metaR r0661
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reversible: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_52d243b8_7061_4e88_b7fe_6226acce4d6b
initial amount: NaN
is: O95497
name: VNN1
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8876
has only substance units: false

metaM arachdcoa c
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
name: arachidonoyl-CoA(4-)
is: HMDB06523
is: CHEBI:57368

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_43e2fda6_d789_4428_82ec_1ed22220d500
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:1345
name: COX6C
is: P09669
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR r1257
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
name: EC:6.2.1.3
fast: false
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reversible: false
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR DOPAt4 2 r
fast: false
reactant: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
name: Dopamine reversible transport in via sodium symport (1:2)
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110021#_eea32cef_968a_4a19_9e34_8b5786fd8f4c
name: ENPP1
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: P22413
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:5167

metaR GLCAASE9ly
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110021#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1831e1d8_3825_4c63_83f8_f18e57faf213
is: SBO:0000252
constant: false
name: _AI971036_1_x
is encoded by: hsa:AI971036
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_a8b5f595_e4f4_476f_824c_132bab1f46e1
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:AA081045
name: _AA081045_1_m

metaR EX ins LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Inosine exchange
type: Reaction

metaR O16G1e
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.10
modifier: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular

http://identifiers.org/biomodels.db/MODEL1310110021#_3369531c_0c98_4426_8da4_9c4121cfbd72
is: B7Z5T8
initial concentration: NaN
is encoded by: hsa:1375
initial amount: NaN
name: CPT1B
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaR r2520
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#

metaM 3oddcoa x
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:27868
initial amount: NaN
boundary condition: false
name: 3-Oxododecanoyl-CoA
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_b45e467b_7f3b_4886_bde6_b4702c977308
boundary condition: true
is: Q8NEM3
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9194
name: SLC16A7
constant: false
initial amount: NaN
is: SBO:0000252

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR r2521
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#
name: Utilized transport
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reversible: true
is: SBO:0000185

metaM dhcholestancoa r
boundary condition: false
is: CHEBI:15494
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB02159
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_906a3738_4431_4723_b888_c37c2bd5c6aa
boundary condition: true
type: Species
has only substance units: false
name: HADHB
initial amount: NaN
is encoded by: hsa:3032
constant: false
is: P55084
initial concentration: NaN
is: SBO:0000252

metaM co2 x
is: HMDB01967
has only substance units: false
is: SBO:0000247
is: CHEBI:16526
initial amount: NaN
name: carbon dioxide
type: Species
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
initial concentration: 1.0

metaM spmd c
is: C00315
initial concentration: 1.0
boundary condition: false
name: Spermidine
type: Species
is: CHEBI:57834
has only substance units: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: HMDB01257
constant: false
initial amount: NaN
is: SBO:0000247

metaM methf c
boundary condition: false
is: HMDB01354
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: C00445
is: SBO:0000247
name: 5,10-Methenyltetrahydrofolate
constant: false
is: CHEBI:57455
type: Species

metaR NACASPtm
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
fast: false
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#

metaM CE2705 c
name: quinonoid dihydrobiopterin
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
has only substance units: false
is: CHEBI:36781
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_efb7cab4_60b6_4630_aab8_b470a076550c
constant: false
boundary condition: true
name: UEVLD
initial amount: NaN
is encoded by: hsa:55293
is: SBO:0000252
is: Q8IX04
type: Species
initial concentration: NaN
has only substance units: false

metaR SPHK21c
is: SBO:0000176
reversible: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.91
modifier: MODEL1310110021#
name: sphingosine kinase 2
kinetic law: MODEL1310110021#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_59251829_490a_4531_b331_4a1a317f6c3a
initial concentration: NaN
is: P23109
initial amount: NaN
has only substance units: false
name: AMPD1
boundary condition: true
is encoded by: hsa:270
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_bdeeb023_a455_465e_9b0f_f207babdef37
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
name: _AW299740_1_m
is encoded by: hsa:AW299740
is: SBO:0000252
boundary condition: true

metaM leugly e
initial amount: NaN
is: http://identifiers.org/pubchem.compound/97364
has only substance units: false
boundary condition: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
name: Leucylglycine
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR r1400
is: SBO:0000185
name: Active transport
product: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reactant: MODEL1310110021#
fast: false
reversible: false
kinetic law: MODEL1310110021#
type: Reaction

metaR r0517
reversible: true
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.17.4.1
is: SBO:0000176
type: Reaction
fast: false

metaR RE1845X
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110021#
name: RE1845
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary

metaM strdnccoa m
name: stearidonyl coenzyme A
boundary condition: false
is: C16163
is: HMDB06519
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
constant: false
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205473

metaR r1493
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
product: MODEL1310110021#
reversible: false
is: SBO:0000185
reactant: MODEL1310110021#
name: Utilized transport
fast: false
kinetic law: MODEL1310110021#
type: Reaction

metaR GGH 7DHFl
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7DHF), lysosomal
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_d800e94b_3b18_48b5_beb0_fa0687a5abfa
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:115019
type: Species
has only substance units: false
constant: false
is: Q7LBE3
name: SLC26A9

metaM cyan m
name: hydrogen cyanide
initial amount: NaN
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: CHEBI:18407
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_302d4f2c_9f05_48cd_b52e_c3a2d26cb25d
initial concentration: NaN
is encoded by: hsa:7296
is: SBO:0000252
boundary condition: true
name: TXNRD1
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaM q10h2 c
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
initial amount: NaN
is: HMDB13111
name: Ubiquinol-10
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

metaM 4hdebrisoquine c
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06468
notes: FORMULA: C10H14N3O CHARGE: 1 INCHI: InChI=1/C10H13N3O/c11-10(12)13-5-7-3-1-2-4-8(7)9(14)6-13/h1-4,9,14H,5-6H2,(H3,11,12)
name: 4 hydroxy debrisoquine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_6483e3bb_f477_452a_a5ec_d95209397995
name: HIBADH
initial concentration: NaN
is: P31937
has only substance units: false
is encoded by: hsa:11112
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaR r1259
type: Reaction
fast: false
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
is: SBO:0000176
product: MODEL1310110021#

metaR GARFT
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
fast: false
product: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
reversible: true
modifier: MODEL1310110021#
name: phosphoribosylglycinamide formyltransferase
is described by: ECO:0000269

metaR r1401
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.35
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.51
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.1.3
modifier: MODEL1310110021#
name: Facilitated diffusion
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/2.7.10.1
reversible: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110021#

metaM HC00822 e
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
is: SBO:0000247
constant: false
is: CHEBI:28681
type: Species
initial concentration: 1.0
name: Chitobiose

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR ASCBt4
fast: false
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
name: L-ascorbate transport via proton symport
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_9544a9a9_726d_4da3_9fe8_79dcfd86037f
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:1577
name: CYP3A5
constant: false
is: Q7Z3N0
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_35d461d5_9641_410c_b81c_d0aa49df23f9
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4706
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: O14561
name: NDUFAB1

metaR r1492
reversible: false
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110021#
fast: false
name: Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR DHAAt1r
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: dehydroascorbate transport (uniport)

metaR SUCCtp
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
name: succinate transporter, peroxisome
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110021#
is: SBO:0000185

metaM coa g
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: coenzyme A(4-)
type: Species
initial amount: NaN
is: HMDB01423
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287

http://identifiers.org/biomodels.db/MODEL1310110021#_dcdd9e1f_a136_4578_993f_283c97e89882
initial amount: NaN
is: P51606
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: RENBP
is encoded by: hsa:5973

metaR 4HDEBRISOQUINEte
is described by: ECO:0000000
is: SBO:0000185
name: xenobiotic transport
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
type: Reaction
reversible: true

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_8fccb2ba_abc6_4957_9aba_68de5b4f4dc8
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_b6dd98c5_2949_494d_ac01_8933b6c3a2b1
is encoded by: hsa:222
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P48448
name: ALDH3B2

metaM HC02213 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
has only substance units: false
is: CHEBI:28031
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin-e3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c5f0a0c8_23dd_4f95_9061_66a63cc2c597
boundary condition: true
is: Q96RN1
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: SLC26A8
is encoded by: hsa:116369
has only substance units: false
is: SBO:0000252

metaR FADDPle
is: SBO:0000176
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000134
name: FAD diphosphatase
fast: false
reactant: MODEL1310110021#

metaR ACOAD10m
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is described by: ECO:0000269
type: Reaction
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110021#

metaM 2mop c
has only substance units: false
name: 2-methyl-3-oxopropanoate
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57700
is: SBO:0000247
is: HMDB01172
initial amount: NaN
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349

http://identifiers.org/biomodels.db/MODEL1310110021#_f493c486_406d_49a1_a85e_dc6397aea2a7
constant: false
initial amount: NaN
is: O60331
name: PIP5K1C
boundary condition: true
is encoded by: hsa:23396
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r2497
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
fast: false
product: MODEL1310110021#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:

metaM aflatoxin e
is: HMDB06552
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C17H12O6 CHARGE: 0 INCHI: InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
is: CHEBI:2504
initial concentration: 1.0
initial amount: NaN
type: Species
name: aflatoxin B1
constant: false

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_fc698de4_f767_4650_8b73_1cb8cde6b07b
name: SLC38A4
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:55089
type: Species
constant: false
is: Q969I6

metaR LGNCt
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110021#
reversible: true

metaM coa n
type: Species
is: SBO:0000247
is: HMDB01423
boundary condition: false
is: CHEBI:57287
initial amount: NaN
constant: false
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
has only substance units: false

metaR PSSA1 hs
name: Phosphatidylserine synthase homo sapiens
product: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.29
reversible: true

metaR r0733
is described by: ECO:0000000
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.1.12

metaM xol7ah2al c
has only substance units: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:27428
initial concentration: 1.0
constant: false
is: HMDB06894

metaR TRPt
is described by: ECO:0000269
reactant: MODEL1310110021#
fast: false
type: Reaction
product: MODEL1310110021#
name: L-tryptophan transport
reversible: true
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185

metaM mev R x
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: SBO:0000247
is: CHEBI:36464
has only substance units: false
initial amount: NaN
type: Species
name: (R)-mevalonate
is: HMDB00227

metaR RE2973C
kinetic law: MODEL1310110021#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
reactant: MODEL1310110021#
fast: false
name: RE2973
product: MODEL1310110021#

metaR r1823
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
product: MODEL1310110021#
reversible: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#

metaR DHCR243r
reactant: MODEL1310110021#
reversible: false
is: SBO:0000176
is described by: ECO:0000134
product: MODEL1310110021#
name: 24-dehydrocholesterol reductase [Precursor]
type: Reaction
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
fast: false
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.1.72
kinetic law: MODEL1310110021#

metaR NDPK2n
reversible: true
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110021#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear

http://identifiers.org/biomodels.db/MODEL1310110021#_f6ddbbf2_3d27_4ca7_bc78_bedd666c1f27
name: FDFT1
initial concentration: NaN
type: Species
is encoded by: hsa:2222
boundary condition: true
is: P37268
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaR RE1709C
reversible: true
fast: false
name: RE1709
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
is described by: ECO:0000000

metaR R group phosphotase 1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
name: R group phosphotase 1
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000

metaM tmndnccoa m
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0
boundary condition: false
is: HMDB06514
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: timnodonyl coenzyme A

metaM apoC c
name: Apocarboxlase (no lys residue)
type: Species
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB11111
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
is: CHEBI:33190

metaR LPS3
is described by: ECO:0000000
modifier: MODEL1310110021#
name: lipase
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
type: Reaction
fast: false
reactant: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.23
product: MODEL1310110021#
is: SBO:0000176

metaM coa m
boundary condition: false
is: CHEBI:57287
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
type: Species
is: C00010
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01423

http://identifiers.org/biomodels.db/MODEL1310110021#_4026411b_67a0_465b_8801_7b6e0ebd54fe
type: Species
is: Q9H015
is encoded by: hsa:6583
constant: false
name: SLC22A4
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR C14STRr
name: C-14 sterol reductase
product: MODEL1310110021#
is described by: ECO:0000134
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.1.70
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
fast: false
reversible: false
type: Reaction

metaM oxa e
is: HMDB02329
initial concentration: 1.0
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
name: oxalate(2-)
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:30623
initial amount: NaN

metaR AIRCr
kinetic law: MODEL1310110021#
type: Reaction
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110021#
name: phosphoribosylaminoimidazole carboxylase
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110021#
reversible: true
is described by: ECO:0000269
is: SBO:0000176

metaR FAOXC14C12x
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaM ptth m
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16753
name: pantetheine
is: HMDB03426

http://identifiers.org/biomodels.db/MODEL1310110021#_08f22b7f_b0ac_4d52_9e4c_f3b4c95dea8d
type: Species
has only substance units: false
has part: P31350
constant: false
has part: P23921
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6240
is: SBO:0000297
initial amount: NaN
name: RRM1:RRM2
is encoded by: hsa:6241

metaR FAOXC10C8m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

metaR r0584
product: MODEL1310110021#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaR r2525
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#
fast: false
reversible: true
product: MODEL1310110021#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

http://identifiers.org/biomodels.db/MODEL1310110021#_0fdfa3b0_d3bb_4504_8355_61e248020914
initial concentration: NaN
has only substance units: false
name: NDUFA2
is: O43678
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:4695
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_a544d778_53e7_4735_b3a8_8226b0312324
is encoded by: hsa:594
is: P21953
type: Species
has only substance units: false
name: BCKDHB
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR r0732
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110021#
is described by: ECO:0000000
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: false
fast: false
product: MODEL1310110021#
is: SBO:0000176

metaR r1824
product: MODEL1310110021#
reversible: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM cys L c
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:17561
type: Species
has only substance units: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: HMDB00574
name: L-cysteine
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_85bf350b_7c7c_4405_b4cf_c39e85557c91
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: _AL050025_1_c
constant: false
boundary condition: true
is encoded by: hsa:AL050025

metaR PEAMNO
name: Phenethylamine oxidase
type: Reaction
is: SBO:0000176
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
is version of: http://identifiers.org/ec-code/1.4.3.4
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.21
reversible: false
reactant: MODEL1310110021#

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaM g3p c
boundary condition: false
is: HMDB01112
is: CHEBI:58027
is: http://identifiers.org/pubchem.compound/3930
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00661
constant: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
type: Species
name: Glyceraldehyde 3-phosphate
initial concentration: 1.0

metaM HC02213 e
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:28031
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_56ebcddf_a2fc_441a_bd30_47c11af64821
constant: false
boundary condition: true
name: UCK2
type: Species
is: SBO:0000252
is encoded by: hsa:7371
initial concentration: NaN
has only substance units: false
is: Q9BZX2
initial amount: NaN

metaR SR5ARr
reactant: MODEL1310110021#
type: Reaction
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.5
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is: SBO:0000176
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
is described by: ECO:0000134
kinetic law: MODEL1310110021#

metaR TKT2
type: Reaction
reactant: MODEL1310110021#
name: transketolase
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is version of: http://identifiers.org/ec-code/2.2.1.1
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_14b45bb9_6c8c_490d_8b8c_b5c0597dcc60
boundary condition: true
is encoded by: hsa:8140
is: SBO:0000252
initial amount: NaN
name: SLC7A5
is: Q8IV97
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaR GTHO
is: SBO:0000176
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000254
name: glutathione oxidoreductase
is version of: http://identifiers.org/ec-code/1.8.1.7
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
type: Reaction
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_a9237402_0364_4376_857d_1970136e065a
constant: false
initial concentration: NaN
is: P00352
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ALDH1A1
is encoded by: hsa:216
initial amount: NaN
type: Species

metaR r2526
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
type: Reaction

metaM pmtcoa c
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01338
initial concentration: 1.0
is: CHEBI:3454
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154

metaR ACCOAC
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_573c7d74_e0e7_4c23_8522_7068b0cc6fb7
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: O75874
is encoded by: hsa:3417
initial amount: NaN
has only substance units: false
name: IDH1

metaM clpn hs c
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
is: CHEBI:28494
name: cardiolipin
initial concentration: 1.0

metaM didp c
name: dIDP
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
initial concentration: 1.0
is: HMDB03536
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:28823

metaR FAOXC161802m
reactant: MODEL1310110021#
reversible: false
name: Beta oxidation fatty acid
is described by: ECO:0000269
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaR r1978
reversible: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#
fast: false

metaR r0731
reversible: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction

metaR r0587
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_50b5635c_e315_45dd_aad1_eac586383d5d
initial concentration: NaN
constant: false
is: Q8N0X4
is: SBO:0000252
name: CLYBL
is encoded by: hsa:171425
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_9f932e4d_a439_4833_9426_2af07242b486
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AA526438
is: SBO:0000252
initial amount: NaN
name: _AA526438_1_c
constant: false
type: Species

metaR TKT1
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110021#
name: transketolase
type: Reaction
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.1
reactant: MODEL1310110021#

metaM dgchol c
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00637
boundary condition: false
name: glycochenodeoxycholate
is: CHEBI:36252
initial amount: NaN
is: SBO:0000247

metaR PPCOAOm
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is: SBO:0000176

metaR GTHP
is version of: http://identifiers.org/ec-code/1.11.1.9
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
product: MODEL1310110021#
reactant: MODEL1310110021#
name: glutathione peroxidase
type: Reaction
reversible: true
modifier: MODEL1310110021#
fast: false
is: SBO:0000176
is described by: ECO:0000134

metaM leugly c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/97364
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Leucylglycine
notes: FORMULA: C8H16N2O3 CHARGE: 0
type: Species

metaM oxa c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
constant: false
name: oxalate(2-)
has only substance units: false
boundary condition: false
is: CHEBI:30623

http://identifiers.org/biomodels.db/MODEL1310110021#_48020e92_c1d7_48fd_b159_57a7f22c1e47
initial amount: NaN
is encoded by: hsa:84532
type: Species
is: Q9NUB1
boundary condition: true
constant: false
is: SBO:0000252
name: ACSS1
initial concentration: NaN
has only substance units: false

metaR H2Otly
fast: false
reversible: true
is: SBO:0000185
name: H2O transport, lysosomal
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110021#_c9ff7adf_7715_4611_bec9_02c054b1b008
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110021#_61bf2646_0850_4359_bf77_1d364dd8a938
is: SBO:0000252
boundary condition: true
is: Q9HBF5
constant: false
initial amount: NaN
is encoded by: hsa:400410
has only substance units: false
initial concentration: NaN
type: Species
name: ST20

metaM o2 x
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
type: Species
is: SBO:0000247
name: O2
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00007

metaR r0660
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
reversible: true
kinetic law: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction

metaR ABUTt2r
kinetic law: MODEL1310110021#
name: 4-aminobutyrate reversible transport in via proton symport
reversible: true
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
modifier: MODEL1310110021#
is described by: ECO:0000304

metaR r0730
product: MODEL1310110021#
fast: false
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#

metaM psyl e
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
constant: false
is: http://identifiers.org/pubchem.compound/94244
name: psyllium
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM cys L e
constant: false
is: CHEBI:17561
type: Species
boundary condition: false
is: HMDB00574
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
name: L-cysteine
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM trdox c
constant: false
has only substance units: false
is: CHEBI:18191
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: Oxidized thioredoxin
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false

metaM 2dr5p c
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
initial amount: NaN
type: Species
is: CHEBI:57651
is: HMDB01031
has only substance units: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247

metaR r2380
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR r1979
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
product: MODEL1310110021#

metaM 4hdebrisoquine e
name: 4 hydroxy debrisoquine
type: Species
notes: FORMULA: C10H14N3O CHARGE: 1 INCHI: InChI=1/C10H13N3O/c11-10(12)13-5-7-3-1-2-4-8(7)9(14)6-13/h1-4,9,14H,5-6H2,(H3,11,12)
boundary condition: false
constant: false
is: HMDB06468
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR r1826
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110021#
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_6142505b_a849_493d_8be4_75c4abad1eb4
constant: false
is encoded by: hsa:218
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ALDH3A1
has only substance units: false
type: Species
is: P30838

metaM pi c
is: HMDB00973
boundary condition: false
constant: false
is: C00009
is: SBO:0000247
is: CHEBI:43474
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2
initial concentration: 1.0
name: hydrogenphosphate
has only substance units: false
type: Species

metaR CO2t
reactant: MODEL1310110021#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
name: CO2 transporter via diffusion
fast: false
kinetic law: MODEL1310110021#

metaM akg m
initial concentration: 1.0
boundary condition: false
name: 2-Oxoglutarate
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:16810
is: C00026
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: HMDB00208
type: Species

metaM HC00822 l
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
name: Chitobiose
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:28681
type: Species
initial amount: NaN

metaM lnlncg l
constant: false
name: gamma-linolenate
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: HMDB03073
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:32391
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_63a1930b_aabc_4c4e_bef0_60d729832553
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q05C14
initial concentration: NaN
is encoded by: hsa:2352
name: FOLR3

metaR AMETr
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
is: SBO:0000185
type: Reaction
name: S-Adenosyl-L-methionine intracellular diffusion
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
fast: false
reactant: MODEL1310110021#

metaR ATP1ter
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
name: ADP/ATP transporter, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110021#
is: SBO:0000185

metaR PI345P3P
fast: false
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.3.67
is: SBO:0000176
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
reversible: false

metaR DSAT
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110021#
reversible: false
type: Reaction
name: dihydrosphingosine N-acyltransferase
fast: false

metaM malttr e
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01262
is: C01835
has only substance units: false
is: CHEBI:27931
name: maltotriose
initial amount: NaN
constant: false

metaR RE3245C
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
name: RE3245
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_565a5c3e_8ea9_4d48_853b_39c0a3acf70e
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55808
is: Q9NSC7
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: ST6GALNAC1

metaR RE1691M
is version of: http://identifiers.org/ec-code/2.8.1.1
kinetic law: MODEL1310110021#
name: RE1691
product: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e6255e94_9d4f_4866_b250_b596e2ae7c94
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5290
is: SBO:0000252
constant: false
name: PIK3CA
is: P42336
type: Species
initial amount: NaN
boundary condition: true

metaR OCTAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
fast: false
name: Octanoate transport via diffusion
is described by: ECO:0000000

metaR ACACT10m
kinetic law: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR DNDPt39m
reactant: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
is: SBO:0000185
reversible: false
name: dUTP transport via dGDP antiport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110021#_42954022_a2fa_4c58_8bae_5073e050ee23
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:6476
has only substance units: false
initial amount: NaN
name: SI
is: P14410
boundary condition: true
is: SBO:0000252

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR G3PD1
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
reversible: true
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.8
fast: false
is described by: ECO:0000269
name: glycerol-3-phosphate dehydrogenase (NAD)
product: MODEL1310110021#

metaM cyan e
is: CHEBI:18407
has only substance units: false
name: hydrogen cyanide
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: HMDB02084
constant: false

metaM thr L c
is: HMDB00167
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
constant: false
name: L-threonine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247

metaM mi1345p c
initial concentration: 1.0
type: Species
is: CHEBI:57895
is: HMDB01059
has only substance units: false
boundary condition: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
constant: false
is: SBO:0000247
initial amount: NaN

metaR 10FTHFtm
reversible: true
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
is: SBO:0000185

metaR r2382
is described by: ECO:0000000
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_5fc4fb1d_5e46_46d8_9d0c_3cc7a630919e
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: _AI971036_1_m
is encoded by: hsa:AI971036
initial concentration: NaN
type: Species

metaR URIt
name: uridine facilated transport in cytosol
reactant: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
is: SBO:0000185

metaM apoC Lys m
name: Apocarboxylase (Lys residue)
constant: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: CHEBI:32551
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00182
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_67bb77e3_2fb2_4bbe_b0cf_9aaf86e88999
has only substance units: false
initial concentration: NaN
is encoded by: hsa:377841
name: ENTPD8
boundary condition: true
constant: false
initial amount: NaN
is: Q5MY95
is: SBO:0000252
type: Species

metaR r0580
is described by: ECO:0000000
kinetic law: MODEL1310110021#
is: SBO:0000176
reversible: true
modifier: MODEL1310110021#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.7
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
type: Reaction

metaR UDPGLCter
is: SBO:0000185
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
type: Reaction
reversible: true
name: UDP-Glc endoplasmic reticulum transport via CMP antiport

http://identifiers.org/biomodels.db/MODEL1310110021#_c54d6c6c_c39b_4306_9a35_c35789f90d50
is: P28329
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:1103
name: CHAT
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR TMDPK
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.2
product: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_5926df99_1878_4f77_8fd2_e2d6cc44ce1a
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _NM_013421_1_e
constant: false
is encoded by: hsa:NM 013421
type: Species
initial concentration: NaN

metaR DM ethamp r
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_02b843d9_a547_4368_9c42_6e29df075a73
has only substance units: false
is: P22303
name: ACHE
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:43
boundary condition: true

metaR FAOXC1811603m
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#
name: Beta oxidation fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110021#

metaM cholcoa x
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:57373
is: SBO:0000247
initial concentration: 1.0
is: HMDB01374
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
type: Species

metaR PHCDm
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
product: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
fast: false
modifier: MODEL1310110021#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase

metaR r2385
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reversible: false
is: SBO:0000185

metaR r1821
is: SBO:0000185
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#

metaM pyr c
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:15361
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3324
notes: FORMULA: C3H3O3 CHARGE: -1
name: pyruvate
initial concentration: 1.0
is: SBO:0000247
is: HMDB00243
is: C00022

metaR r1364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110021#
name: Vesicular transport
kinetic law: MODEL1310110021#

metaR r0735
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM cs c deg2 l
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00127
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2
boundary condition: false
is: CHEBI:15748

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_28fb3aa1_8067_49b2_ad7d_de57e34fad22
has only substance units: false
is encoded by: hsa:53354
constant: false
name: PANK1
is: Q8TE04
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaM dtmp m
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01227
is: C00364
initial amount: NaN
is: CHEBI:26999
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
name: dTMP
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_1514ce91_8718_4727_a3ca_52fdd4f54f2b
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56301
constant: false
is: Q9NS82
name: SLC7A10
type: Species
initial amount: NaN
initial concentration: NaN

metaR RE3050R
is: SBO:0000176
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
fast: false
type: Reaction
name: RE3050

metaM dhor S c
constant: false
initial concentration: 1.0
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
boundary condition: false
is: HMDB03349
is: SBO:0000247
type: Species
name: (S)-dihydroorotate
is: CHEBI:30864
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_aef934d7_7d7d_4b2d_b95b_bab4265e0bd7
constant: false
type: Species
name: ABP1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:26
is: P19801
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_851dd056_2b7a_4b5c_a65c_18eecfdd3165
is encoded by: hsa:10861
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SLC26A1
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_dec9d4fc_5b28_498e_8b6e_caf6819dba1c
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: O95139
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:4712
name: NDUFB6

http://identifiers.org/biomodels.db/MODEL1310110021#_7df67b26_a58f_4a7d_8824_08cc705d8383
initial concentration: NaN
name: SLC16A8
is: O95907
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:23539
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_0aea96c8_8193_4734_a2a9_c357c80ceaf1
has only substance units: false
is: Q01581
is encoded by: hsa:3157
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: HMGCS1
constant: false
initial concentration: NaN

metaM tdcoa c
is: CHEBI:57385
initial concentration: 1.0
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521
constant: false
is: SBO:0000247

metaR BILIRUBtr
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e81cf38e_b9bf_4ca6_946c_56b285143d08
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:215
name: ABCD1
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: P33897
boundary condition: true

metaM arab L e
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0
boundary condition: false
name: L-arabinose
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00646
has only substance units: false
is: CHEBI:30849
type: Species

metaR r2384
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM glyc3p c
is: HMDB00126
is: C00093
boundary condition: false
name: Glycerol 3-phosphate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: SBO:0000247
is: CHEBI:57597
initial amount: NaN
type: Species
constant: false

metaR DMHPTCRNCPT2
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
product: MODEL1310110021#
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110021#
name: 2,6 dimethylheptanoly CoA carnitine transferase
fast: false

metaM CE2705 n
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
name: quinonoid dihydrobiopterin
is: HMDB02281
has only substance units: false
constant: false
is: CHEBI:15374
type: Species

metaR r0734
is: SBO:0000176
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110021#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false

metaR r1365
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110021#
reversible: false
is: SBO:0000185
reactant: MODEL1310110021#
name: Vesicular transport

metaM 34hpp c
initial amount: NaN
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247
initial concentration: 1.0
is: HMDB00707
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
boundary condition: false
is: CHEBI:36242
has only substance units: false
constant: false

metaM tcynt m
is: CHEBI:18022
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01453
name: thiocyanate
has only substance units: false
boundary condition: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false

metaR VALLAT1tc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR ADSS
is: SBO:0000176
name: adenylosuccinate synthase
kinetic law: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.4
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
modifier: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000134
product: MODEL1310110021#
fast: false

metaR THYOXt2
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
is: SBO:0000185
product: MODEL1310110021#
name: T4 transport via facilitated diffusion
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_267b44a7_d80e_4476_aea7_36d8330dd527
initial concentration: NaN
name: GALT
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
is: E7ET32
is encoded by: hsa:2592

metaM co2 r
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
constant: false
is: CHEBI:16526
name: CO2
initial amount: NaN
is: HMDB01967
is: C00011

metaM methf m
has only substance units: false
is: CHEBI:57455
boundary condition: false
constant: false
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
name: (6R)-5,10-methenyltetrahydrofolate
is: SBO:0000247
is: HMDB01354
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_3727bc6b_5bed_42cd_86cb_636f7096cf70
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:122481
initial concentration: NaN
constant: false
name: AK7
is: Q96M32
is: SBO:0000252
boundary condition: true

metaR DNDPt9m
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reversible: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110021#
fast: false
name: dADP transport via dTDP antiport
reactant: MODEL1310110021#

metaR PTPATe
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
fast: false
reversible: true
name: PTPATe
is described by: ECO:0000134

metaM cyan c
boundary condition: false
is: CHEBI:18407
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
is: HMDB02084
name: hydrogen cyanide

http://identifiers.org/biomodels.db/MODEL1310110021#_966767ed_9c9c_41cf_9f14_29877738c877
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1716
name: DGUOK
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM dhcholestancoa x
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:15494
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
initial amount: NaN
is: HMDB02159
is: SBO:0000247

metaR FUMtm
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
modifier: MODEL1310110021#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110021#
name: fumarate transport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110021#_2735d220_a235_45dd_ab41_73e032d01e0b
constant: false
is: SBO:0000252
is: O00476
initial amount: NaN
boundary condition: true
name: SLC17A3
has only substance units: false
is encoded by: hsa:10786
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_3549bb43_09b9_47e6_b00e_ebc893136388
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PIPOX
boundary condition: true
is encoded by: hsa:51268
is: Q9P0Z9
constant: false

metaM pi g
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:43474
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_b5ffd7d6_9ec2_456c_acb1_92c0a6efa275
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P82251
name: SLC7A9
is encoded by: hsa:11136
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d5ab78cb_a626_4245_9160_84c80dd52121
name: ADH1A
boundary condition: true
is: P07327
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:124
initial concentration: NaN
is: SBO:0000252
type: Species

metaM didp n
boundary condition: false
is: SBO:0000247
is: HMDB03536
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
is: CHEBI:28823
initial concentration: 1.0
name: dIDP

metaR r0512
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: true
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
reactant: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_d066bb52_01b3_4ad2_8f86_d57b85e04266
boundary condition: true
type: Species
initial concentration: NaN
is: P04035
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3156
name: HMGCR

metaR r2387
kinetic law: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM hyptaur c
constant: false
has only substance units: false
type: Species
is: HMDB00965
name: Hypotaurine
is: SBO:0000247
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
initial amount: NaN
boundary condition: false
is: CHEBI:16668
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_a355b6ef_1de2_4bf0_b495_fbb75150290b
name: PCBD1
initial concentration: NaN
is encoded by: hsa:5092
constant: false
is: P61457
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false

metaM ach c
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
has only substance units: false
constant: false
is: CHEBI:15355
type: Species
initial amount: NaN
is: HMDB00895
boundary condition: false
name: acetylcholine
initial concentration: 1.0
is: SBO:0000247

metaR RE0383C
reversible: true
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
name: RE0383
type: Reaction
fast: false

metaR UDPDOLPT L
product: MODEL1310110021#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.117
modifier: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000176
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)

metaR CO2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
name: CO2 peroxisomal transport

metaR TCYNTt
fast: false
product: MODEL1310110021#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Thiocyanate transport via diffusion (cytosol to extracellular)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reactant: MODEL1310110021#

metaR NTD7
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (AMP)
is: SBO:0000176
fast: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction

metaR EHGLATm
type: Reaction
reactant: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
is described by: ECO:0000212
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial

metaM cdp c
boundary condition: false
has only substance units: false
is: CHEBI:58069
is: C00112
name: CDP
is: HMDB01546
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaM 34hpp e
initial amount: NaN
constant: false
is: CHEBI:36242
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: HMDB00707
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_d5a6d6ed_4b5d_4321_8e8a_20b7d0d5dc88
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1718
name: DHCR24
has only substance units: false
is: Q15392
type: Species
initial concentration: NaN
constant: false

metaR r2386
is: SBO:0000185
kinetic law: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110021#
is described by: ECO:0000000

metaM arab L c
name: L-arabinose
constant: false
boundary condition: false
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
is: CHEBI:30849
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

metaR PIPLC
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol phospholipase C
fast: false
reversible: false
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR P5CDm
is: SBO:0000176
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_9f8d7f19_1915_4eec_a320_7589bcf6d858
constant: false
is: SBO:0000252
is encoded by: hsa:5330
type: Species
initial concentration: NaN
is: Q59F77
name: PLCB2
has only substance units: false
boundary condition: true
initial amount: NaN

metaR MTHFD2m
product: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
reactant: MODEL1310110021#
reversible: true
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
kinetic law: MODEL1310110021#
is described by: ECO:0000254
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_0c10aa73_390f_4452_87d1_63ffa0ed408a
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:956
is: O75355
initial concentration: NaN
name: ENTPD3
constant: false
is: SBO:0000252
initial amount: NaN

metaR DCK1n
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
product: MODEL1310110021#
name: Deoxycytidine kinase, nuclear (ATP)
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_f475709c_7c03_469f_8d0e_1e505b368da9
name: SYNJ2
type: Species
is: O15056
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8871
has only substance units: false

metaM 2oxoadp m
has only substance units: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: CHEBI:57499
type: Species
is: HMDB00225
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
name: 2-oxoadipate(2-)
boundary condition: false

metaR PROt4 2 r
name: Proline transport (sodium symport) (2:1)
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
modifier: MODEL1310110021#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000006

metaR NADtx
kinetic law: MODEL1310110021#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110021#
type: Reaction
name: transport of NAD into peroxisome
product: MODEL1310110021#

metaR r1367
fast: false
reversible: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Vesicular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction

metaM lnlncg r
is: CHEBI:32391
has only substance units: false
constant: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial amount: NaN
name: gamma-linolenate
is: SBO:0000247
initial concentration: 1.0
is: HMDB03073
boundary condition: false

metaR C3STDH1Pr
is version of: http://identifiers.org/ec-code/1.1.1.170
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
type: Reaction
is described by: ECO:0000134
name: C-3 sterol dehydrogenase (4-methylzymosterol)
fast: false
reactant: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1a89dfc9_6864_441e_a9a2_ae092d973e73
initial concentration: NaN
name: HSD17B10
type: Species
is encoded by: hsa:3028
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q99714
constant: false
is: SBO:0000252

metaR SIAT9g
is version of: http://identifiers.org/ec-code/2.4.99.9
kinetic law: MODEL1310110021#
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
modifier: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_87b67c01_f7b5_4ee1_97ff_6a6ec92be76b
name: _J03866_1_m
type: Species
initial amount: NaN
is encoded by: hsa:J03866
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r0514
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: false
product: MODEL1310110021#
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
modifier: MODEL1310110021#

metaR r0434
reactant: MODEL1310110021#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
reversible: true
modifier: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR RE1516M
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110021#
is described by: ECO:0000000
name: RE1516
is: SBO:0000176
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
reversible: true

metaR PRISTANALtx
fast: false
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#
is described by: ECO:0000000
name: pristanal peroxisomal transport
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ

metaM spmd e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01257
is: C00315
type: Species
is: SBO:0000247
is: CHEBI:57834
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
name: Spermidine
constant: false

metaR HMGCOARc
reactant: MODEL1310110021#
reversible: false
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.34
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
type: Reaction
is described by: ECO:0000134
is: SBO:0000176

metaM co2 m
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526
is: SBO:0000247
has only substance units: false
is: HMDB01967
name: CO2
type: Species
initial amount: NaN
initial concentration: 1.0
is: C00011
boundary condition: false
constant: false

metaR r2022
kinetic law: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
type: Reaction
reversible: false
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reactant: MODEL1310110021#

metaR CYTDt
name: cytidine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110021#
product: MODEL1310110021#
fast: false
reversible: true
modifier: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000269

metaR r0739
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
product: MODEL1310110021#
is: SBO:0000176
type: Reaction
reversible: true
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1

metaR DHCHOLESTANATEtm
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
kinetic law: MODEL1310110021#
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000

metaM pi e
name: hydrogenphosphate
has only substance units: false
is: HMDB00973
constant: false
is: CHEBI:43474
is: C00009
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial concentration: 1.0

metaR LNLCCPT1
reactant: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
reversible: false
fast: false
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110021#_780e58ed_a271_40ca_90d5_0d14cdc1c94d
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:2182
boundary condition: true
name: ACSL4
is: Q5JWV8
initial concentration: NaN
is: SBO:0000252

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM xol7ah2al m
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB06894
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: SBO:0000247
is: CHEBI:27428

metaR FAOXC122C101m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_aca42e11_d4ac_4405_a8e7_cbb351b1033e
name: CPT1B
is: Q53FV7
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:1375
initial concentration: NaN
type: Species

metaR r1368
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110021#
name: Vesicular transport
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
fast: false

metaR It
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
product: MODEL1310110021#
reversible: true
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000269
name: Iodide uniport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#

metaR r2389
reversible: false
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110021#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110021#

metaR RE1709N
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
name: RE1709
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_9e6b52f0_6ab8_415d_b614_458e84f4cbdf
has only substance units: false
is: Q53HM1
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54963
name: UCKL1

metaR r0879
reversible: false
reactant: MODEL1310110021#
type: Reaction
fast: false
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
kinetic law: MODEL1310110021#

metaM HC01610 e
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
name: CoproporphyrinogenI
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:28607
constant: false
initial amount: NaN

metaM cmp n
name: CMP(2-)
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00095
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377

metaR r2388
modifier: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR FAOXC10C8x
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM cdp e
is: HMDB01546
is: CHEBI:58069
name: CDP(3-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000247

metaM q10h2 e
type: Species
constant: false
boundary condition: false
has only substance units: false
name: Ubiquinol-10
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial amount: NaN
is: HMDB13111

metaM 4mop m
boundary condition: false
initial amount: NaN
is: HMDB00695
is: CHEBI:17865
name: 4-methyl-2-oxopentanoate
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false

metaM thr L e
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
boundary condition: false
is: CHEBI:16857
name: L-threonine
constant: false
is: HMDB00167

metaR ETFQO
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.5.5.1
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
fast: false
product: MODEL1310110021#

metaR EX adprbp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose 2'-phosphate exchange
type: Reaction

metaR LNLCCPT2
product: MODEL1310110021#
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110021#
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_e55dfc6f_c199_448e_bb7b_2e0d66e39b79
initial amount: NaN
name: ALDH3A2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:224
boundary condition: true
has only substance units: false
is: P51648
type: Species
constant: false

metaR RE3627M
modifier: MODEL1310110021#
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000176
name: RE3627

http://identifiers.org/biomodels.db/MODEL1310110021#_fc65fded_e784_4b84_ba40_fd8f46d5c094
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI971036
name: _AI971036_1_c
constant: false
has only substance units: false

metaR GLYOX
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
modifier: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.6
reversible: false
name: hydroxyacylglutathione hydrolase
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false

metaM fprica c
is: SBO:0000247
is: HMDB01439
boundary condition: false
is: C04734
is: CHEBI:58467
constant: false
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
type: Species
initial concentration: 1.0
initial amount: NaN
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false

metaR NCKt
type: Reaction
modifier: MODEL1310110021#
reversible: true
is: SBO:0000185
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: Na+/Ca2+-K+ exchange

metaR CO2tm
product: MODEL1310110021#
name: CO2 transport (diffusion), mitochondrial
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is described by: ECO:0000000

metaR 5OXPROt
product: MODEL1310110021#
name: Transport of 5-oxoprolinate
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
reactant: MODEL1310110021#
is: SBO:0000185
type: Reaction

metaM coa c
is: C00010
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01423
is: CHEBI:3312
boundary condition: false
type: Species
name: Coenzyme A
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_29732212_bff3_4a05_b46a_2edd50d792e9
constant: false
is: SBO:0000252
is: P30837
has only substance units: false
is encoded by: hsa:219
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ALDH1B1

metaM xol7aone c
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB01993
is: CHEBI:17899
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455

metaM HC01407 m
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: (S)-Hydroxyhexanoyl-CoA
is: CHEBI:28276
constant: false

metaR r2378
product: MODEL1310110021#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110021#

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is described by: ECO:0000269
name: Sulfate transport (lysosome)
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110021#
is: SBO:0000185

metaR r2019
is described by: ECO:0000000
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#

metaR C4STMO2r
is described by: ECO:0000000
product: MODEL1310110021#
name: C-4 methyl sterol oxidase
reversible: false
kinetic law: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.72
is version of: http://identifiers.org/ec-code/1.1.1.170
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
type: Reaction
modifier: MODEL1310110021#

metaM CE0713 m
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
name: 3-oxolinoleoyl-CoA
is: SBO:0000247
type: Species
is: HMDB02329
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:30623

metaR B3GALT3g
is: SBO:0000176
product: MODEL1310110021#
fast: false
name: Beta-1,3-galactosyltransferase 3
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.79
reversible: false
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM prostge2 c
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:606564
has only substance units: false
name: prostaglandin E2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
boundary condition: false
is: HMDB01220
constant: false
is: SBO:0000247

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaM gthrd m
boundary condition: false
has only substance units: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: glutathionate(1-)
is: CHEBI:57925
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00125

metaR r0941
is: SBO:0000185
reactant: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
fast: false
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
reversible: true

metaR MAL Lte
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of L-malate
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaR r1594
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000

metaM HC01376 m
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:28692
has only substance units: false
is: SBO:0000247
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
name: S-(2-Methylbutanoyl)-dihydrolipoamide
constant: false

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_73810c4a_3036_486b_bd5b_03c0d2b34497
type: Species
is: B3KTV4
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:122622
name: ADSSL1
constant: false
initial concentration: NaN

metaM nadp x
is: CHEBI:58349
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
is: HMDB00217
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

http://identifiers.org/biomodels.db/MODEL1310110021#_316de378_cbba_40ba_8f65_f84c3073334e
is encoded by: hsa:58510
constant: false
initial amount: NaN
has only substance units: false
name: PRODH2
is: Q9UF12
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR KCCt
is: SBO:0000185
type: Reaction
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110021#
name: K+-Cl- cotransport
reactant: MODEL1310110021#
fast: false

metaM tdcoa x
type: Species
is: SBO:0000247
is: CHEBI:57385
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN

metaR RE2972M
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.67
name: RE2972
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
modifier: MODEL1310110021#
type: Reaction

metaR r2379
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR r1512
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Utilized transport
reversible: false
type: Reaction

metaR r0249
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110021#
reversible: true
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
type: Reaction
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
is described by: ECO:0000000
product: MODEL1310110021#
fast: false

metaR PTE3x
notes: GENE_ASSOCIATION: (10965.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10944470 NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110021#
type: Reaction
reversible: false
product: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
kinetic law: MODEL1310110021#
name: peroxisomal acyl-CoA thioesterase
reactant: MODEL1310110021#

metaR r1610
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR r0139
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_fc82bb75_83d4_4cc8_b6e4_78960deb156f
boundary condition: true
type: Species
initial amount: NaN
is: P05091
has only substance units: false
is: SBO:0000252
name: ALDH2
is encoded by: hsa:217
initial concentration: NaN
constant: false

metaR r0940
reversible: true
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
name: Free diffusion
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM thf c
is: HMDB01846
initial concentration: 1.0
constant: false
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate
is: CHEBI:57453
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
is: C00101
type: Species
boundary condition: false

metaM mev R c
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00227
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:36464
name: (R)-mevalonate
boundary condition: false

metaR LEULEULAPc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR r1595
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR GULNDer
fast: false
name: gulonate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reactant: MODEL1310110021#
type: Reaction
reversible: true
kinetic law: MODEL1310110021#

metaM i e
is: HMDB12238
is: SBO:0000247
name: iodide
boundary condition: false
initial concentration: 1.0
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
is: CHEBI:16382
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_0e2decac_bf3e_4b8f_a268_2c528f7ddb18
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:U37519
constant: false
initial concentration: NaN
name: _U37519_1_m
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_4950b4ae_98ff_4b00_b318_98613ba891c8
name: ALDOA
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:226
is: SBO:0000252
constant: false
initial concentration: NaN
is: P04075

metaM ddcacoa x
type: Species
is: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
is: HMDB03571
has only substance units: false
boundary condition: false
is: CHEBI:57375
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR GCC2bim
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reversible: false
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110021#

metaR ASNtm
name: L-asparagine transport, mitochondrial
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV

metaR r1611
product: MODEL1310110021#
reactant: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_b7dc9a3a_f3fb_4650_bc82_16909fd5882f
is encoded by: hsa:131
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: P40394
constant: false
name: ADH7

http://identifiers.org/biomodels.db/MODEL1310110021#_af74599a_05cc_46d1_bbd3_822b13d8e26f
type: Species
is encoded by: hsa:80025
initial concentration: NaN
is: Q6P1K9
constant: false
initial amount: NaN
name: PANK2
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR KAS8
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
type: Reaction
name: b-ketoacyl synthetase (palmitate, n-C16:0)
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reversible: false
is: SBO:0000176

metaM pmtcoa x
is: SBO:0000247
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
type: Species
is: HMDB01338
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57379
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_8a1f1fa7_a12d_4c93_b782_6b36db7ab447
is encoded by: hsa:1384
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: CRAT
constant: false

metaM dtmp c
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:26999
has only substance units: false
type: Species
is: HMDB01227
is: C00364
constant: false
name: dTMP
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364

metaM coa x
name: Coenzyme A
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
is: CHEBI:57287
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00010
has only substance units: false
type: Species

metaM xoldiolone c
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:28477
is: HMDB02197
boundary condition: false
constant: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

metaR r1592
product: MODEL1310110021#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_8deb5937_8c5e_4822_94a3_f337898a1fc4
boundary condition: true
initial concentration: NaN
is encoded by: hsa:60490
is: Q96CD2
has only substance units: false
is: SBO:0000252
name: PPCDC
type: Species
initial amount: NaN
constant: false

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR FOLt2le
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
name: folate transport via anion exchange
reversible: true
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185

metaM pa hs c
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57739
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
type: Species
initial amount: NaN

metaR r0437
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
product: MODEL1310110021#

metaR CRNt
is described by: ECO:0000269
product: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
name: L-carnitine reversible transport
kinetic law: MODEL1310110021#
type: Reaction
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_12dcb111_50a4_4d85_9ed2_ab028333b1f4
is: SBO:0000252
name: AMY1B
is: P04745
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:277
type: Species
constant: false
has only substance units: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM dtmp e
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: HMDB01227
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:26999
boundary condition: false
name: dTMP(2-)
is: SBO:0000247
initial amount: NaN

metaR r1612
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110021#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#

metaR FORtr
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
name: FOR transporter, endoplasmic reticulum
is: SBO:0000185
reactant: MODEL1310110021#

metaR MALTSULtm
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000269
modifier: MODEL1310110021#
name: Malate:thiosulfate antiport, mitochondrial
type: Reaction
reversible: true
kinetic law: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f2495393_1a64_41fa_9ff3_50f5b9d76557
constant: false
initial concentration: NaN
name: NDUFS1
type: Species
is: SBO:0000252
is encoded by: hsa:4719
has only substance units: false
is: P28331
initial amount: NaN
boundary condition: true

metaR r1593
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r0942
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
is: SBO:0000185
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4

metaR FACOAL2251
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110021#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase

metaR OMHPALTD
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM i c
initial amount: NaN
name: iodide
is: HMDB12238
is: SBO:0000247
boundary condition: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:16382
constant: false

metaR ACACT1r
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is: SBO:0000176
fast: false
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.9
is described by: ECO:0000000
kinetic law: MODEL1310110021#
name: acetyl-CoA C-acetyltransferase
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR DUDPtn
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
name: dUDP nuclear transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_0b0bab06_82cf_42a1_bb8d_e3df68e81a15
name: _AI824319_1_r
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI824319
initial amount: NaN

metaR r1598
type: Reaction
reactant: MODEL1310110021#
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#

metaR r1613
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_75f6dfb6_1174_4049_8e7c_25c3dca7df14
is: SBO:0000252
constant: false
name: ABCA1
has only substance units: false
is encoded by: hsa:19
initial amount: NaN
is: O95477
boundary condition: true
initial concentration: NaN
type: Species

metaR NAIt
product: MODEL1310110021#
is described by: ECO:0000269
kinetic law: MODEL1310110021#
type: Reaction
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
reversible: true
name: Na+ / iodide cotransport
modifier: MODEL1310110021#
is: SBO:0000185

metaR r0246
reversible: false
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
reactant: MODEL1310110021#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
modifier: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000000

metaM 2mop m
is: CHEBI:57700
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
has only substance units: false
is: HMDB01172
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 2-methyl-3-oxopropanoate
boundary condition: false
constant: false
type: Species

metaR LNLCt
reversible: true
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
name: Linoleic acid (n-C18:2) transport in via diffusion
type: Reaction
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_f8b9c9bd_7459_4468_8dc8_4828028431a0
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is: Q9HAB8
initial amount: NaN
is encoded by: hsa:79717
has only substance units: false
name: PPCS

metaM andrstrn r
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00031
is: CHEBI:16032
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial concentration: 1.0
boundary condition: false
constant: false
name: androsterone
type: Species

metaR DURItn
reactant: MODEL1310110021#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: deoxyuridine transport in nucleus
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_7ec147a7_91ed_4797_bdc5_2ee02c210528
is encoded by: hsa:7360
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: UGP2
has only substance units: false
is: Q16851

metaM pi n
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
boundary condition: false
name: hydrogenphosphate
type: Species
is: HMDB00973
is: SBO:0000247
is: CHEBI:43474
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_81391a48_36f2_4460_8461_38ab3b3842de
is encoded by: hsa:AI972237
type: Species
constant: false
initial concentration: NaN
name: _AI972237_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_df6f5f1d_a191_4ddf_b663_3f76744e2323
name: ALDH7A1
constant: false
is: E7EPT3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:501
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_ceefa389_ecbd_42e9_8731_d02d772da5ff
has only substance units: false
name: SLC7A8:SLC3A2
boundary condition: true
is: SBO:0000297
type: Species
initial amount: NaN
has part: Q86U05
is encoded by: hsa:23428
initial concentration: NaN
constant: false

metaM 5aop m
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: SBO:0000247
is: C00430
name: 5-Amino-4-oxopentanoate
is: HMDB01149
initial concentration: 1.0
type: Species
is: CHEBI:17549

http://identifiers.org/biomodels.db/MODEL1310110021#_74b1d002_8bbc_4840_a2ad_d0aee2b7c367
initial amount: NaN
name: PLCB1
boundary condition: true
is encoded by: hsa:23236
constant: false
is: Q9NQ66
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM pmtcoa r
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
has only substance units: false
is: HMDB01338
is: C00154
is: CHEBI:3454
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR DGSNtm
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000185
fast: false
name: deoyguanosine transport in mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
reversible: true
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR r0086
modifier: MODEL1310110021#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.3
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
fast: false
reversible: false
reactant: MODEL1310110021#
is: SBO:0000176

metaR DTMPK
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.9
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110021#
name: dTMP kinase
reactant: MODEL1310110021#

metaM btamp m
initial concentration: 1.0
name: Biotinyl-5'-AMP
constant: false
has only substance units: false
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
boundary condition: false
initial amount: NaN
is: CHEBI:3110
is: SBO:0000247
is: HMDB04220

metaR r0021
is described by: ECO:0000000
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton

metaR DGK1
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.8
modifier: MODEL1310110021#
product: MODEL1310110021#
fast: false
is: SBO:0000176
is described by: ECO:0000269
name: deoxyguanylate kinase (dGMP:ATP)

metaR r1599
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reversible: true

metaR r1614
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR DCYTt
type: Reaction
kinetic law: MODEL1310110021#
name: deoxycytidine transport via diffusion
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_21d72322_85ba_420b_8d2d_ca557e80ca37
type: Species
is: P16260
name: SLC25A16
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8034
has only substance units: false
boundary condition: true

metaM fum c
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
boundary condition: false
name: Fumarate
is: C00122
has only substance units: false
is: HMDB00134
is: CHEBI:29806
type: Species
is: SBO:0000247

metaR r0245
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.1.3
modifier: MODEL1310110021#
fast: false
is: SBO:0000176
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reactant: MODEL1310110021#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_34700f00_2b5d_49b5_817a_6e42afb1f3f6
is encoded by: hsa:79143
is: Q96N66
initial amount: NaN
type: Species
name: MBOAT7
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM dmnoncoa m
name: 4,8 dimethylnonanoyl-CoA
has only substance units: false
is: HMDB11604
type: Species
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM dutp c
is: HMDB01191
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
type: Species
is: SBO:0000247
is: C00460
has only substance units: false
boundary condition: false
is: CHEBI:17625
initial amount: NaN
name: dUTP
initial concentration: 1.0

metaM pyr e
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial amount: NaN
constant: false
is: HMDB00243
name: pyruvate
has only substance units: false
is: CHEBI:15361
boundary condition: false

metaR CYTK4n
name: cytidylate kinase (dCMP,GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110021#
fast: false

metaR r0085
modifier: MODEL1310110021#
product: MODEL1310110021#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
is: SBO:0000176

metaM cbasp e
is: C00438
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: N-Carbamoyl-L-aspartate
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: CHEBI:32814
is: HMDB00828
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d1b96224_2a35_4512_b433_64f3a09fb984
name: _U37519_1_c
initial amount: NaN
is encoded by: hsa:U37519
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_5a8df0e3_a241_40eb_972f_c0475a52bdbe
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:30
has only substance units: false
is: Q96CA6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ACAA1

metaR r0944
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
name: Active transport

metaR UGCG
modifier: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.80
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
is: SBO:0000176
name: Ceramide glucosyltransferase

metaR FAOXC163C164Gm
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaM dctp c
name: dCTP
is: HMDB00998
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: C00458
is: CHEBI:16311
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: SBO:0000247

metaR r0022
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.8.1.7
type: Reaction
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
fast: false
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is: SBO:0000176
reversible: true
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_05a293db_f6a2_47cb_af9f_cd482a9d7b18
is encoded by: hsa:6530
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is: Q96KH8
initial amount: NaN
name: SLC6A2

metaM dcacoa x
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
is: C05274
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: HMDB06404
is: CHEBI:61430
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species

metaR r1615
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR r1728
type: Reaction
is: SBO:0000185
reversible: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_b9b8ecbc_835c_4e93_973e_1006e99f41f6
name: GSR
is encoded by: hsa:2936
has only substance units: false
type: Species
initial concentration: NaN
is: P00390
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR UMPtr
is described by: ECO:0000269
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.7.4.14 Confidence Level: 1 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110021#
product: MODEL1310110021#
name: UMP transport (ER)
kinetic law: MODEL1310110021#
type: Reaction

metaM nadp r
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00006
type: Species
is: HMDB00217
is: CHEBI:58349
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
constant: false

metaR UAG4E
modifier: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
is: SBO:0000176
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000304
name: UDP-N-acetylglucosamine 4-epimerase
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaM lpam m
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
type: Species
name: lipoamide
constant: false
initial concentration: 1.0
is: HMDB00962
has only substance units: false
initial amount: NaN
is: CHEBI:17460

http://identifiers.org/biomodels.db/MODEL1310110021#_daad8234_aa06_4cb4_8279_2beac83228e2
is: P20933
initial amount: NaN
is: SBO:0000252
name: AGA
constant: false
is encoded by: hsa:175
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_91e63fb2_3d81_4599_9f6c_7577eb8a7b29
name: PAICS
is encoded by: hsa:10606
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: P22234

metaR r1596
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#

metaR LEUPHELAT2tc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_003b8329_b904_4062_8b26_b07173653314
constant: false
name: DHODH
is: Q02127
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:1723

http://identifiers.org/biomodels.db/MODEL1310110021#_9f560d24_51f7_40d6_9e7a_f5a80f25d3d7
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: DGKB
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1607

metaR RTOTAL2t
is: SBO:0000185
product: MODEL1310110021#
fast: false
name: RTOTAL2 transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
type: Reaction

metaR r0084
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110021#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaR FAOXC183806m
type: Reaction
is: SBO:0000176
product: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_488b64e6_ab1a_4f84_bfc3_482dcc740c9f
type: Species
boundary condition: true
is encoded by: hsa:5332
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: E2QRH8
name: PLCB4
is: SBO:0000252

metaM 3oddcoa m
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
constant: false
type: Species
is: HMDB03937
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:27868
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_93d9ae8f_4123_4c9a_8da2_85c3fd780079
has only substance units: false
type: Species
initial amount: NaN
name: VNN2
is: O95498
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8875

metaM glu5p m
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58274
name: L-Glutamate 5-phosphate
is: SBO:0000247
type: Species
is: HMDB01228
initial amount: NaN
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287

http://identifiers.org/biomodels.db/MODEL1310110021#_6066e4f5_4784_4b0e_80ea_170aceb72685
is: Q49AT3
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: B3GALNT1
is encoded by: hsa:8706

http://identifiers.org/biomodels.db/MODEL1310110021#_04badf13_cb68_4572_8bb0_b29fab376d7b
is: P05091
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:217
name: ALDH2
type: Species
constant: false

metaR r1597
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_0d84137d_a6f0_4e16_860e_8af790db312c
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:158
is: SBO:0000252
initial amount: NaN
name: ADSL
type: Species
is: P30566

metaR RE1897C
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
fast: false
reactant: MODEL1310110021#
reversible: true
name: RE1897
product: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_916939d7_9760_47ae_a36f_8d3ac144644d
constant: false
name: SLC9A1
boundary condition: true
initial concentration: NaN
type: Species
is: P19634
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6548
initial amount: NaN

metaR r1616
fast: false
modifier: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_cb51200a_16dc_48d6_9e39_2fffcfe13219
is encoded by: hsa:2592
is: SBO:0000252
has only substance units: false
name: GALT
initial amount: NaN
type: Species
boundary condition: true
is: B2RAT6
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_9f1de971_7ec3_4d1a_a115_b9d8112880bc
is: SBO:0000252
constant: false
is encoded by: hsa:8611
is: G3XA95
name: PPAP2A
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false

metaM chol c
type: Species
constant: false
boundary condition: false
is: C00114
initial amount: NaN
is: SBO:0000247
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
name: Choline
is: CHEBI:15354
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_fdcb0022_d5a1_49df_95d7_1f97e389cbdd
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P31939
is encoded by: hsa:471
name: ATIC

metaR CYSGLUexR
reactant: MODEL1310110021#
name: L-cysteine/L-glutamine reversible exchanger
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000304

metaR FAOXC204C184m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaM pi m
is: C00009
constant: false
initial amount: NaN
is: HMDB00973
is: CHEBI:43474
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR r0946
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110021#_e462b216_780d_4dce_9d60_2c7e8301378f
name: HSD17B10
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3028
is: Q99714
has only substance units: false
is: SBO:0000252
type: Species

metaM cbasp c
initial amount: NaN
is: SBO:0000247
is: HMDB00828
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
constant: false
boundary condition: false
is: C00438
name: N-Carbamoyl-L-aspartate
is: CHEBI:32814

http://identifiers.org/biomodels.db/MODEL1310110021#_3757e2e1_ddf8_487d_ba9a_52baa24e2749
is: O43451
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:8972
type: Species
name: MGAM
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_c36163e3_dda7_4518_a914_7fbb77ab9c87
is: B4DK61
name: ACOX1
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:51
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

metaM thf e
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: HMDB01846
is: CHEBI:57453
boundary condition: false
initial concentration: 1.0
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_ed23695d_8d71_4977_9e0d_d76073bd8f21
name: ACAT2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:39
boundary condition: true
is: Q9BWD1
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaR r0083
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
is: SBO:0000176
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR r0242
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.1
reactant: MODEL1310110021#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
is: SBO:0000176
modifier: MODEL1310110021#

metaR RE3244R
fast: false
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
name: RE3244
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000

metaR FAOXC12C10m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaR r0130
is described by: ECO:0000000
type: Reaction
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true

metaR r1262
fast: false
is: SBO:0000176
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000

metaR NRPPHRt4 2 r
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
type: Reaction
name: Norepinephrine reversible transport in via sodium symport (1:2)
modifier: MODEL1310110021#
is: SBO:0000185
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000269

metaM hLkynr c
is: HMDB11631
boundary condition: false
type: Species
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17380
name: 3-hydroxy-L-kynurenine
has only substance units: false

metaR BILDGLCURt
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
type: Reaction
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_edda7847_bdcd_4683_a126_467d529a1395
has only substance units: false
type: Species
initial concentration: NaN
is: P32119
is encoded by: hsa:7001
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: PRDX2

metaM nrpphr e
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00216
is: CHEBI:33569
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial amount: NaN
name: Norepinephrine

metaM ddcacoa m
boundary condition: false
name: Dodecanoyl-CoA (n-C12:0CoA)
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: C01832
is: HMDB03571
constant: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
initial concentration: 1.0
is: CHEBI:57375

metaM icit x
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
is: HMDB00193
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: isocitrate(3-)

metaR NDP7er
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110021#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
reactant: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_63b452f9_17a7_46fd_8dc8_6096ca46a9c2
boundary condition: true
is encoded by: hsa:10005
is: O14734
type: Species
initial amount: NaN
name: ACOT8
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252

metaM CE5162 r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57923
name: trans,cis-2,9-octadecadienoyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_2fa42a34_c857_4bda_aee4_accc2e8f03a0
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:10637
is: SBO:0000252
initial concentration: NaN
is: O75610
boundary condition: true
constant: false
name: LEFTY1

metaM pi r
boundary condition: false
initial amount: NaN
is: HMDB00973
constant: false
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
is: CHEBI:43474
initial concentration: 1.0
has only substance units: false
type: Species
is: C00009
name: hydrogenphosphate

metaR r1617
modifier: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#

metaM but e
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17968
is: SBO:0000247
constant: false

metaR r1722
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000

metaR r0355
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110021#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110021#
reversible: false

