31f7d024_1c17_4cdf_8275_9959ccd6799d
has only substance units: false
constant: false
type: Species
is encoded by: hsa:1327
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: COX4I1
is: SBO:0000252
is: P13073

metaR r0267
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.9
product: MODEL1310110028#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_4f598231_a008_4315_bc7c_c7c9f141fe80
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:9963
name: SLC23A1
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaM 3odcoa m
is: HMDB03939
constant: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: SBO:0000247
type: Species
boundary condition: false
name: 3-Oxodecanoyl-CoA
has only substance units: false
initial concentration: 1.0
is: CHEBI:28528
initial amount: NaN

metaM cs b deg1 l
is: SBO:0000247
has only substance units: false
is: HMDB01354
constant: false
boundary condition: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial amount: NaN
type: Species
is: CHEBI:57455

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ab1502db_eae3_43d9_a4c2_ae39b459c9ff
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
is: Q96CA6
name: ACAA1
has only substance units: false
is encoded by: hsa:30
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_0f41da4a_69b0_4eff_928e_a7c546d4796a
name: HAO2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:51179
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_9b012d47_adf1_4b74_807d_6737b5cf3371
is encoded by: hsa:6391
has only substance units: false
is encoded by: hsa:6390
is encoded by: hsa:6389
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has part: P21912
has part: Q99643
has part: O14521
constant: false
is: SBO:0000297
name: SDHA:SDHB:SDHC:SDHD
is encoded by: hsa:6392
has part: P31040

http://identifiers.org/biomodels.db/MODEL1310110028#_81d64bc4_b738_46d4_a000_cc99c21fafc0
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: _AA021081_1_r
constant: false
is encoded by: hsa:AA021081

http://identifiers.org/biomodels.db/MODEL1310110028#_a45681e2_c361_4ca4_8396_b6c29679f831
constant: false
is: SBO:0000252
has only substance units: false
name: UGP2
boundary condition: true
is encoded by: hsa:7360
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c54dd009_df0c_437b_9bb3_b1cd064f23bc
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:79017
initial concentration: NaN
has only substance units: false
is: B8ZZR8
name: GGCT

metaR r0268
is version of: http://identifiers.org/ec-code/3.1.3.2
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
product: MODEL1310110028#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.1

http://identifiers.org/biomodels.db/MODEL1310110028#_32690516_e4ee_49fb_abb2_53b8eaebee59
boundary condition: true
type: Species
name: PDE8B
constant: false
initial amount: NaN
is encoded by: hsa:8622
is: O95263
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_dfb6ef92_46a4_4d41_8ed3_c7271784f9ff
name: CHST5
is: Q9GZS9
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23563
initial amount: NaN
constant: false

metaM leuktrC4 r
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
is: SBO:0000247
is: HMDB01198
initial amount: NaN
name: leukotriene C4(2-)
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaR FAOXC201C181x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaM ctp c
type: Species
is: C00063
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
is: SBO:0000247
boundary condition: false
has only substance units: false
name: CTP
initial amount: NaN
initial concentration: 1.0
constant: false

metaR Htr
name: H transporter, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
type: Reaction
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaM ksii core2 deg9 l
is: HMDB00143
notes: FORMULA: C30H50N3O20X CHARGE: 0
is: CHEBI:12936
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 9
boundary condition: false
has only substance units: false

metaR NCKt
name: Na+/Ca2+-K+ exchange
product: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD

metaR r0055
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
is described by: ECO:0000000
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is version of: http://identifiers.org/ec-code/2.4.2.7

metaM prostgh2 c
is: HMDB01381
name: prostaglandin H2(1-)
type: Species
initial amount: NaN
constant: false
is: CHEBI:57405
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0

metaR ATP2ter
kinetic law: MODEL1310110028#
is: SBO:0000185
name: AMP/ATP transporter, endoplasmic reticulum
reversible: true
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
fast: false

metaR FAOXC16C14m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

metaR S6TASE15ly
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false

metaR TYROXDAc
modifier: MODEL1310110028#
reversible: false
product: MODEL1310110028#
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
fast: false
kinetic law: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110028#
is: SBO:0000176

metaR DOLPGT1 Uer
is described by: ECO:0000000
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.267
is: SBO:0000176
reversible: false
fast: false
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110028#

metaR CYSTA
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
reactant: MODEL1310110028#
name: cysteine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000304

metaM dsT antigen g
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01440
is: CHEBI:16497
notes: FORMULA: C36H56N3O26X CHARGE: -2
constant: false
name: disialyl-T antigen

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_48f1da72_c762_478c_a31b_ae405da8d71f
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NDUFB10
constant: false
is encoded by: hsa:4716
is: A8K761
initial amount: NaN
boundary condition: true

metaR ABTD
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
fast: false
kinetic law: MODEL1310110028#
reversible: true
is described by: ECO:0000000
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
name: L-arabinitol 4-dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110028#_bcff264d_8245_4f58_9eb5_a062e4ba821b
is encoded by: hsa:F23536
name: _F23536_1_m
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM pi r
is: CHEBI:43474
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
is: HMDB00973
boundary condition: false
is: C00009
name: hydrogenphosphate
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_57d30131_a02f_44a0_913e_92d623d3ba8f
name: CRAT
is encoded by: hsa:1384
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaM k c
has only substance units: false
constant: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
is: CHEBI:29103
initial amount: NaN
is: HMDB00586
boundary condition: false
type: Species
name: potassium
initial concentration: 1.0
is: SBO:0000247

metaM arachdcoa m
boundary condition: false
constant: false
name: arachidonoyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57368
initial concentration: 1.0
type: Species
is: HMDB06523
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

metaM stcoa m
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
is: CHEBI:57394
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM didp n
has only substance units: false
initial amount: NaN
is: CHEBI:28823
constant: false
boundary condition: false
is: HMDB03536
initial concentration: 1.0
name: dIDP
is: SBO:0000247
type: Species
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344

metaM core4 g
is: SBO:0000247
is: CHEBI:16478
type: Species
notes: FORMULA: C24H40N3O15X CHARGE: 0
initial amount: NaN
constant: false
name: Core 4
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR PNTK
is: SBO:0000176
modifier: MODEL1310110028#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.33
name: pantothenate kinase
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110028#

metaM frdp x
constant: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
is: HMDB00961
initial concentration: 1.0
name: farnesyl pyrophosphate(3-)
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:175763
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_0e5be7bc_ccfc_4f2b_9dfd_8f7294589c28
constant: false
boundary condition: true
is encoded by: hsa:5264
initial concentration: NaN
is: O14832
has only substance units: false
initial amount: NaN
type: Species
name: PHYH
is: SBO:0000252

metaM pi x
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00973
name: hydrogenphosphate
type: Species
is: SBO:0000247
is: CHEBI:43474
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_35fbdcc1_8e68_4f8b_b227_1c3ac861fbc7
is encoded by: hsa:6487
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: ST3GAL3
is: SBO:0000252
has only substance units: false

metaR r2199
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110028#
product: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
is: SBO:0000185

metaR ADPACTD
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaM prostgh2 e
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
is: HMDB01381
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57405
initial amount: NaN
constant: false
name: prostaglandin H2(1-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_f4a908c1_3af1_49c1_9bb7_336d92d6ea99
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:4882
name: NPR2

metaR GLYt4
reactant: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
reversible: false
name: glycine transport via sodium symport
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000269
product: MODEL1310110028#

metaM cysam c
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
has only substance units: false
type: Species
is: HMDB02991
boundary condition: false
initial amount: NaN
is: CHEBI:58029
is: SBO:0000247
initial concentration: 1.0
name: cysteaminium
constant: false

metaR ADNK1m
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110028#
name: adenosine kinase, mitochondrial
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is described by: ECO:0000000

metaR r1639
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110028#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_54626ab8_fe67_4556_88f1_f595fb727a9d
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10841
name: FTCD
boundary condition: true
is: O95954

metaR CSNATp
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
product: MODEL1310110028#
fast: false
type: Reaction
is: SBO:0000176
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
reversible: true
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_cc084571_7ff4_448a_bc7c_6e89b4f49fc1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1349
name: COX7B
is: P24311
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000252

metaM prpncoa m
constant: false
name: acryloyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: CHEBI:57367
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB02307

http://identifiers.org/biomodels.db/MODEL1310110028#_bc49138c_36e5_4593_9d38_45a949438c75
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: B4E0V8
initial concentration: NaN
is encoded by: hsa:3034
boundary condition: true
constant: false
name: HAL
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_01827654_bb09_4fea_aa3a_2b96c9633b23
boundary condition: true
is encoded by: hsa:3028
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: HSD17B10
has only substance units: false
type: Species
is: Q99714

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaR r0377
reactant: MODEL1310110028#
fast: false
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
product: MODEL1310110028#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is described by: ECO:0000000
kinetic law: MODEL1310110028#

metaR r2198
reactant: MODEL1310110028#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaM leuktrA4 e
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57463
is: HMDB01337
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
name: leukotriene A4(1-)

http://identifiers.org/biomodels.db/MODEL1310110028#_edb5e61d_ec2a_4f20_9945_8d5554244884
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is: Q99487
initial concentration: NaN
is encoded by: hsa:5051
type: Species
name: PAFAH2
initial amount: NaN

metaR GPIAT
reversible: false
reactant: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: glucosaminylphosphatidyl inositol acetyltransferase
fast: false
is described by: ECO:0000269
is: SBO:0000176
type: Reaction

metaR DOLPGT2 Uer
is described by: ECO:0000000
reversible: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.265
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
type: Reaction

metaM hs deg5 l
initial concentration: 1.0
name: heparan sulfate, degradation product 5
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17895
type: Species
constant: false
is: HMDB00158
has only substance units: false

metaR CSNATm
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
fast: false
kinetic law: MODEL1310110028#
name: carnitine O-aceyltransferase, mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
reversible: true

metaM c4dc x
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
name: succinyl carnitine
is: C02862
notes: FORMULA: C11H18NO6 CHARGE: -1
initial amount: NaN
boundary condition: false
is: HMDB02013

metaR PPCOACm
reversible: false
name: Propionyl-CoA carboxylase, mitochondrial
is version of: http://identifiers.org/ec-code/6.4.1.3
reactant: MODEL1310110028#
is described by: ECO:0000269
fast: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV
modifier: MODEL1310110028#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#

metaR r0899
reactant: MODEL1310110028#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110028#
name: Amino acid transporter ATB0+ Facilitated diffusion
product: MODEL1310110028#

metaR PVD3
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110028#
reversible: true
name: Previtamin D3 formation
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_3fe3db98_9240_49c8_82a4_30a13db7d16e
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:8790
is: SBO:0000252
name: FPGT
is: O14772
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_e2860944_968c_404d_9bc0_014c2e168f6b
has only substance units: false
initial concentration: NaN
is: P49327
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:2194
name: FASN
constant: false
type: Species

metaR NACHEX2ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
reversible: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal

metaM 4hbz m
name: 4-hydroxybenzoate
constant: false
initial amount: NaN
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00500
is: CHEBI:17879

metaR ARACHDCOAtx
product: MODEL1310110028#
name: fatty acid intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110028#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000185

metaM aps c
is: HMDB01003
constant: false
boundary condition: false
name: 5'-adenylyl sulfate(2-)
is: CHEBI:58243
initial amount: NaN
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM c8crn c
boundary condition: false
notes: FORMULA: C15H29NO4 CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
is: C02838
name: octanoyl carnitine
constant: false
has only substance units: false
is: HMDB00791
initial amount: NaN

metaM succ m
type: Species
is: CHEBI:30031
is: SBO:0000247
name: Succinate
constant: false
initial amount: NaN
is: HMDB00254
is: C00042
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042

metaR FACOAL181i
type: Reaction
is described by: ECO:0000269
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
name: C181 fatty acid activation

http://identifiers.org/biomodels.db/MODEL1310110028#_ebb0bf98_4d81_40a4_9d33_ac81768c8eb1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:3156
name: HMGCR
boundary condition: true
is: P04035
initial amount: NaN
type: Species

metaM gdp c
name: GDP
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
initial amount: NaN
is: C00035
boundary condition: false
is: CHEBI:58189
has only substance units: false
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_d870a4c8_2e5d_4c53_b92a_8dd839be159d
is encoded by: hsa:4846
initial amount: NaN
boundary condition: true
is: A0S0A7
name: NOS3
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_04a46f9e_fb66_4d76_b234_17eebd1ced9d
name: HADHA
is: SBO:0000252
is encoded by: hsa:3030
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: E9KL44
initial amount: NaN
boundary condition: true

metaM 4hpro LT c
is: HMDB00725
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial amount: NaN
is: CHEBI:18095
is: SBO:0000247
name: trans-4-hydroxy-L-proline
constant: false

metaR FACOAL1831
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
fast: false
reversible: true
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
kinetic law: MODEL1310110028#
name: fatty-acid--CoA ligase

metaM fmn c
is: CHEBI:58210
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01520
type: Species
name: FMN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
constant: false
is: C00061

http://identifiers.org/biomodels.db/MODEL1310110028#_648fb35f_b3ef_40dd_a003_26431df11674
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: NDUFS8
type: Species
constant: false
is encoded by: hsa:4728
is: SBO:0000252
is: O00217

metaM Ssq23epx r
is: HMDB01188
has only substance units: false
is: CHEBI:15441
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
name: (S)-2,3-epoxysqualene
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
initial concentration: 1.0

metaR C121CPT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaM arachdcoa c
name: arachidonoyl-CoA(4-)
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
is: CHEBI:57368
is: HMDB06523
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_53229af6_b415_4de4_9b3b_0f0ac0c96570
type: Species
name: CRAT
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1384
initial concentration: NaN
boundary condition: true
constant: false

metaM tmndnc c
is: HMDB01999
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: timnodonic acid C20:5, n-3
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/446284

metaR NDP10ex
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
kinetic law: MODEL1310110028#
name: nucleoside-diphosphatase (IDP), extracellular
modifier: MODEL1310110028#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
product: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#

metaR r2195
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110028#_e7d5da1b_c037_49cd_b18e_053a5f81d272
type: Species
initial amount: NaN
name: DGUOK
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1716
constant: false
is: SBO:0000252

metaM 3mox4hoxm c
is: CHEBI:27622
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00291
is: SBO:0000247
name: 3-Methoxy-4-hydroxymandelate
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584

metaR r1636
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true

metaM c8crn e
initial concentration: 1.0
constant: false
is: SBO:0000247
name: octanoyl carnitine
boundary condition: false
has only substance units: false
is: HMDB00791
initial amount: NaN
type: Species
is: C02838
notes: FORMULA: C15H29NO4 CHARGE: 0

metaM 4hbzcoa m
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
has only substance units: false
constant: false
initial amount: NaN
is: HMDB06467
type: Species
initial concentration: 1.0
name: 4-hydroxybenoyl-CoA
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_4a06ced5_1ff6_4052_bd32_e65eca152082
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: _H17063_1_m
boundary condition: true
constant: false
is encoded by: hsa:H17063

http://identifiers.org/biomodels.db/MODEL1310110028#_91605e71_9452_4b62_9066_c4c76a5ef83b
boundary condition: true
type: Species
is: SBO:0000252
name: _AI291895_1_c
is encoded by: hsa:AI291895
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaM 2octpencoa m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
constant: false
is: SBO:0000247
type: Species
name: 2,6,9,12,15-octadecapentenoylcoa
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_09b8f1f5_2709_457e_9ee9_f2959dcbc5bb
has part: P21953
name: DBT:DLD:BCKDHA:BCKDHB
is: SBO:0000297
is encoded by: hsa:594
initial amount: NaN
has part: B4DP47
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1629
type: Species
has part: P11182
constant: false
is encoded by: hsa:593
has only substance units: false

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR FACOAL1832
reversible: true
reactant: MODEL1310110028#
name: fatty-acid--CoA ligase
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C

metaM adrncoa x
initial concentration: 1.0
initial amount: NaN
name: adrenyl coenzyme A
has only substance units: false
is: C16170
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
constant: false
type: Species

metaR FAOXC18280m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110028#
fast: false
reversible: false
modifier: MODEL1310110028#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
is described by: ECO:0000000

metaR CAATPS
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
name: Ca ATPase
is: SBO:0000185
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.8
kinetic law: MODEL1310110028#

metaR GCC2am
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
name: glycine-cleavage complex (lipoamide), mitochondrial
modifier: MODEL1310110028#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_ee54fd1b_dd71_4d14_b88e_0c4e1cadd0b5
boundary condition: true
is encoded by: hsa:493
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: P23634
name: ATP2B4

metaM galside hs g
is: CHEBI:12947
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_fad41cf9_d1ec_43bb_9b94_220954b83136
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: PDE7A
is encoded by: hsa:5150
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR r1635
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
is: SBO:0000185

metaR COUCOAFm
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: 6.2.1.12 Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine. (EC 6.2.1.12) .
product: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
name: p-coumaroyl-CoA formation
reversible: false
kinetic law: MODEL1310110028#
type: Reaction

metaM amet m
is: CHEBI:15414
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247
has only substance units: false
is: HMDB01185
type: Species
name: S-Adenosyl-L-methionine
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00019

metaM HC00250 c
initial concentration: 1.0
name: hydrosulfide
is: CHEBI:29919
constant: false
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

metaR r1638
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaM fmn e
initial amount: NaN
is: CHEBI:58210
is: HMDB01520
constant: false
initial concentration: 1.0
is: C00061
boundary condition: false
notes: FORMULA: C17H19N4O9P CHARGE: -2
name: FMN
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_4ab335aa_e2bb_4a7d_8d77_046eb0c5c915
name: GAPDH
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:2597
is: E7EUT4
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_02a84a89_0ec4_4322_a80e_6d671524ad29
is: Q6IBE6
is encoded by: hsa:6484
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
name: ST3GAL4
constant: false

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
reactant: MODEL1310110028#
name: galactose-6-sulfate sulfatase, lysosomal
product: MODEL1310110028#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM ksii core4 deg2 l
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:12936
type: Species
initial concentration: 1.0
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: HMDB00143
has only substance units: false
name: keratan sulfate II (core 4-linked), degradation product 2
boundary condition: false

metaR r0463
fast: false
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#

metaR r0160
modifier: MODEL1310110028#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.3.2
reactant: MODEL1310110028#
product: MODEL1310110028#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: false

metaM stcrn c
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: stearoylcarnitine
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
type: Species
constant: false
initial concentration: 1.0
is: HMDB00848
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_1cefd827_59e2_4abf_8cee_7273e4314056
type: Species
is encoded by: hsa:23236
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PLCB1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_9cd29f10_4e9a_4a61_85a8_ca3e8717924f
name: SLC6A3
has only substance units: false
is encoded by: hsa:6531
constant: false
initial amount: NaN
is: Q01959
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r2197
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000185
reversible: true
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false

metaM dcholcoa c
has only substance units: false
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
is: HMDB06292
is: CHEBI:28701
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

metaM tmndnc e
is: HMDB01999
constant: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/446284
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
has only substance units: false
is: SBO:0000247
type: Species
name: timnodonic acid C20:5, n-3
initial concentration: 1.0

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaM idp n
initial concentration: 1.0
is: HMDB03335
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:58280
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
constant: false

metaR FAOXC181C161m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

metaR CSNATr
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
fast: false
type: Reaction
name: carnitine O-acetyltransferase
product: MODEL1310110028#
is: SBO:0000176
reversible: true

metaR r1637
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR ACHtn
is: SBO:0000185
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it

metaR RE2079R
is described by: ECO:0000000
name: RE2079
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#

metaR r0464
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_f8f2caf6_2a2f_4624_bf58_e8eec4a9a6e6
name: SLCO1A2
initial concentration: NaN
is encoded by: hsa:6579
type: Species
constant: false
initial amount: NaN
is: P46721
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_1c7afafe_5e30_498f_9ea7_2cc15c5ffe50
is: SBO:0000252
boundary condition: true
is: P47895
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:220
initial concentration: NaN
constant: false
name: ALDH1A3

metaM galside hs e
constant: false
has only substance units: false
is: CHEBI:12947
boundary condition: false
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ca64c986_4216_4860_a601_cf9625ecaf63
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:8897
boundary condition: true
name: MTMR3

metaM C05957 r
constant: false
initial amount: NaN
is: HMDB02710
type: Species
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
initial concentration: 1.0
name: Prostaglandin J2
has only substance units: false
boundary condition: false
is: CHEBI:27485

metaM leuktrA4 c
type: Species
is: CHEBI:57463
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
constant: false
boundary condition: false
is: HMDB01337
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: leukotriene A4(1-)

metaR r2196
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110028#
fast: false

metaR CSNAT3x
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#
name: carnitine O-aceyltransferase, peroxisomal
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:7654220,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110028#
is: SBO:0000176
type: Reaction

metaR r1631
is described by: ECO:0000000
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM lnlccoa m
is: SBO:0000247
is: HMDB01064
name: linoleic coenzyme A
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
boundary condition: false
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/5462164

metaM vacccrn c
initial concentration: 1.0
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB06351
is: SBO:0000247
type: Species
constant: false
name: Vaccenyl carnitine

metaR r0381
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#

metaR r2314
type: Reaction
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#

metaM ura e
constant: false
is: HMDB00300
boundary condition: false
is: SBO:0000247
has only substance units: false
name: uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
type: Species
initial concentration: 1.0
initial amount: NaN

metaM dece4coa x
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: HMDB02145
name: 4-decenoylcoa
constant: false
initial concentration: 1.0

metaM val L m
is: CHEBI:16414
initial concentration: 1.0
boundary condition: false
type: Species
name: L-valine
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: HMDB00883

metaR 34HPPte
is described by: ECO:0000134
reversible: true
is: SBO:0000185
name: Transport of 3-(4-hydroxyphenyl)pyruvate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_e9dc5873_afff_4ab7_ab9b_d3ad105e1aa7
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:117248
initial amount: NaN
name: GALNTL2
is: Q8N3T1
boundary condition: true

metaR r1632
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110028#

metaR r2046
reversible: false
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
type: Reaction

metaM tetdec2coa c
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: HMDB02014
initial concentration: 1.0
has only substance units: false
name: tetradecadienoylcoa
initial amount: NaN

metaM gln L e
initial amount: NaN
type: Species
is: CHEBI:18050
initial concentration: 1.0
is: HMDB00641
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false

metaR r2315
is: SBO:0000185
reactant: MODEL1310110028#
product: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_50f33c01_a965_4987_a5ba_13c0e66cfe76
constant: false
has only substance units: false
initial amount: NaN
is: Q16853
initial concentration: NaN
is encoded by: hsa:8639
is: SBO:0000252
type: Species
name: AOC3
boundary condition: true

metaM 4hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 4,7,10,13-hexadecatetraenoylcoa
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB02288
has only substance units: false

metaM 10fthf m
is: CHEBI:57454
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
type: Species
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
is: SBO:0000247
is: HMDB00972
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_312f1def_0697_41f6_93ba_2c3cb0f449f1
is encoded by: hsa:2109
constant: false
is: SBO:0000297
initial amount: NaN
name: ETFA:ETFB
has only substance units: false
type: Species
has part: P38117
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c6063839_68bf_4d7d_a643_1c8aa83afd8f
is: SBO:0000297
is encoded by: hsa:5096
has part: P05166
type: Species
initial amount: NaN
name: PCCA:PCCB
boundary condition: true
constant: false
initial concentration: NaN
has part: C9JPQ8
is encoded by: hsa:5095
has only substance units: false

metaR NACHEX20ly
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110028#
is: SBO:0000176
type: Reaction

metaR r1633
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#

metaM CE5117 m
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial concentration: 1.0
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
type: Species
has only substance units: false
is: CHEBI:57923
is: SBO:0000247

metaR r2312
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110028#
fast: false
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_d89f7577_459e_4c62_90fa_c407a2294c38
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: PANK2
is encoded by: hsa:80025
has only substance units: false
is: SBO:0000252

metaR IVCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaM ura c
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: HMDB00300
is: SBO:0000247
name: Uracil
is: C00106
type: Species
is: CHEBI:17568
initial concentration: 1.0
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106

http://identifiers.org/biomodels.db/MODEL1310110028#_93400a9a_a4a5_451b_ba6e_aaf51d64a59f
constant: false
boundary condition: true
is: Q8IYH3
name: HAS1
is: SBO:0000252
is encoded by: hsa:3036
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR NADH2 u10m
is version of: http://identifiers.org/ec-code/1.6.99.3
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
fast: false
is described by: ECO:0000134
reactant: MODEL1310110028#
product: MODEL1310110028#
name: NADH dehydrogenase, mitochondrial
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_b2b14c7c_ff4f_4b33_abac_584254ed32a7
initial concentration: NaN
is encoded by: hsa:51
is: Q15067
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ACOX1

metaR r0892
is: SBO:0000185
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000000
name: Facilitated diffusion
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.2.27
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
type: Reaction

metaM amet c
constant: false
is: SBO:0000247
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01185
initial amount: NaN
is: C00019
name: S-Adenosyl-L-methionine
type: Species
is: CHEBI:15414

metaR r2193
product: MODEL1310110028#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR 34DHPLACOX
type: Reaction
fast: false
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
product: MODEL1310110028#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110028#

metaR FAOXC15C13m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaR r1634
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction

metaR PRO1xm
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
name: proline oxidase (NAD), mitochondrial
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.5.99.8
reversible: false
product: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000254
kinetic law: MODEL1310110028#
type: Reaction

metaR 3SALATAim
is described by: ECO:0000304
type: Reaction
product: MODEL1310110028#
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
modifier: MODEL1310110028#

metaM gln L c
has only substance units: false
is: HMDB00641
boundary condition: false
initial amount: NaN
name: L-glutamine
initial concentration: 1.0
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
constant: false
type: Species

metaR r2313
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000

metaR MALSO3tm
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000269
product: MODEL1310110028#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Malate:sulfite antiport, mitochondrial
is: SBO:0000185
kinetic law: MODEL1310110028#

metaM sucsal m
is: HMDB01259
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: SBO:0000247
initial concentration: 1.0
name: Succinic semialdehyde
is: CHEBI:57706
constant: false
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

metaR HOCTDECCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaM HC01602 c
type: Species
constant: false
is: SBO:0000247
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00234
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_dae962a1_f790_4804_90af_919361af0df0
is encoded by: hsa:23057
boundary condition: true
constant: false
is: Q9BZQ4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: NMNAT2
has only substance units: false

metaM 4hpro LT e
initial amount: NaN
name: trans-4-hydroxy-L-proline
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
is: HMDB00725
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaM gdp e
boundary condition: false
is: CHEBI:58189
is: HMDB01201
name: GDP(3-)
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
is: SBO:0000247

metaR CYTDt
product: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
name: cytidine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110028#_37e5c0dc_cc4f_4b23_a694_a55ab4479a8d
initial amount: NaN
name: SLC23A2
boundary condition: true
type: Species
constant: false
is: Q9UGH3
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9962
has only substance units: false

metaM HC01397 x
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial concentration: 1.0
name: (S)-3-Hydroxyhexadecanoyl-CoA
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:27402
constant: false

metaR r2310
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110028#
fast: false

metaM c226crn m
name: cervonyl carnitine
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06510
is: http://identifiers.org/pubchem.compound/127055
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+

metaR CYTK2n
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110028#
reversible: true
is: SBO:0000176
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
name: cytidylate kinase (dCMP),nuclear

metaM creat c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: creatine
type: Species
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
has only substance units: false
constant: false
is: CHEBI:16919
initial amount: NaN

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR r0680
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.137
modifier: MODEL1310110028#
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

metaR EX tststerones LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: testosterone sulfate exchange
type: Reaction

metaR ARAB Lt
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
type: Reaction
name: L-arabinoase extracellular transport
kinetic law: MODEL1310110028#

metaR r1992
modifier: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_be66cb60_d48a_4fd5_8a38_85434a942719
constant: false
name: ST3GAL3
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:6487
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM hdd2crn c
is: HMDB06317
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: trans-Hexadec-2-enoyl carnitine

metaR r2311
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#

metaM spmd c
boundary condition: false
is: C00315
is: CHEBI:57834
initial amount: NaN
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
constant: false
name: Spermidine
has only substance units: false
type: Species
is: HMDB01257
initial concentration: 1.0
is: SBO:0000247

metaM stcrn m
initial concentration: 1.0
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: HMDB00848
initial amount: NaN
boundary condition: false
name: stearoylcarnitine

metaR r1418
kinetic law: MODEL1310110028#
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
reactant: MODEL1310110028#
type: Reaction

metaR S6TASE8ly
modifier: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110028#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
product: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reversible: true
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false

metaR G14T6g
reversible: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false
is: SBO:0000176
product: MODEL1310110028#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110028#_2d911712_f368_40e7_96b9_806daf367f4f
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AL525798
name: _AL525798_1_c

http://identifiers.org/biomodels.db/MODEL1310110028#_e11d13d8_6b1c_431e_acbb_1cd24260df17
is encoded by: hsa:AI440329
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: _AI440329_1_r
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_686f5f89_18b5_4907_b550_69fdbf09ea25
initial amount: NaN
is: O94777
name: DPM2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8818
constant: false
boundary condition: true
type: Species
has only substance units: false

metaM pi c
boundary condition: false
name: hydrogenphosphate
is: HMDB00973
is: C00009
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2
initial amount: NaN
is: CHEBI:43474

metaM phyt2ohcoa x
is: CHEBI:57334
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
is: SBO:0000247
is: HMDB01295
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: 2-hydroxyphytanoyl-CoA(4-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_3ce3d5a3_06fe_4adb_815e_20a61e558041
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: SLC27A1
is encoded by: hsa:376497

http://identifiers.org/biomodels.db/MODEL1310110028#_15518e5b_f533_4e26_9731_9a8bacef31f8
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27068
name: PPA2
is: SBO:0000252
is: Q9H2U2
has only substance units: false
constant: false
type: Species
boundary condition: true

metaR r1993
is described by: ECO:0000000
product: MODEL1310110028#
reversible: false
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110028#_8e26c59d_d3ab_4cb9_8a72_3204c648d67f
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: P10619
name: CTSA
is encoded by: hsa:5476
constant: false
initial concentration: NaN

metaM pristanal x
initial concentration: 1.0
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
has only substance units: false
is: CHEBI:49189
is: HMDB01958
boundary condition: false
name: pristanal
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

metaM bamppald c
is: HMDB01106
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: C05665
is: http://identifiers.org/pubchem.compound/7975
type: Species
name: beta-Aminopropion aldehyde
initial concentration: 1.0

metaM gdp g
is: HMDB01201
boundary condition: false
name: GDP(3-)
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189

metaM creat e
initial concentration: 1.0
boundary condition: false
name: creatine
type: Species
is: HMDB00064
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
has only substance units: false
initial amount: NaN
is: CHEBI:16919
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_5b293f5e_e50a_4f75_b09b_7ce4288fd4f7
initial concentration: NaN
name: PAPSS2
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9060
initial amount: NaN
is: O95340
type: Species
constant: false

metaM L2aadp m
constant: false
name: L-2-aminoadipate(1-)
type: Species
is: HMDB00510
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: CHEBI:58672
boundary condition: false

metaR DOLASNT Uer
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
type: Reaction
product: MODEL1310110028#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.119
fast: false

metaR CRNtx
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
name: carnitine transport peroxisome to mitochondria
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110028#
type: Reaction
fast: false

metaM f6p c
has only substance units: false
name: D-Fructose 6-phosphate
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3385
is: HMDB00124
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:57579
constant: false
initial amount: NaN
is: C00085

metaR r0157
reversible: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.2
reactant: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_37d7e9fb_9622_4d84_9e7d_f708d51c8ea7
is: SBO:0000252
constant: false
is encoded by: hsa:204
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
name: AK2
initial amount: NaN

metaR GACPAILter
name: glucosaminyl-acylphosphatidylinositol ER flippase
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_4d965e22_2c30_4138_aad8_ecca46acbb6e
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q7Z4W1
is encoded by: hsa:51181
name: DCXR
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_1eb25ee3_90d8_4576_a07d_45fa918c110b
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:4694
is: Q6IBB5
initial concentration: NaN
name: NDUFA1
constant: false
type: Species

metaM man1p c
name: D-Mannose 1-phosphate
is: CHEBI:35374
is: HMDB06330
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636

http://identifiers.org/biomodels.db/MODEL1310110028#_ec5719c7_3037_40a8_a7ec_d39bc04a0085
is encoded by: hsa:51268
initial concentration: NaN
is: Q9P0Z9
constant: false
has only substance units: false
name: PIPOX
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM ksii core2 pre9 g
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 9
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
is: CHEBI:28067
is: SBO:0000247
initial amount: NaN

metaR r1630
is described by: ECO:0000000
type: Reaction
product: MODEL1310110028#
is: SBO:0000185
reversible: true
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR M4CET3er
kinetic law: MODEL1310110028#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84720.2) and (5281.2) or (5281.1) and (84720.1) or (84720.1) and (5281.2) or (84720.2) and (5281.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15208306,PMID:15632136 NOTES:NCD
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.8.1
is: SBO:0000176
name: M4C phosphoethanolaminyl transferase, endoplasmic reticulum

metaR r0156
reversible: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110028#
product: MODEL1310110028#

metaM ksii core2 deg3 l
is: HMDB00143
boundary condition: false
constant: false
name: keratan sulfate II (core 2-linked), degradation product 3
initial amount: NaN
is: SBO:0000247
is: CHEBI:12936
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C58H94N5O46S2X CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110028#_635faa95_7bd9_4d88_8f8b_d3ab3bd92f95
is: Q8WUX1
is: SBO:0000252
is encoded by: hsa:92745
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: SLC38A5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_b42cdc6b_4a75_4f15_9459_5ab5154d32ce
initial concentration: NaN
initial amount: NaN
name: ALG2
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:85365
constant: false

metaM frdp r
is: C00448
boundary condition: false
is: HMDB00961
type: Species
name: Farnesyl diphosphate
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
initial amount: NaN
initial concentration: 1.0

metaM CE1926 e
constant: false
is: CHEBI:15748
is: HMDB00127
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
name: gama-carboxyethyl-hydroxychroman
is: SBO:0000247
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926

metaM retinal 11 cis c
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
is: CHEBI:16066
initial concentration: 1.0
name: 11-cis-retinal
is: SBO:0000247
constant: false
is: HMDB02152
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_19370b32_d1b9_46bc_8c53_4dbd10610e8d
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
name: PDE9A
is: SBO:0000252
is encoded by: hsa:5152

metaR GALASE5ly
product: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR 2OXOADPTm
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
product: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is: SBO:0000185
name: 2-oxoadipate shuttle (cytosol/mitochondria)
type: Reaction
kinetic law: MODEL1310110028#

metaM val L e
is: HMDB00883
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:16414
name: L-valine
initial amount: NaN
boundary condition: false

metaR MTHFCm
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
reversible: true
fast: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.3.4.3
type: Reaction
product: MODEL1310110028#

metaM hs deg20 l
name: heparan sulfate, degradation product 20
has only substance units: false
is: CHEBI:16126
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_f38e1310_b6bc_429a_bd12_6d74248c1ad4
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: PRPS2
has only substance units: false
initial concentration: NaN
constant: false
is: P11908
is encoded by: hsa:5634

http://identifiers.org/biomodels.db/MODEL1310110028#_b72c1b6f_7675_454c_945f_eb46504a0d3f
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:8527
constant: false
is: Q16760
has only substance units: false
name: DGKD
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_3f642840_f372_4431_8fac_26211a140fde
name: SLC25A5
constant: false
is: Q6NVC0
is encoded by: hsa:292
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaR 2HBt2
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reversible: true
name: 2-hydroxybutyrate cotransport with proton
is described by: ECO:0000269
fast: false
reactant: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#

metaM 10fthf e
constant: false
name: 10-formyltetrahydrofolate(2-)
initial amount: NaN
is: HMDB00972
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaR r0683
kinetic law: MODEL1310110028#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is: SBO:0000176
type: Reaction
modifier: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#

metaM gln L m
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:18050
type: Species
boundary condition: false
name: L-glutamine
is: HMDB00641

metaM dha e
is: HMDB01882
constant: false
boundary condition: false
type: Species
name: glycerone
is: CHEBI:16016
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184

metaM pi g
is: CHEBI:43474
type: Species
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
boundary condition: false
constant: false
name: hydrogenphosphate
is: HMDB00973
initial amount: NaN
initial concentration: 1.0

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR r1527
fast: false
reactant: MODEL1310110028#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.1
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
product: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_d65f8c12_b420_488b_ac86_f02d200173da
type: Species
is encoded by: hsa:7264
name: TSTA3
is: Q13630
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaR FAS160COA
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
name: fatty-acyl-CoA synthase (n-C16:0CoA)
is described by: ECO:0000269
type: Reaction
reversible: false
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR FAOXC141C141OHm
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_3ec48451_5ba4_43da_a14c_f1ba06f44031
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: AADAT
initial amount: NaN
constant: false
is encoded by: hsa:51166
initial concentration: NaN
is: Q4W5N8

http://identifiers.org/biomodels.db/MODEL1310110028#_014b1f06_e498_4dec_818b_d82efdc46c4d
is encoded by: hsa:4720
type: Species
is: B7Z792
is: SBO:0000252
name: NDUFS2
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaR AG13T16g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_011d6ca2_533c_4e93_a6ae_72f9951a0f7a
boundary condition: true
is: SBO:0000297
name: SLC7A8:SLC3A2
has part: Q86U05
is encoded by: hsa:23428
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reactant: MODEL1310110028#
is: SBO:0000176

metaM vacccrn m
initial concentration: 1.0
name: Vaccenyl carnitine
is: HMDB06351
constant: false
boundary condition: false
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h10-11,23H,5-9,12-22H2,1-4H3/b11-10+/t23-/m0/s1
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM val L c
name: L-valine
boundary condition: false
type: Species
has only substance units: false
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
is: HMDB00883
is: CHEBI:16414
initial amount: NaN
is: SBO:0000247

metaM CE5162 r
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
constant: false
name: trans,cis-2,9-octadecadienoyl-CoA
type: Species
initial amount: NaN
is: CHEBI:57923
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_0a7dfeb2_7cfa_4819_9623_62f06821ec95
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:314
boundary condition: true
type: Species
name: AOC2
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6bbc577e_bc3e_4a53_a4fe_daa00c1bc47f
type: Species
is: SBO:0000252
boundary condition: true
is: O60312
is encoded by: hsa:57194
initial concentration: NaN
name: ATP10A
has only substance units: false
constant: false
initial amount: NaN

metaM lnlccoa c
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
constant: false
initial concentration: 1.0
name: linoleic coenzyme A
is: HMDB01064
is: SBO:0000247

metaR LNELDCCPT1
fast: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
name: carnitine O-palmitoyltransferase
product: MODEL1310110028#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_c2df75b3_0644_4f11_bb16_f8eaee84e348
type: Species
name: _AI818585_1_c
is encoded by: hsa:AI818585
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN

metaM 10fthf c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: HMDB00972
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
boundary condition: false
is: C00234
is: CHEBI:57454

metaM dmnoncoa m
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
is: HMDB11604
name: 4,8 dimethylnonanoyl-CoA

metaR C226CPT1
modifier: MODEL1310110028#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
name: carnitine C22:6 transferase
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaM pi e
is: HMDB00973
is: CHEBI:43474
initial amount: NaN
type: Species
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00009
name: hydrogenphosphate
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_6761b18f_528c_4af2_b528_ed92956b4199
name: DGKD
initial concentration: NaN
is encoded by: hsa:8527
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ff74b3dd_fc4d_4fe7_98ac_132eb76095d9
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:122481
name: AK7
has only substance units: false
boundary condition: true
is: Q96M32
type: Species

metaM 4hpro LT m
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial amount: NaN
boundary condition: false
is: HMDB00725
name: trans-4-hydroxy-L-proline
is: CHEBI:18095

metaM ksi deg41 l
is: CHEBI:12936
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 41
initial concentration: 1.0
type: Species
notes: FORMULA: C34H58N2O26 CHARGE: 0
is: HMDB00143

http://identifiers.org/biomodels.db/MODEL1310110028#_99ce638c_b2e3_4249_8311_05d667b49a6e
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:522
type: Species
name: ATP5J
constant: false
initial concentration: NaN
initial amount: NaN

metaM cspg a l
is: CHEBI:36005
constant: false
is: HMDB02183
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan

metaR S6T3g
fast: false
modifier: MODEL1310110028#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.21
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.8.2.17

metaM pchol hs r
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
name: Phosphatidylcholine
boundary condition: false
is: CHEBI:16110

metaR C226CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
fast: false
type: Reaction
modifier: MODEL1310110028#
name: C226 transport into the mitochondria
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_6ed247b7_7822_49f5_b799_45dbf64aa2ca
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:215
initial concentration: NaN
name: ABCD1
is: P33897
boundary condition: true
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_a8515fa5_93cb_489e_8fa5_dcdf23c24299
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: AHCYL1
has only substance units: false
is encoded by: hsa:10768
constant: false
type: Species

metaM gdp m
is: C00035
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: HMDB01201
name: GDP
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR C101CPT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaM succ x
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
has only substance units: false
is: C00042
initial amount: NaN
boundary condition: false
name: Succinate
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00254
is: CHEBI:30031

metaR r0688
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110028#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:

metaR RE0691C
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: RE0691
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110028#
fast: false
is: SBO:0000176

metaM eicostetcrn c
is: CHEBI:57312
constant: false
boundary condition: false
name: Eicosatetranoyl carnitine
is: HMDB01356
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r2318
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110028#
reversible: true
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110028#_474bfde9_1a13_49bc_9766_cd6d1e710b68
name: TKTL1
is encoded by: hsa:8277
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: B7Z7I0
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_0107ac51_f62d_4850_9185_c4a5d16502a1
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:513
constant: false
has only substance units: false
name: ATP5D

metaM L2aadp c
initial amount: NaN
is: HMDB00510
is: SBO:0000247
constant: false
name: L-2-aminoadipate(1-)
boundary condition: false
is: CHEBI:58672
type: Species
initial concentration: 1.0
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false

metaM pi l
has only substance units: false
is: CHEBI:43474
is: SBO:0000247
constant: false
name: hydrogenphosphate
is: HMDB00973
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
type: Species
initial amount: NaN

metaM ddsmsterol r
has only substance units: false
boundary condition: false
name: 7-dehydrodesmosterol
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
initial amount: NaN
is: CHEBI:27910
is: HMDB03896
constant: false
type: Species

metaM 4hexdtetcoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
is: HMDB02288
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: 4,7,10,13-hexadecatetraenoylcoa
constant: false

metaM 4mzym int1 r
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB06927
name: 4-Methylzymosterol intermediate 1

http://identifiers.org/biomodels.db/MODEL1310110028#_6131cb3c_eb77_49b0_bad2_dae30db47be3
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI620219
type: Species
is: SBO:0000252
name: _AI620219_1_e

metaR ECOAH12m
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
product: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is described by: ECO:0000304
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is: SBO:0000176
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
fast: false

metaM cspg a e
is: CHEBI:16040
is: HMDB00630
constant: false
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
boundary condition: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_f9c21a02_353c_4867_b583_d74cc935eded
has only substance units: false
constant: false
is encoded by: hsa:23563
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CHST5

http://identifiers.org/biomodels.db/MODEL1310110028#_8973955c_e141_4592_8cdc_17cfa81a3a6a
has only substance units: false
type: Species
name: SLC13A5
initial concentration: NaN
is encoded by: hsa:284111
constant: false
is: SBO:0000252
initial amount: NaN
is: Q86YT5
boundary condition: true

metaM gdp n
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: CHEBI:58189
initial amount: NaN
name: GDP(3-)
is: HMDB01201
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR r2319
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

metaR MGSA
product: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: methylglyoxal synthase
reactant: MODEL1310110028#
fast: false
type: Reaction
is: SBO:0000176

metaR FAOXC163C142x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_582b9cb4_3ff6_4189_ad35_13bcb17d856b
is encoded by: hsa:4128
constant: false
initial amount: NaN
name: MAOA
is: SBO:0000252
is: Q53YE7
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM ksi pre23 g
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 23
initial amount: NaN
initial concentration: 1.0

metaM lac L x
initial concentration: 1.0
boundary condition: false
name: (S)-lactate
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00190
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false

metaM ppcoa x
is: CHEBI:57392
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
name: Propanoyl-CoA
is: SBO:0000247
is: HMDB01275
is: C00100
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR GTHRDtr
fast: false
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
name: glutathione transport via diffusion
reactant: MODEL1310110028#
reversible: true
product: MODEL1310110028#
is described by: ECO:0000000

metaR LNELDCCPT2
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

metaM HC00460 c
is: SBO:0000247
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false
name: 2,5-dihydroxybenzoate
constant: false
boundary condition: false
is: CHEBI:58044
type: Species
initial amount: NaN
initial concentration: 1.0

metaM ksii core4 pre3 g
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 3
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00130
constant: false
is: CHEBI:58053
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6e96c14b_325b_48fa_8fc9_2127c09a0930
boundary condition: true
name: PDE9A
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN

metaR URCN
reversible: false
reactant: MODEL1310110028#
fast: false
name: URCN
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.49
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110028#

metaM dcholcoa r
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
constant: false
is: SBO:0000247
is: HMDB06292
is: CHEBI:28701
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

metaM cdp n
initial concentration: 1.0
name: CDP(3-)
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01546
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: SBO:0000247
constant: false
is: CHEBI:58069

metaR NACHEX25ly
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
modifier: MODEL1310110028#

metaM CE2705 n
has only substance units: false
type: Species
is: CHEBI:15374
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
name: quinonoid dihydrobiopterin
is: HMDB02281
constant: false
boundary condition: false

metaR r2316
reversible: true
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110028#

metaM c226crn c
has only substance units: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: http://identifiers.org/pubchem.compound/127055
boundary condition: false
type: Species
constant: false
name: cervonyl carnitine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB06510

metaR C12DCACT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

metaM arachcrn m
boundary condition: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB06460

http://identifiers.org/biomodels.db/MODEL1310110028#_6b9fd84f_ca8e_44b6_8ce0_457d3531c396
is: SBO:0000252
is encoded by: hsa:1103
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: CHAT
is: P28329
initial concentration: NaN
type: Species

metaR NDPK4n
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
reversible: true
type: Reaction
modifier: MODEL1310110028#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
reactant: MODEL1310110028#
product: MODEL1310110028#

metaR S3TASE2ly
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_135ac882_3da2_4d5e_bb95_07f932c17611
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AI285872
type: Species
name: _AI285872_1_c

http://identifiers.org/biomodels.db/MODEL1310110028#_141e82b6_ebf9_48d4_85f2_558f83d7636d
is encoded by: hsa:11226
name: GALNT6
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q8NCL4
initial concentration: NaN
constant: false
boundary condition: true

metaR CYTDn
fast: false
name: cytidine deaminase, nuclear
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.5.4.5
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:
reversible: false
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction

metaR FAS80COA L
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
kinetic law: MODEL1310110028#
reversible: false
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
is: SBO:0000176

metaR r2317
kinetic law: MODEL1310110028#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110028#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaR MM6bg
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110028#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.113

http://identifiers.org/biomodels.db/MODEL1310110028#_6c4af012_c9cb_401e_b52c_f79295d83d46
boundary condition: true
is encoded by: hsa:2585
type: Species
has only substance units: false
initial amount: NaN
name: GALK2
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_75852f7c_73ca_4305_83f3_658352a734ea
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: OCRL
boundary condition: true
is encoded by: hsa:4952

metaM 25aics c
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: CHEBI:58443
boundary condition: false
is: C04823
constant: false
has only substance units: false
is: HMDB00797
type: Species
initial amount: NaN
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: SBO:0000247
initial concentration: 1.0

metaM retinal cis 13 r
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: HMDB06220
initial amount: NaN
name: 13-cis-retinal
has only substance units: false
is: CHEBI:45487

metaM dectricoa m
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false
initial amount: NaN
name: 2,4,7-decatrienoylcoa
constant: false
is: SBO:0000247

metaM hpdcacoa m
name: heptadecanoyl coa
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
is: SBO:0000247
is: HMDB06497
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaR r0580
is: SBO:0000176
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.99.7
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
reversible: true
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#

metaM xol7ah2 c
initial concentration: 1.0
is: CHEBI:28047
boundary condition: false
has only substance units: false
constant: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
initial amount: NaN
type: Species
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247

metaR HPDCACRNt
kinetic law: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
product: MODEL1310110028#
fast: false
name: heptadecanoate transport into the mitochondria

http://identifiers.org/biomodels.db/MODEL1310110028#_72b05359_e906_4a95_a9f8_77f276d754d4
initial amount: NaN
boundary condition: true
constant: false
name: QPRT
is: Q15274
is encoded by: hsa:23475
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR CYTK13n
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
name: cytidylate kinase (dCMP,dATP),nuclear
product: MODEL1310110028#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is described by: ECO:0000269

metaM imp c
is: C00130
initial amount: NaN
name: IMP
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
constant: false
is: CHEBI:58053
type: Species
is: HMDB00175
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a50e25d3_0e7f_4b99_9514_2a2b30567230
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57835
is: SBO:0000252
constant: false
name: SLC4A5
initial amount: NaN
type: Species
has only substance units: false

metaM hs deg3 l
boundary condition: false
has only substance units: false
name: heparan sulfate, degradation product 3
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16126
notes: FORMULA: C81H117N5O97S10 CHARGE: -12

metaM eicostetcrn m
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
constant: false
has only substance units: false
is: CHEBI:57312
initial amount: NaN
is: HMDB01356
is: SBO:0000247
name: Eicosatetranoyl carnitine
type: Species
boundary condition: false

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaR PHYCBOXL
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
reversible: false
name: L-Phenylalanine carboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
fast: false
modifier: MODEL1310110028#

metaR MI14P4P
reactant: MODEL1310110028#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
product: MODEL1310110028#
reversible: false
is described by: ECO:0000000
name: inositol-1,4-bisphosphate 4-phosphatase

metaM cgly c
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: HMDB00078
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:4047
name: L-cysteinylglycine

http://identifiers.org/biomodels.db/MODEL1310110028#_f1328535_5fb1_4a90_9e97_00976c31e21f
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:514
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: ATP5E

http://identifiers.org/biomodels.db/MODEL1310110028#_e818e498_fcca_47cd_8c39_7613077836c2
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AA526438_1_c
is encoded by: hsa:AA526438

http://identifiers.org/biomodels.db/MODEL1310110028#_94145e17_61f3_409b_865b_8ab7826c913a
is encoded by: hsa:51703
constant: false
is: SBO:0000252
name: ACSL5
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: Q9ULC5
initial concentration: NaN

metaM h c
is: C00080
name: proton
has only substance units: false
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:24636
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_46afdcb0_5af4_4a5f_93b7_9232cf3ad5a4
initial concentration: NaN
name: _AI539321_1_c
has only substance units: false
is encoded by: hsa:AI539321
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_3b5017d6_311c_485e_bbea_73f0acaa7066
is encoded by: hsa:3157
constant: false
is: Q01581
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: HMGCS1

metaM CE2434 m
is: CHEBI:57795
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
constant: false
type: Species
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR r1559
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
fast: false

metaM dutp c
is: CHEBI:17625
is: HMDB01191
boundary condition: false
name: dUTP
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00460
has only substance units: false
type: Species
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460

metaR ARACHCRNt
product: MODEL1310110028#
fast: false
reversible: false
type: Reaction
is: SBO:0000185
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM Ser Thr l
initial concentration: 1.0
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:58190
is: HMDB00224
notes: FORMULA: XH CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110028#_bc31b0fe_a6ad_4433_ac15_8f4d4177a30f
has only substance units: false
name: ENPP1
is: P22413
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:5167
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR FAOXC160
is described by: ECO:0000269
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
type: Reaction
modifier: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

http://identifiers.org/biomodels.db/MODEL1310110028#_99f06be2_f4e5_4125_8fb7_2fb869dfffec
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: A0PJJ9
constant: false
name: GGT7
initial concentration: NaN
is encoded by: hsa:2686

metaM dcacoa x
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
is: SBO:0000247
has only substance units: false
is: C05274
is: HMDB06404
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR RE0512M
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
type: Reaction
name: RE0512

metaR TYRTA
is: SBO:0000176
reversible: true
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
name: tyrosine transaminase
is described by: ECO:0000269
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110028#

metaM dcholcoa x
is: CHEBI:28701
type: Species
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB06292

http://identifiers.org/biomodels.db/MODEL1310110028#_c8092fc0_b2bd_4f3c_9473_49bfa9f7c9a3
name: PIP5K1A
type: Species
is encoded by: hsa:8394
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: Q99755

http://identifiers.org/biomodels.db/MODEL1310110028#_ad6abe4f_36e4_4b5f_93d9_c5821761ed3d
is encoded by: hsa:768
constant: false
initial amount: NaN
is: Q16790
boundary condition: true
name: CA9
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR ADSS
is: SBO:0000176
reversible: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
name: adenylosuccinate synthase
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reactant: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
fast: false

metaR LEUGLYHYc
reactant: MODEL1310110028#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
product: MODEL1310110028#
reversible: true
type: Reaction
fast: false
name: hydrolysis of leucylglycine
is: SBO:0000176
kinetic law: MODEL1310110028#

metaM imp e
has only substance units: false
is: SBO:0000247
name: IMP(2-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
constant: false
is: CHEBI:58053
is: HMDB00175
type: Species
initial amount: NaN

metaM c10crn c
initial amount: NaN
type: Species
notes: FORMULA: C17H33NO4 CHARGE: 0
initial concentration: 1.0
is: HMDB00651
is: SBO:0000247
boundary condition: false
name: decanoyl carnitine
has only substance units: false
constant: false

metaM glu5sa m
is: C01165
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
name: L-Glutamate 5-semialdehyde
boundary condition: false
is: CHEBI:17232
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: HMDB02104
type: Species

metaR PRAGSr
is: SBO:0000176
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.2
name: phosphoribosylglycinamide synthase
modifier: MODEL1310110028#
product: MODEL1310110028#

metaM HC02204 e
is: CHEBI:27624
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_95f9dfdf_335f_4cee_bef3_0fde46fc3576
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1119
boundary condition: true
name: CHKA
initial concentration: NaN
type: Species
constant: false

metaR PRO1x
fast: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
name: L-ProlineNAD+ 5-oxidoreductase
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
reversible: false
reactant: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110028#

metaM cgly e
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
is: HMDB00078
is: CHEBI:4047
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: L-cysteinylglycine
type: Species
has only substance units: false

metaR OCD11CRNCPT2
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_9e3cfefa_146b_435d_b283_02db25b339ec
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:43
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: ACHE

metaM h e
type: Species
initial amount: NaN
name: proton
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
initial concentration: 1.0
is: C00080
boundary condition: false
is: SBO:0000247

metaR r0584
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
type: Reaction
modifier: MODEL1310110028#
fast: false
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9

metaR FRDPtr
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport
product: MODEL1310110028#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_2f26e858_c73b_43e7_bde6_97194ee8c1c5
is: G5E960
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: PLCB3
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:5331

http://identifiers.org/biomodels.db/MODEL1310110028#_a333a387_72d1_4cb7_ab93_c522b60b74cb
initial amount: NaN
is encoded by: hsa:522
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ATP5J
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_8b9a3d39_f128_4d72_b30f_6075291ad569
boundary condition: true
name: ATP5F1
initial amount: NaN
is: SBO:0000252
type: Species
is: Q08ET0
is encoded by: hsa:515
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_997ca250_7c66_47af_a9a0_b8eaccad9082
type: Species
is: Q9NUB1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:84532
name: ACSS1

metaR GALNTg
is version of: http://identifiers.org/ec-code/2.4.1.41
type: Reaction
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#
name: GalNAc transferase, Golgi apparatus
modifier: MODEL1310110028#
product: MODEL1310110028#

metaM hmgcoa x
initial amount: NaN
is: CHEBI:15467
is: SBO:0000247
initial concentration: 1.0
is: HMDB01375
boundary condition: false
name: Hydroxymethylglutaryl-CoA
constant: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
type: Species
has only substance units: false

metaR MALSO4tm
type: Reaction
kinetic law: MODEL1310110028#
reversible: true
product: MODEL1310110028#
name: Malate:sulfate antiport, mitochondrial
fast: false
is described by: ECO:0000269
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110028#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_8011deba_fe54_47ea_882c_e9107787d235
name: SLC6A5
type: Species
is encoded by: hsa:9152
is: Q9Y345
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

metaM ddcacoa m
initial amount: NaN
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247
is: C01832
is: CHEBI:57375
constant: false
type: Species
is: HMDB03571
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
has only substance units: false
boundary condition: false

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_796e115a_7d46_4fed_baeb_500a9f2479be
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: O76082
name: SLC22A5
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6584

metaM h g
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: proton
type: Species
is: CHEBI:24636

metaM HC02204 c
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
type: Species
name: prostaglandin-b1
constant: false
is: CHEBI:27624
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM udp c
name: UDP
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: C00015
has only substance units: false
boundary condition: false
is: HMDB00295
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:58223
initial amount: NaN

metaR r1556
reversible: true
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#

metaM ksi deg36 l
is: CHEBI:12936
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB00143
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
is: SBO:0000247
name: keratan sulfate I, degradation product 36

http://identifiers.org/biomodels.db/MODEL1310110028#_a1de776c_5c43_4580_99ff_a9b61904a973
initial concentration: NaN
type: Species
is encoded by: hsa:54576
is: SBO:0000252
is: Q5DSZ6
has only substance units: false
constant: false
initial amount: NaN
name: UGT1A8
boundary condition: true

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR PROSTGD2t
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reversible: true
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110028#

metaR GSNt
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
fast: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
name: guanosine facilated transport in cytosol

metaM HC01397 m
is: CHEBI:27402
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
initial amount: NaN
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA

metaR SLCBK1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NCD
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.91
is: SBO:0000176
name: sphingolipid long chain base kinase (sphinganine)
reversible: false
fast: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#

metaR NACHEX24ly
reactant: MODEL1310110028#
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
modifier: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
fast: false

metaM udpglcur r
has only substance units: false
is: CHEBI:58052
type: Species
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
name: UDP-D-glucuronate
is: C00167
is: HMDB00935
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

metaM pram c
is: SBO:0000247
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: CHEBI:58681
initial concentration: 1.0
type: Species
has only substance units: false
name: 5-Phospho-beta-D-ribosylamine
constant: false
is: C03090
boundary condition: false
is: HMDB01128
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_1d8f8255_4f56_40f2_adea_45626ad6de5d
name: AK2
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:204
is: SBO:0000252
type: Species

metaM bilirub r
is: CHEBI:57977
is: HMDB00054
has only substance units: false
name: bilirubin(2-)
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486

http://identifiers.org/biomodels.db/MODEL1310110028#_c9d9d5cf_2abf_4751_809c_197291c02c24
type: Species
is encoded by: hsa:51
name: ACOX1
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: B4DK61
is: SBO:0000252

metaM ppcoa c
type: Species
initial amount: NaN
has only substance units: false
name: Propanoyl-CoA
is: HMDB01275
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
boundary condition: false
is: CHEBI:57392
is: SBO:0000247
initial concentration: 1.0
is: C00100

http://identifiers.org/biomodels.db/MODEL1310110028#_5f523dc4_28d7_4b19_adf0_a3861b8cf2b2
is encoded by: hsa:AA419122
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
name: _AA419122_1_c
type: Species

metaR q10h2tc
product: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000134
name: transport of ubiquinol into cytosol
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110028#

metaM fe3 e
type: Species
has only substance units: false
name: Fe3+
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
constant: false
is: CHEBI:29034
is: HMDB12943
boundary condition: false
initial amount: NaN

metaM sphgn c
is: HMDB00269
is: SBO:0000247
is: CHEBI:57817
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
name: sphinganine(1+)
constant: false
has only substance units: false

metaM ksi deg2 l
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
initial concentration: 1.0
boundary condition: false
is: CHEBI:30825
type: Species
is: SBO:0000247
is: HMDB00573
initial amount: NaN
has only substance units: false
name: keratan sulfate I, degradation product 2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ab3cb1ac_8024_4cd7_870f_39cbf657f014
is encoded by: hsa:1109
initial amount: NaN
has only substance units: false
is: P17516
constant: false
is: SBO:0000252
type: Species
name: AKR1C4
boundary condition: true
initial concentration: NaN

metaM 2ddecdicoa m
initial amount: NaN
is: C05279
initial concentration: 1.0
name: 2,6-dodecadienoylcoa
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB11123
type: Species
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4

metaR OMHPALTD
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM udp e
boundary condition: false
has only substance units: false
constant: false
is: HMDB00295
name: UDP(3-)
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:58223
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR FAOXC226205x
reversible: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR r1554
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR It
reactant: MODEL1310110028#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
product: MODEL1310110028#
type: Reaction
name: Iodide uniport
kinetic law: MODEL1310110028#

metaR r1553
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000000

metaR r1400
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
name: Active transport
reactant: MODEL1310110028#

metaR MI14Ptn
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
fast: false
reversible: true
product: MODEL1310110028#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_0a97c9df_f651_4a01_902b_952f351aded7
initial amount: NaN
is encoded by: hsa:84812
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: PLCD4
has only substance units: false
is: SBO:0000252
is: Q9BRC7

metaR PSFLIPm
product: MODEL1310110028#
name: phosphatidylserine flippase
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.6.3.1
reversible: false

metaR r1963
name: Y+LAT2 Utilized transport
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
reversible: false

metaR HEXDIACTD
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaM lac L e
constant: false
is: SBO:0000247
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
name: (S)-lactate
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16651
initial amount: NaN
type: Species

metaR r0475
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true

metaM HC01412 m
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
name: trans-tetradec-2-enoyl-CoA(4-)
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: SBO:0000247
type: Species
is: CHEBI:61405
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_92df4242_20ae_420d_9fb6_58861c038958
is: P06576
initial concentration: NaN
initial amount: NaN
type: Species
name: ATP5B
boundary condition: true
constant: false
is encoded by: hsa:506
has only substance units: false
is: SBO:0000252

metaR r1626
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ksi pre5 g
has only substance units: false
is: CHEBI:28067
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C101H164N7O75SX CHARGE: -2
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 5
is: SBO:0000247

metaR r1625
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is: SBO:0000185
reversible: true
product: MODEL1310110028#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#

metaR r1552
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ksii core4 pre7 g
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 7
is: C00130
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:58053
is: SBO:0000247
is: HMDB00175
initial amount: NaN
notes: FORMULA: C75H121N6O56SX CHARGE: -2

metaM udp g
has only substance units: false
name: UDP(3-)
is: HMDB00295
constant: false
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
boundary condition: false
is: CHEBI:58223
initial amount: NaN
initial concentration: 1.0

metaR r0173
is described by: ECO:0000000
modifier: MODEL1310110028#
reversible: true
type: Reaction
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.19
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
is: SBO:0000176

metaR EX 1glyc hs LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1 acyl phosphoglycerol exchange
type: Reaction

metaM ksi deg28 l
is: HMDB01354
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57455
name: keratan sulfate I, degradation product 28
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C104H170N7O85S3 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110028#_12345c80_9146_427d_b3b4_8b491943a512
has only substance units: false
boundary condition: true
initial amount: NaN
name: GUCY1B2
is: SBO:0000252
is encoded by: hsa:2974
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_3bef3769_2163_4d2b_8b91_3a0ad2807a2a
is: P06744
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2821
name: GPI

metaR C12DCTD
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaM csn c
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: SBO:0000247
initial amount: NaN
name: cytosine
constant: false
is: HMDB00630
has only substance units: false
is: CHEBI:16040

http://identifiers.org/biomodels.db/MODEL1310110028#_3724684f_5865_4007_b6f3_4be6d6e9f601
constant: false
is: Q9NQU1
name: SLC26A6
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:65010

http://identifiers.org/biomodels.db/MODEL1310110028#_60935217_a8e5_4bd6_bdc7_a225eef1e355
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q3KQV9
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:91373
name: UAP1L1

http://identifiers.org/biomodels.db/MODEL1310110028#_b4905556_8745_40ac_bae7_93df023bfcb0
is: Q546Y9
has only substance units: false
type: Species
initial amount: NaN
name: AICDA
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:57379

metaR r1624
reversible: true
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110028#
fast: false

metaR r1551
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0384
type: Reaction
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
reversible: false
fast: false

metaM lnlccrn m
name: Linoleyl carnitine
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB06469
is: SBO:0000247
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1

metaR r0170
modifier: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
product: MODEL1310110028#
reversible: true
type: Reaction
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_5d95406d_da03_4590_b824_fb85c527f365
has only substance units: false
is encoded by: hsa:2348
boundary condition: true
name: FOLR1
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaM h l
initial concentration: 1.0
has only substance units: false
name: proton
type: Species
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
is: CHEBI:24636
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_14a2941c_2dfc_45ab_8bb7_e2c76b3b790f
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P33261
name: CYP2C19
constant: false
type: Species
is encoded by: hsa:1557
is: SBO:0000252

metaM dece4coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
name: 4-decenoylcoa
boundary condition: false
initial concentration: 1.0
is: HMDB02145
type: Species
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_db8c1e68_f2c2_4cf9_a3f4_a23b740c6208
initial concentration: NaN
name: GGT1
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:2678
constant: false
is: P19440

metaR DURAD
name: dihydrouracil dehydrogenase (NADP)
reversible: true
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.2
kinetic law: MODEL1310110028#
is: SBO:0000176
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction

metaR r1623
fast: false
reactant: MODEL1310110028#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
is described by: ECO:0000000

metaR M1316Mg
fast: false
is: SBO:0000176
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.114
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
reversible: false
reactant: MODEL1310110028#
type: Reaction

metaM glc D r
is: SBO:0000247
name: D-glucose
initial amount: NaN
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:4167
is: HMDB00122
initial concentration: 1.0

metaR LCYSTAT
kinetic law: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM
product: MODEL1310110028#
name: L-Cysteate:2-oxoglutarate aminotransferase

metaM h m
is: CHEBI:24636
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
name: proton
is: C00080
constant: false
boundary condition: false
initial concentration: 1.0

metaR ADSK
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.25
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false
product: MODEL1310110028#
name: adenylyl-sulfate kinase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
type: Reaction

metaR r0587
reversible: true
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1

metaR r0474
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110028#
type: Reaction

metaR 34HPPOR
reversible: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
is version of: http://identifiers.org/ec-code/1.13.11.27
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_4b3c4f58_dcba_4d28_a3b3_308bf9f64ecc
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: PDE9A

metaR GALASE14ly
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110028#_de116637_5e24_4f90_b68a_d7871bcac07f
constant: false
initial amount: NaN
is encoded by: hsa:5152
name: PDE9A
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM csn e
is: HMDB00630
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
name: cytosine
is: CHEBI:16040
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false

metaM ddcacoa x
is: CHEBI:57375
has only substance units: false
type: Species
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
constant: false
is: C01832
initial concentration: 1.0
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247
is: HMDB03571
initial amount: NaN
boundary condition: false

metaM xol7ah2 m
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
constant: false
boundary condition: false
is: CHEBI:28047
is: SBO:0000247
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha-diol
initial concentration: 1.0
is: HMDB06893
has only substance units: false
type: Species

metaR PROSTGH2t
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: Prostaglandin H2 transport
fast: false

metaM h n
type: Species
boundary condition: false
has only substance units: false
name: proton
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:24636
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR 5ADTSTSTERONESULT
is described by: ECO:0000269
reactant: MODEL1310110028#
name: 5alpha-Dihydrotestosterone sulfotransferase
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.8.2.14
modifier: MODEL1310110028#
type: Reaction
reversible: false
fast: false
is: SBO:0000176

metaR NACHEX8ly
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
product: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
reversible: false
type: Reaction

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_fa8d76e8_5bee_49bc_b393_266fdcee4200
boundary condition: true
name: SLC13A3
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:64849
has only substance units: false
is: B4DIR8
type: Species

metaM udp l
is: SBO:0000247
is: CHEBI:58223
initial concentration: 1.0
has only substance units: false
is: HMDB00295
name: UDP(3-)
constant: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR PPA
fast: false
modifier: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#
is: SBO:0000176
reversible: false
product: MODEL1310110028#
name: inorganic diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.1
type: Reaction
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
kinetic law: MODEL1310110028#

metaM 34dhoxmand m
initial concentration: 1.0
is: CHEBI:27637
initial amount: NaN
name: 3,4-Dihydroxymandelate
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: HMDB01866
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580

metaR GLACter
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110028#
reversible: true
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110028#_1bcc468c_d695_4b88_ad33_85fe78663065
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AL038231
initial amount: NaN
name: _AL038231_1_c
initial concentration: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_04f0f8cc_21f5_4dd3_91e4_06d3b39865f9
type: Species
is: SBO:0000252
has only substance units: false
name: DPM2
initial amount: NaN
is encoded by: hsa:8818
boundary condition: true
constant: false
initial concentration: NaN

metaM c12dccoa c
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: HMDB00623
initial concentration: 1.0
is: SBO:0000247
name: dodecanedioylcoa
has only substance units: false

metaR S23Tg
fast: false
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000269
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
product: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.4

metaR HXPRT
type: Reaction
product: MODEL1310110028#
fast: false
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
reversible: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
modifier: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110028#

metaM Ser Thr g
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
type: Species
is: CHEBI:58336
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00645
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)

metaM ppcoa m
name: Propanoyl-CoA
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
is: C00100
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57392
has only substance units: false

metaR ARGtm
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
name: arginine mitochondrial transport via ornithine carrier
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_8abf0af9_0fc0_4279_84ae_9aeaed0d88b2
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: NDUFAB1
is: O14561
is encoded by: hsa:4706
is: SBO:0000252
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_edfe9cb3_a63c_4f83_9ec1_387ce1b3cae6
name: VNN1
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:8876
constant: false
is: SBO:0000252
initial amount: NaN
is: O95497
type: Species

metaM dc2coa m
boundary condition: false
name: trans-Dec-2-enoyl-CoA
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61406
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275

metaR THBPT4ACAMDASE
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
modifier: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
reversible: false

metaM c10crn e
has only substance units: false
name: decanoyl carnitine
is: HMDB00651
constant: false
notes: FORMULA: C17H33NO4 CHARGE: 0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR FAOXC142C122x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaM tststerone e
is: HMDB00234
is: CHEBI:17347
initial concentration: 1.0
initial amount: NaN
name: testosterone
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
boundary condition: false

metaR r0472
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
product: MODEL1310110028#
type: Reaction

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR r1629
reversible: true
product: MODEL1310110028#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_5c5e5d9d_a570_44a2_8863_d32f4b2ae5aa
name: CPT1B
is encoded by: hsa:1375
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: E9PCP2
type: Species
constant: false
boundary condition: true

metaR r1966
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a442efa9_ead1_4ff3_b819_c4162d819ec7
initial concentration: NaN
is: SBO:0000252
is: O95139
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4712
name: NDUFB6
has only substance units: false

metaR AMANK
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000269
name: N-acetyl-D-mannosamine kinase
reversible: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.59
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.14

metaM adn m
is: HMDB00050
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
constant: false
is: CHEBI:16335
has only substance units: false
name: adenosine
boundary condition: false

metaM CE4790 m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:57923
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
boundary condition: false
constant: false
is: SBO:0000247

metaM lac L c
is: HMDB00190
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651
is: SBO:0000247
name: (S)-lactate
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaR r0388
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
is: SBO:0000176
product: MODEL1310110028#
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
type: Reaction

metaR DHCR241r
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000134
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 24-dehydrocholesterol reductase [Precursor]
reversible: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
modifier: MODEL1310110028#

metaR S4TASE1ly
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction

metaR r1628
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_842548c9_4671_421d_8d84_7f3ecc521a23
constant: false
initial concentration: NaN
initial amount: NaN
name: TXNRD3
type: Species
is: Q86VQ6
boundary condition: true
is: SBO:0000252
is encoded by: hsa:114112
has only substance units: false

metaM s2l2fn2m2masn e
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00244
is: C00255
constant: false
is: CHEBI:3554
notes: FORMULA: C90H145N6O65X CHARGE: -2
name: PA6
initial concentration: 1.0
boundary condition: false

metaM udp m
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false
is: HMDB00295
name: UDP(3-)
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:58223
initial amount: NaN
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_eada3aa3_85b9_487a_8268_57d4107ea11e
type: Species
initial amount: NaN
is: Q9NQR4
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:56954
has only substance units: false
name: NIT2

http://identifiers.org/biomodels.db/MODEL1310110028#_4687613e_ff94_4ee1_83fb_eeb6ee05c567
is: SBO:0000252
is encoded by: hsa:56474
is: Q9NRF8
name: CTPS2
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaM ksi deg17 l
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: HMDB00143
name: keratan sulfate I, degradation product 17
initial concentration: 1.0
is: CHEBI:12936
constant: false
initial amount: NaN

metaR CITRtm
modifier: MODEL1310110028#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
name: citrulline mitochondrial transport via proton antiport
kinetic law: MODEL1310110028#
is described by: ECO:0000269

metaR r0389
reversible: true
is: SBO:0000176
product: MODEL1310110028#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaR r0236
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reversible: true
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
is: SBO:0000176
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.6
type: Reaction
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR S6T18g
is version of: http://identifiers.org/ec-code/2.8.2.21
type: Reaction
kinetic law: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
reactant: MODEL1310110028#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17
is: SBO:0000176
product: MODEL1310110028#

metaR r1401
type: Reaction
product: MODEL1310110028#
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.2.1.35
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.3
is version of: http://identifiers.org/ec-code/2.3.1.51
reversible: false
is version of: http://identifiers.org/ec-code/2.7.10.1
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
modifier: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#

metaR RE1903R
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: RE1903
is: SBO:0000176
reversible: true

metaM n2m2nm l
initial concentration: 1.0
type: Species
is: CHEBI:30825
has only substance units: false
initial amount: NaN
is: HMDB00573
is: SBO:0000247
name: n2m2nmasn (w/o peptide linkage)
notes: FORMULA: C58H97N5O41 CHARGE: 0
constant: false
boundary condition: false

metaR r1627
reversible: true
is: SBO:0000185
product: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_e06d65cd_32f5_4f42_b360_2e887c0fe6b4
name: SLC2A3
is: SBO:0000252
constant: false
is: P11169
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:6515
boundary condition: true

metaM tststerone c
is: CHEBI:17347
is: HMDB00234
initial concentration: 1.0
has only substance units: false
name: testosterone
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
boundary condition: false

metaM dadp n
is: SBO:0000247
is: HMDB01508
is: CHEBI:57667
constant: false
boundary condition: false
type: Species
has only substance units: false
name: dADP(3-)
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
initial concentration: 1.0

metaR DASCBR
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
modifier: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.4.1
reactant: MODEL1310110028#
reversible: false
type: Reaction
product: MODEL1310110028#
name: dehydroascorbate reductase

metaR LGNCt
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
reversible: true
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#

metaR UMPK6n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dCTP),nuclear
is described by: ECO:0000269
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction

metaM udp n
name: UDP(3-)
constant: false
has only substance units: false
type: Species
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC226205m
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: false
name: Beta oxidation of long chain fatty acid
fast: false
type: Reaction
reactant: MODEL1310110028#

metaM ins e
has only substance units: false
is: HMDB00195
initial amount: NaN
is: CHEBI:17596
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
boundary condition: false
constant: false
is: C00294
initial concentration: 1.0
name: Inosine

metaR UMPK7n
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
name: UMP kinase (dGTP),nuclear
fast: false

metaR r0480
reversible: true
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction

metaM dttp e
name: dTTP(4-)
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: HMDB01342
is: CHEBI:37568
has only substance units: false
initial concentration: 1.0

metaM adn c
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
is: CHEBI:16335
initial amount: NaN
name: Adenosine
initial concentration: 1.0
is: HMDB00050
is: C00212
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_12f9e342_2658_4695_a13a_47784c99f283
is: SBO:0000297
is encoded by: hsa:522
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false
boundary condition: true
has part: Q6IB54
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_ae3ee84f_a929_4512_a992_d9f0e7c851f9
type: Species
initial concentration: NaN
is encoded by: hsa:516
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
boundary condition: true
has part: Q6FIH7
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110028#_cfde9fe1_bd13_44cc_b03b_33f90a0a162c
is encoded by: hsa:4701
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: NDUFA7
is: Q6FG42
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6b260cd7_ab0d_4b07_9321_681337808f6e
name: GGT1
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:2678
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR C162ACBP
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM cholcoar x
initial concentration: 1.0
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
type: Species
boundary condition: false
is: HMDB02178
initial amount: NaN
is: CHEBI:58677
has only substance units: false
is: SBO:0000247
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
constant: false

metaM hxcoa x
is: HMDB00705
constant: false
boundary condition: false
type: Species
has only substance units: false
name: Hexanoyl-CoA (n-C6:0CoA)
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM hyptaur c
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
name: Hypotaurine
is: SBO:0000247
initial amount: NaN
is: CHEBI:16668
is: HMDB00965

http://identifiers.org/biomodels.db/MODEL1310110028#_32759d7b_1230_4c77_a4d3_75187dc8f525
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:89874
initial amount: NaN
initial concentration: NaN
type: Species
name: SLC25A21
is: SBO:0000252
is: G3V4L5

http://identifiers.org/biomodels.db/MODEL1310110028#_eb0a7106_3425_4e10_8fe6_7b7aed94fdf3
is encoded by: hsa:10846
constant: false
is: SBO:0000252
is: Q9Y233
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: PDE10A
type: Species
has only substance units: false

metaM 3mob c
type: Species
constant: false
is: CHEBI:11851
initial concentration: 1.0
is: HMDB00019
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
initial amount: NaN
name: 3-methyl-2-oxobutanoate

metaR URAt
fast: false
is described by: ECO:0000269
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
name: uracil transport via facilated diffusion
product: MODEL1310110028#
modifier: MODEL1310110028#

metaR IDOAASE2ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: alpha-L-iduronidase, lysosomal
product: MODEL1310110028#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
kinetic law: MODEL1310110028#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_2c331939_3562_42e5_b46e_46d06665ca35
is: SBO:0000252
is encoded by: hsa:6319
name: SCD
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: O00767