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_b06282b8_11c5_4001_a92a_fae72dcd48a1
is encoded by: hsa:AI935189
constant: false
type: Species
name: _AI935189_1_m
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM gthrd e
constant: false
has only substance units: false
is: SBO:0000247
name: glutathionate(1-)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57925
is: HMDB00125
boundary condition: false
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

metaM glyc c
constant: false
is: HMDB00131
name: Glycerol
is: SBO:0000247
is: CHEBI:17754
is: C00116
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

http://identifiers.org/biomodels.db/MODEL1310110021#_c1e19f8e_95cd_42e2_8b3d_74ebf17049ce
has only substance units: false
initial concentration: NaN
type: Species
name: PPA2
is encoded by: hsa:27068
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_cab3b909_067e_4096_992d_0166ee43bf3f
is: SBO:0000252
is encoded by: hsa:728226
name: _728226_1_e
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaM pmtcoa m
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: HMDB01338
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57379
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154

http://identifiers.org/biomodels.db/MODEL1310110021#_9ab4d0f5_c41f_4ab2_bb99_7be4b6365faf
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: DGKD
type: Species
initial concentration: NaN
is: Q16760
is encoded by: hsa:8527
boundary condition: true

metaR SPMS
product: MODEL1310110021#
fast: false
type: Reaction
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.5.1.16
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
is: SBO:0000176
name: spermidine synthase
is described by: ECO:0000269
modifier: MODEL1310110021#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_e9c280aa_c197_4b4c_b316_ce50e3bfec09
is: P15328
name: FOLR1
is encoded by: hsa:2348
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_97d86706_dff7_48a8_aa2e_07301632834f
initial amount: NaN
name: AMACR
initial concentration: NaN
is encoded by: hsa:23600
has only substance units: false
boundary condition: true
constant: false
type: Species
is: Q3KT79
is: SBO:0000252

MODEL1310110021
reaction: metaR EX nad LPAREN e RPAREN
reaction: metaR FAOXC161802m
reaction: metaR RE2999M
species: metaM 4ppcys c
reaction: metaR r1964
reaction: metaR PYRt2r
species: metaM thm c
reaction: metaR ILEPHELAT2tc
species: metaM tdcoa c
reaction: metaR FAOXC183806m
reaction: metaR OAGD3tg
species: metaM dpcoa c
species: metaM 3ohdcoa x
reaction: metaR EX dtmp LPAREN e RPAREN
reaction: metaR LYStip
reaction: metaR r1377
reaction: metaR ASNNm
reaction: metaR DNDPt39m
reaction: metaR r0033
species: metaM ttdca c
species: metaM ctp e
species: metaM phe L e
species: metaM akg x
species: metaM cmp c
species: metaM co2 c
reaction: metaR GRTTx
reaction: metaR ANTHte
species: metaM leuktrB4 e
reaction: metaR RE1709C
reaction: metaR r0915
species: metaM mag hs c
reaction: metaR SPHS1Pte
species: metaM Sfglutth c
species: metaM glx c
reaction: metaR r2367
reaction: metaR r1934
reaction: metaR LEUGLYPEPT1tc
reaction: metaR EX fru LPAREN e RPAREN
reaction: metaR HPYRRy
reaction: metaR RE0926E
reaction: metaR KYNATESYN
reaction: metaR r0670
reaction: metaR EX tsul LPAREN e RPAREN
species: metaM 2hb c
species: metaM HC02187 e
species: metaM dcmp c
species: metaM psyl e
reaction: metaR r1259
species: metaM ctp n
reaction: metaR CDIPTr
reaction: metaR PCHOL HSter
reaction: metaR LTA4H
reaction: metaR H2O2t
species: metaM HC01712 m
reaction: metaR r2194
species: metaM g1p c
reaction: metaR THRGLYexR
species: metaM crn x
species: metaM 5thf e
reaction: metaR EX fald LPAREN e RPAREN
reaction: metaR CYTK1n
reaction: metaR 5ADTSTSTERONEte
reaction: metaR ALCD21 L
species: metaM xol7aone m
reaction: metaR r0630
reaction: metaR MERCPLACCYSt
species: metaM CE0849 m
reaction: metaR RE2974C
reaction: metaR r1622
reaction: metaR r2538
reaction: metaR HMGCOASim
species: metaM eandrstrn r
species: metaM thf e
reaction: metaR r1578
species: metaM xol27oh m
reaction: metaR FAOXC102C103m
reaction: metaR RE0689E
reaction: metaR CLS hs
species: metaM CE2432 m
reaction: metaR BUTt2r

metaR r0669
product: MODEL1310110021#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_3294796a_079c_45e0_aac0_4a9f00d11bdb
initial concentration: NaN
name: PPA1
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: Q15181
has only substance units: false
is encoded by: hsa:5464
type: Species

metaR r0081
modifier: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110021#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_8e4bc574_81a2_4ecc_8a2b_c9a37476e6f9
is encoded by: hsa:1738
name: DLD
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is: P09622
has only substance units: false

metaR XYLtly
reactant: MODEL1310110021#
type: Reaction
fast: false
is described by: ECO:0000000
name: Xylose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
product: MODEL1310110021#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110021#

metaR UGALNACtg
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
name: UDP-GalNAc Golgi transport via CMP antiport
is described by: ECO:0000269
reactant: MODEL1310110021#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
modifier: MODEL1310110021#

metaR r1618
fast: false
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110021#
reactant: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000

metaM coa r
constant: false
is: C00010
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: HMDB01423
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57287

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaR r0870
fast: false
is version of: http://identifiers.org/ec-code/3.6.4.13
name: Facilitated diffusion
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.1.3.4
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
product: MODEL1310110021#

metaR r0354
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110021#

metaR UPPN
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
type: Reaction
product: MODEL1310110021#
fast: false
reversible: false
is described by: ECO:0000269
name: b-ureidopropionase
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.1.6

metaR O2ter
is described by: ECO:0000000
name: O2 transport, endoplasmic reticulum
type: Reaction
is: SBO:0000185
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110021#
fast: false

metaM dmnoncoa x
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
constant: false
is: HMDB11604
type: Species

metaR DMHPTCRNt
reversible: true
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: 2,6 dimethylheptanoyl crn transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
fast: false
reactant: MODEL1310110021#

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM nrpphr c
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
name: Norepinephrine
is: CHEBI:33569
is: HMDB00216

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_0c7597b3_0989_4ebe_aebe_f8aecfd45311
initial concentration: NaN
is encoded by: hsa:AA177072
has only substance units: false
type: Species
initial amount: NaN
name: _AA177072_1_x
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_59976786_4bc0_4c19_bb2f_dae99376e961
boundary condition: true
constant: false
is: Q5JWV8
is encoded by: hsa:2182
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: ACSL4
has only substance units: false
type: Species

metaM hx2coa m
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: HMDB06294
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: trans-Hex-2-enoyl-CoA
type: Species

metaR r1619
kinetic law: MODEL1310110021#
type: Reaction
fast: false
product: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM but c
is: SBO:0000247
constant: false
name: butyrate
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00039
type: Species
is: CHEBI:17968
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_6325a670_4a6d_4ffc_a053_470dc5b2e543
has part: P00338
is: SBO:0000297
constant: false
has only substance units: false
is encoded by: hsa:3945
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3939
has part: P07195
name: LDHA:LDHB

metaM ade e
type: Species
initial concentration: 1.0
name: adenine
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
boundary condition: false
is: CHEBI:16708
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00034

metaR THP2Ctp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
type: Reaction
reversible: true
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
fast: false

metaM zymstnl r
constant: false
initial amount: NaN
is: CHEBI:16608
has only substance units: false
is: HMDB06841
initial concentration: 1.0
name: 5alpha-cholest-8-en-3beta-ol
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845

metaR XYLt
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
reversible: true
name: D-xylose reversible transport

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR r1487
is described by: ECO:0000000
name: EC:6.2.1.3
reactant: MODEL1310110021#
is: SBO:0000176
fast: false
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_82776f6c_c743_444b_a7e2_5dfd021e8d91
constant: false
is encoded by: hsa:2224
is: SBO:0000252
boundary condition: true
type: Species
is: P14324
has only substance units: false
initial concentration: NaN
name: FDPS
initial amount: NaN

metaR VALTAm
name: valine transaminase, mitochondiral
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
kinetic law: MODEL1310110021#
reversible: true
product: MODEL1310110021#

metaR PROSTGE1t
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110021#
reversible: true
product: MODEL1310110021#
type: Reaction
is: SBO:0000185

metaR RNDR2
product: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
type: Reaction
is described by: ECO:0000254
reactant: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
name: ribonucleoside-diphosphate reductase (GDP)
kinetic law: MODEL1310110021#

metaM uacgam c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
boundary condition: false
constant: false
is: CHEBI:57705
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM glyc e
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
constant: false
is: HMDB00131
boundary condition: false
name: Glycerol
is: C00116
has only substance units: false
is: CHEBI:17754
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR RE3001M
name: RE3001
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.1.34

metaR EX phyt LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phytanic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_a4e775cc_58f0_4e19_8ddd_2d7227d91736
constant: false
has only substance units: false
is: E5KSL5
name: DGUOK
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:1716
is: SBO:0000252

metaM andrstandn r
has only substance units: false
is: HMDB00899
is: CHEBI:15994
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 5alpha-androstane-3,17-dione

metaM lac D e
has only substance units: false
type: Species
is: HMDB01311
initial concentration: 1.0
boundary condition: false
name: (R)-lactate
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16004
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1

metaR MANt4
reactant: MODEL1310110021#
name: D-mannose transport via sodium cotransport
kinetic law: MODEL1310110021#
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_1cf0101a_58bb_4c28_9771_79cd768e6e17
is encoded by: hsa:N63787
name: _N63787_1_c
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaM mercplac c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8118
name: 3-Mercaptolactate
is: SBO:0000247
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
initial amount: NaN
constant: false
has only substance units: false
is: HMDB02127
boundary condition: false
is: C05823
type: Species

metaM dd2coa x
type: Species
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57330
name: trans-Dodec-2-enoyl-CoA
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: SBO:0000247
is: HMDB03712
initial concentration: 1.0
initial amount: NaN

metaM strdnc c
name: stearidonic acid C18:4, n-3
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
type: Species
has only substance units: false
is: C16300
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM galgluside hs g
name: galactosyl glucosyl ceramide
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:58223
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
type: Species
boundary condition: false
is: C00015
is: HMDB00295
initial concentration: 1.0
initial amount: NaN

metaR ADMDC
reversible: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110021#
is described by: ECO:0000269
name: adenosylmethionine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.50
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
fast: false

metaR RNDR1
kinetic law: MODEL1310110021#
name: ribonucleoside-diphosphate reductase (ADP)
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is: SBO:0000176
modifier: MODEL1310110021#
type: Reaction
reversible: false
is described by: ECO:0000254
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e045cbd0_95e0_4e1e_809d_1ef5463d088c
initial concentration: NaN
has only substance units: false
name: SLC23A1
type: Species
is encoded by: hsa:9963
is: SBO:0000252
is: Q9UHI7
constant: false
boundary condition: true
initial amount: NaN

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_2aacafe4_e93c_4d58_ab2c_937a308a597c
is encoded by: hsa:4701
initial amount: NaN
has only substance units: false
name: NDUFA7
initial concentration: NaN
is: SBO:0000252
is: Q6FG42
boundary condition: true
type: Species
constant: false

metaR INSTt4 2
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
modifier: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#
name: inositol transport via sodium symport
kinetic law: MODEL1310110021#

metaM pail345p hs c
is: SBO:0000247
constant: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
type: Species
is: CHEBI:57836
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM tdcoa m
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: C02593
boundary condition: false
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: CHEBI:57385

metaR r0666
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
modifier: MODEL1310110021#

metaM akg x
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00208
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-oxoglutarate(2-)
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_14e51de2_8834_48cd_8486_9c91ae25e60e
boundary condition: true
is: C9JT23
is encoded by: hsa:126328
is: SBO:0000252
name: NDUFA11
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_6ace3ea4_c05d_4978_8a41_3f66a921be00
is encoded by: hsa:9056
constant: false
is: SBO:0000252
is: Q9UM01
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC7A7

metaM mi34p c
initial concentration: 1.0
name: 1D-myo-Inositol 3,4-bisphosphate
boundary condition: false
initial amount: NaN
is: HMDB06235
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:28858
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
type: Species

metaR 4HGLSDm
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.1.12
reactant: MODEL1310110021#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000212
type: Reaction
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_10789e23_1346_4a7e_8779_56f1079fc276
boundary condition: true
is: Q99643
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: SDHC
is encoded by: hsa:6391
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_94fdbcd6_2bfa_4ecd_b4a6_208affee888c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: INPP4A
has only substance units: false
is encoded by: hsa:3631
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_aa3bad0f_4df5_4771_9f02_f195cadeff58
constant: false
is: Q9BTU6
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:55361
type: Species
name: PI4K2A
is: SBO:0000252

metaM CE4876 r
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
initial concentration: 1.0
type: Species
name: delta12-Prostaglandin J2
initial amount: NaN
constant: false
is: CHEBI:57923

metaR DPMVDx
reactant: MODEL1310110021#
is described by: ECO:0000134
name: diphosphomevalonate decarboxylase
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
fast: false
kinetic law: MODEL1310110021#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.1.1.33

metaR SCP21cx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaM ade c
is: CHEBI:16708
is: C00147
name: Adenine
boundary condition: false
type: Species
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00034
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_a779cf5d_0eef_44f1_b142_51cc6d878753
constant: false
has only substance units: false
name: COASY
initial concentration: NaN
is: SBO:0000252
is: Q13057
boundary condition: true
initial amount: NaN
is encoded by: hsa:80347
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_59d40a44_60e2_43b5_8e26_b4a334d89bec
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:MBOAT5
name: _MBOAT5_1_c
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_624c5496_d74c_40d5_9822_3264022ab68e
is: Q9HAB8
constant: false
name: PPCS
initial amount: NaN
is encoded by: hsa:79717
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaM dhap x
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:57642
name: Dihydroxyacetone phosphate
is: http://identifiers.org/pubchem.compound/3411
is: HMDB01473
boundary condition: false
constant: false
is: C00111
is: SBO:0000247
type: Species

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaM tsul m
is: HMDB00257
name: thiosulfate(2-)
initial concentration: 1.0
is: CHEBI:16094
has only substance units: false
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
is: SBO:0000247
constant: false
boundary condition: false

metaR SO4t4 2
reversible: true
type: Reaction
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000269
product: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
name: sulfate transport via sodium symport
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_8031e431_9838_4f71_a5b8_5f02bc0a231c
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6568
is: Q14916
initial concentration: NaN
name: SLC17A1
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_be610c7b_2698_4da3_b4fe_96c563f23c05
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:121278
has only substance units: false
boundary condition: true
is: Q8IWU9
name: TPH2
type: Species
initial amount: NaN

metaR DOLGPP Ler
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
name: Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (liver)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.4.48 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110021#
fast: false

metaM pyr m
is: C00022
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: CHEBI:15361
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
is: HMDB00243
name: pyruvate
type: Species

metaR r1819
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110021#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_dfa4c30d_308c_4932_8661_040cd105c2f6
initial amount: NaN
is encoded by: hsa:157570
constant: false
name: ESCO2
is: Q56NI9
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaM 2dodtricoa m
constant: false
is: C05280
initial concentration: 1.0
name: 2,6,9-dodecatrienoylcoa
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: HMDB03952
has only substance units: false
is: SBO:0000247
boundary condition: false

metaR FATP7t
name: fatty acid electroneutral transport
fast: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ

http://identifiers.org/biomodels.db/MODEL1310110021#_88893804_cb7e_4bbc_8cad_fd195a74fd94
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is: P27707
initial amount: NaN
is encoded by: hsa:1633
has only substance units: false
name: DCK

http://identifiers.org/biomodels.db/MODEL1310110021#_3510f21c_5185_4c67_9a01_4109c53cdebc
is encoded by: hsa:51727
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: CMPK1
type: Species
has only substance units: false
initial amount: NaN
is: B2R6S5

metaM lac D c
is: CHEBI:16004
name: (R)-lactate
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01311

http://identifiers.org/biomodels.db/MODEL1310110021#_dfa2e953_af44_4753_bb60_5abbc44e3c72
has only substance units: false
is: O00767
is encoded by: hsa:6319
boundary condition: true
name: SCD
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR r0668
is: SBO:0000176
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.4.2.19
modifier: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:

metaM dutp m
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
has only substance units: false
is: SBO:0000247
constant: false
name: dUTP
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB01191
boundary condition: false

metaR r1260
product: MODEL1310110021#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110021#
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_09f47c6c_3148_45c5_a03c_c8d357f5d862
is: Q6UWQ5
is encoded by: hsa:84569
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: LYZL1
constant: false
initial concentration: NaN

metaR ACCOAtn
reactant: MODEL1310110021#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110021#
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: acetyl-CoA transport, nuclear
is described by: ECO:0000000
type: Reaction

metaM CE5586 c
boundary condition: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
is: CHEBI:58732

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_082efc15_a0e3_49b3_8c15_b17fe977f8f2
name: ACAT1
type: Species
is: P24752
initial amount: NaN
is encoded by: hsa:38
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaR LNLNCAt
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
name: fatty acid transport via diffusion
reactant: MODEL1310110021#
fast: false

metaM gthrd c
name: Reduced glutathione
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: C00051
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00125
is: CHEBI:57925

metaM btamp c
is: CHEBI:3110
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
initial amount: NaN
type: Species
name: Biotinyl-5'-AMP
is: SBO:0000247
constant: false

metaM ptth c
is: SBO:0000247
name: pantetheine
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:16753
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: HMDB03426
constant: false

metaR r0027
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
fast: false
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.39
is: SBO:0000176
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction

metaR ALDD21
name: aldehyde dehydrogenase (pristanal, NAD)
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
modifier: MODEL1310110021#
reversible: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (224.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:8528251 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000304

metaM glyc3p x
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Glycerol 3-phosphate
type: Species
is: HMDB00126
is: CHEBI:57597
constant: false
initial concentration: 1.0
is: C00093
boundary condition: false

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_b53e7ced_201c_445d_86e8_108a72ac8df5
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5464
constant: false
name: PPA1
is: Q15181
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaM dutp n
constant: false
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
initial amount: NaN
type: Species
is: HMDB01191
name: dUTP
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM cholcoa c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57373
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
type: Species
is: HMDB01374
boundary condition: false
has only substance units: false
initial amount: NaN
name: choloyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110021#_95d6f109_5c7e_44a8_9c86_34af3cd32891
is: SBO:0000252
is: Q86V21
initial concentration: NaN
name: AACS
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:65985

http://identifiers.org/biomodels.db/MODEL1310110021#_fb54f53a_7a7b_46db_b145_8061a61af698
is encoded by: hsa:23657
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000297
initial amount: NaN
has only substance units: false
has part: Q9UPY5
name: SLC7A11:SLC3A2

metaR ETF
fast: false
modifier: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
type: Reaction
reactant: MODEL1310110021#
reversible: false
product: MODEL1310110021#
is: SBO:0000176
name: electron transfer flavoprotein
kinetic law: MODEL1310110021#

metaM dsmsterol r
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
is: CHEBI:17737
is: HMDB02719
name: desmosterol
constant: false
has only substance units: false
initial concentration: 1.0

metaM thf m
is: HMDB01846
is: CHEBI:57453
is: C00101
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_85f21708_5faa_4a6c_b7fc_ae79f0e892d2
type: Species
name: ACSL4
is: SBO:0000252
constant: false
is: O60488
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2182
initial amount: NaN

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR PYNP2r
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.3
name: pyrimidine-nucleoside phosphorylase (uracil)
modifier: MODEL1310110021#
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2

http://identifiers.org/biomodels.db/MODEL1310110021#_715c1565_3fe4_48f5_bb00_14a9b78e06de
has only substance units: false
name: NT5M
initial concentration: NaN
type: Species
is encoded by: hsa:56953
boundary condition: true
initial amount: NaN
is: Q9NPB1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_388f9869_cbc8_4eb9_abaf_f67edd548d36
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: B3GALT5
boundary condition: true
is encoded by: hsa:10317
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1c017e44_e97c_49c4_b82b_8ac8f6e26e87
initial concentration: NaN
constant: false
is encoded by: hsa:AU149534
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
name: _AU149534_1_m

http://identifiers.org/biomodels.db/MODEL1310110021#_a49efa28_b727_4a55_a40b_a7c65833b8e0
name: DGKB
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1607
constant: false
is: Q9Y6T7
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaR AICART
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reactant: MODEL1310110021#
reversible: true
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.3
type: Reaction
fast: false
kinetic law: MODEL1310110021#

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaR RE1448N
is described by: ECO:0000000
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
reversible: true
name: RE1448
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
kinetic law: MODEL1310110021#
is: SBO:0000176

metaM ca2 e
name: calcium(2+)
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00464
is: CHEBI:29108
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_b2c4e86c_89e6_4d70_9521_42504965fe54
has only substance units: false
constant: false
name: UPP1
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:7378
is: SBO:0000252
initial amount: NaN

metaR AMPtp
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: AMP transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reactant: MODEL1310110021#
fast: false

metaM 3hpcoa m
initial amount: NaN
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807
constant: false
is: CHEBI:58528
is: SBO:0000247
name: 3-hydroxypropanoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

metaM 44mzym r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: SBO:0000247
type: Species
boundary condition: false
name: 14-demethyllanosterol
is: CHEBI:18364
constant: false
is: HMDB01286
initial amount: NaN

metaM c4crn c
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: C02862
constant: false
name: butyryl carnitine
initial amount: NaN
is: http://identifiers.org/pubchem.compound/213144
is: HMDB02013
initial concentration: 1.0
notes: FORMULA: C11H21NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110021#_7ca33512_0a29_48af_87e2_7e87f71c6161
is: SBO:0000252
type: Species
is: Q9HAS3
initial amount: NaN
constant: false
name: SLC28A3
has only substance units: false
is encoded by: hsa:64078
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_adc53914_2d29_4617_b231_6331d3cd63d3
constant: false
is: P11168
initial concentration: NaN
type: Species
name: SLC2A2
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6514

metaR r1018
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
product: MODEL1310110021#
reversible: true
type: Reaction
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_5421053f_e7f8_4995_b9a7_f2d3a93b527c
has only substance units: false
initial amount: NaN
constant: false
is: P50747
name: HLCS
type: Species
initial concentration: NaN
is encoded by: hsa:3141
is: SBO:0000252
boundary condition: true

metaR r2534
reactant: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
fast: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_a9212a4e_c676_40a4_90c8_2f60d11e7b82
has only substance units: false
is: SBO:0000252
is: P28329
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: CHAT
initial concentration: NaN
is encoded by: hsa:1103

metaR r0651
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110021#
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR Htg
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: proton diffusion (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false

metaR NDPK3n
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_6ee2c2f9_a2ee_435d_8d26_507500415da4
initial concentration: NaN
boundary condition: true
is encoded by: hsa:343
has only substance units: false
name: AQP8
is: SBO:0000252
initial amount: NaN
is: O94778
type: Species
constant: false

metaM dcacoa m
initial amount: NaN
is: HMDB06404
constant: false
is: C05274
is: SBO:0000247
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
boundary condition: false
is: CHEBI:61430
name: Decanoyl-CoA (n-C10:0CoA)
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_48eef1be_9382_4b8a_903e_f306fbeedd3f
constant: false
type: Species
boundary condition: true
name: SLC26A1
is: Q9H2B4
initial concentration: NaN
is encoded by: hsa:10861
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR MTHFC
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
modifier: MODEL1310110021#
name: methenyltetrahydrofolate cyclohydrolase
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
kinetic law: MODEL1310110021#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is version of: http://identifiers.org/ec-code/1.5.1.5

http://identifiers.org/biomodels.db/MODEL1310110021#_3c3e588d_731b_4367_8dd9_83796f59b91c
is encoded by: hsa:8706
name: B3GALNT1
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q8TDY1

http://identifiers.org/biomodels.db/MODEL1310110021#_c7dcd1eb_b264_4518_8155_54f395e64fce
has only substance units: false
initial amount: NaN
is encoded by: hsa:HG2846-HT2983
type: Species
name: _HG2846_HT2983_1_c
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM pi x
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:43474
constant: false
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
type: Species
boundary condition: false
is: HMDB00973
is: SBO:0000247
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110021#_3a606cca_fc66_4074_8148_248530d7caf8
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4723
name: NDUFV1
constant: false
initial amount: NaN
is: SBO:0000252
is: E5KNH5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_d8fd29a9_7222_420e_9b0d_1399aaab8aed
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: Q9H2U2
initial concentration: NaN
name: PPA2
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110021#_b1193b7d_8b20_4a4b_8519_4b3fdf6765ab
boundary condition: true
is: Q9UBM1
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: PEMT
is encoded by: hsa:10400
initial amount: NaN

metaR r2535
is described by: ECO:0000000
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110021#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaM accoa g
boundary condition: false
name: acetyl-CoA(4-)
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01206
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
type: Species

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_1004150f_a5e6_455d_8912_159dc8bdc06a
is encoded by: hsa:124
initial concentration: NaN
type: Species
is: SBO:0000297
has only substance units: false
has part: P07327
name: ADH1A:ADH1B
initial amount: NaN
constant: false
boundary condition: true

metaR APOC LYS BTNP
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
type: Reaction
name: proteolysis of apoC-Lys-btn
reversible: false
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#

metaM coumarin e
boundary condition: false
has only substance units: false
is: CHEBI:28794
notes: FORMULA: C9H6O2 CHARGE: 0 INCHI: InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
is: SBO:0000247
is: HMDB01218
initial concentration: 1.0
initial amount: NaN
name: coumarin
type: Species
constant: false

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_af08e305_bc8d_40b7_9d9d_36ebad30dbcc
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:47
is: SBO:0000252
name: ACLY

http://identifiers.org/biomodels.db/MODEL1310110021#_418189db_368a_41a2_94f5_c59157096bc4
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: SLC6A10P
boundary condition: true
is encoded by: hsa:386757

http://identifiers.org/biomodels.db/MODEL1310110021#_3939b841_00c9_4152_aaa5_9a051f8d7a93
initial concentration: NaN
has only substance units: false
name: AK5
boundary condition: true
is: SBO:0000252
is: Q9Y6K8
initial amount: NaN
constant: false
is encoded by: hsa:26289
type: Species

metaM pro D e
type: Species
boundary condition: false
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB03411
is: CHEBI:16313
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_76c4243e_cb55_4359_8553_62a74fc5530e
type: Species
name: ATG9B
is: Q674R7
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:285973
initial amount: NaN
boundary condition: true

metaM HC02216 c
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: prostaglandin-f2beta
is: SBO:0000247
is: CHEBI:28922
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
has only substance units: false

metaM fum m
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00134
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:29806
is: C00122
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122

http://identifiers.org/biomodels.db/MODEL1310110021#_3905fedd_11fb_4350_993e_098a12bd3556
has only substance units: false
boundary condition: true
is: SBO:0000297
is encoded by: hsa:23428
constant: false
initial concentration: NaN
name: SLC7A8:SLC3A2
initial amount: NaN
has part: Q9UHI5
type: Species

metaR FACOAL224
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110021#
is described by: ECO:0000000
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110021#_8fd9638a_962a_47a7_ab9a_d54d424c847a
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:BC005314
has only substance units: false
constant: false
name: _BC005314_1_x

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR r2532
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_7873d938_c1b0_42f7_ae31_d7868f1b3a92
is encoded by: hsa:89874
has only substance units: false
initial amount: NaN
type: Species
is: G3V4L5
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC25A21

metaM chol m
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00097
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
name: choline
is: CHEBI:15354
has only substance units: false
type: Species
initial concentration: 1.0

metaR r0504
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
fast: false
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_956c613c_177c_4415_9553_2172b62683fd
has only substance units: false
initial amount: NaN
is encoded by: hsa:3037
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: HAS2
is: Q92819

metaR DNDPt16m
modifier: MODEL1310110021#
is described by: ECO:0000269
name: dUDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000185
reversible: false
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction

metaM HC02202 e
boundary condition: false
initial concentration: 1.0
is: CHEBI:57398
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
has only substance units: false
initial amount: NaN
constant: false

metaR PHYHx
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
is version of: http://identifiers.org/ec-code/1.14.11.18
type: Reaction
name: Phytanoyl-CoA dioxygenase, peroxisomal
is: SBO:0000176
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
reversible: false
product: MODEL1310110021#
is described by: ECO:0000269
kinetic law: MODEL1310110021#

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaM ca2 c
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: calcium(2+)
is: HMDB00464
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_f9f6215f_120d_4cc7_9a21_6d0a69a34344
initial amount: NaN
boundary condition: true
is: Q38G75
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:2582
is: SBO:0000252
name: GALE
constant: false

metaR RE0688E
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110021#
name: RE0688
modifier: MODEL1310110021#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.3.22

metaR PCHOL HSter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
type: Reaction
kinetic law: MODEL1310110021#
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
name: phosphatidylcholine scramblase
reversible: true
reactant: MODEL1310110021#

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_266ddedb_ec0b_44a5_902d_f4db3281f704
is encoded by: hsa:9517
initial concentration: NaN
constant: false
is: SBO:0000297
type: Species
initial amount: NaN
boundary condition: true
has part: O15269
has only substance units: false
name: SPTLC1:SPTLC2
has part: O15270
is encoded by: hsa:10558

metaR LTC4CP
kinetic law: MODEL1310110021#
name: Leukotriene C4 carboxypeptidase
fast: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ

metaR r0650
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.1.1.36
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
product: MODEL1310110021#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaM 1pipdn2c x
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
initial amount: NaN
has only substance units: false
is: HMDB01084
name: 1-piperideine-2-carboxylate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:16187
type: Species

metaM dcsptn1 e
is: HMDB13123
constant: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoic acid
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5282848
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-

http://identifiers.org/biomodels.db/MODEL1310110021#_1aa19a7e_360e_4c7b_8e01_f14263ac11a3
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: ALDH9A1
initial amount: NaN
is encoded by: hsa:223
is: P49189
has only substance units: false
boundary condition: true

metaM dctp n
initial concentration: 1.0
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial amount: NaN
constant: false
name: dCTP
has only substance units: false
is: CHEBI:16311
is: SBO:0000247
is: HMDB00998
boundary condition: false
is: C00458

metaM coumarin c
boundary condition: false
constant: false
is: CHEBI:28794
initial concentration: 1.0
is: SBO:0000247
is: HMDB01218
name: coumarin
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C9H6O2 CHARGE: 0 INCHI: InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H

metaM btn m
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00030
type: Species
initial concentration: 1.0
name: biotinate
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: SBO:0000247
is: CHEBI:57586
constant: false

metaR r2420
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
kinetic law: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000000
product: MODEL1310110021#

metaR GCHOLAte
name: bile acid intracellular transport
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110021#

metaR MHISOR
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)
reactant: MODEL1310110021#
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.3.21
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false

metaR r1816
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
modifier: MODEL1310110021#

metaR MTHFD
is: SBO:0000176
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP)
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.5
reversible: true
modifier: MODEL1310110021#

metaM chol n
name: choline
is: HMDB00097
type: Species
is: CHEBI:15354
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaR DOLGLCP Lter
reversible: false
type: Reaction
is described by: ECO:0000000
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
is: SBO:0000185
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaR CERT2rt
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reversible: true
fast: false
type: Reaction
is: SBO:0000185
name: ceramide transport protein
modifier: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR MALTt1r
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
name: maltose transport (uniport)

metaR FUMTSULtm
is: SBO:0000185
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110021#
is described by: ECO:0000269
modifier: MODEL1310110021#
name: Fumarate:thiosulfate antiport, mitochondrial

metaM pro D c
boundary condition: false
type: Species
name: D-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:16313
is: HMDB03411

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM HC00900 c
is: SBO:0000247
type: Species
is: CHEBI:30860
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
name: Methylmalonate

metaR r2538
kinetic law: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110021#
type: Reaction
name: Utilized transport
reversible: true
reactant: MODEL1310110021#
fast: false
is: SBO:0000185

metaM Ser Gly Ala X Gly l
is: SBO:0000247
constant: false
is: CHEBI:36005
initial amount: NaN
name: protein-linked serine residue (glycosaminoglycan attachment site)
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
is: HMDB02183
type: Species

metaR r1014
name: Postulated transport reaction
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
reversible: false
kinetic law: MODEL1310110021#
fast: false
type: Reaction
reactant: MODEL1310110021#

metaM xolest2 hs e
name: cholesterol ester
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:17002
initial concentration: 1.0
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
type: Species

metaM CE5236 c
initial concentration: 1.0
is: CHEBI:28002
initial amount: NaN
is: HMDB03952
has only substance units: false
is: SBO:0000247
name: O2'-4a-cyclic-tetrahydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
type: Species
constant: false
boundary condition: false

metaM asp L m
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial concentration: 1.0
initial amount: NaN
is: HMDB00191
is: CHEBI:29991
has only substance units: false
name: L-aspartate(1-)
boundary condition: false
is: SBO:0000247
constant: false
type: Species

metaM nadp c
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58349
type: Species
is: C00006
boundary condition: false
initial amount: NaN
constant: false
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217

metaR O16G2e
name: oligo-1,6-glucosidase (strch2 ->strch3), extracellular
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reversible: false
is: SBO:0000176
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.1.10
modifier: MODEL1310110021#
fast: false

metaM HC01401 x
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
constant: false
is: CHEBI:27668
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM debrisoquine e
boundary condition: false
type: Species
notes: FORMULA: C10H14N3 CHARGE: 1 INCHI: InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
initial amount: NaN
is: HMDB06543
initial concentration: 1.0
name: debrisoquine
is: CHEBI:34665
constant: false
has only substance units: false
is: SBO:0000247

metaR LEUKTRD4t
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
is: SBO:0000185
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000269
name: leukotriene D4 transport
type: Reaction
fast: false

metaR KHK2
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.3
is described by: ECO:0000269
name: ketohexokinase (D-xylulose)

metaM HC02202 c
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
is: CHEBI:57398
name: prostaglandin A1(1-)
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR RE3003M
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
product: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110021#
name: RE3003

http://identifiers.org/biomodels.db/MODEL1310110021#_067382ea_6aff_4691_a5fc_7cdbd691d846
is encoded by: hsa:6483
initial concentration: NaN
name: ST3GAL2
is: SBO:0000252
constant: false
has only substance units: false
is: Q16842
initial amount: NaN
type: Species
boundary condition: true

metaR EX onpthl LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: naphthalene epoxide exchange
type: Reaction

metaM ha l
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
name: hyaluronan
initial concentration: 1.0
constant: false
is: CHEBI:16336

metaM adn m
initial concentration: 1.0
is: CHEBI:16335
initial amount: NaN
boundary condition: false
name: adenosine
type: Species
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00050

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_45ba7fd7_31af_4e01_803d_2f2e94fcd3fc
is encoded by: hsa:10723
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC12A7
is: Q9Y666
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_146f471c_9577_4d2d_9c7e_af141654c4a0
type: Species
name: PGK2
is: P07205
is: SBO:0000252
is encoded by: hsa:5232
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR DURIt
fast: false
name: deoxyuridine transport via diffusion
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110021#
is: SBO:0000185

metaM CE2434 m
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57795
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
boundary condition: false
constant: false

metaM CE2838 e
initial concentration: 1.0
constant: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/5041
is: SBO:0000247
is: C01936
name: maltononaose

http://identifiers.org/biomodels.db/MODEL1310110021#_9176efc1_708d_4c98_9113_ae3e95dbf2a1
initial amount: NaN
type: Species
initial concentration: NaN
name: _H53099_1_m
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:H53099

http://identifiers.org/biomodels.db/MODEL1310110021#_ef0ddca6_c091_4f04_98ec_a9d1530e3f09
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: GGT3P
boundary condition: true
has only substance units: false
is encoded by: hsa:2679
constant: false

metaR C40CPT1
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_3e1c6b78_25c0_4069_ac9e_4c8542a092ed
boundary condition: true
is encoded by: hsa:AA664770
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _AA664770_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_3d1264c9_234e_4189_a8a5_34da9057b785
is encoded by: hsa:23007
name: PLCH1
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q4KWH8
is: SBO:0000252
type: Species

metaR LEUTA
name: leucine transaminase
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000269
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42

metaM phyt c
constant: false
initial concentration: 1.0
name: phytanate
boundary condition: false
is: SBO:0000247
is: HMDB00801
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: CHEBI:37257
type: Species
has only substance units: false

metaM Lcystin e
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00192
initial amount: NaN
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
is: CHEBI:16283
initial concentration: 1.0
type: Species
has only substance units: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM accoa c
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
is: HMDB01206
name: Acetyl-CoA
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57288
type: Species
is: C00024
is: SBO:0000247

metaR r1013
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
reactant: MODEL1310110021#
reversible: false
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: Transport reaction

metaM icit m
is: CHEBI:16087
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: Isocitrate
type: Species
constant: false
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial concentration: 1.0
is: HMDB00193
is: C00311

metaM 3docopencoa m
constant: false
is: HMDB06294
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
type: Species
name: 3,7,10,13,16-docosapentenoylcoa

metaR GASNASE2ly
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110021#
reversible: false
name: glycosylasparaginase, lysosomal
reactant: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.1.26
product: MODEL1310110021#

metaM c4crn e
notes: FORMULA: C11H21NO4 CHARGE: 0
is: C02862
is: SBO:0000247
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02013
name: butyryl carnitine
type: Species

metaM adprbp e
is: CHEBI:58673
is: SBO:0000247
initial amount: NaN
is: HMDB06336
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C15H20N5O17P3 CHARGE: -4 INCHI: InChI=1S/C15H24N5O17P3/c16-12-7-13(18-3-17-12)20(4-19-7)14-11(35-38(25,26)27)9(23)6(33-14)2-32-39(28,29)37-40(30,31)36-15-10(24)8(22)5(1-21)34-15/h3-6,8-11,14-15,21-24H,1-2H2,(H,28,29)(H,30,31)(H2,16,17,18)(H2,25,26,27)/p-4/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C03246
constant: false
name: ADP-D-ribose 2'-phosphate(4-)
initial concentration: 1.0

metaR CREATt4 2 r
reversible: true
kinetic law: MODEL1310110021#
name: Creatine transport (sodium symport) (2:1)
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
modifier: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000269
reactant: MODEL1310110021#

metaM nadp e
initial concentration: 1.0
name: NADP+(3-)
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 INCHI: InChI=1S/C21H28N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39)/p-3/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
initial amount: NaN
is: CHEBI:58349
type: Species
is: HMDB00217
has only substance units: false
constant: false

metaM phyt e
initial concentration: 1.0
is: HMDB00801
name: phytanate
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
is: SBO:0000247
is: CHEBI:37257
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false

metaM adp n
boundary condition: false
initial concentration: 1.0
is: CHEBI:456216
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
name: ADP(3-)
is: HMDB01341
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_e6aa1969_8b54_4fea_9945_de923dac3157
has only substance units: false
is: SBO:0000252
name: ADH6
type: Species
is encoded by: hsa:130
boundary condition: true
is: P28332
initial amount: NaN
initial concentration: NaN
constant: false

metaR SERGLNexR
type: Reaction
reversible: true
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000304
reactant: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
name: L-Serine/Glutamine reversible exchange

metaM debrisoquine c
has only substance units: false
notes: FORMULA: C10H14N3 CHARGE: 1 INCHI: InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
constant: false
initial concentration: 1.0
is: HMDB06543
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:34665
type: Species
name: debrisoquine

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_048f0ae2_6e89_4971_8e76_731f07782e74
initial concentration: NaN
name: GGT5
has only substance units: false
initial amount: NaN
type: Species
is: P36269
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2687
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f8af28a9_1813_41d3_8bc0_7917338b2e7c
boundary condition: true
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9GZR5
name: ELOVL4
is encoded by: hsa:6785
initial concentration: NaN

metaR r1012
is: SBO:0000185
reversible: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12543708,PMID:17034878 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_ef801f59_4f0b_4186_9165_64270bd29e37
is: Q59HH3
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: GART
type: Species
is encoded by: hsa:2618
is: SBO:0000252

metaM aicar e
is: C04677
is: HMDB01517
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: CHEBI:58475
type: Species
initial amount: NaN

metaR r1964
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
reversible: false

metaM ru5p D r
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
type: Species
constant: false
initial concentration: 1.0
is: HMDB00618
boundary condition: false
has only substance units: false
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
is: CHEBI:58121

http://identifiers.org/biomodels.db/MODEL1310110021#_6946972c_a15b_4838_b7a7_73e124c66e11
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:3706
is: P23677
initial amount: NaN
initial concentration: NaN
name: ITPKA

metaR GLNtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
fast: false
is: SBO:0000185
name: Glutamine transport (Na, H coupled)
kinetic law: MODEL1310110021#
is described by: ECO:0000269
reversible: true

metaM ump n
type: Species
constant: false
name: UMP(2-)
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00288
boundary condition: false
initial amount: NaN

metaM xoldiolone r
has only substance units: false
boundary condition: false
type: Species
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
is: HMDB02197
constant: false
initial concentration: 1.0
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
is: SBO:0000247
is: CHEBI:28477
initial amount: NaN

metaR r2537
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR NRVNCt
reactant: MODEL1310110021#
fast: false
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110021#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110021#

metaM adp m
type: Species
initial amount: NaN
has only substance units: false
is: C00008
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
name: ADP
is: CHEBI:456216
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM HC02216 e
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: prostaglandin-f2beta
initial amount: NaN
is: CHEBI:28922
is: SBO:0000247
constant: false

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR GTHDH
reversible: false
is described by: ECO:0000134
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
name: Glutathione dehydrogenase (dehydroascorbate reductase)
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2

http://identifiers.org/biomodels.db/MODEL1310110021#_80dbcf8e_4787_487c_9998_c1b3628f4e23
name: OGDHL
initial amount: NaN
is: Q9ULD0
is: SBO:0000252
type: Species
is encoded by: hsa:55753
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false

metaR r0885
is version of: http://identifiers.org/ec-code/1.3.1.38
fast: false
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
modifier: MODEL1310110021#

metaR r0596
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
product: MODEL1310110021#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e371fd13_750b_489e_be9f_5d506270313a
is encoded by: hsa:2746
has only substance units: false
is: SBO:0000252
constant: false
name: GLUD1
initial amount: NaN
is: E9KL48
type: Species
initial concentration: NaN
boundary condition: true

metaM Lcystin c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
type: Species
is: HMDB00192
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16283
name: L-cystine

metaR r1011
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12543708 NOTES:
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
name: Transport reaction
product: MODEL1310110021#

metaR DHCR242r
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
fast: false
is described by: ECO:0000134
modifier: MODEL1310110021#
name: 24-dehydrocholesterol reductase [Precursor]
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.72

metaR C160CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
product: MODEL1310110021#
name: C160 transport into the mitochondria
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000269

metaR r0723
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.41

metaR r2373
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_8e452487_0527_427c_beb3_cc38ff5ef7c5
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: ALDH1A3
is: P47895
initial amount: NaN
is encoded by: hsa:220
initial concentration: NaN
boundary condition: true

metaR PHACCOAGLNAC
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaM HC02214 e
type: Species
initial amount: NaN
name: prostaglandin-f1alpha
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
constant: false
initial concentration: 1.0
is: CHEBI:28852
boundary condition: false

metaR HXPRT
reactant: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.8
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
product: MODEL1310110021#

metaM hexdicoa r
name: hexadecanedioylcoa
is: HMDB00672
is: SBO:0000247
is: C08260
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C37H59N7O19P3S CHARGE: -5

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaM btcoa m
is: CHEBI:57371
is: C00136
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
name: Butanoyl-CoA
is: HMDB01088
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR ASNNm
modifier: MODEL1310110021#
is described by: ECO:0000254
kinetic law: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
reactant: MODEL1310110021#
reversible: false
fast: false
product: MODEL1310110021#
name: L-asparaginase (mitochondrial)
is version of: http://identifiers.org/ec-code/3.5.1.1
type: Reaction

metaM ump c
is: SBO:0000247
has only substance units: false
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: C00105
initial amount: NaN
constant: false
is: HMDB00288
is: CHEBI:57865
type: Species
boundary condition: false
initial concentration: 1.0

metaR APAT2rm
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110021#
reversible: true
is: SBO:0000176
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.19
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
fast: false
is described by: ECO:0000212

metaR GALT
reversible: true
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.12
kinetic law: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
name: galactose-1-phosphate uridylyltransferase
product: MODEL1310110021#
is: SBO:0000176

metaR r2038
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR URAt
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
name: uracil transport via facilated diffusion
type: Reaction
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
fast: false

metaR ADK3m
kinetic law: MODEL1310110021#
name: adentylate kinase (GTP)
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.10
product: MODEL1310110021#
reversible: true
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000176
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110021#_e0429864_9619_4186_ab73_dee0b5cc6949
initial concentration: NaN
has only substance units: false
is encoded by: hsa:123041
constant: false
name: SLC24A4
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

metaR r0722
is described by: ECO:0000000
fast: false
modifier: MODEL1310110021#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.3.12
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR r2372
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM dlnlcg c
type: Species
constant: false
boundary condition: false
is: CHEBI:53486
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
name: dihomo-gamma-linolenic acid (n-6)
is: HMDB02925

metaM dhbpt c
type: Species
initial concentration: 1.0
is: CHEBI:20680
initial amount: NaN
is: SBO:0000247
name: 6,7-dihydrobiopterin
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
constant: false
has only substance units: false
is: HMDB00038
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_504e14b7_ef50_4e26_b05c_9fbb0c33b56b
is: Q7GXY8
constant: false
initial concentration: NaN
type: Species
name: COX1
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4512
is: SBO:0000252

metaM o2 c
constant: false
type: Species
initial amount: NaN
is: CHEBI:15379
has only substance units: false
boundary condition: false
name: O2
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
is: SBO:0000247
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110021#_03c07d87_83cd_42c6_8481_dc7c230bc143
name: ASNS
boundary condition: true
constant: false
is encoded by: hsa:440
initial concentration: NaN
is: B4DXZ1
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_d2aaf18f_2734_4205_b9d2_77c858844ffb
is encoded by: hsa:3633
initial amount: NaN
has only substance units: false
name: INPP5B
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is: P32019
type: Species

metaR GALU
kinetic law: MODEL1310110021#
fast: false
product: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.9
name: UTP-glucose-1-phosphate uridylyltransferase
modifier: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_1291fbcb_c742_4854_a32e_29565eb89bdf
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9BZW2
initial concentration: NaN
is encoded by: hsa:6561
type: Species
name: SLC13A1
is: SBO:0000252

metaM adp c
is: http://identifiers.org/pubchem.compound/3310
is: CHEBI:16761
name: ADP
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01341
is: SBO:0000247
is: C00008
type: Species

metaR r0594
reactant: MODEL1310110021#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
modifier: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:

metaR r1377
reversible: true
is: SBO:0000176
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
fast: false
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is described by: ECO:0000000
kinetic law: MODEL1310110021#

metaR r0441
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
fast: false
reversible: true
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
type: Reaction

metaR GLCAASE8ly
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110021#
is described by: ECO:0000269
name: beta-glucuronidase, lysosomal
fast: false
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR ACOAO7p
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
fast: false
modifier: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000269
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR DURIPP
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
name: deoxyuridine phosphorylase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.4.2.3
fast: false
reversible: true

metaM dcacoa c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06404
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial amount: NaN
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430
constant: false
is: C05274
boundary condition: false
type: Species

metaR r2371
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_106a87d7_aa47_46b7_b9ea_c029f4db1220
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P19367
initial amount: NaN
is encoded by: hsa:3098
type: Species
name: HK1

http://identifiers.org/biomodels.db/MODEL1310110021#_d904e4d8_b797_412b_a75f_503d823c3d77
initial concentration: NaN
has only substance units: false
is encoded by: hsa:257068
boundary condition: true
is: Q0VAA5
name: PLCXD2
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

metaR ALADGLYexR
product: MODEL1310110021#
name: D-alanine/glycine reversible exchange
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110021#

metaR HDCAtr
is described by: ECO:0000000
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reversible: true
fast: false
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaM lnlccrn m
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
constant: false
name: Linoleyl carnitine
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06469
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_6b1f5370_42f7_4616_b439_4c719dd11c07
is encoded by: hsa:1666
constant: false
is: Q16698
is: SBO:0000252
initial concentration: NaN
type: Species
name: DECR1
boundary condition: true
initial amount: NaN
has only substance units: false

metaM HC02214 c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
boundary condition: false
constant: false
name: prostaglandin-f1alpha
has only substance units: false
is: CHEBI:28852
type: Species
initial concentration: 1.0

metaM btn c
boundary condition: false
has only substance units: false
is: C00120
constant: false
initial amount: NaN
is: HMDB00030
type: Species
initial concentration: 1.0
is: CHEBI:3420
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
name: Biotin