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110028#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110028#
is described by: ECO:0000000
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR PDE1
is version of: http://identifiers.org/ec-code/3.1.4.17
is version of: http://identifiers.org/ec-code/3.1.4.35
kinetic law: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
name: 3',5'-cyclic-nucleotide phosphodiesterase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaM h r
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
boundary condition: false
name: proton
type: Species
initial concentration: 1.0
is: C00080
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_67fdebc4_8677_4fa8_b58a_b344bc749c7e
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9NY65
name: EHHADH
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1962
has only substance units: false

metaR r0390
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
fast: false
is: SBO:0000176
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_db2c969d_f5e0_4ad0_9d04_1e9e7b6984fd
boundary condition: true
is encoded by: hsa:W74642
name: _W74642_1_c
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false

metaM bilirub c
constant: false
is: CHEBI:57977
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
initial amount: NaN
name: bilirubin(2-)
has only substance units: false
type: Species
is: HMDB00054

metaR C3STDH1r
is version of: http://identifiers.org/ec-code/1.1.1.170
name: C-3 sterol dehydrogenase (4-methylzymosterol)
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ

metaM ksi pre28 g
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 28
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247
type: Species
is: C00130
initial amount: NaN
constant: false
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_3488bc5a_c74c_4d9e_868e_73fd31a6a89e
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:518
is: SBO:0000252
boundary condition: true
constant: false
name: ATP5G3
initial amount: NaN

metaR URIt5le
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

metaM ins c
is: SBO:0000247
is: C00294
has only substance units: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
constant: false
initial amount: NaN
is: CHEBI:17596
is: HMDB00195
initial concentration: 1.0
name: Inosine
type: Species
boundary condition: false

metaM hs deg19 l
constant: false
initial concentration: 1.0
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: HMDB01352
is: CHEBI:17180
initial amount: NaN
name: heparan sulfate, degradation product 19
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_b9dcae7b_7503_4a65_a9b8_5cee8517cd3f
is: P47895
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: ALDH1A3
is encoded by: hsa:220

http://identifiers.org/biomodels.db/MODEL1310110028#_6fcea644_5585_4d92_9c63_59e63554c7ac
initial concentration: NaN
is: Q9HAB8
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:79717
name: PPCS
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a29decef_52b0_4b9d_8cbc_f7c3a0f3e0e0
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:AA278423
initial amount: NaN
is: SBO:0000252
name: _AA278423_1_m
has only substance units: false
constant: false

metaR LNLCt
type: Reaction
reactant: MODEL1310110028#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
name: Linoleic acid (n-C18:2) transport in via diffusion
is described by: ECO:0000000

metaR PDE4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.17
kinetic law: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.4.35
name: 3',5'-cyclic-nucleotide phosphodiesterase
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110028#_4edc847f_8f32_4706_9281_b68848d03f8a
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: PPAP2C
boundary condition: true
is encoded by: hsa:8612
has only substance units: false
constant: false
is: E9PAY8

metaR FAOXTC102C101m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_587f958c_9f61_421c_b32a_ef461ce0afcb
type: Species
initial amount: NaN
name: _AA532636_1_m
constant: false
is encoded by: hsa:AA532636
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_eca48c07_f919_4788_be67_8b4366b71c5c
is: SBO:0000252
name: NDUFB4
type: Species
is: O95168
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:4710

metaM 3mob e
is: CHEBI:11851
boundary condition: false
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
is: HMDB00019
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
constant: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_da784e17_0337_4090_9e47_d85ca5def71a
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:AI971036
initial amount: NaN
has only substance units: false
name: _AI971036_1_x
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_3d696382_fe27_4721_b91d_5e8e07068c62
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:124454
name: EARS2
is: Q5JPH6
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_94269af6_cd9d_42cb_831c_791408f7c32e
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is: Q53FV7
is encoded by: hsa:1375
initial amount: NaN
name: CPT1B
type: Species

metaM cmp n
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
constant: false
name: CMP(2-)
has only substance units: false
is: HMDB00095
type: Species

metaR HEXCCOAtx
fast: false
name: fatty acid intracellular transport
type: Reaction
product: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110028#

metaR FAOXC205C185m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaM 5adtststerone e
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:16330
is: HMDB02961
has only substance units: false
constant: false
initial concentration: 1.0

metaM bilirub e
boundary condition: false
constant: false
type: Species
is: HMDB00054
has only substance units: false
name: bilirubin(2-)
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: CHEBI:57977
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_85538aed_8c89_4606_b92b_2bbbd1a7bda9
initial concentration: NaN
constant: false
is: Q9NUD9
type: Species
boundary condition: true
name: PIGV
is encoded by: hsa:55650
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR NDPK1n
fast: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110028#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear

metaR r0166
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
reversible: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
is described by: ECO:0000000

metaM dttp c
initial concentration: 1.0
is: HMDB01342
is: CHEBI:37568
is: SBO:0000247
initial amount: NaN
is: C00459
has only substance units: false
type: Species
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP
boundary condition: false

metaM dnad c
is: HMDB01179
initial concentration: 1.0
is: SBO:0000247
is: C00857
is: CHEBI:18304
constant: false
type: Species
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
has only substance units: false
name: Deamino-NAD+
boundary condition: false
initial amount: NaN

metaM co2 m
constant: false
is: HMDB01967
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: CO2
initial amount: NaN
is: CHEBI:16526
is: C00011
initial concentration: 1.0

metaM 3dodtricoa x
type: Species
has only substance units: false
is: HMDB11123
name: 3,6,9-dodecatrienoylcoa
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: C05279
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false

metaR r2038
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
product: MODEL1310110028#
modifier: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_7bf0835b_695e_4b02_be8b_f1e207cd6400
initial amount: NaN
name: DGKH
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:160851
is: A8K0I1
is: SBO:0000252

metaM cs b deg2 l
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57455
initial concentration: 1.0
constant: false
is: HMDB01354
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
notes: FORMULA: C37H54NO41S3 CHARGE: -5
boundary condition: false

metaM icit c
constant: false
initial concentration: 1.0
is: HMDB00193
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:16087
name: Isocitrate
is: C00311

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

metaR CATm
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110028#
reversible: false
name: catalase
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.6
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 4 AUTHORS: PMID:1657986,PMID:3755525 NOTES:TV

metaM fum m
constant: false
initial concentration: 1.0
is: HMDB00134
boundary condition: false
name: Fumarate
initial amount: NaN
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false
is: SBO:0000247
is: C00122
type: Species

metaR r0395
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
is: SBO:0000176

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM dectricoa x
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
constant: false
has only substance units: false
name: 2,4,7-decatrienoylcoa
is: SBO:0000247

metaR FRDPtc
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport
fast: false

metaR r1621
modifier: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM ksi pre22 g
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: C00130
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 22
is: SBO:0000247
constant: false
is: HMDB00175

metaR CYTK10
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110028#
is: SBO:0000176
name: cytidylate kinase (CMP,dGTP)
is described by: ECO:0000269
type: Reaction
product: MODEL1310110028#

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaM 3deccrn c
name: 3-hydroxydecanoylcarnitine
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00651
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C17H33NO5 CHARGE: 0
type: Species

metaR G14T7g
product: MODEL1310110028#
fast: false
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
type: Reaction

metaR PHEACGLNt
name: PHEACGLN extracellular transport via diffusion
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
reversible: true
type: Reaction
is: SBO:0000185
fast: false

metaR ACNAMPH
is: SBO:0000176
fast: false
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: false
name: N-Acetylneuraminate 9-phosphate phosphohydrolase

metaR r0394
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false

metaR r1622
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
reversible: true

metaR CYTK11
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#
reversible: true
is: SBO:0000176
fast: false
name: cytidylate kinase (dCMP,dGTP)

metaM c12dc x
notes: FORMULA: C19H34NO6 CHARGE: -1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
is: HMDB11123
type: Species
is: C05279
name: dodecanedioyl carnitine

metaR C181CRNt
fast: false
name: C181 transport into the mitochondria
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000000
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
reversible: false
product: MODEL1310110028#

metaR RE1342C
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
name: RE1342
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000176

metaR HSD3A2r
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000000
kinetic law: MODEL1310110028#

metaR C4tmc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_a870319f_94ae_433f_94f7_2dec89d346b4
type: Species
is: D6RDW3
name: GUCY1A3
is encoded by: hsa:2982
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_192fac9c_8538_40f9_b3d3_77d87a17c21a
is encoded by: hsa:HG2846-HT2983
name: _HG2846_HT2983_1_m
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM co2 r
type: Species
constant: false
is: HMDB01967
name: CO2
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00011
is: CHEBI:16526
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial amount: NaN

metaR r0393
modifier: MODEL1310110028#
product: MODEL1310110028#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
reversible: false

metaR EX 3octdece1crn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaR CSBPASEly
reversible: false
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
product: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110028#

metaR CHOLATEt
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
name: cholate transport via bicarbonate countertransport
is: SBO:0000185
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#

metaM h x
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: C00080
type: Species
name: proton
is: http://identifiers.org/pubchem.compound/3380
constant: false
initial concentration: 1.0
is: CHEBI:24636
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_d66437a7_c16b_476a_96f8_8896539999e7
type: Species
name: PLCB4
constant: false
initial amount: NaN
is encoded by: hsa:5332
boundary condition: true
is: SBO:0000252
is: E2QRH8
initial concentration: NaN
has only substance units: false

metaR C10CRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR CHOLESTle
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/3.1.1.13
reversible: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
name: hydrolysis of cholesterol ester by cholesterol esterase

metaR FMNAT
reversible: false
is: SBO:0000176
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.7.2
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
is described by: ECO:0000134
modifier: MODEL1310110028#
type: Reaction
name: FMN adenylyltransferase
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false

metaR FAOXC142C122m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM 3hmbcoa m
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
has only substance units: false
is: SBO:0000247
is: CHEBI:57312
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01356

metaR r0392
kinetic law: MODEL1310110028#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
product: MODEL1310110028#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_e7be5687_8458_47a0_8616_fade0714dea2
is: SBO:0000252
name: LIPA
is encoded by: hsa:3988
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: P38571
initial amount: NaN

metaM adn e
is: HMDB00050
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: C00212
name: Adenosine
has only substance units: false
is: CHEBI:16335

metaR PRISTCOAtcx
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR PPD2CSPp
is: SBO:0000176
fast: false
reversible: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
is described by: ECO:0000000
product: MODEL1310110028#
name: PPD2CSPp
type: Reaction

metaR r1620
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_a078b782_e498_44a4_953e_3654318d6a4a
has only substance units: false
name: ADH6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P28332
type: Species
is encoded by: hsa:130
constant: false

metaR CSNAT2x
is version of: http://identifiers.org/ec-code/2.3.1.137
is: SBO:0000176
fast: false
reversible: true
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000269

metaR r0016
reactant: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1356.1) or (2495.1) or (2509.1) or (94033.1) or (84343.1) SUBSYSTEM: Miscellaneous EC Number: 1.16.3.1 Confidence Level: 0 AUTHORS: PMID:16405854,PMID:2154449,PMID:9162052,PMID:9722559 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: Fe(II):oxygen oxidoreductase Porphyrin and chlorophyll metabolism EC:1.16.3.1
is version of: http://identifiers.org/ec-code/1.16.3.1
type: Reaction
modifier: MODEL1310110028#

metaM pcrn c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/107738
has only substance units: false
name: propionyl-carnitine
type: Species
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: HMDB00824
constant: false

metaM 3octdece1crn c
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB13336
notes: FORMULA: C25H47NO5 CHARGE: 0
is: SBO:0000247
has only substance units: false
name: 3-hydroxy-octadecenoyl carnitine
initial amount: NaN

metaR OCDCEAtr
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
fast: false
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110028#

metaR NH4tp
reactant: MODEL1310110028#
is described by: ECO:0000000
name: ammonia peroxisomal transport
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110028#
fast: false
reversible: true

metaR CYTK14
name: cytidylate kinase (dCMP,UTP)
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM co2 x
is: SBO:0000247
name: carbon dioxide
is: HMDB01967
constant: false
type: Species
is: CHEBI:16526
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_54cc28b0_612d_4ddc_a94d_b2f2b450d000
name: SLC27A1
type: Species
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:376497
is: Q6PCB7
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM nrpphr e
constant: false
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:33569
boundary condition: false
name: Norepinephrine

metaM dttp m
constant: false
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
is: SBO:0000247
is: HMDB01342
has only substance units: false
is: C00459
boundary condition: false
initial concentration: 1.0
name: dTTP
initial amount: NaN

metaR CBASPte
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110028#
type: Reaction
reversible: true
fast: false
name: Transport of N-carbamoyl-L-aspartate
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_349b32d4_8a66_479a_85b0_82ad778a31e0
is: SBO:0000252
is: Q6TCH8
constant: false
is encoded by: hsa:10873
initial concentration: NaN
has only substance units: false
name: ME3
initial amount: NaN
boundary condition: true
type: Species

metaM ksi deg11 l
name: keratan sulfate I, degradation product 11
is: HMDB00143
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: CHEBI:12936
boundary condition: false
constant: false
initial amount: NaN

metaM 34dhpha c
name: (3,4-dihydroxyphenyl)acetate
boundary condition: false
constant: false
type: Species
is: CHEBI:17612
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01336

metaM 3dodtricoa m
initial amount: NaN
is: HMDB11123
initial concentration: 1.0
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
name: 3,6,9-dodecatrienoylcoa
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: C05279

metaM ksi pre6 g
type: Species
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 6
notes: FORMULA: C107H174N7O80SX CHARGE: -2
constant: false
is: HMDB00175
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58053
is: SBO:0000247
is: C00130

metaM acetol c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
is: SBO:0000247
initial amount: NaN
name: hydroxyacetone
initial concentration: 1.0
is: HMDB06961
is: CHEBI:27957
has only substance units: false
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_87dc39e8_fac4_40a8_9a21_f75f7d831110
is encoded by: hsa:1716
is: SBO:0000252
initial concentration: NaN
constant: false
name: DGUOK
initial amount: NaN
type: Species
is: E5KSL6
has only substance units: false
boundary condition: true

metaR RE1810M
fast: false
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
name: RE1810
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reactant: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_180374d5_46c1_488d_a173_205d1de476b5
is: SBO:0000252
has only substance units: false
is: P16885
is encoded by: hsa:5336
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
name: PLCG2

metaM xol7ah3 m
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB12455
boundary condition: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: CHEBI:28540
name: 5beta-cholestane-3alpha,7alpha,26-triol

metaR BILDGLCURtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
name: glucuronidated compound transport

metaM dttp n
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
has only substance units: false
is: CHEBI:37568
is: HMDB01342
initial amount: NaN
is: C00459
boundary condition: false
initial concentration: 1.0
constant: false
name: dTTP
type: Species

metaM tchola c
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
constant: false
type: Species
is: SBO:0000247
is: HMDB00036
boundary condition: false
initial concentration: 1.0
is: CHEBI:36257
has only substance units: false
initial amount: NaN
name: taurocholic acid

metaR DCYTt
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
kinetic law: MODEL1310110028#
type: Reaction
name: deoxycytidine transport via diffusion
is described by: ECO:0000000
product: MODEL1310110028#
is: SBO:0000185
reversible: true

metaR CYTK12
type: Reaction
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP)
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM 3octdece1crn e
name: 3-hydroxy-octadecenoyl carnitine
initial concentration: 1.0
type: Species
is: HMDB13336
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H47NO5 CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false

metaR RE0926E
is version of: http://identifiers.org/ec-code/3.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110028#
name: RE0926
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#

metaM 3mob m
name: 3-methyl-2-oxobutanoate
is: HMDB00019
is: CHEBI:11851
boundary condition: false
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial concentration: 1.0

metaM dhlam m
boundary condition: false
name: dihydrolipoamide
is: CHEBI:17694
is: HMDB00985
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_9ba141d4_2236_44a6_bfb0_c67611102433
is: P12074
name: COX6A1
has only substance units: false
is encoded by: hsa:1337
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_497b520e_5cdc_4c7c_86b6_bb7f2fb6df66
constant: false
boundary condition: true
is encoded by: hsa:230
is: SBO:0000252
initial concentration: NaN
is: P09972
initial amount: NaN
type: Species
name: ALDOC
has only substance units: false

metaR PIK3
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.137
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol 3-kinase
reversible: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.154
is: SBO:0000176
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
reactant: MODEL1310110028#

metaM dc2coa x
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01168
initial concentration: 1.0
constant: false
name: trans-Dec-2-enoyl-CoA
boundary condition: false
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaR r1851
reactant: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110028#
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_0590611e_796a_4ac3_8a09_bbd2a04f3740
initial concentration: NaN
name: PIGF
initial amount: NaN
is: Q6IB04
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:5281
has only substance units: false

metaR r2030
reversible: false
reactant: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR FAOXC2242046m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
type: Reaction
product: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110028#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_b6ba9b5b_e3a3_45a3_9155_feb859febf43
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:4124
boundary condition: true
initial amount: NaN
is: Q16706
name: MAN2A1

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR CYTK13
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reversible: true
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: cytidylate kinase (dCMP,dATP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110028#

metaM ksi pre8 g
is: SBO:0000247
is: CHEBI:28067
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 8
type: Species
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaR PTPATe
name: PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_1c0a2839_df2d_4540_8c5b_c09f3a61c048
name: AOC2
boundary condition: true
is encoded by: hsa:314
constant: false
has only substance units: false
initial amount: NaN
is: O75106
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_b3fec1c9_708d_4d5f_84ce_fbd47c83eeec
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is: P09622
constant: false
initial concentration: NaN
name: DLD
boundary condition: true
is encoded by: hsa:1738

metaM sphings c
is: CHEBI:57756
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
is: HMDB00252
initial concentration: 1.0
name: sphingosine(1+)
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247

metaR EX 3hdececrn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaR 3SPYRSPm
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_2f0cfc28_346f_4117_9e0d_714c9fee9a7d
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
is: O75912
is encoded by: hsa:9162
name: DGKI
initial concentration: NaN

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_3835935d_8535_4127_ab9b_ef813e647f00
initial amount: NaN
initial concentration: NaN
type: Species
name: B3GNT1
boundary condition: true
is: O43505
constant: false
is encoded by: hsa:11041
is: SBO:0000252
has only substance units: false

metaR NDPK1m
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
modifier: MODEL1310110028#
is described by: ECO:0000254
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reversible: true
reactant: MODEL1310110028#

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR RETI1
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinol isomerase (11-cis)
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
reversible: true
reactant: MODEL1310110028#
is: SBO:0000176
type: Reaction

metaR HEX10
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
type: Reaction
fast: false
reversible: false
is described by: ECO:0000212
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.1
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
name: hexokinase (D-glucosamine:ATP)

metaM 2ddecdicoa x
is: HMDB11123
is: C05279
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 2,6-dodecadienoylcoa
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_760ea6c9_81f9_4d32_87f8_c75b215ad7e6
has only substance units: false
is encoded by: hsa:2752
initial concentration: NaN
type: Species
is: P15104
is: SBO:0000252
initial amount: NaN
name: GLUL
constant: false
boundary condition: true

metaM 5adtststerone c
boundary condition: false
has only substance units: false
is: CHEBI:16330
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: HMDB02961
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species

metaM 3hdececrn c
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB02014
is: SBO:0000247
constant: false
type: Species
name: 3-hydroxyhexadecenoylcarnitine
notes: FORMULA: C23H43NO5 CHARGE: 0
has only substance units: false

metaM 2hb c
has only substance units: false
is: CHEBI:1148
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
constant: false
boundary condition: false
initial concentration: 1.0
name: 2-Hydroxybutyrate
is: HMDB00008

metaR 3HBCDm
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (55268.1) SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:NCD. rat gene that is homologous to the human gene encodes for this activity
name: 3-hydroxybutyryl-CoA dehydratase, mitochondrial
modifier: MODEL1310110028#
is: SBO:0000176
fast: false
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110028#_baa308ca_bbb0_4010_8013_ad5c82cfa696
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: NDUFV2
is encoded by: hsa:4729
constant: false
has only substance units: false
is: P19404
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_0da30db9_9b5e_43ba_afac_95879be9c822
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2717
initial concentration: NaN
initial amount: NaN
name: GLA
type: Species
is: Q53Y83
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a86ecafa_ad7c_46a5_b5f0_eb0e2802571f
is: O95864
type: Species
is encoded by: hsa:9415
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: FADS2
constant: false
boundary condition: true
initial concentration: NaN

metaR RETI2
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: retinol isomerase (9-cis)
reversible: true
reactant: MODEL1310110028#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
fast: false
is described by: ECO:0000000

metaR r1116
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR NH4tn
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: true
fast: false
name: ammonia nuclear transport
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_3178e70f_2bae_4cf1_aee5_97bed6d823bd
constant: false
has only substance units: false
is encoded by: hsa:AI971036
initial amount: NaN
name: _AI971036_1_m
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM dodecanac c
name: Dodecanedioic acid
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00623
constant: false
notes: FORMULA: C12H20O4 CHARGE: -2
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_03fca0c0_7263_4717_968f_09aa356790fb
boundary condition: true
is: P54709
is: SBO:0000252
constant: false
name: ATP1B3
initial concentration: NaN
is encoded by: hsa:483
type: Species
initial amount: NaN
has only substance units: false

metaR DNDPt48m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
modifier: MODEL1310110028#
fast: false
type: Reaction
name: dTTP transport via dGDP antiport
kinetic law: MODEL1310110028#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110028#
product: MODEL1310110028#

metaR LPASE
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.5
modifier: MODEL1310110028#
name: lysophospholipase
notes: GENE_ASSOCIATION: (5321.1) or (1178.1) or (29124.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9430701 NOTES:phosphatidyl choline degradation NJ
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_0f9fe678_e580_4c2c_9770_5c8ba3b1a36e
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:5092
type: Species
initial concentration: NaN
initial amount: NaN
name: PCBD1
is: SBO:0000252

metaR AG13T15g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
is described by: ECO:0000000
product: MODEL1310110028#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176
fast: false

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM kynate c
is: SBO:0000247
has only substance units: false
is: CHEBI:58454
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
boundary condition: false
is: HMDB00715
name: kynurenate
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species

metaM HC01610 e
is: SBO:0000247
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
name: CoproporphyrinogenI
is: CHEBI:28607
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false

metaM nrpphr c
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:33569
name: Norepinephrine

http://identifiers.org/biomodels.db/MODEL1310110028#_c056f29f_b86b_4d0f_bd83_59f50e28b7e4
initial amount: NaN
boundary condition: true
name: ATP1A3:ATP1B2
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:482
has only substance units: false
has part: P14415
constant: false
type: Species

metaR r1117
product: MODEL1310110028#
type: Reaction
reversible: true
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
fast: false
is: SBO:0000185
name: Facilitated diffusion
is described by: ECO:0000000

metaM mi145p c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: HMDB01498
constant: false
is: CHEBI:203600
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)

metaM 3hdececrn e
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C23H43NO5 CHARGE: 0
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892791
is: SBO:0000247
boundary condition: false
name: 3-hydroxyhexadecenoylcarnitine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_4c07bb6b_7767_4497_9c7d_72dfb4e234ee
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:291
constant: false
type: Species
has only substance units: false
is: P12235
name: SLC25A4
is: SBO:0000252

metaM hpdcacoa c
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
has only substance units: false
boundary condition: false
is: HMDB06497
constant: false

metaR FAS100COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
is: SBO:0000176
name: fatty acyl-CoA synthase (n-C10:0CoA)
reversible: false
modifier: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110028#

metaR GGH 10FTHF7GLUe
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
fast: false
is: SBO:0000176
modifier: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
reactant: MODEL1310110028#

metaM 2hb e
is: CHEBI:1148
type: Species
name: 2-Hydroxybutyrate
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial concentration: 1.0
boundary condition: false
is: HMDB00008

metaM HC00229 e
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28189
initial concentration: 1.0
name: Isomaltose

http://identifiers.org/biomodels.db/MODEL1310110028#_0ac6badc_2977_488b_9953_1dba303fba95
is encoded by: hsa:23533
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: PIK3R5
is: Q8WYR1
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM lald L c
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18041
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
name: (S)-lactaldehyde
is: HMDB03052

metaM arachdcoa x
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57368
is: HMDB06523
name: arachidonoyl-CoA(4-)
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species

metaM 3decdicoa m
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: 3,7-decadienoylcoa
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM tchola e
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0
is: SBO:0000247
is: HMDB00036
initial amount: NaN
boundary condition: false
type: Species
name: taurocholic acid
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_a135fa9b_a97a_44f8_a23a_2c47858265cf
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:10476
is: O75947
name: ATP5H
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaM ctp n
type: Species
has only substance units: false
is: CHEBI:37563
is: SBO:0000247
initial amount: NaN
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
constant: false
is: HMDB00082
initial concentration: 1.0
boundary condition: false

metaM HC01501 c
boundary condition: false
constant: false
initial amount: NaN
name: hydroxidodioxidosulfidosulfate(1-)
notes: FORMULA: HO3S2 CHARGE: -1 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-1 EHMN_ABBREVIATION: C05529
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:33539
type: Species

metaR r0590
reversible: false
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
product: MODEL1310110028#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_8adac4a7_5836_40e5_9398_37076c96d764
is: B2RAT6
is encoded by: hsa:2592
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: GALT
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR DTMPK
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.9
name: dTMP kinase
reversible: true
product: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
is described by: ECO:0000269

metaM ditp n
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species
initial amount: NaN
is: CHEBI:61382
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: dITP(4-)
is: HMDB03537
is: SBO:0000247

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaM 2oxoadp c
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
constant: false
name: 2-oxoadipate(2-)
is: CHEBI:57499
initial concentration: 1.0
is: HMDB00225
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_425a32e9_d131_43bd_bc23_afffea650651
initial concentration: NaN
name: _AA576959_1_c
boundary condition: true
is encoded by: hsa:AA576959
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM Rtotal c
boundary condition: false
notes: FORMULA: CO2FULLR CHARGE: -1
is: CHEBI:16189
name: R total
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01448

http://identifiers.org/biomodels.db/MODEL1310110028#_c86ff102_1afc_430f_8427_ecef32548db0
name: SDHB
is: SBO:0000252
type: Species
initial concentration: NaN
is: P21912
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:6390
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_186c0ea6_1422_40f1_8d55_bb5a36c2282f
name: GALT
constant: false
is: B2RAT6
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:2592

metaR r1547
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_f65f6cdc_a81c_4917_8272_874abc41b5b6
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
name: RPN2
has only substance units: false
is encoded by: hsa:6185
is: P04844
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_3b66fdf2_86f3_4da1_be64_2155c765d20a
is: SBO:0000252
is encoded by: hsa:501
type: Species
name: ALDH7A1
boundary condition: true
initial concentration: NaN
is: E7EPT3
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_d877e880_a2e5_417a_a746_c4c6808ea8b7
is encoded by: hsa:126328
name: NDUFA11
is: C9JT23
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species

metaM sbcoa x
is: SBO:0000247
has only substance units: false
name: suberylcoa
boundary condition: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966

metaR r0591
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
reactant: MODEL1310110028#
type: Reaction
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
reversible: true

metaR r1619
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110028#

metaM dtmp c
constant: false
is: CHEBI:26999
initial amount: NaN
has only substance units: false
is: C00364
name: dTMP
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
is: HMDB01227
is: SBO:0000247

metaR KYNATESYN
fast: false
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000176
reversible: false
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
product: MODEL1310110028#

metaM ksi deg40 l
has only substance units: false
constant: false
notes: FORMULA: C40H68N2O31 CHARGE: 0
initial amount: NaN
name: keratan sulfate I, degradation product 40
is: CHEBI:12936
initial concentration: 1.0
type: Species
is: HMDB00143
boundary condition: false
is: SBO:0000247

metaR CYSO
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
fast: false
type: Reaction
reversible: false
name: cysteine oxidase
is version of: http://identifiers.org/ec-code/1.13.11.20
modifier: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#

metaR LNELDCt
is described by: ECO:0000000
product: MODEL1310110028#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185
reactant: MODEL1310110028#
fast: false
type: Reaction
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_04911476_9578_4493_b6a0_1463442ce231
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:5152
is: SBO:0000252
name: PDE9A
type: Species
initial concentration: NaN
has only substance units: false

metaR r1546
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110028#

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM c12dc c
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00623
name: dodecanedioyl carnitine
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C19H34NO6 CHARGE: -1

metaM gacpail hs r
is: SBO:0000247
boundary condition: false
is: HMDB01401
has only substance units: false
is: C00092
type: Species
initial amount: NaN
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
name: glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0

metaR r1549
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#

metaR FACOAL1813
reactant: MODEL1310110028#
name: fatty-acid--CoA ligase
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false

metaR 1PPDCRp
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
is: SBO:0000176
name: delta1-piperideine-2-carboxylate reductase, perixosomal
product: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
type: Reaction

metaM prpp e
is: HMDB00280
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
is: CHEBI:58017
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_eb524157_bb0d_4d9a_93bb_195c21ebfd4f
constant: false
initial amount: NaN
name: CA1
type: Species
is encoded by: hsa:759
boundary condition: true
is: P00915
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR LNLNCGCRNt
reactant: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_d65ea095_658f_49ad_a97e_4dfd4af0ce2c
constant: false
is: Q08828
is encoded by: hsa:107
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: ADCY1
has only substance units: false

metaM ipdp x
is: HMDB01347
is: CHEBI:128769
constant: false
initial amount: NaN
name: isopentenyl diphosphate(3-)
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129

metaR NTD11
reversible: false
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (IMP)
type: Reaction
modifier: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000269
product: MODEL1310110028#

metaM cs e deg2 l
is: SBO:0000247
is: HMDB01354
boundary condition: false
is: CHEBI:57455
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
initial amount: NaN
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
initial concentration: 1.0
type: Species
has only substance units: false

metaR S6T1g
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110028#_bc21fe0d_c12f_4e6c_bdcb_adfcd9b51423
constant: false
name: FDFT1
is encoded by: hsa:2222
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: P37268

metaR r0245
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_14853f40_9978_41d9_800f_dc397d5d20d7
name: _NM_013421_1_e
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:NM 013421

http://identifiers.org/biomodels.db/MODEL1310110028#_666faf47_555f_4cdc_b997_d167080be69b
constant: false
is: SBO:0000252
name: _AI640625_1_c
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AI640625
initial amount: NaN

metaM pydx5p c
is: HMDB01491
name: Pyridoxal 5'-phosphate
boundary condition: false
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
initial concentration: 1.0
is: CHEBI:597326
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: C00018
has only substance units: false

metaR PHCHGSm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110028#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
is: SBO:0000176
reactant: MODEL1310110028#

metaR GLAl
modifier: MODEL1310110028#
type: Reaction
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
name: galactosidase, alpha
is version of: http://identifiers.org/ec-code/3.2.1.22
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ

metaR HISTAtu
type: Reaction
modifier: MODEL1310110028#
name: Histamine uniport
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110028#

metaR MI1P Dtn
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
name: inositol 1-phosphate nuclear transport (diffusion)
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_fb365366_941a_47d4_8bbc_fdbe1ede9c18
is: SBO:0000252
constant: false
has only substance units: false
name: ADCY8
type: Species
is encoded by: hsa:114
initial amount: NaN
initial concentration: NaN
is: Q4F7X0
boundary condition: true

metaM icit x
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: isocitrate(3-)
is: HMDB00193
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_cc42e274_5302_4fbf_b7fb_64f59ff31ee7
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AI971036
name: _AI971036_1_c

metaM dtmp e
name: dTMP(2-)
initial amount: NaN
is: CHEBI:26999
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
is: HMDB01227
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM xol7ah3 c
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: CHEBI:28540
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
boundary condition: false
is: HMDB12455
constant: false
initial concentration: 1.0
type: Species

metaR r0246
reversible: false
product: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is: SBO:0000176
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
type: Reaction

metaR r1548
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM prpp c
initial concentration: 1.0
boundary condition: false
is: CHEBI:58017
type: Species
has only substance units: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: HMDB00280
is: C00119
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_6aab0470_8218_4ed7_8696_10a647854e6e
initial concentration: NaN
boundary condition: true
is: Q16873
is: SBO:0000252
has only substance units: false
constant: false
name: LTC4S
is encoded by: hsa:4056
type: Species
initial amount: NaN

metaR ALCD2yf
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000134
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
fast: false
reversible: false
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
reactant: MODEL1310110028#
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_e07d5548_db8d_4e7d_9976_9fc8fbdaa085
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P15531
name: NME1
boundary condition: true
constant: false
is encoded by: hsa:4830
is: SBO:0000252
type: Species

metaM pmtcoa c
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
is: C00154
initial concentration: 1.0
is: CHEBI:3454
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)

metaM ksi deg21 l
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00143
constant: false
type: Species
is: CHEBI:12936
name: keratan sulfate I, degradation product 21

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR r0594
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reactant: MODEL1310110028#

metaM xylt c
initial concentration: 1.0
is: CHEBI:17151
is: HMDB02917
name: xylitol
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false

metaM glyald m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01051
name: D-glyceraldehyde
initial amount: NaN

metaR UMPK3
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP)
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
is described by: ECO:0000269
fast: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR PHACCOAGLNAC
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
reactant: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_dfd8e138_b441_47bc_b784_d4d3dd625a77
initial amount: NaN
is encoded by: hsa:2974
is: SBO:0000297
constant: false
has only substance units: false
has part: D6RDW3
is encoded by: hsa:2982
initial concentration: NaN
name: GUCY1B2:GUCY1A3
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_4dd4bd07_9a24_4f55_8ca2_9f671d59a39d
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:222
boundary condition: true
name: ALDH3B2
initial concentration: NaN
has only substance units: false
constant: false
is: P48448
type: Species

metaR LEUKTRE4t
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene E4 transport

metaM urea m
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial amount: NaN
is: HMDB00294
constant: false
boundary condition: false
type: Species
is: CHEBI:16199
name: Urea
is: SBO:0000247
is: C00086
has only substance units: false
initial concentration: 1.0

metaR r0595
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
reactant: MODEL1310110028#
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110028#
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
type: Reaction
reversible: false

metaM ksi pre25 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 25
initial amount: NaN
is: C00130
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: HMDB00175
boundary condition: false
has only substance units: false
is: CHEBI:58053
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_3adb2d99_bb79_4037_bab8_c359e892e0fa
is: SBO:0000297
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:518
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
initial amount: NaN

metaM hxcoa m
is: HMDB06522
name: Hexanoyl-CoA (n-C6:0CoA)
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species

metaM C05280 m
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
name: cis,cis-3,6-Dodecadienoyl-CoA
is: CHEBI:28002
is: SBO:0000247
is: HMDB03952
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280

metaR FACOAL1812
is: SBO:0000176
kinetic law: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
name: fatty-acid--CoA ligase
fast: false

metaR MGCHrm
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
is: SBO:0000176
reactant: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18
is described by: ECO:0000269
modifier: MODEL1310110028#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_60752da8_76b2_4842_a6f0_c16c904d2f5f
is: SBO:0000252
type: Species
constant: false
is: G3V5N0
has only substance units: false
initial amount: NaN
is encoded by: hsa:2530
boundary condition: true
initial concentration: NaN
name: FUT8

http://identifiers.org/biomodels.db/MODEL1310110028#_ebd1ef78_9e98_4b8c_941d_093f1712824a
has only substance units: false
name: AACS
is encoded by: hsa:65985
type: Species
constant: false
is: Q86V21
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM CE5119 m
is: CHEBI:57923
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
name: trans-3-cis-8-tetradecadienoyl-CoA
boundary condition: false
initial concentration: 1.0

metaR UMPK2
product: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
name: UMP kinase (CTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM pcrn m
type: Species
initial concentration: 1.0
is: HMDB00824
name: propionyl-carnitine
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/107738
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3

metaM ttetddcoa m
is: HMDB02288
type: Species
constant: false
name: trans5,8tetradecadienoylcoa
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false

metaR RE1796M
reversible: true
name: RE1796
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.145
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_c8d1aacc_b1e5_479e_bc4d_e87bbf964e51
has only substance units: false
is: D3DX95
name: CHAT
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:1103
constant: false
boundary condition: true

metaR FAOXC163GC142m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR r0596
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reactant: MODEL1310110028#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#

metaR PROSTGF2t
modifier: MODEL1310110028#
reversible: true
name: prostaglandin uniport
is described by: ECO:0000269
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
product: MODEL1310110028#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110028#

metaM pro L m
is: SBO:0000247
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
boundary condition: false
is: CHEBI:17203
initial amount: NaN
has only substance units: false
name: L-proline
is: HMDB00162
initial concentration: 1.0

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaR UMPK5
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
name: UMP kinase (dATP)
product: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM 3decdicoa x
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
name: 3,7-decadienoylcoa
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_4bb03ac6_a2fd_482b_9405_da3e248ce3f6
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: GALNT3
boundary condition: true
is encoded by: hsa:2591
is: Q14435
is: SBO:0000252
initial concentration: NaN

metaM Rtotal e
is: C00255
boundary condition: false
constant: false
name: R total
notes: FORMULA: CO2FULLR CHARGE: -1
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:3554
is: HMDB00244
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_498d7c9a_b77a_46a1_bd76_9d7c7b19ac4a
initial concentration: NaN
is encoded by: hsa:522
initial amount: NaN
has part: O75947
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:10476
is: SBO:0000297
has part: P18859
has only substance units: false
is encoded by: hsa:515
type: Species
has part: P24539
is encoded by: hsa:518
boundary condition: true

metaM cmp c
name: CMP
is: HMDB00095
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:60377
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
is: SBO:0000247
is: C00055

metaM co2 c
is: CHEBI:3313
name: CO2
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01967
is: C00011

metaR r1544
fast: false
is: SBO:0000185
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_b433fd43_66be_4506_bfb8_b8c8c496d644
is encoded by: hsa:1892
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
name: ECHS1
initial concentration: NaN
is: SBO:0000252
is: P30084
constant: false

metaR UMPK4
product: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110028#
fast: false
reversible: true
reactant: MODEL1310110028#
is: SBO:0000176
name: UMP kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR ENGASE2ly
product: MODEL1310110028#
reversible: false
kinetic law: MODEL1310110028#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110028#
name: endo-beta-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false

metaR FACOAL80i
reversible: false
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110028#
name: fatty-acid--CoA ligase (octanoate)
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
type: Reaction

metaR r0181
reactant: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110028#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
kinetic law: MODEL1310110028#

metaR TETDECE1CRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaR r0242
reactant: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
product: MODEL1310110028#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is version of: http://identifiers.org/ec-code/6.2.1.1
type: Reaction

metaR FAOXC102C103m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_835038f9_e5aa_4d42_bb1a_2e22884c7954
is: SBO:0000252
initial concentration: NaN
is: A8K3J4
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:23632
name: CA14
boundary condition: true
has only substance units: false

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_f33a5c74_ab0c_4e05_9baa_df9a05f365a3
boundary condition: true
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: ESCO2
is: SBO:0000252
is encoded by: hsa:157570
is: Q56NI9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ff0ee690_fd71_4f6a_b5de_4b7cd382bf9d
constant: false
is encoded by: hsa:516
has only substance units: false
name: ATP5G1
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: P05496
is: SBO:0000252

metaR r1612
reactant: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM glyc3p c
is: HMDB00126
boundary condition: false
type: Species
is: SBO:0000247
is: C00093
initial amount: NaN
is: CHEBI:57597
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
has only substance units: false
constant: false
name: Glycerol 3-phosphate

http://identifiers.org/biomodels.db/MODEL1310110028#_71616cff_8ed5_4d22_a11e_3ff8ac4f816e
is: SBO:0000252
has only substance units: false
type: Species
name: _BF195998_1_x
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:BF195998
initial concentration: NaN

metaM 3deccrn e
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C17H33NO5 CHARGE: 0
name: 3-hydroxydecanoylcarnitine
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB02250
type: Species

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_d1ac5928_80c3_4ffa_ac45_c8e5f94823a2
is: SBO:0000297
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: NME1:NME2
initial concentration: NaN
is encoded by: hsa:4831
has part: P15531
boundary condition: true
is encoded by: hsa:4830
has part: P22392

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaR ALDD2x
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
name: aldehyde dehydrogenase (acetaldehyde, NAD)
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_3d80d985_596f_4a16_8284_04fba6d0bc88
initial concentration: NaN
name: RPIA
initial amount: NaN
is encoded by: hsa:22934
has only substance units: false
constant: false
is: SBO:0000252
is: P49247
type: Species
boundary condition: true

metaR r1611
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
kinetic law: MODEL1310110028#

metaM lnlncgcoa m
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
has only substance units: false
is: CHEBI:57363
is: HMDB06368
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_8f8d4c2f_1d3f_4b7a_b0f9_8ae156048f41
constant: false
is: SBO:0000252
is encoded by: hsa:54995
boundary condition: true
has only substance units: false
name: OXSM
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9NWU1

metaM co2 e
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
type: Species
is: HMDB01967
initial concentration: 1.0
initial amount: NaN
is: C00011
is: SBO:0000247
name: CO2
has only substance units: false
is: CHEBI:16526
constant: false

metaM cmp e
boundary condition: false
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
initial concentration: 1.0
is: HMDB00095
initial amount: NaN
is: CHEBI:60377
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_e54a13e5_c010_4e92_a20c_4df8464ef2f5
is encoded by: hsa:3418
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: IDH2
type: Species
is: P48735
is: SBO:0000252

metaR ALDD2y
product: MODEL1310110028#
fast: false
reversible: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
name: aldehyde dehydrogenase (acetaldehyde, NADP)
reactant: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR SO4t4 2
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
type: Reaction
name: sulfate transport via sodium symport
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_c0704e44_62eb_4aef_abac_97975cc8934a
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
name: GPX2
is: P18283
is encoded by: hsa:2877
type: Species
is: SBO:0000252

metaR GCC2bim
modifier: MODEL1310110028#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110028#
is described by: ECO:0000269
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM hmgcoa c
boundary condition: false
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaR TTDCPT2
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
fast: false

metaR r1614
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110028#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#

metaR ACGPID
name: N-acetylglucosaminylphosphatidylinositol deacetylase
is version of: http://identifiers.org/ec-code/3.5.1.89
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110028#

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR HSAT1ly
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110028#
reversible: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
type: Reaction
product: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#

metaR SIAASE4ly
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: false
is described by: ECO:0000000
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110028#

metaR TTDCPT1
is: SBO:0000176
modifier: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: carnitine O-palmitoyltransferase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false

metaR LACLt
kinetic law: MODEL1310110028#
reversible: false
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110028#
fast: false
name: Lactate transport

metaR r1540
reactant: MODEL1310110028#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
modifier: MODEL1310110028#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
fast: false
type: Reaction
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110028#
is described by: ECO:0000000

metaR FAOXC81C61m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR r1613
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110028#

metaR S6T17g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110028#
reversible: false
type: Reaction

metaM dtmp m
has only substance units: false
name: dTMP
type: Species
initial concentration: 1.0
is: CHEBI:26999
is: C00364
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: HMDB01227
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR NACHEX23ly
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is: SBO:0000176
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR r0399
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
modifier: MODEL1310110028#
reversible: true
is: SBO:0000176
product: MODEL1310110028#

metaR DESAT22 1p
reactant: MODEL1310110028#
is: SBO:0000176
reversible: false
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110028#

metaM cmp g
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
is: HMDB00095
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:60377
name: CMP(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_9a9efc14_b6d7_43ae_9a9c_21a96adb2eb5
name: ACAD9
initial concentration: NaN
is: SBO:0000252
is: Q9H845
boundary condition: true
constant: false
type: Species
is encoded by: hsa:28976
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_485e39dc_3adb_46cf_92cf_d04e2798e00d
name: AFMID
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:125061
is: Q63HM1
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false

metaR TALA
name: transaldolase
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.2
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction

metaR r0488
reactant: MODEL1310110028#
reversible: true
is: SBO:0000176
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110028#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34

metaR OCD11COACPT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM pro L c
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00162
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r0186
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2

metaR GTHDH
product: MODEL1310110028#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
is described by: ECO:0000134
name: Glutathione dehydrogenase (dehydroascorbate reductase)
reactant: MODEL1310110028#

metaR FALDH
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000269
modifier: MODEL1310110028#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
type: Reaction
name: formaldehyde dehydrogenase

metaR CSNAT2m
is: SBO:0000176
reversible: true
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.7
reactant: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
is described by: ECO:0000000
name: carnitine O-aceyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
kinetic law: MODEL1310110028#
type: Reaction

metaR ACOAO7p
fast: false
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
product: MODEL1310110028#
modifier: MODEL1310110028#
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR GLNATB0tc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Glutamine into the intestinal cells by ATB0 transporter
type: Reaction

metaM CE1617 r
type: Species
is: HMDB01358
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8-,16-14+ EHMN_ABBREVIATION: CE1617
constant: false
initial concentration: 1.0
is: CHEBI:17898
name: 9-cis-retinoate

metaR r1616
fast: false
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110028#
reversible: true

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_8e601d48_aaa6_4e10_8d23_0979a04ab19a
name: RPE
is encoded by: hsa:6120
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q53TV9

metaR XOLDIOLONEt
reversible: true
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
fast: false

metaR CLPNDCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110028#
name: fatty acid intracellular transport

metaR HEXDCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaM fum c
type: Species
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
has only substance units: false
is: C00122
boundary condition: false
is: HMDB00134
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Fumarate
constant: false
is: CHEBI:29806

metaR C141OHe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR NOt
reversible: true
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
is: SBO:0000185
name: NO transport (diffusion)
reactant: MODEL1310110028#

metaR NDP8
is described by: ECO:0000269
name: nucleoside-diphosphatase (dUDP)
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.9
is: SBO:0000176
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: false
kinetic law: MODEL1310110028#
type: Reaction

metaM urea e
initial concentration: 1.0
is: HMDB00294
is: C00086
boundary condition: false
has only substance units: false
is: CHEBI:16199
initial amount: NaN
is: SBO:0000247
name: Urea
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
type: Species
constant: false

metaR HISD
kinetic law: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is version of: http://identifiers.org/ec-code/4.3.1.3
modifier: MODEL1310110028#
fast: false
product: MODEL1310110028#
is described by: ECO:0000269
name: histidase
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000176

metaR AATAi
reactant: MODEL1310110028#
is described by: ECO:0000269
name: 2-aminoadipate transaminase, irreversible
fast: false
product: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.7
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
reversible: false

metaM 2docohexecoa m
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
name: 2,7,10,13,16,19-docosahexenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0

metaM dcacoa c
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
initial concentration: 1.0
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
boundary condition: false
is: HMDB06404
is: SBO:0000247
is: C05274
type: Species
has only substance units: false
initial amount: NaN

metaR CYTK14n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
reversible: true

metaR FADH2ETC
product: MODEL1310110028#
name: Complex II reaction for respiratory chain
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
reversible: false

metaR r1615
product: MODEL1310110028#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is described by: ECO:0000000

metaR PROSTGE2t
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110028#
fast: false
name: prostaglandin transport via bicarbonate countertransport
reversible: true
modifier: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_40da2d46_d131_43eb_b24d_a42de3c52a8a
initial concentration: NaN
name: ACO1
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:48
is: P21399
is: SBO:0000252

metaR GLNtN1
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110028#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
name: Glutamine transport (Na, H coupled)

http://identifiers.org/biomodels.db/MODEL1310110028#_a5517d5a_13a4_452f_b0de_cb47ad372d88
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: ALG1
is: Q9BT22
has only substance units: false
is encoded by: hsa:56052
is: SBO:0000252

metaR r0249
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
reversible: true
is: SBO:0000176
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
reactant: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_92ab70a7_4e59_40bb_b1f9_7d8fab0e45d9
name: BCAT1
has only substance units: false
initial amount: NaN
is encoded by: hsa:586
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: P54687
initial concentration: NaN

metaM lnlncgcoa r
initial amount: NaN
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
is: SBO:0000247
is: CHEBI:57363
has only substance units: false
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
constant: false
type: Species

metaR FBP
product: MODEL1310110028#
is: SBO:0000176
name: fructose-bisphosphatase
reactant: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2203.1) or (8789.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.11 Confidence Level: 0 AUTHORS: PMID:9678974 NOTES:SMP
is version of: http://identifiers.org/ec-code/3.1.3.11
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_327c96cb_ddcb_45cc_9174_28aa65620603
boundary condition: true
is: P00491
constant: false
initial amount: NaN
name: PNP
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:4860
is: SBO:0000252

metaM pro L e
has only substance units: false
name: L-proline
is: HMDB00162
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
type: Species
is: CHEBI:17203
initial amount: NaN

metaM pcrn x
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/107738
is: SBO:0000247
type: Species
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00824
name: propionyl-carnitine

http://identifiers.org/biomodels.db/MODEL1310110028#_db6651a1_0c00_4557_8be3_f3ef6e986a3d
has only substance units: false
type: Species
initial concentration: NaN
name: SLC4A5
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:57835

metaR FAOXC5C5OHm
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR r0483
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#

metaR RE3000M
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3000
modifier: MODEL1310110028#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true

metaM pmtcoa m
type: Species
has only substance units: false
is: HMDB01338
is: SBO:0000247
is: CHEBI:57379
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154

http://identifiers.org/biomodels.db/MODEL1310110028#_cb03f7c8_2902_40db_bfef_c9a5cfac6704
name: FAH
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: P16930
is encoded by: hsa:2184

metaM icit m
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00193
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311
constant: false
initial concentration: 1.0
name: Isocitrate
type: Species
is: CHEBI:16087

http://identifiers.org/biomodels.db/MODEL1310110028#_ae270ee6_746b_43b8_ac2c_0e6e9efa8b36
has only substance units: false
is: O00476
name: SLC17A3
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10786
constant: false

metaR CYOOm3
reversible: false
kinetic law: MODEL1310110028#
name: cytochrome c oxidase, mitochondrial Complex IV
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is: SBO:0000185
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.9.3.1
modifier: MODEL1310110028#
fast: false
type: Reaction

metaR r1618
type: Reaction
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ca2eef01_422e_45ee_ab61_6a1ec5b45e42
name: ECH1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1891
is: Q13011
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN

metaM urea c
initial concentration: 1.0
is: SBO:0000247
is: C00086
type: Species
name: Urea
is: CHEBI:16199
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: HMDB00294
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086

http://identifiers.org/biomodels.db/MODEL1310110028#_dbbfc8d9_ad37_4e15_95a0_ba0863b6259e
constant: false
type: Species
is: SBO:0000297
is encoded by: hsa:8818
is encoded by: hsa:5277
initial amount: NaN
has part: P37287
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM zymst r
name: zymosterol
is: SBO:0000247
is: HMDB06271
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
has only substance units: false
initial concentration: 1.0
is: CHEBI:18252
type: Species
boundary condition: false
constant: false

metaR FAOXC16180m
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
is: SBO:0000176
name: Beta oxidation fatty acid
reactant: MODEL1310110028#
reversible: false
product: MODEL1310110028#

metaR C141OHc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_11e70f35_b461_4f6a_9cfc_0d66aab5755a
initial concentration: NaN
initial amount: NaN
name: SLC26A6
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: Q548A7
boundary condition: true
is encoded by: hsa:65010

metaM acgpail hs c
has only substance units: false
initial concentration: 1.0
type: Species
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57265
boundary condition: false

metaR ACETONEt2
product: MODEL1310110028#
name: acetone transport via proton symport
reversible: true
modifier: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_6b1d5d88_a83e_4d10_b3bc_c66330686c2c
type: Species
initial amount: NaN
is: Q9UBK5
is encoded by: hsa:10870
has only substance units: false
constant: false
name: HCST
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR SIAASEly
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
name: sialidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR AMPtp
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
reversible: true
type: Reaction
product: MODEL1310110028#
name: AMP transporter, peroxisome

http://identifiers.org/biomodels.db/MODEL1310110028#_f418c1bb_9b33_4edb_94f6_f082ad0a6f4e
initial amount: NaN
name: _AV727634_1_c
boundary condition: true
is encoded by: hsa:AV727634
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM dmpp x
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57623
constant: false
is: HMDB01120
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
name: prenyl diphosphate(3-)
boundary condition: false

metaR r1617
is: SBO:0000185
product: MODEL1310110028#
reversible: true
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_f56a01c4_4e25_41d1_a8ea_a8c565a466a9
name: PTS
is: Q03393
is encoded by: hsa:5805
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_cdea9a53_c165_4541_a322_b381d34336aa
type: Species
name: ALDH3A2
is encoded by: hsa:224
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P51648
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_85052482_5438_4145_9956_40e0aa5bfb5b
is: SBO:0000252
is: P21953
has only substance units: false
initial concentration: NaN
is encoded by: hsa:594
name: BCKDHB
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR LYStip
name: L-lysine transport, peroxisomal (irreversible)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185

metaM ps hs m
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: ps_hs[m]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:18303

metaR PI4PLCn
kinetic law: MODEL1310110028#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
fast: false

metaM dodecanac x
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00623
constant: false
initial amount: NaN
notes: FORMULA: C12H20O4 CHARGE: -2
name: Dodecanedioic acid

metaM udp r
name: UDP
is: C00015
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00295
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaR FAOXC81C61x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaR SPC HSt
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
reactant: MODEL1310110028#
name: sphingosylphosphorylcholine transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110028#_5a47e4f7_d681_4557_983b_775e86b882ee
is encoded by: hsa:115
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: ADCY9
initial concentration: NaN
constant: false
is: O60503
has only substance units: false

metaM retn e
constant: false
is: HMDB01852
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247
name: all-trans-retinoate
initial concentration: 1.0

metaR r0179
is: SBO:0000176
modifier: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reversible: true
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000

metaR GUAt
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
fast: false
is: SBO:0000185
name: Guanine transport
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
is described by: ECO:0000269
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: true

metaR r1109
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_5f8aa0e3_e1e6_49d5_a7eb_a9795b1cc015
is: SBO:0000252
name: HK1
initial amount: NaN
is: P19367
boundary condition: true
is encoded by: hsa:3098
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR C5DCe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_75e5d497_f946_4f6a_86cd_31c7ecbf23f7
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:412
is: P08842
boundary condition: true
has only substance units: false
name: STS
initial concentration: NaN
constant: false

metaR r0178
fast: false
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is version of: http://identifiers.org/ec-code/2.5.1.21
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
modifier: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176

metaR GASNASEly
reversible: false
is: SBO:0000176
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.26
name: glycosylasparaginase, lysosomal
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM pmtcoa x
is: HMDB01338
boundary condition: false
is: SBO:0000247
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
type: Species
initial amount: NaN
is: CHEBI:57379
is: C00154
initial concentration: 1.0
has only substance units: false

metaM melatn c
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598
is: HMDB01389
initial concentration: 1.0
name: melatonin
is: CHEBI:16796

metaR GULN3D
is: SBO:0000176
reactant: MODEL1310110028#
type: Reaction
reversible: true
kinetic law: MODEL1310110028#
fast: false
name: L-gulonate 3-dehydrogenase
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000

metaM hs deg24 l
has only substance units: false
name: GlcNAc-GlcA-(Gal)2-Xyl
initial concentration: 1.0
is: CHEBI:16126
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H50NO26 CHARGE: -1
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_5b85fa54_44f5_4eeb_9a9f_d6a1cf044a4e
constant: false
has only substance units: false
name: _7359_1_c
type: Species
is encoded by: hsa:7359
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR PROSTGE1t
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reactant: MODEL1310110028#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000269

metaM glyald c
name: D-Glyceraldehyde
is: C00577
is: HMDB01051
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:17378

metaR DOLPMT4 Uer
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110028#
reversible: false
kinetic law: MODEL1310110028#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_43294e3b_8000_4bfd_9d5e_a5bc132e7bd7
constant: false
has only substance units: false
type: Species
name: DPM2
is encoded by: hsa:8818
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM gacpail hs c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: glucosaminyl-acylphosphatidylinositol
is: HMDB01401
has only substance units: false
is: C00092
type: Species
constant: false
initial amount: NaN
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110028#_2fc3d9a6_7ae0_4e43_9b85_9778f6411781
name: IDUA
type: Species
is encoded by: hsa:3425
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P35475
constant: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_d99d66de_627a_43bf_a13a_8c9a74c2b717
initial amount: NaN
has only substance units: false
constant: false
name: ND2
boundary condition: true
type: Species
is encoded by: hsa:4536
is: Q7GXY9
is: SBO:0000252
initial concentration: NaN

metaR r1106
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110028#
name: Postulated transport reaction
product: MODEL1310110028#

metaR DOLPH Uer
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
fast: false
reversible: false
is: SBO:0000176
name: Dolichol-phosphate phosphohydrolase, human (uterus)
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_4d193d54_9a5d_44d6_b6ea_414468714ea1
is: Q02218
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: OGDH
is encoded by: hsa:4967
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM dadp m
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: HMDB01508
constant: false
is: CHEBI:57667
name: dADP(3-)
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR FAOXC141C121x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C14:1-->C12:1)x
type: Reaction

metaM retn c
name: all-trans-retinoate
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01852
is: CHEBI:35291
is: SBO:0000247

metaM ksi deg10 l
is: CHEBI:57455
type: Species
initial amount: NaN
is: HMDB01354
constant: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I, degradation product 10
boundary condition: false
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
has only substance units: false

metaR ACGAMPM
is version of: http://identifiers.org/ec-code/5.4.2.3
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
fast: false
product: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
name: phosphoacetylglucosamine mutase

http://identifiers.org/biomodels.db/MODEL1310110028#_3a0349eb_659a_4166_8e99_55aad20cb892
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:4047
is: E9PEI9
constant: false
boundary condition: true
initial amount: NaN
name: LSS

metaM dcsptn1crn c
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06321
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl carnitine

metaR MI134P4P
product: MODEL1310110028#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
is described by: ECO:0000000
name: inositol-1,3,4-trisphosphate 4-phosphatase
fast: false

metaR TETTET6t
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
name: fatty acid transport via diffusion
is described by: ECO:0000000

metaM CE2839 e
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: SBO:0000247
is: C01936
type: Species
has only substance units: false
constant: false
name: maltodecaose
initial concentration: 1.0
boundary condition: false

metaR GLCt4
modifier: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
name: glucose transport via sodium symport
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000185
product: MODEL1310110028#
is described by: ECO:0000269

metaR INSt
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
name: Inosine transport (diffusion)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
reversible: true
modifier: MODEL1310110028#
fast: false
type: Reaction
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_a8e64121_56a5_4dd4_9a8d_e4a2f9c07441
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ATP5F1
type: Species
is encoded by: hsa:515
initial concentration: NaN
is: P24539

http://identifiers.org/biomodels.db/MODEL1310110028#_122f71fc_1c86_46a4_a158_144244f3caee
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is: P42126
has only substance units: false
boundary condition: true
initial amount: NaN
name: ECI1
is encoded by: hsa:1632

http://identifiers.org/biomodels.db/MODEL1310110028#_52209240_6cee_4a73_8848_77c242bbc397
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI601100
name: _AI601100_1_m
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_74f2de65_9c86_494f_9fb8_a40496a9fda9
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
name: MAN2B1
is: O00754
type: Species
is encoded by: hsa:4125
is: SBO:0000252
initial amount: NaN

metaM pmtcoa r
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
constant: false
type: Species
initial concentration: 1.0
is: HMDB01338
is: CHEBI:3454
is: C00154
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_db38d48e_34e7_4f6d_8ef4_29814563acde
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4881
is: P16066
boundary condition: true
name: NPR1
type: Species
constant: false
is: SBO:0000252

metaM mem2emgacpail hs r
initial amount: NaN
constant: false
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol (M4B)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: HMDB03125
type: Species
is: CHEBI:16240
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_5de24c40_762d_4eca_92e3_eb3dc33843ab
name: ADH1C
is encoded by: hsa:126
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: P00326
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r2021
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ppa c
is: HMDB00237
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:17272
name: propionate
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

metaR PNTEH
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
kinetic law: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.92
modifier: MODEL1310110028#
fast: false
reversible: false
name: Hydrolase Class ( RXN R02973)
is described by: ECO:0000269
type: Reaction

metaM dgchol c
is: CHEBI:36252
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00637
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate

metaR ARACHDt2
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
fast: false
reactant: MODEL1310110028#
reversible: true

metaM tetpent3coa c
name: tetracosapentaenoyl coenzyme A, n-3
boundary condition: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
constant: false
is: SBO:0000247
has only substance units: false
is: C16167
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_860e63cd_6efd_4be8_acea_70f861e15083
initial amount: NaN
constant: false
is: Q9UJM8
has only substance units: false
is encoded by: hsa:54363
is: SBO:0000252
boundary condition: true
type: Species
name: HAO1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_deba934c_d6f2_4b40_855a_d7457c5eebc5
is: SBO:0000252
constant: false
is encoded by: hsa:6487
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q11203
name: ST3GAL3
type: Species
initial concentration: NaN

metaR G14T8g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110028#
reactant: MODEL1310110028#

metaR MANtg
product: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000185
type: Reaction
reversible: false
name: mannose efflux from Golgi apparatus
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

metaR LGNCCOAtx
reactant: MODEL1310110028#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_e548c7f2_d20a_4166_bf94_db56696f1e67
name: HK2
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3099
is: P52789
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_94642ea5_6dc4_4dc0_8272_ecd80f9d4224
type: Species
is: SBO:0000252
initial amount: NaN
name: COX2
has only substance units: false
is: Q7GXZ8
initial concentration: NaN
constant: false
is encoded by: hsa:4513
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_bb1ac689_d108_4995_8a87_df07d938b342
has only substance units: false
is encoded by: hsa:2590
name: GALNT2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: Q10471
constant: false

metaM 6a2ohxnt x
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: HMDB12151
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
initial amount: NaN
is: SBO:0000247
name: 6-amino-2-oxohexanoic acid
is: CHEBI:17534
has only substance units: false

metaM cs a deg1 l
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01354
constant: false
is: CHEBI:57455
type: Species
boundary condition: false

metaR DHFR
kinetic law: MODEL1310110028#
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
product: MODEL1310110028#
name: dihydrofolate reductase
is described by: ECO:0000254

metaM ipdp c
initial amount: NaN
type: Species
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
has only substance units: false
constant: false
is: CHEBI:128769
initial concentration: 1.0
boundary condition: false
is: HMDB01347
name: Isopentenyl diphosphate
is: SBO:0000247
is: C00129

metaR ATPtx
fast: false
product: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is described by: ECO:0000000
name: ATP transporter, peroxisomal
reactant: MODEL1310110028#

metaM dcacoa m
name: Decanoyl-CoA (n-C10:0CoA)
is: HMDB06404
is: SBO:0000247
is: C05274
is: CHEBI:61430
boundary condition: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
has only substance units: false

metaM ksii core2 deg6 l
notes: FORMULA: C44H72N4O33SX CHARGE: -1
boundary condition: false
is: CHEBI:12936
is: SBO:0000247
has only substance units: false
is: HMDB00143
initial concentration: 1.0
constant: false
type: Species
name: keratan sulfate II (core 2-linked), degradation product 6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_8914cbd0_ea43_4675_873a_2500b002d3d0
initial concentration: NaN
is encoded by: hsa:771
is: O43570
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: CA12
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_02da59d2_eb70_4461_96fb_e7503c2794a7
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:7841
is: F5H6D0
name: MOGS
has only substance units: false
initial concentration: NaN

metaM C05965 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: CHEBI:57444
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: HMDB04243
name: 12(S)-HPETE(1-)

metaM T antigen g
name: T antigen (core 1)
initial amount: NaN
is: CHEBI:22783
notes: FORMULA: C14H24NO10X CHARGE: 0
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR TETHEX3COAtx
product: MODEL1310110028#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reactant: MODEL1310110028#

metaR DIDPtn
fast: false
reversible: true
name: dIDP nuclear transport
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#

metaR r1610
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR C81CRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaM sebcoa x
name: sebacoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
constant: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false

metaM 2oxoadp m
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: CHEBI:57499
constant: false
is: SBO:0000247
name: 2-oxoadipate(2-)
is: HMDB00225
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_d005a334_03cf_4368_b5e2_1eba5958b6f2
initial concentration: NaN
is: O00764
name: PDXK
initial amount: NaN
has only substance units: false
is encoded by: hsa:8566
constant: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_6b94eb81_add1_465e_a784_8fb62c3252d5
initial amount: NaN
boundary condition: true
has only substance units: false
name: VNN3:VNN2:VNN1
is: SBO:0000297
constant: false
initial concentration: NaN
is encoded by: hsa:55350
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_8df6fde8_7439_465b_9f37_0f9e0fec6948
is encoded by: hsa:5152
name: PDE9A
initial amount: NaN
has only substance units: false
boundary condition: true
is: O76083
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_25c87673_bc56_41cd_8089_f0555c40c851
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:4707
name: NDUFB1
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: O75438

metaR UMPK6
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dCTP)
is: SBO:0000176
reactant: MODEL1310110028#
fast: false
reversible: true

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR FAOXC141C121m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_7ea6530e_c23f_404a_b09d_97fa5afdf022
is: Q92523
initial concentration: NaN
is encoded by: hsa:1375
has only substance units: false
name: CPT1B
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaR TCHOLAte
name: bile acid intracellular transport
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
fast: false
is: SBO:0000185
type: Reaction

metaR LNLNCGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110028#
name: fatty acid transport via diffusion
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_72ff1004_e2c2_4a1e_9265_f530c683a840
is encoded by: hsa:3098
name: HK1
is: B3KXY9
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_44562135_c59f_40f4_baf2_90a201577400
boundary condition: true
is: P30613
type: Species
is: SBO:0000252
is encoded by: hsa:5313
constant: false
name: PKLR
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR C204CRNt
name: arachidonic acid transport into the mitochondria
type: Reaction
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport

metaM estradiol c
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16469
initial amount: NaN
initial concentration: 1.0
name: estradiol
has only substance units: false
type: Species
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
is: HMDB00151

http://identifiers.org/biomodels.db/MODEL1310110028#_1fc28c78_446a_47d8_a7ad_92cbd39f87e1
is encoded by: hsa:7001
is: P32119
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: PRDX2
initial concentration: NaN

metaR UMPK7
type: Reaction
fast: false
product: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000269
reversible: true
name: UMP kinase (dGTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110028#_676a7590_0c26_428d_9e36_2cb0ddd4f85e
has only substance units: false
is: B3KN25
is encoded by: hsa:10390
name: CEPT1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

metaM ps hs c
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
is: CHEBI:18303
boundary condition: false
name: ps_hs[c]
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN

metaR ILEt5m
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Isoleucine mitochondrial transport
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_704c3783_4be6_49ef_811f_809b8823ac43
is encoded by: hsa:54965
boundary condition: true
name: PIGX
initial amount: NaN
is: Q8TBF5
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaR GLXtp
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110028#
name: glyoxylate transport, peroxisomal

metaM 34dhoxmand c
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: CHEBI:27637
constant: false
type: Species
is: SBO:0000247
is: HMDB01866
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 3,4-Dihydroxymandelate

metaR AG13T9g
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reversible: false
modifier: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110028#
type: Reaction

metaR C60CPT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
reactant: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110028#
reversible: true
is described by: ECO:0000134
product: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_2f28cf7b_4980_486d_94e6_3c290d68d0df
initial concentration: NaN
type: Species
boundary condition: true
name: ST6GALNAC1
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9NSC7
has only substance units: false
is encoded by: hsa:55808

http://identifiers.org/biomodels.db/MODEL1310110028#_ccb8598c_ec41_478f_bb10_262d54a436ff
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4696
name: NDUFA3
type: Species
has only substance units: false
is: O95167
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_549fb5cb_d385_4fd2_8ed0_162c1a01a3e2
is encoded by: hsa:6173
boundary condition: true
is: P83881
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: RPL36A
initial amount: NaN
is: SBO:0000252

metaM dgchol e
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: glycochenodeoxycholate
has only substance units: false
is: HMDB00637
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_7c6a47b5_9163_4c62_a22c_1050ecf9ae32
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:2799
is: Q7Z3X3
has only substance units: false
name: GNS
constant: false

metaM dadp c
is: C00206
name: dADP
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57667
is: HMDB01508
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaM dsmsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
has only substance units: false
initial concentration: 1.0
is: CHEBI:17737
is: HMDB02719
name: desmosterol
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

metaR IDOAASE3ly
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
is described by: ECO:0000000
name: alpha-L-iduronidase, lysosomal
reversible: false
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

metaM dcsptn1crn m
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06321
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false

metaR C161CRNt
reversible: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
name: C161 transport into the mitochondria
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM g3m8mpdol U r
initial concentration: 1.0
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
constant: false
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
has only substance units: false
is: C05873
initial amount: NaN
type: Species
boundary condition: false

metaR TETPENT6t
reversible: true
kinetic law: MODEL1310110028#
name: fatty acid transport via diffusion
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction

metaR GAPD
is version of: http://identifiers.org/ec-code/1.2.1.12
product: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000134
name: glyceraldehyde-3-phosphate dehydrogenase

metaM ps hs e
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species
is: CHEBI:18303
initial concentration: 1.0
name: phosphatidylserine
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247

metaR DCSPTN1CPT2
name: carnitine transferase
is: SBO:0000176
reactant: MODEL1310110028#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false

metaM mescon m
initial amount: NaN
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: HMDB00749
has only substance units: false
boundary condition: false
name: Mesaconate
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:36986
constant: false

metaR r0027
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000176
reversible: true
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.14.13.39
kinetic law: MODEL1310110028#
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_77322b6e_b203_414c_85da_661c6d7484e0
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P18545
is encoded by: hsa:5148
type: Species
name: PDE6G
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_00413b4a_f4df_40d6_a3da_fe5e64f3f679
boundary condition: true
is: P00558
constant: false
is encoded by: hsa:5230
name: PGK1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_49c2ed18_baeb_43f6_8524_f12954678193
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
name: ACAA2
is: P42765
is encoded by: hsa:10449
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_815fcaae_b771_4185_8902_737101cef390
initial amount: NaN
type: Species
name: CHST6
is: SBO:0000252
has only substance units: false
is: Q9GZX3
constant: false
is encoded by: hsa:4166
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_5af89fd6_0322_4bef_9c78_4457d4d68a7f
constant: false
is: Q76EJ3
is encoded by: hsa:11046
initial concentration: NaN
type: Species
name: SLC35D2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_72e1ddf6_51dc_47b6_b910_717b48772f4c
constant: false
name: CS
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1431

http://identifiers.org/biomodels.db/MODEL1310110028#_521a9efe_8382_4e62_80d8_9110cdea010e
is: Q9UJ70
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55577
has only substance units: false
constant: false
name: NAGK

http://identifiers.org/biomodels.db/MODEL1310110028#_ee746837_37c0_489e_b861_22118d456606
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:8654
type: Species
is: SBO:0000252
name: PDE5A
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_5e517972_8155_4591_a672_2364233c287c
boundary condition: true
name: SLC22A3
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is: Q5SYN6
has only substance units: false
is encoded by: hsa:6581
type: Species

metaR DCSPTN1CPT1
is: SBO:0000176
reactant: MODEL1310110028#
product: MODEL1310110028#
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
modifier: MODEL1310110028#
reversible: false
fast: false

metaR r0022
reversible: true
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.8.1.7

metaM ddcacoa c
is: CHEBI:57375
initial amount: NaN
is: HMDB03571
boundary condition: false
has only substance units: false
is: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_416d89a4_43e7_475b_a462_183d61725565
is encoded by: hsa:5145
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: PDE6A
constant: false
is: P16499

metaR FAOXC205C184x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaR FAOXC102C103x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR TTDCAtr
fast: false
name: tetradecanoate (transport)
kinetic law: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
product: MODEL1310110028#

metaR NDPK2m
modifier: MODEL1310110028#
name: nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
reactant: MODEL1310110028#
is described by: ECO:0000254
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reversible: true
fast: false
is: SBO:0000176

metaM tetd7ecoa m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
type: Species
name: 7-tetradecenoylcoa
initial amount: NaN
is: HMDB13109
boundary condition: false
constant: false
has only substance units: false

metaR ASNtm
is: SBO:0000185
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
name: L-asparagine transport, mitochondrial
type: Reaction
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM hmgcoa m
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
boundary condition: false
has only substance units: false
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

metaR ADCim
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
kinetic law: MODEL1310110028#
type: Reaction
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000000
reversible: false

metaM HC02187 c
boundary condition: false
initial concentration: 1.0
is: CHEBI:28774
type: Species
constant: false
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM retn r
constant: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
type: Species
is: HMDB01852
has only substance units: false
is: SBO:0000247
name: all-trans-retinoate
boundary condition: false
is: CHEBI:35291
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c6c01d3c_08f7_40b2_a731_63bd4ef8dee5
has only substance units: false
name: _AL050025_1_c
type: Species
is encoded by: hsa:AL050025
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaR r0021
fast: false
reversible: true
modifier: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110028#_62709bae_55f7_4016_873d_243318ca84d5
constant: false
is encoded by: hsa:26
has only substance units: false
initial concentration: NaN
name: ABP1
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: P19801

http://identifiers.org/biomodels.db/MODEL1310110028#_38c53930_1fa3_48bb_837e_1efe6421027c
is encoded by: hsa:8034
type: Species
is: P16260
name: SLC25A16
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR ACNAMtn
reversible: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110028#
name: N-acetylneuraminate nuclear import
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_2e899121_d988_4fce_976a_aff270095156
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:6647
name: SOD1
initial amount: NaN
is: SBO:0000252
is: P00441
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a0068b99_a430_4e02_9e71_3f4232d97353
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:11227
has only substance units: false
name: GALNT5
initial concentration: NaN
boundary condition: true
is: A5PKZ1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_9105b95e_352c_4c35_9c62_81650e692840
is: Q9NR45
name: NANS
is encoded by: hsa:54187
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_df8dca57_67a0_4039_a141_b4ab25eade42
is: Q8IV97
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: SLC7A5
initial concentration: NaN
constant: false
is encoded by: hsa:8140

metaR PE HSter
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
name: phosphatidylethanolamine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:

metaM CE5788 e
name: kinetensin 1-7
type: Species
constant: false
boundary condition: false
is: CHEBI:27485
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB02710

metaR GLXtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
type: Reaction
reactant: MODEL1310110028#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: glyoxylate transport, mitochondrial

metaR BDMT U
fast: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.142

http://identifiers.org/biomodels.db/MODEL1310110028#_5f445e17_820a_4d37_a9f0_6d3b1f38fe2a
has only substance units: false
is: SBO:0000252
constant: false
is: H0UI06
initial amount: NaN
name: COX7A2
initial concentration: NaN
type: Species
is encoded by: hsa:1347
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_52c0b34b_5c10_4f28_b8c1_51052140ee80
is: Q9H999
name: PANK3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:79646
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_d51b4889_f715_45fc_8d55_1d5fb95ba60e
name: PIGU
is: Q9H490
is: SBO:0000252
is encoded by: hsa:128869
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM lnlccrn c
type: Species
is: SBO:0000247
name: Linoleyl carnitine
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
is: HMDB06469
initial concentration: 1.0

metaM lnlncgcoa c
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
is: SBO:0000247
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
constant: false
is: CHEBI:57363

http://identifiers.org/biomodels.db/MODEL1310110028#_404d2c20_ee1c_48f8_92a1_36914b0f7651
initial amount: NaN
has only substance units: false
is encoded by: hsa:5153
initial concentration: NaN
is: Q7Z364
name: PDE1B
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR AG13T14g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
type: Reaction
reversible: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000

metaM tddedicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280771
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: trans3,6dodecadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110028#_51ccc542_595e_42e2_8f0e_30943261546e
has only substance units: false
name: _AA629629_1_m
boundary condition: true
is encoded by: hsa:AA629629
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_9b764814_4184_48c5_baed_b3e7d25769ee
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: Q8N4Q0
is: SBO:0000252
constant: false
name: ZADH2
initial concentration: NaN
is encoded by: hsa:284273

metaR NRPPHRt4 2 r
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
name: Norepinephrine reversible transport in via sodium symport (1:2)
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_6075a3fe_b195_4646_abcd_b1b4e1fb1e63
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: PDE9A
boundary condition: true
is encoded by: hsa:5152
constant: false

metaR ARABR
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
modifier: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
name: arabinose reductase

metaM hxcoa c
has only substance units: false
is: SBO:0000247
is: HMDB13130
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species

metaM estradiol e
type: Species
is: HMDB00151
is: CHEBI:16469
initial amount: NaN
constant: false
has only substance units: false
name: estradiol
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_f6dc9696_78ee_4226_a028_5f6a6abc18c1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4522
initial amount: NaN
constant: false
name: MTHFD1
is: P11586
boundary condition: true