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_879f4961_b814_4472_81b8_7d798f24cbc2
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2739
boundary condition: true
name: GLO1
is: Q04760
initial amount: NaN

metaM chol e
boundary condition: false
has only substance units: false
type: Species
name: Choline
is: CHEBI:15354
constant: false
is: HMDB00097
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC102C101m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR r1375
reversible: false
name: Transport reaction
is: SBO:0000185
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false

metaR RE0926E
modifier: MODEL1310110021#
reversible: true
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17

metaR r0724
fast: false
kinetic law: MODEL1310110021#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is: SBO:0000176
type: Reaction
modifier: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaM CE5119 m
has only substance units: false
constant: false
boundary condition: false
name: trans-3-cis-8-tetradecadienoyl-CoA
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57923
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119

metaM C02528 c
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: SBO:0000247
is: CHEBI:36234
is: HMDB00518
has only substance units: false
name: chenodeoxycholate
type: Species
boundary condition: false

metaM o2 e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
is: CHEBI:15379
is: C00007
name: O2
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: HMDB01377
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_cac42fe7_6354_487d_bfa4_9e2dae10a0cb
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:AI090874
name: _AI090874_1_c
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f8afe4ed_b5fc_4e48_b16d_9c76f4d28588
constant: false
type: Species
is: SBO:0000252
is: Q6ZMR3
has only substance units: false
initial concentration: NaN
name: LDHAL6A
initial amount: NaN
boundary condition: true
is encoded by: hsa:160287

http://identifiers.org/biomodels.db/MODEL1310110021#_74920d80_ae0a_4155_9d99_b26a3ddf6b3a
initial concentration: NaN
name: ALDH1A3
is: P47895
is: SBO:0000252
type: Species
is encoded by: hsa:220
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

metaR PI45PLC
is: SBO:0000176
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.4.11
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: false
modifier: MODEL1310110021#
fast: false

metaR RE3626M
kinetic law: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
reversible: false
product: MODEL1310110021#
reactant: MODEL1310110021#
name: RE3626

http://identifiers.org/biomodels.db/MODEL1310110021#_b687370f_db9f_49e3_940f_a2d56ac3f353
initial concentration: NaN
is: P27707
is: SBO:0000252
name: DCK
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1633

metaR GGH 10FTHF5GLUe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
reactant: MODEL1310110021#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110021#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_20e26ec8_8c24_435e_ba2f_3b00fa8eea11
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is: Q5JRA6
is encoded by: hsa:375056
name: MIA3
initial amount: NaN

metaR SRTNt6 2 r
kinetic law: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
reactant: MODEL1310110021#
type: Reaction

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_5a89cc2a_71ab_4ef7_a6f4_b745b37c90d9
initial concentration: NaN
type: Species
name: SDHD
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O14521
is encoded by: hsa:6392
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_cc8876cd_f9cc_4488_be08_c0c9cf0eba57
type: Species
constant: false
is: P61457
name: PCBD1
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5092

metaM 10fthf m
initial concentration: 1.0
name: 10-formyltetrahydrofolate(2-)
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00972
has only substance units: false
boundary condition: false

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_9a011620_b67e_484f_8cc6_6bd02874a5db
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80025
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: PANK2

metaR r0502
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.113
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
fast: false
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4

http://identifiers.org/biomodels.db/MODEL1310110021#_d51407eb_7e8a_4530_b0e3_25f5a8e1c8d2
is encoded by: hsa:6528
name: SLC5A5
initial concentration: NaN
is: Q92911
is: SBO:0000252
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN

metaR r2377
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1ed4793d_7db5_41fb_9d5f_07d22aeb9d6f
boundary condition: true
name: ALDH5A1
is encoded by: hsa:7915
constant: false
initial amount: NaN
is: Q546H9
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR FAOXC102m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_0fc6c93c_76e9_47cc_96b3_707472f968fb
is encoded by: hsa:4200
boundary condition: true
initial amount: NaN
is: P23368
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
name: ME2

metaM dadp c
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: dADP
boundary condition: false
is: HMDB01508
constant: false
is: C00206
type: Species
initial concentration: 1.0
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaR r0591
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reversible: true
modifier: MODEL1310110021#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
type: Reaction

metaM btn e
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
name: Biotin
is: HMDB00030
type: Species
constant: false
is: CHEBI:3420
is: C00120
initial concentration: 1.0
has only substance units: false

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaM ha e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
name: hyaluronan
is: CHEBI:16336
boundary condition: false
initial amount: NaN

metaM ump g
name: UMP(2-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00288
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
boundary condition: false
type: Species
has only substance units: false

metaR MERCPLACCYSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
reactant: MODEL1310110021#
reversible: false
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
fast: false
is: SBO:0000185

metaR PGI
name: glucose-6-phosphate isomerase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/5.3.1.9
is described by: ECO:0000134
product: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
reactant: MODEL1310110021#
reversible: true

metaM 3hbcoa m
constant: false
is: CHEBI:57316
initial concentration: 1.0
is: SBO:0000247
name: (S)-3-hydroxybutanoyl-CoA(4-)
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
boundary condition: false
is: HMDB01166
has only substance units: false
type: Species
initial amount: NaN

metaR r1620
is described by: ECO:0000000
reactant: MODEL1310110021#
fast: false
is: SBO:0000185
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_1bfe7978_0a83_40f6_a70e_045576c9422b
name: ADH5
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q6IRT1
initial amount: NaN
type: Species
is encoded by: hsa:128
initial concentration: NaN

metaM retn r
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:35291
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
name: all-trans-retinoate
constant: false

metaR r0726
is described by: ECO:0000000
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110021#

metaM ethamp r
is: HMDB00224
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:58190
name: O-phosphonatoethanaminium(1-)
initial amount: NaN
type: Species
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_0d5cd84c_b59c_4515_b9f0_b30da6957dd5
is: Q96CD2
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: PPCDC
initial concentration: NaN
is encoded by: hsa:60490
is: SBO:0000252

metaR r2376
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR DCMPDA
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.4.12
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
reversible: true
is: SBO:0000176
name: dCMP deaminase
is described by: ECO:0000254
modifier: MODEL1310110021#
fast: false
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_3da260e5_84be_43c2_be59_0e971762db62
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79837
is: B3KQV3
name: PIP4K2C
boundary condition: true
has only substance units: false
type: Species

metaR DAGt
is: SBO:0000185
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
name: diacylglycerol transport
is described by: ECO:0000269
kinetic law: MODEL1310110021#
type: Reaction
reversible: true

metaR NACHEXA4ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110021#
name: beta-N-acetylhexosaminidase A, lysosomal

metaR BTNPL
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: holocarboxylase synthestase (biotin protein ligase)
modifier: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10

http://identifiers.org/biomodels.db/MODEL1310110021#_27724fd5_b9de_4fc2_a95d_835aa325d0db
is encoded by: hsa:1606
initial concentration: NaN
is: P23743
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: DGKA

http://identifiers.org/biomodels.db/MODEL1310110021#_297580c1_b76d_4ae8_9a81_de7da0db5cb5
initial concentration: NaN
has only substance units: false
is encoded by: hsa:206358
name: SLC36A1
is: Q1LZ56
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false

metaR r0590
reactant: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is described by: ECO:0000000
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110021#
fast: false
reversible: false
product: MODEL1310110021#

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM prostge2 e
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:606564
has only substance units: false
is: HMDB01220
name: prostaglandin E2(1-)

http://identifiers.org/biomodels.db/MODEL1310110021#_d8e100c9_9231_4dc5_86e0_de7e36c5117e
is: SBO:0000252
constant: false
initial amount: NaN
name: ALPP
boundary condition: true
initial concentration: NaN
is encoded by: hsa:250
type: Species
has only substance units: false
is: P05187

http://identifiers.org/biomodels.db/MODEL1310110021#_f3311514_7eaf_4d73_9bad_f7a10483a587
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: O75752
boundary condition: true
name: B3GALNT1
is encoded by: hsa:8706
is: SBO:0000252
constant: false

metaR PGK
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.2.3
type: Reaction
name: phosphoglycerate kinase
is: SBO:0000176

metaM nadp m
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00217
is: SBO:0000247
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate

metaM hexdicoa x
is: HMDB02288
constant: false
initial concentration: 1.0
has only substance units: false
name: hexadecanedioylcoa
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r1591
is described by: ECO:0000000
reversible: true
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110021#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#

metaR RE1517M
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
is: SBO:0000176
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
type: Reaction
name: RE1517
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_6cb2c537_e91c_44ec_a3ae_d2083ef3abf3
constant: false
initial concentration: NaN
is: SBO:0000252
is: P49327
boundary condition: true
initial amount: NaN
name: FASN
type: Species
has only substance units: false
is encoded by: hsa:2194

http://identifiers.org/biomodels.db/MODEL1310110021#_5034993c_8905_4565_b8d3_08068a265291
boundary condition: true
type: Species
name: SDHB
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
is: P21912
is encoded by: hsa:6390

metaR r2032
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
is: SBO:0000185

metaR r2375
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_3d97537b_c225_4af6_be46_833f810e253c
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:159
has only substance units: false
type: Species
name: ADSS
constant: false
is: P30520

http://identifiers.org/biomodels.db/MODEL1310110021#_09ec8c33_d2e0_4561_a826_86106a9a508b
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:8526
name: DGKE
type: Species
is: A1L4Q0

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaM phaccoa c
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: phenylacetyl-CoA(4-)
is: CHEBI:57390
has only substance units: false
is: HMDB06503
initial concentration: 1.0
type: Species
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

metaR r1378
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
reversible: true
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_de5e8954_670f_401c_8e44_47b39e2c4922
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM lac L x
type: Species
is: HMDB00190
is: SBO:0000247
name: (S)-lactate
is: CHEBI:16651
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177

metaR DCSPTN1t
product: MODEL1310110021#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_577eb5a3_65c9_4a9b_8a99_5f5f7096f9f9
is encoded by: hsa:8574
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: O43488
type: Species
initial amount: NaN
constant: false
name: AKR7A2
has only substance units: false

metaR CYTD
name: cytidine deaminase
is described by: ECO:0000254
product: MODEL1310110021#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.4.5

metaM ump e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:57865
type: Species
name: UMP(2-)

metaM icit c
is: SBO:0000247
name: Isocitrate
is: C00311
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: HMDB00193
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:16087
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_b0e1e13d_cf73_453d_8145_b3ad630508e1
is encoded by: hsa:3988
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: P38571
boundary condition: true
initial concentration: NaN
name: LIPA

metaR r1590
is: SBO:0000185
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000000
fast: false

metaR r0728
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110021#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_ec0d7bdb_67ea_409e_801b_88df891bf602
has only substance units: false
is: Q8N4Q0
constant: false
initial amount: NaN
name: ZADH2
initial concentration: NaN
type: Species
is encoded by: hsa:284273
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_0a2d962a_6166_49cf_a952_efce73cfef80
is: Q5SPY7
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:954
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: ENTPD2

metaR biomass reaction
product: MODEL1310110021#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reversible: false
is: SBO:0000185
name: Generic human biomass reaction
fast: false

metaR r0443
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110021#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110021#

metaM k c
is: HMDB00586
initial concentration: 1.0
name: potassium
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
is: C00238
is: CHEBI:29103
type: Species
has only substance units: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238

http://identifiers.org/biomodels.db/MODEL1310110021#_f2b5878d_e497_47c7_b549_2afabb8a8511
is: Q16795
is encoded by: hsa:4704
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: NDUFA9
type: Species
initial concentration: NaN

metaR r2374
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110021#
type: Reaction
reversible: true
reactant: MODEL1310110021#
fast: false

metaM cs c l
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB02183
is: CHEBI:36005
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C45H67N2O46S3 CHARGE: -5

metaR r2031
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110021#
fast: false
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_eb9c06cb_37b1_472f_88e2_0911e19d936d
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:5052
name: PRDX1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_512cc38f_cb40_423f_a4a0_52e47f568156
constant: false
initial concentration: NaN
name: PIP5K1B
boundary condition: true
is: O14986
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:8395
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_20898fa9_fc75_4c39_baab_2fdc8c58dbd8
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:AI656480
is: SBO:0000252
name: _AI656480_1_m

http://identifiers.org/biomodels.db/MODEL1310110021#_618f7994_2dbd_4be2_8746_cb51c15d60e6
is: Q6LEN5
type: Species
name: CHAT
constant: false
is: SBO:0000252
is encoded by: hsa:1103
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR PHYTt
reactant: MODEL1310110021#
product: MODEL1310110021#
name: fatty acid transport via diffusion
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000

metaR r1019
is: SBO:0000185
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
fast: false
type: Reaction

metaR CYTK11n
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110021#
product: MODEL1310110021#
name: cytidylate kinase (dCMP,dGTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110021#_151ed1b4_96ad_4c4d_a552_c913507bd6c1
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC25A1
is: SBO:0000252
has only substance units: false
is: D9HTE9
boundary condition: true
constant: false
is encoded by: hsa:6576

http://identifiers.org/biomodels.db/MODEL1310110021#_05541e09_bb1e_4c4a_a958_b34216428203
boundary condition: true
is: P15531
constant: false
is encoded by: hsa:4830
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: NME1

http://identifiers.org/biomodels.db/MODEL1310110021#_673983fe_1033_4db3_b68c_7a677795f032
boundary condition: true
is: SBO:0000252
name: SLC4A10
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:57282
is: B7Z1R0
type: Species
has only substance units: false

metaR RE1826C
is: SBO:0000176
name: RE1826
reversible: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
kinetic law: MODEL1310110021#
fast: false
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_8e4cd554_57a4_433b_8275_e30590a9fce4
has only substance units: false
type: Species
is: SBO:0000252
name: SLC27A1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:376497
constant: false

metaM retn e
initial concentration: 1.0
boundary condition: false
name: all-trans-retinoate
is: HMDB01852
has only substance units: false
is: CHEBI:35291
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247
type: Species
constant: false

metaR CITtam
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is: SBO:0000185
name: citrate transport, mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
type: Reaction

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR r1623
modifier: MODEL1310110021#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000185

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR NTD1m
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.3.5
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
modifier: MODEL1310110021#
name: 5'-nucleotidase (dUMP),mitochondrial
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110021#

metaM akg e
is: HMDB00208
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16810
constant: false
name: 2-oxoglutarate(2-)
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
boundary condition: false
type: Species

metaR r2368
name: Organic anion transporter 5 Utilized transport
reversible: true
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000185
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR MMTSADm
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
reversible: false

metaM 2mpdhl m
boundary condition: false
is: SBO:0000247
is: CHEBI:17577
name: S-(2-Methylpropanoyl)-dihydrolipoamide
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
has only substance units: false

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_cabf5ab4_b3c3_473a_9e50_6e7e1e1cd6db
name: _728637_1_c
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:728637
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_d5f3b631_845f_416d_8525_45864ba49eac
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC24A3
is encoded by: hsa:57419
type: Species
is: Q9HC58

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR TRPHYDRO2
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
type: Reaction
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.14.16.4
is: SBO:0000176
product: MODEL1310110021#
is described by: ECO:0000269
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
fast: false
reversible: false

metaM ha deg1 l
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: hyaluronan degradation product 1
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C22H33N2O16 CHARGE: -1
constant: false
is: CHEBI:16336

metaR HPCLx
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000269
reversible: false
fast: false
notes: GENE_ASSOCIATION: (26062.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:10468558 NOTES:pristanal is the fatty aldehyde analog of pristanic acid Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. NJ
name: 2-hydroxyphytanoyl-CoA lyase
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176

metaM phyt x
initial concentration: 1.0
is: HMDB00801
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
name: phytanate
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:37257

metaR P4503A5
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1577.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107 NOTES:_8,9 epoxidation of aflatoxin assumed to take place on outer membrane NJ
name: cytochrome P450 3A5
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.14.14.1
is described by: ECO:0000269
reactant: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#

metaM CE5236 n
is: CHEBI:28002
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
has only substance units: false
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

metaR r1381
kinetic law: MODEL1310110021#
reversible: true
is: SBO:0000176
reactant: MODEL1310110021#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
product: MODEL1310110021#
type: Reaction

metaM accoa x
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
is: C00024
constant: false
is: CHEBI:57288
has only substance units: false
name: Acetyl-CoA
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01206

metaM apoC Lys c
initial concentration: 1.0
name: Apocarboxylase (Lys residue)
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
type: Species
constant: false
is: CHEBI:32551
has only substance units: false
is: SBO:0000247
is: HMDB00182

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

metaM lnlncg c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
type: Species
is: CHEBI:32391
is: HMDB03073

metaR r1580
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#

metaM HC02187 c
has only substance units: false
name: reverse-triiodthyronine
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_903441d3_24c7_483a_87a9_e210bb1bcbf1
is encoded by: hsa:34
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: ACADM
is: P11310
constant: false
is: SBO:0000252
has only substance units: false

metaR r1624
kinetic law: MODEL1310110021#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#

metaR Htx
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
name: H transporter, peroxisome
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR URIt5le
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110021#
fast: false
is: SBO:0000185
name: uridine transport in via sodium symport (1:2)
reactant: MODEL1310110021#
is described by: ECO:0000134
reversible: false
product: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_a42c3dcd_b7b5_4d68_9ff7_24f36a2ad831
is encoded by: hsa:10797
is: P13995
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: MTHFD2
constant: false
initial concentration: NaN
type: Species

metaR CMPACNAtg
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110021#
name: CMP-Sia Golgi transport via CMP antiport
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
type: Reaction
reversible: true
modifier: MODEL1310110021#
is described by: ECO:0000269

metaR CYSGLYexR
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
name: L-cysteine/glycine reversible exchanger
modifier: MODEL1310110021#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false

metaM glyald m
is: SBO:0000247
type: Species
is: HMDB01051
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
name: D-glyceraldehyde
is: CHEBI:17378

http://identifiers.org/biomodels.db/MODEL1310110021#_88717651_8b94_4679_a84d_f7bc5f4da46b
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: _R39999_1_c
type: Species
is encoded by: hsa:R39999
initial amount: NaN

metaR r1380
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
fast: false
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110021#

metaM acnacngalgbside hs e
initial concentration: 1.0
is: CHEBI:3338
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial amount: NaN
has only substance units: false
name: disialyl galactosylgloboside
type: Species
boundary condition: false
is: C00036
is: HMDB00223
is: SBO:0000247
constant: false

metaR r0954
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000185
name: MCT 1 Transport reaction
type: Reaction

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaR PFK
modifier: MODEL1310110021#
name: phosphofructokinase
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.11
type: Reaction
is described by: ECO:0000304
product: MODEL1310110021#
is: SBO:0000176
fast: false

metaR r1581
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#

metaM HC00342 m
initial amount: NaN
name: cis-aconitate(3-)
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: SBO:0000247
is: CHEBI:16383
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

metaM ach e
is: HMDB00895
initial concentration: 1.0
name: acetylcholine
is: CHEBI:15355
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaM akg c
has only substance units: false
is: HMDB00208
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16810
constant: false
boundary condition: false
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
name: 2-Oxoglutarate
type: Species

metaR r0013
is described by: ECO:0000000
product: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110021#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
reactant: MODEL1310110021#
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110021#_1d13cc21_5f22_42bf_8e47_06dfb030f4ba
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:279
is: P04746
name: AMY2A
is: SBO:0000252

metaM 10fthf e
is: HMDB00972
is: SBO:0000247
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
initial amount: NaN
name: 10-formyltetrahydrofolate(2-)
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false

metaM retn c
type: Species
boundary condition: false
constant: false
has only substance units: false
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
is: CHEBI:35291
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM HC02187 e
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
boundary condition: false
is: CHEBI:28774
initial concentration: 1.0
name: reverse-triiodthyronine
initial amount: NaN

metaR r1621
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110021#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
type: Reaction

metaR CSNAT2x
fast: false
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
type: Reaction
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.7
reversible: true
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.137
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR PTRCOX1
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110021#
name: Putrescine:oxygen oxidoreductase (deaminating)
is: SBO:0000176
is described by: ECO:0000304
reversible: false
modifier: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB

metaR r2366
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_d6896b27_1f9b_4063_aa01_76737b39bca5
is: SBO:0000252
is encoded by: hsa:AU149534
name: _AU149534_1_e
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM 4abut e
is: C00334
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
name: 4-Aminobutanoate
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:3628

metaM o2 m
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:15379
is: HMDB01377
initial concentration: 1.0
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
name: O2
is: C00007

http://identifiers.org/biomodels.db/MODEL1310110021#_cb0c8aec_688e_4934_889e_ad7a5b402183
is: E2QC23
is: SBO:0000252
is encoded by: hsa:23464
name: GCAT
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_cf5d2911_3e30_4b60_8f8b_0c480911585b
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AI684467
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: _AI684467_1_m

metaR ADSL2
fast: false
modifier: MODEL1310110021#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
name: adenylosuccinate lyase
is version of: http://identifiers.org/ec-code/4.3.2.2
reactant: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaM tetdecdicoa m
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB02288
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
has only substance units: false
name: 5,8-tetradecadienoylcoa
type: Species
initial amount: NaN

metaR PSt3
is: SBO:0000185
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110021#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
name: phosphatidylserine transport
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaM lnlncg e
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
is: SBO:0000247
has only substance units: false
name: gamma-linolenate
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_3131f399_0c92_459f_ba7d_07ea88e08c8c
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: HAO2
initial concentration: NaN
is encoded by: hsa:51179

metaR r1622
product: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#

metaR SUCOAS1m
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
modifier: MODEL1310110021#
type: Reaction
name: Succinate--CoA ligase (GDP-forming)
is: SBO:0000176
is described by: ECO:0000000
reversible: true

metaM adprib e
name: D-ribofuranos-5-yl-ADP(2-)
notes: FORMULA: C15H21N5O14P2 CHARGE: -2 INCHI: InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(23)8(21)5(32-14)1-30-35(26,27)34-36(28,29)31-2-6-9(22)11(24)15(25)33-6/h3-6,8-11,14-15,21-25H,1-2H2,(H,26,27)(H,28,29)(H2,16,17,18)/p-2/t5-,6-,8-,9-,10-,11-,14-,15?/m1/s1 EHMN_ABBREVIATION: C00301
is: CHEBI:57967
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01178

metaR EX dmhptcrn LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2,6 dimethylheptanoyl carnitine exchange
type: Reaction

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaM acnacngalgbside hs c
initial concentration: 1.0
is: HMDB00223
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
name: disialyl galactosylgloboside
is: CHEBI:3338
initial amount: NaN
boundary condition: false
type: Species
is: C00036

metaR RE0512M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110021#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
reversible: true
name: RE0512
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaM CE5132 c
is: CHEBI:57923
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: SBO:0000247
type: Species

metaM cmp g
name: CMP(2-)
type: Species
constant: false
is: HMDB00095
has only substance units: false
initial concentration: 1.0
is: CHEBI:60377
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_228578a4_7786_4f2f_bb59_8cf08f94de2b
is encoded by: hsa:6319
constant: false
is: SBO:0000252
initial concentration: NaN
name: SCD
type: Species
has only substance units: false
boundary condition: true
is: O00767
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_fb021d5a_148f_49a5_8aff_e44d34e912a1
initial concentration: NaN
is: Q674R7
name: ATG9B
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:285973

metaR BILGLCURtr
product: MODEL1310110021#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110021#
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
reactant: MODEL1310110021#
reversible: true

metaR ADSL1
is: SBO:0000176
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
name: adenylosuccinate lyase
is version of: http://identifiers.org/ec-code/4.3.2.2
reversible: false
modifier: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_cfcd6ee9_6969_43ec_892d_2f1f9897ac53
is: SBO:0000252
is: Q9BY49
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:55825
initial amount: NaN
type: Species
name: PECR

metaR DHPR
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110021#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.1.34
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.6.99.7 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:
name: 6,7-dihydropteridine reductase
reactant: MODEL1310110021#
type: Reaction

metaR r1583
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_7b34b59e_703f_4186_a226_ab690163737b
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: AMPD2
is encoded by: hsa:271
is: SBO:0000252
is: E9PNG0

metaR r1627
reversible: true
is described by: ECO:0000000
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110021#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_75dd999e_e1af_4ebd_8e65_a3719e89c64a
is: SBO:0000252
constant: false
is encoded by: hsa:1892
initial amount: NaN
is: P30084
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: ECHS1

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM 10fthf c
is: C00234
name: 10-Formyltetrahydrofolate
boundary condition: false
has only substance units: false
is: HMDB00972
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: SBO:0000247
type: Species
is: CHEBI:57454
constant: false
initial amount: NaN

metaR DHORD9
fast: false
is described by: ECO:0000269
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.5.2
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
reversible: false
name: dihydoorotic acid dehydrogenase (quinone10)
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )

metaR INSTt2r
product: MODEL1310110021#
name: inositol transport in via proton symport
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
modifier: MODEL1310110021#
fast: false

metaR r0236
is: SBO:0000176
product: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000000
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reversible: true
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false

metaM Sfglutth c
initial amount: NaN
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
has only substance units: false
is: SBO:0000247
name: S-formylglutathionate(1-)
is: CHEBI:57688
is: HMDB01550
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_5f846bde_a9b9_44e9_86b0_903c4f4b471d
is: SBO:0000252
is: Q02338
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:622
name: BDH1

metaM q10h2 m
constant: false
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247
name: Ubiquinol-10
initial amount: NaN
type: Species
boundary condition: false
is: HMDB13111

metaR r1584
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000

metaR NADPHtru
fast: false
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reversible: false
name: NADPH transporter, endoplasmic reticulum
reactant: MODEL1310110021#

metaM adrncoa c
is: SBO:0000247
is: C16170
boundary condition: false
name: adrenyl coenzyme A
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_33098a5a_8213_4384_aea7_c1ebcb1020a4
is: SBO:0000252
initial concentration: NaN
name: SLC35A2
is: P78381
constant: false
initial amount: NaN
is encoded by: hsa:7355
type: Species
has only substance units: false
boundary condition: true

metaR r1628
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM thm c
is: HMDB00235
is: CHEBI:0
name: Thiamin
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H17N4OS CHARGE: 1
initial amount: NaN
constant: false
type: Species
is: C00378
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d609b4e3_8f4c_4aa4_bb2e_35a5b896ba43
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: AMPD2
boundary condition: true
is encoded by: hsa:271
initial amount: NaN
is: Q01433

metaR r0129
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: true

metaR RE1530M
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: RE1530
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.21
reversible: true
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110021#

metaR r1585
reversible: true
product: MODEL1310110021#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaM 3mldz c
constant: false
is: HMDB04181
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 1-methylimidazole-4-acetaldehyde
notes: FORMULA: C6H8N2O CHARGE: 0 INCHI: InChI=1S/C6H8N2O/c1-8-4-6(2-3-9)7-5-8/h3-5H,2H2,1H3 EHMN_ABBREVIATION: C05827
boundary condition: false
is: CHEBI:28104
type: Species
has only substance units: false

metaM cmp e
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:60377
is: HMDB00095
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
has only substance units: false
initial amount: NaN

metaM co2 e
is: C00011
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16526
boundary condition: false
has only substance units: false
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: CO2
initial amount: NaN

metaR r0340
reactant: MODEL1310110021#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
type: Reaction
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#

metaR CYTK5n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
fast: false
name: cytidylate kinase (CMP),nuclear
reactant: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaR r1384
type: Reaction
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Guanosine aminohydrolase EC:3.5.4.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_19f5d37f_ef0c_48f5_8eba_4d2915e76bd4
is encoded by: hsa:3030
has only substance units: false
is: E9KL44
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: HADHA
type: Species
initial concentration: NaN
constant: false

metaR DM dsT antigen g
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_7dbce7e0_512e_48f3_85c8_9472f9a4345f
name: _AW277253_1_c
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AW277253
boundary condition: true
is: SBO:0000252
constant: false

metaM oaa m
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:16452
constant: false
name: Oxaloacetate
is: C00036
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: HMDB00223

http://identifiers.org/biomodels.db/MODEL1310110021#_d0d8d02d_b79d_44f7_9461_c5df15aeb1b8
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:80339
initial concentration: NaN
is: SBO:0000252
is: Q9NST1
boundary condition: true
type: Species
name: PNPLA3

metaR r2027
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110021#
reversible: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_ad06bc65_c281_470b_95fa_4e990bd48e95
initial concentration: NaN
has only substance units: false
type: Species
is: Q9UIG8
boundary condition: true
is encoded by: hsa:28232
is: SBO:0000252
name: SLCO3A1
constant: false
initial amount: NaN

metaR MAN1PT2
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.7.13
notes: GENE_ASSOCIATION: (29926.2) or (29926.1) or (29925.2) or (29925.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.22 Confidence Level: 0 AUTHORS: NOTES:JLR
reversible: false
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110021#
fast: false
name: mannose-1-phosphate guanylyltransferase (GDP)
reactant: MODEL1310110021#

metaR CHOLATEt
modifier: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
name: cholate transport via bicarbonate countertransport
type: Reaction
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
fast: false
is described by: ECO:0000269
reactant: MODEL1310110021#

metaR r1586
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
type: Reaction

metaR r1625
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110021#

metaM gdpmann c
type: Species
is: CHEBI:57527
initial concentration: 1.0
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01163
name: GDP-alpha-D-mannose(2-)
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c1a39147_6ffb_482d_9ad9_329aea4cc0f4
initial amount: NaN
initial concentration: NaN
name: NUDT12
type: Species
constant: false
is encoded by: hsa:83594
boundary condition: true
is: SBO:0000252
is: Q9BQG2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_e02b36aa_ac74_4f49_a61a_6103ca7e9c49
initial concentration: NaN
name: PIK3C2G
constant: false
is encoded by: hsa:5288
is: SBO:0000252
initial amount: NaN
is: O75747
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_9ffbaab1_3cb7_40b4_b454_5e0b24fef41a
is encoded by: hsa:4842
has only substance units: false
constant: false
is: B4DG68
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: NOS1

http://identifiers.org/biomodels.db/MODEL1310110021#_f5976f99_d3ee_4bb7_9ce8_4d3c6608efcf
is: P19623
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6723
initial concentration: NaN
name: SRM
initial amount: NaN
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_5c8f5c8e_8dd5_438e_9994_c2f130771564
is: SBO:0000252
initial concentration: NaN
is: P49753
type: Species
is encoded by: hsa:10965
has only substance units: false
boundary condition: true
name: ACOT2
initial amount: NaN
constant: false

metaM btcoa c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57371
is: HMDB01088
initial amount: NaN
type: Species
is: C00136
constant: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
boundary condition: false
name: Butanoyl-CoA

metaM HC01842 c
initial amount: NaN
constant: false
name: Phosphodimethylethanolamine
is: SBO:0000247
is: CHEBI:31997
boundary condition: false
has only substance units: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
type: Species
initial concentration: 1.0

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_0c1776cb_7bdf_4983_95f5_090202f05756
initial concentration: NaN
is: SBO:0000252
is: P49902
is encoded by: hsa:22978
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
name: NT5C2
constant: false

metaR RE1845C
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
reactant: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110021#
name: RE1845
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110021#
type: Reaction

metaR r1626
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#

metaR GLUt7l
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110021#
reversible: false
fast: false
product: MODEL1310110021#
name: Glutamate transport, lysosomal

metaR r1587
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#

metaM dadp m
name: dADP(3-)
constant: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
initial concentration: 1.0
is: CHEBI:57667
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01508

http://identifiers.org/biomodels.db/MODEL1310110021#_58dca5d9_bbd7_4adb_baff_33a9b2ca7622
boundary condition: true
name: MDH2
initial amount: NaN
type: Species
is: P40926
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4191

metaM 6pgl r
initial amount: NaN
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
constant: false
is: HMDB01127
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:57955

http://identifiers.org/biomodels.db/MODEL1310110021#_ae245f1e_6c7f_4a13_97cb_a99857158741
has only substance units: false
constant: false
is: SBO:0000252
is: P43353
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: ALDH3B1
is encoded by: hsa:221
type: Species

metaM co2 c
is: HMDB01967
initial concentration: 1.0
is: C00011
initial amount: NaN
type: Species
constant: false
is: CHEBI:3313
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0
name: CO2

metaM cmp c
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00055
constant: false
is: CHEBI:60377
is: SBO:0000247
is: HMDB00095
has only substance units: false
boundary condition: false
name: CMP
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

http://identifiers.org/biomodels.db/MODEL1310110021#_7c49880c_0aed_457c_b17d_6d67d4cf239f
initial concentration: NaN
constant: false
is: Q86VV3
type: Species
name: ENTPD1
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:953
has only substance units: false

metaR GLUPRT
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.14
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
modifier: MODEL1310110021#
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
name: glutamine phosphoribosyldiphosphate amidotransferase
reactant: MODEL1310110021#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1ee430ba_69c7_4c7f_ad98_fdfe923500a2
is: Q15067
is encoded by: hsa:51
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ACOX1
constant: false
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_f7b593aa_aea9_40c8_8275_ce787fa8f930
type: Species
constant: false
is encoded by: hsa:AI024818
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _AI024818_1_c
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d95c0ed0_a51e_4a89_95e8_bf0e4d4e2a35
constant: false
boundary condition: true
initial concentration: NaN
name: MLYCD
has only substance units: false
type: Species
is encoded by: hsa:23417
is: O95822
initial amount: NaN
is: SBO:0000252

metaR CHOLPtg
name: choline phosphate intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_d618b376_9e90_49eb_9df3_60f5b0356e32
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:LOC727762
name: _LOC727762_1_m
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM ach n
is: SBO:0000247
boundary condition: false
name: acetylcholine
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:15355

http://identifiers.org/biomodels.db/MODEL1310110021#_1cf9afb9_ce1a_4973_b86c_00c874cbf96a
is: SBO:0000252
name: RDH16
has only substance units: false
constant: false
type: Species
is encoded by: hsa:8608
is: O75452
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR DESAT18 3
type: Reaction
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110021#
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
fast: false
product: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: false
reactant: MODEL1310110021#

metaR RDH2
reversible: true
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
is described by: ECO:0000269
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: retinol dehydrogenase (9-cis,NADH)
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.315
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_22ad20e2_895d_4e32_b439_c2c0f9bd10ee
is encoded by: hsa:80347
is: SBO:0000252
initial concentration: NaN
name: COASY
boundary condition: true
constant: false
has only substance units: false
is: Q13057
initial amount: NaN
type: Species

metaR LCADi
reversible: false
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
name: lactaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_8cc72eba_eded_4661_85c4_4edf9e08d35c
is: SBO:0000252
initial amount: NaN
name: SYNJ1
is encoded by: hsa:8867
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: C9JFZ1

metaM dadp n
is: HMDB01508
type: Species
name: dADP(3-)
constant: false
is: SBO:0000247
is: CHEBI:57667
boundary condition: false
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR DMHPTCRNte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110021#
name: 2,6 dimethylheptanoyl carnitine transport

metaR r0345
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
type: Reaction
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true

metaM gum e
is: SBO:0000247
notes: FORMULA: C2760000H5060000O2530000 CHARGE: 0
initial amount: NaN
name: gums
initial concentration: 1.0
has only substance units: false
is: HMDB00725
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_a7fbda41_eca0_4c13_b40f_603662b6f4a4
boundary condition: true
is encoded by: hsa:7108
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: O76062
is: SBO:0000252
initial concentration: NaN
name: TM7SF2

metaR r1588
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR r1736
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
reversible: false
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

metaM 5oxpro e
boundary condition: false
has only substance units: false
is: CHEBI:57606
constant: false
is: SBO:0000247
name: 5-oxoprolinate
initial amount: NaN
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: HMDB00267
initial concentration: 1.0

metaR GGH 7DHFe
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false
type: Reaction
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is: SBO:0000176
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR PGMT
name: phosphoglucomutase
is version of: http://identifiers.org/ec-code/5.4.2.2
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.4.2.2 Confidence Level: 0 AUTHORS: PMID:4829444 NOTES:
kinetic law: MODEL1310110021#
is: SBO:0000176
fast: false
is described by: ECO:0000134

metaM 3hmp m
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
type: Species
constant: false
boundary condition: false
is: CHEBI:11805
is: HMDB00023
name: 3-hydroxy-2-methylpropanoate

metaR SERDGLNexR
reversible: true
name: D-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000304
type: Reaction
fast: false
product: MODEL1310110021#

metaR OCCOAtm
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Octanoyl-CoA transport, diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_796218b2_db7a_484a_a6e6_276c5873ce02
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3632
initial amount: NaN
is: Q14642
name: INPP5A
is: SBO:0000252
type: Species

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR ORNDC
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110021#
name: Ornithine Decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.17
modifier: MODEL1310110021#
product: MODEL1310110021#

metaM lgt S c
has only substance units: false
initial amount: NaN
is: CHEBI:57474
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01066
type: Species
name: (R)-S-lactoylglutathionate(1-)
boundary condition: false

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR RDH1
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
reactant: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
name: retinol dehydrogenase (all-trans)

metaM aicar c
boundary condition: false
initial concentration: 1.0
type: Species
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: C04677
constant: false
is: SBO:0000247
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: CHEBI:58475
is: HMDB01517
initial amount: NaN
has only substance units: false

metaR r0801
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
reversible: true
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
type: Reaction
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR ASNtN1
name: Asparagine transport (Na, H coupled)
is: SBO:0000185
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

http://identifiers.org/biomodels.db/MODEL1310110021#_e51b1cff_c768_42a0_a817_8b2d2462a145
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:7086
is: SBO:0000252
has only substance units: false
name: TKT
initial concentration: NaN
is: E7EPA7

metaM taur x
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
is: HMDB00251
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: taurine
is: SBO:0000247
is: CHEBI:15891
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_f852688f_56fb_4494_9477_0ec249b0fabf
has only substance units: false
type: Species
initial amount: NaN
name: NDUFA10
is: SBO:0000252
is encoded by: hsa:4705
constant: false
boundary condition: true
is: O95299
initial concentration: NaN

metaM accoa n
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57288
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
boundary condition: false
name: acetyl-CoA(4-)
is: HMDB01206
has only substance units: false

metaR 5ADTSTSTERONESte
type: Reaction
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is described by: ECO:0000000
is: SBO:0000185
name: sulfonated testosterone transport
reversible: true
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_24aca820_c0b8_4b0b_8648_ed5a0a0a3b87
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10587
is: Q9NNW7
name: TXNRD2

metaM xyl D l
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:15936
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
type: Species
name: aldehydo-D-xylose
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_b9590c2e_eb71_4219_a554_f47f79f0bb2b
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5295
has only substance units: false
boundary condition: true
is: B3KT19
name: PIK3R1
type: Species
constant: false
initial amount: NaN

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f1da5df0_3c91_4513_914c_c1a9ad4eaf26
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9UHI5
is encoded by: hsa:23428
name: SLC7A8

http://identifiers.org/biomodels.db/MODEL1310110021#_b094f5c1_f87a_463c_849b_7dc79c40174f
has only substance units: false
type: Species
is encoded by: hsa:3939
initial amount: NaN
is: SBO:0000252
name: LDHA
initial concentration: NaN
is: P00338
boundary condition: true
constant: false

metaR ADKd
reversible: true
product: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase (d form)
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110021#_44b73c24_75f0_4cb2_9b32_92286458857e
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:158
initial amount: NaN
is: SBO:0000252
name: ADSL

metaR MAGt
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000269
reversible: true
name: monoacylglycerol 2 transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_511b5b87_46ff_42c5_a725_5acff3525cb4
boundary condition: true
is encoded by: hsa:5287
initial amount: NaN
name: PIK3C2B
initial concentration: NaN
is: O00750
constant: false
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_5c96e09b_4398_47a1_973e_bf161e729e7f
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:443
type: Species
name: ASPA
initial concentration: NaN
is: Q6FH48
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_8a5a82e4_cf1a_47fb_bd42_367ee2b25a14
constant: false
has only substance units: false
is encoded by: hsa:728441
initial concentration: NaN
boundary condition: true
name: GGT2
initial amount: NaN
type: Species
is: SBO:0000252

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaR DTTPtn
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
fast: false
name: dTTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110021#

metaR PROSTGE2t
modifier: MODEL1310110021#
reversible: true
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110021#

metaR DCSPTN1COAtx
reversible: true
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
name: fatty acid intracellular transport
type: Reaction
fast: false

metaM 5oxpro c
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
name: 5-oxoprolinate
constant: false
is: SBO:0000247
is: CHEBI:57606
type: Species
boundary condition: false
has only substance units: false
is: HMDB00267
initial concentration: 1.0
initial amount: NaN

metaR RE3568C
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110021#
name: RE3568
is: SBO:0000176
fast: false

metaR TTDCAFATPc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaM 2decdicoa m
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
name: 2,7-decadienoylcoa

metaR r0881
name: Active transport
reversible: false
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
is: SBO:0000185

metaM ethamp c
is: SBO:0000247
name: ethamp[c]
initial concentration: 1.0
constant: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
has only substance units: false
is: HMDB00224
type: Species
boundary condition: false
is: CHEBI:58190
initial amount: NaN

metaR r1629
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_b4faaa97_eec5_40fd_b668_3ca2506adefb
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:T83654
type: Species
name: _T83654_1_e
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_8d449658_a076_41c3_a26b_90b0ce034881
has only substance units: false
boundary condition: true
name: SLCO1B1
is encoded by: hsa:10599
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: Q9Y6L6
is: SBO:0000252

metaM fpram c
boundary condition: false
has only substance units: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
type: Species
is: C04640
constant: false
is: CHEBI:58478
is: SBO:0000247
initial concentration: 1.0
is: HMDB06211
initial amount: NaN

metaM asp L c
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
name: L-aspartate(1-)
has only substance units: false
is: SBO:0000247
is: HMDB00191
is: CHEBI:29991
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_e42782c7_dfc7_4b6f_8e77_5cabf19fee1f
name: CPT1C
is encoded by: hsa:126129
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q8TCG5
constant: false
initial concentration: NaN
type: Species
initial amount: NaN

metaM HC00342 c
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: CHEBI:16383
name: cis-aconitate(3-)
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_8b1be49c_4bfc_48f3_a137_749e2f0a5a9c
is encoded by: hsa:6565
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q16348
has only substance units: false
boundary condition: true
name: SLC15A2
constant: false

metaR r1020
fast: false
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_937367d9_e373_4d66_a24e_189cc6bae036
boundary condition: true
is: P00374
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: DHFR
is: SBO:0000252
is encoded by: hsa:1719
constant: false
type: Species

metaR PEt
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
kinetic law: MODEL1310110021#
name: phosphatidylethanolamine transport
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM 4mzym int1 r
is: HMDB06927
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 4-Methylzymosterol intermediate 1
type: Species

metaM lac L c
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: (S)-lactate
constant: false
is: HMDB00190
initial amount: NaN

metaR RE1530C
is described by: ECO:0000000
is: SBO:0000176
name: RE1530
type: Reaction
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
product: MODEL1310110021#
reversible: true

metaM maltttr e
is: HMDB01296
is: SBO:0000247
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5141
boundary condition: false
is: C02052
constant: false
has only substance units: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
initial amount: NaN
name: Maltotetraose

metaR RDH3
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: retinol dehydrogenase (11-cis,NADH)
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true

metaM alpam m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: SBO:0000247
name: S-aminomethyldihydrolipoamide
boundary condition: false
type: Species
is: HMDB06239
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c72fcb65_ebbf_4755_af80_8a891dd94dbe
is: Q16718
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4698
initial amount: NaN
name: NDUFA5
initial concentration: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_4c9a9938_00ba_4b94_87d5_71d9ea33d600
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:8396
name: PIP4K2B
initial amount: NaN
type: Species
has only substance units: false
is: P78356

http://identifiers.org/biomodels.db/MODEL1310110021#_1108205e_0013_4b27_8138_ab37ad936af5
type: Species
has only substance units: false
name: _D29675_1_c
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:D29675
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_e8db4c84_97b0_4ada_9154_e438cd63bda0
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:92483
is: SBO:0000252
is: Q9BYZ2
type: Species
initial amount: NaN
name: LDHAL6B
constant: false

metaM C02528 r
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: SBO:0000247
initial concentration: 1.0
is: HMDB00518
name: chenodeoxycholate
has only substance units: false
type: Species
constant: false
is: CHEBI:36234
boundary condition: false

metaR ABTD
name: L-arabinitol 4-dehydrogenase
kinetic law: MODEL1310110021#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110021#
fast: false
reversible: true
reactant: MODEL1310110021#

metaM HC01401 m
constant: false
is: CHEBI:27668
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
type: Species
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
initial amount: NaN

metaR RE2759X
product: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/5.1.99.4
modifier: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
name: RE2759
fast: false

metaR ACETONEt2
reversible: true
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000185
name: acetone transport via proton symport
is described by: ECO:0000269
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD

metaR RE3243R
name: RE3243
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110021#

metaR ACOAD1fm
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110021#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM adn e
initial concentration: 1.0
is: CHEBI:16335
has only substance units: false
constant: false
is: HMDB00050
initial amount: NaN
boundary condition: false
is: C00212
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
type: Species
name: Adenosine

metaR LPS2e
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.1.3
kinetic law: MODEL1310110021#
reversible: false
name: lipase, extracellular
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
product: MODEL1310110021#

metaR GUAt
name: Guanine transport
reactant: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000185
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reversible: true

metaR THMMPtm
name: Thiamine monophosphate transport, mitochondrial
reversible: true
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM 4abut c
type: Species
constant: false
is: C00334
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: CHEBI:3628
name: 4-Aminobutanoate
is: HMDB00112
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_c299ff3e_c728_4f56_9398_d82983b8b1da
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: _AI440329_1_r
has only substance units: false
is encoded by: hsa:AI440329
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_0b4e79a6_47aa_442d_b229_f8a324905ef5
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1718
name: DHCR24
is: SBO:0000252
is: Q15392
constant: false

metaR PROSTGI2t
kinetic law: MODEL1310110021#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
name: Prostaglandin I2 transport
product: MODEL1310110021#
is described by: ECO:0000269
reactant: MODEL1310110021#
reversible: true

metaR FALDH
reversible: true
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110021#
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: formaldehyde dehydrogenase
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reactant: MODEL1310110021#

metaR RE1527M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
fast: false
is: SBO:0000176
name: RE1527
is version of: http://identifiers.org/ec-code/4.2.1.107

http://identifiers.org/biomodels.db/MODEL1310110021#_36a44a51_e971_4771_bcce_0dc24f8fb05b
constant: false
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: PC
is encoded by: hsa:5091
is: P11498
initial amount: NaN
has only substance units: false

metaM asp L e
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:29991
constant: false
is: HMDB00191
name: L-aspartate(1-)
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR FATP6t
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#
name: fatty acid electroneutral transport
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7
type: Reaction

metaR ACACt2m
name: Acetoacetate mitochondrial transport via H+ symport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
reversible: true
fast: false

metaR r0655
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
type: Reaction
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.2

metaM CE5786 e
boundary condition: false
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
name: kinetensin
type: Species
constant: false
is: CHEBI:27485
is: HMDB02710
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM lac L e
name: (S)-lactate
has only substance units: false
boundary condition: false
constant: false
type: Species
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00190

http://identifiers.org/biomodels.db/MODEL1310110021#_2512c0e8_77df_42ed_9056_d973b13818d0
is encoded by: hsa:8876
constant: false
is: SBO:0000297
is encoded by: hsa:8875
has part: A8K7W0
initial concentration: NaN
name: VNN3:VNN2:VNN1
has part: O95497
has only substance units: false
boundary condition: true
is encoded by: hsa:55350
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_a8b640da_8899_4642_8596_3c395ed50b92
constant: false
is: A8K0I1
is: SBO:0000252
type: Species
initial amount: NaN
name: DGKH
boundary condition: true
is encoded by: hsa:160851
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_57f78715_89ac_4635_b72a_1a7409526eef
constant: false
is: P00568
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:203
name: AK1
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_b56ecc3e_3733_4d83_8f4c_281153224b33
has only substance units: false
constant: false
is: Q6ZWP6
name: ACAD8
type: Species
is: SBO:0000252
is encoded by: hsa:27034
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM hco3 c
is: HMDB00595
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
type: Species
is: C00288
name: Bicarbonate
constant: false
is: CHEBI:17544
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM adn c
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
name: Adenosine
is: CHEBI:16335
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00050
constant: false
is: C00212

metaR CRVNCtr
type: Reaction
fast: false
name: fatty acid transport via diffusion
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
kinetic law: MODEL1310110021#

metaR RE3367E
name: RE3367
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_0c7822f6_f27f_44c2_ad52_80d95881f4a7
is: P55084
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
name: HADHB
is encoded by: hsa:3032
boundary condition: true
constant: false
is: SBO:0000252

metaR FAOXC142C122m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM psylchol e
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/94244
type: Species
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false
name: psillium-glycocholic acid complex
boundary condition: false
initial amount: NaN

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaM aflatoxin c
notes: FORMULA: C17H12O6 CHARGE: 0 INCHI: InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
constant: false
name: aflatoxin B1
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:2504
is: HMDB06552
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_0b5f7553_b79b_4d95_8dbe_8acd042b187b
is encoded by: hsa:2597
initial amount: NaN
is: E7EUT4
has only substance units: false
name: GAPDH
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252

metaM CE5161 r
boundary condition: false
initial concentration: 1.0
is: CHEBI:57923
constant: false
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_cc3fc34e_5231_4321_88ea_a23bd24176e2
name: PKM2
is encoded by: hsa:5315
initial amount: NaN
boundary condition: true
is: P14618
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

metaM trdox m
is: CHEBI:18191
name: Oxidized thioredoxin
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
constant: false

metaM oxa m
has only substance units: false
type: Species
name: oxalate(2-)
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:30623
is: HMDB02329

metaR ACOAD9m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is described by: ECO:0000269
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
type: Reaction
modifier: MODEL1310110021#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110021#_d262f5e8_4e0b_4515_9c21_450ea702e69e
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
name: PHPT1
is: Q9P019
type: Species
is encoded by: hsa:29085
initial amount: NaN
is: SBO:0000252

metaM etfrd m
is: SBO:0000247
type: Species
is: HMDB01356
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: RH2 CHARGE: 0
constant: false
has only substance units: false
boundary condition: false
name: Electron transfer flavoprotein reduced
is: CHEBI:57312

http://identifiers.org/biomodels.db/MODEL1310110021#_a07705e9_194a_4e92_811b_0cc2cb8e463a
constant: false
is: P13196
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ALAS1
is encoded by: hsa:211
type: Species
boundary condition: true

metaR CITRtm
is described by: ECO:0000269
type: Reaction
fast: false
product: MODEL1310110021#
is: SBO:0000185
name: citrulline mitochondrial transport via proton antiport
modifier: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaM accoa m
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00024
initial amount: NaN
constant: false
name: Acetyl-CoA
is: HMDB01206
type: Species

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_ffcc8076_9ece_4ff2_a548_42555c77f5f3
initial amount: NaN
is encoded by: hsa:259230
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: SGMS1
is: D3DWC4

http://identifiers.org/biomodels.db/MODEL1310110021#_f78070d1_b002_4271_a4ed_aeb6717d3a5f
initial amount: NaN
constant: false
name: TREH
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:11181
is: SBO:0000252
is: O43280

metaM o2 r
initial concentration: 1.0
has only substance units: false
is: C00007
constant: false
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
name: O2
initial amount: NaN
is: HMDB01377
boundary condition: false
is: SBO:0000247
is: CHEBI:15379

metaR r0653
is: SBO:0000176
product: MODEL1310110021#
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_10b27e05_65ed_482c_90ce_c0c58ddbabcd
is encoded by: hsa:8525
boundary condition: true
type: Species
has only substance units: false
name: DGKZ
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: B7Z2M9

metaM acnacngalgbside hs g
boundary condition: false
is: HMDB00223
has only substance units: false
is: C00036
type: Species
initial concentration: 1.0
name: disialyl galactosylgloboside
constant: false
initial amount: NaN
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: SBO:0000247
is: CHEBI:3338

metaM gmp c
boundary condition: false
name: GMP
is: CHEBI:58115
is: SBO:0000247
is: HMDB01397
type: Species
initial amount: NaN
is: C00144
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
constant: false
initial concentration: 1.0

metaR GUMTCHOLe
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Binding of guar gums with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM CE1939 e
initial concentration: 1.0
constant: false
initial amount: NaN
name: spermidine monoaldehyde 1
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-1-2-5-9-6-3-7-10/h7,9H,1-6,8H2/p+2 EHMN_ABBREVIATION: CE1939
type: Species
boundary condition: false
is: CHEBI:36781

http://identifiers.org/biomodels.db/MODEL1310110021#_20af4cb4_d37e_4752_af2d_792250d5f4e8
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
is: P00918
initial amount: NaN
is encoded by: hsa:760
name: CA2

metaR C204CRNt
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
product: MODEL1310110021#
is described by: ECO:0000000
name: arachidonic acid transport into the mitochondria
fast: false
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_6cc29b4f_e0f0_47db_9e5e_92105c005189
is: Q96PE3
constant: false
boundary condition: true
name: INPP4A
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3631

metaR Htr
product: MODEL1310110021#
type: Reaction
name: H transporter, endoplasmic reticulum
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR ACGALK
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
name: N-acetylgalactosamine kinase

metaM ppi c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: Diphosphate
is: CHEBI:0
type: Species
is: C00013
is: HMDB00250
constant: false
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110021#_c7e8e4bf_2fd2_4a59_b985_9fda72debd52
is: Q8WXF9
is: SBO:0000252
is encoded by: hsa:66035
type: Species
initial amount: NaN
name: SLC2A11
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false

metaM arachdcrn r
is: SBO:0000247
name: C20:4 carnitine
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57368
is: HMDB06523
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false

metaM pail hs n
constant: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: CHEBI:57880
type: Species
initial amount: NaN
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM bhb e
name: (R)-3-hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
is: CHEBI:10983
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

metaR r2198
reactant: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
type: Reaction
modifier: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
is described by: ECO:0000000

metaR RE2814M
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
kinetic law: MODEL1310110021#
name: RE2814

metaM Asn X Ser Thr l
notes: FORMULA: XH CHARGE: 0
is: C01342
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00051
name: protein-linked asparagine residue (N-glycosylation site)
boundary condition: false
type: Species
is: CHEBI:28938
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_dfbaa48b_64e2_469d_83db_133b571c3e7b
is: P00326
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:126
name: ADH1C
has only substance units: false
type: Species
boundary condition: true

metaR PPA
product: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
name: inorganic diphosphatase
kinetic law: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110021#

metaR MALSO3tm
product: MODEL1310110021#
name: Malate:sulfite antiport, mitochondrial
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
is: SBO:0000185
reversible: true
modifier: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
fast: false

metaM HC02210 e
initial amount: NaN
name: prostaglandin-d3
has only substance units: false
is: SBO:0000247
is: CHEBI:34939
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
type: Species
constant: false

metaM glc D r
name: D-glucose
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
type: Species
has only substance units: false
is: CHEBI:4167
initial concentration: 1.0
is: HMDB00122
constant: false
is: SBO:0000247

metaR r0604
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
reversible: false
is: SBO:0000176
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168

metaM 34dhmald m
is: HMDB06242
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
has only substance units: false
name: 3,4-Dihydroxymandelaldehyde
is: http://identifiers.org/pubchem.compound/7903
constant: false
is: C05577
initial amount: NaN
boundary condition: false

metaM CE4790 m
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
has only substance units: false

metaM retinal c
initial concentration: 1.0
is: HMDB01358
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:15035
name: retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
constant: false
is: SBO:0000247
has only substance units: false

metaR GGH 6DHFl
reversible: false
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6DHF), lysosomal
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

http://identifiers.org/biomodels.db/MODEL1310110021#_3e37c234_e75f_47ca_9b66_ea42d2f79c11
is encoded by: hsa:6120
is: Q53TV9
has only substance units: false
name: RPE
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_6a50bed9_8060_4460_af46_407fff2ff3e9
is encoded by: hsa:115286
is: SBO:0000252
boundary condition: true
name: SLC25A26
type: Species
is: F8WAB8
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR r2105
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
fast: false

metaR GGH 5THFe
kinetic law: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (5THF), extracellular
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is version of: http://identifiers.org/ec-code/3.4.19.9
fast: false

metaR TDPm
reversible: false
name: thiamin pyrophosphatase, mitochondrial
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT

metaR r0603
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
fast: false
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.12
type: Reaction
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is: SBO:0000176
reversible: true
modifier: MODEL1310110021#
reactant: MODEL1310110021#

metaR AHEXASE2ly
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
reactant: MODEL1310110021#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110021#
reversible: false
product: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
modifier: MODEL1310110021#

metaR r2199
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
modifier: MODEL1310110021#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM anth c
is: CHEBI:16567
is: SBO:0000247
name: anthranilate
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial concentration: 1.0
initial amount: NaN
is: HMDB01123
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c979d823_f54d_4ee5_b55e_30a8f4f60f1b
is encoded by: hsa:3948
initial concentration: NaN
name: LDHC
boundary condition: true
type: Species
constant: false
has only substance units: false
is: P07864
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_5a239c6e_b049_4dd1_b296_50b2c3a81259
name: ATP2B3
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is: Q16720
initial amount: NaN
is encoded by: hsa:492

metaM 5dpmev x
is: CHEBI:15899
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
is: HMDB01090
type: Species
initial concentration: 1.0
name: (R)-5-Diphosphomevalonate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_8925da6d_3074_427a_b7c9_0803d69ea65c
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is: Q13907
type: Species
is encoded by: hsa:3422
name: IDI1

metaR PRISTCOAtcx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR MI134PP
name: inositol-1,3,4-trisphosphate 1-phosphatase
reactant: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.57
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c507d43c_fe4f_4dab_89e2_eaac20eded0a
type: Species
initial concentration: NaN
boundary condition: true
name: _AI694761_1_c
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI694761
has only substance units: false

metaR PTCRTD
fast: false
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
name: diffusion of putriscine into the endothelial cells
is described by: ECO:0000134

metaM prist x
boundary condition: false
has only substance units: false
is: CHEBI:51340
constant: false
type: Species
name: pristanic acid
initial amount: NaN
is: HMDB00795
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
initial concentration: 1.0
is: SBO:0000247

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM atp e
is: SBO:0000247
name: ATP(4-)
boundary condition: false
is: C00002
type: Species
is: HMDB00538
is: CHEBI:57299
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaR r2104
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110021#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR r0560
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
is described by: ECO:0000000
reversible: false

metaM CE5125 x
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
name: (2S)-pristanoyl-CoA
has only substance units: false
is: CHEBI:12947
is: SBO:0000247

metaM 25aics c
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:58443
type: Species
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00797
is: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

metaR r2196
modifier: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
reversible: true
is: SBO:0000185
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false

metaM ppi e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
type: Species
has only substance units: false
is: C00013
constant: false
is: HMDB00250
initial amount: NaN
is: CHEBI:33019

metaR DNDPt19m
name: dUDP transport via ATP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000269
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction

metaM ins c
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial amount: NaN
is: CHEBI:17596
is: SBO:0000247
name: Inosine
has only substance units: false
is: HMDB00195
type: Species
boundary condition: false
is: C00294
constant: false
initial concentration: 1.0

metaM odecoa c
initial concentration: 1.0
is: HMDB01322
is: SBO:0000247
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
name: Octadecenoyl-CoA (n-C18:1CoA)
boundary condition: false
is: CHEBI:3793
type: Species
initial amount: NaN
has only substance units: false

metaM acgam l
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
initial concentration: 1.0
is: HMDB00215
type: Species
name: N-acetyl-D-glucosamine
initial amount: NaN
is: CHEBI:17411
constant: false
is: SBO:0000247

metaM lnlncgcoa m
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
is: HMDB06368
has only substance units: false

metaM HC02210 c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
name: prostaglandin-d3
type: Species
is: CHEBI:34939
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_94184ad5_3a66_4e7f_9df3_6efdc188efd1
is: Q6LEN6
is encoded by: hsa:1103
name: CHAT
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_5459030a_c037_4613_bd40_0dbb81d08744
name: HSD3B1
is: P14060
type: Species
initial amount: NaN
is encoded by: hsa:3283
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

metaR PNTOte
reactant: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000134
name: Transport of (R)-Pantothenate
fast: false
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_2a740eea_3396_4c5c_affe_c104934fa1f7
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:D87002
name: _D87002_1_m
is: SBO:0000252
boundary condition: true
constant: false

metaR r2107
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110021#
reactant: MODEL1310110021#

metaR r0450
modifier: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
type: Reaction
fast: false
reversible: true
product: MODEL1310110021#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_2e6ebe26_f70b_49ae_b6ea_bbfaf84cfe7b
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AGPAT7
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: _AGPAT7_1_c
constant: false

metaR r0683
reversible: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110021#
fast: false
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000

metaM HC00319 c
has only substance units: false
name: Malonate
boundary condition: false
initial amount: NaN
is: CHEBI:30794
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
constant: false

metaR ARAB Lt
is described by: ECO:0000000
type: Reaction
fast: false
name: L-arabinoase extracellular transport
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
is: SBO:0000185
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_25782ae7_439a_496c_9d61_add6b70322d6
is encoded by: hsa:29880
has only substance units: false
is: SBO:0000252
is: Q9Y673
initial amount: NaN
type: Species
name: ALG5
constant: false
boundary condition: true
initial concentration: NaN

metaM anth e
is: CHEBI:16567
name: anthranilate
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01123
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
constant: false
is: SBO:0000247

metaR PItn
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110021#
name: phosphate transport, nuclear
fast: false
reactant: MODEL1310110021#

metaR r2197
kinetic law: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_98bed0db_2332_40e4_b3b4_1e7abd6de7a5
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is: Q969K7
name: TMEM54
is encoded by: hsa:113452
has only substance units: false
initial concentration: NaN

metaR r0160
type: Reaction
reversible: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is: SBO:0000176
product: MODEL1310110021#
is described by: ECO:0000000
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
is version of: http://identifiers.org/ec-code/2.1.3.2
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_4522e213_d8a0_44b9_8f56_214fe14c5b37
is: P14550
boundary condition: true
is encoded by: hsa:10327
has only substance units: false
constant: false
is: SBO:0000252
name: AKR1A1
type: Species
initial amount: NaN
initial concentration: NaN

metaR EX hcoumarin LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxy coumarin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_791203a7_0e2d_471a_ba36_7932592e311b
name: DGUOK
initial concentration: NaN
is: E5KSL6
initial amount: NaN
is encoded by: hsa:1716
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaM cs c deg5 l
initial amount: NaN
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5
initial concentration: 1.0
is: CHEBI:15936
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C23H36O24S CHARGE: -2
type: Species

metaM retinol 9 cis c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
constant: false
is: HMDB06217
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:17336
name: 9-cis-retinol

metaM orn e
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C01602
has only substance units: false
type: Species
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
constant: false
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110021#_605fcf88_db6b_43b3_879c_dfeaece68ec3
is: O75610
type: Species
constant: false
is encoded by: hsa:10637
boundary condition: true
initial amount: NaN
name: LEFTY1
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_507193e0_78b1_4771_94b1_2429735aadfa
is: Q9Y2A9
name: B3GNT3
constant: false
boundary condition: true
is encoded by: hsa:10331
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM dgsn c
name: Deoxyguanosine
is: SBO:0000247
is: CHEBI:17172
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
type: Species
initial concentration: 1.0
is: HMDB00085
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_8d1d8c6b_7a28_423e_87cc_237c90f6d43d
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:6550
is: P48764
name: SLC9A3
initial concentration: NaN

metaR r2106
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110021#
product: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM malcoa c
boundary condition: false
initial concentration: 1.0
is: HMDB01175
initial amount: NaN
type: Species
is: CHEBI:57384
is: C00083
name: Malonyl-CoA
is: SBO:0000247
has only substance units: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_73560198_d2a9_4401_aba9_20c9821c1471
constant: false
is: Q99884
is encoded by: hsa:6534
name: SLC6A7
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_27ab0f3b_1880_4b8d_9019_88be609959cb
name: CAD
is: P27708
has only substance units: false
constant: false
is encoded by: hsa:790
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM dcdp c
is: SBO:0000247
boundary condition: false
is: C00705
name: dCDP
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
has only substance units: false
is: CHEBI:58593
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species

metaM ins e
boundary condition: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
is: HMDB00195
is: SBO:0000247
type: Species
name: Inosine
is: C00294
has only substance units: false
constant: false
is: CHEBI:17596
initial amount: NaN

metaR r2194
is described by: ECO:0000000
modifier: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f5aa0a0c_4362_49b1_9b73_5a9b203fe072
name: GCH1
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: Q8IZH9
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2643

metaR GLNS
is described by: ECO:0000254
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: false
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.15
is: SBO:0000176
product: MODEL1310110021#
name: glutamine synthetase
fast: false

metaR NDPK4n
is described by: ECO:0000304
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

metaM acgam r
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
name: N-acetyl-D-glucosamine
type: Species
initial concentration: 1.0
is: HMDB00215
constant: false

metaR FAOXC81C61m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR r2101
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
reversible: true
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM oaa c
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00036
notes: FORMULA: C4H2O5 CHARGE: -2
is: HMDB00223
type: Species
name: Oxaloacetate
initial amount: NaN
has only substance units: false
is: CHEBI:3338
boundary condition: false

metaR PItg
reactant: MODEL1310110021#
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110021#
name: phosphate transport, Golgi apparatus

metaM mthgxl c
name: methylglyoxal
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:17158
is: HMDB01167
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_bdc8d8df_698e_4de8_856e_1a99c178e48e
is: Q92536
is encoded by: hsa:9057
initial concentration: NaN
name: SLC7A6
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1abe58c1_1511_47b2_93c0_471e3e24fea0
name: _AL048840_1_c
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AL048840
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_4745fdec_0746_4ecc_b101_0b43997c73a7
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: P49189
initial concentration: NaN
name: ALDH9A1
is encoded by: hsa:223
has only substance units: false

metaR FAOXC184C164m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_1d6fb2d2_d9c1_4602_8ee4_a0cfc9e219f0
constant: false
is: O94903
has only substance units: false
is encoded by: hsa:11212
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: PROSC
is: SBO:0000252

metaR NS26T2g
fast: false
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
reversible: false
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
modifier: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.3
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction

metaM 5adtststerone e
is: HMDB02961
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16330
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_52c85c98_85d9_4a57_8c6b_98b7ef1c83f5
is: SBO:0000252
has only substance units: false
is: D9HTE9
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:6576
name: SLC25A1

metaM xyl D e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: CHEBI:15936
name: aldehydo-D-xylose
boundary condition: false
constant: false
has only substance units: false

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110021#_ea0494fe_bea9_4196_88d5_eefc35ca9080
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AA081045
name: _AA081045_1_c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaR OCCOAtx
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
product: MODEL1310110021#
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000

metaM 2mbcoa m
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01041
is: CHEBI:57336
has only substance units: false
name: 2-methylbutanoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033

http://identifiers.org/biomodels.db/MODEL1310110021#_ffd7487c_01a5_4542_a6e9_a2afcec9be25
is: SBO:0000252
is: P54868
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:3158
initial amount: NaN
initial concentration: NaN
name: HMGCS2

metaR PROt2r
name: L-proline reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
is described by: ECO:0000304
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction

metaR r2195
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110021#
reversible: true

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaM T antigen g
type: Species
is: CHEBI:22783
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C14H24NO10X CHARGE: 0
boundary condition: false
has only substance units: false
name: T antigen (core 1)
initial concentration: 1.0
constant: false

metaR INSTt4
is described by: ECO:0000269
product: MODEL1310110021#
reversible: true
name: inositol transport via sodium symport
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185

metaR r2100
modifier: MODEL1310110021#
is described by: ECO:0000000
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM ipdp x
is: HMDB01347
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
name: isopentenyl diphosphate(3-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:128769
has only substance units: false
initial concentration: 1.0
type: Species

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110021#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#

metaM orn c
initial concentration: 1.0
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
is: CHEBI:0
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
is: C01602
has only substance units: false

metaR EAFLATOXINte
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reactant: MODEL1310110021#
fast: false
name: xenobiotic transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_d5303c53_a3c9_4eb8_a9ee_86f00335fafa
has only substance units: false
type: Species
is: SBO:0000252
name: PIP5K1A
is encoded by: hsa:8394
initial concentration: NaN
initial amount: NaN
is: Q99755
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_6015d2e8_5346_4339_8e48_15e6da800b4e
boundary condition: true
is: SBO:0000252
constant: false
name: RHAG
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:6005
is: Q96E98

metaM triodthy e
is: HMDB00265
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 3,3',5-triiodo-L-thyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:18258

http://identifiers.org/biomodels.db/MODEL1310110021#_58481969_3e67_417d_90cf_d37535d8c7aa
constant: false
is: SBO:0000252
is encoded by: hsa:22305
name: _22305_2_c
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaM adpcoa x
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: C14143
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: HMDB04047
initial concentration: 1.0
has only substance units: false
type: Species
name: adipoylcoa

metaM HC01434 x
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
name: oxalatosuccinate(3-)
initial concentration: 1.0
constant: false
is: CHEBI:58931
is: SBO:0000247

metaM thmmp c
type: Species
is: C01081
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
constant: false
boundary condition: false
is: HMDB02666
is: CHEBI:37575
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Thiamin monophosphate

http://identifiers.org/biomodels.db/MODEL1310110021#_0453db44_2798_4ae3_8344_a55ec40c2df2
is encoded by: hsa:AI926493
initial amount: NaN
initial concentration: NaN
name: _AI926493_1_c
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_2d70e951_e797_42ec_9b5e_0e26982f3b16
boundary condition: true
is: O60427
initial amount: NaN
name: FADS1
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3992
type: Species

metaR SERtN1
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000269
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
name: Serine transport (Na, H coupled)
is: SBO:0000185
product: MODEL1310110021#
fast: false

metaR O2St
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
name: superoxide anion transport via diffusion (extracellular)
product: MODEL1310110021#
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000

metaR RE1525M
reversible: true
name: RE1525
kinetic law: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110021#
fast: false

metaR RE1518M
fast: false
product: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
reversible: true
is described by: ECO:0000000
name: RE1518
is: SBO:0000176
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_9be7414a_1873_49a4_9828_6971b30a3220
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: O00746
is: SBO:0000252
type: Species
name: NME4
has only substance units: false
is encoded by: hsa:4833

metaR PI4PLC
modifier: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: phosphatidylinositol 4-phosphate phospholipase C
reversible: false
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
fast: false
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_f2c2da8e_b144_41d8_bfc0_3b0b92e2d710
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4953
is: SBO:0000252
constant: false
is: P11926
initial amount: NaN
name: ODC1

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM dhlam m
type: Species
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
is: HMDB00985
is: CHEBI:17694
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: dihydrolipoamide
constant: false
boundary condition: false

metaR r0809
reactant: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
fast: false
modifier: MODEL1310110021#
name: Facilitated diffusion
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:

metaM 4abutn m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: CHEBI:58264
name: 4-ammoniobutanal
constant: false
boundary condition: false
is: HMDB01080
initial amount: NaN
type: Species

metaR ST8SIA11
modifier: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.4.99.8
kinetic law: MODEL1310110021#
name: Beta-galactoside alpha-2,3-sialyltransferase
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_b5fc7c33_f047_400d_815f_8a1e148c6900
initial amount: NaN
is encoded by: hsa:79611
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: ACSS3
is: Q9H6R3
boundary condition: true
initial concentration: NaN

metaR ALAtN1
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110021#
name: Alanine transport (Na, H coupled)
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true
fast: false

metaR r2103
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_928ec51e_63b2_4654_9653_8e832136ab16
is encoded by: hsa:5167
is: P22413
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: ENPP1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_30390da9_c628_4b51_81b7_fee8401e59fa
initial concentration: NaN
is encoded by: hsa:7498
is: P47989
type: Species
name: XDH
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_1f718d14_c520_476e_b2da_8bcd5d03ec8c
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5295
constant: false
is: SBO:0000252
initial amount: NaN
is: P27986
name: PIK3R1
has only substance units: false
type: Species

metaR r2193
product: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
reversible: true
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM arachdcrn m
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:57387
is: HMDB01322
initial concentration: 1.0
name: C20:4 carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236

metaR r0899
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
reversible: true
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
name: Amino acid transporter ATB0+ Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185

metaM xyl D c
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:15936
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose

http://identifiers.org/biomodels.db/MODEL1310110021#_79966529_8c01_40d9_9fdb_145a4883108f
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: ALDH4A1
is encoded by: hsa:8659
constant: false
has only substance units: false

metaR r2102
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110021#
reversible: true
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR r0688
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
type: Reaction

metaR GULLACter
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
name: gulonolactone endoplasmic reticular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
kinetic law: MODEL1310110021#

metaR BTNt2
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
reversible: true
product: MODEL1310110021#
fast: false
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: Biotin reversible transport via proton symport
is: SBO:0000185
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_bb9d5d69_3e65_42fb_a843_8e4678dbcae0
has only substance units: false
is encoded by: hsa:622
type: Species
name: BDH1
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_7877c60d_8254_4dea_9768_2576b8f53e24
type: Species
constant: false
is: SBO:0000252
is: O14735
has only substance units: false
boundary condition: true
is encoded by: hsa:10423
name: CDIPT
initial amount: NaN
initial concentration: NaN

metaM bhb m
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
has only substance units: false
is: SBO:0000247
name: (R)-3-hydroxybutyrate
type: Species
is: CHEBI:10983
is: HMDB00011
constant: false
initial amount: NaN
initial concentration: 1.0

metaM retinal cis 9 c
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
name: all-trans-retinal
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17898
initial concentration: 1.0
is: HMDB01358
is: SBO:0000247

metaR ST8SIA12
reversible: false
reactant: MODEL1310110021#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
is: SBO:0000176
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.4.99.8
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
name: Beta-galactoside alpha-2,3-sialyltransferase

metaR RE0689E
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000000
fast: false
reactant: MODEL1310110021#
name: RE0689
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaM atp c
constant: false
is: CHEBI:30616
initial amount: NaN
is: C00002
is: HMDB00538
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: ATP(4-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_6f2b0ac4_7fa3_433a_a295_4a92a8c55137
is: SBO:0000252
initial concentration: NaN
name: NDUFA4L2
boundary condition: true
has only substance units: false
is encoded by: hsa:56901
type: Species
is: Q9NRX3
constant: false
initial amount: NaN

metaR BALAtmr
type: Reaction
reactant: MODEL1310110021#
name: Beta-alanine reversible mitochondrial transport (diffusion)
reversible: true
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110021#_e8b13893_aa1f_4d3d_9999_75840306e9f0
is encoded by: hsa:4722
type: Species
initial concentration: NaN
is: O75489
initial amount: NaN
has only substance units: false
name: NDUFS3
constant: false
boundary condition: true
is: SBO:0000252

metaM triodthy c
is: CHEBI:18258
has only substance units: false
is: HMDB00265
name: 3,3',5-triiodo-L-thyronine
constant: false
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR DADA
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is described by: ECO:0000269
name: Deoxyadenosine deaminase
is version of: http://identifiers.org/ec-code/3.5.4.4
reactant: MODEL1310110021#
fast: false

metaM taur e
type: Species
name: Taurine
constant: false
is: HMDB00251
has only substance units: false
initial concentration: 1.0
is: CHEBI:3544
is: C00245
notes: FORMULA: C2H7NO3S CHARGE: 0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM dcamp c
is: CHEBI:57567
constant: false
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
initial amount: NaN
is: SBO:0000247
is: C03794
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: N6-(1,2-Dicarboxyethyl)-AMP
type: Species
is: HMDB00536

http://identifiers.org/biomodels.db/MODEL1310110021#_426200f7_ae3b_45b1_bfc3_c23a7af54bbd
name: CA13
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:377677
initial concentration: NaN
constant: false
is: Q8N1Q1

metaR GLUTCOADHm
reversible: false
reactant: MODEL1310110021#
name: glutaryl-CoA dehydrogenase (mitochondria)
is: SBO:0000176
fast: false
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.3.99.7

metaR EX nadp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide adenine dinucleotide phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_653e0a2d_6fa6_4464_b049_be823f088e09
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
name: TXNRD1
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7296

metaR 7DHFtm
is described by: ECO:0000000
name: 7-glutamyl-DHF transport,m mitochondrial
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_2d6a9167_73ee_4ac2_8b2a_10868a1e44a0
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2348
constant: false
name: FOLR1
initial amount: NaN
initial concentration: NaN

metaR P5CR
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
fast: false
name: pyrroline-5-carboxylate reductase
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_b8c0f923_a986_4f33_9cb9_7429a525d08f
is: SBO:0000252
name: HAS3
initial amount: NaN
constant: false
is: O00219
boundary condition: true
has only substance units: false
is encoded by: hsa:3038
initial concentration: NaN
type: Species

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR r0456
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
reversible: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110021#

metaR PI345P5P
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_f7ad6016_7b96_48e9_826e_eb5c6aa40a9a
initial amount: NaN
is encoded by: hsa:3635
is: SBO:0000252
has only substance units: false
name: INPP5D
boundary condition: true
is: Q92835
type: Species
initial concentration: NaN
constant: false

metaR r2363
type: Reaction
reversible: true
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_6ac170be_8922_4897_871d_54beb0f4c751
initial amount: NaN
type: Species
boundary condition: true
is: A0S0A7
is encoded by: hsa:4846
name: NOS3
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaR r0717
is: SBO:0000176
kinetic law: MODEL1310110021#
reversible: false
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
type: Reaction

metaM atp m
constant: false
is: C00002
has only substance units: false
is: CHEBI:57299
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: ATP(4-)
initial amount: NaN
is: HMDB00538

http://identifiers.org/biomodels.db/MODEL1310110021#_31c74f30_e0d8_4329_8b10_c6bae22c9a8a
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC35A1
is: P78382
is encoded by: hsa:10559
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d5dde4ee_ef55_43be_8e22_7de29a4dd7e8
has only substance units: false
type: Species
name: _AI348006_1_c
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI348006
is: SBO:0000252
constant: false
initial concentration: NaN

metaR AMPDA
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.6
kinetic law: MODEL1310110021#
reversible: false
name: Adenosine monophosphate deaminase
modifier: MODEL1310110021#
is described by: ECO:0000269
type: Reaction

metaM 3mob m
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
is: CHEBI:11851
boundary condition: false
name: 3-methyl-2-oxobutanoate
initial amount: NaN
is: HMDB00019
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false

metaM 5adtststerone r
boundary condition: false
is: HMDB02961
is: CHEBI:16330
initial amount: NaN
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_21408cc9_4afe_48ff_9c30_dafc437f32a5
is: O76062
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:7108
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: TM7SF2

metaR GGH 10FTHF7GLUe
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
fast: false
is described by: ECO:0000000
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110021#
is: SBO:0000176
reversible: false

metaR B3GNT39g
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
product: MODEL1310110021#

metaR PI34P5K
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
reversible: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#

metaR r2362
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM HC02208 c
initial amount: NaN
is: CHEBI:27696
boundary condition: false
is: SBO:0000247
name: prostaglandin-d1
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_7240235b_d2b1_4546_8463_d74e175446e6
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:412
initial amount: NaN
name: STS
has only substance units: false
is: P08842

http://identifiers.org/biomodels.db/MODEL1310110021#_90732383_8896_4435_82f8_0fff09e17e52
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:51196
name: PLCE1
is: Q9P212
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_2800282c_d469_4c53_9e58_c4a677fdb28e
name: HMGCS2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3158
boundary condition: true
initial amount: NaN
is: P54868
type: Species
constant: false

metaM HC00319 m
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:30794
name: Malonate
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false

metaM dtdp m
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00363
type: Species
name: dTDP
is: CHEBI:58369
has only substance units: false

metaM atp n
type: Species
is: SBO:0000247
is: CHEBI:57299
boundary condition: false
name: ATP(3-)
initial concentration: 1.0
initial amount: NaN
is: HMDB00538
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
has only substance units: false

metaR r0716
kinetic law: MODEL1310110021#
reversible: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000

metaR SUCCOAPET
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_1ff886be_bb4f_4887_bd65_4837e3ce0c08
name: ACAA1
is encoded by: hsa:30
initial amount: NaN
has only substance units: false
is: Q96CA6
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_b11f93e0_b84c_4ac6_aa3a_695a78156cae
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: _NM_013421_1_m
initial concentration: NaN
is encoded by: hsa:NM 013421
boundary condition: true

metaM taur c
initial amount: NaN
name: Taurine
has only substance units: false
type: Species
is: HMDB00251
initial concentration: 1.0
constant: false
is: CHEBI:3544
notes: FORMULA: C2H7NO3S CHARGE: 0
boundary condition: false
is: C00245
is: SBO:0000247

metaM nicrnt c
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
initial amount: NaN
is: CHEBI:57502
constant: false
is: HMDB01132
is: C01185
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: Nicotinate D-ribonucleotide

http://identifiers.org/biomodels.db/MODEL1310110021#_641d625f_63ff_4a09_8103_20e4ba39b395
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:7084
type: Species
name: TK2
boundary condition: true
is: O00142
initial amount: NaN

metaM dgmp m
is: CHEBI:57673
initial concentration: 1.0
is: C00362
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
name: dGMP
boundary condition: false

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaR RDH1a
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.300
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.105
reversible: true
product: MODEL1310110021#
name: retinol dehydrogenase (all-trans,NADPH)
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000269

metaM cholcoar r
is: CHEBI:58677
constant: false
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
has only substance units: false
initial amount: NaN
is: HMDB02178
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_5838f4dd_825a_4faf_8c63_3b9edf9e60ef
is: Q92523
is encoded by: hsa:1375
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: CPT1B
type: Species

metaR r0796
modifier: MODEL1310110021#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reversible: true
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction

metaR r2365
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_ef4e8235_d034_4691_90f0_b1fd73ec632e
constant: false
is: P20674
name: COX5A
type: Species
is encoded by: hsa:9377
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r0715
is version of: http://identifiers.org/ec-code/6.3.2.5
type: Reaction
kinetic law: MODEL1310110021#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

metaM dtdp n
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
is: CHEBI:58369
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
type: Species

metaM so3 m
is: HMDB00240
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
name: hydrogensulfite
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
is: CHEBI:17137

http://identifiers.org/biomodels.db/MODEL1310110021#_66a316c4_c22d_4992_9a33_882f8ca02b7b
initial concentration: NaN
is encoded by: hsa:6535
name: SLC6A8
has only substance units: false
is: B4DIA3
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaR MI4PP
reactant: MODEL1310110021#
reversible: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.3.25
modifier: MODEL1310110021#
fast: false
name: myo-inositol 4-phosphatase
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
kinetic law: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_e69c0a84_3251_4c1b_a2c3_c1c353f16e13
constant: false
is encoded by: hsa:5831
boundary condition: true
is: A6NFM2
name: PYCR1
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_17c53f68_c509_49f7_bc60_bf1849bb625b
has only substance units: false
name: MAOA
constant: false
is encoded by: hsa:4128
initial concentration: NaN
is: Q53YE7
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR ICDHyrm
name: Isocitrate dehydrogenase (NADP+)
type: Reaction
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF

metaM CE1944 c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:36781
type: Species
initial amount: NaN
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
name: 1-pyrrolinium
constant: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR r0797
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
name: glycine N-choloyltransferase EC:2.3.1.65
type: Reaction
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:

metaR r2364
fast: false
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
reversible: true

metaM HC02208 e
has only substance units: false
is: CHEBI:27696
boundary condition: false
is: SBO:0000247
constant: false
name: prostaglandin-d1
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110021#_3ae4345f_edd2_4257_b10a_7d09e8cac29f
is: SBO:0000252
boundary condition: true
name: HK1
initial amount: NaN
is: P78542
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:3098
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_a471d7a5_273f_4960_ae0e_9d2b46087ff4
initial amount: NaN
name: LDHD
boundary condition: true
is encoded by: hsa:197257
is: Q86WU2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaR r0714
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
reversible: false

metaR DM T antigen g
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_e5dfc057_88ed_41fa_8fae_ab4aa346a73c
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: MTHFD1
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: P11586
is encoded by: hsa:4522

metaM pail hs c
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
is: CHEBI:57880
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247

metaR ACACT7p
fast: false
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
reversible: false
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110021#

metaR r0381
product: MODEL1310110021#
is: SBO:0000176
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_eb6ca33c_c235_4c8f_8939_c4ad9f0f92e8
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1719
constant: false
is: P00374
is: SBO:0000252
name: DHFR
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1c1a9978_7b1b_4aea_9994_448adc8872ac
is encoded by: hsa:272
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: B7Z763
name: AMPD3
boundary condition: true
initial amount: NaN

metaR PRPNCOAHYDm
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
product: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.18
name: Propenoyl-CoA hydrolase (m)
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r2109
reactant: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM adrn e
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
initial amount: NaN
name: adrenic acid
boundary condition: false
has only substance units: false
is: CHEBI:53487
type: Species
constant: false
is: HMDB02226
is: SBO:0000247

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR RE3218C
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: true
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
fast: false
name: RE3218
reactant: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_4e08eceb_8eb1_4618_9e73_3893813e94ea
is: Q96P26
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: NT5C1B
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:93034

metaR PPD2CSPp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: PPD2CSPp
fast: false
reactant: MODEL1310110021#

metaR RE3520E
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
is: SBO:0000176
name: RE3520
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9

http://identifiers.org/biomodels.db/MODEL1310110021#_95aa18bc_9ed6_4f48_8d1a_d89de15953d8
is: P22392
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: NME2
is encoded by: hsa:4831
has only substance units: false
is: SBO:0000252
type: Species
constant: false

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaR CRNtx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
name: carnitine transport peroxisome to mitochondria
product: MODEL1310110021#

metaM gly m
initial concentration: 1.0
is: CHEBI:15428
has only substance units: false
is: HMDB00123
type: Species
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
name: Glycine
is: C00037
initial amount: NaN
boundary condition: false

metaM glyald c
constant: false
type: Species
is: HMDB01051
is: CHEBI:17378
name: D-Glyceraldehyde
boundary condition: false
initial amount: NaN
is: C00577
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
has only substance units: false

metaR r2081
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110021#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM lnlncgcoa c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
is: CHEBI:57363
initial amount: NaN
boundary condition: false
constant: false
type: Species

metaR CYTK6n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: cytidylate kinase (CMP,CTP),nuclear
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
fast: false

metaR ASPTA
is described by: ECO:0000269
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110021#
reversible: true
name: aspartate transaminase
fast: false
is: SBO:0000176
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:

metaM thmmp m
boundary condition: false
has only substance units: false
is: CHEBI:37575
initial amount: NaN
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
is: HMDB02666
initial concentration: 1.0
type: Species
name: thiamine(1+) monophosphate(2-)
constant: false
is: SBO:0000247

metaR r2000
reversible: false
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_5dca621d_d808_4f89_b938_592c7d50f2e3
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: SGPP2
is: Q8IWX5
is encoded by: hsa:130367

http://identifiers.org/biomodels.db/MODEL1310110021#_5914671a_429e_4a5a_9a90_5acfaa11fc81
is encoded by: hsa:8869
is: SBO:0000252
initial amount: NaN
name: ST3GAL5
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: Q9UNP4
type: Species

metaR r0791
modifier: MODEL1310110021#
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110021#

metaR DNDPt26m
is: SBO:0000185
fast: false
name: dCDP transport via dUDP antiport
reactant: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
product: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#

metaM arachdcrn x
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:57368
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: SBO:0000247
initial amount: NaN
is: HMDB06523
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_7d902c9a_574e_4f40_8643_3873c6f01275
boundary condition: true
name: ATP10A
is encoded by: hsa:57194
has only substance units: false
type: Species
is: O60312
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaM xan c
boundary condition: false
type: Species
name: Xanthine
is: C00385
initial amount: NaN
is: SBO:0000247
is: HMDB00292
is: CHEBI:17712
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial concentration: 1.0
has only substance units: false
constant: false

metaR FAOXC164m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR r2108
is described by: ECO:0000000
type: Reaction
product: MODEL1310110021#
is: SBO:0000185
reversible: true
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0451
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_6391aac0_8e6c_415e_8fb2_5a8a026545c2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:H77542
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: _H77542_1_c

http://identifiers.org/biomodels.db/MODEL1310110021#_d31ca26c_97ad_4dff_8817_ad6b14705613
type: Species
constant: false
name: PYCR1
is: SBO:0000252
is: A6NFM2
boundary condition: true
is encoded by: hsa:5831
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_ef78359c_c147_4dfe_b27f_7060fa6d04d5
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: PKLR
has only substance units: false
is encoded by: hsa:5313
is: P30613
boundary condition: true

metaM HC02180 e
is: CHEBI:28728
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: thromboxane-b2
has only substance units: false
type: Species
is: SBO:0000247

metaR ORNALArBATtc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaR r2082
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110021#_51e0bf00_ff0d_4e03_b9c6_a0bc2f167109
is: P32929
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: CTH
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:1491

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_2c17287e_54a4_4918_81bd_19eb17499add
initial concentration: NaN
is encoded by: hsa:956
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: O75355
type: Species
name: ENTPD3

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaM C05957 r
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB02710
initial concentration: 1.0
is: CHEBI:27485
boundary condition: false
initial amount: NaN
constant: false
name: Prostaglandin J2

metaR r0913
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_9adfb109_2fcf_480d_b2bd_e1d4c6b05a43
has part: Q53XN1
has part: P13073
is encoded by: hsa:1346
has part: Q7Z4L0
is encoded by: hsa:4512
is encoded by: hsa:1329
is encoded by: hsa:1327
is encoded by: hsa:1337
has part: Q02221
has part: P15954
is encoded by: hsa:9377
has part: Q96KJ9
is encoded by: hsa:1347
has part: P09669
is encoded by: hsa:1345
constant: false
is encoded by: hsa:341947
has part: P12074
initial amount: NaN
is encoded by: hsa:84701
has part: P20674
has part: P14854
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1339
has part: Q7GXY8
has part: Q53YB7
has part: P24311
is encoded by: hsa:1351
has part: P00414
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:125965
has part: Q7GXZ8
is encoded by: hsa:4514
is: SBO:0000297
has part: Q6FGA0
boundary condition: true
has part: Q8TF08
is encoded by: hsa:9167
has part: Q6YFQ2
is encoded by: hsa:1340
is encoded by: hsa:1350
is encoded by: hsa:1349
has part: H0UI06
has part: P24310
is encoded by: hsa:170712
is encoded by: hsa:4513

metaR FAOXC140
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM HC01409 m
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
constant: false
has only substance units: false
is: CHEBI:27540
boundary condition: false
type: Species
initial concentration: 1.0
name: Hexanoyl-CoA

metaR DALAt2r
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
kinetic law: MODEL1310110021#
is: SBO:0000185
fast: false
name: D-alanine transport via proton symport
is described by: ECO:0000304
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#

metaR S23Tg
kinetic law: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: false
type: Reaction
product: MODEL1310110021#
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000269

metaM adrn c
initial concentration: 1.0
name: adrenic acid
is: CHEBI:53487
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB02226
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110021#_80cc7056_a33f_4c9a_8429_06402b41e644
name: CYP51A1
is: Q16850
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1595
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR GALt1r
fast: false
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
is described by: ECO:0000269
name: galactose transport (uniport)
reactant: MODEL1310110021#
modifier: MODEL1310110021#

metaR HCOUMARINte
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
name: xenobiotic transport
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
type: Reaction

metaR FAOXC163GC142m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_1b881f92_bb65_41f3_b94a_a12ea63f7069
has only substance units: false
constant: false
initial amount: NaN
name: TKTL1
is: B7Z7I0
boundary condition: true
is encoded by: hsa:8277
is: SBO:0000252
type: Species
initial concentration: NaN

metaR q10h2tc
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000185
name: transport of ubiquinol into cytosol

http://identifiers.org/biomodels.db/MODEL1310110021#_fe42f6d5_6adc_4503_b1c5_71d73f268132
type: Species
is encoded by: hsa:6517
initial amount: NaN
has only substance units: false
constant: false
name: SLC2A4
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P14672

metaM 20ahchsterol m
initial amount: NaN
is: HMDB06283
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
name: 20-hydroxycholesterol
is: CHEBI:1296
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_63d8d894_cf72_432d_a72a_1800102e8a43
initial concentration: NaN
has only substance units: false
is: P35790
is: SBO:0000252
constant: false
is encoded by: hsa:1119
type: Species
initial amount: NaN
name: CHKA
boundary condition: true

metaR PHEyLATthc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Phenylalanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR r2002
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false
modifier: MODEL1310110021#

metaR GGH 6DHFe
is described by: ECO:0000000
reversible: false
name: Gamma-glutamyl hydrolase (6DHF), extracellular
fast: false
is: SBO:0000176
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110021#_2e2da508_366c_46ca_9752_b17c9284f1b7
initial concentration: NaN
type: Species
name: EHHADH
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:1962
is: SBO:0000252
is: Q9NY65
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_1125ccae_f637_463d_927f_aa23daece4ad
constant: false
has only substance units: false
is encoded by: hsa:NM 001929
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _NM_001929_1_c
type: Species

metaR r2361
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
is described by: ECO:0000000

metaR 7DHFtl
reversible: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
name: 7-glutamyl-DHF transport, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110021#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction

metaM gd3 hs g
has only substance units: false
is: CHEBI:28424
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: GD3
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_a432cdcc_5ac6_4caf_8be1_f0bccbe0904e
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: E7EML0
is encoded by: hsa:9498
is: SBO:0000252
type: Species
constant: false
name: SLC4A8

metaR 3MOBte
reversible: true
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
fast: false
reactant: MODEL1310110021#
name: Transport of 3-methyl-2-oxobutanoate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR DGNSKm
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110021#
name: deoxyguanosine kinase
is: SBO:0000176
fast: false
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.113

http://identifiers.org/biomodels.db/MODEL1310110021#_13debb9d_d377_4dd3_9be1_3ed049a78fd6
is: P53794
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6526
has only substance units: false
name: SLC5A3

metaR r0680
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
modifier: MODEL1310110021#
type: Reaction
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.137

metaM HC02180 c
has only substance units: false
name: thromboxane-b2
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28728
boundary condition: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_72e737d9_d86a_40bc_8c3e_884319b4fea1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54576
initial amount: NaN
constant: false
is: Q5DSZ6
type: Species
name: UGT1A8
boundary condition: true
is: SBO:0000252

metaR FACOAL180i
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
kinetic law: MODEL1310110021#
reversible: false
modifier: MODEL1310110021#
name: C180 fatty acid activation
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction
product: MODEL1310110021#

metaR CYTK12n
modifier: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reactant: MODEL1310110021#
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_51a7f76c_5ef8_4ca4_a17b_d77622fa1e2e
is: E9PB82
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:3295
is: SBO:0000252
type: Species
name: HSD17B4
boundary condition: true
has only substance units: false

metaR r2080
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_394c4110_c71d_4162_8369_e3601ff3b99f
name: COX7A2
boundary condition: true
has only substance units: false
is: H0UI06
is encoded by: hsa:1347
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_ec9b2f24_0680_4d10_9580_ad195674f620
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9153
is: O43868
type: Species
name: SLC28A2
constant: false

metaR r0915
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110021#

metaR r1846
product: MODEL1310110021#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Y+LAT2 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_db78dd96_b910_4b80_9e78_4d4168e23c2a
is: SBO:0000252
is encoded by: hsa:54539
name: NDUFB11
initial amount: NaN
is: Q9NX14
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR r2360
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_9f9591e5_dfd3_4b8b_b130_7a67ac5ee8aa
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: SLC12A4
is encoded by: hsa:6560
has only substance units: false
boundary condition: true
is: F5H066
initial amount: NaN

metaM glac r
initial amount: NaN
is: HMDB06355
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
has only substance units: false
constant: false
is: CHEBI:18268
name: D-glucurono-6,3-lactone

metaR r2086
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
reversible: true
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#

metaM CE0233 c
type: Species
is: HMDB01993
name: 5beta-cholestane-3alpha,7alpha,27-triol
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1/C27H48O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h17-24,28-30H,6-16H2,1-5H3/t17-,18-,19+,20-,21-,22-,23+,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE0233
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:17899

metaR AKGtp
is: SBO:0000185
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
fast: false
type: Reaction
reversible: true
name: AKG transporter, peroxisome
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaR ALDD2y
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110021#_f31e0641_1fb0_4a85_b09b_7d017daabd14
initial amount: NaN
type: Species
name: TXNRD3
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:114112
boundary condition: true
is: Q86VQ6
is: SBO:0000252

metaR RE2677E
reversible: false
reactant: MODEL1310110021#
name: RE2677
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
type: Reaction
kinetic law: MODEL1310110021#

metaR ALAR
name: alanine racemase
modifier: MODEL1310110021#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000212
fast: false
reactant: MODEL1310110021#

metaR GGH 6THFe
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110021#
type: Reaction
name: Gamma-glutamyl hydrolase (6THF), extracellular
is: SBO:0000176
modifier: MODEL1310110021#

metaR AMETtd
is: SBO:0000185
product: MODEL1310110021#
is described by: ECO:0000134
reactant: MODEL1310110021#
name: diffusion of S-Adenosyl-L-methionine
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_4a92792a_174d_4044_9e51_510279a31644
constant: false
has only substance units: false
is encoded by: hsa:AV717590
boundary condition: true
initial amount: NaN
name: _AV717590_1_m
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r0921
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
product: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
reactant: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_40cfd740_f7c9_4aab_81dd_547e3fd5500b
type: Species
initial amount: NaN
initial concentration: NaN
name: HAS1
is encoded by: hsa:3036
has only substance units: false
boundary condition: true
is: Q8IYH3
is: SBO:0000252
constant: false

metaM acgal l
is: SBO:0000247
type: Species
name: N-acetyl-D-galactosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
is: HMDB00212
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28037
has only substance units: false
constant: false

metaR MI1PP
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reversible: false
product: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.3.25
fast: false
type: Reaction
kinetic law: MODEL1310110021#
name: myo-inositol 1-phosphatase
reactant: MODEL1310110021#

metaR TPI
product: MODEL1310110021#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
kinetic law: MODEL1310110021#
is described by: ECO:0000134
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/5.3.1.1
name: triose-phosphate isomerase
type: Reaction
fast: false
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_58418a36_96ef_439e_8258_78673302a89e
is encoded by: hsa:84105
initial amount: NaN
is: SBO:0000252
is: Q9H0N5
name: PCBD2
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_77381fd7_3656_4e7b_ba80_09bac2f16907
is encoded by: hsa:8503
type: Species
initial concentration: NaN
is: SBO:0000297
name: PIK3CD:PIK3R3
is encoded by: hsa:5293
initial amount: NaN
constant: false
has part: Q92569
has only substance units: false
has part: A7E2E0
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_5653e5a0_8ae1_493e_a284_75ce268bb183
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1109
is: P17516
initial amount: NaN
name: AKR1C4
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_5cc79e2d_ce3b_4489_a92c_57199fc068f1
name: GMPPA
is encoded by: hsa:29926
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q96IJ6
initial concentration: NaN
constant: false
has only substance units: false
type: Species

metaM C05280 m
is: SBO:0000247
is: CHEBI:28002
type: Species
constant: false
name: cis,cis-3,6-Dodecadienoyl-CoA
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB03952
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280

metaM dtdp e
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
has only substance units: false
is: HMDB01274
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:58369
constant: false
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

http://identifiers.org/biomodels.db/MODEL1310110021#_92b043a6_e588_4697_a6db_a065e4ebf4e0
is: SBO:0000252
name: HK2
is encoded by: hsa:3099
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P52789
has only substance units: false
constant: false
type: Species

metaM trp L c
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial concentration: 1.0
has only substance units: false
name: L-tryptophan
is: CHEBI:16828
initial amount: NaN
type: Species
is: HMDB00929
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_49231dad_28d9_4f2f_8334_4b7bb811c7f7
is encoded by: hsa:5832
type: Species
initial concentration: NaN
is: P54886
constant: false
boundary condition: true
name: ALDH18A1
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR r2358
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110021#
reversible: true
fast: false
type: Reaction
product: MODEL1310110021#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110021#

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR r2085
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false

metaR TYRt
name: L-tyrosine transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reversible: true
modifier: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_c4dfea79_fddf_4d97_b4a5_bc21ba8856f8
name: DGKI
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:9162
is: SBO:0000252
constant: false
initial amount: NaN
is: O75912

metaM his L c
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
initial amount: NaN
has only substance units: false
is: HMDB00177
type: Species
constant: false
boundary condition: false
is: CHEBI:15971
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_7439b601_c731_4e00_b766_42084d7e0219
name: RHBG
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:57127
is: Q9H310

http://identifiers.org/biomodels.db/MODEL1310110021#_130f8756_e0a3_4cc4_9549_3a6d314d9f12
initial amount: NaN
is: SBO:0000252
is: B7Z4Y6
type: Species
name: ALPL
is encoded by: hsa:249
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_c682bb42_6091_412e_94ce_e053dd4fdefc
boundary condition: true
is encoded by: hsa:1346
initial concentration: NaN
name: COX7A1
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: P24310

metaR RE3556C
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3556
is: SBO:0000176
type: Reaction

metaR TCHOLAtx
reactant: MODEL1310110021#
name: bile acid intracellular transport
fast: false
is: SBO:0000185
product: MODEL1310110021#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_cbddca3b_c59d_4341_aa67_7e005bacbc38
boundary condition: true
is encoded by: hsa:80025
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: Q6P1K9
name: PANK2
constant: false

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM CE5126 x
type: Species
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
constant: false
boundary condition: false
has only substance units: false
name: (2R)-pristanoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12947

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR VALTA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
type: Reaction
kinetic law: MODEL1310110021#
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: valine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_a89f24df_e94b_47a7_bf53_d7c01e304615
is encoded by: hsa:6576
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: SLC25A1
constant: false
is: D9HTE9
initial amount: NaN

metaR r2359
reactant: MODEL1310110021#
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaM h x
is: http://identifiers.org/pubchem.compound/3380
constant: false
is: C00080
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton

http://identifiers.org/biomodels.db/MODEL1310110021#_8127bd22_4d1f_4f32_884c_779c5e08b4c2
is: P48728
initial concentration: NaN
type: Species
name: AMT
has only substance units: false
initial amount: NaN
is encoded by: hsa:275
is: SBO:0000252
constant: false
boundary condition: true

metaM mag hs c
constant: false
type: Species
initial amount: NaN
is: CHEBI:16987
is: SBO:0000247
initial concentration: 1.0
name: monoacylglycerol 2
has only substance units: false
is: HMDB12130
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_55e01618_3260_4517_bfe2_81633f42716f
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: COX8C
is encoded by: hsa:341947
initial concentration: NaN
is: SBO:0000252
is: Q7Z4L0

http://identifiers.org/biomodels.db/MODEL1310110021#_b9eb13fd_5dba_46f8_a497_32353ed8b4e5
type: Species
name: _AI539321_1_c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:AI539321
boundary condition: true

metaM HC01434 m
constant: false
is: CHEBI:58931
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
name: oxalatosuccinate(3-)

http://identifiers.org/biomodels.db/MODEL1310110021#_50c3f89f_7d44_4bcc_b307_3bfd681863a3
name: _AV713053_1_m
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AV713053
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaM odecoa r
is: HMDB01322
is: SBO:0000247
is: CHEBI:57387
initial amount: NaN
constant: false
name: oleoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510

metaM HC02203 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
type: Species
is: CHEBI:27820
boundary condition: false
initial concentration: 1.0
constant: false
name: prostaglandin-a2
has only substance units: false
is: SBO:0000247

metaR r2084
kinetic law: MODEL1310110021#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_e6689af1_e52e_476a_aa9d_bf036cebb956
is encoded by: hsa:AI373818
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AI373818_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_1ea7f9b1_4251_423d_81eb_493663ff52f5
name: ASRGL1
initial concentration: NaN
is: Q7L266
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80150
boundary condition: true

metaR r0377
type: Reaction
fast: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110021#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is: SBO:0000176
kinetic law: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
product: MODEL1310110021#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f07cca3d_3ce1_41c7_b369_1dfd60e7f45d
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:8525
name: DGKZ
is: SBO:0000252
is: B7Z6M3
initial concentration: NaN
constant: false

metaR r1467
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
type: Reaction

metaM itacon m
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
constant: false
name: itaconate(2-)
initial concentration: 1.0
is: CHEBI:17240
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: HMDB02092

metaR MI14PP
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.3.57
is: SBO:0000176
fast: false
reactant: MODEL1310110021#
name: inositol-1,4-bisphosphate 1-phosphatase
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
kinetic law: MODEL1310110021#
reversible: false
is described by: ECO:0000269
type: Reaction
product: MODEL1310110021#

metaR FAOXC80
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110021#
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of med/long chain fatty acid

metaR r1302
name: Vesicular transport
is: SBO:0000185
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM 1p3h5c m
constant: false
is: HMDB01369
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
has only substance units: false
is: CHEBI:6151
initial concentration: 1.0
is: SBO:0000247

metaR r2083
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110021#

metaM HC01118 r
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57310
name: presqualene diphosphate(3-)

metaM citr L m
is: CHEBI:16349
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
boundary condition: false
type: Species
is: HMDB00904
has only substance units: false
is: SBO:0000247
name: L-citrulline

metaR SERPT
product: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110021#
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.50
type: Reaction
modifier: MODEL1310110021#
name: serine C-palmitoyltransferase

http://identifiers.org/biomodels.db/MODEL1310110021#_4371b148_7f3a_4d91_b2d9_3e945ba0705c
initial amount: NaN
is encoded by: hsa:84076
constant: false
name: TKTL2
type: Species
initial concentration: NaN
is: Q9H0I9
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_2463e3a7_3531_4baf_ab55_c68bbe84bd2a
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: BTD
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:686
is: P43251

metaM xol7ah c
initial concentration: 1.0
name: 7alpha-hydroxy-5beta-cholestan-3-one
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
type: Species
has only substance units: false
is: HMDB06892
constant: false
is: CHEBI:2290

metaM dgmp e
has only substance units: false
is: SBO:0000247
is: HMDB01044
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
type: Species
initial amount: NaN
name: dGMP(2-)
is: CHEBI:57673

metaM glc D c
constant: false
is: CHEBI:4167
is: SBO:0000247
initial concentration: 1.0
is: HMDB00122
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
name: D-glucose

http://identifiers.org/biomodels.db/MODEL1310110021#_7e9dff6a_ff05_48a9_9607_16f68d82e404
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: LDHAL6B
is encoded by: hsa:92483
is: Q9BYZ2
initial amount: NaN

metaM mag hs e
initial amount: NaN
is: HMDB03073
has only substance units: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:32391
name: monoacylglycerol 2

http://identifiers.org/biomodels.db/MODEL1310110021#_46d68612_a5bc_4dfd_af1d_f1a586e88679
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA419122
name: _AA419122_1_c

metaM gly c
is: C00037
is: SBO:0000247
initial amount: NaN
is: CHEBI:3339
is: HMDB00123
constant: false
type: Species
has only substance units: false
name: Glycine
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
boundary condition: false

metaR RE0830C
reversible: true
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
name: RE0830
fast: false
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#

metaR PItx
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: Phosphate transporter, peroxisome
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_002ed9cf_68ba_4662_abd4_bd22fb9dcddf
initial amount: NaN
name: PFKM
constant: false
has only substance units: false
is: SBO:0000252
is: P08237
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5213
type: Species

metaR r2354
reactant: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110021#_34dd4543_744c_44de_92df_53b554383721
has only substance units: false
is: O14732
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: IMPA2
initial concentration: NaN
is encoded by: hsa:3613

metaM ttdca e
has only substance units: false
name: tetradecanoate (n-C14:0)
type: Species
constant: false
boundary condition: false
is: HMDB00806
is: CHEBI:30807
is: C06424
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
initial amount: NaN
is: SBO:0000247

metaR ADRNCOAtx
reversible: true
is: SBO:0000185
product: MODEL1310110021#
name: fatty acid intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction

metaM so3 c
boundary condition: false
initial amount: NaN
is: C00094
name: Sulfite
constant: false
is: HMDB00240
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:17137
has only substance units: false

metaR r0226
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
modifier: MODEL1310110021#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false

metaM CE2422 m
boundary condition: false
is: HMDB11123
constant: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
type: Species
is: CHEBI:28387
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_ec412b4f_8fce_4525_9a61_977e49bb9cb1
constant: false
type: Species
has only substance units: false
is: SBO:0000252
name: HAO1
is: Q9UJM8
initial concentration: NaN
is encoded by: hsa:54363
initial amount: NaN
boundary condition: true

metaR FATP9t
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty acid electroneutral transport
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000185

metaR r1681
kinetic law: MODEL1310110021#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
modifier: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_733b1bb6_a05e_4e76_885a_24e771676f2c
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: ACSL6
is encoded by: hsa:23305
is: B2RB13
initial concentration: NaN
has only substance units: false

metaR DPCOAK
reactant: MODEL1310110021#
modifier: MODEL1310110021#
name: dephospho-CoA kinase
reversible: false
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.3
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false

metaR UROLACer
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
name: uronolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is: SBO:0000176
reversible: true

metaR r2355
fast: false
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#

metaR ORNt4m
reversible: true
fast: false
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
name: ornithine mitochondrial transport exchange with citruline
is described by: ECO:0000269
reactant: MODEL1310110021#
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000185