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

metaR FRUt4
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110028#
name: D-fructose transport via sodium cotransport
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110028#

metaR DCSPTN1COAtx
reversible: true
is: SBO:0000185
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
is described by: ECO:0000000
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false

metaM 5aizc c
boundary condition: false
type: Species
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB06273
is: CHEBI:58564
is: C04751
initial amount: NaN
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

metaR NDPK2n
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is: SBO:0000176

metaM HC01410 m
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
is: CHEBI:28706
type: Species
name: (2E)-Hexenoyl-CoA
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

metaM tdec4ecoa m
is: SBO:0000247
name: trans4decenoylcoa
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
is: HMDB00792
is: C08277
constant: false
boundary condition: false

metaM 4abutn m
has only substance units: false
is: CHEBI:58264
type: Species
constant: false
initial concentration: 1.0
name: 4-ammoniobutanal
is: SBO:0000247
initial amount: NaN
is: HMDB01080
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
boundary condition: false

metaM ksi pre1 g
notes: FORMULA: C79H129N5O57X CHARGE: -1
initial concentration: 1.0
is: C00130
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: HMDB00175
has only substance units: false
boundary condition: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 1

http://identifiers.org/biomodels.db/MODEL1310110028#_d733fbdc_0c7d_47b4_817c_21031ba60d1a
is encoded by: hsa:50814
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q15738
name: NSDHL
type: Species
is: SBO:0000252

metaR CRNtim
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
name: L-carnitine transport out of mitochondria via diffusion
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_1e38bfa5_1590_499d_88b0_2d940e79677a
type: Species
constant: false
initial concentration: NaN
name: _AI222095_1_m
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI222095

metaR r2514
type: Reaction
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reversible: true
is: SBO:0000185

metaM gthrd r
is: CHEBI:57925
is: HMDB00125
name: glutathionate(1-)
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species

metaM ksi deg1 e
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
name: keratan sulfate I, degradation product 1
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17268
constant: false
initial concentration: 1.0
type: Species
is: HMDB00211
has only substance units: false

metaR GLCNACASE4ly
modifier: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
name: alpha-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.50

metaR GASNASE2ly
name: glycosylasparaginase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176
fast: false
reactant: MODEL1310110028#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_6ef937e1_5abf_4e0e_b926_ba2c57b8d6ec
is encoded by: hsa:27068
name: PPA2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
constant: false

metaM ksii core2 pre4 g
is: SBO:0000247
has only substance units: false
is: CHEBI:58053
initial amount: NaN
notes: FORMULA: C53H86N4O38X CHARGE: -1
initial concentration: 1.0
is: HMDB00175
is: C00130
name: keratan sulfate II biosynthesis, precursor 4
type: Species
boundary condition: false
constant: false

metaR RE3273C
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
type: Reaction
product: MODEL1310110028#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
name: RE3273
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_9dd8678e_da3d_429a_85d0_f1d6ec395dba
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: FOLR3
is: Q05C14
is encoded by: hsa:2352
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_4fccdfeb_37b4_487e_aec0_88de57efe29d
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:30
is: Q96CA6
name: ACAA1
constant: false
type: Species
is: SBO:0000252
boundary condition: true

metaM n2m2nmn l
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C50H84N4O36 CHARGE: 0
constant: false
is: SBO:0000247
is: CHEBI:16680
is: HMDB00939
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
initial amount: NaN
initial concentration: 1.0

metaM dheas c
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
is: HMDB01032
boundary condition: false
is: CHEBI:57905
type: Species
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN

metaR SERGLYexR
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110028#
name: L-Serine/Glycine reversible exchange
reversible: true
reactant: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
fast: false

metaM Lcystin c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00192
constant: false
has only substance units: false
name: L-cystine
boundary condition: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
type: Species

metaR LEUKTRB4t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: leukotriene B4 transport
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is: SBO:0000185

metaM ksii core2 pre7 g
is: HMDB00175
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 7
is: C00130
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C67H108N5O51SX CHARGE: -2
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_13c3e849_a141_4eff_b648_717e307f8424
type: Species
is encoded by: hsa:6483
constant: false
is: Q16842
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ST3GAL2
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_ca6da619_589b_4956_82d9_d9dbb1f817d2
has only substance units: false
is encoded by: hsa:100128062
is: SBO:0000252
boundary condition: true
name: _100128062_1_m
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaM dlnlcgcoa m
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
constant: false
initial amount: NaN
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
has only substance units: false
type: Species
is: CHEBI:27979
initial concentration: 1.0
boundary condition: false

metaR r2516
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110028#
is: SBO:0000185
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_93d95ef8_1b43_4806_b05e_69acbff72e26
boundary condition: true
constant: false
type: Species
is: P30049
is encoded by: hsa:513
has only substance units: false
name: ATP5D
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR DDPGAm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction

metaM dmhptcrn c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
name: 2,6 dimethylheptanoyl carnitine
type: Species
initial amount: NaN
boundary condition: false
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3

metaR r2517
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
type: Reaction
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

metaR IVCOAACBP
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Isovaleryl-CoA from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_7af73d56_3377_4752_9a71_17e381b1cf30
is: O43280
type: Species
name: TREH
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:11181
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaM HC01444 e
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
boundary condition: false
name: Galactosylglycerol
is: CHEBI:15754
initial amount: NaN
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_bcef55ee_9bfb_415b_974f_36c17f309540
is: SBO:0000252
is: Q6FGA0
has only substance units: false
is encoded by: hsa:9167
boundary condition: true
type: Species
constant: false
name: COX7A2L
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_2e6527b3_7b2c_4000_9785_2c8c79f44c97
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
type: Species
is: SBO:0000297
has only substance units: false
boundary condition: true
initial amount: NaN
has part: P56134
initial concentration: NaN
is encoded by: hsa:9551

metaR ALCD21 D
fast: false
is described by: ECO:0000304
name: alcohol dehydrogenase (D-1,2-propanediol)
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.99.24

http://identifiers.org/biomodels.db/MODEL1310110028#_02170c2c_cac7_49b2_90d4_fc93dfae155f
name: _AI091231_1_c
is encoded by: hsa:AI091231
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM hdcea r
constant: false
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229
name: palmitoleate
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:32372
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_9b2d0466_4c19_425c_b14b_d83265f0a414
constant: false
is encoded by: hsa:51227
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PIGP
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_8f4c62de_fd3c_4fa9_83b2_d04f4cf66554
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _H53099_1_m
initial amount: NaN
is encoded by: hsa:H53099
is: SBO:0000252
type: Species

metaM 3oddcoa x
is: CHEBI:27868
is: SBO:0000247
type: Species
initial amount: NaN
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
is: HMDB03937
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263

metaM ksi pre29 g
is: CHEBI:28067
constant: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 29
initial amount: NaN

metaR G14T11g
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110028#
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false

metaM Lcystin e
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00192
initial concentration: 1.0
name: L-cystine
has only substance units: false
type: Species
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: CHEBI:16283
initial amount: NaN

metaM ksi pre3 g
type: Species
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 3
notes: FORMULA: C93H152N6O67X CHARGE: -1
initial concentration: 1.0
is: CHEBI:58053
has only substance units: false
is: C00130
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

metaR FORMCOAtx
name: formyl coa transport
type: Reaction
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
fast: false
reactant: MODEL1310110028#
is: SBO:0000185

metaR ALCD21 L
is described by: ECO:0000304
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.99.24
kinetic law: MODEL1310110028#
reversible: false
name: alcohol dehydrogenase (L-1,2-propanediol)
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110028#
product: MODEL1310110028#

metaM dmhptcrn e
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 2,6 dimethylheptanoyl carnitine
has only substance units: false
is: HMDB06320
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3

metaM hs deg23 l
type: Species
has only substance units: false
constant: false
is: CHEBI:21338
boundary condition: false
initial concentration: 1.0
is: HMDB02704
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C31H49NO29S CHARGE: -2
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose

metaR SUBEACTD
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_a8b2e58e_0811_4ae7_a949_c921fd41977b
initial amount: NaN
is encoded by: hsa:AI631997
has only substance units: false
constant: false
boundary condition: true
name: _AI631997_1_m
type: Species
is: SBO:0000252
initial concentration: NaN

metaM tre e
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
type: Species
boundary condition: false
name: Trehalose
has only substance units: false
initial concentration: 1.0
is: C01083
initial amount: NaN
is: HMDB00975
is: CHEBI:16551
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_5849557b_bad2_4bfc_aa3b_43fc99058810
name: GLUD2
is encoded by: hsa:2747
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: P49448
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_12d2a94a_445c_412b_ab2f_767c9400b3ea
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
name: GSTZ1
is encoded by: hsa:2954
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_e35eb542_be5a_4321_8756_88562f0216d8
initial concentration: NaN
is encoded by: hsa:222
is: P48448
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
name: ALDH3B2

http://identifiers.org/biomodels.db/MODEL1310110028#_085199a8_8dd2_4c17_9867_4edc8f87b650
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: Q14432
name: PDE3A
constant: false
initial amount: NaN
is encoded by: hsa:5139
initial concentration: NaN

metaR HAS1
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
name: hyaluronan synthase
is described by: ECO:0000269
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.212
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD

metaM dolp L c
name: dolichyl phosphate(2-)
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
boundary condition: false
initial concentration: 1.0

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaM chol c
is: SBO:0000247
is: C00114
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:15354
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00097
name: Choline
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaM cs e deg5 l
has only substance units: false
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
is: HMDB00868
initial amount: NaN
is: CHEBI:57737
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C31H47NO35S3 CHARGE: -4

metaM citr L e
constant: false
name: citr_L[e]
initial amount: NaN
is: CHEBI:16349
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00904
type: Species

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR PSDm hs
fast: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.1.1.65
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
name: Phosphatidylserine decarboxylase
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ

metaM docohexcoa m
name: 2,4,7,10,13,16-docosahexenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_6c9c4298_6840_49e3_b420_3c04257c4b59
constant: false
is encoded by: hsa:226
type: Species
has only substance units: false
name: ALDOA
boundary condition: true
is: SBO:0000252
is: P04075
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_3c239396_79ed_4aee_8b67_b17597bb679a
is encoded by: hsa:10455
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
name: ECI2
is: SBO:0000252
initial concentration: NaN
is: O75521

metaR RE2799C
type: Reaction
is: SBO:0000176
reversible: true
name: RE2799
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_0249ab03_f972_41e1_9292_fab60dba6982
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ARSB
has only substance units: false
is encoded by: hsa:411
is: P15848

metaM ppi c
boundary condition: false
is: SBO:0000247
is: C00013
is: CHEBI:0
constant: false
name: Diphosphate
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00250

metaM acmana e
type: Species
is: HMDB01129
has only substance units: false
constant: false
name: N-acetyl-D-mannosamine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
is: SBO:0000247
is: CHEBI:17122

http://identifiers.org/biomodels.db/MODEL1310110028#_de2d889b_87db_4eb9_b159_e4e3edd20b88
name: PDE9A
boundary condition: true
is encoded by: hsa:5152
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_c469acc0_c97d_428a_8aea_ac4e06c14425
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:1854
boundary condition: true
type: Species
is: SBO:0000252
name: DUT
is: P33316

http://identifiers.org/biomodels.db/MODEL1310110028#_9b36bdcd_06c6_4951_8617_71266f550847
name: ENTPD2
is encoded by: hsa:954
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: Q5SPY7
is: SBO:0000252

metaM asp L c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: L-aspartate(1-)
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
type: Species
constant: false
is: CHEBI:29991
is: HMDB00191
initial amount: NaN

metaM 3hexdcrn c
initial concentration: 1.0
has only substance units: false
name: 3-hydroxyhexadecanoylcarnitine
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB13336
constant: false
notes: FORMULA: C23H45NO5 CHARGE: 0

metaM glyclt x
name: glycolate
is: HMDB00115
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial concentration: 1.0
has only substance units: false
is: CHEBI:29805

metaR r0630
fast: false
modifier: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110028#
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.1
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM asp L e
constant: false
is: HMDB00191
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
has only substance units: false
boundary condition: false
is: CHEBI:29991
initial amount: NaN
name: L-aspartate(1-)
is: SBO:0000247
initial concentration: 1.0

metaM HC00900 c
is: CHEBI:30860
constant: false
name: Methylmalonate
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_7ccfdfef_0a36_4a02_8797_36f664f1b5b3
name: AMY1B
has only substance units: false
constant: false
type: Species
boundary condition: true
is: P04745
is encoded by: hsa:277
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_26707507_b424_419c_af09_a605ac77c318
is: E9KL42
initial concentration: NaN
constant: false
is encoded by: hsa:641371
initial amount: NaN
is: SBO:0000252
name: ACOT1
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_f00a54b7_7294_4876_9f65_274765daa568
constant: false
is: E9PAK4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC5A9
type: Species
is encoded by: hsa:200010
has only substance units: false

metaR C6CRNtcx
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaM citr L c
is: CHEBI:16349
name: L-citrulline
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00904
type: Species
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
has only substance units: false

metaM air c
boundary condition: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
type: Species
is: HMDB01235
initial amount: NaN
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:58592
is: C03373
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_1fb2c737_ce95_402d_b4f9_f04e132d179a
initial amount: NaN
constant: false
is encoded by: hsa:80347
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q13057
has only substance units: false
name: COASY
boundary condition: true

metaR r2137
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
type: Reaction
modifier: MODEL1310110028#

metaR PPItr
reactant: MODEL1310110028#
type: Reaction
name: Diphosphate transporter, endoplasmic reticulum
product: MODEL1310110028#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: true

metaM 4abutn e
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
has only substance units: false
is: HMDB01080
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 4-ammoniobutanal
constant: false
is: CHEBI:58264
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c0900181_b6b2_4c4a_945b_5b8753c6fb42
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: PRPS1L1
is encoded by: hsa:221823
is: SBO:0000252

metaM CE2420 m
initial concentration: 1.0
type: Species
is: HMDB11123
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: SBO:0000247
is: CHEBI:28387
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
constant: false

metaR FACOAL161
fast: false
reversible: true
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: fatty-acid--CoA ligase (hexadecenoate)

metaM acmana c
is: HMDB01129
boundary condition: false
is: CHEBI:17122
initial amount: NaN
initial concentration: 1.0
name: N-acetyl-D-mannosamine
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
has only substance units: false
constant: false
is: SBO:0000247

metaR RE3005M
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
name: RE3005

metaM ppi e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
is: CHEBI:33019
is: HMDB00250
constant: false
has only substance units: false
is: C00013
is: SBO:0000247
name: Diphosphate
type: Species

metaR AKR1D
reversible: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
reactant: MODEL1310110028#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.3
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110028#
modifier: MODEL1310110028#

metaR r0784
reversible: true
is described by: ECO:0000000
product: MODEL1310110028#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction

metaM leuleu c
boundary condition: false
notes: FORMULA: C12H24N2O3 CHARGE: 0
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Leucylleucine
type: Species
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
constant: false

metaR GTHOm
name: glutathione oxidoreductase
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.8.1.7
kinetic law: MODEL1310110028#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2

metaR H2O2tn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#
name: hydrogen peroxide nuclear transport
reversible: true
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000

metaR NDPK10
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dIDP)
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110028#
type: Reaction
fast: false
kinetic law: MODEL1310110028#

metaM 3snpyr m
constant: false
is: CHEBI:1665
initial amount: NaN
type: Species
name: 3-Sulfinopyruvate
is: SBO:0000247
boundary condition: false
is: HMDB02332
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_defd28ac_7308_49f3_ba98_31243e1a676b
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: FASN
type: Species
constant: false
is encoded by: hsa:2194
is: P49327
initial concentration: NaN
boundary condition: true

metaR r2136
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
type: Reaction
reversible: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
fast: false

metaR GALASE10ly
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110028#
name: beta-galactosidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110028#
reversible: false
is: SBO:0000176

metaM ksi pre20 g
boundary condition: false
has only substance units: false
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 20
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C171H274N12O140S6X CHARGE: -7

http://identifiers.org/biomodels.db/MODEL1310110028#_efa4b2d9_6f64_4ab1_8af0_c8b1e2bc6fa1
has part: Q9NY65
type: Species
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:1962
name: EHHADH:ACAA1:ACOX1
is: SBO:0000297
initial amount: NaN

metaM ksi deg26 l
is: SBO:0000247
boundary condition: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
type: Species
is: CHEBI:58343
is: HMDB00061
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: keratan sulfate I, degradation product 26
constant: false

metaM 3hexdcrn e
constant: false
notes: FORMULA: C23H45NO5 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxyhexadecanoylcarnitine
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB13336

http://identifiers.org/biomodels.db/MODEL1310110028#_73a1982e_ed89_46eb_ada4_42bbad7ac41e
is: P53794
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: SLC5A3
is encoded by: hsa:6526
has only substance units: false
constant: false
type: Species
boundary condition: true

metaM dolp L r
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
constant: false
is: CHEBI:57683
type: Species
name: dolichyl phosphate(2-)
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR GLCGLUT2
notes: GENE_ASSOCIATION: (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 71-74 NOTES:GLUT-2 can also move to the apical surface and aid in glucose import into the cell under fully fed state (PMID: 17786952)
name: Transport of glucose into the portal blood
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000134
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_3ec7edc0_5bf9_4aba_852e_93b4750eda60
initial concentration: NaN
is encoded by: hsa:23657
name: SLC7A11
constant: false
type: Species
is: SBO:0000252
is: Q9UPY5
has only substance units: false
boundary condition: true
initial amount: NaN

metaM ocdcea e
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00207
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
is: CHEBI:0
is: C00712
name: octadecenoate (n-C18:1)

metaM pristcoa x
initial amount: NaN
is: CHEBI:51341
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
name: pristanoyl coa
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
has only substance units: false

metaR HAS2
modifier: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.212
is described by: ECO:0000269
type: Reaction
fast: false
name: hyaluronan synthase
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
reversible: false
is: SBO:0000185

metaM 2amac c
initial amount: NaN
name: 2-aminoacrylic acid
is: SBO:0000247
is: HMDB03609
is: CHEBI:17123
boundary condition: false
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

metaR H2O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110028#
reversible: true
name: hydrogen peroxide peroxisomal transport via diffusion
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000

metaM 5forthf c
initial amount: NaN
is: HMDB01534
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57456
is: C00664
is: SBO:0000247
name: 5-Formiminotetrahydrofolate
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
type: Species
constant: false

metaR NACHEX10ly
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110028#
product: MODEL1310110028#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110028#

metaM chol e
is: CHEBI:15354
name: Choline
is: C00114
boundary condition: false
constant: false
is: HMDB00097
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaM na1 c
is: CHEBI:4541
boundary condition: false
is: HMDB00588
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C01330
type: Species
notes: FORMULA: Na CHARGE: 1
has only substance units: false
name: Sodium

metaR FAOXC6C4x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

metaR BILIRUBt2
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
name: bilirubin transport via bicarbonate countertransport
fast: false
reactant: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000185

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM dlnlcgcoa c
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27979
initial amount: NaN
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
has only substance units: false
constant: false
name: dihomo-gamma-linolenyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110028#_8e953c7a_cec2_4cb6_b9ae_73ccd2ef9dca
is: A8K092
name: ATP5A1
type: Species
is encoded by: hsa:498
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_38669aac_731c_4658_b389_0614f15d54e6
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110028#_fcfd44d3_89e5_49ae_8ef6_792b59e2eb12
is encoded by: hsa:58510
initial concentration: NaN
type: Species
initial amount: NaN
name: PRODH2
is: Q9UF12
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR LPCHOLt
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
name: lysophosphatidylcholine transport
reversible: true
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
type: Reaction

metaM dhdascb c
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:58070
initial concentration: 1.0
is: HMDB01264
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
constant: false
type: Species
has only substance units: false
name: dehydroascorbide(1-)

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR r0787
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.1
reversible: false
type: Reaction
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000176
fast: false
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_d12f1f77_b39a_4b81_a620_0cfe80dcb1b7
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:1339
initial concentration: NaN
is: Q02221
type: Species
boundary condition: true
name: COX6A2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_21cd5690_0dc3_495c_843e_17defa0be651
is: P00390
is: SBO:0000252
is encoded by: hsa:2936
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
name: GSR

metaM acgam1p c
name: N-Acetyl-D-glucosamine 1-phosphate
is: CHEBI:7125
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
boundary condition: false
is: HMDB01367
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

metaR biomass reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: false
is: SBO:0000185
is described by: ECO:0000134
name: biomass_reaction
fast: false
type: Reaction

metaR GALASE12ly
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
reversible: false
modifier: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM ksi pre7 g
name: keratan sulfate I biosynthesis, precursor 7
boundary condition: false
is: SBO:0000247
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: C00130
initial amount: NaN
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_d6c1429a_268c_45d9_bf66_e06650cb4f80
name: ST3GAL3
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6487
type: Species
initial amount: NaN
initial concentration: NaN
is: Q5T4W8
has only substance units: false
constant: false

metaR r2133
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110028#
type: Reaction
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_148ab7f9_000f_4c5b_a62b_9f44165d7f23
initial amount: NaN
is encoded by: hsa:11001
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O14975
constant: false
name: SLC27A2

metaM ocdcea c
is: CHEBI:0
is: C00712
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
initial amount: NaN
name: octadecenoate (n-C18:1)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_2f677042_fce4_499d_9d07_36733e21638b
type: Species
name: _W87865_1_c
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:W87865
is: SBO:0000252
constant: false
initial amount: NaN

metaR r2405
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110028#
is: SBO:0000185
type: Reaction
reversible: false
kinetic law: MODEL1310110028#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
fast: false
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_ea62e225_2674_4e67_a794_52afac1e98c2
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:622
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: BDH1

http://identifiers.org/biomodels.db/MODEL1310110028#_298e47a7_83bb_45ac_a842_eed39c892e33
type: Species
is encoded by: hsa:1635
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
name: DCTD
is: SBO:0000252
has only substance units: false
is: P32321

metaR r2347
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110028#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: Organic anion transporter 5 Utilized transport
reversible: true
product: MODEL1310110028#
is: SBO:0000185

metaR EX 3deccrn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaR r0780
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reversible: true
modifier: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR r2132
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#

metaM na1 e
is: HMDB00588
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: Na CHARGE: 1
type: Species
is: CHEBI:4541
is: SBO:0000247
boundary condition: false
is: C01330
name: Sodium
initial amount: NaN

metaR r2406
fast: false
type: Reaction
kinetic law: MODEL1310110028#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
product: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR DNDPt23m
fast: false
name: dTDP transport via dGTP antiport
product: MODEL1310110028#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaM 3octdectecoa m
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5280355
name: 3,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false

metaR r2346
fast: false
reversible: true
product: MODEL1310110028#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110028#

metaR ADPtx
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
name: ADP transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reversible: true
is described by: ECO:0000000
fast: false

metaR PPItx
name: Diphosphate transporter, peroxisome
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_0b4b0551_2103_41b7_a3b5_c82fac0dd4d8
name: AK2
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:204
type: Species
is: P54819
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_f1c83adc_9db4_4784_9a66_74ba4fcdd227
initial concentration: NaN
name: DDC
is: Q53Y41
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:1644
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_8fd20146_933b_4589_8419_858ddfdeff16
initial concentration: NaN
initial amount: NaN
name: SULT2A1
is: Q06520
boundary condition: true
is encoded by: hsa:6822
is: SBO:0000252
type: Species
constant: false
has only substance units: false

metaM udpglcur c
type: Species
is: HMDB00935
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
is: CHEBI:58052

metaM dhdascb e
name: dehydroascorbide(1-)
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58070
is: HMDB01264
boundary condition: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM CE5132 c
initial amount: NaN
type: Species
is: CHEBI:57923
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132

http://identifiers.org/biomodels.db/MODEL1310110028#_74d7613d_1fac_421b_b136_ac3333038d49
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA614647
initial amount: NaN
constant: false
name: _AA614647_1_c

metaR r0781
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000176

metaR RE3346M
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
reversible: true
name: RE3346
is described by: ECO:0000000

metaR r2131
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR S4TASE3ly
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: N-acetylgalactosamine-4-sulfatase, lysosomal

metaM 4abutn c
is: C00555
constant: false
initial amount: NaN
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 4-Aminobutanal
is: HMDB01080
type: Species
is: CHEBI:58264

http://identifiers.org/biomodels.db/MODEL1310110028#_22340f52_1109_483e_b117_a7c4b8d49619
has only substance units: false
initial concentration: NaN
has part: Q6IB04
has part: Q8TEQ8
constant: false
name: PIGF:PIGO
is encoded by: hsa:84720
type: Species
is encoded by: hsa:5281
initial amount: NaN
boundary condition: true
is: SBO:0000297

metaR RE1526M
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
reactant: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
name: RE1526

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaM leuleu e
constant: false
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/94244
initial concentration: 1.0
type: Species
name: Leucylleucine
has only substance units: false
boundary condition: false
notes: FORMULA: C12H24N2O3 CHARGE: 0

metaM 3ddecdicoa x
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: C05280
has only substance units: false
is: HMDB03952
is: SBO:0000247
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 3,6-dodecadienoylcoa

metaM dd5ecoa m
is: C01942
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB13028
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
constant: false
name: 5-dodecenoylcoa
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_f9b6d7f6_9d25_46c3_a4d9_9da633d1d47a
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: HSD3B1
initial amount: NaN
is encoded by: hsa:3283
is: P14060

metaM docohexcoa x
boundary condition: false
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
name: 2,4,7,10,13,16-docosahexenoylcoa
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
constant: false
initial amount: NaN

metaR D3AIBTm
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
is: SBO:0000176
type: Reaction
reactant: MODEL1310110028#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110028#_19a4f465_c15c_4720_bc83_308413b0cbdb
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:4708
name: NDUFB2
initial amount: NaN
constant: false
boundary condition: true
is: H7C5B8
has only substance units: false

metaR r2130
kinetic law: MODEL1310110028#
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a1a0084c_7592_4019_852c_e5f0867c6653
has only substance units: false
name: PKM2
is: SBO:0000252
is encoded by: hsa:5315
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: P14618
constant: false

metaR r2344
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110028#

metaM vitd3 c
is: CHEBI:28940
name: calciol
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: SBO:0000247
is: HMDB00876
initial concentration: 1.0
type: Species

metaR r2408
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
modifier: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
product: MODEL1310110028#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaR r0783
modifier: MODEL1310110028#
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
product: MODEL1310110028#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_f3ba78c3_22dc_463a_8dde_e28a4ba9c010
is encoded by: hsa:272
is: B7Z763
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: AMPD3
boundary condition: true

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_abf66f33_dcc4_4e02_96c2_00e72c0bbe57
boundary condition: true
name: HYALP1
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:26062
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_61d187d2_aae2_4acd_80f0_bd02d6464b0c
is: P19961
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:280
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: AMY2B

metaR r1716
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: false
type: Reaction
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_f6d40408_0e20_4d79_8f66_2a7efdb6edc2
name: SLC34A1
type: Species
boundary condition: true
is encoded by: hsa:6569
initial concentration: NaN
initial amount: NaN
is: Q7Z725
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_d50e57bf_9ef6_489b_ba5e_21e275b43f45
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: ADSL
initial amount: NaN
has only substance units: false
is encoded by: hsa:158
is: P30566

metaR UGT1A10r
type: Reaction
is described by: ECO:0000134
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is: SBO:0000176
fast: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
product: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.1.17

metaM occoa m
is: HMDB01070
is: C01944
initial concentration: 1.0
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
name: Octanoyl-CoA (n-C8:0CoA)

metaR RE3347C
name: RE3347
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaM hxan c
is: HMDB00157
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:17368
is: SBO:0000247
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
has only substance units: false
is: C00262
initial amount: NaN
name: Hypoxanthine

MODEL1310110028
species: metaM dhcholoylcoa x
reaction: metaR SUCCtp
reaction: metaR NDPK7n
species: metaM srtn c
species: metaM core2 g
reaction: metaR DURIPP
species: metaM sql r
species: metaM 4fumacac c
reaction: metaR FOAXC122C101x
species: metaM HC00460 c
species: metaM 3octdece1coa m
reaction: metaR CHATn
species: metaM sgalside hs g
species: metaM bhb c
reaction: metaR GLUDym
species: metaM glyc R m
reaction: metaR EX 5thf LPAREN e RPAREN
reaction: metaR r1291
species: metaM 1pyr5c c
reaction: metaR DECDICRNe
species: metaM octd11ecoa m
species: metaM Ssq23epx r
reaction: metaR r2095
reaction: metaR AHEXASEly
reaction: metaR FAOXC102C81x
reaction: metaR ACACT7p
species: metaM c226coa c
species: metaM dcacoa c
species: metaM zymstnl r
reaction: metaR r0633
species: metaM HC02205 e
reaction: metaR r0575
reaction: metaR SQLEr
reaction: metaR FAOXC161C141m
species: metaM stcoa c
reaction: metaR DNDPt28m
reaction: metaR ENGASEly
species: metaM ttdcrn c
reaction: metaR PPDOy
reaction: metaR FAOXC14C12m
reaction: metaR FAOXC81C61x
reaction: metaR ASCBt
species: metaM adrn c
species: metaM aacoa c
species: metaM 2dodtricoa x
reaction: metaR r1090
reaction: metaR GGH 7THFe
reaction: metaR CHOLESTle
reaction: metaR r0559
species: metaM q10 m
reaction: metaR r2376
species: metaM acac e
species: metaM ala B e
reaction: metaR AHCYStr
reaction: metaR EX akg LPAREN e RPAREN
reaction: metaR FAOXC61x
species: metaM sgalside hs l
species: metaM m8mpdol U r
species: metaM cholcoaone x
reaction: metaR FAOXC164C165x
reaction: metaR ALAGLNexR
species: metaM mthgxl e
reaction: metaR r0443
reaction: metaR GCC2cm
species: metaM prist c
species: metaM ksii core2 pre10 g
species: metaM L2aadp c
species: metaM ctdecdcoa m
species: metaM glyc c
reaction: metaR r2360
species: metaM HC02204 c
reaction: metaR RE0577C
species: metaM dec47dicoa x
species: metaM nrvnccoa x
reaction: metaR SUCCTD
species: metaM 2amac c
reaction: metaR GLNS
species: metaM leuktrC4 c
reaction: metaR KAS8
reaction: metaR MTHFCm

metaR r1459
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110028#
name: Transport reaction
fast: false
reversible: true

metaR r1564
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR MMSAD1m
kinetic law: MODEL1310110028#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
is version of: http://identifiers.org/ec-code/1.2.1.27
is: SBO:0000176
name: methylmalonate-semialdehyde dehydrogenase
product: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000269

metaR r1603
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#

metaR r2354
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaR r1604
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PCm
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
name: pyruvate carboxylase
is described by: ECO:0000269
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.1
reversible: false
modifier: MODEL1310110028#

metaM HC02207 c
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
constant: false
name: prostaglandin-c2
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR LTC4CP
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reactant: MODEL1310110028#
is described by: ECO:0000000
fast: false
name: Leukotriene C4 carboxypeptidase
kinetic law: MODEL1310110028#
is: SBO:0000176
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ba1ab8ae_2751_4312_b265_38a80ce2ab74
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10682
name: EBP
is: SBO:0000252
constant: false
boundary condition: true
is: Q15125
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_409f1179_77c8_4a87_95b3_9e114c9f8594
has part: Q53XN1
has part: P14854
has part: P15954
has part: P09669
has part: P13073
is encoded by: hsa:125965
is encoded by: hsa:1347
has part: Q96KJ9
is encoded by: hsa:1351
is encoded by: hsa:1329
is encoded by: hsa:84701
is encoded by: hsa:1345
is encoded by: hsa:1339
is encoded by: hsa:4514
has part: Q6YFQ2
has part: Q7Z4L0
has part: Q6FGA0
has part: P20674
is encoded by: hsa:1337
is encoded by: hsa:4512
is encoded by: hsa:9377
has part: Q02221
has part: P24311
is encoded by: hsa:9167
is: SBO:0000297
is encoded by: hsa:1346
is encoded by: hsa:341947
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1327
boundary condition: true
initial concentration: NaN
has part: H0UI06
has only substance units: false
is encoded by: hsa:170712
has part: P00414
constant: false
has part: Q8TF08
has part: P24310
has part: Q53YB7
initial amount: NaN
is encoded by: hsa:1349
is encoded by: hsa:1340
type: Species
is encoded by: hsa:4513
is encoded by: hsa:1350
has part: Q7GXZ8
has part: P12074
has part: Q7GXY8

metaR CLPNDt
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
name: fatty acid transport via diffusion
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000000

metaM tdcoa x
is: CHEBI:57385
type: Species
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01521
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
boundary condition: false
is: C02593

metaM cs a deg3 l
is: HMDB00127
boundary condition: false
is: SBO:0000247
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
initial concentration: 1.0
constant: false
is: CHEBI:15748
has only substance units: false
type: Species

metaR r2355
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
name: Organic anion transporter 5 Utilized transport
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#

metaM hdcea e
is: CHEBI:32372
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03229
name: Hexadecenoate (n-C16:1)

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaM chol n
constant: false
initial amount: NaN
is: HMDB00097
has only substance units: false
type: Species
name: choline
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false

metaR r0639
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110028#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_15f97a17_3058_424b_a67b_5080f633017c
is: Q9NZJ6
boundary condition: true
has only substance units: false
is encoded by: hsa:51805
type: Species
name: COQ3
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR DM ethamp r
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_b333da9d_82c2_4d07_93d7_d84182e3be78
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:80150
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
name: ASRGL1
is: Q7L266

metaR r1565
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM g2m8masn r
notes: FORMULA: C82H137N2O65X CHARGE: 0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: C05874
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

metaR CYTK10n
kinetic law: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
name: cytidylate kinase (CMP,dGTP),nuclear
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaM but c
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:17968
has only substance units: false
name: butyrate
is: HMDB00039
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r1605
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110028#
reversible: true

metaM ha pre1 e
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
name: hyaluronan biosynthesis, precursor 1
boundary condition: false
is: CHEBI:16126
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

metaM T4hcinnm m
initial concentration: 1.0
initial amount: NaN
name: trans-4-coumarate
is: SBO:0000247
is: HMDB02035
has only substance units: false
constant: false
boundary condition: false
type: Species
is: CHEBI:12876
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811

http://identifiers.org/biomodels.db/MODEL1310110028#_bee267d7_40ba_48eb_90a6_0f86592bd0d2
constant: false
initial concentration: NaN
is: SBO:0000252
name: NDUFV1
initial amount: NaN
type: Species
boundary condition: true
is: E5KNH5
has only substance units: false
is encoded by: hsa:4723

metaR COQ6m
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: Ubiquinone biosynthesis monooxgenase COQ6
reversible: false
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110028#

metaR r1562
product: MODEL1310110028#
reactant: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185

metaR r2352
kinetic law: MODEL1310110028#
reversible: true
product: MODEL1310110028#
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110028#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM ala B m
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
name: beta-alanine
has only substance units: false
boundary condition: false
is: HMDB00056
is: CHEBI:16958

metaR NACHEX9ly
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
fast: false
reversible: false
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110028#
is described by: ECO:0000000

metaR ADPCOACROT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR GDPtg
is: SBO:0000185
name: GDP intracellular transport
product: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
type: Reaction
kinetic law: MODEL1310110028#
fast: false
reversible: true

metaM HC02207 e
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
type: Species
name: prostaglandin-c2
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:27555

metaR r1606
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185

metaR S6TASE17ly
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: true
product: MODEL1310110028#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_e076daf4_fbbf_4e72_88e2_2af7e74a4de9
initial concentration: NaN
name: COX7B2
is: Q8TF08
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:170712
has only substance units: false

metaM 3octdectecoa x
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
boundary condition: false
constant: false
name: 3,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species
has only substance units: false
initial concentration: 1.0

metaR PGDI
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
kinetic law: MODEL1310110028#
is described by: ECO:0000269
modifier: MODEL1310110028#
name: Prostaglandin-H2 D-isomerase [Precursor]
reversible: true
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/5.3.99.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.18
type: Reaction

metaM m8mpdol U r
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
is: CHEBI:59093
initial amount: NaN
is: SBO:0000247

metaR FAOXC11C9m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaM c81crn e
initial concentration: 1.0
name: octenoyl carnitine
notes: FORMULA: C15H27NO4 CHARGE: 0
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB13324
initial amount: NaN
is: SBO:0000247

metaR r2353
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110028#
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_3e3b4c3d_ec67_447a_874f_34f18860fc98
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:728441
name: GGT2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM hdcea c
is: HMDB03229
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:32372
name: Hexadecenoate (n-C16:1)
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

http://identifiers.org/biomodels.db/MODEL1310110028#_06743272_f7b1_4a45_850d_155166e90d25
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: _AA177072_1_x
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA177072
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_f79feada_194c_4153_84e1_647dcef1d323
initial amount: NaN
name: ALDH1B1
is: SBO:0000252
has only substance units: false
is: P30837
constant: false
is encoded by: hsa:219
type: Species
boundary condition: true
initial concentration: NaN

metaR r1563
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110028#

metaM glyclt c
constant: false
initial concentration: 1.0
name: glycolate
has only substance units: false
is: CHEBI:29805
boundary condition: false
type: Species
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: HMDB00115
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_45b90f9d_19fd_48f9_9ae8_c2087fe8beee
boundary condition: true
type: Species
is encoded by: hsa:3423
initial amount: NaN
constant: false
is: SBO:0000252
name: IDS
is: P22304
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_c579b406_a699_40ab_9e2c_9f46d73329c9
boundary condition: true
name: SLC2A13
is: Q96QE2
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:114134
has only substance units: false

metaR HSD3B7P
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is: SBO:0000176
reversible: false
name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
is version of: http://identifiers.org/ec-code/1.1.1.181
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR BDHm
is: SBO:0000176
modifier: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.30
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
product: MODEL1310110028#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT

metaR r0789
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
is: SBO:0000176
fast: false
modifier: MODEL1310110028#

metaR TYRt
fast: false
product: MODEL1310110028#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
modifier: MODEL1310110028#
name: L-tyrosine transport
is: SBO:0000185

metaM eicostetcoa c
is: SBO:0000247
type: Species
boundary condition: false
constant: false
has only substance units: false
name: eicosatetranoyl coenzyme A
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0
is: C16164
initial amount: NaN

metaM lnlnca e
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388
is: CHEBI:32387
name: alpha-linolenate
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_a53d13c2_1dc7_4544_a031_fbeb90d553b0
has only substance units: false
is encoded by: hsa:8396
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PIP4K2B
type: Species
is: P78356
boundary condition: true

metaR DMNONCRNCPT2
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
name: DMNONCRNCPT2
reversible: true
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
fast: false
product: MODEL1310110028#

metaR r0226
kinetic law: MODEL1310110028#
reversible: false
type: Reaction
product: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
fast: false
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3

metaM leuktrB4 e
is: HMDB01085
boundary condition: false
is: CHEBI:57461
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
type: Species
initial amount: NaN
name: leukotriene B4(1-)
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r1560
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000

metaR r2128
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
is: SBO:0000185

metaM CE5121 m
name: trans-3-decenoyl-CoA
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false
initial amount: NaN
is: CHEBI:57449

metaR r0082
product: MODEL1310110028#
type: Reaction
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.2
modifier: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaR r0788
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
reversible: true
type: Reaction
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR PETOHMr hs
name: phosphatidylethanolamine N-methyltransferase
kinetic law: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.1.17
is: SBO:0000176
fast: false
reactant: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000254

metaM arg L m
initial concentration: 1.0
name: L-argininium(1+)
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00517
boundary condition: false
is: CHEBI:32682
type: Species
initial amount: NaN
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

metaR NAGLCAly
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
name: N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is: SBO:0000176
type: Reaction

metaR r1600
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false

metaM ksi deg5 l
initial amount: NaN
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
boundary condition: false
is: CHEBI:12936
has only substance units: false
is: SBO:0000247
is: HMDB00143
type: Species
name: keratan sulfate I, degradation product 5
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_427c7f20_6ef0_4e90_b1b3_eeb889eddcc2
name: AKR1D1
is: P51857
constant: false
is encoded by: hsa:6718
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaR r1561
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR r2129
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110028#

metaR ASCBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
product: MODEL1310110028#
name: L-ascorbate transport via facilitated diffusion
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR r0081
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
product: MODEL1310110028#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2

metaM c81crn c
name: octenoyl carnitine
boundary condition: false
notes: FORMULA: C15H27NO4 CHARGE: 0
has only substance units: false
constant: false
is: HMDB13324
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_3f753eeb_3116_456b_a443_7a6839f5d525
has only substance units: false
is: SBO:0000252
is: Q6IRT1
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:128
boundary condition: true
initial amount: NaN
name: ADH5

metaR EX decdicrn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_e7bb3980_9c47_4a93_b7ef_0ef8ca9066fd
constant: false
boundary condition: true
is encoded by: hsa:7915
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: Q546H9
name: ALDH5A1

http://identifiers.org/biomodels.db/MODEL1310110028#_0b33e61e_918a_4983_97a5_7ba27282f826
has only substance units: false
boundary condition: true
name: ETFA:ETFB
has part: P13804
initial concentration: NaN
constant: false
is encoded by: hsa:2108
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:2109
type: Species

metaR DHPM1
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.5.2.2
type: Reaction
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
reversible: false
name: dihydropyrimidinase (5,6-dihydrouracil)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_6363c93c_904e_4568_85e6_9a6208225524
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: RDH12
constant: false
is: Q96NR8
is encoded by: hsa:145226
initial concentration: NaN
has only substance units: false

metaR RE0830C
type: Reaction
name: RE0830
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000176
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_36ddca6b_d4e6_4100_9389_e77f5dc1e866
initial concentration: NaN
name: ENTPD1
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:953
boundary condition: true
type: Species
is: Q86VV3
has only substance units: false

metaM btcoa m
name: Butanoyl-CoA
is: SBO:0000247
is: HMDB01088
initial concentration: 1.0
is: CHEBI:57371
type: Species
has only substance units: false
is: C00136
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial amount: NaN
boundary condition: false

metaR r2126
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110028#

metaR r0084
modifier: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110028#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
reversible: true
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR PAIL4P HStn
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
type: Reaction
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110028#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110028#

metaM ksii core4 deg4 l
boundary condition: false
notes: FORMULA: C66H108N6O48SX CHARGE: -1
is: CHEBI:57455
initial concentration: 1.0
is: HMDB01354
is: SBO:0000247
type: Species
constant: false
name: keratan sulfate II (core 4-linked), degradation product 4
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_8176e77e_0e76_4dac_81df_110b801d259b
has only substance units: false
is encoded by: hsa:1716
constant: false
initial concentration: NaN
is: E5KSL5
name: DGUOK
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

metaM sql r
has only substance units: false
initial concentration: 1.0
name: squalene
is: CHEBI:15440
initial amount: NaN
type: Species
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00256

http://identifiers.org/biomodels.db/MODEL1310110028#_ca25cfac_6754_4957_b00c_b1166d8ea890
is: SBO:0000252
is: Q9Y666
constant: false
type: Species
is encoded by: hsa:10723
initial concentration: NaN
initial amount: NaN
name: SLC12A7
has only substance units: false
boundary condition: true

metaR NADPHtxu
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000185
reversible: false
name: NADPH transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#

metaM 2hexdtricoa m
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
name: 2,7,10-hexadecatrienoylcoa
has only substance units: false
is: HMDB02288
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaM 2mp2coa m
is: SBO:0000247
has only substance units: false
is: HMDB01011
is: CHEBI:27754
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: 2-Methylprop-2-enoyl-CoA
constant: false

metaR r1602
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#
reversible: true
fast: false
product: MODEL1310110028#