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR r2089
type: Reaction
is: SBO:0000185
modifier: MODEL1310110021#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM gly e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
is: CHEBI:3339
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB00123
type: Species
is: C00037
name: Glycine

metaR r1301
is described by: ECO:0000000
kinetic law: MODEL1310110021#
name: Vesicular transport
reactant: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110021#
type: Reaction

metaR r0002
reactant: MODEL1310110021#
name: Active transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_b47ab153_18ed_4992_b49d_5d275e8dce59
constant: false
name: GLUD2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2747
boundary condition: true
initial concentration: NaN
is: P49448
type: Species
has only substance units: false

metaR RE1531M
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1531
is: SBO:0000176
kinetic law: MODEL1310110021#

metaM pram c
is: CHEBI:58681
initial amount: NaN
boundary condition: false
is: HMDB01128
initial concentration: 1.0
has only substance units: false
name: 5-Phospho-beta-D-ribosylamine
is: SBO:0000247
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
constant: false
is: C03090
type: Species

metaR A MANASEly
product: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
is described by: ECO:0000000
name: alpha-mannosidase, lysosomal
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.24

metaR P450SCC1m
product: MODEL1310110021#
is described by: ECO:0000134
kinetic law: MODEL1310110021#
type: Reaction
reversible: true
fast: false
is: SBO:0000176
name: cholesterol monooxygenase
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

http://identifiers.org/biomodels.db/MODEL1310110021#_a7b8af0f_ee23_44a2_ad58_e64bf370d90c
is encoded by: hsa:286016
has only substance units: false
constant: false
initial concentration: NaN
name: TPI1P2
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

metaR r0706
modifier: MODEL1310110021#
reactant: MODEL1310110021#
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.10
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
kinetic law: MODEL1310110021#
reversible: false

metaR r2088
fast: false
reversible: true
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110021#
is: SBO:0000185

metaR r2356
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
reactant: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_9d59e304_117a_4a50_a1b8_3f60fdaece38
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: ACAD9
is: Q9H845
initial amount: NaN
has only substance units: false
is encoded by: hsa:28976

metaR MI145PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110021#
reversible: false
type: Reaction
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.36
name: inositol-1,4,5-trisphosphate 5-phosphatase
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86

metaM dtdp c
name: dTDP
initial concentration: 1.0
is: C00363
is: CHEBI:58369
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
is: SBO:0000247

metaR DURAD
name: dihydrouracil dehydrogenase (NADP)
modifier: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
reversible: true
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.2

http://identifiers.org/biomodels.db/MODEL1310110021#_4342a84a_5763_43ae_80ba_1b9c4ebe5427
name: CHAT
boundary condition: true
initial amount: NaN
is: D3DX95
has only substance units: false
is encoded by: hsa:1103
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

metaR ALR3
fast: false
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000176
reversible: false
name: aldose reductase (acetol)
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000269
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21

metaM omhpal c
is: HMDB06294
name: w-hydroxypalmiticacid
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C16H30O3 CHARGE: -1
initial amount: NaN
initial concentration: 1.0

metaM ttdca c
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB00806
is: CHEBI:30807
name: myristate
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
has only substance units: false

metaM hdd2coa x
initial amount: NaN
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61526
has only substance units: false
name: (E)-hexadec-2-enoyl-CoA(4-)
is: HMDB03945
type: Species

metaM ru5p D c
name: D-ribulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial amount: NaN
is: CHEBI:58121
constant: false
initial concentration: 1.0
type: Species
is: HMDB00618
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM ocdcea r
boundary condition: false
is: C00712
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
initial concentration: 1.0
is: CHEBI:0
is: SBO:0000247
constant: false
name: octadecenoate (n-C18:1)
is: HMDB00207
initial amount: NaN

metaM HC02217 c
is: CHEBI:27647
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: prostaglandin-g2

metaR SUCCt2m
is: SBO:0000185
product: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
name: succinate transport, mitochondrial
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110021#_11da06ff_747e_4c66_80b2_8d973a1485e6
type: Species
is encoded by: hsa:54898
boundary condition: true
initial amount: NaN
name: ELOVL2
is: SBO:0000252
has only substance units: false
is: Q9NXB9
initial concentration: NaN
constant: false

metaR FAOXC8C6m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_5a41cc7f_6f17_4494_8fb9_0404a3e02efa
is: P45954
is: SBO:0000252
is encoded by: hsa:36
constant: false
name: ACADSB
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true

metaR RE3251C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
kinetic law: MODEL1310110021#
reversible: false
fast: false
type: Reaction
is: SBO:0000176
name: RE3251
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR r1050
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110021#
type: Reaction
name: Vesicular transport
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:

metaM lnlccrn c
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial amount: NaN
initial concentration: 1.0
name: Linoleyl carnitine
boundary condition: false
is: HMDB06469
has only substance units: false

metaR THMPPtm
kinetic law: MODEL1310110021#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
name: Thiamine diphosphate transport in via anion antiport, mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT

metaR P4508B11r
is described by: ECO:0000269
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
modifier: MODEL1310110021#
name: sterol 12-alpha-hydroxylase
reversible: false
is: SBO:0000176
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.14.13.95
fast: false

metaR r2087
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110021#
reversible: true
is: SBO:0000185
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
fast: false

metaR r2357
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110021#
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110021#

metaR ALR2
type: Reaction
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21
name: aldose reductase (methylglyoxal)
reversible: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
product: MODEL1310110021#

metaR RE3269C
kinetic law: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110021#
type: Reaction
name: RE3269
is version of: http://identifiers.org/ec-code/3.1.3.48

http://identifiers.org/biomodels.db/MODEL1310110021#_336f66ec_51ae_4912_9e93_ae496ed753ef
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: DGUOK
initial concentration: NaN
type: Species
is encoded by: hsa:1716

metaR r1538
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110021#
product: MODEL1310110021#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is: SBO:0000185
fast: false
reactant: MODEL1310110021#
reversible: false

metaM dhcrm hs c
is: SBO:0000247
constant: false
name: dihydroceramide
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:31488
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
initial amount: NaN
initial concentration: 1.0

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR AKR1C41
is: SBO:0000176
type: Reaction
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
reactant: MODEL1310110021#
fast: false
reversible: false
product: MODEL1310110021#

metaR r1742
modifier: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_9d8f4429_77cf_4893_a94d_093bf7ce822f
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:50484
type: Species
is: Q7LG56
has only substance units: false
initial amount: NaN
boundary condition: true
name: RRM2B

metaR RAI1
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
name: retinal isomerase (11-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reversible: true
is: SBO:0000176
type: Reaction

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM dgsn m
is: SBO:0000247
boundary condition: false
name: Deoxyguanosine
type: Species
is: CHEBI:17172
is: HMDB00085
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330

metaR GLCt4
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000185
name: glucose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
product: MODEL1310110021#

metaR GLCt1r
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000269
name: glucose transport (uniport)
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR r1051
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false
name: Vesicular transport
type: Reaction
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110021#
is: SBO:0000185

metaR ACNMLr
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
reversible: true
fast: false
name: N-Acetylneuraminate lyase (reversible)
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110021#_e901d145_a062_4847_8bb1_9be01828fd78
is: O43772
type: Species
is encoded by: hsa:788
constant: false
initial amount: NaN
name: SLC25A20
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaM HC01522 c
is: CHEBI:28508
type: Species
has only substance units: false
name: Gentisate aldehyde
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM 42A3HP24DB c
is: C05645
is: SBO:0000247
is: HMDB04083
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
has only substance units: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: http://identifiers.org/pubchem.compound/7956

metaR r1685
fast: false
reactant: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
product: MODEL1310110021#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction

metaM arachd r
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
name: arachidonate
is: CHEBI:32395
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
has only substance units: false
is: HMDB01043
boundary condition: false

metaM 5thf e
is: HMDB06487
boundary condition: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
name: pentaglutamyl folate (THF)

http://identifiers.org/biomodels.db/MODEL1310110021#_e062e6cc_6fd2_468b_8a8e_2fd888779ac4
is encoded by: hsa:6472
boundary condition: true
initial amount: NaN
constant: false
is: B4DJQ3
initial concentration: NaN
is: SBO:0000252
name: SHMT2
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_23e0481a_260a_46d0_9353_feb01e61a36f
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AA614647_1_c
constant: false
is encoded by: hsa:AA614647
type: Species
initial amount: NaN
has only substance units: false

metaR ACNACNGALGBSIDEte
name: acnacngalgbside hs transport
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

http://identifiers.org/biomodels.db/MODEL1310110021#_7b10d0b6_14a4_40e9_b076_161fae80fcfb
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: E9PAK4
name: SLC5A9
boundary condition: true
type: Species
is encoded by: hsa:200010
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_07d11429_1983_4fba_974f_b9ba9bb2a919
initial amount: NaN
is encoded by: hsa:5315
type: Species
name: PKM2
has only substance units: false
is: P14618
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM Ssq23epx r
name: (S)-2,3-epoxysqualene
constant: false
is: SBO:0000247
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
initial amount: NaN
is: CHEBI:15441
type: Species
boundary condition: false
has only substance units: false
is: HMDB01188
initial concentration: 1.0

metaM CE5117 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial amount: NaN
is: CHEBI:57923
has only substance units: false
initial concentration: 1.0
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
is: SBO:0000247
type: Species
boundary condition: false
constant: false

metaM odecoa m
boundary condition: false
is: CHEBI:57387
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: SBO:0000247
initial amount: NaN
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
initial concentration: 1.0
has only substance units: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM nad c
is: C00003
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00902
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
has only substance units: false

metaR RE1526M
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
modifier: MODEL1310110021#
name: RE1526
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaM citr L c
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: L-citrulline
is: HMDB00904
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349

metaR r0156
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
reactant: MODEL1310110021#
type: Reaction
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is: SBO:0000176

metaR ITCOAL1m
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000304
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaM ura c
is: HMDB00300
is: SBO:0000247
initial concentration: 1.0
name: Uracil
is: CHEBI:17568
boundary condition: false
is: C00106
has only substance units: false
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
constant: false
initial amount: NaN

metaR GALt4
product: MODEL1310110021#
fast: false
is: SBO:0000185
modifier: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reversible: true
is described by: ECO:0000269
name: galactose transport via sodium symport
kinetic law: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_bc108483_6d34_41bc_a64c_74c1d8395047
initial amount: NaN
is: P07741
is: SBO:0000252
is encoded by: hsa:353
initial concentration: NaN
boundary condition: true
constant: false
name: APRT
has only substance units: false
type: Species

metaR r2110
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
reversible: true
reactant: MODEL1310110021#

metaM HC01712 m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
name: S-Glutaryldihydrolipoamide
constant: false
has only substance units: false
is: CHEBI:28391
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_66cc652c_0e86_42d4_9d4c_0d427c4b5dd8
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:D29675
has only substance units: false
name: _D29675_1_e
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_731eb600_eeed_47c3_a088_16e2504794f2
is: F8VQS7
name: NDUFA12
is encoded by: hsa:55967
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR r0157
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is version of: http://identifiers.org/ec-code/6.3.4.2
is: SBO:0000176
reactant: MODEL1310110021#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
fast: false
product: MODEL1310110021#

metaM HC00460 c
has only substance units: false
initial amount: NaN
name: 2,5-dihydroxybenzoate
boundary condition: false
type: Species
is: CHEBI:58044
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628

metaM acgal c
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: N-acetyl-D-galactosamine
initial concentration: 1.0
is: CHEBI:28037
type: Species
is: HMDB00212
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132

metaM HC02100 l
constant: false
name: Dihomo-gamma-linolenate
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:53486
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: SBO:0000247

metaR ACNACNGALGBSIDEtg
reactant: MODEL1310110021#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: acnacngalgbside hs intracellular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ

metaR RAI2
type: Reaction
name: retinal isomerase (9-cis)
kinetic law: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110021#
fast: false
is: SBO:0000176
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_3af7089c_54fb_480f_a71b_aa0bfb99c5d1
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6821
type: Species
initial amount: NaN
is: P51687
name: SUOX
is: SBO:0000252
boundary condition: true

metaM galgbside hs g
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
is: CHEBI:18259
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: galactosylgloboside

http://identifiers.org/biomodels.db/MODEL1310110021#_8e73d8a4_1504_41bf_88c2_59c3d67106c4
constant: false
initial amount: NaN
is encoded by: hsa:5313
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PKLR
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_60c33601_194b_42d0_a961_aa44419b67b9
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _83530_1_c
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:83530

metaR AFLATOXINte
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reversible: true
product: MODEL1310110021#
name: xenobiotic transport
is: SBO:0000185

metaM adp x
is: HMDB01341
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species
initial concentration: 1.0
name: ADP(3-)
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:456216

metaR r2111
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110021#
is: SBO:0000185

metaM ura e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00300
constant: false
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
name: uracil
has only substance units: false
is: CHEBI:17568
initial amount: NaN

metaR FAOXC184C163m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaR 5MTHFt2le
product: MODEL1310110021#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reactant: MODEL1310110021#
name: 5-methyltetrahydrofolate transport via anion exchange
kinetic law: MODEL1310110021#

metaM h n
is: CHEBI:24636
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
type: Species
name: proton
initial concentration: 1.0
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR GGH 5DHFl
reactant: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110021#
is: SBO:0000176
fast: false
name: Gamma-glutamyl hydrolase (5DHF), lysosomal
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reversible: false
type: Reaction
is described by: ECO:0000000

metaR HMGLx
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.1.3.4
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
name: hydroxymethylglutaryl-CoA lyase
modifier: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
fast: false

metaR DHPM1
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.2.2
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
name: dihydropyrimidinase (5,6-dihydrouracil)
fast: false
is described by: ECO:0000269
product: MODEL1310110021#
reversible: false

metaM citr L e
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00904
has only substance units: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349
initial concentration: 1.0
name: citr_L[e]

metaM retinol c
is: CHEBI:50211
is: SBO:0000247
initial concentration: 1.0
constant: false
name: retinol
has only substance units: false
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial amount: NaN
is: HMDB00305
boundary condition: false

metaR r0009
type: Reaction
is: SBO:0000176
modifier: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
fast: false
reversible: false

metaR OCDCEAtr
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_4e2dc8b7_6801_4a48_8d7c_0ad845ecc707
has only substance units: false
is: SBO:0000252
boundary condition: true
name: EARS2
initial amount: NaN
type: Species
is encoded by: hsa:124454
is: Q5JPH6
initial concentration: NaN
constant: false

metaR RE0830N
product: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
is: SBO:0000176
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE0830
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:

metaR r0812
modifier: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
reactant: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_35d842e1_4567_4373_8614_ff6b0f6c6342
type: Species
is: O15244
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: SLC22A2
is encoded by: hsa:6582

http://identifiers.org/biomodels.db/MODEL1310110021#_dc74355b_da0e_48dd_a8eb_e437fa553f08
initial concentration: NaN
name: ACOX1
constant: false
is: B4DK61
is encoded by: hsa:51
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM lgnc e
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:31014
name: lignocerate
initial amount: NaN
is: HMDB02003

metaM glc D e
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
constant: false
is: HMDB00122
initial concentration: 1.0
is: CHEBI:4167
boundary condition: false
type: Species
is: SBO:0000247
name: D-glucose

http://identifiers.org/biomodels.db/MODEL1310110021#_e3b5ce09_9f5e_4081_8f83_974363ab3fa2
initial amount: NaN
is encoded by: hsa:R14373
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: _R14373_1_x

metaM HC02203 e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: prostaglandin-a2
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
initial amount: NaN
has only substance units: false

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM dgmp c
is: CHEBI:57673
initial concentration: 1.0
constant: false
initial amount: NaN
is: C00362
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
type: Species
is: SBO:0000247
is: HMDB01044
boundary condition: false
has only substance units: false
name: dGMP

metaR ASNt4
is described by: ECO:0000269
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
is: SBO:0000185
product: MODEL1310110021#
name: L-asparagine transport in via sodium symport
reversible: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
type: Reaction

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaM hdd2coa m
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
has only substance units: false
name: trans-Hexadec-2-enoyl-CoA
initial concentration: 1.0
is: C05272
type: Species
boundary condition: false
is: CHEBI:61526
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB03945

metaM 4abutn c
is: C00555
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
type: Species
is: CHEBI:58264
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01080
name: 4-Aminobutanal
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR DGULND
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110021#
type: Reaction
name: dehydro-L-gulonate decarboxylase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD

metaR FAS100COA
product: MODEL1310110021#
reversible: false
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty acyl-CoA synthase (n-C10:0CoA)
is described by: ECO:0000269
modifier: MODEL1310110021#
type: Reaction

metaR GGH 5DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110021#
name: Gamma-glutamyl hydrolase (5DHF), extracellular
modifier: MODEL1310110021#
fast: false
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
is described by: ECO:0000000

metaR r1466
fast: false
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: EC:2.3.1.86
reactant: MODEL1310110021#

metaM HC02100 r
initial amount: NaN
constant: false
name: Dihomo-gamma-linolenate
is: CHEBI:53486
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0
is: SBO:0000247

metaM trdrd m
name: Reduced thioredoxin
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:15967

metaR LGTHL
modifier: MODEL1310110021#
is described by: ECO:0000269
fast: false
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
name: lactoylglutathione lyase
is version of: http://identifiers.org/ec-code/4.4.1.5
product: MODEL1310110021#
reversible: false
type: Reaction
kinetic law: MODEL1310110021#

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM adp r
is: CHEBI:456216
boundary condition: false
name: ADP(3-)
initial amount: NaN
is: HMDB01341
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR GLYtm
fast: false
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
name: glycine passive transport to mitochondria
is described by: ECO:0000000
reversible: true
product: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#

metaR ECOAH12m
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110021#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000304
is: SBO:0000176

metaM ump r
initial concentration: 1.0
name: UMP
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57865
is: HMDB00288
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species

metaM no e
initial concentration: 1.0
is: SBO:0000247
name: Nitric oxide
constant: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
has only substance units: false
is: HMDB03378
is: C00533
initial amount: NaN
type: Species
is: CHEBI:16480
boundary condition: false

metaR BHBt
is: SBO:0000185
name: (R)-3-Hydroxybutanoate transport via H+ symport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV

metaM gluala e
is: http://identifiers.org/pubchem.compound/6503
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: C03740
is: HMDB06248
type: Species
name: 5-L-Glutamyl-L-alanine
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: SBO:0000247

metaM trp L e
is: HMDB00929
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
name: L-tryptophan
is: SBO:0000247
initial amount: NaN
is: CHEBI:16828
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080

metaM 2ddecdicoa m
constant: false
name: 2,6-dodecadienoylcoa
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB11123
is: C05279
initial amount: NaN
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false

metaM ocdca c
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: CHEBI:25629
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00827
is: SBO:0000247
name: stearate

http://identifiers.org/biomodels.db/MODEL1310110021#_0cca9846_1130_4641_904c_c45f260e2ecf
initial concentration: NaN
is encoded by: hsa:2879
constant: false
has only substance units: false
name: GPX4
boundary condition: true
is: SBO:0000252
is: P36969
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_a00116b0_60ab_4981_92d0_6443b6e96edd
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:29922
has only substance units: false
name: NME7
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_f8c45913_9947_4425_8c25_b05b017157c6
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PLCZ1
is encoded by: hsa:89869
is: Q86YW0
initial concentration: NaN
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_15bd5974_4967_450f_b382_e997cb39d5af
constant: false
type: Species
is: P49327
has only substance units: false
name: FASN
initial concentration: NaN
is encoded by: hsa:2194
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_29e1c6c5_7de3_4b95_bf39_bc7ed6941f93
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:NOS2A
constant: false
name: _NOS2A_1_e

http://identifiers.org/biomodels.db/MODEL1310110021#_5676803c_593e_4de6_9695_b809adc9980c
name: _AA977580_1_c
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:AA977580
boundary condition: true

metaR RE3272N
is described by: ECO:0000000
is: SBO:0000176
name: RE3272
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
kinetic law: MODEL1310110021#
reversible: true
type: Reaction

metaM acgal1p c
constant: false
has only substance units: false
initial amount: NaN
is: HMDB06480
name: N-Acetyl-D-galactosamine 1-phosphate
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:55404

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM chlstol r
is: CHEBI:16290
is: HMDB06842
constant: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM lgnc c
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: CHEBI:31014
is: HMDB02003
name: lignocerate
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_f388e5b9_9ab0_45de_881b_360119f88a6d
initial concentration: NaN
constant: false
is: P26439
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:3284
name: HSD3B2
is: SBO:0000252

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_e92aef3a_37b8_466e_9e1a_c81839712bfc
name: IDH2
is encoded by: hsa:3418
is: P48735
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaR BAMPPALDOX
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is described by: ECO:0000212
reversible: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB

metaM CE1935 e
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB02329
name: spermine monoaldehyde
is: CHEBI:30623
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR FUMSO3tm
modifier: MODEL1310110021#
is described by: ECO:0000269
name: Fumarate:sulfite antiport, mitochondrial
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false

metaM h r
has only substance units: false
is: C00080
constant: false
is: CHEBI:24636
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: proton
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR r0892
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.27
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
name: Facilitated diffusion
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_e8a521d2_cac7_4158_a319_48101a18e67e
name: ATP2B4
is: P23634
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:493
type: Species

metaR FAOXC2051843m
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
modifier: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
reactant: MODEL1310110021#
is: SBO:0000176

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM arachd x
constant: false
is: CHEBI:32395
type: Species
is: SBO:0000247
is: HMDB01043
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM 4abutn e
initial amount: NaN
type: Species
is: CHEBI:58264
is: SBO:0000247
boundary condition: false
is: HMDB01080
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
constant: false
name: 4-ammoniobutanal

http://identifiers.org/biomodels.db/MODEL1310110021#_f6f1edab_a751_4c08_a4f0_d5d4198c3f98
is: P23434
initial concentration: NaN
name: GCSH
is: SBO:0000252
constant: false
is encoded by: hsa:2653
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaR AKR1C42
reversible: false
modifier: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
kinetic law: MODEL1310110021#
fast: false

metaR r1464
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Active transport
fast: false
is described by: ECO:0000000
reversible: true

metaM succoa x
is: SBO:0000247
is: HMDB01022
name: Succinyl-CoA
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5

metaR PSYGCHe
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaM nad e
constant: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: CHEBI:57540
initial concentration: 1.0
is: HMDB00902
boundary condition: false
name: NAD(1-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_81b9278f_ea63_4acb_8f54_281c57a8a88a
constant: false
name: _AI620219_1_e
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AI620219
type: Species
is: SBO:0000252

metaR DHORTS
type: Reaction
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.1.3.2
name: dihydroorotase
is: SBO:0000176
product: MODEL1310110021#
fast: false

metaM no c
name: Nitric oxide
is: CHEBI:16480
is: SBO:0000247
has only substance units: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
constant: false
is: HMDB03378
is: C00533
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_9743d566_82a9_4d48_af22_77b99f5fb9fc
boundary condition: true
constant: false
type: Species
is: Q8WUM9
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6574
name: SLC20A1

http://identifiers.org/biomodels.db/MODEL1310110021#_acf93b78_c5da_4ee3_b7fc_493c7f74a774
has only substance units: false
has part: P13804
initial concentration: NaN
is encoded by: hsa:2109
boundary condition: true
constant: false
type: Species
initial amount: NaN
name: ETFA:ETFB
is encoded by: hsa:2108
is: SBO:0000297

metaR ALDD2x
is described by: ECO:0000000
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110021#
name: aldehyde dehydrogenase (acetaldehyde, NAD)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110021#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
kinetic law: MODEL1310110021#

metaR r0813
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110021#
reversible: false
fast: false
product: MODEL1310110021#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
modifier: MODEL1310110021#

metaR PGDI
is described by: ECO:0000269
reactant: MODEL1310110021#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
name: Prostaglandin-H2 D-isomerase [Precursor]
reversible: true
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/5.3.99.2

metaM his L e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00177
initial amount: NaN
is: CHEBI:15971
name: L-histidine
boundary condition: false
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133

metaM udpgal c
is: HMDB00302
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58439
type: Species
name: UDP-D-galactose(2-)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

metaM 4hglusa m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: L-4-hydroxyglutamic semialdehyde
is: CHEBI:27809
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: HMDB06556

http://identifiers.org/biomodels.db/MODEL1310110021#_eb1c345b_1e53_4486_a1b0_789ff50e1fdc
boundary condition: true
name: AK5
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:26289
is: SBO:0000252
constant: false

metaR RE2974C
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
type: Reaction
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.149
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: RE2974

http://identifiers.org/biomodels.db/MODEL1310110021#_c27993a3_4a43_47d6_951f_c0abf738610c
is encoded by: hsa:65263
constant: false
initial amount: NaN
initial concentration: NaN
name: PYCRL
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is: Q53H96

http://identifiers.org/biomodels.db/MODEL1310110021#_938c7b87_42c9_4bcf_a135_a040deb68203
boundary condition: true
name: SLC2A13
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:114134
initial concentration: NaN
type: Species
is: Q96QE2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1c3e2b4d_718b_4776_a12c_c5a535dfec33
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AA177072
name: _AA177072_1_c

metaR r0817
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
reversible: true
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false

metaM 5adtststerones e
boundary condition: false
initial amount: NaN
is: HMDB06278
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_23a34ca9_49f6_46fd_b3a4_7c6996a6aa92
has only substance units: false
is: Q6IA69
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:55191
name: NADSYN1

metaR r0575
is: SBO:0000176
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
fast: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000000
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
product: MODEL1310110021#

metaR r2119
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
product: MODEL1310110021#
reversible: true
is: SBO:0000185
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_0fc0d6e7_fa8e_4e36_9cea_535aeecc57f8
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:55902
is: Q5QPH3
is: SBO:0000252
name: ACSS2
initial amount: NaN
has only substance units: false
constant: false

metaM nh4 c
is: CHEBI:28938
constant: false
type: Species
is: C01342
initial amount: NaN
initial concentration: 1.0
name: Ammonium
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_2add5cd8_60a0_45fd_8f29_53a9105c3441
is: SBO:0000252
type: Species
name: SLC23A1
boundary condition: true
is encoded by: hsa:9963
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_46177796_cd6e_4b00_b8f3_694b57490a4b
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10423
is: A8K3L7
initial amount: NaN
has only substance units: false
name: CDIPT

metaM Rtotal e
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
boundary condition: false
name: R total
type: Species
is: CHEBI:3554
constant: false
is: HMDB00244
has only substance units: false
is: C00255
initial concentration: 1.0

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM CE2432 m
is: CHEBI:57795
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
boundary condition: false

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM pmtcrn r
name: L-palmitoylcarnitine
is: SBO:0000247
is: HMDB00222
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_5786fc45_3cf9_4ae1_8cd7_e1a60f330783
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5052
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PRDX1

metaM gal c
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
is: CHEBI:0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: D-Galactose
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
is: C00124

metaR LEUKTRF4t
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110021#
name: leukotriene F4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
product: MODEL1310110021#

metaR RE1807C
is described by: ECO:0000000
name: RE1807
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110021#
fast: false
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaM h g
initial amount: NaN
constant: false
name: proton
has only substance units: false
is: CHEBI:24636
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR r0818
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
reversible: false
name: Transport reaction

metaR MMCDm
name: Methylmalonyl-CoA decarboxylase, mitochondrial
reversible: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/4.1.1.9
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_2cded156_6d6f_43f4_b907_487b4b3893ed
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: _FLJ44968_1_m
is encoded by: hsa:FLJ44968
has only substance units: false
boundary condition: true
type: Species

metaR r2118
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaM 12ppd S c
initial amount: NaN
initial concentration: 1.0
is: HMDB06213
has only substance units: false
name: (S)-propane-1,2-diol
constant: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: CHEBI:29002

metaR r0672
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110021#
product: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
fast: false
kinetic law: MODEL1310110021#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
type: Reaction
is: SBO:0000176

metaR VLCS2r
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
reversible: false
is described by: ECO:0000304
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_bfe97f1c_1ecc_48a3_a043_eae02b492c0f
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: A8K0S7
initial concentration: NaN
is encoded by: hsa:2542
name: SLC37A4
has only substance units: false
is: SBO:0000252

metaM succoa m
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: HMDB01022
type: Species
is: SBO:0000247
has only substance units: false
name: Succinyl-CoA
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57292
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_7342e640_1406_4ef5_a080_46313ee921f7
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: P27338
initial concentration: NaN
name: MAOB
is: SBO:0000252
is encoded by: hsa:4129
constant: false

metaM mhista c
name: N(tele)-methylhistaminium
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
initial amount: NaN
has only substance units: false
is: CHEBI:58600
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB00898
type: Species
is: SBO:0000247

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_0fb70a8e_ee96_4676_9e31_0b4da06ce3a3
initial concentration: NaN
is encoded by: hsa:AI620219
initial amount: NaN
type: Species
has only substance units: false
name: _AI620219_1_c
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_214848f8_cab8_437a_b2af_7772ad284647
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:7166
name: TPH1
is: P17752
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_a1e53d1c_a339_4c8a_ba4c_028da307696b
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: MTMR1
has only substance units: false
is encoded by: hsa:8776
is: Q13613
type: Species
constant: false
boundary condition: true

metaM tsul e
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: CHEBI:16094
is: HMDB00257
name: thiosulfate(2-)
boundary condition: false

metaM udpgal e
constant: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
is: CHEBI:58439
type: Species
is: SBO:0000247
has only substance units: false
name: UDP-D-galactose(2-)
boundary condition: false
is: HMDB00302

metaM grdp x
name: geranyl diphosphate(3-)
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:58057
constant: false
is: SBO:0000247
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: HMDB01285
initial amount: NaN

metaR DNDPt18m
is: SBO:0000185
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dUDP transport via ADP antiport
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110021#
fast: false
type: Reaction
product: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_d6f45103_e7a5_4ece_b9eb_bf64b48789c1
is encoded by: hsa:AA576959
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AA576959_1_c
type: Species
is: SBO:0000252
initial amount: NaN

metaM 5adtststerones c
is: HMDB06278
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
has only substance units: false

metaM Rtotal c
is: HMDB01448
notes: FORMULA: CO2FULLR CHARGE: -1
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: R total
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:16189

metaR r2117
modifier: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_518ec45b_1988_4e04_bc4b_a477100e129d
name: CYP2A13
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q16696
is encoded by: hsa:1553

metaM nh4 e
constant: false
initial amount: NaN
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: ammonium
initial concentration: 1.0
is: HMDB00051
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28938

http://identifiers.org/biomodels.db/MODEL1310110021#_477a2b9d_45d8_4bb0_add2_fba41c9cede7
name: GGH
boundary condition: true
is encoded by: hsa:8836
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: Q92820
constant: false
has only substance units: false

metaM thcholstoic r
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
is: HMDB03873
boundary condition: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247
is: CHEBI:18402

metaM thymd c
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: C00214
is: CHEBI:17748
is: SBO:0000247
name: Thymidine
is: HMDB00273

metaR RE2660N
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: RE2660
is described by: ECO:0000000
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_0df558ad_6cf0_4efc_a6c6_2c10dacdfe61
is: SBO:0000252
is encoded by: hsa:T83654
boundary condition: true
initial amount: NaN
name: _T83654_1_m
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR r1836
reversible: false
product: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false

metaM gal e
is: CHEBI:0
notes: FORMULA: C6H12O6 CHARGE: 0
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
is: HMDB00143
name: D-Galactose
initial amount: NaN
is: C00124
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_21f42414_45d2_49b6_b80c_8ae504aedda9
constant: false
name: VNN3:VNN2:VNN1
is: SBO:0000297
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:55350
initial concentration: NaN
initial amount: NaN

metaM glu5sa m
is: SBO:0000247
constant: false
is: HMDB02104
boundary condition: false
has only substance units: false
is: C01165
is: CHEBI:17232
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
name: L-Glutamate 5-semialdehyde
type: Species

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM dcsptn1crn m
is: HMDB06321
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
type: Species
constant: false

metaR r0670
type: Reaction
is: SBO:0000176
product: MODEL1310110021#
reversible: false
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false

metaR r2116
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_65ade592_1e79_405b_9d74_d03d0f8601d6
type: Species
is encoded by: hsa:3033
boundary condition: true
name: HADH
constant: false
is: Q16836
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM lnlccoa c
type: Species
is: HMDB01064
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
is: SBO:0000247
has only substance units: false
name: linoleic coenzyme A
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_7b2e95c1_59bc_4d26_8ecc_14e4862c194f
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:80025
initial amount: NaN
name: PANK2
has only substance units: false
constant: false

metaM ocdca e
is: HMDB00827
is: CHEBI:25629
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
has only substance units: false
initial amount: NaN
is: C01530
name: octadecanoate (n-C18:0)
constant: false
initial concentration: 1.0

metaM udpgal g
is: CHEBI:58439
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00302
type: Species
is: SBO:0000247
name: UDP-D-galactose(2-)
has only substance units: false
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052

metaM 4hpro LT e
is: HMDB00725
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: trans-4-hydroxy-L-proline
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1

metaR SUCCTD
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_f76fcc6c_30ad_4f24_bbbc_a6d7b780904e
name: DUT
initial concentration: NaN
is: P33316
is encoded by: hsa:1854
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_30e7773f_d679_469b_8425_81e48cbea163
name: NT5E
is encoded by: hsa:4907
type: Species
boundary condition: true
is: P21589
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r0579
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is version of: http://identifiers.org/ec-code/1.13.11.19
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110021#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
product: MODEL1310110021#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_c7d7f8ef_b230_46fc_a78b_fa6648da5995
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7372
initial amount: NaN
is: A8K5J1
type: Species
boundary condition: true
name: UMPS
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_ca69e927_f2a8_498d_976f_2a9e4e0e8329
name: SLC22A1
is encoded by: hsa:6580
has only substance units: false
type: Species
initial concentration: NaN
is: O15245
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR NCNt
modifier: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reversible: true
reactant: MODEL1310110021#
name: Na+/Ca2+-NH4+ exchange

http://identifiers.org/biomodels.db/MODEL1310110021#_3220c2c5_7590_4f1c_aa7d_6719fe935a3a
has only substance units: false
initial concentration: NaN
constant: false
is: P04075
type: Species
name: ALDOA
initial amount: NaN
is encoded by: hsa:226
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_9f66b49a_d4ba_4ad1_8ccc_75217e3c46c8
is encoded by: hsa:37
boundary condition: true
name: ACADVL
is: P49748
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_3b6f4cdf_3fd8_4882_bec7_899a97dfa00a
constant: false
type: Species
is encoded by: hsa:4830
boundary condition: true
is: SBO:0000297
name: NME1:NME2
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM nad m
name: Nicotinamide adenine dinucleotide
initial amount: NaN
initial concentration: 1.0
is: HMDB00902
is: C00003
constant: false
boundary condition: false
type: Species
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
is: SBO:0000247

metaR CYANtm
is described by: ECO:0000000
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
fast: false
name: Cyanide transport via diffusion (mitochondrial)
reversible: true
reactant: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#

metaR FAOXC164C165m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM man1p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: HMDB06330
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: D-Mannose 1-phosphate
is: CHEBI:35374
initial amount: NaN

metaR TCHOLAte
product: MODEL1310110021#
name: bile acid intracellular transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
fast: false
kinetic law: MODEL1310110021#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_d1e000c9_40d7_4f97_98c4_286b07e654b6
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: Q9NVE7
type: Species
initial concentration: NaN
name: PANK4
is encoded by: hsa:55229
is: SBO:0000252

metaR r2115
is described by: ECO:0000000
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_921d03d7_db53_4f4f_ab61_48dd8663948e
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q53XN1
is encoded by: hsa:1351
initial amount: NaN
is: SBO:0000252
name: COX8A

metaR r0578
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.1.2.27
is described by: ECO:0000000
kinetic law: MODEL1310110021#

metaR FORMCOAtx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: formyl coa transport

http://identifiers.org/biomodels.db/MODEL1310110021#_f139ffa9_f92e_4ae1_a98d_22b0cf9ac671
is: G5E960
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5331
name: PLCB3

http://identifiers.org/biomodels.db/MODEL1310110021#_0c6220a9_c790_4518_b31a_2fc8d6fdc068
is encoded by: hsa:60386
constant: false
has only substance units: false
is: Q9HC21
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: SLC25A19
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_3ab472ff_1b8a_4acf_af89_d186e92579f5
is encoded by: hsa:5289
initial amount: NaN
constant: false
has only substance units: false
is: Q8NEB9
type: Species
name: PIK3C3
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_fd656892_4128_4f65_9669_ef01956c8234
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: CRLS1
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:54675
is: Q9UJA2

http://identifiers.org/biomodels.db/MODEL1310110021#_ab6016eb_d5ca_4710_988e_e4d0a313560d
initial amount: NaN
initial concentration: NaN
is: O95169
boundary condition: true
is: SBO:0000252
name: NDUFB8
type: Species
has only substance units: false
constant: false
is encoded by: hsa:4714

http://identifiers.org/biomodels.db/MODEL1310110021#_a32ad9c2_aa54_49f6_a9df_06a0c9fbf62c
name: ALDOA
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:226
boundary condition: true
constant: false
is: SBO:0000252
type: Species

metaR PPDOy
reversible: false
is: SBO:0000176
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110021#
product: MODEL1310110021#

metaM strdnc l
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
type: Species
name: stearidonic acid C18:4, n-3
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205608
is: HMDB06547
is: SBO:0000247
is: C16300
initial amount: NaN

metaR HIBDm
is version of: http://identifiers.org/ec-code/1.1.1.31
product: MODEL1310110021#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
fast: false
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
reactant: MODEL1310110021#

metaR KCC2t
is described by: ECO:0000269
fast: false
name: K+-Cl- cotransporter (NH4+)
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_95133f7f_3099_4ef7_a812_bf0e9a825800
name: MPI
constant: false
boundary condition: true
is: P34949
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4351
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_b60d0ffe_a7f7_4fb0_9672_d4d479bbe758
initial concentration: NaN
has only substance units: false
name: COX7C
is: P15954
is encoded by: hsa:1350
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR SBTR
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
fast: false
reversible: false
product: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
modifier: MODEL1310110021#
name: D-sorbitol reductase
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110021#

metaR r2114
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110021#

metaR r0819
modifier: MODEL1310110021#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false

metaR RE1519M
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
name: RE1519
reactant: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#

metaR r2113
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110021#
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM 6dhf e
constant: false
is: HMDB06563
has only substance units: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
initial concentration: 1.0
name: hexaglutamyl folate (DHF)
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN

metaM h l
boundary condition: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
name: proton
type: Species
initial concentration: 1.0
is: C00080
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
constant: false

metaR 5ADTSTSTERONEtr
type: Reaction
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
name: 5 alpha dihydrotesterone intracellular transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_4b7bbfc0_2251_4591_bf99_09d3df2d7529
name: NDUFA6
constant: false
initial amount: NaN
boundary condition: true
is: P56556
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4700
is: SBO:0000252

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_72d789f9_5412_498e_8301_3c20fe952b7c
boundary condition: true
is encoded by: hsa:594
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: P21953
is: SBO:0000252
name: BCKDHB

metaM gtp c
is: HMDB01273
name: GTP
boundary condition: false
is: C00044
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:37565
constant: false

metaR GGH 10FTHF6GLUe
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110021#
reactant: MODEL1310110021#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is: SBO:0000176
kinetic law: MODEL1310110021#

metaM 3octdectecoa m
constant: false
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: 3,6,9,12-octadecatetraenoylcoa
is: HMDB06294
initial concentration: 1.0

metaR r2112
type: Reaction
fast: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaR RE2069C
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110021#
name: RE2069
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#

metaR SGPL12r
is version of: http://identifiers.org/ec-code/4.1.2.27
name: Sphingosine-1-phosphate lyase
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
is described by: ECO:0000304
product: MODEL1310110021#
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
modifier: MODEL1310110021#

metaR DOLPMT4 Ler
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
is: SBO:0000185

metaR CAATPS
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
kinetic law: MODEL1310110021#
is: SBO:0000185
name: Ca ATPase
type: Reaction
modifier: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.8

metaM h m
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: C00080
is: CHEBI:24636
name: proton

metaM thp2c c
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: CHEBI:16987
boundary condition: false
name: 1-piperideine-6-carboxylate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB12130
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_80bf6d41_9a04_4e10_bf5c_a8ce12028c27
is: P22352
boundary condition: true
initial amount: NaN
name: GPX3
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2878
initial concentration: NaN
type: Species
constant: false

metaR VLCS2p
reversible: false
is described by: ECO:0000304
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
type: Reaction
fast: false
product: MODEL1310110021#
name: Very-long-chain-fatty-acid-CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176

metaR FRDPtcr
kinetic law: MODEL1310110021#
is described by: ECO:0000134
type: Reaction
reversible: true
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is: SBO:0000185

metaM thcholstoic m
boundary condition: false
constant: false
is: HMDB03873
type: Species
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR G6PDH1rer
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
reversible: true
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.47
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
kinetic law: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
type: Reaction

metaM h2o2 x
is: HMDB03125
initial concentration: 1.0
is: CHEBI:16240
initial amount: NaN
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: SBO:0000247
name: Hydrogen peroxide
has only substance units: false
boundary condition: false
type: Species

metaM fadh2 r
has only substance units: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01197
is: SBO:0000247
is: CHEBI:58307
initial concentration: 1.0
name: FADH2(2-)
constant: false

metaR THBPT4ACAMDASE
type: Reaction
fast: false
kinetic law: MODEL1310110021#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
modifier: MODEL1310110021#
product: MODEL1310110021#

metaM trdrd c
has only substance units: false
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
is: CHEBI:15967
boundary condition: false
initial amount: NaN
is: C00342
initial concentration: 1.0
name: Reduced thioredoxin
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_bcae8cca_e25b_4505_93d3_45dfdf8dad0f
is encoded by: hsa:1593
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q02318
name: CYP27A1
boundary condition: true
constant: false
initial amount: NaN

metaR GULN3D
kinetic law: MODEL1310110021#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
name: L-gulonate 3-dehydrogenase
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_b55543a7_a2d7_4006_b7b8_9852a0edbcd4
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:100
boundary condition: true
initial concentration: NaN
constant: false
name: ADA
is: P00813
has only substance units: false

metaR GCC2am
is: SBO:0000176
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
product: MODEL1310110021#
name: glycine-cleavage complex (lipoamide), mitochondrial
reversible: true

metaR THFtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000185
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial

metaR HEXDICOAACBPx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaM gal l
name: D-galactose
type: Species
is: HMDB00143
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124

http://identifiers.org/biomodels.db/MODEL1310110021#_73a5998a_ccee_4239_bec5_1d5e8e2aa01f
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:10587
name: TXNRD2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_db00a65a_c1ed_48b2_921e_a0755cbdc9e5
name: EHHADH
is encoded by: hsa:1962
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is: Q9NY65
is: SBO:0000252
initial amount: NaN

metaR GLNtm
product: MODEL1310110021#
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110021#
name: L-glutamine transport via electroneutral transporter
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_ef07865b_f76b_4938_839b_db5f36abc92a
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:6888
name: TALDO1
has only substance units: false
boundary condition: true
is: P37837

metaR HAS2
reactant: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase
reversible: false
kinetic law: MODEL1310110021#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
modifier: MODEL1310110021#

metaM 6a2ohxnt x
has only substance units: false
is: HMDB12151
is: SBO:0000247
boundary condition: false
is: CHEBI:17534
initial concentration: 1.0
constant: false
name: 6-amino-2-oxohexanoic acid
type: Species
initial amount: NaN
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239

metaR r2353
is: SBO:0000185
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
type: Reaction
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#

metaR NDPK5n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
kinetic law: MODEL1310110021#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
fast: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110021#
reversible: true

metaR r0784
product: MODEL1310110021#
fast: false
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
reactant: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
kinetic law: MODEL1310110021#

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR PYRt2r
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
name: pyruvate reversible transport via proton symport
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
fast: false
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e391f5a3_a7f4_43a5_bf31_3c3ffc6f1dae
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ACAA1
is: Q96CA6
type: Species
constant: false
is encoded by: hsa:30

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR ILEt5m
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110021#
name: Isoleucine mitochondrial transport

metaM o2s m
is: C00704
boundary condition: false
is: SBO:0000247
constant: false
name: Superoxide anion
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
is: HMDB02168
is: CHEBI:18421
type: Species
initial concentration: 1.0
has only substance units: false

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR DNDPt25m
kinetic law: MODEL1310110021#
is: SBO:0000185
fast: false
name: dTDP transport via dCDP antiport
is described by: ECO:0000269
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
modifier: MODEL1310110021#
reversible: false
product: MODEL1310110021#

metaR DCK2n
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is version of: http://identifiers.org/ec-code/2.7.1.74
reactant: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000176
fast: false
name: Deoxycytidine kinase, nuclear (UTP)
is described by: ECO:0000269
type: Reaction

metaM 7thf e
is: SBO:0000247
name: heptaglutamyl folate (THF)
has only substance units: false
type: Species
is: HMDB06559
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C49H57N13O24 CHARGE: -8

http://identifiers.org/biomodels.db/MODEL1310110021#_34431325_f064_4f20_997f_6909c61bcd13
initial concentration: NaN
type: Species
is encoded by: hsa:759
is: P00915
initial amount: NaN
name: CA1
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_df62db6f_4516_42ad_8369_ac80c714ed62
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: E9PB82
is encoded by: hsa:3295
type: Species
name: HSD17B4
is: SBO:0000252

metaR FACOAL204
reversible: true
modifier: MODEL1310110021#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_1900e355_1290_4193_aca9_cab2e1679155
name: LDHB
initial concentration: NaN
is: P07195
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:3945
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_56600c01_a6ca_405e_9c69_ad050b1a7e47
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:3948
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: LDHC

metaR r2352
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110021#

metaM udpg c
initial concentration: 1.0
is: C00029
name: UDPglucose
is: HMDB00286
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: CHEBI:58367

http://identifiers.org/biomodels.db/MODEL1310110021#_bb5e2274_b8b1_47f6_87fa_1cba9a6db246
has only substance units: false
name: PTS
is: Q03393
boundary condition: true
constant: false
is encoded by: hsa:5805
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR NACHEX27ly
is described by: ECO:0000269
kinetic law: MODEL1310110021#
fast: false
product: MODEL1310110021#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110021#

metaR HMGCOAtx
product: MODEL1310110021#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport

metaR RE1807M
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
name: RE1807
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176

metaR URIt4
is described by: ECO:0000269
reactant: MODEL1310110021#
name: uridine transport in via sodium symport
modifier: MODEL1310110021#
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_b9dec598_c084_49c4_906b_17653db698ac
is encoded by: hsa:H17063
constant: false
boundary condition: true
is: SBO:0000252
type: Species
name: _H17063_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM h2o2 m
is: SBO:0000247
initial amount: NaN
is: HMDB03125
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16240
is: C00027
name: Hydrogen peroxide
initial concentration: 1.0

metaM nh4 m
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
initial concentration: 1.0
is: CHEBI:28938
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: Ammonium

metaR THMDt5le
modifier: MODEL1310110021#
name: thymidine transport (1:2 Na/Thymd cotransport)
product: MODEL1310110021#
type: Reaction
fast: false
is described by: ECO:0000134
reactant: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX adprib LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ADPribose exchange
type: Reaction

metaM nh4 n
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
is: CHEBI:28938
is: HMDB00051
name: ammonium
has only substance units: false
initial concentration: 1.0
constant: false

metaR RE0935E
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110021#
product: MODEL1310110021#
name: RE0935
fast: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction

metaM lnlccoa m
constant: false
has only substance units: false
is: HMDB01064
name: linoleic coenzyme A
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
boundary condition: false
initial amount: NaN

metaR PNTEH
reactant: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000269
name: Hydrolase Class ( RXN R02973)
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
is version of: http://identifiers.org/ec-code/3.5.1.92

metaR PE HStm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110021#
reversible: true
type: Reaction
kinetic law: MODEL1310110021#

metaM nrvnc c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB02368
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:32392
constant: false
name: nervonate

metaR NADS2
reactant: MODEL1310110021#
reversible: false
name: NAD synthase (glutamine-hydrolysing)
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.3.5.1
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_524d590e_3e17_43ed_8c46_14c92dba9223
is encoded by: hsa:5092
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: PCBD1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_94f488f0_5b82_4dfc_90a5_376aa211f9b2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: INPP1
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:3628
has only substance units: false
is: P49441

http://identifiers.org/biomodels.db/MODEL1310110021#_fddd2eaf_60bf_489e_8fcc_67eab2e831b9
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:51205
boundary condition: true
name: ACP6
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9NPH0

http://identifiers.org/biomodels.db/MODEL1310110021#_f9477ee7_1602_4eac_b9f4_1106bbf26d26
is: SBO:0000252
is encoded by: hsa:9962
initial concentration: NaN
constant: false
name: SLC23A2
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true

metaM nad r
initial amount: NaN
constant: false
name: NAD(1-)
type: Species
is: CHEBI:57540
boundary condition: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: HMDB00902
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_e59e19af_5000_46d9_9a6d_e69a804b5888
initial concentration: NaN
type: Species
is encoded by: hsa:6240
is: SBO:0000252
constant: false
name: RRM1
is: P23921
boundary condition: true
initial amount: NaN
has only substance units: false

metaR CHOLK
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: Choline kinase
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110021#
type: Reaction
reversible: false
modifier: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.32

http://identifiers.org/biomodels.db/MODEL1310110021#_023676c0_07d6_4ca3_833a_a1ac19e8200d
has only substance units: false
is encoded by: hsa:5213
initial concentration: NaN
boundary condition: true
is: SBO:0000297
initial amount: NaN
has part: P08237
type: Species
name: PFKM:PFKP
constant: false

metaR RE3628M
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
name: RE3628
kinetic law: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaM zym int2 r
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:52386
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
name: zymosterol intermediate 2

metaR r2090
reversible: true
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR FACOAL206
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_5fcc1808_1314_4089_907d_65070e2afde4
type: Species
boundary condition: true
is encoded by: hsa:10870
constant: false
has only substance units: false
name: HCST:PIK3CG
is: SBO:0000297
has part: Q9UBK5
has part: P48736
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5294

metaR r0783
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
product: MODEL1310110021#
is: SBO:0000176
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72

metaR GLYCtm
is: SBO:0000185
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: true
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
name: glycerol transport
fast: false

metaM pmtcrn x
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:17490
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
name: L-palmitoylcarnitine
initial amount: NaN
boundary condition: false
constant: false

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

metaM dolglcp L r
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:15812
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial concentration: 1.0

metaM 6dhf l
name: hexaglutamyl folate (DHF)
initial amount: NaN
type: Species
is: HMDB06563
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
boundary condition: false

metaR GLYt2r
is described by: ECO:0000304
name: glycine reversible transport via proton symport
is: SBO:0000185
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
type: Reaction

metaR r0780
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reactant: MODEL1310110021#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
kinetic law: MODEL1310110021#
fast: false
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000176

metaR CLFORtex
fast: false
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
name: chloride transport via formate countertransport
is described by: ECO:0000304
reactant: MODEL1310110021#
reversible: false

metaM fadh2 m
is: C01352
is: HMDB01197
type: Species
name: Flavin adenine dinucleotide reduced
has only substance units: false
boundary condition: false
is: CHEBI:58307
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352

metaR BTNt4i
product: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
modifier: MODEL1310110021#
fast: false
name: Biotin uptake (antiport)
is: SBO:0000185
reversible: false
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaR MCLOR
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
fast: false
product: MODEL1310110021#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
name: 3-Mercaptolactate:NAD+ oxidoreductase
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction

metaR CYTK11
reactant: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
modifier: MODEL1310110021#
name: cytidylate kinase (dCMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110021#

metaR DITPtn
type: Reaction
is: SBO:0000185
name: dITP nuclear transport
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110021#

metaR UDPG4E
name: UDPglucose 4-epimerase
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.2
fast: false
product: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
type: Reaction

metaM nrvnc e
boundary condition: false
constant: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB02368
name: nervonate
type: Species
is: CHEBI:32392

metaR r0926
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
type: Reaction
product: MODEL1310110021#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_f285df06_d3e2_4f88_b0c0_269c68ed3231
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9BZ23
name: PANK2
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:80025

metaR GGH 7THFe
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
reversible: false
name: Gamma-glutamyl hydrolase (7THF), extracellular
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110021#_47283a1d_7dff_46f6_8bb3_b6a5b83643b8
constant: false
boundary condition: true
is: SBO:0000297
name: NME1:NME2
type: Species
initial concentration: NaN
is encoded by: hsa:4830
initial amount: NaN
has only substance units: false

metaR CYTK7n
modifier: MODEL1310110021#
name: cytidylate kinase (CMP,UTP),nuclear
fast: false
is: SBO:0000176
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110021#

metaM gtp n
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
constant: false
initial amount: NaN
name: GTP(4-)
boundary condition: false
is: SBO:0000247
is: HMDB01273
has only substance units: false
is: CHEBI:37565
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_daf55603_9dc6_4763_8d47_439e8fff374d
is: SBO:0000252
constant: false
is encoded by: hsa:641649
boundary condition: true
has only substance units: false
name: TMEM91
initial concentration: NaN
type: Species
initial amount: NaN
is: C9JZ62

metaR PI5P4K
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.67
product: MODEL1310110021#
name: phosphatidylinositol-5-phosphate 4-kinase
notes: GENE_ASSOCIATION: (5297.1) or (55361.1) or (5298.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.149 Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9211928,PMID:9367159 NOTES:NCD
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#

metaR r2091
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110021#
fast: false
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM tsul c
constant: false
boundary condition: false
is: CHEBI:16094
name: thiosulfate(2-)
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00257
initial concentration: 1.0

metaR ACALDt
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
name: acetaldehyde reversible transport
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110021#
type: Reaction

metaM CE2839 e
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
boundary condition: false
name: maltodecaose
is: SBO:0000247
type: Species
initial amount: NaN
is: C01936
constant: false

metaR FAOXC16BRx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR PROSTGD2t
reactant: MODEL1310110021#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110021#

metaR r0570
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.3.3.2
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_a60a3309_e47f_4420_8c8b_1bb98cf1f4a7
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:AI697028
boundary condition: true
name: _AI697028_1_e
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_78ae1e28_70d8_4a42_825b_625c9577bab0
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM lald L c
is: SBO:0000247
name: (S)-lactaldehyde
is: HMDB03052
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:18041

metaR RE2349C
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
fast: false
name: RE2349
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
kinetic law: MODEL1310110021#

metaM CE2416 x
initial concentration: 1.0
name: (2R,6S,10S)-pristanate
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:57923
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)/p-1/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: CE2416

metaR CYTK12
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000176
fast: false
name: cytidylate kinase (dCMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR FOLR2
kinetic law: MODEL1310110021#
reversible: false
product: MODEL1310110021#
reactant: MODEL1310110021#
name: folate reductase
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110021#
is: SBO:0000176

metaR r1318
reversible: true
reactant: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_dbfc423b_8be3_47cd_9da6_84256e378f9f
name: OCRL
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:4952
initial concentration: NaN
initial amount: NaN
constant: false

metaR FAOXC164C143m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaR r0781
modifier: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176
product: MODEL1310110021#

metaR PYRt2m
type: Reaction
fast: false
name: pyruvate mitochondrial transport via proton symport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000

metaM ptrc e
name: Putrescine
boundary condition: false
is: HMDB01414
initial amount: NaN
is: C00134
has only substance units: false
is: CHEBI:326268
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134

metaM h c
initial concentration: 1.0
is: C00080
is: CHEBI:24636
boundary condition: false
has only substance units: false
constant: false
name: proton
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
is: SBO:0000247
type: Species

metaM maltpt e
is: SBO:0000247
is: C02052
type: Species
is: HMDB01296
boundary condition: false
initial concentration: 1.0
name: maltopentaose
has only substance units: false
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: http://identifiers.org/pubchem.compound/5141
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_a18bd8c7_95e2_4f31_9f3c_aafa45dd7f1b
name: PMVK
has only substance units: false
is: SBO:0000252
is: Q6FGV9
boundary condition: true
is encoded by: hsa:10654
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_39e9f2fd_af79_4c43_9115_f22bab45f4a3
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:39
name: ACAT2
boundary condition: true
is: Q9BWD1
has only substance units: false

metaM thcholstoic x
type: Species
is: HMDB03873
initial concentration: 1.0
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247

metaM CE1926 e
type: Species
initial amount: NaN
is: HMDB00127
initial concentration: 1.0
name: gama-carboxyethyl-hydroxychroman
is: SBO:0000247
is: CHEBI:15748
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
boundary condition: false
has only substance units: false
constant: false

metaR UMPK7n
kinetic law: MODEL1310110021#
name: UMP kinase (dGTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110021#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000269

metaR r2092
fast: false
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110021#

metaM dgtp n
type: Species
initial concentration: 1.0
is: C00286
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB01440
name: dGTP
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
is: CHEBI:16497

metaM gtp m
boundary condition: false
is: HMDB01273
has only substance units: false
type: Species
is: C00044
constant: false
initial amount: NaN
is: CHEBI:37565
name: GTP
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247

metaR OROTGLUt
name: OROTGLUt
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000134
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaM hexe3coa m
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06522
constant: false
initial concentration: 1.0
is: SBO:0000247
name: 3-hexenoylcoa