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_021e8801_fcec_4ff0_a71e_84190c0a3192
constant: false
is: SBO:0000252
is encoded by: hsa:284273
type: Species
has only substance units: false
is: Q4G1C4
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ZADH2

metaR r2127
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
modifier: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110028#

metaR r0083
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaR r0196
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is described by: ECO:0000000
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
type: Reaction
is: SBO:0000176

metaR r0086
type: Reaction
is: SBO:0000176
reactant: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/3.5.1.3
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false

metaR r1451
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
name: EC:1.3.3.6
reversible: false
type: Reaction
is: SBO:0000176

metaR FAOXC121x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaM dlnlcgcoa r
type: Species
is: CHEBI:27979
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
is: C03595
has only substance units: false
constant: false
initial concentration: 1.0

metaR r0191
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.24
is: SBO:0000176
reversible: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11

metaM ctdecdcoa m
name: cis2trans4decadienoylcoa
is: C08277
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00792
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_f4239f4f_aa5b_4514_951a_f9eb285af14f
constant: false
is: SBO:0000252
initial concentration: NaN
name: DHCR24
is encoded by: hsa:1718
is: Q15392
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

metaR r1144
is described by: ECO:0000000
modifier: MODEL1310110028#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_212319ff_c206_4f63_813f_b3c7aab1d0dc
has only substance units: false
is encoded by: hsa:8613
constant: false
type: Species
initial amount: NaN
is: O14495
initial concentration: NaN
name: PPAP2B
is: SBO:0000252
boundary condition: true

metaR S6TASE18ly
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
fast: false

metaR FTHFL
type: Reaction
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110028#
is described by: ECO:0000134
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
name: Formate-tetrahydrofolate ligase
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR NAHCO3 HCLt
reversible: true
type: Reaction
fast: false
product: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
reactant: MODEL1310110028#
name: bicarbonate transport (HCl/NaHCO3 exchange)

metaM na1 r
is: SBO:0000247
constant: false
has only substance units: false
name: sodium(1+)
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:29101
is: HMDB00588
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330

http://identifiers.org/biomodels.db/MODEL1310110028#_ac6c142a_0252_4048_88e1_a1108df4c1af
is: SBO:0000252
is: O95498
constant: false
type: Species
name: VNN2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:8875
has only substance units: false

metaR r0085
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.42
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaR FUMAC
name: fumarylacetoacetase
reactant: MODEL1310110028#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.7.1.2

metaM aicar c
is: C04677
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: HMDB01517
has only substance units: false
is: CHEBI:58475
boundary condition: false
is: SBO:0000247
type: Species
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_d5a3ed98_d19a_425a_ad22_cfb30bb3cca6
is: O75251
type: Species
is encoded by: hsa:374291
constant: false
name: NDUFS7
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR ME1m
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
name: malic enzyme (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.38
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176

metaM damp c
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
boundary condition: false
type: Species
constant: false
initial amount: NaN
name: dAMP(2-)
is: SBO:0000247
is: CHEBI:58245
has only substance units: false
is: HMDB00905
initial concentration: 1.0

metaR ACACT7p
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
modifier: MODEL1310110028#
reversible: false
type: Reaction
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000269
product: MODEL1310110028#
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal

metaR RE0830N
is: SBO:0000176
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
name: RE0830
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110028#

metaM uacgam c
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
constant: false
is: CHEBI:57705
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
type: Species

metaR r0193
is: SBO:0000176
fast: false
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
type: Reaction

metaM hexdtrcoa m
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: HMDB02288
name: 7,10,13-hexadecatrienoylcoa
boundary condition: false

metaM ksi deg1 l
boundary condition: false
type: Species
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 1
initial concentration: 1.0
is: HMDB00174
constant: false
is: CHEBI:18287

metaM Lpipecol x
type: Species
initial amount: NaN
boundary condition: false
name: L-pipecolic acid
has only substance units: false
is: SBO:0000247
is: HMDB00716
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
constant: false
is: CHEBI:30913
initial concentration: 1.0

metaR FAS140COA
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110028#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: fatty-acyl-CoA synthase (n-C14:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110028#_d9be7cd9_5f10_49df_8f36_5114462be06a
constant: false
boundary condition: true
type: Species
is: P30838
is encoded by: hsa:218
is: SBO:0000252
name: ALDH3A1
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_46639740_bf72_481f_95fd_950b98a753ba
has only substance units: false
is encoded by: hsa:80308
constant: false
initial concentration: NaN
boundary condition: true
name: FLAD1
initial amount: NaN
type: Species
is: SBO:0000252

metaM leuktrB4 c
is: CHEBI:57461
has only substance units: false
initial amount: NaN
is: HMDB01085
is: SBO:0000247
type: Species
name: leukotriene B4(1-)
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165

metaM occoa x
is: HMDB01070
constant: false
type: Species
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
is: CHEBI:57386
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C01944

metaR DLNLCGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110028#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_9e9bdb2c_6074_4b4c_927f_ff65f9a4b8c8
constant: false
is: P17050
is encoded by: hsa:4668
name: NAGA
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaM m2emgacpail hs r
initial concentration: 1.0
type: Species
is: C00080
is: SBO:0000247
has only substance units: false
boundary condition: false
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
initial amount: NaN
constant: false
is: CHEBI:24636
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
is: http://identifiers.org/pubchem.compound/3380

metaM 3mgcoa m
is: CHEBI:57346
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial concentration: 1.0
constant: false
is: HMDB01057
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: trans-3-methylglutaconyl-CoA(5-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_abfa7669_19a0_41f3_b5cd_08768ad1596b
name: PKM2
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5315
boundary condition: true
has only substance units: false
is: P14618

metaM 2hexdtricoa x
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: 2,7,10-hexadecatrienoylcoa
is: SBO:0000247

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR r0634
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: true

metaM ha pre1 l
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
is: SBO:0000247
boundary condition: false
is: CHEBI:16126
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_149645ec_f9d4_406b_927f_799a1110b6ee
is encoded by: hsa:7378
boundary condition: true
type: Species
name: UPP1
is: Q16831
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR 4HGLSDm
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000212

metaM ksi pre12 g
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 12
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00175
type: Species
constant: false
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: C00130
boundary condition: false

metaR r1143
is: SBO:0000185
fast: false
reactant: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
type: Reaction
reversible: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_c6ff15db_d5ac_439d_941c_f01c258ed20a
name: GALNS
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P34059
type: Species
constant: false
is encoded by: hsa:2588

metaM 20ahchsterol m
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
is: CHEBI:1296
is: SBO:0000247
constant: false
has only substance units: false
name: 20-hydroxycholesterol
boundary condition: false
type: Species
is: HMDB06283
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_95c70c2d_4199_4cce_875a_2fa78e1c0947
initial concentration: NaN
is encoded by: hsa:5198
boundary condition: true
name: PFAS
constant: false
is: Q6P4B4
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_d22478ec_bf0a_4495_981e_996e5177f66d
constant: false
boundary condition: true
is: O75610
name: LEFTY1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:10637

http://identifiers.org/biomodels.db/MODEL1310110028#_cd702501_10b4_4209_b39e_7fb8589fdc63
is: Q02338
has only substance units: false
is encoded by: hsa:622
name: BDH1
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaR r0633
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.3
is: SBO:0000176
reversible: true
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_97b2f843_fcf4_4ce3_9615_4c6061af7474
is encoded by: hsa:U37519
constant: false
initial concentration: NaN
boundary condition: true
name: _U37519_1_c
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaR r1568
kinetic law: MODEL1310110028#
fast: false
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM tdcoa m
is: CHEBI:57385
constant: false
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
initial concentration: 1.0
is: C02593
boundary condition: false
is: HMDB01521
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_8710f6f1_b4a7_4b85_a2aa_5012601957cb
initial concentration: NaN
constant: false
has part: A8K7W0
is: SBO:0000297
has part: O95497
type: Species
is encoded by: hsa:55350
is encoded by: hsa:8875
initial amount: NaN
is encoded by: hsa:8876
has only substance units: false
name: VNN3:VNN2:VNN1
boundary condition: true

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR r2519
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_489d6beb_00fe_4a02_a7f2_99291434c89a
name: PIK3R5:PIK3CG
constant: false
is encoded by: hsa:23533
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000297
has part: Q8WYR1
initial amount: NaN
has only substance units: false

metaR r1607
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110028#
type: Reaction

metaM arg L e
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:32682
name: L-argininium(1+)
initial concentration: 1.0
is: HMDB00517
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065

metaR r0339
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is: SBO:0000176
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.2.22
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
type: Reaction
product: MODEL1310110028#
reversible: false
fast: false

metaR CO2ter
reversible: true
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
name: CO2 endoplasmic reticular transport via diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110028#

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR CYTK7n
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110028#
is described by: ECO:0000269
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
reversible: true
name: cytidylate kinase (CMP,UTP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaM dag hs c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
initial amount: NaN
is: CHEBI:18035
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_1c9a69d7_99d8_4224_a701_44c47e9c50a3
name: PIK3R1
boundary condition: true
initial amount: NaN
constant: false
is: B3KT19
is encoded by: hsa:5295
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR r1569
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
product: MODEL1310110028#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_4083ea72_1a43_4806_b628_83d800d2b150
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:79087
type: Species
is: Q9BV10
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ALG12

http://identifiers.org/biomodels.db/MODEL1310110028#_70e47e35_146f_403e_a094_501f7c66e0e5
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8528
name: DDO

metaM uacgam g
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00290
has only substance units: false
is: CHEBI:57705
initial concentration: 1.0
type: Species

metaM btcoa x
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
name: Butanoyl-CoA
is: C00136
type: Species
is: HMDB01088
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0

metaR DPCOAtl
reversible: true
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
name: dephospho-CoA transport from lysosome via diffusion
is described by: ECO:0000000
product: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
fast: false

metaM 12ppd R c
boundary condition: false
is: CHEBI:28972
is: HMDB01881
constant: false
name: (R)-propane-1,2-diol
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_0a3f4a94_9076_4a36_819c_e3ba50a12b82
name: ADCY6
is: O43306
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:112
type: Species

metaR r2518
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

metaR ACITL
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: ATP-Citrate lyase
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
fast: false
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.3.8
modifier: MODEL1310110028#

metaR PAIL HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
name: phosphatidylinositol nuclear transport (diffusion)
is: SBO:0000185

metaR r1608
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
reversible: true
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1453
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
reversible: true
is described by: ECO:0000000
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#

metaR PCt
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
is: SBO:0000185
reversible: true
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.6.3.44
is described by: ECO:0000269
fast: false
name: phosphatidylcholine transporter
type: Reaction

metaR r1566
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM eicostetcoa m
is: SBO:0000247
name: eicosatetranoyl coenzyme A
has only substance units: false
boundary condition: false
is: C16164
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_d7db4e8a_cc46_472d_965d_5da31d82e7fc
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7358
name: UGDH
type: Species
boundary condition: true
initial amount: NaN
is: O60701
is: SBO:0000252
constant: false

metaM HC01361 e
boundary condition: false
is: CHEBI:17001
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: Dihydroneopterin
constant: false
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
initial amount: NaN

metaR r0638
is version of: http://identifiers.org/ec-code/2.8.1.2
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000176
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_c633c7d5_2ad4_4079_93f8_8405e1bf3509
type: Species
initial concentration: NaN
is: Q8TD30
initial amount: NaN
constant: false
is encoded by: hsa:84706
name: GPT2
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR NODe
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
name: NODe
kinetic law: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185

metaM arg L c
is: SBO:0000247
type: Species
initial amount: NaN
name: L-argininium(1+)
has only substance units: false
is: HMDB00517
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
boundary condition: false
is: CHEBI:32682

metaM hxan e
is: CHEBI:17368
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: hypoxanthine
initial concentration: 1.0
constant: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
type: Species
is: HMDB00157

metaR FACOAL2042
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
reactant: MODEL1310110028#
reversible: true
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
name: fatty-acid--CoA ligase
modifier: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction

metaR FRUt1r
reversible: true
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
name: D-fructose transport in via uniport
notes: GENE_ASSOCIATION: (29988.1) or (6514.1) or (155184.1) or (6518.1) or (66035.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10821868,PMID:10860996,PMID:11583593,PMID:11780753,PMID:11882499,PMID:12135767,PMID:12750891,PMID:15033637,PMID:1634504,PMID:1695905,PMID:1701966,PMID:2182619,PMID:3399500,PMID:8419132,PMID:9770484 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110028#

metaM ocdcea r
name: octadecenoate (n-C18:1)
is: C00712
is: CHEBI:0
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
boundary condition: false
is: HMDB00207
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_9d870b21_96a1_4f06_a43f_9d3a798f9aa0
has only substance units: false
initial concentration: NaN
type: Species
is: B7Z3W8
name: SLC6A9
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6536
constant: false
initial amount: NaN

metaR r1609
fast: false
product: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_2343ccfa_57d3_441b_a5cc_e4b65e65b8f6
is: O43678
is: SBO:0000252
is encoded by: hsa:4695
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: NDUFA2
constant: false
has only substance units: false

metaM ksi deg37 l
initial amount: NaN
name: keratan sulfate I, degradation product 37
is: SBO:0000247
notes: FORMULA: C62H104N4O46 CHARGE: 0
boundary condition: false
type: Species
has only substance units: false
is: HMDB01354
constant: false
initial concentration: 1.0
is: CHEBI:57455

metaM 3oddcoa m
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
boundary condition: false
is: HMDB03937
type: Species
initial amount: NaN
is: CHEBI:27868
has only substance units: false
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
constant: false

metaM dag hs e
has only substance units: false
is: CHEBI:18035
initial concentration: 1.0
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
name: diglyceride

metaR r1567
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM xol7a r
name: 20-hydroxycholesterol
is: HMDB01496
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:1296
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_07384af5_30be_4c26_b50e_659e0787315e
type: Species
is: SBO:0000252
name: PIGM
is encoded by: hsa:93183
initial concentration: NaN
is: Q9H3S5
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaM pristcoa c
name: pristanoyl coa
is: CHEBI:51341
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaR AG13T4g
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110028#
reversible: false

metaR FOAXC122C101x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

metaR EX urea LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urea exchange
type: Reaction

metaR C100CPT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_a0c83b9f_1457_4350_8a47_3e9f5ab0cba6
name: OXSM
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:54995
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q9NWU1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_bd6a1150_a7a5_4936_9607_0c3573de464f
is: SBO:0000252
name: COX3
constant: false
is encoded by: hsa:4514
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P00414
boundary condition: true

metaR PI5P3K
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.153
type: Reaction
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
kinetic law: MODEL1310110028#
reversible: false
fast: false
name: phosphatidylinositol-5-phosphate 3-kinase
modifier: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110028#_ed54319d_422e_4d13_897a_17905fd14e91
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8574
name: AKR7A2
initial concentration: NaN
constant: false
is: O43488
boundary condition: true

metaR G14T12g
product: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
reversible: false

metaM dag hs r
initial concentration: 1.0
is: SBO:0000247
constant: false
name: diglyceride
type: Species
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
has only substance units: false
initial amount: NaN
boundary condition: false

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR 13DAMPPOX
reversible: false
fast: false
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
kinetic law: MODEL1310110028#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.4.3.21
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_3eaa17db_69b9_4800_99be_c46c71abb9d6
is encoded by: hsa:84532
initial concentration: NaN
is: Q9NUB1
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: ACSS1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_4d511ca2_c026_4484_afb1_185de0748466
initial amount: NaN
name: _AI935189_1_m
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI935189
constant: false

metaR BILDGLCURt
kinetic law: MODEL1310110028#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000269
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
fast: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true

metaM hs deg21 l
notes: FORMULA: C37H55NO38S2 CHARGE: -4
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16126
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_10853e42_cf34_4e70_9609_854518cdf6f2
initial concentration: NaN
is encoded by: hsa:83549
is: SBO:0000252
constant: false
is: Q5JT09
has only substance units: false
boundary condition: true
name: UCK1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_dffd6654_f572_4a04_9d49_f7ad35383073
is: Q9P212
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:51196
name: PLCE1
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r2200
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is described by: ECO:0000000
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaM lald D c
constant: false
initial amount: NaN
is: CHEBI:17167
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: HMDB06458
name: (R)-lactaldehyde
boundary condition: false
type: Species
initial concentration: 1.0

metaM pail45p hs m
has only substance units: false
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_f3141495_388c_45fc_ac26_e224c94ccdb2
is: B3KQV3
name: PIP4K2C
is encoded by: hsa:79837
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR SEBCOACROT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR r0791
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110028#
reversible: true
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR GALASE1ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000

metaM ha deg1 l
constant: false
name: hyaluronan degradation product 1
is: CHEBI:16336
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C22H33N2O16 CHARGE: -1
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_161b7f4d_b20f_478f_9f1f_c1a091ef25ee
boundary condition: true
type: Species
is encoded by: hsa:23464
constant: false
is: SBO:0000252
name: GCAT
is: E2QC23
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR HDD2COAtx
reactant: MODEL1310110028#
name: hdd2coa intracellular transport
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
fast: false
is: SBO:0000185

metaR 3AIBTm
kinetic law: MODEL1310110028#
fast: false
reversible: true
product: MODEL1310110028#
type: Reaction
name: L-3-aminoisobutyrate transaminase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000304
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.6.1.19
reactant: MODEL1310110028#

metaM gly e
is: CHEBI:3339
initial amount: NaN
is: C00037
has only substance units: false
type: Species
initial concentration: 1.0
name: Glycine
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
constant: false
is: HMDB00123
is: SBO:0000247

metaR LINKDEG1ly
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110028#
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal

metaM 5aop m
is: C00430
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:17549
name: 5-Amino-4-oxopentanoate
is: HMDB01149

http://identifiers.org/biomodels.db/MODEL1310110028#_b659bb50_cc28_4362_99c0_e9a2ff5863d0
initial concentration: NaN
initial amount: NaN
is: Q86YB7
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:55268
has only substance units: false
type: Species
name: ECHDC2

metaR HS1ly
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.10.1.1
type: Reaction
kinetic law: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110028#
name: heparan-N-sulfatase, lysosomal
is described by: ECO:0000000

metaM odecoa r
type: Species
is: HMDB01322
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: CHEBI:57387
is: SBO:0000247
initial amount: NaN
name: oleoyl-CoA(4-)
initial concentration: 1.0

metaM thbpt4acam c
boundary condition: false
initial concentration: 1.0
is: HMDB02281
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:15374
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_83b60003_3c19_40c9_bdeb_0138709ece2a
type: Species
is: SBO:0000252
is: Q9UBF8
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5298
constant: false
boundary condition: true
name: PI4KB

metaR SO4tl
is described by: ECO:0000269
reactant: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
product: MODEL1310110028#
reversible: true
name: Sulfate transport (lysosome)
type: Reaction
kinetic law: MODEL1310110028#
fast: false

metaR r2141
type: Reaction
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110028#

metaM c226coa c
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
constant: false
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: cervonyl coenzyme A

metaM leuktrE4 c
initial amount: NaN
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB02200
name: leukotriene E4(1-)
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:57462

metaR C140CPT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_1d136b34_d094_4610_ba5c_ced2bd0df5e0
type: Species
initial concentration: NaN
is: SBO:0000252
name: ATP5G2
is encoded by: hsa:517
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false

metaR r0908
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110028#
type: Reaction

metaR r2202
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
modifier: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#

metaR RPI
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
name: ribose-5-phosphate isomerase
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/5.3.1.6
product: MODEL1310110028#
is: SBO:0000176

metaR ACONTm
is described by: ECO:0000134
reactant: MODEL1310110028#
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
kinetic law: MODEL1310110028#
name: Aconitate hydratase
reversible: true
type: Reaction

metaR r2140
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110028#
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110028#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_ca270eb9_92cd_4372_90b2_a6dd092c08e4
is: SBO:0000252
is: Q9HC58
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57419
constant: false
name: SLC24A3
has only substance units: false
type: Species

metaM gly c
is: HMDB00123
is: SBO:0000247
has only substance units: false
is: CHEBI:3339
initial amount: NaN
initial concentration: 1.0
is: C00037
type: Species
name: Glycine
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0
constant: false

metaM CE0693 m
initial amount: NaN
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
type: Species
is: SBO:0000247
is: CHEBI:28387
boundary condition: false
is: HMDB11123
name: 3-oxolaur-6-cis-enoyl-CoA
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_4e37521b_f3fa_4161_ade9_7bd2e4e78d4c
is: P13995
initial amount: NaN
type: Species
is encoded by: hsa:10797
initial concentration: NaN
name: MTHFD2
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaR r0909
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reversible: true
name: Transport reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaM octe5coa m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
constant: false
has only substance units: false
initial concentration: 1.0
name: 5-octenoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
type: Species

metaM tdcrn e
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0
type: Species
initial concentration: 1.0
is: HMDB05066
initial amount: NaN
boundary condition: false
name: myristoyl carnitine

metaM pail45p hs n
constant: false
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28910
is: SBO:0000247

metaM dmnoncrn c
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB06202
constant: false
is: SBO:0000247
has only substance units: false
name: 4,8-dimethylnonanoyl carnitine
notes: FORMULA: C18H37NO4 CHARGE: 0
initial amount: NaN

metaR r2201
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction

metaM fuc L l
type: Species
initial amount: NaN
constant: false
name: L-fucose
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00174
is: CHEBI:18287
has only substance units: false

metaM leuktrE4 e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
constant: false
is: HMDB02200
name: leukotriene E4(1-)
is: SBO:0000247
is: CHEBI:57462
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_b573f96a_aa5b_4664_870c_85aad693cb16
is encoded by: hsa:521
boundary condition: true
initial amount: NaN
name: ATP5I
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: P56385
is: SBO:0000252

metaM cys L e
is: CHEBI:17561
initial concentration: 1.0
is: HMDB00574
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
name: L-cysteine
has only substance units: false
type: Species

metaR r0641
modifier: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.4
fast: false
product: MODEL1310110028#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_fdd5a3f7_57e9_4360_b640_9c8e9b10b35c
initial concentration: NaN
is: P42336
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: PIK3CA
is encoded by: hsa:5290

metaM dgsn m
is: HMDB00085
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Deoxyguanosine
is: C00330
constant: false
type: Species
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial amount: NaN
initial concentration: 1.0

metaR RPE
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.1
reversible: true
fast: false
name: ribulose 5-phosphate 3-epimerase
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000

metaR NACHEX13ly
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110028#
type: Reaction
fast: false
product: MODEL1310110028#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110028#

metaR PSt3
name: phosphatidylserine transport
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reversible: true

metaR RE3006M
name: RE3006
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
fast: false

metaR ICDHy
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
type: Reaction
name: isocitrate dehydrogenase (NADP)
reversible: false
reactant: MODEL1310110028#
modifier: MODEL1310110028#

metaM hexdectecoa m
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB02288
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 2,4,7,10-hexadecatetraenoylcoa
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_41775602_3052_45db_8677_7f3a8d1beec5
initial concentration: NaN
initial amount: NaN
type: Species
is: O43252
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9061
has only substance units: false
name: PAPSS1
constant: false

metaR FAOXC8C6x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ecb177da_4ba0_4d62_8ac0_f0a197b52560
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:2880
name: GPX5
is: O75715
initial concentration: NaN
is: SBO:0000252

metaR r0642
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
product: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_385a0976_d354_4864_8674_0af69dd7b773
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6530
is: SBO:0000252
boundary condition: true
name: SLC6A2
constant: false
is: Q96KH8

metaM c12dccoa x
has only substance units: false
name: dodecanedioylcoa
is: HMDB03712
boundary condition: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0

metaR PLA2 2
is: SBO:0000176
reversible: false
reactant: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
name: phospholipase A2
notes: GENE_ASSOCIATION: (8398.1) or (5320.1) or (8398.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.4 Confidence Level: 4 AUTHORS: PMID:9272153,PMID:9417066 NOTES:phosphatidyl choline degradation NJ
is version of: http://identifiers.org/ec-code/3.1.1.4
product: MODEL1310110028#
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_46e8390a_2a93_421d_8e17_1eda43e1426e
is: SBO:0000252
type: Species
is: Q15392
is encoded by: hsa:1718
name: DHCR24
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR EX 25hvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D3 exchange
type: Reaction

metaM tdcrn c
initial concentration: 1.0
type: Species
notes: FORMULA: C21H41NO4 CHARGE: 0
is: HMDB05066
has only substance units: false
name: myristoyl carnitine
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false

metaM dag hs n
initial amount: NaN
initial concentration: 1.0
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
type: Species
is: CHEBI:18035

metaM prostge1 c
constant: false
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:57397
name: prostaglandin E1(1-)
is: SBO:0000247
is: HMDB01442
has only substance units: false

metaM tdcoa c
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
constant: false
is: C02593
is: CHEBI:57385
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01521
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_b8fa488f_2cc5_45d6_b3bf_cf002d5556f9
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q10472
name: GALNT1
is encoded by: hsa:2589
constant: false
type: Species

metaR OCTAt
reversible: true
name: Octanoate transport via diffusion
is: SBO:0000185
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#

metaR UMPK
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110028#
name: UMP kinase
is described by: ECO:0000269
fast: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110028#
is: SBO:0000176
type: Reaction

metaR GLCAASE4ly
is: SBO:0000176
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110028#
reversible: false
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110028#
name: beta-glucuronidase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_3e45d1cb_6bfe_47a1_a6b8_3870be2bb17f
constant: false
initial amount: NaN
is: P19440
is encoded by: hsa:2678
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: GGT1

metaR RE2972M
is version of: http://identifiers.org/ec-code/2.7.1.67
fast: false
product: MODEL1310110028#
is described by: ECO:0000000
name: RE2972
reactant: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
modifier: MODEL1310110028#

metaR FAOXC225C226x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR C4OHc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxybytyryl carnitinec
type: Reaction

metaR S6TASE9ly
fast: false
kinetic law: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110028#
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_47b33c61_6bbe_470e_a9a7_49d4b294ff24
initial concentration: NaN
is: P20674
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:9377
name: COX5A

metaM g3pc c
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C8H20NO6P CHARGE: 0 INCHI: InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/p+1/t8-/m1/s1 EHMN_ABBREVIATION: C00670
is: CHEBI:16870
name: sn-Glycero-3-phosphocholine
is: HMDB00086
constant: false
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_bbfe3746_9293_4311_b49e_37964d163219
name: ATP5J2
is: P56134
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:9551
boundary condition: true
has only substance units: false
constant: false

metaR FAOXC10C10OHm
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaM cys L c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
is: SBO:0000247
is: HMDB00574
type: Species
name: L-cysteine
is: CHEBI:17561

metaM prostge1 e
is: SBO:0000247
name: prostaglandin E1(1-)
is: CHEBI:57397
is: HMDB01442
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
type: Species

metaM ksi deg8 l
is: HMDB00143
type: Species
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I, degradation product 8
is: CHEBI:12936
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a2136758_3731_488a_8761_166b958a6602
is: SBO:0000297
constant: false
has only substance units: false
name: NME1:NME2
type: Species
boundary condition: true
is encoded by: hsa:4830
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_a7d01282_0ef2_4df5_ac68_497e9c0116a2
type: Species
boundary condition: true
is encoded by: hsa:4645
has only substance units: false
is: Q9H6Y6
initial amount: NaN
name: MYO5B
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_498a0008_a937_4114_b0f7_2ccaad4ca281
is: P00439
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5053
name: PAH
boundary condition: true

metaR FACOAL170
reactant: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
type: Reaction
fast: false
name: fatty-acid--CoA ligase

metaR NACHEX21ly
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
reversible: false

metaR C10DCCACT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_a8ddeaf0_c854_4418_b653_cba6cb311ebd
name: PANK4
initial concentration: NaN
is: Q9NVE7
is encoded by: hsa:55229
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR PETHCT
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.14
product: MODEL1310110028#
reversible: false
is: SBO:0000176
name: phosphoethanolamine cytidyltransferase
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaR DLNLCGCPT2
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
is described by: ECO:0000000
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110028#

metaM ribflv c
is: HMDB00244
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: CHEBI:3554
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00255
initial concentration: 1.0
name: Riboflavin

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR S2L2N2M2MASNtly
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
fast: false
reversible: false
is: SBO:0000185
name: s2l2n2m2masn transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110028#
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_82f5ba9c_2fe0_4390_bf07_c85f0c9e6b20
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:26289
initial amount: NaN
name: AK5
type: Species
has only substance units: false

metaM pglyc hs e
type: Species
initial concentration: 1.0
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
has only substance units: false
is: CHEBI:60523
initial amount: NaN
boundary condition: false
constant: false
name: phosphatidylglycerol(1-)
is: SBO:0000247

metaM uacgam r
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57705
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: HMDB00290
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_66fd6a92_a2a4_4e6a_a157_081aea897d7c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: DBT
is encoded by: hsa:1629
is: P11182
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_5a5482e4_4569_435c_b3f5_9710c27c21e1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: TUSC3
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:7991

http://identifiers.org/biomodels.db/MODEL1310110028#_f75dfe80_ebdd_47e7_977b_b4c36877ebb3
name: PTGDS
is: P41222
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:5730
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaM C04849 e
constant: false
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: SBO:0000247
is: CHEBI:57449
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

metaM malthx e
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
type: Species
name: Maltohexaose
initial concentration: 1.0
is: C01936
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false

metaM eipencoa x
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
type: Species
constant: false
boundary condition: false
has only substance units: false
name: 2,5,8,11,14-eicosapentaenoylcoa

metaM hom L c
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: HMDB00719
constant: false
has only substance units: false
name: L-homoserine
initial concentration: 1.0
type: Species
is: CHEBI:15699

metaM thbpt4acam n
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:15374
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
has only substance units: false
initial amount: NaN

metaM fuc L c
has only substance units: false
name: L-fucose
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: HMDB00174
initial concentration: 1.0

metaM dgsn c
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00085
initial amount: NaN
boundary condition: false
is: CHEBI:17172
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
constant: false
name: Deoxyguanosine
is: SBO:0000247

metaM pentcoa m
initial concentration: 1.0
boundary condition: false
is: HMDB13037
is: C00888
type: Species
constant: false
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
name: pentanoylcoa

metaM xol27oh m
type: Species
is: CHEBI:17703
is: HMDB02103
name: 26-hydroxycholesterol
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ada3dff9_00ba_404a_838e_a8832d25bf82
name: _AI620219_1_m
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI620219
initial amount: NaN
type: Species

metaM thr L c
constant: false
is: SBO:0000247
is: HMDB00167
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16857
type: Species

metaR r1581
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000185

metaR r0796
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
modifier: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000000

metaR GLCNACASE3ly
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.2.1.50
is: SBO:0000176
reversible: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110028#
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000000
fast: false

metaM 56dura c
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:15901
name: 5,6-dihydrouracil
is: HMDB00076
type: Species
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial concentration: 1.0
boundary condition: false

metaR THMMPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: Thiamine monophosphate transport, mitochondrial
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction

metaM dudp n
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01000
is: CHEBI:60471
initial amount: NaN
type: Species
name: dUDP(3-)
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_2610535c_351c_460f_882d_788d7c04d07e
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5151
name: PDE8A

metaM hexdectecoa x
is: SBO:0000247
name: 2,4,7,10-hexadecatetraenoylcoa
initial concentration: 1.0
initial amount: NaN
is: HMDB02288
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
type: Species

metaM pglyc hs c
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:21338
is: HMDB02704
name: pglyc_hs[c]
notes: FORMULA: CHARGE: 0
boundary condition: false
initial amount: NaN

metaR r1580
product: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_98cd0b61_aef7_43fd_b846_4bdf5ebb2ad6
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5151
has only substance units: false
initial amount: NaN
constant: false
name: PDE8A
boundary condition: true

metaM HC01406 m
is: CHEBI:28264
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
name: 3-Oxooctanoyl-CoA
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_a7b5fb64_0d31_418a_89b5_7cab9e15a3c0
initial amount: NaN
type: Species
name: NDUFS4
has only substance units: false
is encoded by: hsa:4724
is: O43181
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaM thr L e
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
name: L-threonine
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: HMDB00167

metaM etoh e
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: CHEBI:16236
constant: false
has only substance units: false
is: SBO:0000247
type: Species
name: ethanol
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00108

metaR SBCOAACOTx
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaR r0797
is described by: ECO:0000000
type: Reaction
fast: false
name: glycine N-choloyltransferase EC:2.3.1.65
reactant: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM hom L e
constant: false
is: HMDB00719
boundary condition: false
type: Species
has only substance units: false
name: L-homoserine
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
initial concentration: 1.0
initial amount: NaN

metaR KSII CORE4tly
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core 4) transport, extracellular to lysosome
type: Reaction
is: SBO:0000185
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false

metaR r2357
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_20631f43_275d_4be1_82c2_732ce5396bbb
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:5728
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: F6KD01
name: PTEN

http://identifiers.org/biomodels.db/MODEL1310110028#_3490f4d1_7dad_48f6_a260_26c67bd00a92
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:92483
initial amount: NaN
type: Species
is: SBO:0000252
name: LDHAL6B
initial concentration: NaN
is: Q9BYZ2

metaR r1018
kinetic law: MODEL1310110028#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110028#
product: MODEL1310110028#
name: Transport reaction
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_1466a304_27f4_437f_9391_34dbe6957770
is: Q16836
is: SBO:0000252
has only substance units: false
name: HADH
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3033
initial amount: NaN
type: Species

metaM fuc L e
has only substance units: false
name: L-fucose
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:18287
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

metaR GARFT
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269
name: phosphoribosylglycinamide formyltransferase
type: Reaction
modifier: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_022a6f35_7ca2_49b9_8ecf_a42d50cd55ef
constant: false
is: Q16878
is: SBO:0000252
has only substance units: false
name: CDO1
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:1036
initial amount: NaN