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR GLCURter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
product: MODEL1310110021#
is described by: ECO:0000000
fast: false
name: glucuronate endoplasmic reticular transport
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#

metaR RE3079X
product: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
is described by: ECO:0000000
fast: false
name: RE3079
reactant: MODEL1310110021#
type: Reaction

metaR TTDCAtr
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
name: tetradecanoate (transport)
product: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#

metaR r0464
fast: false
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110021#
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
kinetic law: MODEL1310110021#

metaR r2012
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
type: Reaction
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_b738cb92_1ebd_4ed1_a453_549c87cfe55c
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:3074
name: HEXB
is: P07686
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR MANtly
product: MODEL1310110021#
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
name: mannose efflux from lysosome
is: SBO:0000185

metaM nad x
type: Species
initial concentration: 1.0
is: HMDB00902
is: CHEBI:57540
has only substance units: false
name: Nicotinamide adenine dinucleotide
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
is: SBO:0000247
constant: false
is: C00003

metaR MI145PK
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.127
fast: false
is described by: ECO:0000269
name: inositol-1,4,5-trisphosphate 3-kinase
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaR r2093
reversible: true
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM dgtp m
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: C00286
is: HMDB01440
initial amount: NaN
has only substance units: false
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
initial concentration: 1.0

metaR G5SADrm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
product: MODEL1310110021#
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110021#
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_c74fedc6_2172_4b9c_b4ab_fdae59d4a205
is encoded by: hsa:125061
name: AFMID
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q63HM1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_bd119e42_7a62_410d_be81_86ad25f880f0
constant: false
boundary condition: true
type: Species
has only substance units: false
is: P24752
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:38
name: ACAT1

metaM apoC Lys btn m
is: C05552
initial amount: NaN
type: Species
is: HMDB03134
has only substance units: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
boundary condition: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
is: SBO:0000247
constant: false

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM strdnc r
constant: false
is: HMDB06547
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: SBO:0000247
is: C16300
is: http://identifiers.org/pubchem.compound/47205608
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
name: stearidonic acid C18:4, n-3

metaR FACOAL181i
is: SBO:0000176
type: Reaction
name: C181 fatty acid activation
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110021#
reversible: false
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is described by: ECO:0000269
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR GLYBt4 2 r
reactant: MODEL1310110021#
name: Betaine transport (sodium symport) (2:1)
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
is described by: ECO:0000269

metaR RE0691C
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
name: RE0691
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#

metaM 6dhf m
type: Species
constant: false
is: SBO:0000247
is: HMDB06563
has only substance units: false
name: hexaglutamyl folate (DHF)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_4c2845e3_5394_4766_bc24_d0dc20cf8fe1
boundary condition: true
type: Species
name: _LOC374569_1_e
initial concentration: NaN
is encoded by: hsa:LOC374569
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_536949ca_f64e_4616_a8f0_2b4ab9cc8c46
type: Species
is: Q6IBB5
has only substance units: false
initial amount: NaN
name: NDUFA1
is: SBO:0000252
is encoded by: hsa:4694
initial concentration: NaN
boundary condition: true
constant: false

metaR CYTK13n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110021#
fast: false
product: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dATP),nuclear
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000269

metaR FAOXC163Gm
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaR PHYCBOXL
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.28
reversible: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
name: L-Phenylalanine carboxy-lyase
is: SBO:0000176
reactant: MODEL1310110021#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB

metaM sphmyln hs g
is: CHEBI:58216
name: sphingomyelin betaine
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_d4c2b6a6_a4bf_47eb_a74d_2ff00e5a24e8
is encoded by: hsa:R33828
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: _R33828_1_c

metaR DPCOAPPe
reactant: MODEL1310110021#
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
name: Pyrophasphatase (dephospho-CoA, extracellular)
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR ALAt2r
fast: false
is: SBO:0000185
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110021#
name: L-alanine reversible transport via proton symport
modifier: MODEL1310110021#
product: MODEL1310110021#
reversible: true
type: Reaction
kinetic law: MODEL1310110021#

metaR r0463
is described by: ECO:0000000
product: MODEL1310110021#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM h e
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
type: Species
name: proton
is: CHEBI:24636
initial amount: NaN
constant: false
boundary condition: false

metaR r1832
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110021#
is described by: ECO:0000000
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR PYK
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
name: pyruvate kinase
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40

metaM ptrc c
constant: false
boundary condition: false
has only substance units: false
is: HMDB01414
initial concentration: 1.0
is: C00134
initial amount: NaN
is: CHEBI:326268
is: SBO:0000247
type: Species
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine

metaR CYTK10
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (CMP,dGTP)
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110021#

metaR ITPtn
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
reactant: MODEL1310110021#
fast: false
type: Reaction
name: ITP nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110021#_9a09b898_a044_4fc8_87bf_cd2960d38955
is encoded by: hsa:4891
name: SLC11A2
initial concentration: NaN
initial amount: NaN
is: B4DK84
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaR r2094
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaM h2o2 e
initial amount: NaN
has only substance units: false
is: CHEBI:16240
is: HMDB03125
boundary condition: false
name: hydrogen peroxide
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species

metaR EX CE1943 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermidine dialdehyde exchange
type: Reaction

metaM lnlccoa r
type: Species
boundary condition: false
initial amount: NaN
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
is: SBO:0000247
name: linoleic coenzyme A
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_8b8b4e12_0440_4888_9e7b_8071a9042ac9
is encoded by: hsa:3141
constant: false
boundary condition: true
type: Species
name: HLCS
is: SBO:0000252
is: P50747
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR SRTNtu
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
fast: false
modifier: MODEL1310110021#
type: Reaction
name: Serotonin uniport
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110021#

metaM thcholstoic c
is: SBO:0000247
is: HMDB03873
boundary condition: false
constant: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
initial amount: NaN
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial concentration: 1.0
has only substance units: false

metaR TSTSTERONEtr
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
name: testosterone intracellular transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#

metaM o2s e
initial concentration: 1.0
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: CHEBI:18421
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB02168
name: superoxide
constant: false

metaM hpyr c
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
name: 3-hydroxypyruvate
is: CHEBI:17180
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01352
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_07dc8316_e1db_4678_87a3_23f05149c397
is: Q9UPY5
name: SLC7A11
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:23657

metaR THMP
name: thiamin phosphatase
reactant: MODEL1310110021#
is described by: ECO:0000000
reversible: false
type: Reaction
product: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD

metaR r2096
kinetic law: MODEL1310110021#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_cea913c3_c9dc_4969_9e53_7cb27e15a20d
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: P23786
initial concentration: NaN
constant: false
name: CPT2
is encoded by: hsa:1376
type: Species

W3 CDTF: Fri Aug 31 03:48:44 BST 2012

metaM dcdp m
is: HMDB01245
name: dCDP(3-)
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
is: CHEBI:58593

http://identifiers.org/biomodels.db/MODEL1310110021#_ed525a8a_5453_4e39_9560_fc9c03381698
initial concentration: NaN
name: SLC27A2
is encoded by: hsa:11001
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: O14975

metaM docohexcoa m
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB06294
boundary condition: false
name: 2,4,7,10,13,16-docosahexenoylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_fde79eb7_1565_4650_8546_2a5e4aaf2737
is: SBO:0000252
is encoded by: hsa:4731
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: P56181
name: NDUFV3

metaR r0365
reversible: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000176
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59

metaR r1603
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_2434cfe6_9d68_4109_a1d1_4acd6e5a24f7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6718
boundary condition: true
type: Species
has only substance units: false
is: P51857
name: AKR1D1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_0d13f083_d0a5_446d_ab41_c5686c4a7675
has only substance units: false
name: GPX6
initial concentration: NaN
is encoded by: hsa:257202
boundary condition: true
is: SBO:0000252
type: Species
is: P59796
initial amount: NaN
constant: false

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM sphmyln hs c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: sphingomyelin betaine
is: CHEBI:58216

metaM CE4872 c
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
type: Species
is: HMDB00127
is: CHEBI:15748
constant: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_f1c41ea1_6f48_4def_9ead_de0a956e22e0
has only substance units: false
type: Species
boundary condition: true
name: GCK
is encoded by: hsa:2645
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaR r2095
fast: false
reactant: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110021#

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM dcdp n
name: dCDP(3-)
type: Species
is: HMDB01245
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
initial amount: NaN
is: CHEBI:58593
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_71656bde_244c_4fbd_8d52_995cd1b6b017
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:AI818585
name: _AI818585_1_c
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaM gua c
is: HMDB00132
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:16235
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: C00242
name: Guanine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_c40ba10d_36d2_4cfd_9072_2c84ad8964e5
is: SBO:0000252
type: Species
is encoded by: hsa:23517
is: Q3MHC9
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: SKIV2L2
has only substance units: false

W3 CDTF: Fri Aug 31 03:48:44 BST 2012

metaM cdp n
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:58069
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
is: HMDB01546
boundary condition: false
constant: false
name: CDP(3-)

metaR CHOLESTle
name: hydrolysis of cholesterol ester by cholesterol esterase
reactant: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110021#
fast: false
is: SBO:0000176
modifier: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.1.13

http://identifiers.org/biomodels.db/MODEL1310110021#_1e19d534_3986_4705_9af2_66924b683c96
initial amount: NaN
name: RFK
type: Species
is encoded by: hsa:55312
boundary condition: true
has only substance units: false
is: B2RDZ2
is: SBO:0000252
initial concentration: NaN
constant: false

metaM dgtp c
is: C00286
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
type: Species
boundary condition: false
name: dGTP
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16497
is: HMDB01440

http://identifiers.org/biomodels.db/MODEL1310110021#_f32c0bdf_cdaa_48bb_a92a_60c6a6d4932e
has only substance units: false
name: PIK3CB:PIK3R1
has part: B4DER4
is encoded by: hsa:5295
initial concentration: NaN
initial amount: NaN
type: Species
has part: B3KT19
constant: false
is encoded by: hsa:5291
boundary condition: true
is: SBO:0000297

metaR ASNS1
is described by: ECO:0000269
name: asparagine synthase (glutamine-hydrolysing)
reactant: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (440.1) or (440.3) or (440.2) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 6.3.5.4 Confidence Level: 4 AUTHORS: PMID:2564390,PMID:2886907 NOTES:
reversible: false
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.4

metaR r1604
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
fast: false

metaR 5HLTDL
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:1540578 NOTES:SAB
type: Reaction
fast: false
is described by: ECO:0000269
reactant: MODEL1310110021#
product: MODEL1310110021#
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
is version of: http://identifiers.org/ec-code/4.1.1.28
reversible: false
is: SBO:0000176

metaR HISCAT1
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_91d1a9a1_8fc9_4fa3_afa9_833259c2fe0d
name: AADAT
type: Species
initial amount: NaN
is: Q4W5N8
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:51166
has only substance units: false
initial concentration: NaN

metaR BILIRUBt2
product: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
reversible: true
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110021#
name: bilirubin transport via bicarbonate countertransport
kinetic law: MODEL1310110021#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110021#_f363662c_dcb1_4e83_a01f_dfad2987339e
constant: false
name: NME6
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10201
initial amount: NaN
is: O75414

metaM h2o2 c
type: Species
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
initial amount: NaN
is: CHEBI:16240
is: HMDB03125
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00027
name: Hydrogen peroxide
has only substance units: false

metaR FAOXC61m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR r2098
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM 3mox4hpac m
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: HMDB05175
is: CHEBI:28111
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde

http://identifiers.org/biomodels.db/MODEL1310110021#_b3f27409_b9b6_493c_859b_a7db8d8b2543
name: GCDH
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2639
constant: false
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_d76b1996_6a88_4597_aff5_afbb3ba9037f
type: Species
initial concentration: NaN
is: SBO:0000252
name: AMY1C
boundary condition: true
initial amount: NaN
is encoded by: hsa:278
constant: false
has only substance units: false
is: P04745

metaR GLRASE
is: SBO:0000176
fast: false
name: glucuronolactone reductase
reversible: true
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110021#

metaR PSFLIPm
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
name: phosphatidylserine flippase
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.1
reversible: false

W3 CDTF: Fri Aug 31 03:48:44 BST 2012

metaM glygn4 e
notes: FORMULA: C18H31O16X CHARGE: 0
boundary condition: false
has only substance units: false
is: HMDB00122
is: CHEBI:4167
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Species

metaR r2346
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110021#
reversible: true
product: MODEL1310110021#
name: Organic anion transporter 5 Utilized transport

metaR G6PDH2rer
is: SBO:0000176
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.47
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
reactant: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction
modifier: MODEL1310110021#

metaM mal L c
is: CHEBI:15589
initial amount: NaN
name: (S)-malate(2-)
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

metaR HDCEAtr
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
name: fatty acid transport via diffusion
fast: false

metaM dcmp c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
is: CHEBI:57566
is: C00239
name: dCMP
is: HMDB01202
initial amount: NaN
constant: false
boundary condition: false

metaM glyclt c
constant: false
initial amount: NaN
is: HMDB00115
name: glycolate
boundary condition: false
has only substance units: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: SBO:0000247
type: Species
is: CHEBI:29805
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_30d74b40_07f9_486e_bdb4_f90eb4283b34
is: P00390
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: GSR
is encoded by: hsa:2936
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_b50ec535_393f_4694_a525_bf004e2dbba0
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: SLC22A2
initial amount: NaN
is encoded by: hsa:6582

http://identifiers.org/biomodels.db/MODEL1310110021#_6cb338ad_6979_4789_8d3a_68777687453c
has only substance units: false
name: CLYBL
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:171425
constant: false

metaR PI5P3K
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
product: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
kinetic law: MODEL1310110021#
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.137

metaM malcoa r
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01175
constant: false
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384
type: Species
initial concentration: 1.0

metaR r2097
modifier: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110021#

metaM thp2c x
constant: false
name: 1-piperideine-6-carboxylate
is: CHEBI:16987
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB12130

metaM gua e
is: CHEBI:16235
type: Species
is: SBO:0000247
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0
initial amount: NaN
constant: false
name: guanine
is: HMDB00132
has only substance units: false
boundary condition: false

metaR RE1342C
is: SBO:0000176
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
name: RE1342
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_3a891dea_f128_4616_ad91_72e144c2c509
is: SBO:0000252
is: P55084
name: HADHB
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:3032
boundary condition: true
initial amount: NaN

metaR RE3252C
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
name: RE3252
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
fast: false
type: Reaction

metaR KHK
name: ketohexokinase
fast: false
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.3

metaM cholcoar x
type: Species
is: HMDB02178
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:58677
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)

metaR r2347
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
name: Organic anion transporter 5 Utilized transport
fast: false
is: SBO:0000185
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_f0329969_b788_4d97_a398_3f22b1f9226a
is encoded by: hsa:2678
initial concentration: NaN
constant: false
name: GGT1
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaR AMETt2m
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
fast: false
is described by: ECO:0000269
modifier: MODEL1310110021#
reversible: true
type: Reaction
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
product: MODEL1310110021#

metaR r1602
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM HC00361 c
type: Species
is: SBO:0000247
initial amount: NaN
name: sedoheptulose 1,7-bisphosphate(4-)
constant: false
has only substance units: false
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
boundary condition: false
initial concentration: 1.0
is: CHEBI:58335

http://identifiers.org/biomodels.db/MODEL1310110021#_53faa4ab_e144_4428_859c_3d98bbea8a79
name: GCDH
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q92947
constant: false
is encoded by: hsa:2639

metaR r0789
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.14.13.15

http://identifiers.org/biomodels.db/MODEL1310110021#_c06264f8_8ee3_4459_a033_d7693745f01f
constant: false
has only substance units: false
initial amount: NaN
name: ADH4
initial concentration: NaN
is encoded by: hsa:127
boundary condition: true
is: SBO:0000252
type: Species
is: P08319

metaR BUTt2r
modifier: MODEL1310110021#
fast: false
name: Butyrate transport via proton symport, reversible
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
reactant: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_610c0f10_674e_426b_a74f_c4fa645adfdf
is: B2RB13
is: SBO:0000252
name: ACSL6
has only substance units: false
boundary condition: true
is encoded by: hsa:23305
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_e2d4ac38_08dc_4fda_99cd_18817fe8d9fa
is: P32321
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: DCTD
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1635

http://identifiers.org/biomodels.db/MODEL1310110021#_8321e3d7_bd7b_4ea3_8d30_6a7e295439f3
is: SBO:0000252
boundary condition: true
name: DPYD
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1806
is: Q12882
constant: false
type: Species

metaR r2344
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110021#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_6cba670f_9cc8_485c_a210_de7510e53be8
name: ASNS
is: E9PCX6
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:440
is: SBO:0000252
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_79545247_3d7b_444e_83dd_be0fa37994fe
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is: B4DUG1
name: SLC24A1
is encoded by: hsa:9187
initial amount: NaN

metaM gln L e
initial concentration: 1.0
is: HMDB00641
has only substance units: false
constant: false
boundary condition: false
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
name: L-glutamine
is: SBO:0000247
is: CHEBI:18050

metaR PIt7
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
name: phosphate transport in/out via three Na+ symporter
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR r1527
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.2.1.1
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110021#

metaM succ x
constant: false
boundary condition: false
is: HMDB00254
name: Succinate
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial concentration: 1.0
is: CHEBI:30031

metaR 5ADTSTSTERONEte
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
name: 5 alpha dihydrotesterone transport
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110021#
is described by: ECO:0000000

metaR N2M2NMASNtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110021#
reversible: false
is described by: ECO:0000000
fast: false
name: n2m2nmasn transport, extracellular to lysosome
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR r2099
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110021#

metaM 44mctr r
initial amount: NaN
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
type: Species
is: HMDB01023
is: SBO:0000247
has only substance units: false
is: CHEBI:17813
initial concentration: 1.0
boundary condition: false
constant: false

metaR r0788
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
product: MODEL1310110021#
fast: false
is: SBO:0000176

metaM sphs1p e
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
is: HMDB00277
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false

metaR PI4P3K
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
name: phosphatidylinositol 4-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
modifier: MODEL1310110021#

metaM leuktrD4 e
type: Species
boundary condition: false
is: CHEBI:28666
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
has only substance units: false
is: HMDB03080
name: Leukotriene D4

http://identifiers.org/biomodels.db/MODEL1310110021#_26b33dbe_ba79_4af7_80af_a78d53205d68
is: SBO:0000252
is encoded by: hsa:5296
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: O00459
constant: false
name: PIK3R2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_dde4ea32_5a4e_4c28_97b5_9cd313802f7d
is encoded by: hsa:93034
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: Q96P26
boundary condition: true
initial concentration: NaN
name: NT5C1B

metaR EX CE1935 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine monoaldehyde exchange
type: Reaction

metaR r0360
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.16
type: Reaction
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000

metaR PIt8
reactant: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
fast: false
is: SBO:0000185
type: Reaction
reversible: true
name: phosphate transport in/out via Na+ symporter
is described by: ECO:0000006
kinetic law: MODEL1310110021#

metaM 3mop c
initial concentration: 1.0
is: CHEBI:28654
constant: false
has only substance units: false
boundary condition: false
name: 3-methyl-2-oxopentanoate
type: Species
is: HMDB00491
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial amount: NaN
is: SBO:0000247

metaR r1671
product: MODEL1310110021#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185

metaR FATP8t
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reversible: true
name: fatty acid electroneutral transport
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.3
is version of: http://identifiers.org/ec-code/6.2.1.7

metaR r1600
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM sql r
constant: false
initial amount: NaN
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: SBO:0000247
is: CHEBI:15440
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00256
name: squalene
type: Species

metaR r0149
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaR HSD3A1r
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
reactant: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_37d0abe9_af68_4d5b_8f6b_ef9712b05929
initial concentration: NaN
type: Species
is encoded by: hsa:2356
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: FPGS
initial amount: NaN
is: Q05932

http://identifiers.org/biomodels.db/MODEL1310110021#_57797171_a802_4938_8fa2_aa6042a62ff8
is encoded by: hsa:224
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: P51648
name: ALDH3A2

metaR RE1532M
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
name: RE1532
reversible: true
type: Reaction
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR FAOXC225C226m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_963204ca_a5f8_4fa5_88f6_5caa393d8892
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:1608
name: DGKG
initial concentration: NaN
is: P49619
is: SBO:0000252

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM 3aib D m
is: C03265
constant: false
boundary condition: false
initial amount: NaN
name: D-3-Amino-isobutanoate
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: SBO:0000247
is: HMDB02299

metaR RE2660C
is: SBO:0000176
reversible: true
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_b0500012_8262_4880_9017_77a894115c6b
type: Species
is: SBO:0000252
has only substance units: false
name: PANK1
is encoded by: hsa:53354
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR IDPtn
name: IDP nuclear transport
type: Reaction
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR PRODt2r
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
name: D-proline reversible transport via proton symport
reversible: true
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
is: SBO:0000185

metaR r0787
kinetic law: MODEL1310110021#
reversible: false
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110021#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is: SBO:0000176
reactant: MODEL1310110021#

metaR r1670
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110021#
is: SBO:0000185
name: Y+LAT2 Utilized transport
type: Reaction
fast: false

metaM gln L c
is: CHEBI:18050
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00641
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
name: L-glutamine
type: Species
initial amount: NaN
is: SBO:0000247

metaR GLYCLTtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
name: glycolate transport into peroxisome
is described by: ECO:0000000

metaM 4mop c
is: SBO:0000247
is: CHEBI:17865
initial concentration: 1.0
constant: false
is: HMDB00695
name: 4-methyl-2-oxopentanoate
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false

metaR CHATn
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.6
is described by: ECO:0000269
type: Reaction
reversible: true
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is: SBO:0000176
name: Choline O-acetyltransferase
reactant: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_0eed0c20_1655_427a_bfb9_024ba2a937aa
has only substance units: false
type: Species
is encoded by: hsa:93034
is: SBO:0000252
name: NT5C1B
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: B3KUK6

metaM dmpp x
has only substance units: false
name: prenyl diphosphate(3-)
is: HMDB01120
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57623
initial amount: NaN

metaR r2007
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM nmn c
has only substance units: false
is: C00455
is: SBO:0000247
initial amount: NaN
is: CHEBI:14649
initial concentration: 1.0
is: HMDB00229
type: Species
constant: false
name: NMN
boundary condition: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455

http://identifiers.org/biomodels.db/MODEL1310110021#_376cfa09_9e17_4c3f_86cd_03ea354bb97c
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: BAAT
initial amount: NaN
is: Q14032
initial concentration: NaN
is encoded by: hsa:570
boundary condition: true

metaM pmtcrn c
type: Species
is: CHEBI:17490
is: SBO:0000247
name: L-palmitoylcarnitine
boundary condition: false
is: HMDB00222
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN

metaM ppi x
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
type: Species
is: C00013
is: SBO:0000247
is: HMDB00250
is: CHEBI:33019
boundary condition: false
initial amount: NaN

metaR DRPA
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110021#
name: deoxyribose-phosphate aldolase
product: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110021#

metaM g1p c
is: CHEBI:58601
type: Species
has only substance units: false
constant: false
boundary condition: false
name: D-Glucose 1-phosphate
is: HMDB01586
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: C00103
initial concentration: 1.0

metaR MTHFD2
is described by: ECO:0000134
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
name: methylenetetrahydrofolate dehydrogenase (NAD)
modifier: MODEL1310110021#
is: SBO:0000176

metaR P45027A11m
is: SBO:0000176
modifier: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110021#
reversible: false
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
fast: false
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase

http://identifiers.org/biomodels.db/MODEL1310110021#_82566932_3a1a_4724_a31b_4b020e2de17e
type: Species
constant: false
boundary condition: true
is encoded by: hsa:1120
initial amount: NaN
name: CHKB
is: SBO:0000252
is: A0PJM6
has only substance units: false
initial concentration: NaN

metaM leuktrD4 c
type: Species
boundary condition: false
is: CHEBI:28666
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247
initial amount: NaN
name: Leukotriene D4
is: HMDB03080

metaM 3mop e
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: CHEBI:28654
initial amount: NaN
constant: false
is: HMDB00491
has only substance units: false
boundary condition: false

metaR CGLYt3 2
kinetic law: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
name: Cys-Gly transport in via proton symport
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
type: Reaction
fast: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#

metaM sphs1p c
initial concentration: 1.0
has only substance units: false
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
is: HMDB00277
type: Species
is: SBO:0000247
name: sphingosine 1-phosphate(1-)
initial amount: NaN
constant: false

metaM xol7ah3 m
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: CHEBI:28540
boundary condition: false
has only substance units: false
is: HMDB12455
type: Species
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: SBO:0000247
initial amount: NaN
constant: false

metaM fadh2 c
has only substance units: false
type: Species
is: HMDB01197
name: FADH2(2-)
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial concentration: 1.0
is: CHEBI:58307

metaR LNLNCGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110021#
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR IMPC
reversible: true
kinetic law: MODEL1310110021#
fast: false
name: IMP cyclohydrolase
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.3
modifier: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_57f1e814_907f_4e08_9111_2099ba3459a4
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:26266
name: SLC13A4
has only substance units: false
is: Q9UKG4
constant: false
is: SBO:0000252
boundary condition: true

metaR SQLEr
fast: false
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
reversible: false
name: Squalene epoxidase, endoplasmic reticular (NADP)
is version of: http://identifiers.org/ec-code/1.14.13.132
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110021#_2bf6c4e4_6ec8_4c99_96f1_868d3578555d
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: RPIA
is: P49247
is encoded by: hsa:22934
initial concentration: NaN

metaM xylu L c
is: HMDB00751
type: Species
is: CHEBI:17399
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: L-xylulose
has only substance units: false
initial concentration: 1.0

metaR TRPATB0tc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Tryptophan into the intestinal cells by ATB0 transporter
type: Reaction

metaM dgtp e
is: SBO:0000247
boundary condition: false
is: HMDB01440
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species
initial amount: NaN
constant: false
name: dGTP
has only substance units: false
is: CHEBI:16497
initial concentration: 1.0

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM pchol hs c
has only substance units: false
is: CHEBI:16110
boundary condition: false
name: Phosphatidylcholine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_b39f341d_272a_46e0_8f2d_833e610a0950
is: P31040
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6389
constant: false
name: SDHA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_87203e8d_b19e_45f9_a42b_1c6c572ae3e3
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: AOC2
constant: false
type: Species
is encoded by: hsa:314

http://identifiers.org/biomodels.db/MODEL1310110021#_a7db70b9_5e77_4722_ad65_1a507580c17d
initial concentration: NaN
is encoded by: hsa:3073
name: HEXA
is: SBO:0000252
initial amount: NaN
is: P06865
constant: false
boundary condition: true
type: Species
has only substance units: false

metaR DHFR
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
fast: false
name: dihydrofolate reductase
is described by: ECO:0000254
modifier: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.1.3

metaM thbpt c
initial amount: NaN
name: 5,6,7,8-tetrahydrobiopterin
is: CHEBI:15372
type: Species
boundary condition: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00027

metaR FAOXC11
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211 1 round of beta ox of branched chain FA from peroxisome NJ
reversible: false
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR DINt
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110021#
is: SBO:0000185
name: deoxyinosine transport via diffusion

metaR r0822
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
kinetic law: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

metaM pchol hs r
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16110
has only substance units: false
boundary condition: false
name: Phosphatidylcholine
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
type: Species
initial amount: NaN
constant: false

metaM ppi n
initial amount: NaN
name: diphosphate(3-)
initial concentration: 1.0
constant: false
is: CHEBI:33019
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_54080d89_3340_4407_9a11_a6164016cc02
has only substance units: false
name: SLC2A9
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:56606
initial amount: NaN

metaM 5adtststerone c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
boundary condition: false
is: HMDB02961
is: CHEBI:16330
initial amount: NaN
type: Species

metaM apoC m
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:32551
notes: FORMULA: XH CHARGE: 0
type: Species
has only substance units: false
name: Apocarboxlase (no lys residue)
boundary condition: false
is: HMDB00182

metaR r2122
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_76016098_87a8_45b4_8d5a_b19c1b96efd5
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: AMY2B
initial concentration: NaN
is encoded by: hsa:280
is: P19961
type: Species
constant: false
boundary condition: true

metaR H2O2tp
name: hydrogen peroxide peroxisomal transport via diffusion
type: Reaction
is: SBO:0000185
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000
product: MODEL1310110021#

metaM sphs1p r
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
has only substance units: false
is: HMDB00277
is: SBO:0000247
is: CHEBI:60119
initial amount: NaN

metaR r0145
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.8.3.1
reversible: true
is: SBO:0000176
reactant: MODEL1310110021#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
product: MODEL1310110021#
fast: false

metaM ppi m
type: Species
is: SBO:0000247
has only substance units: false
name: Diphosphate
initial amount: NaN
constant: false
is: CHEBI:33019
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
is: C00013
initial concentration: 1.0

metaR COUMARINte
type: Reaction
product: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false
reversible: true
name: xenobiotic transport

metaR r0821
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110021#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR SMPD3g
kinetic law: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.12
product: MODEL1310110021#
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
is described by: ECO:0000304
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reversible: false

metaR DMATTx
reactant: MODEL1310110021#
name: dimethylallyltranstransferase
reversible: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.5.1.1
is described by: ECO:0000134
kinetic law: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_f7f8ccc3_cc18_4a6e_b715_559b404639d5
boundary condition: true
is: Q16790
initial amount: NaN
constant: false
is encoded by: hsa:768
has only substance units: false
name: CA9
initial concentration: NaN
type: Species
is: SBO:0000252

metaM acnam c
is: CHEBI:35418
boundary condition: false
is: HMDB00230
has only substance units: false
is: SBO:0000247
constant: false
name: N-acetylneuraminate
initial amount: NaN
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_5a2f4ff1_1606_4b11_bb26_ed1fd473d8f0
constant: false
name: ALDH3B1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P43353
type: Species
is encoded by: hsa:221

http://identifiers.org/biomodels.db/MODEL1310110021#_626f331f_f520_47b5_853d_b92ba3f1371c
initial amount: NaN
is: SBO:0000252
name: CA3
type: Species
has only substance units: false
is: P07451
initial concentration: NaN
is encoded by: hsa:761
boundary condition: true
constant: false

metaR r0679
is: SBO:0000176
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
type: Reaction
reactant: MODEL1310110021#

metaM apoC Lys btn c
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: HMDB00182
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:32551
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_46c8afc1_2515_4805_9d7c_d4854f5a3bd3
name: _AI697028_1_m
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI697028
type: Species
is: SBO:0000252

metaR r2123
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_99faeece_c162_4bd9_beff_186e31c42396
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: O15382
is encoded by: hsa:587
boundary condition: true
name: BCAT2
has only substance units: false

metaR r1609
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
is: SBO:0000185
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR 1PPDCRp
kinetic law: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
product: MODEL1310110021#
reactant: MODEL1310110021#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_7298843f_e094_4b76_9168_ddd4d0ec7591
initial amount: NaN
is encoded by: hsa:6470
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: SHMT1
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_41c228ce_368a_4376_a175_e7821d4f36a1
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: ALPPL2
boundary condition: true
constant: false
initial amount: NaN
is: P10696
is encoded by: hsa:251

metaR HSD3B2r
reversible: false
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11384872,PMID:14643063 NOTES:see PMID: 14643063 specific cofactors/etc have not yet been determined - largely inferred NJ
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110021#
is described by: ECO:0000269
name: 3 beta-hydroxysteroid dehydrogenase type 1
reactant: MODEL1310110021#
is: SBO:0000176
fast: false
type: Reaction

metaR LCADi D
name: lactaldehyde dehydrogenase
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false

metaR MMMm
name: methylmalonyl-CoA mutase
reversible: true
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/5.4.99.2
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
type: Reaction
modifier: MODEL1310110021#

metaR HISTAtu
reactant: MODEL1310110021#
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110021#
is described by: ECO:0000269
name: Histamine uniport
product: MODEL1310110021#

metaR MECOALm
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
kinetic law: MODEL1310110021#
is described by: ECO:0000212
reversible: true
fast: false

metaR FAOXC103C102m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR r2120
product: MODEL1310110021#
type: Reaction
reversible: true
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110021#
is: SBO:0000185
fast: false

metaR GLXO1
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: false
is version of: http://identifiers.org/ec-code/1.1.2.4
type: Reaction
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000176
name: glyoxylate oxidase

metaR A4GALTg
modifier: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
fast: false
type: Reaction
name: Lactosylceramide 4-alpha-galactosyltransferase
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.228

http://identifiers.org/biomodels.db/MODEL1310110021#_95af5a3c_bf0c_40c7_9a75_d16fc5c723b6
initial amount: NaN
name: PLCG1
initial concentration: NaN
constant: false
is encoded by: hsa:5335
boundary condition: true
is: Q9UFY1
type: Species
has only substance units: false
is: SBO:0000252

metaR P4502F1
kinetic law: MODEL1310110021#
name: cytochrome P450 2F1
modifier: MODEL1310110021#
reversible: false
is: SBO:0000176
reactant: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (1572.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:1974816 NOTES:naphthalene epoxidation assumed to take place on outer membrane NJ
fast: false
is version of: http://identifiers.org/ec-code/1.14.14.1

metaR GLYt7 211 r
is described by: ECO:0000269
reactant: MODEL1310110021#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
is: SBO:0000185
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d3556142_fd56_4e15_a6ce_30aabc4f3028
is encoded by: hsa:1468
is: Q9UBX3
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC25A10
has only substance units: false
boundary condition: true
type: Species

metaM CE4872 m
has only substance units: false
type: Species
constant: false
is: HMDB00127
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: CHEBI:15748
initial amount: NaN
initial concentration: 1.0

metaR C3STDH1r
modifier: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reactant: MODEL1310110021#
reversible: false

metaR UGLT
is: SBO:0000176
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.12
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: UDPglucose--hexose-1-phosphate uridylyltransferase

metaR r1673
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is: SBO:0000185
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
reactant: MODEL1310110021#

metaR LALDO
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
is described by: ECO:0000000
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110021#
fast: false
reversible: true
modifier: MODEL1310110021#

metaR 34HPPte
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
fast: false
type: Reaction
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR r2121
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110021#
fast: false

metaR SPMTDe
is: SBO:0000185
type: Reaction
name: SPMTDe
reversible: true
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR FAOXC225C204m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM pmtcrn m
name: L-palmitoylcarnitine
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00222
constant: false
is: SBO:0000247
is: CHEBI:17490
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_58ce6e21_2198_4103_b41b_307d4bfeb5d8
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: B2R6S5
is encoded by: hsa:51727
constant: false
name: CMPK1
initial concentration: NaN

metaR DESAT20 1
kinetic law: MODEL1310110021#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
fast: false
is: SBO:0000176
product: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_eda292ff_f095_4485_83c5_4af96f1acfd6
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:953
constant: false
initial concentration: NaN
is: SBO:0000252
name: ENTPD1
is: Q86VV3

metaM ppi r
is: CHEBI:33019
constant: false
is: SBO:0000247
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
is: HMDB00250
has only substance units: false
name: Diphosphate
initial concentration: 1.0
type: Species
initial amount: NaN

metaM mal L e
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00156
initial concentration: 1.0
name: (S)-malate(2-)
type: Species
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaR r1607
fast: false
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction

metaM CE5788 e
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27485
is: SBO:0000247
is: HMDB02710
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
type: Species
has only substance units: false
name: kinetensin 1-7
boundary condition: false

metaM ctp c
is: C00063
type: Species
is: HMDB00082
initial amount: NaN
is: SBO:0000247
name: CTP
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:37563
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

http://identifiers.org/biomodels.db/MODEL1310110021#_985409d7_b582_4c43_b6a4_94204701e1f1
name: NME1:NME2
is encoded by: hsa:4830
initial concentration: NaN
initial amount: NaN
has part: P15531
type: Species
constant: false
is: SBO:0000297
has part: P22392
is encoded by: hsa:4831
has only substance units: false
boundary condition: true

metaR CYANt
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000
name: Cyanide transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_0ef0cfac_2475_4d73_b938_e349a9aa221e
initial concentration: NaN
is encoded by: hsa:8879
has only substance units: false
initial amount: NaN
is: O95470
boundary condition: true
is: SBO:0000252
type: Species
name: SGPL1
constant: false

metaR ECOAH9m
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
product: MODEL1310110021#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is described by: ECO:0000304
modifier: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_51e10551_7d28_4538_aaa6_35689a9dc5c6
boundary condition: true
is: Q9Y2C5
is encoded by: hsa:10050
type: Species
name: SLC17A4
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaM orot e
has only substance units: false
name: orotate
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
initial concentration: 1.0
is: HMDB00226
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_ae8dbd85_d88a_4292_8f24_21319c916f42
name: DHCR24
boundary condition: true
is encoded by: hsa:1718
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q15392
type: Species
constant: false
initial concentration: NaN

metaM 4hexdtetcoa m
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: false
is: HMDB02288
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 4,7,10,13-hexadecatetraenoylcoa
is: SBO:0000247

metaM gln L m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
is: CHEBI:18050
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: L-glutamine

metaR ALCD21 D
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.99.24
reactant: MODEL1310110021#
is described by: ECO:0000304
name: alcohol dehydrogenase (D-1,2-propanediol)
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
product: MODEL1310110021#
fast: false
reversible: false
kinetic law: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.1
modifier: MODEL1310110021#

metaR CITL
is: SBO:0000176
type: Reaction
fast: false
reversible: false
name: Citrate lyase
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000

metaR HMGCOAtm
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport

http://identifiers.org/biomodels.db/MODEL1310110021#_6be8040f_5b29_40e8_b139_fce616ad9f99
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI222095
initial amount: NaN
name: _AI222095_1_e
constant: false
type: Species
initial concentration: NaN

metaR r1608
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM thymd e
type: Species
has only substance units: false
is: C00214
is: HMDB00273
name: Thymidine
initial amount: NaN
constant: false
is: CHEBI:17748
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_75492ea7_8f79_4fb8_b4fa_3efad044e41a
constant: false
is: SBO:0000252
boundary condition: true
is: Q16853
is encoded by: hsa:8639
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: AOC3
type: Species

metaR FERO
type: Reaction
modifier: MODEL1310110021#
is described by: ECO:0000134
product: MODEL1310110021#
name: ferroxidase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
reactant: MODEL1310110021#
fast: false

metaR MECOAS1m
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is described by: ECO:0000304
reactant: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
fast: false
name: mesaconate--CoA ligase (GDP-forming)
is: SBO:0000176
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.4

http://identifiers.org/biomodels.db/MODEL1310110021#_3bf3e8a5_09b4_4eab_b9b2_6d971e91d074
name: GMPPA
is encoded by: hsa:29926
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM oh1 c
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01039
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
initial amount: NaN
is: C01328
type: Species

metaM xol7ah3 c
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: HMDB12455
name: 5beta-cholestane-3alpha,7alpha,26-triol
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:28540
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species

metaM 4hpro LT m
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
name: trans-4-hydroxy-L-proline
is: CHEBI:18095
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB00725

metaM mmcoa S m
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
initial concentration: 1.0
is: CHEBI:57327
type: Species
initial amount: NaN
is: HMDB02310
boundary condition: false
name: (S)-methylmalonyl-CoA(5-)
is: SBO:0000247
has only substance units: false

metaM xu1p D c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
name: D-Xylulose 1-phosphate
is: HMDB06534
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_a87000f6_2fc5_499d_bc2e_769d2f652eb8
initial concentration: NaN
is encoded by: hsa:5294
is: SBO:0000252
has only substance units: false
type: Species
name: PIK3CG
is: P48736
constant: false
initial amount: NaN
boundary condition: true

metaR ADCim
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
type: Reaction
is: SBO:0000176
name: Acetoacetate decarboxylation (irreversible), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
kinetic law: MODEL1310110021#

metaM dgchol e
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00637
type: Species
is: SBO:0000247
boundary condition: false
name: glycochenodeoxycholate
is: CHEBI:36252
initial concentration: 1.0

metaR r1678
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110021#
modifier: MODEL1310110021#
reversible: false
fast: false

metaM lnlncgcoa r
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
is: CHEBI:57363
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB06368
has only substance units: false

metaM glac c
initial concentration: 1.0
is: CHEBI:18268
name: D-glucurono-6,3-lactone
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB06355
type: Species
boundary condition: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
has only substance units: false

metaR XYLTt
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
name: Xylitol transport via passive diffusion
reversible: true
product: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#

metaM udpg r
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0
type: Species
is: CHEBI:58367
constant: false
is: HMDB00286

metaM ctp e
initial amount: NaN
is: HMDB00082
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP(4-)
is: CHEBI:37563
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_472a386c_1d60_4c35_a179_556cfa8f2600
boundary condition: true
constant: false
initial concentration: NaN
is: P00505
has only substance units: false
type: Species
initial amount: NaN
name: GOT2
is encoded by: hsa:2806
is: SBO:0000252

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_2ab5c168_9e83_4d13_9838_e74851280363
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
name: IDH1
has only substance units: false
is encoded by: hsa:3417
is: O75874

metaM 3hexdtetcoa m
is: HMDB02288
boundary condition: false
initial concentration: 1.0
name: 3,7,10,13-hexadecatetraenoylcoa
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

metaR r1605
fast: false
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000

metaM orot c
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: C00295
is: CHEBI:30839
type: Species
initial concentration: 1.0
name: Orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: HMDB00226

metaM o2s c
boundary condition: false
is: HMDB02168
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: superoxide
initial concentration: 1.0
is: CHEBI:18421

http://identifiers.org/biomodels.db/MODEL1310110021#_5cb3c283_84fe_4a2e_a14b_73a33e19eba9
boundary condition: true
is encoded by: hsa:5332
is: SBO:0000252
has only substance units: false
type: Species
is: Q15147
initial amount: NaN
name: PLCB4
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_3ba92fdc_49bc_47ec_936d_ba048f427bf6
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9Y259
initial amount: NaN
constant: false
name: CHKB
type: Species
is encoded by: hsa:1120

metaR r1453
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
fast: false

metaR r0142
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is: SBO:0000176
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false
is described by: ECO:0000000

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

metaR r1454
product: MODEL1310110021#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110021#
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
reversible: false

metaM pail34p hs c
is: CHEBI:57658
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR RBFK
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
name: riboflavin kinase
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000269
fast: false
reversible: false
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.26

metaR GLNLASEer
type: Reaction
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reversible: true
name: gluconolactonase, endoplasmic reticulum
kinetic law: MODEL1310110021#
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_07bfec63_8e3c_46b2_ad69_3e5d4fe14055
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: ENPP1
boundary condition: true
initial amount: NaN
is: P22413
is encoded by: hsa:5167

metaM HC10852 r
boundary condition: false
initial amount: NaN
is: CHEBI:61540
name: palmitoleyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_91d8fb8f_71de_4c3f_9336_6d3c5278bf22
boundary condition: true
has only substance units: false
is: Q9NYR8
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:50700
name: RDH8

metaR r1606
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
fast: false
reversible: true
product: MODEL1310110021#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#

metaM 3mop m
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: HMDB00491
type: Species

metaR ALASm
product: MODEL1310110021#
type: Reaction
name: 5-aminolevulinate synthase
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.29
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.37
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
is described by: ECO:0000254
modifier: MODEL1310110021#
fast: false

metaM dolglcp L c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
type: Species
constant: false
has only substance units: false
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: CHEBI:15812

metaM dcmp n
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01202
constant: false
name: dCMP(2-)
has only substance units: false
is: SBO:0000247
is: CHEBI:57566

metaM oh1 e
initial concentration: 1.0
type: Species
name: hydroxide ion
notes: FORMULA: HO CHARGE: -1
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01039
is: C01328
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_be5beb44_ddf5_4013_bb51_e1bb396a677e
has only substance units: false
initial concentration: NaN
is: P23378
constant: false
name: GLDC
type: Species
is encoded by: hsa:2731
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_48360e47_f3c8_4185_aaa8_32f0cebccaaa
type: Species
is: SBO:0000252
is: B7Z3W8
initial amount: NaN
is encoded by: hsa:6536
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
name: SLC6A9

metaR RE3000M
name: RE3000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true

metaR ASPte
reactant: MODEL1310110021#
name: diffusion of aspartate into blood
kinetic law: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000134

metaR FCOAH
is: SBO:0000176
name: formyl coa hydrolase
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:11341778,PMID:11591435 NOTES:Note - formcoa formula is uncharged - the correct is FACOAH2 w/ forcoa NJ
reactant: MODEL1310110021#
reversible: false
fast: false
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_d4d75a67_ad5e_4a83_b0e7_be77f08f17ba
is encoded by: hsa:5336
initial concentration: NaN
is: P16885
is: SBO:0000252
boundary condition: true
name: PLCG2
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM dhap c
name: Dihydroxyacetone phosphate
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57642
constant: false
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false
is: HMDB01473
is: C00111
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_852d811d_2faf_422a_b5c7_72b367e595d4
is encoded by: hsa:2987
initial amount: NaN
is: Q16774
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: GUK1
has only substance units: false

metaR r0475
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction

metaM phytcoa c
name: phytanoyl-CoA(4-)
boundary condition: false
is: CHEBI:57391
is: HMDB01359
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
is: SBO:0000247
constant: false
type: Species

metaR r0557
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
is: SBO:0000176
type: Reaction
modifier: MODEL1310110021#
product: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_b31b924d_070b_4112_a2d2_5d8f22b108c9
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:80201
name: HKDC1
is: B3KT70
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_3be1bd7b_e785_46e6_85ce_d11437ae3b09
initial concentration: NaN
has only substance units: false
name: MTHFD2L
constant: false
boundary condition: true
type: Species
is encoded by: hsa:441024
initial amount: NaN
is: Q9H903
is: SBO:0000252

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM CE2431 m
is: CHEBI:57795
is: SBO:0000247
has only substance units: false
name: cis-deca-4-enoyl-CoA
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
type: Species

metaR CO2ter
is described by: ECO:0000000
kinetic law: MODEL1310110021#
is: SBO:0000185
name: CO2 endoplasmic reticular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
fast: false

metaR CSCPASEly
kinetic law: MODEL1310110021#
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: chondroitin sulfate C proteoglycan protease, lysosome (endosome)

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaM thcrm hs g
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:24636
name: trihexosyl ceramide
constant: false
type: Species
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110021#_f7f097d4_4ea3_46de_857e_85c393283b72
name: CDA
is: P32320
boundary condition: true
constant: false
is encoded by: hsa:978
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN

metaR FAOXC143C123m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_0bda6dc1_593b_4e93_ad26_ad15f1ab355b
boundary condition: true
type: Species
name: SLC7A10:SLC3A2
has part: Q9NS82
has only substance units: false
initial concentration: NaN
has part: P08195
is encoded by: hsa:6520
initial amount: NaN
is encoded by: hsa:56301
is: SBO:0000297
constant: false

metaR r1553
is described by: ECO:0000000
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110021#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR r1552
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110021#
reversible: true
is described by: ECO:0000000

metaM cit m
initial amount: NaN
is: HMDB00094
boundary condition: false
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
type: Species
name: Citrate
initial concentration: 1.0
is: SBO:0000247
is: C00158
is: CHEBI:16947

http://identifiers.org/biomodels.db/MODEL1310110021#_53955ba0_663d_4f04_90d1_fa23bf8e89f4
has only substance units: false
initial amount: NaN
is: P30838
initial concentration: NaN
name: ALDH3A1
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:218

http://identifiers.org/biomodels.db/MODEL1310110021#_54d7a322_8ff7_41a1_b6ef_c0523c570721
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: _AI285872_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI285872
initial concentration: NaN

metaR HMGCOASim
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.3.10
type: Reaction
fast: false
product: MODEL1310110021#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
name: Hydroxymethylglutaryl CoA synthase (ir)

http://identifiers.org/biomodels.db/MODEL1310110021#_f9435cc2_83a7_41d5_987d_6ed699bbc3d7
is encoded by: hsa:U37519
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: _U37519_1_e
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_af3ed35c_e240_4197_afed_828047cdbcb8
is encoded by: hsa:219
is: SBO:0000252
initial amount: NaN
name: ALDH1B1
is: P30837
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN

metaR CRNtHa
fast: false
name: L-carnitine outward transport (H+ antiport)
reversible: false
kinetic law: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6583.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB H+ stoichiometry unknown
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_b54d47b3_70f9_4289_a386_2cea85150273
initial amount: NaN
is encoded by: hsa:10327
initial concentration: NaN
constant: false
name: AKR1A1
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR r0556
product: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.19.1
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
type: Reaction
modifier: MODEL1310110021#
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
fast: false

metaM crn r
constant: false
is: HMDB00062
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
name: (R)-carnitine
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:16347

http://identifiers.org/biomodels.db/MODEL1310110021#_15b9eef1_2bc9_4838_9d53_6509fb76c211
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5297
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: PI4KA
is: B4DYG5

metaR ILETAm
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000269
name: isoleucine transaminase, mitochondrial
product: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_cb040ee0_cea6_44d3_8ef8_f36c349a01b3
is: Q99944
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:80864
name: EGFL8

metaM lys L m
constant: false
boundary condition: false
name: L-lysinium(1+)
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00182
is: SBO:0000247
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_e7f120c4_6b5e_41bf_a3fc_52787faf8912
is: P49753
type: Species
is encoded by: hsa:10965
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ACOT2
boundary condition: true
constant: false

metaM na1 c
is: CHEBI:4541
constant: false
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
initial amount: NaN
is: C01330
name: Sodium
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c3d9c065_5388_4ec2_a62b_c656786a447c
name: OGDH
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: Q02218
is encoded by: hsa:4967
type: Species
initial concentration: NaN
has only substance units: false

metaR EX srtn LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Serotonin exchange
type: Reaction

metaM CE5120 m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
is: CHEBI:57923
name: trans-2-cis-8-tetradecadienoyl-CoA
initial amount: NaN
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d6c96e30_aae8_4d66_b7ab_b3b1f94f0156
is encoded by: hsa:4728
is: O00217
name: NDUFS8
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM hdca r
is: CHEBI:7896
name: Hexadecanoate (n-C16:0)
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: C00249
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00220
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaM dhap e
has only substance units: false
boundary condition: false
is: CHEBI:57642
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
name: glycerone phosphate(2-)
is: HMDB01473
initial amount: NaN
type: Species

metaR LTA4H
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/3.3.2.6
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
name: Leukotriene A-4 hydrolase
modifier: MODEL1310110021#
is described by: ECO:0000134
reversible: false
is: SBO:0000176
product: MODEL1310110021#
fast: false

metaM gsn c
has only substance units: false
is: SBO:0000247
name: Guanosine
initial concentration: 1.0
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
type: Species
constant: false
is: C00387
initial amount: NaN
boundary condition: false
is: CHEBI:16750
is: HMDB00133

metaR r1291
name: Postulated transport reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true
fast: false
type: Reaction

metaM xoltriol c
has only substance units: false
is: CHEBI:16496
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
type: Species
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01457

metaR r0559
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
reversible: true

metaM mescoa m
name: Mesaconyl-CoA
initial amount: NaN
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
constant: false
boundary condition: false
is: C06028
is: CHEBI:27969
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaM amet r
has only substance units: false
initial amount: NaN
is: CHEBI:15414
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
is: HMDB01185
name: S-adenosyl-L-methionine
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_cded6892_00b1_4066_a1b1_13063a6b7663
name: SLC16A2
initial concentration: NaN
is: P36021
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6567
initial amount: NaN

metaM datp m
initial amount: NaN
initial concentration: 1.0
is: HMDB01532
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:61404
is: SBO:0000247
name: dATP
is: C00131
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131

metaM eandrstrn r
is: CHEBI:27771
has only substance units: false
constant: false
initial amount: NaN
name: 16alpha-hydroxydehydroepiandrosterone
is: HMDB00352
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h3,12-16,20-21H,4-10H2,1-2H3/t12-,13+,14-,15-,16+,18-,19-/m0/s1 EHMN_ABBREVIATION: C05139

metaR FAS180COA
reactant: MODEL1310110021#
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
name: fatty-acyl-CoA synthase (n-C18:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_8d6fedeb_b4d5_456a_be77_cf902e60a19b
is encoded by: hsa:9563
initial amount: NaN
constant: false
is: O95479
is: SBO:0000252
name: H6PD
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_8dfe6308_8fb2_4ba1_a71c_8debefc5ef4c
boundary condition: true
has only substance units: false
is: P11678
name: EPX
constant: false
initial concentration: NaN
is encoded by: hsa:8288
initial amount: NaN
type: Species
is: SBO:0000252

metaM fe3 c
notes: FORMULA: Fe CHARGE: 3
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: Fe3+
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB12943

metaM mercplaccys e
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB06512
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
name: 3-mercaptolactate-cysteine disulfide

http://identifiers.org/biomodels.db/MODEL1310110021#_661b34f6_7f31_44c5_af70_da95d50588d6
is: Q9UBM7
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:1717
initial amount: NaN
has only substance units: false
name: DHCR7
type: Species

metaR r1292
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110021#
fast: false
is: SBO:0000185
name: Postulated transport reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR RPEc
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000134
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase
kinetic law: MODEL1310110021#
is: SBO:0000176

metaR r0558
is described by: ECO:0000000
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

metaR GAPD
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.12
name: glyceraldehyde-3-phosphate dehydrogenase
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_b7f57143_b30d_4d34_ba8f_574aa912ce5e
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:2876
boundary condition: true
name: GPX1
has only substance units: false

metaM na1 e
has only substance units: false
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
is: C01330
is: SBO:0000247
name: Sodium
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB00588
is: CHEBI:4541

http://identifiers.org/biomodels.db/MODEL1310110021#_e7bf807a_213e_4ee3_892f_abc98fbcf3ba
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: VNN2
type: Species
boundary condition: true
is encoded by: hsa:8875
is: A8K7W0

metaR ECOAH1m
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.18
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
product: MODEL1310110021#

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_63b34d55_0c27_446a_871c_8ba5101fbad7
boundary condition: true
has only substance units: false
is: SBO:0000252
is: P13073
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:1327
type: Species
name: COX4I1

metaR r1554
fast: false
reversible: true
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110021#
is: SBO:0000185

metaM ala L m
is: HMDB00161
is: CHEBI:16977
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f0034c02_fca0_47a9_bf79_123cb0ec473d
is: SBO:0000252
initial amount: NaN
is: Q8WWX8
name: SLC5A11
initial concentration: NaN
type: Species
is encoded by: hsa:115584
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_a05d0ff9_c54f_4ec2_98db_598a4bd3a080
name: SLC6A12
is encoded by: hsa:6539
type: Species
constant: false
boundary condition: true
is: P48065
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_7f394862_fce5_4196_93a2_bbd269b5885b
is encoded by: hsa:4357
constant: false
type: Species
is: P25325
name: MPST
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR EX coumarin LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: coumarin exchange
type: Reaction

metaR 5MTHFt
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000269
reversible: true
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110021#
product: MODEL1310110021#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
type: Reaction

metaR PSDm hs
name: Phosphatidylserine decarboxylase
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.65
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is described by: ECO:0000269
product: MODEL1310110021#

metaR GLYCTO1p
is described by: ECO:0000269
fast: false
modifier: MODEL1310110021#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
type: Reaction
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.3.15
name: Glycolate oxidase, peroxisome
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR MMEm
type: Reaction
is: SBO:0000176
modifier: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.1.99.1
name: methylmalonyl-CoA epimerase/racemase
product: MODEL1310110021#
reversible: true

metaM 2hb e
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: HMDB00008
name: 2-Hydroxybutyrate
has only substance units: false
is: SBO:0000247
is: CHEBI:1148
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
constant: false

metaR DNDPt34m
name: dGDP transport via dTDP antiport
is described by: ECO:0000269
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
kinetic law: MODEL1310110021#
fast: false
is: SBO:0000185
modifier: MODEL1310110021#

metaR UMPK3
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
name: UMP kinase (UTP)
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110021#

metaM crn m
boundary condition: false
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: CHEBI:16347
is: C00318
has only substance units: false
initial amount: NaN
is: HMDB00062
name: L-Carnitine
is: SBO:0000247
initial concentration: 1.0

metaM cl e
type: Species
name: Chloride
constant: false
is: SBO:0000247
is: C00115
has only substance units: false
is: HMDB00492
boundary condition: false
initial concentration: 1.0
notes: FORMULA: Cl CHARGE: -1
is: CHEBI:3966
initial amount: NaN

metaM hexdectecoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 2,4,7,10-hexadecatetraenoylcoa
type: Species
initial amount: NaN
is: HMDB02288
initial concentration: 1.0

metaR r0408
fast: false
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.3.5
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
reversible: true

metaM xylt c
is: HMDB02917
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17151
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
name: xylitol

metaR r0287
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
kinetic law: MODEL1310110021#
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110021#
reversible: false
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaM nadph r
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
type: Species
initial amount: NaN
is: C00005
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f08cd246_0387_481c_8cbc_f4fb253973e5
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: B4DG68
is: SBO:0000252
initial amount: NaN
name: NOS1
is encoded by: hsa:4842
boundary condition: true

metaR r1557
type: Reaction
reversible: true
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
is described by: ECO:0000000

metaR PROSTGH2t
is described by: ECO:0000269
kinetic law: MODEL1310110021#
name: Prostaglandin H2 transport
is: SBO:0000185
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
type: Reaction

metaM HC00250 e
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false
initial concentration: 1.0
is: CHEBI:29919
has only substance units: false
is: SBO:0000247
name: hydrosulfide

http://identifiers.org/biomodels.db/MODEL1310110021#_91fd1ff5_ae69_4b43_85ae_8d763f3c9c2c
is: SBO:0000252
initial concentration: NaN
name: NDUFA4
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:4697
initial amount: NaN
is: O00483
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_ad267407_0ba3_4ff2_aafc_d66135d51ff2
initial concentration: NaN
is: E9KL44
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:3030
type: Species
name: HADHA
boundary condition: true

metaM creat c
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
is: HMDB00064
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: creatine
constant: false
type: Species
is: CHEBI:16919
is: SBO:0000247

metaR UMPK2
type: Reaction
product: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000269
reversible: true
fast: false
name: UMP kinase (CTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM din e
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
type: Species
constant: false
is: CHEBI:28997
is: SBO:0000247
name: Deoxyinosine
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C05512
is: HMDB00071

metaR DADAe
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.4.4
reactant: MODEL1310110021#
is described by: ECO:0000269
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110021#
name: Deoxyadenosine deaminase, extracellular

metaR RE3006M
fast: false
modifier: MODEL1310110021#
name: RE3006
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
product: MODEL1310110021#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_b12b981f_a3b5_4b1b_a037_1d5c9e18ac86
is: SBO:0000252
name: HK3
has only substance units: false
is: P52790
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:3101
boundary condition: true

metaR RE2625M
is: SBO:0000176
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
name: RE2625
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110021#

metaR r0407
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.3.5

metaM mercplaccys c
name: 3-mercaptolactate-cysteine disulfide
is: HMDB06512
initial amount: NaN
type: Species
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0074
product: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110021#
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reactant: MODEL1310110021#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
modifier: MODEL1310110021#

metaM fe3 e
type: Species
is: HMDB12943
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
boundary condition: false
constant: false
name: Fe3+
has only substance units: false
is: CHEBI:29034

metaR FAS120COA
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110021#
fast: false
name: fatty-acyl-CoA synthase (n-C12:0CoA)
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110021#
reversible: false

metaM betald m
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
boundary condition: false
is: CHEBI:15710
is: HMDB01252
initial concentration: 1.0
type: Species
name: betaine aldehyde

metaM cgly c
initial amount: NaN
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
name: L-cysteinylglycine
is: SBO:0000247
constant: false
type: Species
is: CHEBI:4047
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00078

metaR r1556
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110021#

metaM hom L e
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00719
initial amount: NaN
is: CHEBI:15699
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
name: L-homoserine
boundary condition: false
initial concentration: 1.0
type: Species

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaM idp n
has only substance units: false
is: SBO:0000247
is: HMDB03335
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
is: CHEBI:58280
initial concentration: 1.0
name: IDP(3-)
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_67599eb2_7062_4277_837c_571874f18c2b
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:123041
initial amount: NaN
name: SLC24A4
is: SBO:0000252
type: Species

metaR ACCOAgt
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
modifier: MODEL1310110021#
product: MODEL1310110021#
name: acetyl-coa transport
kinetic law: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#

metaM tyr L c
initial concentration: 1.0
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
has only substance units: false
constant: false
is: HMDB00158
is: CHEBI:17895
boundary condition: false
name: L-tyrosine
is: SBO:0000247
type: Species
initial amount: NaN

metaM fdp c
is: HMDB01058
constant: false
initial amount: NaN
name: D-Fructose 1,6-bisphosphate
is: http://identifiers.org/pubchem.compound/3647
type: Species
boundary condition: false
is: SBO:0000247
is: C00354
has only substance units: false
is: CHEBI:16905
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_69a2bc9f_ac38_49c0_8b84_3d344429af68
is encoded by: hsa:10870
has only substance units: false
boundary condition: true
is: Q9UBK5
name: HCST
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false

metaM xylu D c
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01644
is: CHEBI:17140
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
name: D-xylulose

metaM 2maacoa m
initial amount: NaN
has only substance units: false
is: HMDB01157
name: 2-methylacetoacetyl-CoA(4-)
boundary condition: false
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
initial concentration: 1.0
is: CHEBI:57335
constant: false
is: SBO:0000247
type: Species

metaM xylt e
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
is: SBO:0000247
is: CHEBI:17151
initial amount: NaN
initial concentration: 1.0
type: Species
name: xylitol
is: HMDB02917
has only substance units: false

metaM cl c
is: CHEBI:3966
name: Chloride
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
is: C00115
boundary condition: false
is: HMDB00492
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_0c14a3bd_6bf0_42ea_9d0c_de0f0a33e25d
type: Species
constant: false
name: MBOAT2
has only substance units: false
is: Q6ZWT7
is encoded by: hsa:129642
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM CE5101 m
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
is: CHEBI:57795
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false

metaM HC00250 c
type: Species
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:29919
constant: false
name: hydrosulfide
is: SBO:0000247

metaR r1559
fast: false
reversible: true
product: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR GGT6
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
is described by: ECO:0000000
product: MODEL1310110021#
name: Gamma-glutamyltransferase
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110021#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_3fe4f8fe_84c3_4cc0_99e8_fb47d5a6230d
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:51095
is: Q96Q11
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: TRNT1

http://identifiers.org/biomodels.db/MODEL1310110021#_479df01b_d581_496b_afcf_696a8a539f40
initial amount: NaN
is: B2RD24
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:25902
type: Species
name: MTHFD1L
has only substance units: false

metaR r0208
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
is: SBO:0000176
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
fast: false
modifier: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/4.4.1.1

metaR FAOXC160
reversible: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110021#
name: Beta oxidation of long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110021#_ac156482_6b20_458d_9c64_d58c25614361
boundary condition: true
is encoded by: hsa:56848
constant: false
type: Species
is: Q9NRA0
initial concentration: NaN
name: SPHK2
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r0409
kinetic law: MODEL1310110021#
type: Reaction
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.10
product: MODEL1310110021#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
modifier: MODEL1310110021#
reactant: MODEL1310110021#

metaM hom L c
constant: false
name: L-homoserine
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00719
is: CHEBI:15699

http://identifiers.org/biomodels.db/MODEL1310110021#_53f62e18_53c4_4917_b405_4850fa069799
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: CTPS2
has only substance units: false
initial amount: NaN
is: Q9NRF8
initial concentration: NaN
is encoded by: hsa:56474

metaM cgly e
is: SBO:0000247
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: CHEBI:4047
is: HMDB00078
name: L-cysteinylglycine
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM c12dccoa x
initial amount: NaN
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
is: C14143
is: SBO:0000247
constant: false
type: Species
is: HMDB04047
name: dodecanedioylcoa
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR LACLt
reversible: false
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
name: Lactate transport
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation

metaR MI34PP
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110021#
name: inositol-3,4-bisphosphate 4-phosphatase
kinetic law: MODEL1310110021#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.3.66

metaR O2tm
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
product: MODEL1310110021#
reversible: true
type: Reaction
name: O2 transport (diffusion)
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_b3d2c9f9_f6ca_415a_927c_6dfd50b7e8d3
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: _AU149534_1_c
initial concentration: NaN
is encoded by: hsa:AU149534
boundary condition: true

metaR CYSGLTH
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
fast: false
name: Glutathione:cystine oxidoreductase
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM

metaM pd3 c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
constant: false
is: HMDB06500
is: SBO:0000247
name: Previtamin D3
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_78510fd5_fe7a_4243_aae4_45e427ea0407
name: _AI435857_1_x
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:AI435857

metaR GLYCTDle
reversible: true
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#
name: difussion of glycerol accross the brush border membrane
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction

metaR VALt5m
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
fast: false
name: Valine reversible mitochondrial transport

http://identifiers.org/biomodels.db/MODEL1310110021#_26c4691d_b827_4259_9944_8afd36307d39
name: _AA081045_1_e
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:AA081045
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR RE2799C
is: SBO:0000176
name: RE2799
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
fast: false
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000

metaR CHLtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reversible: true
product: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
name: choline transport via diffusion (cytosol to mitochondria)
type: Reaction
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_3adc62b3_daee_4cd3_b6f4_99bc67953c71
name: RDH5
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5959
boundary condition: true
is: Q92781
has only substance units: false
constant: false
initial amount: NaN

metaR RE2954C
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
modifier: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
name: RE2954
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_c6342aa2_3187_4dbf_9728_df13f18f23ab
name: PTDSS1
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:9791
boundary condition: true
constant: false
is: P48651

metaR r2124
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110021#
is: SBO:0000185

metaR FAOXC16080m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_5ed7e7ca_fed3_4255_9be5_4524a4de8d8f
boundary condition: true
initial concentration: NaN
is encoded by: hsa:218
is: SBO:0000252
has only substance units: false
is: P30838
constant: false
initial amount: NaN
type: Species
name: ALDH3A1

metaM r5p r
boundary condition: false
type: Species
name: alpha-D-Ribose 5-phosphate
initial concentration: 1.0
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:18189
is: SBO:0000247

metaR r2125
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
reversible: true

metaR URIDK2m
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reversible: true
name: uridylate kinase (dUMP), mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
is described by: ECO:0000134
reactant: MODEL1310110021#

metaM 7dhchsterol c
has only substance units: false
is: CHEBI:17759
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial amount: NaN
initial concentration: 1.0
is: HMDB00032
name: cholesta-5,7-dien-3beta-ol
boundary condition: false
type: Species
constant: false
is: SBO:0000247

metaR PAIL HStn
is: SBO:0000185
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
name: phosphatidylinositol nuclear transport (diffusion)
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000000

metaR ABTti
type: Reaction
reactant: MODEL1310110021#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110021#
name: L-arabinitol transport via passive diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_8b51dd60_77cb_4d1e_bb84_8c68b2859b31
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
name: ETFB
has only substance units: false
is encoded by: hsa:2109

metaR Coqe
is described by: ECO:0000134
fast: false
is: SBO:0000185
type: Reaction
name: Transport of q10
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110021#

metaR 2HBO
fast: false
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
reactant: MODEL1310110021#
product: MODEL1310110021#
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_ecbab2ae_015e_4169_a344_8b161ebe72a4
is encoded by: hsa:4846
type: Species
initial amount: NaN
is: A0S0A7
name: NOS3
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM HC01602 c
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
is: C00234

http://identifiers.org/biomodels.db/MODEL1310110021#_3a3099c2_9131_4d30_8529_854898bdda46
initial concentration: NaN
constant: false
initial amount: NaN
is: F5H123
name: DYLX2
is encoded by: hsa:9856
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM lys L e
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00182
boundary condition: false
name: L-lysinium(1+)
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047

metaR VD3
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
name: Vitamin D3 formation
fast: false
product: MODEL1310110021#
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_958fe2d7_e6fe_443d_bfb3_dc89733d10ce
constant: false
type: Species
initial amount: NaN
name: ACP1
is: Q59EH3
is encoded by: hsa:52
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM cit e
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: citrate(3-)
is: CHEBI:16947
is: HMDB00094
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_288f9e33_c3ef_4072_b818_8dc3a124ef04
initial amount: NaN
initial concentration: NaN
type: Species
name: PFKL:PFKP
has only substance units: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:5211
constant: false
has part: Q7L2M7

metaM uri c
is: CHEBI:16704
constant: false
initial amount: NaN
is: SBO:0000247
is: C00299
name: Uridine
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
type: Species
has only substance units: false
boundary condition: false

metaM pglyc hs c
is: SBO:0000247
constant: false
type: Species
name: phosphatidylglycerol(1-)
initial concentration: 1.0
is: CHEBI:60523
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096

http://identifiers.org/biomodels.db/MODEL1310110021#_5677632e_c303_4df4_83ca_56d969a4643f
boundary condition: true
initial concentration: NaN
is: P19801
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: ABP1
is encoded by: hsa:26
initial amount: NaN

metaR r1298
type: Reaction
is: SBO:0000185
reversible: false
fast: false
name: Vesicular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaM ala D c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
name: D-alanine
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01310
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15570

metaM gullac r
name: L-gulono-1,4-lactone
is: SBO:0000247
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
is: CHEBI:17587
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB03466
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c46c65ed_a16f_429f_bf73_0888c6e3bf88
boundary condition: true
has only substance units: false
is encoded by: hsa:122970
is: SBO:0000252
name: ACOT4
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: Q8N9L9

metaR GLYt7 311 r
reversible: true
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000006
reactant: MODEL1310110021#
fast: false
name: glycine reversible transport via sodium and chloride symport (3:1:1)

metaR r0403
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
modifier: MODEL1310110021#
fast: false
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_e52c17c8_70c9_4317_b3f3_95bf3b60257c
constant: false
boundary condition: true
is encoded by: hsa:R06874
name: _R06874_1_r
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM cs c deg3 l
has only substance units: false
constant: false
initial concentration: 1.0
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3
is: SBO:0000247
is: HMDB00127
notes: FORMULA: C31H48NO32S2 CHARGE: -3
type: Species
boundary condition: false
is: CHEBI:15748
initial amount: NaN

metaM 4h2oglt m
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB02070
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
name: 4-hydroxy-2-oxoglutarate(2-)
initial concentration: 1.0
is: CHEBI:17742
boundary condition: false
constant: false

metaM chsterol r
constant: false
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: SBO:0000247
is: CHEBI:16113
is: HMDB00067
boundary condition: false
initial amount: NaN
name: cholesterol
type: Species
initial concentration: 1.0

metaR r2126
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reversible: true

metaR PRO Dtde
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction
name: D-proline transport, extracellular
reversible: true
product: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaR r0317
reversible: true
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176

metaM CE2418 m
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: HMDB11123
has only substance units: false
initial concentration: 1.0
is: CHEBI:28387
type: Species
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: SBO:0000247
constant: false
initial amount: NaN

metaM tre e
type: Species
is: C01083
is: SBO:0000247
is: CHEBI:16551
name: Trehalose
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00975
initial amount: NaN

metaR TSULt4 3
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
product: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
name: thiosulfate transport via sodium symport
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_c40ace57_51f5_4860_b625_ff6f173c8a5d
is: Q549M5
name: NDUFC2
type: Species
constant: false
is encoded by: hsa:4718
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_2ad948c7_67fc_4dd5_98f1_e892daf9e21e
boundary condition: true
is encoded by: hsa:53354
has only substance units: false
initial concentration: NaN
name: PANK1
type: Species
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_3231c1bc_bd84_431e_b491_9bd2a27acc3a
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:65263
is: Q53H96
constant: false
name: PYCRL
boundary condition: true

metaM Rtotal2 e
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial concentration: 1.0
is: HMDB00244
boundary condition: false
is: C00255
has only substance units: false
name: R total 2 position
initial amount: NaN
is: SBO:0000247
is: CHEBI:3554
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_c98f5309_8063_42e9_adcb_9c235077ebc5
has only substance units: false
boundary condition: true
is: Q8NFF2
constant: false
initial concentration: NaN
name: SLC24A4
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:123041

metaR ALCD21 L
name: alcohol dehydrogenase (L-1,2-propanediol)
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.99.24
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110021#
type: Reaction
fast: false
reversible: false
is: SBO:0000176

metaR AKR1D2
is: SBO:0000176
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
fast: false
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: false
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.1.3
is described by: ECO:0000269
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

metaR r0394
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
product: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4

metaM malthx e
boundary condition: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial amount: NaN
constant: false
name: Maltohexaose
is: http://identifiers.org/pubchem.compound/5041
has only substance units: false
is: SBO:0000247
is: C01936
type: Species
initial concentration: 1.0

metaR O2Stm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#
name: superoxide anion transport via diffusion (mitochondria)
fast: false
kinetic law: MODEL1310110021#
reversible: true
is: SBO:0000185

metaM gluside hs r
initial concentration: 1.0
is: CHEBI:18368
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
constant: false

metaM nadph x
boundary condition: false
is: CHEBI:57783
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C00005
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247

metaR r1299
reactant: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
product: MODEL1310110021#
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110021#

metaM ivcoa m
name: Isovaleryl-CoA
is: HMDB01113
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: CHEBI:57345
initial concentration: 1.0
initial amount: NaN

metaM prostgi2 e
is: HMDB01335
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
name: prostaglandin I2(1-)
is: CHEBI:57403
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_31146215_7ceb_415f_b718_cc650b106ba6
is encoded by: hsa:11332
is: SBO:0000252
constant: false
boundary condition: true
is: O00154
initial concentration: NaN
initial amount: NaN
type: Species
name: ACOT7
has only substance units: false

metaM tyr L e
type: Species
initial amount: NaN
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895
initial concentration: 1.0
is: SBO:0000247
is: HMDB00158
has only substance units: false
boundary condition: false
name: L-tyrosine
constant: false

metaR DDPGAm
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
fast: false
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD

metaR r2127
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110021#
type: Reaction
fast: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_06abd44c_4c54_4637_a6c5_d852232c8569
initial amount: NaN
name: SLC4A5
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57835
initial concentration: NaN
boundary condition: true
is: Q9BY07

metaM 34dhoxmand m
name: 3,4-Dihydroxymandelate
initial amount: NaN
has only substance units: false
is: HMDB01866
is: CHEBI:27637
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_5eed7bea_fc03_459c_8478_33c895e570f2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:27068
name: PPA2
constant: false
type: Species

metaR RE2079R
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
name: RE2079
type: Reaction
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000
is: SBO:0000176

metaM cit c
type: Species
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: C00158
name: Citrate
is: CHEBI:16947
is: HMDB00094
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false

metaR THRGLYexR
is: SBO:0000185
type: Reaction
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false

metaR r0395
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true

metaM galside hs e
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial amount: NaN

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110021#
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110021#
reversible: false
name: inositol-1,3,4,5-trisphosphate 5-phosphatase

metaM damp c
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58245
type: Species
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
name: dAMP(2-)
initial amount: NaN
is: HMDB00905
is: SBO:0000247

metaR r0181
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5

metaR PCm
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
is described by: ECO:0000269
name: pyruvate carboxylase
reactant: MODEL1310110021#
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.4.1.1
modifier: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_f333a21d_ad46_4c4c_8722_d3e9e1510e2a
constant: false
is encoded by: hsa:8802
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SUCLG1
type: Species
is: P53597

metaM uri e
type: Species
name: Uridine
is: HMDB00296
is: C00299
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
is: CHEBI:16704

metaM glyclt x
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial amount: NaN
initial concentration: 1.0
is: CHEBI:29805
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false
name: glycolate
is: HMDB00115

metaM sbt D c
has only substance units: false
type: Species
name: D-glucitol
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial amount: NaN
is: HMDB00247
is: CHEBI:17924
boundary condition: false

metaM pglyc hs e
has only substance units: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
boundary condition: false
is: CHEBI:60523
name: phosphatidylglycerol(1-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species

metaR G6Pter
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
name: glucose 6-phosphate endoplasmic reticular transport via diffusion

metaM HC02206 e
name: prostaglandin C1(1-)
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57399
initial amount: NaN

metaM creat e
is: CHEBI:16919
name: creatine
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: HMDB00064
boundary condition: false

metaM din c
is: CHEBI:28997
name: Deoxyinosine
is: HMDB00071
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C05512
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c43a0947_78e8_4648_963a_91845fb74b42
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ACO1
has only substance units: false
is encoded by: hsa:48
initial concentration: NaN
type: Species
is: P21399

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_c53649f5_9f03_42c7_84e4_b2c51ea28f90
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:18
name: ABAT
initial concentration: NaN
constant: false
boundary condition: true

metaR r2128
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
reactant: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110021#
type: Reaction
reversible: true

metaR MTHFCm
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/6.3.4.3
reversible: true
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reactant: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#

metaR r0400
product: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
modifier: MODEL1310110021#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_08e4a5c6_15a4_4448_ac19_1ee2ffcb71e6
constant: false
is encoded by: hsa:122622
name: ADSSL1
is: Q8N142
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR URATEt
name: urate export from cytosol
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaM CE0785 m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57795
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: SBO:0000247
name: cis,cis-myristo-5,8-dienoyl-CoA
type: Species
has only substance units: false

metaR r0186
fast: false
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
reversible: false
is: SBO:0000176

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

metaR HISSNAT5tc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR FBA4
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
product: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
kinetic law: MODEL1310110021#
fast: false
type: Reaction
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_18b19456_6a7b_429d_bbd3_16f89c6403b6
is: SBO:0000252
name: CTPS1
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1503
is: P17812
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_c49e0e9c_e380_46e7_99c0_df50628ff690
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: _AI601100_1_m
is encoded by: hsa:AI601100
boundary condition: true

metaR PNTK
fast: false
reactant: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110021#
name: pantothenate kinase
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110021#

metaM crn e
boundary condition: false
constant: false
is: C00318
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16347
initial amount: NaN
is: HMDB00062
name: L-Carnitine
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR ACGAM2E
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/5.1.3.8
is: SBO:0000176
name: N-acetylglucosamine 2-epimerase
is described by: ECO:0000269
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (5973.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.8 Confidence Level: 4 AUTHORS: PMID:12499362 NOTES:NCD
modifier: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
type: Reaction
reversible: true

metaR r1443
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
name: EC:1.3.3.6
reversible: false
fast: false

metaR r1669
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#
fast: false
name: Y+LAT2 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR SUCRe
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.10
kinetic law: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.1.20
is: SBO:0000176
name: sucrose hydrolyzing enxyme, extracellular
modifier: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000269

metaM CE0693 m
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
name: 3-oxolaur-6-cis-enoyl-CoA
is: CHEBI:28387
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB11123

metaR SBT Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
name: D-sorbitol transport, extracellular
fast: false
reversible: true

metaR FAOXC184m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaM cholcoaone x
is: HMDB06891
is: SBO:0000247
constant: false
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
type: Species
boundary condition: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
has only substance units: false
is: CHEBI:58507
initial concentration: 1.0

metaR LEUTAm
reversible: true
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is: SBO:0000176
name: leucine transaminase, mitochondrial
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR r0472
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#

metaM datp n
is: SBO:0000247
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
initial amount: NaN
boundary condition: false
is: C00131
constant: false
initial concentration: 1.0
name: dATP
type: Species
is: CHEBI:61404
is: HMDB01532

metaR r2129
product: MODEL1310110021#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_fefb29d2_e40f_478e_9fe2_09d398089c21
is encoded by: hsa:AI620219
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
name: _AI620219_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_8541769e_34b8_470b_bd53_9ced54780c62
has only substance units: false
name: _M68895_1_c
type: Species
initial amount: NaN
is encoded by: hsa:M68895
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM Lpipecol x
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
initial concentration: 1.0
is: HMDB00716
is: CHEBI:30913
type: Species
boundary condition: false
initial amount: NaN
name: L-pipecolic acid

metaM sbt D e
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: D-glucitol
is: SBO:0000247
initial amount: NaN
is: HMDB00247
type: Species
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110021#_9ff1ee0f_a428_4d7d_b71d_75131ffd1fcb
is: O14734
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ACOT8
is encoded by: hsa:10005

http://identifiers.org/biomodels.db/MODEL1310110021#_b2ce473a_bebd_432c_94a0_fed936ade262
initial amount: NaN
is encoded by: hsa:1376
name: CPT2
is: P23786
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_42fdb053_fbc4_41e3_8d5e_9db3d347a765
initial concentration: NaN
name: ACAA2
constant: false
boundary condition: true
is: P42765
type: Species
has only substance units: false
is encoded by: hsa:10449
initial amount: NaN
is: SBO:0000252

metaR ENGASE2ly
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
fast: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176

metaR CYSTGLUex
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
reversible: false
name: L-cystine/L-glutamate exchanger
fast: false
product: MODEL1310110021#

metaR PRPPS
kinetic law: MODEL1310110021#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.6.1
is: SBO:0000176
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110021#
is described by: ECO:0000000
name: phosphoribosylpyrophosphate synthetase
product: MODEL1310110021#

metaR CYTK14n
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110021#
fast: false
name: cytidylate kinase (dCMP,CTP),nuclear
is described by: ECO:0000269
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#

metaR FBA2
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.1.2.13
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110021#
reactant: MODEL1310110021#

metaM man6p c
is: HMDB01078
type: Species
is: CHEBI:17369
initial concentration: 1.0
boundary condition: false
name: D-Mannose 6-phosphate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
has only substance units: false
constant: false

metaR GLCAASE5ly
is: SBO:0000176
product: MODEL1310110021#
fast: false
type: Reaction
name: beta-glucuronidase, lysosomal
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR ITCOALm
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110021#
reversible: true
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110021#
fast: false
name: Itaconate--CoA ligase (ADP-forming), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110021#_e552e01a_c30b_42f3_b5c1_4bae310f6b9e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1841
has only substance units: false
is: P23919
name: DTYMK
type: Species
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_a64773d1_9b44_4185_911d_e58707fc476e
name: _AA532636_1_m
initial concentration: NaN
is encoded by: hsa:AA532636
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaR CYTK13
is: SBO:0000176
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM dcsptn1coa x
is: C16173
is: http://identifiers.org/pubchem.compound/47205483
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06513
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial amount: NaN
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1

metaR r2341
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110021#
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_f166e945_53a5_4fca_9e31_7337bf0183c0
is: P49915
constant: false
is encoded by: hsa:8833
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: GMPS
type: Species
has only substance units: false
initial concentration: NaN

metaM 6thf e
type: Species
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: hexaglutamyl folate (THF)
constant: false
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/169691

metaR G5SDym
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.2.1.41
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
name: glutamate-5-semialdehyde dehydrogenase (m)
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: false
modifier: MODEL1310110021#
product: MODEL1310110021#

metaR OCDCAtr
is: SBO:0000185
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
name: fatty acid transport via diffusion
reversible: true
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110021#

metaR r1551
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000

metaR RE0828E
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
name: RE0828
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.22
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e633d48d_daf9_4cdc_a6d6_3fd433a1e2db
constant: false
is: P19440
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2678
initial amount: NaN
name: GGT1
boundary condition: true
type: Species

metaM sbcoa x
is: SBO:0000247
has only substance units: false
name: suberylcoa
initial concentration: 1.0
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/16019966

metaR FACOAL160i
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
modifier: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
type: Reaction
reversible: false
product: MODEL1310110021#
name: C160 fatty acid activation

http://identifiers.org/biomodels.db/MODEL1310110021#_7d118045_d87e_4bc6_9905_0b8ce2dd843d
constant: false
initial amount: NaN
name: ACOT7
has only substance units: false
type: Species
is encoded by: hsa:11332
is: SBO:0000252
boundary condition: true
is: O00154
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_2ed692e4_fb34_4a3c_aacd_a522a42cd288
is: SBO:0000252
is encoded by: hsa:AI934540
initial amount: NaN
initial concentration: NaN
name: _AI934540_1_c
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR 3MOPte
is described by: ECO:0000134
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Transport of 3-methyl-2-oxopentanoate
type: Reaction
is: SBO:0000185

metaR r0399
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
product: MODEL1310110021#
reactant: MODEL1310110021#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
reversible: true
kinetic law: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_81a669a0_892f_48c9_a831_531708104f26
is encoded by: hsa:5290
initial amount: NaN
constant: false
initial concentration: NaN
has part: O00459
has only substance units: false
is: SBO:0000297
type: Species
name: PIK3CA:PIK3R2
is encoded by: hsa:5296
has part: P42336
boundary condition: true

metaR RE1233C
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
fast: false
name: RE1233
is: SBO:0000176
modifier: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_f32c54f9_6725_4d92_b8cf_6972f897c7e3
initial amount: NaN
is: SBO:0000297
constant: false
has part: Q9UM01
type: Species
is encoded by: hsa:9056
is encoded by: hsa:6519
initial concentration: NaN
has only substance units: false
has part: Q07837
name: SLC3A1:SLC7A7
boundary condition: true

metaR r0474
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176

metaM homoval m
is: CHEBI:545959
constant: false
is: SBO:0000247
boundary condition: false
name: Homovanillate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: HMDB00118
initial amount: NaN
type: Species

metaR CYTK14
kinetic law: MODEL1310110021#
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110021#
name: cytidylate kinase (dCMP,UTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR CDIPTr
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
reversible: true
product: MODEL1310110021#
name: phosphatidylinositol synthase (Homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.8.11
is: SBO:0000176
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_17dc1459_317a_44d7_b0c2_4accdb8f2ea1
constant: false
has only substance units: false
is encoded by: hsa:6520
is: P08195
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC3A2
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_4ee26215_f262_4ab5_9538_83fadde87f4a
boundary condition: true
is: SBO:0000252
name: DGKQ
initial amount: NaN
initial concentration: NaN
is: P52824
constant: false
has only substance units: false
is encoded by: hsa:1609
type: Species

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR r0829
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.37
modifier: MODEL1310110021#
reactant: MODEL1310110021#

metaM ala D e
is: HMDB01310
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: D-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
boundary condition: false
is: CHEBI:15570

metaM lys L c
name: L-lysinium(1+)
constant: false
boundary condition: false
is: CHEBI:32551
type: Species
is: HMDB00182
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaM leuleu e
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C12H24N2O3 CHARGE: 0
constant: false
name: Leucylleucine
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/94244

http://identifiers.org/biomodels.db/MODEL1310110021#_4a0608b2_8fec_4ac7_ac08_5569e1159c13
has only substance units: false
is encoded by: hsa:81537
type: Species
name: SGPP1
boundary condition: true
constant: false
initial amount: NaN
is: Q9BX95
is: SBO:0000252
initial concentration: NaN

metaR r1935
kinetic law: MODEL1310110021#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
is: SBO:0000185

metaR ACACT5p
fast: false
reversible: false
kinetic law: MODEL1310110021#
is described by: ECO:0000269
modifier: MODEL1310110021#
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e7c29d38_faba_46f0_8433_ff9d77ea3cfe
has only substance units: false
constant: false
is: Q4FEB3
is encoded by: hsa:1215
initial amount: NaN
name: CMA1
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR CYSSNAT5tc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r2330
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110021#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110021#

metaR RE2626C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
type: Reaction
name: RE2626
reversible: true
is: SBO:0000176
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaM udp n
type: Species
boundary condition: false
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
has only substance units: false
initial concentration: 1.0
is: CHEBI:58223
initial amount: NaN
is: SBO:0000247
name: UDP(3-)

metaR r0179
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110021#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16

http://identifiers.org/biomodels.db/MODEL1310110021#_3fc3b661_3260_4f93_9f54_6f5f9ac167b5
type: Species
has only substance units: false
constant: false
name: INPP5E
boundary condition: true
is: SBO:0000252
is: Q9NRR6
is encoded by: hsa:56623
initial amount: NaN
initial concentration: NaN

metaM amet c
has only substance units: false
is: C00019
constant: false
name: S-Adenosyl-L-methionine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15414
is: HMDB01185
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

metaM chsterol m
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00067
initial amount: NaN
name: cholesterol
initial concentration: 1.0
is: CHEBI:16113
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaR r1665
product: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
reversible: true
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_5809a716_4b47_4e53_896a_65a112e8b68c
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:84693
initial concentration: NaN
is: Q96PE7
name: MCEE
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_b082baad_0dce_4856_b169_4abd3f696fdd
boundary condition: true
initial amount: NaN
name: MVK
has only substance units: false
is: B2RDU6
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4598

metaM h2o x
is: C00001
name: H2O
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
is: HMDB02111
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r0836
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
fast: false
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true

metaR r1934
reversible: false
kinetic law: MODEL1310110021#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000185
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dhf e
is: HMDB01056
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:57451
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: dihydrofolate(2-)
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_8fe1f4b3_21c6_4da4_b1d2_8c705b22c927
is: SBO:0000252
type: Species
name: _AI761708_1_m
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI761708
has only substance units: false

metaR r2331
product: MODEL1310110021#
type: Reaction
fast: false
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR TYRTA
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
name: tyrosine transaminase
reversible: true
product: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_535ed41f_6fad_4f49_8803_bab67e4c9e28
is: P17516
type: Species
is encoded by: hsa:1109
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: AKR1C4
constant: false
initial amount: NaN

metaM itaccoa m
boundary condition: false
constant: false
is: CHEBI:57381
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
has only substance units: false
is: HMDB03377
is: SBO:0000247
name: itaconyl-CoA(5-)

http://identifiers.org/biomodels.db/MODEL1310110021#_61f00842_e0b6_4e93_9b50_d09e89f70a1c
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P30613
is encoded by: hsa:5313
constant: false
initial amount: NaN
name: PKLR

http://identifiers.org/biomodels.db/MODEL1310110021#_32a1b998_5bcf_4b71_b1d5_921cabb3679f
constant: false
is encoded by: hsa:AA526438
initial amount: NaN
has only substance units: false
type: Species
name: _AA526438_1_m
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM duri e
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
boundary condition: false
is: C00526
initial amount: NaN
name: Deoxyuridine
has only substance units: false
constant: false
is: HMDB00012

metaM prostgh2 c
has only substance units: false
is: CHEBI:57405
boundary condition: false
type: Species
is: HMDB01381
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
constant: false
name: prostaglandin H2(1-)
initial concentration: 1.0
is: SBO:0000247

metaM chsterol l
has only substance units: false
is: HMDB00067
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
name: cholesterol
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16113
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c4ac4918_534e_4570_ad0d_3bfb0673be7e
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:80308
boundary condition: true
has only substance units: false
name: FLAD1
initial concentration: NaN
initial amount: NaN

metaR r0178
type: Reaction
modifier: MODEL1310110021#
product: MODEL1310110021#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.5.1.21
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
kinetic law: MODEL1310110021#

metaR r1666
is: SBO:0000185
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
name: Y+LAT2 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_bbe9762b_6e42_47c7_9658_21efdf67bd42
has only substance units: false
is: Q9NY65
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:1962
is: SBO:0000252
name: EHHADH
boundary condition: true
initial amount: NaN

metaR AHCYStr
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
is described by: ECO:0000000
is: SBO:0000185
name: S-Adenosyl-L-homocysteine intracellular diffusion
product: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_0de53064_3573_41a5_a8ca_ce8cb9a80ad7
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: P21912
name: SDHB
boundary condition: true
is encoded by: hsa:6390

metaM cysam c
is: CHEBI:58029
is: HMDB02991
initial concentration: 1.0
name: cysteaminium
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM leuleu c
constant: false
initial concentration: 1.0
notes: FORMULA: C12H24N2O3 CHARGE: 0
name: Leucylleucine
type: Species
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/94244
boundary condition: false
initial amount: NaN

metaR HPYRR2x
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000304
fast: false
name: hydroxypyruvate reductase (NADH)
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.2.4
product: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110021#

metaM pail5p hs n
is: CHEBI:57795
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
boundary condition: false
constant: false

metaR r2131
reversible: true
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110021#
modifier: MODEL1310110021#

metaR MGSA
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: methylglyoxal synthase
type: Reaction
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD

metaM lnlc l
has only substance units: false
initial amount: NaN
is: HMDB00673
is: SBO:0000247
boundary condition: false
name: linoleate
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
constant: false
initial concentration: 1.0
is: CHEBI:30245

metaM dcsptn1coa c
type: Species
boundary condition: false
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_7e1ec53a_fd01_4311_a82e_9fabcfa41d64
is: SBO:0000252
constant: false
is encoded by: hsa:T83654
boundary condition: true
initial amount: NaN
name: _T83654_1_c
type: Species
initial concentration: NaN
has only substance units: false

metaR r2332
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
product: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#

metaR RE2269E
fast: false
is version of: http://identifiers.org/ec-code/3.4.21.39
reversible: true
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000176
name: RE2269
modifier: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_af2c4e34_c81c_444f_b336_e8c65a2ec1a3
boundary condition: true
type: Species
has only substance units: false
is: O00337
name: SLC28A1
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:9154
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_79853e86_8ece_49ba_a951_a5a37dcf968c
has only substance units: false
constant: false
initial amount: NaN
is: P49753
type: Species
is encoded by: hsa:10965
initial concentration: NaN
name: ACOT2
boundary condition: true
is: SBO:0000252

metaR r1106
product: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_a83c0b69_14e9_42fe_aeb0_c67d35d442cd
type: Species
initial concentration: NaN
is: P19440
constant: false
name: GGT1
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2678
initial amount: NaN

metaM pheacgln c
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: CHEBI:58310
has only substance units: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
constant: false
is: HMDB06344

metaM phyt2ohcoa x
is: CHEBI:57334
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343
is: SBO:0000247
initial concentration: 1.0
name: 2-hydroxyphytanoyl-CoA(4-)
constant: false
boundary condition: false
is: HMDB01295
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_39a2c916_af14_4745_86c8_8f0807688c5d
type: Species
name: LTA4H
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P09960
is encoded by: hsa:4048
is: SBO:0000252
constant: false
has only substance units: false

metaR r1667
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
is: SBO:0000185
reversible: true
modifier: MODEL1310110021#
name: Y+LAT2 Utilized transport

metaM asn L m
name: L-asparagine
has only substance units: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
is: SBO:0000247
is: HMDB00168
is: CHEBI:17196
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaR UGT1A10r
reversible: true
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.4.1.17
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is: SBO:0000176
fast: false
modifier: MODEL1310110021#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000134

metaR CYTK9n
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (CMP,dCTP),nuclear
reactant: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110021#

metaR r0983
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_eae73d82_52d0_4e89_9257_4b644d54ca92
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: O75521
name: ECI2
has only substance units: false
is encoded by: hsa:10455
type: Species
boundary condition: true

metaM dhf c
boundary condition: false
constant: false
is: C00415
is: HMDB01056
initial amount: NaN
name: 7,8-Dihydrofolate
type: Species
is: CHEBI:57451
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_dc805fb7_4da3_4cd3_8574_ea990a17c9f3
boundary condition: true
is encoded by: hsa:37
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: ACADVL
is: SBO:0000252
initial concentration: NaN
is: P49748

http://identifiers.org/biomodels.db/MODEL1310110021#_fabc1f6e_ba9f_495c_8a2e_27e1a1b65c56
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:4967
boundary condition: true
is: Q02218
initial concentration: NaN
name: OGDH

metaM mi145p c
initial amount: NaN
type: Species
has only substance units: false
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: SBO:0000247
is: CHEBI:203600
is: HMDB01498
boundary condition: false
initial concentration: 1.0
constant: false

metaR r2333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction

metaR GNDer
is: SBO:0000176
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
product: MODEL1310110021#
type: Reaction
reversible: false
kinetic law: MODEL1310110021#
name: phosphogluconate dehydrogenase, endoplasmic reticulum

metaR r0838
reversible: true
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.2.4
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
reactant: MODEL1310110021#
is: SBO:0000185
name: Free diffusion
fast: false
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_6f62c517_18a3_478a_8bd7_b3407424cc76
initial concentration: NaN
type: Species
is: Q5SYN6
has only substance units: false
initial amount: NaN
name: SLC22A3
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:6581

http://identifiers.org/biomodels.db/MODEL1310110021#_b092ef1b_525d_49d2_8190_8f9e2113be20
is: Q308M7
name: ENPP3
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5169
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_023c331b_7deb_4720_9760_e9d434003bfd
has only substance units: false
is encoded by: hsa:LOC647190
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _LOC647190_1_c
constant: false
initial amount: NaN
type: Species

metaR MTHFDm
reversible: true
is version of: http://identifiers.org/ec-code/6.3.4.3
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
product: MODEL1310110021#
is described by: ECO:0000269
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000176

metaM dlnlcgcoa r
type: Species
is: CHEBI:27979
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C03595
has only substance units: false
constant: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

metaM duri c
has only substance units: false
is: C00526
initial concentration: 1.0
is: CHEBI:16450
constant: false
name: Deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00012
is: SBO:0000247

metaM fad c
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
type: Species
is: HMDB01248
is: C00016
name: Flavin adenine dinucleotide oxidized
boundary condition: false
is: CHEBI:16238

http://identifiers.org/biomodels.db/MODEL1310110021#_98e56775_8623_4342_a848_dd768bfedf8c
name: SLC26A3
has only substance units: false
constant: false
is encoded by: hsa:1811
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is: P40879

metaR r1668
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
name: Y+LAT2 Utilized transport
fast: false
type: Reaction
product: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_0b026544_f734_4615_8747_01dfceb0d0da
initial amount: NaN
has only substance units: false
name: SLC33A1
is encoded by: hsa:9197
initial concentration: NaN
constant: false
is: O00400
is: SBO:0000252
boundary condition: true
type: Species

metaR r2133
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2069
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110021#
fast: false
type: Reaction
reactant: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110021#
is described by: ECO:0000000

metaM mi4p D c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
is: HMDB01313
constant: false
is: CHEBI:58469
boundary condition: false
type: Species
name: 1D-myo-inositol 4-phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110021#_f259d685_1778_42b7_b9ff_31550963c698
name: VNN3
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:55350
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false

metaM fol c
initial amount: NaN
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial concentration: 1.0
name: Folate
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaR r1939
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
reversible: false

metaR CBASPte
reversible: true
name: Transport of N-carbamoyl-L-aspartate
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110021#
type: Reaction

metaR r0984
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000185

metaR r1661
is: SBO:0000185
modifier: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_41c1eb06_ddfd_4671_88e1_7507d34259fa
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: IDH2
type: Species
initial concentration: NaN
is: P48735
is encoded by: hsa:3418

metaM man c
boundary condition: false
has only substance units: false
constant: false
is: HMDB00169
is: CHEBI:16024
name: D-Mannose
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
is: SBO:0000247
type: Species

metaR FAOXC2252053m
reactant: MODEL1310110021#
fast: false
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110021#

metaM 3hmbcoa m
has only substance units: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
constant: false
initial concentration: 1.0
is: CHEBI:57312
is: HMDB01356
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)

metaR RE1533M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1533
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
fast: false
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_c3576cb4_2b18_45fc_a594_ec347b5dadb7
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:1644
name: DDC
has only substance units: false
is: Q53Y41
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM udp r
boundary condition: false
initial concentration: 1.0
is: HMDB00295
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:58223
initial amount: NaN
name: UDP
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: C00015

http://identifiers.org/biomodels.db/MODEL1310110021#_5a9ede98_9cb9_40ce_b3cb_17a5766a6927
name: KHK
has only substance units: false
is: Q6IBK2
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3795
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_781415d0_b227_4d74_8d56_cc51ded70222
constant: false
type: Species
has only substance units: false
name: NDUFA8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: B1AM93
is encoded by: hsa:4702

http://identifiers.org/biomodels.db/MODEL1310110021#_e4110263_391c_4a41_95a6_04663530ce6e
constant: false
is: Q5JAM2
has only substance units: false
is encoded by: hsa:211
is: SBO:0000252
name: ALAS1
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaM lnlc r
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: SBO:0000247
type: Species
is: CHEBI:30245
initial concentration: 1.0
constant: false
name: linoleate
initial amount: NaN
is: HMDB00673
boundary condition: false
has only substance units: false

metaM pheacgln e
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58310
is: SBO:0000247
boundary condition: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
has only substance units: false
is: HMDB06344
type: Species

metaR ATPtx
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
name: ATP transporter, peroxisomal
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_da030b6d_ecfa_4804_83d6_7f481aab07b1
initial amount: NaN
is: O95573
is: SBO:0000252
is encoded by: hsa:2181
initial concentration: NaN
name: ACSL3
boundary condition: true
has only substance units: false
constant: false
type: Species

metaR r2334
type: Reaction
reversible: true
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM nadph c
boundary condition: false
initial concentration: 1.0
is: C00005
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: HMDB00221
is: CHEBI:57783
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced

metaM acngalgbside hs g
is: HMDB03406
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16523
boundary condition: false
constant: false
name: sialyl galactosylgloboside
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
is: SBO:0000247

metaM phe L c
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
is: CHEBI:17295
initial amount: NaN
is: HMDB00159
constant: false
name: L-phenylalanine
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

metaR r2132
is: SBO:0000185
fast: false
product: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110021#

metaR GRTTx
fast: false
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.5.1.1
name: geranyltranstransferase
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
modifier: MODEL1310110021#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_2dd337f4_444c_41bf_85e6_3da272446952
is encoded by: hsa:23533
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000297
has part: Q8WYR1
type: Species
name: PIK3R5:PIK3CG
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d8f32923_314b_4de2_a09e_8ddab3f69fc5
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ACSL5
has only substance units: false
initial amount: NaN
is: Q9ULC5
constant: false
is encoded by: hsa:51703

metaM prostgi2 c
has only substance units: false
is: SBO:0000247
name: prostaglandin I2(1-)
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
type: Species
constant: false
boundary condition: false
is: CHEBI:57403
initial concentration: 1.0
initial amount: NaN

metaR TDCHOLAtx
kinetic law: MODEL1310110021#
name: bile acid intracellular transport
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#

metaR r1662
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM phytcoa x
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01359
initial concentration: 1.0
is: CHEBI:57391
has only substance units: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
constant: false
name: phytanoyl-CoA(4-)
initial amount: NaN

metaR FTHFL
product: MODEL1310110021#
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110021#
name: Formate-tetrahydrofolate ligase
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM Rtotal2 c
constant: false
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial amount: NaN
type: Species
is: C00055
is: CHEBI:60377
is: HMDB00095
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM pristanal c
type: Species
is: HMDB01958
initial amount: NaN
initial concentration: 1.0
constant: false
name: pristanal
is: CHEBI:49189
has only substance units: false
notes: FORMULA: C19H38O CHARGE: 0 INCHI: InChI=1S/C19H38O/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20/h15-19H,6-14H2,1-5H3
boundary condition: false
is: SBO:0000247

metaM fad e
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
has only substance units: false
is: HMDB01248
initial concentration: 1.0
is: C00016
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
is: CHEBI:16238
boundary condition: false

metaR r0311
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
reversible: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110021#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_428b91f4_25fc_4686_8da4_3539559084c8
has only substance units: false
initial concentration: NaN
is encoded by: hsa:BF195998
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: _BF195998_1_x

metaR r1109
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
type: Reaction
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_a08d3909_90f5_45ab_a3c7_1ab3f52bb4e6
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q96RV2
constant: false
initial concentration: NaN
name: HAS3
boundary condition: true
type: Species
is encoded by: hsa:3038

metaM fol e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
type: Species
constant: false
is: HMDB00121
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_c9b7f768_263c_4b7a_a04f_fd9a417fbb4b
name: QDPR
constant: false
boundary condition: true
is: P09417
is encoded by: hsa:5860
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM eitetcoa m
is: HMDB06294
constant: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
name: 5,8,11,14-eicosatetraenoylcoa
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_60295fc1_a724_4669_bcc0_e996e8d3d616
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: P18405
constant: false
name: SRD5A1
is encoded by: hsa:6715

metaR PAIL4P HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
reactant: MODEL1310110021#
reversible: true
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110021#

metaR r2335
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
reversible: true
is: SBO:0000185

metaR NDPK6m
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
modifier: MODEL1310110021#
reversible: true
fast: false
is described by: ECO:0000254
kinetic law: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

http://identifiers.org/biomodels.db/MODEL1310110021#_665f0af7_daef_451f_a3ba_315d18278508
boundary condition: true
name: ELOVL6
type: Species
constant: false
is: Q9H5J4
has only substance units: false
is encoded by: hsa:79071
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_cdd24d5c_5c90_4de5_9c1d_b16907828da9
type: Species
name: IDI2
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:91734
boundary condition: true
constant: false
initial concentration: NaN
is: Q9BXS1

metaR RE1903R
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
name: RE1903
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_903e883d_4678_4529_bb02_a99241b722ce
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: _F23536_1_m
initial amount: NaN
is encoded by: hsa:F23536
constant: false
boundary condition: true

metaR r0986
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Vesicular transport

metaR r1937
kinetic law: MODEL1310110021#
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#

metaM man e
is: HMDB00169
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:16024
initial concentration: 1.0
name: D-Mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: C00159
is: SBO:0000247
constant: false
type: Species

metaM utp e
name: UTP(4-)
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:46398
is: HMDB00285

metaR RE0690E
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110021#
reversible: false
is described by: ECO:0000000
type: Reaction
name: RE0690
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110021#

metaR NAt3 1
name: sodium proton antiporter (H:NA is 1:1)
modifier: MODEL1310110021#
fast: false
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR

metaM na1 r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial amount: NaN
constant: false
is: HMDB00588
is: CHEBI:29101
is: SBO:0000247
boundary condition: false
name: sodium(1+)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_b0d135cc_24c7_4684_a241_b8c7afc4d0e4
initial concentration: NaN
name: SLC25A26
type: Species
is: Q70HW3
has only substance units: false
is encoded by: hsa:115286
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaR SIAT4Bg
modifier: MODEL1310110021#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
kinetic law: MODEL1310110021#
fast: false
type: Reaction
product: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110021#_78817c93_bfc9_4b7b_99ee_0faf0f782356
is encoded by: hsa:55825
initial amount: NaN
constant: false
name: PECR
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: Q9BY49

http://identifiers.org/biomodels.db/MODEL1310110021#_0bbfcd19_da9c_4ae7_a250_f4674202e439
is encoded by: hsa:8525
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: DGKZ
has only substance units: false
type: Species
is: SBO:0000252
is: G3V0F6

metaR DMNONCRNCPT2
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
type: Reaction
name: DMNONCRNCPT2
fast: false
is described by: ECO:0000000

metaM 3ohdcoa x
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: CHEBI:57349
is: HMDB06402
has only substance units: false
name: 3-oxopalmitoyl-CoA(4-)
is: SBO:0000247

metaR NDPK6n
reactant: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110021#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true

metaM ditp c
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: HMDB03537
is: CHEBI:61382
boundary condition: false
name: dITP(4-)
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR 7DHCHSTEROLtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
kinetic law: MODEL1310110021#
is: SBO:0000185
name: cholesterol precursor intracellular transport
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
fast: false

metaR r0987
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110021#
is: SBO:0000185
reversible: true
name: Vesicular transport
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_2feec3ae_4d27_45d1_a29a_9327df122591
initial amount: NaN
name: PPA2
is: F8WDN9
has only substance units: false
is encoded by: hsa:27068
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaR DHCR71r
fast: false
product: MODEL1310110021#
name: 7-dehydrocholesterol reductase
kinetic law: MODEL1310110021#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.21
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ

metaM prostgh2 e
is: HMDB01381
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57405
has only substance units: false
boundary condition: false
constant: false
name: prostaglandin H2(1-)

metaR ACHtn
type: Reaction
reversible: true
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
kinetic law: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110021#
name: Acetylcholin transport, nuclear trhough pores

metaR ILEPHELAT2tc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Isoleucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR r0834
is version of: http://identifiers.org/ec-code/3.5.4.16
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110021#

metaR HIStN1
name: Histidine transport (Na, H coupled)
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000269
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_5a8d4f4d_964f_497b_a88d_35607d9f9e27
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:3177
name: SLC29A2
initial concentration: NaN
is: Q14542

metaR CYTDK1
modifier: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.48
name: ATPcytidine 5-phosphotransferase
type: Reaction
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000254
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaR PPAm
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reversible: false
modifier: MODEL1310110021#
product: MODEL1310110021#
name: inorganic diphosphatase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110021#

metaR FPGS6m
name: folylpolyglutamate synthetase (DHF), mitochondrial
type: Reaction
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
reversible: false
fast: false
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.3.2.17

http://identifiers.org/biomodels.db/MODEL1310110021#_80c74f38_0a39_4d69_a9d9_f2aea1950917
is: Q8N695
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC5A8
type: Species
is encoded by: hsa:160728
boundary condition: true
constant: false
initial concentration: NaN

metaR r1664
product: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
name: Y+LAT2 Utilized transport
type: Reaction

metaM pro L m
is: HMDB00162
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
name: L-proline
initial concentration: 1.0
boundary condition: false
is: CHEBI:17203
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_579445ca_e203_42eb_a299_fee6e2c5f06f
has part: O15254
constant: false
boundary condition: true
initial amount: NaN
type: Species
has part: Q9NY65
has only substance units: false
is encoded by: hsa:1962
is encoded by: hsa:8310
initial concentration: NaN
is: SBO:0000297
name: EHHADH:ACAA1:HSD17B4:ACOX3