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM chlstol r
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:16290
name: 5alpha-cholesta-7,24-dien-3beta-ol
type: Species
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: HMDB06842
constant: false

metaR LEUTA
modifier: MODEL1310110028#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
reversible: true
name: leucine transaminase
kinetic law: MODEL1310110028#

metaR PIt7
is described by: ECO:0000269
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
reversible: true
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110028#
name: phosphate transport in/out via three Na+ symporter
product: MODEL1310110028#

metaR RDH2a
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
type: Reaction
modifier: MODEL1310110028#
fast: false
name: retinol dehydrogenase (9-cis,NADPH)
reversible: true
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.300
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.105
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_9369f245_2400_4904_99bc_02a1748ed044
has only substance units: false
constant: false
name: GCK
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q53Y25
is encoded by: hsa:2645
boundary condition: true
type: Species

metaR URIK1
is version of: http://identifiers.org/ec-code/2.7.1.48
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
reactant: MODEL1310110028#
type: Reaction
name: uridine kinase (ATP:Uridine)
is: SBO:0000176
product: MODEL1310110028#
is described by: ECO:0000269
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6c8178c5_f737_4657_b1dc_aec6e2d38278
type: Species
is encoded by: hsa:1737
boundary condition: true
constant: false
initial amount: NaN
name: DLAT
is: Q86YI5
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR DNDPt24m
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
reversible: false
name: dTDP transport via dADP antiport
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR r2356
product: MODEL1310110028#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_3ffdb64c_f7ee_4dbd_9b2b_a8f686c3d7ea
is: SBO:0000252
is: O94788
is encoded by: hsa:8854
initial concentration: NaN
name: ALDH1A2
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR r2142
kinetic law: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110028#
reactant: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaR S4TASE4ly
is described by: ECO:0000000
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
modifier: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.12

http://identifiers.org/biomodels.db/MODEL1310110028#_f3bd20eb_2266_4cdf_8a14_981ccd0a74f6
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: PPCDC
is: Q96CD2
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:60490

metaR CSNt
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction
name: cytosine transport via facilated diffusion
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR C4DCCACT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaR PIt8
modifier: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
type: Reaction
is described by: ECO:0000006
kinetic law: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
name: phosphate transport in/out via Na+ symporter
fast: false

metaM dudp m
initial concentration: 1.0
initial amount: NaN
name: dUDP(3-)
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species
is: HMDB01000
is: CHEBI:60471
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR ECOAH9m
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110028#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is described by: ECO:0000304
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM etoh c
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial concentration: 1.0
name: ethanol
type: Species
is: CHEBI:16236
has only substance units: false
is: HMDB00108
is: SBO:0000247

metaR MM7Cbg
reactant: MODEL1310110028#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110028#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_d2508598_796d_4e75_8501_1cba3668c4d9
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:516
name: ATP5G1
is: Q6FIH7
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR r0795
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.225
name: Spontaneous reaction
product: MODEL1310110028#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
modifier: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#

metaR r2359
fast: false
reactant: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true

metaM strdnccrn m
initial amount: NaN
boundary condition: false
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
has only substance units: false
type: Species
constant: false
is: SBO:0000247
name: stearidonyl carnitine
is: HMDB06463
initial concentration: 1.0

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaR RE1527M
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE1527
modifier: MODEL1310110028#
product: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
type: Reaction
fast: false
is: SBO:0000176

metaR FAOXC227C226m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_94ce6425_5a7d_4f96_bd06_6a7ebb89f8b5
initial amount: NaN
name: DGKZ
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: B7Z6M3
type: Species
is encoded by: hsa:8525

metaR PCRNtm
is: SBO:0000185
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
product: MODEL1310110028#
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
name: transport into the mitochondria from cytosol (carnitine)

metaM ribflv e
is: HMDB00244
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C17H20N4O6 CHARGE: 0
type: Species
name: Riboflavin
boundary condition: false
is: C00255
is: CHEBI:3554
constant: false
has only substance units: false

metaM cs e deg4 l
is: HMDB00127
type: Species
notes: FORMULA: C31H46NO38S4 CHARGE: -5
constant: false
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:15748
initial concentration: 1.0

metaR 3AIBtm
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110028#
fast: false
type: Reaction
kinetic law: MODEL1310110028#
reversible: false
name: 3-amino-isobutyrate transport, mitochondrial
product: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

metaR r0792
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
type: Reaction
reversible: true
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
fast: false
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_979c423c_de68_4e75_b32c_0e1b8cb2e974
is: SBO:0000252
constant: false
is: O14561
type: Species
has only substance units: false
initial amount: NaN
name: NDUFAB1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4706

metaR PROt2r
fast: false
name: L-proline reversible transport via proton symport
modifier: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110028#_b277f2a1_07b9_4be7_bcb9_854feea2a741
is: SBO:0000252
is encoded by: hsa:125206
is: A0PJK1
constant: false
name: SLC5A10
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR D LACt2
is: SBO:0000185
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110028#
name: D-lactate transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110028#_5fc27808_7a0d_459b_b2d8_c8455e89585b
is encoded by: hsa:9162
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: DGKI
is: O75912

http://identifiers.org/biomodels.db/MODEL1310110028#_87e988c6_850b_467b_aaa5_4f6b54473cd1
is: B7Z6Q4
is encoded by: hsa:3612
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
name: IMPA1
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_f8aeee86_18f3_4f74_86aa_b493a561ff6e
is: O75355
boundary condition: true
is encoded by: hsa:956
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: ENTPD3
has only substance units: false

metaR FAOXC8C6m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR r1019
product: MODEL1310110028#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r2358
product: MODEL1310110028#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_76122d36_85f8_4070_a9e3_e016c5d410bb
name: GLRX
is: SBO:0000252
is: P35754
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:2745
type: Species

metaM xol27oh r
initial amount: NaN
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
type: Species
name: 26-hydroxycholesterol
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:17703
is: HMDB02103
initial concentration: 1.0

metaR DLNLCGCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_e2c70b30_24cd_478f_91c3_d10db3ef8bb8
type: Species
boundary condition: true
is encoded by: hsa:AA278423
initial concentration: NaN
constant: false
name: _AA278423_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM dec47dicoa m
is: http://identifiers.org/pubchem.compound/16019966
name: 4,7-decadienoylcoa
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
initial amount: NaN

metaR RE2666C
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
fast: false
kinetic law: MODEL1310110028#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110028#
name: RE2666
product: MODEL1310110028#
reversible: false

metaM sph1p c
initial concentration: 1.0
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN
constant: false
is: HMDB01383
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
is: CHEBI:57939
boundary condition: false
has only substance units: false

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM dgdp m
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: CHEBI:58595
boundary condition: false
is: HMDB00960
type: Species
name: dGDP(2-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_9199c979_4cce_4177_8c64_bb9b94c6243c
is: P11310
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:34
is: SBO:0000252
has only substance units: false
type: Species
name: ACADM
constant: false

metaR CYTK6n
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
modifier: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true
is: SBO:0000176
name: cytidylate kinase (CMP,CTP),nuclear
type: Reaction

metaR P5CR
fast: false
type: Reaction
name: pyrroline-5-carboxylate reductase
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: false
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
reactant: MODEL1310110028#

metaR RE1901R
name: RE1901
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799,PMID:11279029 NOTES:
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110028#
fast: false
reversible: true

metaR DESAT22 2p
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110028#
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
reactant: MODEL1310110028#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000176

metaR r1574
type: Reaction
is: SBO:0000185
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaR r2364
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110028#
fast: false
reversible: true
is: SBO:0000185

metaM cs a deg4 l
boundary condition: false
has only substance units: false
is: CHEBI:57455
initial concentration: 1.0
type: Species
notes: FORMULA: C31H49NO29S CHARGE: -2
constant: false
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
is: HMDB01354
is: SBO:0000247

metaR UMPKn
modifier: MODEL1310110028#
name: UMP kinase, nuclear
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
product: MODEL1310110028#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaR PPItm
product: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial
kinetic law: MODEL1310110028#
type: Reaction
fast: false

metaR BALAtmr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
name: Beta-alanine reversible mitochondrial transport (diffusion)
fast: false
type: Reaction
reactant: MODEL1310110028#

metaR NADtx
is described by: ECO:0000134
name: transport of NAD into peroxisome
kinetic law: MODEL1310110028#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110028#

metaR r0497
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
product: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
reactant: MODEL1310110028#

metaR ACCOAtr
modifier: MODEL1310110028#
name: acetyl-coa transport
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ changed name from ACCOArt to ACCOAtr for consistency - NCD
fast: false
reversible: true
type: Reaction

metaR RE3272N
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
product: MODEL1310110028#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110028#
is: SBO:0000176
name: RE3272

http://identifiers.org/biomodels.db/MODEL1310110028#_a658b495_7d86_4b31_8603_165cee125a4c
type: Species
is encoded by: hsa:9123
is: SBO:0000252
is: O15427
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: SLC16A3

metaR r2365
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110028#
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction

metaR r1575
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
type: Reaction
reactant: MODEL1310110028#
is described by: ECO:0000000

metaM 34hpp e
constant: false
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
boundary condition: false
is: HMDB00707
initial amount: NaN
type: Species
has only substance units: false

metaR MMMm
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
product: MODEL1310110028#
is described by: ECO:0000269
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/5.4.99.2
is: SBO:0000176
name: methylmalonyl-CoA mutase
type: Reaction
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_681186de_954a_487b_9db2_765b0f1577fb
type: Species
name: DDOST
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1650
initial amount: NaN
constant: false
is: SBO:0000252
is: P39656

metaM 3tdcrn c
has only substance units: false
notes: FORMULA: C21H41NO5 CHARGE: 0
initial amount: NaN
name: 3-hydroxy-tetradecanoyl carnitine
constant: false
is: HMDB02014
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR RE3301C
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
name: RE3301
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
product: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000

metaM ppi m
constant: false
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00250
is: CHEBI:33019
initial concentration: 1.0
name: Diphosphate
is: SBO:0000247
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

http://identifiers.org/biomodels.db/MODEL1310110028#_e06b8beb_9582_4d8e_b5cd_454203a1958f
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: _AA081045_1_e
is encoded by: hsa:AA081045
boundary condition: true

metaM hexe3coa x
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
name: 3-hexenoylcoa
is: HMDB06522
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
has only substance units: false

metaR r1576
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_78b5c9af_f33a_4540_9abc_5cf9dcfc05bf
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:AV717590
name: _AV717590_1_c

metaR GLCAASE1ly
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110028#
type: Reaction
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110028#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR r2366
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR HPYRDC
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
fast: false
reactant: MODEL1310110028#
type: Reaction
name: hydroxypyruvate decarboxylase
product: MODEL1310110028#

metaR COQ5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
reactant: MODEL1310110028#
type: Reaction
name: Ubiquinone biosynthesis methyltransferase COQ5
is: SBO:0000176
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_b3a21535_7c27_40fb_bc16_55c286ec0b34
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: PRDX1
is encoded by: hsa:5052
boundary condition: true
initial concentration: NaN

metaM dgdp n
is: HMDB00960
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: dGDP(2-)
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
type: Species

metaM ppi n
is: SBO:0000247
initial amount: NaN
is: CHEBI:33019
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
name: diphosphate(3-)
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false

metaR UMPKm
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
type: Reaction
reversible: true
name: UMP kinase (mitochondrial, ATP)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110028#_153f8225_1ac8_4275_89e7_41b9e7da1448
is encoded by: hsa:8803
type: Species
initial concentration: NaN
constant: false
is: E5KS60
name: SUCLA2
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r1020
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
name: Postulated transport reaction

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR SUCCtp
is: SBO:0000185
type: Reaction
name: succinate transporter, peroxisome
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ

http://identifiers.org/biomodels.db/MODEL1310110028#_2a3edf13_eb71_44e7_adf9_d28faa70fdfb
constant: false
name: ELOVL4
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6785
boundary condition: true
type: Species
is: Q9GZR5
is: SBO:0000252

metaR r2367
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000185

metaR AG13T3g
modifier: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_ba17dd6b_22ee_4d61_b1f0_10e03a6e3632
initial amount: NaN
is encoded by: hsa:AU149534
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: _AU149534_1_m
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_30805e9a_5581_4813_bb44_ce0dd7e01212
type: Species
initial amount: NaN
is encoded by: hsa:6240
constant: false
initial concentration: NaN
boundary condition: true
name: RRM1
has only substance units: false
is: P23921
is: SBO:0000252

metaR r0494
product: MODEL1310110028#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR S6TASE22ly
is: SBO:0000176
product: MODEL1310110028#
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
name: galactose-6-sulfate sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23

http://identifiers.org/biomodels.db/MODEL1310110028#_d120eb8c_fc53_4c0e_aa48_f8c85862d702
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5152
boundary condition: true
name: PDE9A
type: Species

metaR P45027A11m
is version of: http://identifiers.org/ec-code/1.14.13.15
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
modifier: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
kinetic law: MODEL1310110028#
fast: false
reversible: false
product: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction

metaR RE3346C
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
name: RE3346
reactant: MODEL1310110028#
modifier: MODEL1310110028#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_7c21c433_3ab1_4e5d_a931_5e2ab9fdd260
initial amount: NaN
has part: Q9BQL0
is: SBO:0000297
has only substance units: false
is encoded by: hsa:594
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: DBT:DLD:BCKDHA:BCKDHB

metaR FAOXC183C163m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_2bfcbef4_29ff_4e4e_8cad_b8834c479c95
initial concentration: NaN
is encoded by: hsa:159
has only substance units: false
is: P30520
type: Species
name: ADSS
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM sbcoa c
type: Species
is: SBO:0000247
is: C02838
has only substance units: false
initial amount: NaN
name: suberylcoa
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial concentration: 1.0
is: HMDB00791
boundary condition: false
constant: false

metaR MM8Cg
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.113
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_4239f276_c98c_4a17_a62d_48f91885e1f7
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: PDE9A
is encoded by: hsa:5152
initial concentration: NaN
has only substance units: false

metaR S6TASE19ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is: SBO:0000176
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaR r1570
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
fast: false
reversible: true

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

metaR r2360
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR PCRNtc
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:7654220 NOTES:NJ
fast: false
reversible: false
name: transport into the cytosol from peroxisome (carnitine)
product: MODEL1310110028#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR HIVCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaR ACCOAtn
type: Reaction
reactant: MODEL1310110028#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110028#
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_c1e8fb66_2545_45de_b000_55d5a33b986f
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM ksi deg3 l
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 3
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:30825
is: SBO:0000247
is: HMDB00573
type: Species
notes: FORMULA: C233H371N16O205S12 CHARGE: -13

metaR ASPTAm
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000269
name: aspartate transaminase
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
reactant: MODEL1310110028#

metaR r2139
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110028#

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR r1571
is described by: ECO:0000000
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#
fast: false

metaM ac c
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30089
is: SBO:0000247
constant: false
name: acetate
type: Species
is: HMDB00042

metaR r2361
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
reversible: true

metaM odecoa c
has only substance units: false
constant: false
is: HMDB01322
initial concentration: 1.0
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:3793

metaM octe5coa x
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
name: 5-octenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
constant: false

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaR TETTET6COAtx
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
reversible: true
fast: false

metaM ak2lgchol hs e
is: http://identifiers.org/pubchem.compound/6975
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: C04317
type: Species
has only substance units: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine

http://identifiers.org/biomodels.db/MODEL1310110028#_d2e39852_5aae_46b2_94fd_968dac3707c0
name: ALOX5
is encoded by: hsa:240
is: P09917
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaM 3pg m
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:58272
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: HMDB00807
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_33ae9c46_84b6_4d48_8cbf_19dd085c10c8
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:26266
is: Q9UKG4
name: SLC13A4
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_2574266e_9a08_470e_9de8_b393f6cf481d
has only substance units: false
type: Species
is: O95045
name: UPP2
constant: false
boundary condition: true
is encoded by: hsa:151531
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_08319a6a_a2e5_4564_836c_d7c2542fdee0
is: SBO:0000252
is: P22392
has only substance units: false
boundary condition: true
name: NME2
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4831

metaM lnlncgcrn m
constant: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
boundary condition: false
name: gamma-linolenyl carnitine
is: HMDB06318
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_508d1387_0444_4ec5_ac83_731131946e8b
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: _AI924226_1_m
is encoded by: hsa:AI924226

metaR P450SCC1m
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
kinetic law: MODEL1310110028#
is: SBO:0000176
reversible: true
is described by: ECO:0000134
type: Reaction
fast: false
reactant: MODEL1310110028#
name: cholesterol monooxygenase
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_52c4b376_b19a_498b_ab62_2fbec9bb45b3
initial concentration: NaN
is encoded by: hsa:4702
initial amount: NaN
constant: false
has only substance units: false
is: B1AM93
name: NDUFA8
type: Species
boundary condition: true
is: SBO:0000252

metaR DHDPBMTm
type: Reaction
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.1.1.114
is described by: ECO:0000269
reactant: MODEL1310110028#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
modifier: MODEL1310110028#
reversible: false
name: dihydroxydecaprenylbenzoate methyltransferase

metaR MI1PP
reactant: MODEL1310110028#
name: myo-inositol 1-phosphatase
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
kinetic law: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110028#
product: MODEL1310110028#

metaM dmnoncrn x
is: SBO:0000247
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
name: 4,8-dimethylnonanoyl carnitine
type: Species
constant: false
has only substance units: false
boundary condition: false

metaR r2362
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
fast: false

metaM 1glyc hs e
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00972
name: 1 acyl phosphoglycerol
is: CHEBI:57454
has only substance units: false

metaM c226coa x
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
constant: false
boundary condition: false
name: cervonyl coenzyme A
is: C16169
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_3d0e8b83_3109_491f_ba7b_f401c08d7571
is encoded by: hsa:5297
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: B4DYG5
boundary condition: true
type: Species
name: PI4KA
initial concentration: NaN

metaM ppi r
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
boundary condition: false
is: C00013
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00250
name: Diphosphate
is: CHEBI:33019

metaM adpac x
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
name: adipic acid
is: HMDB00448
notes: FORMULA: C6H8O4 CHARGE: -2

metaM cs a deg5 l
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
is: CHEBI:15936
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H36O24S CHARGE: -2
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaM 3tdcrn e
initial concentration: 1.0
notes: FORMULA: C21H41NO5 CHARGE: 0
initial amount: NaN
is: HMDB13336
constant: false
name: 3-hydroxy-tetradecanoyl carnitine
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

metaM s7p c
type: Species
name: Sedoheptulose 7-phosphate
is: C05382
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57483
is: HMDB01068
constant: false
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382

http://identifiers.org/biomodels.db/MODEL1310110028#_bad55643_1ba8_49c9_a0c3_855ce4dc80db
type: Species
is: SBO:0000252
is encoded by: hsa:4200
constant: false
name: ME2
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P23368
initial amount: NaN

metaM g2m8mpdol U r
has only substance units: false
initial amount: NaN
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
constant: false
is: CHEBI:59093
type: Species
boundary condition: false
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247

metaR r1573
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false

metaR ADK1m
fast: false
is described by: ECO:0000269
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
name: adenylate kinase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
reversible: true
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.3

metaR r0093
fast: false
is described by: ECO:0000000
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.3
modifier: MODEL1310110028#
reactant: MODEL1310110028#

metaM 34hpp c
name: 3-(4-hydroxyphenyl)pyruvate
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
boundary condition: false
is: CHEBI:36242
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_3c0ddba5_ad8e_4adf_a754_56108ae6d70f
is encoded by: hsa:4696
has part: Q6IBC4
is encoded by: hsa:4704
has part: P03915
has part: Q7GXZ1
has part: O43678
is encoded by: hsa:4724
is encoded by: hsa:4714
has part: O75489
has part: E5KNH5
has part: B1AM93
is encoded by: hsa:4723
constant: false
has part: O75438
has part: Q6FG42
has part: O95168
is encoded by: hsa:374291
has part: P03897
is encoded by: hsa:4708
has part: P19404
has part: P56556
has part: O95299
has part: O00217
has part: Q85KV6
has part: Q6IB80
is encoded by: hsa:4717
is encoded by: hsa:4707
is encoded by: hsa:4538
has part: O95139
initial concentration: NaN
has part: F8VQS7
has part: C9JT23
initial amount: NaN
is encoded by: hsa:4535
has part: O75251
has part: Q6IBB5
is encoded by: hsa:4539
is encoded by: hsa:4694
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: O43181
is encoded by: hsa:4698
has part: O43677
has part: O00483
has part: Q549M5
has part: B7Z792
has part: Q16718
has part: H7C5B8
is encoded by: hsa:4722
is encoded by: hsa:4712
is encoded by: hsa:4716
is encoded by: hsa:4731
is encoded by: hsa:55967
is encoded by: hsa:4540
has part: O43674
is encoded by: hsa:4713
is encoded by: hsa:51079
has part: O95169
has part: P17568
is encoded by: hsa:4706
boundary condition: true
is encoded by: hsa:4537
is encoded by: hsa:4729
is encoded by: hsa:4697
has part: O95167
has part: Q7GXY9
is encoded by: hsa:4720
is encoded by: hsa:4710
is encoded by: hsa:7991
is encoded by: hsa:4702
has part: Q9Y6M9
is encoded by: hsa:126328
has part: Q13454
is encoded by: hsa:4711
is encoded by: hsa:4701
is encoded by: hsa:4715
is encoded by: hsa:4705
has part: P28331
type: Species
has part: Q6IBA0
has part: P03905

metaM ac e
initial amount: NaN
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30089
constant: false
type: Species
name: acetate
is: HMDB00042

metaM pail45p hs c
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:28910
initial amount: NaN
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_e3221a9f_4a4c_4184_ae81_b1ecfe856ff1
is: P31350
is encoded by: hsa:6241
has only substance units: false
boundary condition: true
name: RRM2
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaR r2363
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
type: Reaction

metaR FAOXC122m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaM 3ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: HMDB03952
has only substance units: false
is: C05280
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 3,6-dodecadienoylcoa

metaR r0911
fast: false
name: Facilitated diffusion
product: MODEL1310110028#
reversible: true
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR 5OXPROt
kinetic law: MODEL1310110028#
name: Transport of 5-oxoprolinate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110028#
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
fast: false
reactant: MODEL1310110028#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_c8343bc2_b058_4021_ad16_7cbfebf302fb
is: Q8IW54
constant: false
is encoded by: hsa:5138
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
name: PDE2A
initial concentration: NaN
initial amount: NaN

metaR r0321
reversible: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is version of: http://identifiers.org/ec-code/6.3.5.2
is described by: ECO:0000000
product: MODEL1310110028#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:

metaR FAOXC122x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_2f4b405a_bd19_47fc_b198_bd887a4c8158
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: EHHADH
is encoded by: hsa:1962
is: Q9NY65

metaM lnlncgcrn c
name: gamma-linolenyl carnitine
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB06318
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaM alpam m
type: Species
name: S-aminomethyldihydrolipoamide
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB06239
boundary condition: false
constant: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: SBO:0000247

metaM ak2lgchol hs c
initial concentration: 1.0
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
has only substance units: false
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/6975
is: C04317
boundary condition: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
initial amount: NaN
type: Species

metaM dmnoncrn m
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: 4,8 dimethylnonanoyl carnitine
is: HMDB06202
initial amount: NaN
initial concentration: 1.0

metaM gly m
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: C00037
type: Species
is: CHEBI:15428
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00123
name: Glycine
is: SBO:0000247

metaM 34hpp m
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
constant: false
is: HMDB00707
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
is: SBO:0000247

metaR LNSTLSr
name: lanosterol synthase
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/5.4.99.7
modifier: MODEL1310110028#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
fast: false
reversible: false

metaM hpdca e
is: HMDB02259
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
boundary condition: false
name: margarate
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:32366

metaM dec47dicoa x
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: 4,7-decadienoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a6fffb8d_b426_4952_9160_fa53147584d3
is: SBO:0000252
is: P11310
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:34
name: ACADM
has only substance units: false
initial concentration: NaN
constant: false

metaM cbasp e
initial amount: NaN
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
boundary condition: false
has only substance units: false
notes: FORMULA: C5H6N2O5 CHARGE: -2
constant: false
type: Species
is: C00438
initial concentration: 1.0
is: CHEBI:32814
is: HMDB00828

metaR ASPte
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
reversible: true
name: diffusion of aspartate into blood
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM ppi x
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
is: CHEBI:33019
name: Diphosphate
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00013
is: HMDB00250
initial amount: NaN

metaR O2ter
product: MODEL1310110028#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: O2 transport, endoplasmic reticulum
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR HBZOPT10m
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: Hydroxybenzoate Decaprenyltransferase
is version of: http://identifiers.org/ec-code/2.5.1.39
reversible: false
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT

metaR RE2677E
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
fast: false
product: MODEL1310110028#
is described by: ECO:0000000
name: RE2677
is: SBO:0000176
kinetic law: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#

metaR GALASE13ly
name: beta-galactosidase, lysosomal
is: SBO:0000176
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110028#

metaM acmana r
is: HMDB01129
initial concentration: 1.0
initial amount: NaN
name: N-acetyl-D-mannosamine
type: Species
boundary condition: false
is: CHEBI:17122
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
has only substance units: false
is: SBO:0000247
constant: false

metaM arab L e
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
is: CHEBI:30849
constant: false
is: HMDB00646
name: L-arabinose

metaR RE1804M
modifier: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: RE1804
reversible: true
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110028#

metaM xylu L c
initial concentration: 1.0
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial amount: NaN
name: L-xylulose
is: HMDB00751
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:17399

metaR r0913
fast: false
type: Reaction
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR Uritn
reversible: true
name: uridine transport in nucleus
fast: false
reactant: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000000
type: Reaction

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM ksi pre11 g
name: keratan sulfate I biosynthesis, precursor 11
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:28067
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_8072bdbb_2000_4303_8d36_14c832b12ae2
is encoded by: hsa:6391
is: SBO:0000252
boundary condition: true
name: SDHC
has only substance units: false
is: Q99643
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_d62366e7_10e1_4e93_9f54_87bda36934ab
type: Species
is: SBO:0000252
is: Q96CD2
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:60490
name: PPCDC
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_faddc42d_20c2_4ad2_b93d_d51bec5c91b7
has only substance units: false
is encoded by: hsa:218
type: Species
is: P30838
initial concentration: NaN
is: SBO:0000252
name: ALDH3A1
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_baa81c87_dcdd_44b5_9cf9_d8b5fee976ac
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q11201
is encoded by: hsa:6482
constant: false
has only substance units: false
type: Species
name: ST3GAL1
initial amount: NaN

metaR DGK2m
product: MODEL1310110028#
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
fast: false
is: SBO:0000176
type: Reaction

metaR r0644
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
product: MODEL1310110028#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
reversible: true
is: SBO:0000176
reactant: MODEL1310110028#

metaM c226coa m
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C16169
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_312abbec_50eb_432c_8252_b897d4602455
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: PRDX2
boundary condition: true
type: Species
is encoded by: hsa:7001
initial amount: NaN

metaR PHETHPTOX2
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
modifier: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/1.14.16.1
is: SBO:0000176
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)

metaM cbasp c
type: Species
initial amount: NaN
constant: false
is: C00438
name: N-Carbamoyl-L-aspartate
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:32814
is: SBO:0000247
is: HMDB00828

metaR r1464
name: Active transport
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185

metaR Uritm
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
reversible: true
reactant: MODEL1310110028#
name: uridine facilated transport in mitochondria
product: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_0ff6323b_9b43_4295_a5ce_4894050fe740
initial concentration: NaN
is: P07205
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: PGK2
initial amount: NaN
type: Species
is encoded by: hsa:5232

http://identifiers.org/biomodels.db/MODEL1310110028#_ae24be2d_732b_4325_8f64_b1f8852f2d8a
has only substance units: false
constant: false
boundary condition: true
name: PDE1A
is encoded by: hsa:5136
type: Species
initial amount: NaN
is: P54750
is: SBO:0000252
initial concentration: NaN

metaM arab L c
is: HMDB00646
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
name: L-arabinose
is: CHEBI:30849
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a8015fe0_0475_4dcc_ae4c_d1a7e381fab4
is: SBO:0000252
type: Species
initial concentration: NaN
name: PDE5A
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8654
initial amount: NaN
is: G5E9C5

metaM hpdca c
is: CHEBI:32366
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: HMDB02259
is: SBO:0000247
name: margarate
initial amount: NaN
boundary condition: false

metaM naglc2p U c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
constant: false
boundary condition: false
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
is: CHEBI:18278
type: Species

metaR PI45P5Pn
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
reactant: MODEL1310110028#
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110028#_db4bb103_bfa2_4cae_8f8f_20b0240868d0
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80025
constant: false
name: PANK2

metaR PEAMNO
product: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.4
is version of: http://identifiers.org/ec-code/1.4.3.22
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
reactant: MODEL1310110028#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
name: Phenethylamine oxidase
is version of: http://identifiers.org/ec-code/1.4.3.21

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR GHMT2r
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
name: glycine hydroxymethyltransferase, reversible
modifier: MODEL1310110028#
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.1.2.1
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_4bb416ac_7a5a_4823_99e2_274ba948bade
has only substance units: false
is encoded by: hsa:122622
name: ADSSL1
constant: false
is: Q8N142
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r1578
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
fast: false
type: Reaction

metaM asp L m
is: SBO:0000247
constant: false
name: L-aspartate(1-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
type: Species
is: HMDB00191
is: CHEBI:29991

metaR CHSTEROLtrc
type: Reaction
product: MODEL1310110028#
fast: false
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
reversible: true
name: transport of cholesterol into the cytosol

metaR FAOXC225C204x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaR FUMSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#
name: Fumarate:sulfite antiport, mitochondrial
type: Reaction
modifier: MODEL1310110028#
reversible: true
product: MODEL1310110028#
fast: false

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM odecoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
type: Species
is: HMDB01322
initial amount: NaN
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57387

metaM ksii core4 deg3 l
initial concentration: 1.0
name: keratan sulfate II (core 4-linked), degradation product 3
is: HMDB00143
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110028#_121f6c7f_290c_46a6_b6ac_fcfb5c6ee04e
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:9926
initial concentration: NaN
has only substance units: false
name: LPGAT1
is: Q92604
type: Species
is: SBO:0000252

metaR r2509
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
kinetic law: MODEL1310110028#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
name: Utilized transport
product: MODEL1310110028#
is described by: ECO:0000000
fast: false

metaM focytC m
name: Ferrocytochrome C
has only substance units: false
is: CHEBI:16928
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124

http://identifiers.org/biomodels.db/MODEL1310110028#_3f9a258d_0250_4baf_8dd8_eae10c5d0211
type: Species
is encoded by: hsa:8879
is: SBO:0000252
is: O95470
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: SGPL1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_b96d4372_0900_43ba_ba11_32d1214bf68f
type: Species
is encoded by: hsa:1609
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: DGKQ
initial concentration: NaN
is: P52824

metaR r1466
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
name: EC:2.3.1.86
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_9ea51a99_0018_4892_aeb1_a3f102f95d0d
is encoded by: hsa:55568
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: GALNT10

metaR r1579
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110028#

metaM hexe3coa m
is: HMDB06522
type: Species
name: 3-hexenoylcoa
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_6352618a_f1e7_4cfc_b0aa_4d54feda39ea
initial concentration: NaN
initial amount: NaN
name: SLC4A8
has only substance units: false
is: SBO:0000252
is: E7EML0
is encoded by: hsa:9498
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_07d80def_2d1b_446b_886a_3ece0d4da0f7
initial concentration: NaN
has only substance units: false
is: Q9BZX2
is: SBO:0000252
boundary condition: true
name: UCK2
type: Species
initial amount: NaN
is encoded by: hsa:7371
constant: false

metaR SUBERCROT
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaM ksi pre14 g
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 14
constant: false
type: Species
is: CHEBI:28067
boundary condition: false
is: SBO:0000247
notes: FORMULA: C143H230N10O114S4X CHARGE: -5

metaR PI4PLC
name: phosphatidylinositol 4-phosphate phospholipase C
reversible: false
product: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110028#

metaM citr L m
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
is: HMDB00904
has only substance units: false
type: Species
is: CHEBI:16349
is: SBO:0000247
name: L-citrulline

http://identifiers.org/biomodels.db/MODEL1310110028#_a386bb5d_c425_4afe_97aa_8a4e79b52896
name: GALT
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2592
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: B4E097

http://identifiers.org/biomodels.db/MODEL1310110028#_611bae21_a0c8_4403_abfb_8ce6a2d2a36f
initial concentration: NaN
type: Species
name: SLC25A10
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:1468
initial amount: NaN
is: SBO:0000252
is: Q9UBX3

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR GLUtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
reversible: true
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000185
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
name: intracellular transport

metaM l2n2m2mn l
constant: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: HMDB00143
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:12936

metaR FAS120COA
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
modifier: MODEL1310110028#
name: fatty-acyl-CoA synthase (n-C12:0CoA)
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
product: MODEL1310110028#
is described by: ECO:0000269

metaM dgdp c
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP
boundary condition: false
has only substance units: false
is: HMDB00960
is: SBO:0000247
initial concentration: 1.0
is: C00361
is: CHEBI:58595
type: Species

metaR GLCtg
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
fast: false
is described by: ECO:0000269
name: glucose transport, Golgi apparatus
reactant: MODEL1310110028#

metaR r2507
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
name: Utilized transport
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_562ac3a7_d397_43a3_a1a7_86d6daac05fb
has part: Q9BRB3
type: Species
is encoded by: hsa:5277
is encoded by: hsa:51227
is encoded by: hsa:9091
has part: B3KUV7
is encoded by: hsa:5279
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:8818
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: Q92535
is: SBO:0000297
is encoded by: hsa:5283
has part: Q14442
has part: O94777

http://identifiers.org/biomodels.db/MODEL1310110028#_6559cc1c_fb82_4163_afed_8b01f5b85964
name: TM7SF2
boundary condition: true
initial amount: NaN
is encoded by: hsa:7108
constant: false
is: O76062
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110028#_e1cec3f3_c418_46bb_9cd6_58be92e8b0b1
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
name: RPN1
initial amount: NaN
is encoded by: hsa:6184
boundary condition: true
has only substance units: false
is: P04843

metaM 3pg c
is: HMDB00807
is: http://identifiers.org/pubchem.compound/3497
is: CHEBI:58272
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: C00197
name: 3-Phospho-D-glycerate
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM ac m
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: HMDB00042
is: SBO:0000247
is: CHEBI:30089
name: acetate
initial amount: NaN
has only substance units: false

metaR LALDO
modifier: MODEL1310110028#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
product: MODEL1310110028#

metaR r0647
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reversible: true
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
name: Spontaneous reaction
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_b99889ad_2a98_47bf_9a7e_4e6ec5c68413
has only substance units: false
is encoded by: hsa:117247
name: SLC16A10
is: Q8TF71
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR ALAt2r
fast: false
name: L-alanine reversible transport via proton symport
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reversible: true
product: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR CHOLK
is described by: ECO:0000269
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.1.32
type: Reaction
reactant: MODEL1310110028#
reversible: false
modifier: MODEL1310110028#
fast: false
name: Choline kinase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR PIACGT
kinetic law: MODEL1310110028#
name: phosphatidylinositol N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.198
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.83
reactant: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
modifier: MODEL1310110028#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_509983bf_5eb5_47f4_a766_721a4283561a
type: Species
constant: false
is: Q8TCD5
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:30833
name: NT5C
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_cd960280_8b71_49bf_9e27_7ce1c4383b99
is encoded by: hsa:5137
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is: Q8NB10
name: PDE1C
constant: false
initial concentration: NaN

metaR r2506
is: SBO:0000185
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
is described by: ECO:0000000
name: Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
reactant: MODEL1310110028#

metaR XOL7AONEtr
name: lipid, flip-flop intracellular transport
fast: false
reversible: true
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110028#

metaM 6dhf e
initial amount: NaN
name: hexaglutamyl folate (DHF)
boundary condition: false
is: HMDB06563
type: Species
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247

metaR PMANM
is version of: http://identifiers.org/ec-code/5.4.2.2
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.4.2.8
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
name: phosphomannomutase

http://identifiers.org/biomodels.db/MODEL1310110028#_f3ae2e40_901c_472b_a5f6_7d74fc83bd96
type: Species
is encoded by: hsa:83715
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: B1AK53
constant: false
name: ESPN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_2396ba1a_753d_4565_bad7_cb84804586bc
is encoded by: hsa:5291
initial amount: NaN
is: B4DER4
is: SBO:0000252
boundary condition: true
constant: false
name: PIK3CB
has only substance units: false
initial concentration: NaN
type: Species

metaM lgnc c
is: SBO:0000247
is: HMDB02003
constant: false
is: CHEBI:31014
has only substance units: false
initial amount: NaN
type: Species
name: lignocerate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547

http://identifiers.org/biomodels.db/MODEL1310110028#_987e7e91_920b_4510_83f1_c9af88ab4589
is: A8K3T7
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:27159
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: CHIA

metaR PHCDm
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110028#
reversible: false
kinetic law: MODEL1310110028#
fast: false
type: Reaction
reactant: MODEL1310110028#
is: SBO:0000176
product: MODEL1310110028#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD

metaR r2534
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaM lneldccoa m
initial amount: NaN
is: HMDB01064
constant: false
type: Species
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
initial concentration: 1.0
name: linoelaidyl coenzyme A
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164

metaM glcur e
initial amount: NaN
boundary condition: false
is: CHEBI:15748
initial concentration: 1.0
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: SBO:0000247
constant: false
is: HMDB00127
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_d0908465_f475_41be_87dc_57640d477588
boundary condition: true
initial amount: NaN
is encoded by: hsa:8733
is: SBO:0000252
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: GPAA1
is: O43292

http://identifiers.org/biomodels.db/MODEL1310110028#_cecef47c_5b20_4917_946a_2582f5754f4f
is: Q13123
initial amount: NaN
is encoded by: hsa:3550
type: Species
boundary condition: true
has only substance units: false
name: IK
is: SBO:0000252
initial concentration: NaN
constant: false

metaR r0651
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110028#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
fast: false

metaR RE1447N
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
product: MODEL1310110028#
reactant: MODEL1310110028#
name: RE1447
reversible: true

metaR 34HPLFM
reactant: MODEL1310110028#
name: 3-(4-hydroxyphenyl-)lactate formation
kinetic law: MODEL1310110028#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is described by: ECO:0000000
reversible: false
product: MODEL1310110028#
type: Reaction

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaM hs deg18 l
type: Species
initial amount: NaN
name: heparan sulfate, degradation product 18
is: HMDB01352
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:17180
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
constant: false
initial concentration: 1.0

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_2df4e392_c94d_429a_8f74_c81e28777578
is: SBO:0000252
has only substance units: false
name: FH
is encoded by: hsa:2271
initial amount: NaN
is: P07954
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR r0917
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110028#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110028#

metaR PRPPS
is: SBO:0000176
modifier: MODEL1310110028#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.6.1
product: MODEL1310110028#
name: phosphoribosylpyrophosphate synthetase
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110028#

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR r2535
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110028#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110028#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000

metaM core6 l
has only substance units: false
initial amount: NaN
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: HMDB00143
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:12936

metaM bilglcur c
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species
constant: false
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ee5910a6_2174_4af3_9fbe_764013219f6a
boundary condition: true
constant: false
initial amount: NaN
is: Q9UNK4
is encoded by: hsa:26279
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PLA2G2D
type: Species

metaR r0652
is: SBO:0000176
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110028#
modifier: MODEL1310110028#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is described by: ECO:0000000

metaM 13dampp c
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00002
name: trimethylenediaminium
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57484

http://identifiers.org/biomodels.db/MODEL1310110028#_6c39cbac_4728_40bb_8119_eb0114df185e
is encoded by: hsa:1809
boundary condition: true
name: DPYSL3
is: Q8IXW6
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false

metaM hco3 e
is: HMDB00595
constant: false
boundary condition: false
is: CHEBI:17544
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: C00288
is: SBO:0000247
name: Bicarbonate

http://identifiers.org/biomodels.db/MODEL1310110028#_9143d34b_9253_4d40_8a42_5738bde881bb
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: Q5I0G3
has only substance units: false
is encoded by: hsa:130752
initial amount: NaN
name: MDH1B
is: SBO:0000252

metaR RE1447M
is described by: ECO:0000000
modifier: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
product: MODEL1310110028#
fast: false
reversible: true
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.41
name: RE1447
is: SBO:0000176
kinetic law: MODEL1310110028#

metaM CE5236 n
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB03952
is: CHEBI:28002

metaM lneldc e
is: SBO:0000247
has only substance units: false
type: Species
name: linoelaidic acid (all trans C18:2)
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
is: HMDB06270

http://identifiers.org/biomodels.db/MODEL1310110028#_74b7d7f8_c757_445e_89c4_2b219b768d1d
is encoded by: hsa:10327
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: AKR1A1
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_782024b6_e2a7_47f4_a3d8_4a3871b50f2c
name: SLC5A1
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P13866
initial amount: NaN
is encoded by: hsa:6523

metaR r1731
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaM hexdicoa r
name: hexadecanedioylcoa
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: HMDB00672
is: SBO:0000247
is: C08260
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species

metaR S2TASE1ly
type: Reaction
name: iduronate-2-sulfatase, lysosomal
modifier: MODEL1310110028#
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
is described by: ECO:0000000

metaR 3MOX4HOXPGALDOX
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000304
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reversible: false

metaM lgnc e
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB02003
constant: false
is: CHEBI:31014
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
name: lignocerate
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_23106b97_8626_4efc_b8e5_b8cada9fd28a
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:94033
name: FTMT
is: Q8N4E7
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_fdfc71d2_35f7_47a8_aae7_ab837dbf47a3
initial concentration: NaN
is: P43166
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:766
has only substance units: false
is: SBO:0000252
name: CA7

http://identifiers.org/biomodels.db/MODEL1310110028#_9f48bbe6_30d6_4e4d_8dbb_f36ceafbcc71
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:158
boundary condition: true
has only substance units: false
type: Species
name: ADSL
is: SBO:0000252
constant: false

metaR r2329
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_46bb2797_0a55_448b_84cc_801563e4f553
constant: false
type: Species
initial concentration: NaN
is: Q5VYT2
is: SBO:0000252
name: NDUFB6
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4712

http://identifiers.org/biomodels.db/MODEL1310110028#_f5070c77_6c29_4631_8be2_c5267a6ca491
is encoded by: hsa:79901
has only substance units: false
is: B4DWD7
is: SBO:0000252
type: Species
name: CYBRD1
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaM hs deg7 l
type: Species
is: HMDB01352
initial amount: NaN
is: CHEBI:17180
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 7
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
is: SBO:0000247

metaM glcur c
is: HMDB00127
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
is: CHEBI:15748
type: Species
boundary condition: false
initial concentration: 1.0
name: D-glucuronate

metaR r1898
product: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0653
kinetic law: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_1d656a28_d73a_4eb0_96b6_4984124a734f
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:11182
initial amount: NaN
name: SLC2A6
type: Species
is: SBO:0000252
boundary condition: true
is: Q9UGQ3

http://identifiers.org/biomodels.db/MODEL1310110028#_32e632f0_e872_45cb_ba79_b404e409c5c1
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
name: AK2
constant: false
is: P54819
is encoded by: hsa:204
is: SBO:0000252
boundary condition: true

metaR r2001
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: false

metaR r0915
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

metaR FAOXC101x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR ACGAM6PSi
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000304
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.4
reversible: false
type: Reaction
name: N-acetylglucosamine-6-phosphate synthase
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
fast: false

metaM bilglcur e
boundary condition: false
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

metaR r2537
is: SBO:0000185
name: Utilized transport
kinetic law: MODEL1310110028#
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR r2328
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
kinetic law: MODEL1310110028#

metaR ALAGLNexR
is described by: ECO:0000304
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaM CE1925 e
is: CHEBI:57923
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3'-carboxy-alpha-chromanol
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaR TSTSTERONEt
name: Testosterone transport
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
product: MODEL1310110028#

metaM odecrn c
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
is: CHEBI:57394
initial concentration: 1.0
is: HMDB01114
is: C00412
type: Species
constant: false
boundary condition: false
name: octadecenoyl carnitine
has only substance units: false
initial amount: NaN

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR 7DHCHSTEROLtr
name: cholesterol precursor intracellular transport
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
reversible: true
reactant: MODEL1310110028#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_2e8edd1e_b508_434a_be1d_668686924864
constant: false
type: Species
name: NT5C
boundary condition: true
is encoded by: hsa:30833
has only substance units: false
initial amount: NaN
is: Q8TCD5
is: SBO:0000252
initial concentration: NaN

metaM lneldc c
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB06270
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
name: linoelaidic acid (all trans C18:2)
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247

metaR AMETtd
name: diffusion of S-Adenosyl-L-methionine
is: SBO:0000185
reactant: MODEL1310110028#
reversible: true
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_7a955527_19a7_46e7_9db1_26e8ce51023f
initial amount: NaN
is: Q6YFQ2
is: SBO:0000252
name: COX6B2
has only substance units: false
is encoded by: hsa:125965
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaR r2538
product: MODEL1310110028#
is: SBO:0000185
reversible: true
reactant: MODEL1310110028#
name: Utilized transport
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110028#

metaR SPODMn
product: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
name: superoxide dismutase, nuclear
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false
fast: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
kinetic law: MODEL1310110028#
is: SBO:0000176

metaR C161OHc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaM HC00718 c
initial concentration: 1.0
boundary condition: false
is: CHEBI:57781
name: N-methylethanolaminium phosphate(1-)
is: SBO:0000247
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM malttr e
type: Species
is: HMDB01262
initial amount: NaN
constant: false
has only substance units: false
is: C01835
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: SBO:0000247
is: CHEBI:27931
name: maltotriose
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_e853af93_267a_471d_a5df_0063588392a4
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI090874
has only substance units: false
name: _AI090874_1_c
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_8614aa72_59cb_4768_bc39_f375bf18b1a6
type: Species
boundary condition: true
initial amount: NaN
is: Q99808
initial concentration: NaN
name: SLC29A1
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2030

metaR C4DCe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of succinyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_0c52c94c_cc7c_4d4a_bc80_4ff81fde87f4
name: DPAGT1
constant: false
has only substance units: false
is: Q9H3H5
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:1798
initial amount: NaN

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_5bb33282_3326_4b0a_8eb3_1674b6b4b601
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: FUT8
is: SBO:0000252
is encoded by: hsa:2530
boundary condition: true
initial concentration: NaN
is: Q546E0

metaR RDH3a
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.1.1.300
reactant: MODEL1310110028#
type: Reaction
reversible: true
modifier: MODEL1310110028#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.105
name: retinol dehydrogenase (11-cis,NADPH)
is described by: ECO:0000269
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT

metaM CE4794 m
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
constant: false
is: CHEBI:57923
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: cis-6-dodecenoyl-CoA
initial amount: NaN

metaR DGK1
kinetic law: MODEL1310110028#
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110028#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8
fast: false
name: deoxyguanylate kinase (dGMP:ATP)
reactant: MODEL1310110028#

metaM acrn r
is: SBO:0000247
type: Species
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
has only substance units: false
is: CHEBI:57589
is: HMDB00201
initial amount: NaN
name: O-acetylcarnitine
initial concentration: 1.0
constant: false
boundary condition: false

metaM r5p r
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: alpha-D-Ribose 5-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: SBO:0000247
is: HMDB00618
is: CHEBI:18189
type: Species
boundary condition: false
constant: false

metaR ASNtN1
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
modifier: MODEL1310110028#
name: Asparagine transport (Na, H coupled)
kinetic law: MODEL1310110028#
is described by: ECO:0000269
reactant: MODEL1310110028#

metaR r1896
kinetic law: MODEL1310110028#
reversible: false
fast: false
is: SBO:0000185
modifier: MODEL1310110028#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dtdp c
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
is: HMDB01274
is: SBO:0000247
is: C00363
name: dTDP
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110028#_85ee716c_3a19_42cb_85dd_b1880d690f8a
is encoded by: hsa:2879
name: GPX4
is: P36969
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaR FAOXC12DCx
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaM ksi deg39 l
initial concentration: 1.0
has only substance units: false
is: CHEBI:12936
boundary condition: false
name: keratan sulfate I, degradation product 39
initial amount: NaN
notes: FORMULA: C48H81N3O36 CHARGE: 0
constant: false
is: HMDB00143
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_54bcf09d_14d6_472a_9489_ff445b2119a3
initial concentration: NaN
is encoded by: hsa:4967
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: OGDH
is: Q02218
constant: false
type: Species
has only substance units: false

metaR GGH 7DHFe
reactant: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
modifier: MODEL1310110028#
product: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (7DHF), extracellular
reversible: false
type: Reaction
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_fe53b434_e478_4384_950a_31eed2d7dfd3
constant: false
initial concentration: NaN
is: B2RAU6
is encoded by: hsa:9091
type: Species
name: PIGQ
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR HSD3A1r
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
reactant: MODEL1310110028#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
modifier: MODEL1310110028#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
type: Reaction
reversible: true
product: MODEL1310110028#
kinetic law: MODEL1310110028#

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_e5890070_588b_4542_8bfc_8c05f1be3e70
type: Species
is encoded by: hsa:642502
boundary condition: true
constant: false
is: SBO:0000252
name: _642502_1_c
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_a3808b8b_3f05_4860_b015_a71d81c9e975
is encoded by: hsa:8402
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: F5GY65
constant: false
type: Species
initial amount: NaN
name: SLC25A11
has only substance units: false

metaR XYLt
is described by: ECO:0000269
reversible: true
product: MODEL1310110028#
modifier: MODEL1310110028#
name: D-xylose reversible transport
is: SBO:0000185
fast: false
reactant: MODEL1310110028#
type: Reaction
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
kinetic law: MODEL1310110028#

metaM paf hs e
constant: false
type: Species
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:36707
has only substance units: false
initial amount: NaN
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
boundary condition: false
is: SBO:0000247

metaM xtsn c
initial amount: NaN
is: HMDB00299
initial concentration: 1.0
type: Species
has only substance units: false
name: xanthosine
boundary condition: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
constant: false
is: CHEBI:18107
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_4c7da5ef_c3bc_4c34_abd7_23ac73cd12b0
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:D29675
initial amount: NaN
name: _D29675_1_e
constant: false

metaM fn2m2masn g
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
type: Species
initial amount: NaN
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:32984

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaR CRVNCtr
type: Reaction
is: SBO:0000185
product: MODEL1310110028#
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#

metaR FAOXC103C102x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaR AHC
is version of: http://identifiers.org/ec-code/3.3.1.1
modifier: MODEL1310110028#
type: Reaction
name: adenosylhomocysteinase
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000269

metaM dump n
initial amount: NaN
is: CHEBI:246422
name: dUMP(2-)
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: HMDB01409
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_a6e3a6f3_9369_40c2_93fe_b122f29e4c8d
initial amount: NaN
boundary condition: true
is encoded by: hsa:197257
name: LDHD
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: Q86WU2
is: SBO:0000252

metaR SPODMm
name: superoxide dismutase
type: Reaction
reversible: false
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
fast: false
is: SBO:0000176
kinetic law: MODEL1310110028#
is described by: ECO:0000304
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_8d30d29c_68ec_4f58_895b_86c0e4cbdec4
boundary condition: true
is: SBO:0000252
name: DPM3
is encoded by: hsa:54344
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9P2X0

metaR RE3421R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
kinetic law: MODEL1310110028#
is described by: ECO:0000000
name: RE3421
is: SBO:0000176
type: Reaction
reactant: MODEL1310110028#
reversible: true
product: MODEL1310110028#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_64354cf6_ba81_45d0_ac83_30ab60dca473
is: P14550
type: Species
has only substance units: false
name: AKR1A1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10327
is: SBO:0000252
initial amount: NaN
constant: false

metaM HC01459 x
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
is: SBO:0000247
is: CHEBI:27458

metaM thmmp c
is: HMDB02666
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:37575
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
name: Thiamin monophosphate
initial amount: NaN
is: C01081
initial concentration: 1.0
boundary condition: false

metaR 4HBZCOAFm
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
kinetic law: MODEL1310110028#
type: Reaction
fast: false
reactant: MODEL1310110028#
name: 4-hydroxybenzoyl-CoA formation
product: MODEL1310110028#
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaM dtdp e
constant: false
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB01274
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247

metaR r0650
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
reactant: MODEL1310110028#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110028#
product: MODEL1310110028#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
modifier: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110028#_f296b753_f3ce_45ac_9cd8_95d2d158fde2
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:219
is: P30837
name: ALDH1B1
is: SBO:0000252
type: Species
constant: false

metaM retinal cis 9 r
is: CHEBI:17898
name: all-trans-retinal
is: HMDB01358
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_3b4a5e8f_dc27_4c86_9954_bda1d028fdf4
type: Species
initial amount: NaN
is encoded by: hsa:217
name: ALDH2
is: P05091
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaR GLCURtly
reactant: MODEL1310110028#
product: MODEL1310110028#
name: glucuronate transport into lysososme
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110028#
fast: false
reversible: true
kinetic law: MODEL1310110028#

metaR GALASE15ly
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
fast: false
reactant: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR INSTt4
reactant: MODEL1310110028#
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110028#
name: inositol transport via sodium symport
product: MODEL1310110028#
type: Reaction

metaM ksii core4 pre10 g
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:28067
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 10

metaM HC02205 e
is: SBO:0000247
is: CHEBI:28099
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2

metaR DNDPt10m
kinetic law: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110028#
fast: false
type: Reaction
name: dADP transport via dCDP antiport

metaR RE3003M
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
product: MODEL1310110028#
modifier: MODEL1310110028#
is: SBO:0000176
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
name: RE3003

http://identifiers.org/biomodels.db/MODEL1310110028#_c30440e4_bac3_41b2_8f38_67cdd27b303a
name: MECR
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:51102
initial concentration: NaN
type: Species
is: Q9BV79
has only substance units: false

metaM 34dhmald c
name: 3,4-Dihydroxymandelaldehyde
is: http://identifiers.org/pubchem.compound/7903
is: C05577
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_ad336fa1_6520_46fa_b7ac_7b614f0aecbf
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:5281
initial concentration: NaN
type: Species
is: SBO:0000252
name: PIGF
is: Q07326

metaR r1008
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110028#
is: SBO:0000185
type: Reaction
name: Facilitated diffusion
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110028#

metaR r2323
kinetic law: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110028#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110028#

metaR FAOXC181C161x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaM ocdececrn c
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: HMDB06351
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
name: 11-octadecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110028#_34ba0cf4_833d_42f2_bdb2_083f49ae19b8
boundary condition: true
is: P49915
type: Species
name: GMPS
initial amount: NaN
constant: false
is encoded by: hsa:8833
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_0a734d55_5563_4580_afcf_abca10a7cca0
has only substance units: false
type: Species
name: LDHA
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3939
is: P00338
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_815d1f8b_ffc3_4ea9_9f13_04a877620534
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
name: HPRT1
is: P00492
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3251

metaM ksi deg24 l
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
constant: false
is: HMDB00143
type: Species
has only substance units: false
name: keratan sulfate I, degradation product 24
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110028#_ba61a02b_690f_4679_9511_3f50561d9a7f
has only substance units: false
is: SBO:0000252
is: Q308M7
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: ENPP3
is encoded by: hsa:5169
initial amount: NaN

metaM 6hoxmelatn c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7954
name: 6-Hydroxymelatonin
is: HMDB04081
has only substance units: false
type: Species
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
initial amount: NaN
boundary condition: false
is: C05643
constant: false
initial concentration: 1.0

metaR MMSAD3m
is: SBO:0000176
reversible: false
reactant: MODEL1310110028#
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
fast: false
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.2.1.27
type: Reaction
is described by: ECO:0000269
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_c407bf61_55a4_4c13_bd0a_da5f7c675710
is: O75355
constant: false
initial concentration: NaN
has only substance units: false
name: ENTPD3
type: Species
is encoded by: hsa:956
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR GK1
is described by: ECO:0000269
product: MODEL1310110028#
fast: false
name: guanylate kinase (GMP:ATP)
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.4.8
modifier: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR r2322
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_412e04b2_cb1e_4bab_b78f_442ea4232d7e
is encoded by: hsa:79646
has only substance units: false
boundary condition: true
constant: false
is: Q9H999
name: PANK3
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaM HC01522 c
constant: false
is: CHEBI:28508
is: SBO:0000247
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
name: Gentisate aldehyde
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN

metaR EX but LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Butyrate (n-C4:0) exchange
type: Reaction

metaM CE5236 c
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28002
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952
is: SBO:0000247

metaR UGLT
is described by: ECO:0000000
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
reactant: MODEL1310110028#
is: SBO:0000176
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110028#
fast: false
type: Reaction
name: UDPglucose--hexose-1-phosphate uridylyltransferase
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_5c1410c7_87ed_44f1_99bd_30e9761f2061
name: NME1
type: Species
is encoded by: hsa:4830
is: P15531
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false

metaM gmp c
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58115
initial concentration: 1.0
is: C00144
initial amount: NaN
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
name: GMP
is: HMDB01397

metaR r2321
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_cc782db8_1406_42f6_9dee_9551990dafa7
is encoded by: hsa:6389
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: SDHA
type: Species
is: SBO:0000252
is: P31040

http://identifiers.org/biomodels.db/MODEL1310110028#_39ad57ee_e888_40f3_8075_81b455ab3c81
type: Species
is encoded by: hsa:23236
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: PLCB1
has only substance units: false

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR r0208
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reactant: MODEL1310110028#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
modifier: MODEL1310110028#
type: Reaction
is version of: http://identifiers.org/ec-code/4.4.1.1
kinetic law: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
fast: false

metaR ALDD21
is: SBO:0000176
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
type: Reaction
fast: false
product: MODEL1310110028#
is described by: ECO:0000304
modifier: MODEL1310110028#
reversible: false
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (pristanal, NAD)

metaR GALt4
modifier: MODEL1310110028#
product: MODEL1310110028#
reversible: true
reactant: MODEL1310110028#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
kinetic law: MODEL1310110028#
fast: false
name: galactose transport via sodium symport

metaR FAOXC102C101x
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_6f53e69a_e57e_44c7_8b3a_cce1841a38b3
name: UCKL1
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q53HM1
is encoded by: hsa:54963
constant: false

http://identifiers.org/biomodels.db/MODEL1310110028#_4a5910e6_00ca_416b_881c_ee5e2a894e98
name: MTMR2
type: Species
is encoded by: hsa:8898
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: A6NN98
is: SBO:0000252

metaR r2320
reversible: true
type: Reaction
product: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110028#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110028#_615603d5_1261_45e1_bd4a_f93ca5ca66fb
name: _286297_1_c
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:286297
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_b4546f56_fb34_4760_8a6a_428b06289852
is encoded by: hsa:2987
initial concentration: NaN
constant: false
name: GUK1
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q16774
type: Species
is: SBO:0000252

metaR ACACT10m
reactant: MODEL1310110028#
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
modifier: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110028#
is: SBO:0000176
is described by: ECO:0000134

metaM tddedi2coa m
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00792
name: trans2,6dodecadienoylcoa
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
type: Species
is: C08277
constant: false

metaR PTDCACRNCPT2
reactant: MODEL1310110028#
reversible: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
product: MODEL1310110028#
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: pentadecanoate transport into the mitochondria
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000

metaM no c
is: CHEBI:16480
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: HMDB03378
name: Nitric oxide
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: C00533
boundary condition: false

metaM retinol cis 11 c
boundary condition: false
is: SBO:0000247
is: HMDB06216
is: CHEBI:16302
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
has only substance units: false
type: Species
name: 11-cis-retinol
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_3e013d39_a701_40dc_83c6_5c3ddfffa6d0
has only substance units: false
is: SBO:0000252
type: Species
name: PPAT
is encoded by: hsa:5471
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: Q06203

metaR KYNAKGAT
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.6.1.64
name: L-Kynurenine:2-oxoglutarate aminotransferase
modifier: MODEL1310110028#

metaM memgacpail hs r
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:15809
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ed2c2494_46cb_4af8_b6d8_e521b8ed2739
constant: false
name: SLC38A1
is encoded by: hsa:81539
is: SBO:0000252
has only substance units: false
is: Q9H2H9
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r2327
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110028#
product: MODEL1310110028#

metaR r2113
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
modifier: MODEL1310110028#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR r1593
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110028#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110028#
fast: false
is: SBO:0000185

metaR FAOXC103C102m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_cb0ec80b_3f94_4760_ae7d_8a3db77165a9
is: Q59F77
initial amount: NaN
is encoded by: hsa:5330
name: PLCB2
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR CYSTGLUex
name: L-cystine/L-glutamate exchanger
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
is described by: ECO:0000269
modifier: MODEL1310110028#
is: SBO:0000185
product: MODEL1310110028#
fast: false
reversible: false
type: Reaction

metaR BILIRUBtr
reactant: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
is: SBO:0000185
kinetic law: MODEL1310110028#
reversible: true
product: MODEL1310110028#
name: lipid, flip-flop intracellular transport
type: Reaction

metaR EX c10crn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

metaR PTDCACRNCPT1
type: Reaction
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine fatty-acyl transferase
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
fast: false
product: MODEL1310110028#
is described by: ECO:0000269
is: SBO:0000176
reversible: false

metaM gmp e
is: CHEBI:58115
is: SBO:0000247
is: HMDB01397
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: GMP(3-)
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
constant: false

metaM gsn c
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
boundary condition: false
is: C00387
is: CHEBI:16750
name: Guanosine
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00133

metaR SUCCTD
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM 2dodtricoa x
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
name: 2,6,9-dodecatrienoylcoa
is: C05279
boundary condition: false
is: HMDB11123
initial amount: NaN

metaR EX c8crn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

metaR r2326
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110028#
fast: false
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM dd2coa c
is: SBO:0000247
name: trans-Dodec-2-enoyl-CoA
is: HMDB03712
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
constant: false
type: Species

metaR 3DPHBH1
is: SBO:0000176
name: Hydroxylation of 3-Decaprenyl-4-hydroxybenzoate (NADH)
reactant: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212 NOTES:Used to make Ubiquinone-10 enzyme has not been identified yet. IT
kinetic law: MODEL1310110028#
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110028#

metaR r1592
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_95da259a_0517_4a45_8e6d_50a6a106cde5
constant: false
type: Species
is encoded by: hsa:4723
is: SBO:0000252
has only substance units: false
name: NDUFV1
initial amount: NaN
is: E5KNH5
boundary condition: true
initial concentration: NaN

metaR FAOXC225C204m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_ee59da58_d7cd_4f3f_b7cf_6c8ce3c54041
name: _AV717590_1_m
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AV717590
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_ea106bf5_f650_4f50_bcb7_5a560c0ea8d2
boundary condition: true
is: SBO:0000252
name: _AW299740_1_m
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AW299740
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110028#_ee2fb61e_1e3a_43a4_8ae1_1eded45c9e7d
name: ALDH9A1
initial amount: NaN
boundary condition: true
is: P49189
is encoded by: hsa:223
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

metaR r2112
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110028#
reversible: true
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
fast: false
product: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110028#_7c1584a9_919f_4a8c_b645_072c2d93384d
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ALPP
constant: false
is encoded by: hsa:250
is: P05187
initial concentration: NaN
type: Species

metaM dtdp n
is: CHEBI:58369
is: HMDB01274
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false

metaM CE5586 c
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
type: Species
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:58732
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_4569141d_09b6_4b3a_a77c_05eac8882da2
constant: false
name: SLC14A1
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6563
initial amount: NaN
has only substance units: false
is: G0W2N5

http://identifiers.org/biomodels.db/MODEL1310110028#_4e06066b_ff06_4bad_b900_292955a3072a
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: C9JFZ1
type: Species
is encoded by: hsa:8867
initial concentration: NaN
is: SBO:0000252
name: SYNJ1

metaM no e
has only substance units: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
constant: false
is: C00533
is: CHEBI:16480
is: HMDB03378
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: Nitric oxide
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_0fe64833_86c8_424e_8d6f_774c2beea49f
is encoded by: hsa:11136
constant: false
name: SLC7A9
is: P82251
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_714264ce_f99b_494d_8e52_b3f495b1f0cf
is: P46459
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4905
is: SBO:0000252
constant: false
boundary condition: true
name: NSF
initial amount: NaN

metaR FAOXTC162TC142m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C16:2-->C14:2)m
type: Reaction

metaR r2325
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185
product: MODEL1310110028#
fast: false
type: Reaction
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaR r2532
kinetic law: MODEL1310110028#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
reversible: true
type: Reaction
is described by: ECO:0000000

metaM tethex3coa c
boundary condition: false
has only substance units: false
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
is: C16168
name: tetracosahexaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205478
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB06243
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_fc64f507_c61b_432e_9e8e_0ac8e93b9b63
boundary condition: true
is: Q9HBH5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:57665
has only substance units: false
initial amount: NaN
name: RDH14
type: Species
constant: false

metaR r1591
product: MODEL1310110028#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185

metaR EX 3hexdcrn
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

metaR r2111
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110028#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#

metaM ksi pre34 g
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:58053
is: HMDB00175
is: C00130
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
name: keratan sulfate I biosynthesis, precursor 34
constant: false
has only substance units: false
is: SBO:0000247

metaR RE0915E
fast: false
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
name: RE0915
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110028#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110028#_12f94bec_3bff_4809_8e79_887427b4bb9b
boundary condition: true
is encoded by: hsa:5148
initial amount: NaN
has only substance units: false
has part: P18545
initial concentration: NaN
is encoded by: hsa:5147
is: SBO:0000297
constant: false
type: Species
has part: O43924
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B

metaR GUAPRT
reversible: false
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.4.2.8
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
name: guanine phosphoribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110028#_45874cca_1724_4aa0_977e_830e61a90051
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:100287639
name: _100287639_1_c

http://identifiers.org/biomodels.db/MODEL1310110028#_defdc6f2_e140_46c8_8c26_367b014ab957
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:7086
is: SBO:0000252
name: TKT
is: E7EPA7
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_9ddea708_d6dd_4ee2_bdca_3f2d9ca49fb9
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:5860
is: SBO:0000252
name: QDPR
is: P09417
boundary condition: true
initial concentration: NaN
constant: false

metaM dtdp m
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: C00363
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58369

http://identifiers.org/biomodels.db/MODEL1310110028#_bc2b706f_51cd_41e7_8acd_907dc28d5a2b
type: Species
is encoded by: hsa:8525
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: B7Z6M3
name: DGKZ
constant: false

metaR FACOAL184
reversible: true
reactant: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
name: fatty-acid--CoA ligase
fast: false
type: Reaction
product: MODEL1310110028#

metaM gmp g
is: CHEBI:58115
is: SBO:0000247
is: HMDB01397
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: GMP(3-)
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

metaR FUCASE2e
product: MODEL1310110028#
modifier: MODEL1310110028#
reversible: false
reactant: MODEL1310110028#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
name: alpha-fucosidase, extracellular
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_51bd4080_e7fb_4c3a_b905_dc83e750fa6b
type: Species
has only substance units: false
is encoded by: hsa:27115
is: Q9NP56
constant: false
name: PDE7B
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM hco3 c
is: C00288
constant: false
is: HMDB00595
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
name: Bicarbonate
boundary condition: false
is: CHEBI:17544

metaM gsn e
is: SBO:0000247
constant: false
is: HMDB00133
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial amount: NaN
has only substance units: false
boundary condition: false
name: Guanosine
initial concentration: 1.0
is: C00387
is: CHEBI:16750
type: Species

metaR r2324
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110028#
is: SBO:0000185
reactant: MODEL1310110028#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110028#
type: Reaction

metaR LEUPHELAT2tc
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR r1590
reactant: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction

metaR FAEL183
product: MODEL1310110028#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reversible: false
modifier: MODEL1310110028#
is described by: ECO:0000000
name: fatty-acyl-CoA elongation (n-C18:3CoA)
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#

metaR r2110
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110028#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110028#_49551edd_17fd_47a6_9452_d441b6cea444
boundary condition: true
is encoded by: hsa:8789
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: FBP2
initial concentration: NaN
is: O00757

metaM clpndcoa x
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C16166
is: HMDB06267
is: http://identifiers.org/pubchem.compound/47205476
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial amount: NaN
initial concentration: 1.0
constant: false
name: clupanodonyl CoA
type: Species

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM acrn x
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
constant: false
is: CHEBI:57589
initial concentration: 1.0
name: O-acetylcarnitine
is: HMDB00201
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r0355
kinetic law: MODEL1310110028#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110028#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.3

metaR r0202
is: SBO:0000176
kinetic law: MODEL1310110028#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110028#_6a368a02_d07e_40f0_84cc_a59d4e2b329f
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: _AI620219_1_c
initial amount: NaN
is encoded by: hsa:AI620219
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_ce53f09e_9de6_466b_a888_d885f4e97181
initial concentration: NaN
is encoded by: hsa:498
constant: false
is: SBO:0000297
has part: B4DY56
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E

metaM 3hdeccoa m
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: HMDB02288
name: 3-hydroxyhexadecenoylcoa
notes: FORMULA: C37H60N7O18P3S CHARGE: -4

metaM dudp c
type: Species
is: SBO:0000247
constant: false
is: CHEBI:60471
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: C01346
name: dUDP
initial concentration: 1.0

metaR FAOXC102C101m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR FAOXC165C164m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR r1584
is described by: ECO:0000000
type: Reaction
product: MODEL1310110028#
reactant: MODEL1310110028#
kinetic law: MODEL1310110028#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r2104
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110028#
modifier: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
kinetic law: MODEL1310110028#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_95090b34_cce2_4b3d_83b1_f7315e319be3
initial concentration: NaN
name: _AI348006_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AI348006
initial amount: NaN
constant: false
type: Species

metaM thmmp m
is: CHEBI:37575
boundary condition: false
type: Species
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
initial amount: NaN
constant: false
initial concentration: 1.0
name: thiamine(1+) monophosphate(2-)
is: SBO:0000247
has only substance units: false
is: HMDB02666

metaM adrn c
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
name: adrenic acid
boundary condition: false
is: CHEBI:53487
has only substance units: false
type: Species

metaR C120CPT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanoylcarnitine
type: Reaction

metaR LNLCCPT2
kinetic law: MODEL1310110028#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
reactant: MODEL1310110028#
type: Reaction
modifier: MODEL1310110028#
product: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_d047b91a_07d4_435a_b31f_8b739e823d56
name: SLC5A7
is encoded by: hsa:60482
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: Q9GZV3
boundary condition: true

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_425c6826_3e7d_491b_aaf9_69f540a3192f
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: PDE9A
type: Species
is encoded by: hsa:5152
initial concentration: NaN

metaR ACCOAC
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR r0354
fast: false
reactant: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
kinetic law: MODEL1310110028#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
modifier: MODEL1310110028#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR DDCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaR r1585
kinetic law: MODEL1310110028#
fast: false
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_e5080a11_012e_498a_947a_1c5a5f2cf447
name: _D29675_1_c
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:D29675
type: Species

metaR r2105
is: SBO:0000185
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_dc07683a_4209_4233_baeb_9ef4a7e136ec
is encoded by: hsa:56922
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: Q96RQ3
initial concentration: NaN
name: MCCC1
constant: false

metaM 5adtststerones c
initial concentration: 1.0
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB06278
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
has only substance units: false

metaR C40CPT1
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM 2obut m
constant: false
name: 2-oxobutanoate
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00005
is: CHEBI:16763
initial concentration: 1.0
has only substance units: false

metaM CE2418 m
type: Species
constant: false
is: HMDB11123
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: SBO:0000247
has only substance units: false
is: CHEBI:28387
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110028#_997eedb9_4bcf_43db_890a_74e9a7de09b2
is: O00462
name: MANBA
is: SBO:0000252
is encoded by: hsa:4126
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110028#_2ad3695d_ffb0_4a3e_bfee_4fcc388c1b8a
boundary condition: true
initial concentration: NaN
name: _T83654_1_e
has only substance units: false
constant: false
is encoded by: hsa:T83654
type: Species
initial amount: NaN
is: SBO:0000252

metaR METS
reversible: false
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
modifier: MODEL1310110028#
reactant: MODEL1310110028#
product: MODEL1310110028#
name: methionine synthase
fast: false
type: Reaction
kinetic law: MODEL1310110028#
is version of: http://identifiers.org/ec-code/2.1.1.13

metaR PA HStn
fast: false
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: true
name: phosphatidate transport, nuclear
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000000
is: SBO:0000185

metaR TMNDNCCRNt
product: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
fast: false
reactant: MODEL1310110028#
name: transport into the mitochondria (carnitine)
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_c50aec0f_1836_4996_9ccc_b8a7ad0cd76f
is: P36021
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC16A2
initial amount: NaN
is encoded by: hsa:6567
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110028#_07e9d129_1791_4a7c_8428_27f432d88761
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AL048840
boundary condition: true
name: _AL048840_1_c
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaR r2102
type: Reaction
fast: false
product: MODEL1310110028#
modifier: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR TDCRNe
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_7ed33d8d_96f2_40cb_a5cc_47e5338600eb
name: IDS
constant: false
type: Species
is: SBO:0000252
is: B4DGD7
is encoded by: hsa:3423
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM adrn e
initial amount: NaN
is: HMDB02226
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:53487
name: adrenic acid
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110028#_cc054148_1bc8_43fb_888f_684f309a7a0f
initial concentration: NaN
type: Species
name: CTH
constant: false
is: SBO:0000252
boundary condition: true
is: P32929
has only substance units: false
is encoded by: hsa:1491
initial amount: NaN

metaM 2dp6mobq m
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:50773
initial amount: NaN
is: SBO:0000247
constant: false
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+

http://identifiers.org/biomodels.db/MODEL1310110028#_1c9c044d_d9ce_42ff_9fb3_718a229650cc
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4718
is: Q549M5
name: NDUFC2

metaR PROt4 2 r
is described by: ECO:0000006
type: Reaction
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110028#
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reversible: true
name: Proline transport (sodium symport) (2:1)
is: SBO:0000185
fast: false

metaR CYTK12n
modifier: MODEL1310110028#
reversible: true
fast: false
product: MODEL1310110028#
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
name: cytidylate kinase (dCMP,dCTP),nuclear

metaR r1010
kinetic law: MODEL1310110028#
is described by: ECO:0000000
product: MODEL1310110028#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110028#
reversible: true
is: SBO:0000185
fast: false
type: Reaction

metaR TTDCRNt
is described by: ECO:0000000
modifier: MODEL1310110028#
reactant: MODEL1310110028#
name: transport into the mitochondria (carnitine)
type: Reaction
reversible: false
kinetic law: MODEL1310110028#
product: MODEL1310110028#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110028#_d8e650e3_7cf0_4458_b702_8bbd1c624e69
constant: false
boundary condition: true
initial concentration: NaN
is: Q9UBM1
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10400
name: PEMT

metaR CHOLtn
is: SBO:0000185
is described by: ECO:0000000
name: Choline transport, nuclear through pores
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
kinetic law: MODEL1310110028#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
fast: false

metaR r2103
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110028#
reactant: MODEL1310110028#
fast: false
modifier: MODEL1310110028#
reversible: true
type: Reaction
product: MODEL1310110028#

http://identifiers.org/biomodels.db/MODEL1310110028#_72fdfeb4_4e62_4f04_9ba8_352c9e25d16d
is encoded by: hsa:3074
is: SBO:0000252
initial concentration: NaN
name: HEXB
is: P07686
constant: false
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR r1583
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR FAOXC164C143m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaM 5adtststerones e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB06278

http://identifiers.org/biomodels.db/MODEL1310110028#_7ff6e2e4_1187_4eb3_a979_75a1e7d83773
initial amount: NaN
is: B3KWF4
name: GALNT11
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:63917
is: SBO:0000252
constant: false

metaR FAOXC123m
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110028#_cdfdc909_6b3c_4517_ab58_43bb925dfce5
boundary condition: true
is: Q02742
constant: false
initial concentration: NaN
is encoded by: hsa:2650
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: GCNT1

metaR HTDCACBP
kinetic law: MODEL1310110028#
product: MODEL1310110028#
reactant: MODEL1310110028#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR r2108
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110028#
kinetic law: MODEL1310110028#
reversible: true
product: MODEL1310110028#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110028#
type: Reaction

metaR CHOLtu
name: Choline uniport
modifier: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
reactant: MODEL1310110028#
type: Reaction
kinetic law: MODEL1310110028#
fast: false
reversible: true
product: MODEL1310110028#
is described by: ECO:0000269

metaM lthstrl r
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: 5alpha-cholest-7-en-3beta-ol
is: HMDB01170
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: CHEBI:17168

metaM 3ttetddcoa m
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB02014
name: 3-hydroxy trans5,8tetradecadienoyl coa

metaR r1435
name: Transport reaction
type: Reaction
reactant: MODEL1310110028#
fast: false
product: MODEL1310110028#
is described by: ECO:0000000
kinetic law: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110028#_2822e9f3_2bbb_4948_baef_2ae7877ac9c2
is encoded by: hsa:144195
constant: false
initial concentration: NaN
is: Q8TDB8
type: Species
has only substance units: false
name: SLC2A14
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR DALAt2r
product: MODEL1310110028#
is described by: ECO:0000304
type: Reaction
name: D-alanine transport via proton symport
reactant: MODEL1310110028#
reversible: true
modifier: MODEL1310110028#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
kinetic law: MODEL1310110028#
is: SBO:0000185

metaR AACOAT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.16
reactant: MODEL1310110028#
type: Reaction
product: MODEL1310110028#
fast: false
kinetic law: MODEL1310110028#
is: SBO:0000176
name: Acetoacetyl-CoA:acetate CoA-transferase
reversible: true
modifier: MODEL1310110028#
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD

metaM hexdpencoa x
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
boundary condition: false
is: HMDB02288
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
name: 2,4,7,10,13-hexadecapentaenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110028#_14c2e79f_774c_4275_ae40_45cc33a898ad
constant: false
type: Species
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false
is encoded by: hsa:513
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:514
boundary condition: true
initial amount: NaN

metaR r2330
type: Reaction
reversible: true
product: MODEL1310110028#
reactant: MODEL1310110028#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110028#
fast: false

W3 CDTF: Thu Aug 30 20:20:41 BST 2012