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_49135b59_3724_45e3_96af_147c48ae9f9d
is: B4DZR2
is encoded by: hsa:8854
type: Species
boundary condition: true
name: ALDH1A2
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_b7674e09_0e90_46d1_bf05_cb54df659774
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AI469183_1_x
is encoded by: hsa:AI469183
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_eca29fef_aec8_4384_9498_880f466973af
constant: false
has only substance units: false
is encoded by: hsa:8503
is: SBO:0000252
is: Q92569
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PIK3R3
type: Species

metaR GCC2cm
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.1.2.10
is: SBO:0000176
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
reversible: true
product: MODEL1310110021#
fast: false
type: Reaction
name: glycine-cleavage complex (lipoamide), mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110021#_52089825_48f8_48e7_a2a5_7e30d4f6fd34
has only substance units: false
name: LDHA
boundary condition: true
is encoded by: hsa:3939
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is: P00338
initial concentration: NaN

metaM xoltriol m
type: Species
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
is: HMDB01457
boundary condition: false
constant: false
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial amount: NaN
has only substance units: false
is: CHEBI:16496

metaM duri n
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 2'-deoxyuridine
initial concentration: 1.0
has only substance units: false
is: CHEBI:16450
constant: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
type: Species
is: HMDB00012

metaR r2338
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
product: MODEL1310110021#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_6274db3e_5947_4af4_a97e_669c7566c78c
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR LNLCCRNt
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
is: SBO:0000185
name: transport into the mitochondria (carnitine)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_ae1ef6af_0585_4dd5_9bb4_acafddd50d56
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:26503
is: Q9NRA2
initial amount: NaN
name: SLC17A5
type: Species
constant: false

metaR UMPK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dGTP)
fast: false
modifier: MODEL1310110021#

metaM r5p c
is: CHEBI:18189
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
is: SBO:0000247
type: Species
name: alpha-D-Ribose 5-phosphate
is: HMDB00618
initial concentration: 1.0
constant: false
is: C00117
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_b8c62777_6dd3_4953_8912_b7e32413567a
type: Species
has only substance units: false
name: OXCT1
is encoded by: hsa:5019
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P55809
constant: false

metaM C04849 e
boundary condition: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
is: CHEBI:57449
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_dce5b4c8_1199_49b8_8f63_0ba371f1ee54
is encoded by: hsa:3098
initial concentration: NaN
name: HK1
is: SBO:0000252
boundary condition: true
is: Q59FD4
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR RE0344C
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110021#
name: RE0344
fast: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#

metaM dcsptn1coa m
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
is: HMDB06513
initial amount: NaN
boundary condition: false
constant: false
type: Species
has only substance units: false
is: C16173
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247

metaM utp c
is: SBO:0000247
initial amount: NaN
name: UTP
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
has only substance units: false
is: CHEBI:46398
constant: false
is: HMDB00285
is: C00075
boundary condition: false
initial concentration: 1.0

metaR PPAn
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#
name: inorganic diphosphatase, nuclear
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: 3.6.1.1 Confidence Level: 1 AUTHORS: NOTES:

metaR r0629
type: Reaction
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.4.1
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.22
modifier: MODEL1310110021#

metaR ACGALtly
name: N-acetyl-galactosamine lysosomal efflux
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110021#
product: MODEL1310110021#

metaM 3ohdcoa m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: CHEBI:57349
constant: false
is: HMDB06402
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 3-oxopalmitoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110021#_69574735_b268_4a08_96c9_f6a1cf210ed6
has only substance units: false
constant: false
name: SLC26A2
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1836
is: P50443
boundary condition: true

metaR UMPK6
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: UMP kinase (dCTP)
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000269
kinetic law: MODEL1310110021#

metaR r0774
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110021#
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is described by: ECO:0000000
fast: false
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110021#

metaR O2tp
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
name: O2 transport, peroxisomal
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_56861eda_5560_4fbe_8600_4581eeca59d3
is encoded by: hsa:113026
is: Q8N3E9
name: PLCD3
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaM f6p c
initial amount: NaN
is: SBO:0000247
constant: false
name: D-Fructose 6-phosphate
is: http://identifiers.org/pubchem.compound/3385
is: CHEBI:57579
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00124
is: C00085
boundary condition: false

metaM duri m
initial amount: NaN
is: HMDB00012
name: 2'-deoxyuridine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
boundary condition: false
constant: false
type: Species
initial concentration: 1.0

metaM datp c
type: Species
name: dATP
is: C00131
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01532
constant: false
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
boundary condition: false

metaR RE1522M
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1522
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
modifier: MODEL1310110021#

metaM 4nph e
name: 4-nitrophenolate
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01232
has only substance units: false
constant: false
type: Species
is: CHEBI:57917

metaR RETI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinol isomerase (9-cis)
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true

metaR r0202
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
kinetic law: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
reactant: MODEL1310110021#

metaM 7dhchsterol r
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: HMDB00032
is: CHEBI:17759
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial amount: NaN
name: cholesta-5,7-dien-3beta-ol
boundary condition: false

metaR r0295
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
modifier: MODEL1310110021#
reversible: false

metaM aacoa x
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
has only substance units: false
constant: false
name: acetoacetyl-CoA(4-)
is: HMDB01484
is: SBO:0000247
is: CHEBI:57286
type: Species
initial amount: NaN
initial concentration: 1.0

metaM mn l
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB06535
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
name: beta-1,4-mannose-N-acetylglucosamine
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_37909588_7cd3_4a96_b270_8c34fa30aca5
initial amount: NaN
is: SBO:0000252
name: COX6A2
initial concentration: NaN
is encoded by: hsa:1339
constant: false
is: Q02221
has only substance units: false
type: Species
boundary condition: true

metaM chsterol c
has only substance units: false
name: cholesterol
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: SBO:0000247
boundary condition: false
is: CHEBI:16113
type: Species
is: HMDB00067
initial amount: NaN
constant: false

metaM HC02205 e
is: SBO:0000247
is: CHEBI:28099
type: Species
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
name: prostaglandin-b2
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

http://identifiers.org/biomodels.db/MODEL1310110021#_708b1822_b41e_4ada_b3f0_ed86a65293c8
type: Species
is: SBO:0000252
is: P14410
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6476
constant: false
boundary condition: true
name: SI
initial amount: NaN

metaM asn L c
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
initial concentration: 1.0
name: L-asparagine
is: HMDB00168

metaR NMNATr
reversible: true
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1
is described by: ECO:0000269
product: MODEL1310110021#
name: nicotinamide-nucleotide adenylyltransferase

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaM msa m
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
is: SBO:0000247
is: HMDB11111
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:33190
name: 3-oxopropanoate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_3e34f32b_c699_4f23_988a_e335c304587e
boundary condition: true
initial concentration: NaN
name: HAGH
constant: false
is: SBO:0000252
is: Q16775
is encoded by: hsa:3029
type: Species
initial amount: NaN
has only substance units: false

metaM hmgcoa c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
type: Species
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

http://identifiers.org/biomodels.db/MODEL1310110021#_8881942f_6d20_4394_9b70_6630012d51ec
initial concentration: NaN
has only substance units: false
is: B3KVI7
constant: false
initial amount: NaN
is encoded by: hsa:3712
is: SBO:0000252
name: IVD
type: Species
boundary condition: true

metaM ala L e
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16977
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
type: Species
constant: false
is: HMDB00161

metaM dhf m
is: HMDB01056
constant: false
initial amount: NaN
is: CHEBI:57451
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0
type: Species
name: dihydrofolate(2-)
has only substance units: false

metaR RETI1
is described by: ECO:0000000
kinetic law: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
type: Reaction
name: retinol isomerase (11-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110021#
reversible: true
fast: false

metaM gluside hs c
initial amount: NaN
is: CHEBI:18368
type: Species
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c1360f20_e5ba_4640_a416_4bdd90392535
name: SLC26A1
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:10861
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaR RE2626M
product: MODEL1310110021#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
name: RE2626
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reversible: true
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_ed739e95_688f_4c53_b540_b4563c81e7e8
has only substance units: false
boundary condition: true
is: P11509
is encoded by: hsa:1548
is: SBO:0000252
name: CYP2A6
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM nh4 x
name: Ammonium
constant: false
initial concentration: 1.0
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C01342
type: Species

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaR r2063
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#

metaM lys L x
name: L-lysinium(1+)
type: Species
is: HMDB00182
is: CHEBI:32551
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM ctp n
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
initial amount: NaN
is: CHEBI:37563
initial concentration: 1.0
is: SBO:0000247
name: CTP(4-)
is: HMDB00082
has only substance units: false
type: Species

metaM 4mzym int2 r
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB06838
initial concentration: 1.0
type: Species
name: 4-Methylzymosterol intermediate 2
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1
boundary condition: false
initial amount: NaN

metaR UMPK4
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110021#
product: MODEL1310110021#
name: UMP kinase (GTP)
kinetic law: MODEL1310110021#
is described by: ECO:0000269

metaR FE2DMT1
reversible: false
product: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
modifier: MODEL1310110021#
name: uptake of food iron by DMT1 transporter
fast: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (4891.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
kinetic law: MODEL1310110021#

metaR CSPG Ctly
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: chondroitin sulfate C transport, extracellular to lysosome
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1bd155b4_076e_46bf_a3c8_9d179e36874e
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q86XP1
boundary condition: true
type: Species
name: DGKH
constant: false
has only substance units: false
is encoded by: hsa:160851

metaM dhf l
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: dihydrofolate(2-)
is: SBO:0000247
type: Species
is: HMDB01056
is: CHEBI:57451

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM h2o r
constant: false
initial concentration: 1.0
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
type: Species
name: H2O
initial amount: NaN
is: HMDB02111
is: C00001
is: SBO:0000247
has only substance units: false

metaR RE3565C
name: RE3565
reversible: true
product: MODEL1310110021#
type: Reaction
fast: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_673216af_d00e_47b7_9c5a_3accc5b3e667
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:48
is: SBO:0000252
boundary condition: true
is: P21399
initial amount: NaN
type: Species
name: ACO1

metaM HC02205 c
has only substance units: false
is: SBO:0000247
is: CHEBI:28099
boundary condition: false
type: Species
name: prostaglandin-b2
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

metaM 2hb c
is: CHEBI:1148
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00008
name: 2-Hydroxybutyrate
type: Species
constant: false

metaR PGLYCt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
type: Reaction
name: phosphatidylglycerol transport
kinetic law: MODEL1310110021#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR r0830
reactant: MODEL1310110021#
is: SBO:0000185
fast: false
modifier: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16

metaR r1660
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_69e99f10_8ccd_4efd_8e7d_9b4dfbb95054
name: COX6B2
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q6YFQ2
constant: false
is encoded by: hsa:125965
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_9650d84a_cbce_4c74_ad82_c344602fd834
type: Species
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: _728226_1_m
is encoded by: hsa:728226

metaM 2mp2coa m
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01011
has only substance units: false
is: SBO:0000247
name: 2-Methylprop-2-enoyl-CoA
is: CHEBI:27754
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
type: Species
boundary condition: false

metaM asn L e
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:17196
type: Species
has only substance units: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
initial concentration: 1.0
name: L-asparagine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_762a75d6_fa40_43d5_a1b2_d54508e5719c
name: PISD
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is: Q9UG56
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23761

metaR 5MTAte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-S-methyl-5-thioadenosine
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000134
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
reversible: true

metaR UMPK5
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
name: UMP kinase (dATP)
fast: false
reactant: MODEL1310110021#

metaR HSD3A2r
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
modifier: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_5f288b1c_2aec_402d_b0c7_9af5420c4891
name: PIK3R1
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:5295
is: SBO:0000252
initial concentration: NaN
constant: false
is: E7EX19

metaM HC00229 e
has only substance units: false
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
boundary condition: false
is: CHEBI:28189
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Isomaltose

http://identifiers.org/biomodels.db/MODEL1310110021#_2157ec04_3dcb_4b30_8ab3_a68225028fc1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: INPP5J
type: Species
constant: false
has only substance units: false
is encoded by: hsa:27124

http://identifiers.org/biomodels.db/MODEL1310110021#_602764c4_ae55_4175_96ac_c4b2220acc47
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:8560
type: Species
name: DEGS1
initial amount: NaN
boundary condition: true

metaM CE4792 m
is: SBO:0000247
name: 3-oxo-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false

metaR r0698
is version of: http://identifiers.org/ec-code/3.1.2.27
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_1ba4209e_b4ac_4735_860f_6f09039462f6
type: Species
is: SBO:0000252
name: _AV717590_1_c
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AV717590
initial amount: NaN

metaR SAMHISTA
modifier: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.8
type: Reaction
fast: false

metaR MANt1r
fast: false
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
name: mannose transport (uniport)

metaR r0552
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000000
modifier: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
reversible: true
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is: SBO:0000176
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR CRNrtx
reactant: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
reversible: true
is: SBO:0000185
name: reversible transport of L-Carnitine in peroxisome
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000134

metaR RE0958E
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110021#
name: RE0958
type: Reaction
reversible: true
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_27e46a6e_c48d_47cf_9b30_2e54e6fe20a7
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
type: Species
name: HADHA:HADHB
has part: E9KL44
is encoded by: hsa:3032
constant: false
is encoded by: hsa:3030
boundary condition: true
has only substance units: false
has part: P55084

metaM fol m
is: HMDB00121
type: Species
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:27470
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
initial concentration: 1.0
name: Folate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_96f86ecd_19f8_45b9_a18f_eb9147f0610c
is: Q1EHB4
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:159963
initial concentration: NaN
constant: false
name: SLC5A12
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_289d055b_96bc_4f3c_bb36_53088e6eaca3
type: Species
name: GOT1
is encoded by: hsa:2805
is: P17174
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_05ca09c8_ffcd_4d3e_a588_9e268ce22cf5
is: Q9NWU1
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54995
initial amount: NaN
name: OXSM
type: Species

metaM pro L c
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
initial amount: NaN
name: L-proline
initial concentration: 1.0
has only substance units: false
is: CHEBI:17203

http://identifiers.org/biomodels.db/MODEL1310110021#_2d55110e_3951_4867_ad32_e823a7ccdd31
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: KDSR
is: Q06136
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2531

metaM h2o l
name: water
constant: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
initial amount: NaN
boundary condition: false
is: HMDB02111
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:15377

metaM fad m
is: HMDB01248
initial concentration: 1.0
is: SBO:0000247
is: C00016
name: Flavin adenine dinucleotide oxidized
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16238
constant: false
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

metaR XOL7AONEtr
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
reversible: true
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#

metaM ala L c
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
initial amount: NaN
is: CHEBI:16977
boundary condition: false
is: HMDB00161
type: Species
has only substance units: false

metaR r0553
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110021#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR r0779
product: MODEL1310110021#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
reversible: false
fast: false
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110021#_d8029611_f5cc_419a_b6ea_3464c8a2afd1
is encoded by: hsa:570
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: Q14032
initial concentration: NaN
initial amount: NaN
name: BAAT

metaM man l
name: D-mannose
has only substance units: false
initial amount: NaN
is: HMDB00169
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
is: CHEBI:16024
constant: false
initial concentration: 1.0

metaR FATP2t
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: fatty acid electroneutral transport
type: Reaction
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_30bb8b8b_a280_4046_bf26_3764688c00ef
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: AICDA
is: Q546Y9
is encoded by: hsa:57379
constant: false

metaM sT antigen g
type: Species
has only substance units: false
is: CHEBI:16565
boundary condition: false
notes: FORMULA: C25H40N2O18X CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
constant: false
name: sialyl-T antigen
initial amount: NaN

metaR ADNt
kinetic law: MODEL1310110021#
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
product: MODEL1310110021#
fast: false
is described by: ECO:0000269
name: adenosine facilated transport in cytosol
reactant: MODEL1310110021#

metaM nadph m
is: CHEBI:57783
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
initial concentration: 1.0
is: HMDB00221
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_79887347_f769_4cbd_9dab_8b6915136bc3
is: A6NN98
name: MTMR2
constant: false
is encoded by: hsa:8898
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM gullac c
name: L-gulono-1,4-lactone
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
is: HMDB03466
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:17587
initial amount: NaN
boundary condition: false

metaR DATPtm
is: SBO:0000185
name: transport of dATP into mitochondria
product: MODEL1310110021#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reversible: false
fast: false

metaR PPAt
is: SBO:0000185
product: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
fast: false
name: Propionate transport, diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
reactant: MODEL1310110021#
is described by: ECO:0000000

metaM hedepecoa m
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
is: HMDB02288
name: 2,4,7,10,13-hexadecapentenoylcoa
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1c623708_2dc4_43d1_9b1c_0e2d556170e3
type: Species
constant: false
name: SLC24A2
boundary condition: true
initial amount: NaN
is: Q9UI40
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:25769

metaM h2o m
boundary condition: false
is: HMDB02111
constant: false
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
type: Species
name: H2O
initial concentration: 1.0
is: CHEBI:15377
is: C00001
is: SBO:0000247

metaM gbside hs g
type: Species
is: SBO:0000247
is: CHEBI:18259
initial amount: NaN
name: globoside
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0

metaM betald c
is: SBO:0000247
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
initial concentration: 1.0
is: HMDB01252
constant: false
name: betaine aldehyde
is: CHEBI:15710
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_f50d3997_8bdb_4a8b_b856_012fa720d073
is: SBO:0000252
is encoded by: hsa:125
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: ADH1B
is: P00325
type: Species

metaM crn x
has only substance units: false
is: CHEBI:16347
is: HMDB00062
type: Species
name: L-Carnitine
is: SBO:0000247
constant: false
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM amet m
is: CHEBI:15414
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
name: S-Adenosyl-L-methionine
is: C00019
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01185

metaR NPTHLte
is: SBO:0000185
name: xenobiotic transport
type: Reaction
kinetic law: MODEL1310110021#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#

metaR CLS hs
name: cardiolipin synthase (homo sapiens)
reversible: false
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_6659f80f_5e16_4823_b3b2_01c913314948
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: ADHFE1
is: Q8IWW8
has only substance units: false
is encoded by: hsa:137872
is: SBO:0000252
initial concentration: NaN

metaM gluside hs g
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: SBO:0000247
initial amount: NaN

metaR UMPK6n
product: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000176
name: UMP kinase (dCTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_577eab5b_8114_4b15_8c3b_81713af870b2
name: ACAD11
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:84129
is: Q709F0
is: SBO:0000252

metaR r0627
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
kinetic law: MODEL1310110021#
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
product: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_ed026e08_6b91_4389_b32c_800edd367ad3
initial amount: NaN
name: MYO5B
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9H6Y6
boundary condition: true
is encoded by: hsa:4645

http://identifiers.org/biomodels.db/MODEL1310110021#_db69906b_b3b0_4f56_97ad_b3cc30ff0217
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q16831
constant: false
boundary condition: true
has only substance units: false
name: UPP1
is encoded by: hsa:7378

metaR MACOXO
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110021#
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.4.3.4

metaR RTOTALt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: RTOTAL transport
type: Reaction
product: MODEL1310110021#

metaR DATPtn
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
name: dATP diffusion in nucleus
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110021#

metaM h2o n
initial amount: NaN
type: Species
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
boundary condition: false
is: HMDB02111
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15377
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c1d62fd6_3a89_4b91_8657_a1321085ca0c
is: Q96T66
is: SBO:0000252
name: NMNAT3
has only substance units: false
is encoded by: hsa:349565
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaM pro L e
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00162
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
name: L-proline
initial concentration: 1.0
is: CHEBI:17203
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_0ba055c1_e7d9_4dff_a3ad_b915b2fb95e3
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: GALT
is encoded by: hsa:2592
is: SBO:0000252
is: B4E097

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaR DADNt4
name: deoxyadenosine transport via diffusion
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000

metaM sphgn c
type: Species
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
boundary condition: false
is: SBO:0000247
name: sphinganine(1+)
is: HMDB00269
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57817

http://identifiers.org/biomodels.db/MODEL1310110021#_16e6a0a3_b489_4d1f_b667_86ddb7e9fe87
name: B3GALT5
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10317

http://identifiers.org/biomodels.db/MODEL1310110021#_fd6ed6d8_300b_4773_92b2_f8b6f0b9d54c
boundary condition: true
constant: false
name: NDUFB3
is: SBO:0000252
is encoded by: hsa:4709
is: Q6IB80
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaM chsterol e
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: cholesterol
type: Species
is: HMDB00067

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM 56dthm m
constant: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
is: SBO:0000247
has only substance units: false
name: 5,6-dihydrothymine
initial amount: NaN
is: HMDB00079
boundary condition: false
type: Species
is: CHEBI:27468
initial concentration: 1.0

metaM HC01410 m
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:28706
constant: false
initial concentration: 1.0
name: (2E)-Hexenoyl-CoA
is: SBO:0000247

metaR AHCYStd
name: diffusion of S-Adenosyl-L-homocysteine
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
reactant: MODEL1310110021#

metaM 2hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB02288
name: 2,7,10,13-hexadecatetraenoylcoa

metaM pac c
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial concentration: 1.0
constant: false
type: Species
is: HMDB00209
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:18401
name: phenylacetate

metaR MEOHt2
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
name: Methanol diffusion
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM dpcoa c
initial concentration: 1.0
name: Dephospho-CoA
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01373
is: C00882
constant: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328

metaM nadh r
is: CHEBI:57945
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: HMDB01487
name: NADH(2-)
initial amount: NaN
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: SBO:0000247
has only substance units: false

metaM hmgcoa m
initial amount: NaN
is: HMDB01375
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:15467
initial concentration: 1.0
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
constant: false
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA

metaM tdchola e
is: SBO:0000247
constant: false
is: CHEBI:9407
type: Species
initial concentration: 1.0
name: taurochenodeoxycholate
boundary condition: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
is: HMDB00951
has only substance units: false

metaR ACETONEt2m
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
name: acetone mitochondrial transport via proton symport
kinetic law: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
reversible: true
type: Reaction
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_60cbb740_8b25_4a06_a310_09d1acab0f0e
name: CHKA
is encoded by: hsa:1119
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_24c78e22_eaf9_4690_93a0_a4a89d540907
type: Species
has only substance units: false
name: ATP2B2
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: Q4J699
is encoded by: hsa:491
is: SBO:0000252

metaR FAOXC226C225m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_1484cadd_7d35_4791_8704_c0db2d7c1bc8
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is: E9KL44
name: HADHA
initial concentration: NaN
type: Species
is encoded by: hsa:3030

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_03727ab8_b0d0_4c48_8f69_e00efae3985e
initial amount: NaN
is: B4DER4
is encoded by: hsa:5291
name: PIK3CB
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaR ONPTHLte
fast: false
name: xenobiotic transport
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_feaeb836_b0a4_442e_96e0_ce9e218aa7b1
type: Species
name: ACOT1
constant: false
has only substance units: false
is: E9KL42
is: SBO:0000252
is encoded by: hsa:641371
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM dcyt n
boundary condition: false
has only substance units: false
name: 2'-deoxycytidine
constant: false
initial amount: NaN
is: CHEBI:15698
type: Species
is: SBO:0000247
is: HMDB00014
initial concentration: 1.0
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaR AHCYSte
is: SBO:0000185
name: Transport of S-adenosyl-L-homocysteine
reactant: MODEL1310110021#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110021#_cd4846fc_ae9c_479d_a3ad_e6b7714b0750
is encoded by: hsa:3098
initial amount: NaN
name: HK1
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
is: A8K7J7

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR FAS140COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
name: fatty-acyl-CoA synthase (n-C14:0CoA)
product: MODEL1310110021#
type: Reaction
reversible: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000269
fast: false

metaM glx c
initial amount: NaN
is: CHEBI:36655
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00119
boundary condition: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
type: Species
has only substance units: false
name: glyoxylate

http://identifiers.org/biomodels.db/MODEL1310110021#_8fead2eb_e4f6_4612_bcee_4d3f7fd417c0
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P15104
boundary condition: true
type: Species
constant: false
name: GLUL
is encoded by: hsa:2752

http://identifiers.org/biomodels.db/MODEL1310110021#_89feb50b_39fd_4c0b_84e8_efdd838e4026
has only substance units: false
name: NME1
type: Species
constant: false
boundary condition: true
is encoded by: hsa:4830
is: SBO:0000252
initial amount: NaN
is: P15531
initial concentration: NaN

metaM dpcoa e
initial concentration: 1.0
initial amount: NaN
type: Species
name: Dephospho-CoA
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: HMDB01373
is: C00882
is: CHEBI:57328
notes: FORMULA: C21H33N7O13P2S CHARGE: -2

metaM ser L m
type: Species
name: L-serine
has only substance units: false
is: CHEBI:17115
boundary condition: false
is: SBO:0000247
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false
initial amount: NaN
initial concentration: 1.0

metaR r0545
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
reversible: true
is described by: ECO:0000000

metaM tdchola c
type: Species
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:9407
initial concentration: 1.0
name: taurochenodeoxycholate
is: HMDB00951
initial amount: NaN

metaM bilirub e
constant: false
is: HMDB00054
is: CHEBI:57977
has only substance units: false
initial concentration: 1.0
name: bilirubin(2-)
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
boundary condition: false
type: Species

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_07c1da5c_dda9_44de_b1ab_e3affc9e85f4
has only substance units: false
boundary condition: true
is encoded by: hsa:80271
initial concentration: NaN
constant: false
name: ITPKC
type: Species
initial amount: NaN
is: Q96DU7
is: SBO:0000252

metaM n2m2nm l
boundary condition: false
notes: FORMULA: C58H97N5O41 CHARGE: 0
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
name: n2m2nmasn (w/o peptide linkage)
has only substance units: false
is: HMDB01356
is: CHEBI:57312

metaM dec47dicoa m
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
initial amount: NaN
name: 4,7-decadienoylcoa
boundary condition: false

metaM mercppyr c
boundary condition: false
initial amount: NaN
is: CHEBI:57678
initial concentration: 1.0
is: HMDB01368
constant: false
name: 3-mercaptopyruvate
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_dd5681f8_f03e_44e1_ba75_fc9e46b1ca3b
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:81031
constant: false
name: SLC2A10
is: O95528
is: SBO:0000252
initial concentration: NaN

metaM vitd3 e
boundary condition: false
type: Species
is: HMDB00876
name: calciol
is: CHEBI:28940
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_083c74b1_16c9_47cf_b4f3_f51217d46d17
type: Species
has only substance units: false
is: O15269
name: SPTLC1
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10558
is: SBO:0000252
boundary condition: true

metaR TSTSTERONEt
reactant: MODEL1310110021#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
name: Testosterone transport

metaR r0488
fast: false
type: Reaction
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reversible: true
product: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR GTHOm
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000254
name: glutathione oxidoreductase
modifier: MODEL1310110021#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.7
fast: false
product: MODEL1310110021#

metaR BTNPLm
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_0be04675_4962_4b1a_b56f_d3ff4328f984
initial amount: NaN
has only substance units: false
is encoded by: hsa:389015
initial concentration: NaN
constant: false
type: Species
is: Q6AI14
boundary condition: true
is: SBO:0000252
name: SLC9A4

metaM arachd e
initial concentration: 1.0
is: HMDB01043
type: Species
constant: false
boundary condition: false
name: arachidonate
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395

http://identifiers.org/biomodels.db/MODEL1310110021#_69ba4190_b524_43db_a8b1_fb15eca3f53c
name: ACSL1
initial amount: NaN
is: P33121
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:2180

metaR r1540
reactant: MODEL1310110021#
type: Reaction
reversible: false
kinetic law: MODEL1310110021#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is described by: ECO:0000000

metaM prist c
boundary condition: false
is: HMDB00795
constant: false
is: CHEBI:51340
type: Species
name: pristanic acid
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)

metaM dad 2 e
boundary condition: false
has only substance units: false
is: HMDB00101
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial amount: NaN
name: 2-deoxyadenosine
is: CHEBI:17256
initial concentration: 1.0

metaR GTHRDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
name: Glutathione transport into mitochondria
reversible: true
fast: false

metaM r1p c
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: C00442
initial concentration: 1.0
is: HMDB01489
name: alpha-D-Ribose 1-phosphate
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57720
type: Species
constant: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_e9d04a89_7d4b_4001_a568_376df976b4a0
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55349
is: Q8NE62
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: CHDH
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_42aeeb05_d8f2_4b9d_948a_af10454741cc
boundary condition: true
has only substance units: false
constant: false
name: GRHPR
is: Q9UBQ7
initial concentration: NaN
is encoded by: hsa:9380
is: SBO:0000252
type: Species
initial amount: NaN

metaM onpthl c
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB06215
has only substance units: false
name: naphthalene epoxide
notes: FORMULA: C10H8O CHARGE: 0 INCHI: InChI=1/C10H8O/c1-2-4-8-7(3-1)5-6-9-10(8)11-9/h1-6,9-10H
boundary condition: false

metaM octe5coa m
type: Species
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
initial amount: NaN
name: 5-octenoylcoa
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

metaR SPH1Pte
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#
type: Reaction
name: sph1p transport
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_860b8563_bfbf_403e_9083_18443fa14249
is: SBO:0000252
is encoded by: hsa:83715
has only substance units: false
constant: false
initial amount: NaN
is: B1AK53
initial concentration: NaN
type: Species
boundary condition: true
name: ESPN

metaM HC01609 e
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
name: UroporphyrinogenI
type: Species
is: CHEBI:28766
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_8e1b8e09_fa99_4485_af53_a91bf3bea43c
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:1349
initial amount: NaN
is: P24311
initial concentration: NaN
constant: false
is: SBO:0000252
name: COX7B

metaM pail35p hs c
constant: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57923
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_8be0ad0a_2d12_40b3_9afc_22d5b5efcbaf
name: PRPS2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P11908
initial amount: NaN
type: Species
is encoded by: hsa:5634
boundary condition: true
constant: false

metaM bilirub c
is: CHEBI:57977
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
is: HMDB00054
name: bilirubin(2-)
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false

metaM pe hs r
name: phosphatidylethanolamine
is: CHEBI:16038
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0

metaM thmpp m
has only substance units: false
constant: false
is: SBO:0000247
type: Species
is: HMDB01372
boundary condition: false
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: CHEBI:45931
name: Thiamine diphosphate
initial amount: NaN
initial concentration: 1.0

metaR 3MLDAt
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110021#
name: 3MLDA extracellular transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#

metaM cspg c e
boundary condition: false
is: C00106
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
has only substance units: false
is: SBO:0000247
is: HMDB00300
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
is: CHEBI:17568
type: Species

metaM dec24dicoa m
type: Species
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,4-decadienoylcoa
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01168

metaR DHFtm
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: dihydrofolate reversible mitochondrial transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110021#
reversible: true

metaR HACD1m
modifier: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110021#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is described by: ECO:0000134
type: Reaction

metaR SMPD4
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000176
reversible: false
name: sphingomyelinase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000

metaR TDCHOLAte
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
name: bile acid intracellular transport
type: Reaction

metaR r1547
reactant: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR 2HBt2
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000269
name: 2-hydroxybutyrate cotransport with proton
modifier: MODEL1310110021#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#

metaM dad 2 c
has only substance units: false
is: HMDB00101
is: SBO:0000247
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
initial concentration: 1.0
type: Species
name: 2-deoxyadenosine
boundary condition: false
constant: false
is: CHEBI:17256
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_af1b0ba5_efb6_4cbf_b182_70b368ca72b6
initial concentration: NaN
name: SLC5A10
has only substance units: false
boundary condition: true
is: A0PJK1
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:125206
initial amount: NaN

metaR OBDHc
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
fast: false
reversible: false
name: 2-Oxobutanoate dehydrogenase, cytosolic
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR 13DAMPPOX
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
reversible: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.3.21
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
fast: false
modifier: MODEL1310110021#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_6da88566_617f_4af5_ae62_b8279427ed53
initial amount: NaN
is: Q5FWF5
boundary condition: true
is encoded by: hsa:114799
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: ESCO1

http://identifiers.org/biomodels.db/MODEL1310110021#_cf0e7866_d709_431d_887c_1a03e4caa6b8
boundary condition: true
is encoded by: hsa:221823
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: PRPS1L1
is: SBO:0000252
initial amount: NaN

metaM arachd c
type: Species
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: HMDB01043
boundary condition: false
name: arachidonate
is: CHEBI:32395
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM 4ppcys c
is: SBO:0000247
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:59458
has only substance units: false
constant: false
is: HMDB01117
initial amount: NaN
is: C04352

metaM udp c
type: Species
is: C00015
has only substance units: false
is: HMDB00295
name: UDP
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
is: CHEBI:58223
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaM kynate c
is: SBO:0000247
name: kynurenate
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
constant: false
is: HMDB00715
is: CHEBI:58454
boundary condition: false
has only substance units: false

metaR SERGLYexR
modifier: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000304
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
name: L-Serine/Glycine reversible exchange
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR PHCHGSm
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_c289e8aa_c32f_413b_96ff_8e7ee84f9bd8
initial concentration: NaN
is: SBO:0000252
name: PI4KB
boundary condition: true
constant: false
is encoded by: hsa:5298
initial amount: NaN
has only substance units: false
is: Q9UBF8
type: Species

metaM so4 m
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: HMDB01448
is: SBO:0000247
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: CHEBI:16189
initial amount: NaN
name: sulfate

http://identifiers.org/biomodels.db/MODEL1310110021#_b297307d_65c6_4763_aa35_d6eed942ac95
name: VNN3:VNN2:VNN1
initial concentration: NaN
is encoded by: hsa:55350
boundary condition: true
is: SBO:0000297
type: Species
is encoded by: hsa:8875
constant: false
initial amount: NaN
has only substance units: false
has part: O95498

metaR r1546
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM onpthl e
notes: FORMULA: C10H8O CHARGE: 0 INCHI: InChI=1/C10H8O/c1-2-4-8-7(3-1)5-6-9-10(8)11-9/h1-6,9-10H
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB06215
name: naphthalene epoxide
boundary condition: false
constant: false
is: SBO:0000247

metaR HEXDIACTD
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_8f5101d8_5227_4f01_bfbe_eca47df0457c
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:8560
boundary condition: true
initial amount: NaN
constant: false
name: DEGS1
initial concentration: NaN
is: O15121

metaR C4CRNe
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR r0549
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.6.99.3
reactant: MODEL1310110021#
reversible: true
fast: false
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.6.5.3
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.1.1.17
product: MODEL1310110021#

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

metaR APOCF
type: Reaction
name: Apocarboxylase formation
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
product: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#

metaR RE0944E
type: Reaction
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
name: RE0944
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
reactant: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_f783f764_6c77_48a4_a60d_1bbb8598bf11
boundary condition: true
type: Species
name: ABP1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:26
is: P19801
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_519e15b5_bb49_478f_bf4a_424ac0ff72d5
name: TK2
boundary condition: true
constant: false
is: SBO:0000252
is: O00142
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:7084

metaM nadh x
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: C00004
constant: false
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
initial concentration: 1.0
is: HMDB01487
is: CHEBI:57945
initial amount: NaN

metaM Rtotalcoa c
is: CHEBI:16189
boundary condition: false
initial amount: NaN
name: R total Coenzyme A
has only substance units: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
initial concentration: 1.0
is: HMDB01448
type: Species
constant: false
is: SBO:0000247

metaR KYNAKGAT
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.6.1.7
modifier: MODEL1310110021#
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e040c326_d404_43ca_b183_924507e17935
has only substance units: false
type: Species
is: Q9BV79
initial concentration: NaN
name: MECR
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:51102

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_1509eaa0_1147_44e4_8cf3_710125b56bfd
name: ALDH9A1
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:223
is: P49189
constant: false
initial concentration: NaN
initial amount: NaN

metaR LEUt5m
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110021#
name: leucine mitochondrial transport
is: SBO:0000185
product: MODEL1310110021#

metaM aacoa c
constant: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: C00332
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Acetoacetyl-CoA
is: CHEBI:57286
is: HMDB01484
type: Species
has only substance units: false
boundary condition: false

metaM 13 cis retn r
name: 13-cis-retinoate
is: HMDB06219
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7847414
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
type: Species
is: D00348
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

metaR NDPK10n
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_9e18a770_457a_407e_860f_172103d87463
name: PLCG1
is: P19174
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5335
boundary condition: true
type: Species

metaM HC00591 c
name: 2-oxoglutaramate
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:16769
boundary condition: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

http://identifiers.org/biomodels.db/MODEL1310110021#_8aacc9b6_aacb_45cb_86b4_00b272ca94f4
type: Species
name: ADH1B:ADH1C
is encoded by: hsa:126
constant: false
has part: P00326
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d204ba03_a924_4fed_94ab_740d8c8f78a6
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:6389
is: SBO:0000252
is: P31040
name: SDHA
initial amount: NaN
type: Species

metaM 4hexdtricoa m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 4,7,10-hexadecatrienoylcoa
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
type: Species

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaM CE2421 m
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: CHEBI:30623
constant: false
name: (3S)-3-hydroxylinoleoyl-CoA
is: SBO:0000247
is: HMDB02329
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1747907e_df7f_4f9e_b5a6_8b08e6bafa2e
type: Species
boundary condition: true
is encoded by: hsa:56606
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: SLC2A9
is: Q9NRM0
is: SBO:0000252

metaM zymst r
is: SBO:0000247
initial amount: NaN
is: HMDB06271
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: CHEBI:18252
name: zymosterol

http://identifiers.org/biomodels.db/MODEL1310110021#_98a5d3f9_a0eb_4cdc_887c_f34afefc05d2
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: _22305_1_c
initial concentration: NaN
is encoded by: hsa:22305
initial amount: NaN
boundary condition: true

metaR TRDR
reversible: false
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.9
kinetic law: MODEL1310110021#
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
product: MODEL1310110021#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110021#_2a1353dd_43f1_435c_8987_e7d0cd2a2db0
constant: false
is encoded by: hsa:4717
initial amount: NaN
has only substance units: false
type: Species
is: O43677
boundary condition: true
name: NDUFC1
initial concentration: NaN
is: SBO:0000252

metaR r0276
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
product: MODEL1310110021#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_f53346f8_6eac_48af_a40c_6daa39a0c5a3
has only substance units: false
name: _U52111_1_c
type: Species
initial concentration: NaN
is encoded by: hsa:U52111
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_69aaff22_a756_48b3_888b_402062944ff2
is encoded by: hsa:197257
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: LDHD
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_b6d33a8b_76dc_4177_b4ff_f055b306b689
has only substance units: false
is encoded by: hsa:C7orf24
name: _C7orf24_1_m
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaM HC02217 e
initial concentration: 1.0
boundary condition: false
name: prostaglandin-g2
type: Species
has only substance units: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
constant: false
initial amount: NaN
is: SBO:0000247

metaR r1177
name: EC:3.1.1.13
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_e006ed4a_8192_4cfc_b2f7_12cc7b65d7f3
has only substance units: false
boundary condition: true
is: P31350
initial concentration: NaN
name: RRM2
is: SBO:0000252
is encoded by: hsa:6241
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_6434139c_e77d_4bb1_8221_cf7885598c8c
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:10396
is: SBO:0000252
constant: false
is: Q9Y2Q0
has only substance units: false
name: ATP8A1

metaM ocdcea l
type: Species
name: oleate
is: HMDB00207
is: SBO:0000247
is: CHEBI:30823
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
has only substance units: false
initial concentration: 1.0

metaR CYTK1
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
name: cytidylate kinase (CMP)
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
fast: false
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_28d9dd90_7123_4ed1_8cb0_34cd8445eda6
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM sphings c
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
has only substance units: false
type: Species
is: CHEBI:57756
initial concentration: 1.0
is: HMDB00252
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
name: sphingosine(1+)

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaR DM atp c
is: SBO:0000176
kinetic law: MODEL1310110021#
name: DM_atp(c)
fast: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_e39cd6a2_88b2_4e6d_ab68_8a3abc197145
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: GCDH
is encoded by: hsa:2639
constant: false
is: Q92947
has only substance units: false

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaR HACD9m
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
fast: false
is: SBO:0000176
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM pan4p m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
has only substance units: false
is: CHEBI:47942
is: HMDB01416
constant: false
name: pantetheine 4'-phosphate(2-)
is: SBO:0000247
type: Species
boundary condition: false

metaR r1544
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185

metaM cdpdag hs c
is: CHEBI:58332
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
name: CDP-diacylglycerol(2-)
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_4b30f09f_086c_4c13_88a8_489a509e3bc3
name: AADAT
constant: false
type: Species
is encoded by: hsa:51166
has only substance units: false
initial amount: NaN
is: Q8N5Z0
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR LPCOXp
type: Reaction
kinetic law: MODEL1310110021#
name: L-pipecolate oxidase, peroxisomal
reversible: false
is: SBO:0000176
product: MODEL1310110021#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
is version of: http://identifiers.org/ec-code/1.5.3.1

http://identifiers.org/biomodels.db/MODEL1310110021#_ba5425a1_659c_4ee0_851c_2f18b0536058
is encoded by: hsa:3707
is: P27987
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: ITPKB
has only substance units: false

metaR EHGLAT2m
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
reactant: MODEL1310110021#
reversible: false
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
fast: false
modifier: MODEL1310110021#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.6.1.1

metaR r1010
fast: false
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_20158301_f3cb_428f_923d_0dc04c7425ba
constant: false
name: NDUFS7
is: O75251
has only substance units: false
is encoded by: hsa:374291
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

metaM pnto R c
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00210
name: (R)-Pantothenate
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_54e4b6d2_3cad_42fb_80e7_11dd9c5c9a41
boundary condition: true
constant: false
is: Q99798
has only substance units: false
initial amount: NaN
is encoded by: hsa:50
name: ACO2
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_3fed61d2_3eae_4e19_aa35_c78d9b7d2f86
is: SBO:0000252
initial concentration: NaN
name: NDUFA3
initial amount: NaN
is: O95167
constant: false
is encoded by: hsa:4696
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_8a5b79fc_b888_4998_92ca_f1b93c92ef8b
initial amount: NaN
name: _AI378339_1_m
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:AI378339

metaM xol25oh r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06247
has only substance units: false
initial amount: NaN
is: CHEBI:42977
boundary condition: false
name: 25-hydroxycholesterol
type: Species

metaM HC02175 e
initial amount: NaN
name: caprate
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
has only substance units: false
is: CHEBI:27689
type: Species

metaR CHAT
modifier: MODEL1310110021#
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
fast: false
is: SBO:0000176
name: Choline O-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
reactant: MODEL1310110021#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110021#_565b5fa4_806d_449c_8b2f_1e54ba508a52
type: Species
boundary condition: true
has only substance units: false
name: PRDX1
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5052
is: Q06830
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_1d1cfa9d_3825_438d_9bb9_1eca5f88fd51
name: _AI924226_1_m
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:AI924226
has only substance units: false
initial amount: NaN
boundary condition: true

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaR ASCBOX
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
reversible: false
name: ascorbic acid oxidase
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110021#
fast: false

metaR r2139
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110021#
fast: false
type: Reaction
kinetic law: MODEL1310110021#
reversible: true

metaR DNDPt22m
type: Reaction
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110021#
product: MODEL1310110021#
name: dTDP transport via dUDP antiport
reactant: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_2e4f708a_3478_4d18_85af_87aa3e6acdc0
is: A0PJJ9
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2686
is: SBO:0000252
has only substance units: false
name: GGT7
initial amount: NaN
type: Species
constant: false

metaR q10tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000134
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000185
name: transport of ubiquinone into mitochondria
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_5eb6fe05_4920_40a7_936d_979e7c6bc481
initial amount: NaN
is encoded by: hsa:3284
name: HSD3B2
is: P26439
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR LEUKTRB4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene B4 transport
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110021#

metaR PETOHMr hs
modifier: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
type: Reaction
name: phosphatidylethanolamine N-methyltransferase
is described by: ECO:0000254
product: MODEL1310110021#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17

metaR SPHS1Ptr
type: Reaction
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
name: sphingosine-1-phosphate transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_4010516a_d32c_409a_9803_b273f934d72d
boundary condition: true
name: ALDH1A3
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P47895
constant: false
is encoded by: hsa:220
initial concentration: NaN

metaR MCLACCYSR
type: Reaction
name: 3-mercaptolactate:cysteine reductase
kinetic law: MODEL1310110021#
fast: false
reversible: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110021#

metaM dcyt e
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: HMDB00014
constant: false
initial concentration: 1.0
name: Deoxycytidine
type: Species
initial amount: NaN
is: CHEBI:15698
has only substance units: false
boundary condition: false
is: C00881
is: SBO:0000247

metaR APOC LYS BTNPm
name: proteolysis of apoC-Lys-btn, mitochondrial
product: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110021#
is: SBO:0000176
reversible: false
reactant: MODEL1310110021#

metaM dectricoa m
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
name: 2,4,7-decatrienoylcoa
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C31H44N7O17P3S CHARGE: -4

metaM so4 l
constant: false
is: SBO:0000247
name: sulfate
boundary condition: false
has only substance units: false
is: CHEBI:16189
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448

http://identifiers.org/biomodels.db/MODEL1310110021#_7f5fa75b_efe6_4551_b229_7773b4378db8
type: Species
boundary condition: true
initial concentration: NaN
is: Q6PCB7
constant: false
has only substance units: false
is encoded by: hsa:376497
is: SBO:0000252
initial amount: NaN
name: SLC27A1

metaR r2136
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185

metaM udp g
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
boundary condition: false
is: SBO:0000247
is: CHEBI:58223
has only substance units: false
is: HMDB00295
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_04e6964d_8a1a_4594_b3a6_8cbaff19b795
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: O00754
is: SBO:0000252
name: MAN2B1
boundary condition: true
is encoded by: hsa:4125
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_ba2eb368_dbd5_4a9a_9249_f73339f202e0
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:50484
is: Q7LG56
has only substance units: false
type: Species
boundary condition: true
name: RRM2B

http://identifiers.org/biomodels.db/MODEL1310110021#_e868958f_c5b2_4621_b244_65ea7bdb77d1
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6532
is: SBO:0000252
boundary condition: true
is: P31645
constant: false
type: Species
name: SLC6A4

http://identifiers.org/biomodels.db/MODEL1310110021#_6058c6b2_c1dd_4168_b9d0_486d64fe4538
name: SLC2A8
initial amount: NaN
constant: false
is: Q9NY64
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:29988
initial concentration: NaN

metaR ORNt3m
is: SBO:0000185
modifier: MODEL1310110021#
product: MODEL1310110021#
fast: false
type: Reaction
reactant: MODEL1310110021#
name: ornithine mitochondrial transport via proton antiport
kinetic law: MODEL1310110021#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_0343cf93_377c_4a4e_87c1_83731f629749
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:11001
is: O14975
is: SBO:0000252
name: SLC27A2
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_8ca84bbb_aa9c_421e_900c_1ea51cfa54fe
name: NDUFB4
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:4710
is: O95168
has only substance units: false

metaM dpcoa m
has only substance units: false
is: HMDB01373
constant: false
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_b5b993a3_e51e_49a7_b007_eaaf229ba455
is encoded by: hsa:6307
has only substance units: false
type: Species
is: A8MYF6
boundary condition: true
initial concentration: NaN
name: MSMO1
is: SBO:0000252
constant: false
initial amount: NaN

metaR r0170
kinetic law: MODEL1310110021#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reactant: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
product: MODEL1310110021#
fast: false
reversible: true
is: SBO:0000176

metaM pnto R e
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00210
boundary condition: false
initial amount: NaN
name: (R)-Pantothenate
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568

http://identifiers.org/biomodels.db/MODEL1310110021#_8f99ec33_7536_4aa9_9178_453af1c603b6
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:1808
type: Species
is: B4DR31
name: DPYSL2
has only substance units: false

metaM 56dthm c
name: 5,6-dihydrothymine
is: CHEBI:27468
is: HMDB00079
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
has only substance units: false

metaR r0384
product: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
kinetic law: MODEL1310110021#
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_202c6e4b_3692_4fa3_a8ff_ac9022c5ee5d
is: Q6PII5
boundary condition: true
constant: false
initial concentration: NaN
name: HAGHL
is encoded by: hsa:84264
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_3f176c02_f405_47de_b73a_d8e9914b4f87
boundary condition: true
is encoded by: hsa:29920
initial amount: NaN
type: Species
is: Q96C36
is: SBO:0000252
name: PYCR2
has only substance units: false
constant: false
initial concentration: NaN

metaR r1435
name: Transport reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reversible: false
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaM HC01408 m
initial amount: NaN
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
has only substance units: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:27648
name: 3-Oxohexanoyl-CoA
boundary condition: false
initial concentration: 1.0

metaR r2137
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110021#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.14.6

http://identifiers.org/biomodels.db/MODEL1310110021#_6cc29cf3_8fe3_471f_b03a_9565f701a1f1
type: Species
initial amount: NaN
name: ACAA2
initial concentration: NaN
boundary condition: true
has only substance units: false
is: P42765
is encoded by: hsa:10449
constant: false
is: SBO:0000252

metaR DHFtl
is: SBO:0000185
product: MODEL1310110021#
reversible: true
is described by: ECO:0000000
name: dihydrofolate reversible lysosomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
fast: false

metaR r0480
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reversible: true
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176

metaM nadh m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57945
is: C00004
constant: false
is: http://identifiers.org/pubchem.compound/3306
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN
boundary condition: false
is: HMDB01487
type: Species

metaM ametam c
initial concentration: 1.0
type: Species
is: CHEBI:57443
name: S-Adenosylmethioninamine
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: C01137
is: HMDB00988
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_39a0d25a_c95e_455c_b1a2_a37fea86e18a
name: SLC38A2
constant: false
type: Species
is: Q96QD8
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:54407

metaM udp e
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: HMDB00295
constant: false
name: UDP(3-)
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58223
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_02f6701f_6aa9_471d_a750_34092da746f7
has only substance units: false
is: E9PHN8
name: HEPH
initial amount: NaN
is encoded by: hsa:9843
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR DUMPtn
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110021#
reversible: true

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247
boundary condition: false
name: prostaglandin-c2
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:27555
initial amount: NaN
constant: false

metaM dmnoncrn x
initial concentration: 1.0
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: HMDB06202
is: SBO:0000247
name: 4,8-dimethylnonanoyl carnitine

metaM 4ppcys m
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial concentration: 1.0
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:59458
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d2564664_f95a_467a_8dbf_56c4e6ec2ad2
is: SBO:0000252
type: Species
is: Q16881
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:7296
has only substance units: false
initial concentration: NaN
name: TXNRD1

http://identifiers.org/biomodels.db/MODEL1310110021#_3e02c8e9_032d_427f_ad79_e541afcbc19e
type: Species
is: SBO:0000252
initial concentration: NaN
is: E7EQF2
boundary condition: true
is encoded by: hsa:54677
has only substance units: false
constant: false
initial amount: NaN
name: CROT

metaM 56dura c
type: Species
name: 5,6-dihydrouracil
has only substance units: false
is: CHEBI:15901
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: HMDB00076

metaR r1919
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_92c03453_038d_4738_b969_94337762e2d4
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:8803
has only substance units: false
name: SUCLA2
initial concentration: NaN
is: E5KS60
constant: false

metaR AKR1D
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is version of: http://identifiers.org/ec-code/1.3.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110021#
reversible: false
modifier: MODEL1310110021#

metaR r0385
product: MODEL1310110021#
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
reversible: false
type: Reaction

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_e2ead4f3_ce7c_4d28_8ce2_cd40c078abda
type: Species
constant: false
name: NME1
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:4830

metaR r0309
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110021#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.22

metaM bilglcur r
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:57767
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false
initial concentration: 1.0

metaM utp n
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:46398
type: Species
has only substance units: false
name: UTP(4-)

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaM dhcholestanate c
type: Species
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:16577
constant: false
initial concentration: 1.0

metaM aacoa m
is: CHEBI:57286
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
name: acetoacetyl-CoA(4-)
initial concentration: 1.0

metaR CHSTEROLtrc
type: Reaction
is described by: ECO:0000134
fast: false
reversible: true
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: transport of cholesterol into the cytosol
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_5ac65b44_4fc7_48c1_903d_2ad0972a7f20
constant: false
initial concentration: NaN
name: CAT
is: SBO:0000252
boundary condition: true
is: P04040
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:847

metaR NDP7g
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
name: nucleoside-diphosphatase (UDP), Golgi apparatus
modifier: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#

metaM pail3p hs c
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
boundary condition: false
is: CHEBI:58088
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_5f6678bf_47fe_4da9_bd12_5027b716dc23
is: Q9BV79
initial amount: NaN
is: SBO:0000252
type: Species
name: MECR
is encoded by: hsa:51102
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_6a19e534_2e65_4fa7_b002_5041ca63f3dc
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: FOLR1
initial amount: NaN
constant: false
is encoded by: hsa:2348

metaR SUCD1m
name: succinate dehydrogenase
is described by: ECO:0000134
reversible: true
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.5.1
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
modifier: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
type: Reaction

metaM ala B c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: HMDB00056
is: CHEBI:16958

metaR P4502D6
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.14.14.1
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
name: cytochrome P450 2D6
notes: GENE_ASSOCIATION: (1565.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES:debrisoquine 4-hydroxylation assumed to take place on outer membrane NJ
type: Reaction

metaM C05279 m
is: HMDB11123
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: CHEBI:28387
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: trans,cis-Lauro-2,6-dienoyl-CoA

metaR PPNCL3
is version of: http://identifiers.org/ec-code/6.3.2.5
modifier: MODEL1310110021#
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110021#
is described by: ECO:0000269
name: phosphopantothenate-cysteine ligase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_391c7d82_7a71_4b29_89c1_4f2e201cd8be
initial concentration: NaN
is: SBO:0000252
name: NDUFB9
is: Q9Y6M9
initial amount: NaN
is encoded by: hsa:4715
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM so4 e
type: Species
is: CHEBI:16189
is: HMDB01448
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
has only substance units: false
boundary condition: false

metaR r0308
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e52d1d9d_ca27_45b9_af9e_fbce6d569733
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55512
type: Species
is: A8K0T6
name: SMPD3
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

metaM ocdcea e
is: HMDB00207
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
type: Species
is: CHEBI:0
name: octadecenoate (n-C18:1)
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: C00712

http://identifiers.org/biomodels.db/MODEL1310110021#_6c27e109_a426_4d72_8dfb_e667dbc178c3
initial concentration: NaN
initial amount: NaN
name: ELOVL5
type: Species
is: F6SH78
constant: false
is encoded by: hsa:60481
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_2c8655ec_284f_4b6a_9a2b_55cdfd7170dc
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P19404
name: NDUFV2
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:4729

metaR r1659
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000

metaM hmgcoa x
constant: false
type: Species
is: CHEBI:15467
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
is: HMDB01375
has only substance units: false
name: Hydroxymethylglutaryl-CoA
initial concentration: 1.0
is: SBO:0000247

metaR r1433
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000000

metaM 1pyr5c m
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 1-Pyrroline-5-carboxylate
has only substance units: false
boundary condition: false
is: C03912
is: HMDB01301
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: CHEBI:15893

metaR BACCL
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110021#
type: Reaction
is: SBO:0000176
name: biotin-[acetyl-CoA-carboxylase] ligase
reversible: false
product: MODEL1310110021#
reactant: MODEL1310110021#

MODEL1310110021#
species: metaM for r
species: metaM damp c
species: metaM ach n
species: metaM arachdcoa x
species: metaM ala D e
species: metaM ser D c
species: metaM for e
species: metaM dttp n
species: metaM HC02203 e
species: metaM ac c
species: metaM 5fthf m
species: metaM hxan e
species: metaM C02528 r
species: metaM lac L e
species: metaM udp e
species: metaM CE4790 m
species: metaM frdp r
species: metaM bilirub r
species: metaM gum e
species: metaM sphs1p c
species: metaM grdp x
species: metaM 3mop m
species: metaM dudp m
species: metaM fe2 c
species: metaM dgmp e
stoichiometry: 0.009898
species: metaM 10fthf5glu e
species: metaM o2s m
species: metaM hco3 m
species: metaM acac e
species: metaM crn c
species: metaM pristanal c
species: metaM mmcoa S m
species: metaM glyc R c
species: metaM cholate c
species: metaM lnlncg c
species: metaM HC02214 c
species: metaM gtp m
species: metaM acnacngalgbside hs g
species: metaM ocdcea r
species: metaM oxa m
species: metaM hdcea r
species: metaM pe hs c
species: metaM hx2coa m
species: metaM coa n
species: metaM nad r
species: metaM dmnoncrn m
species: metaM vitd3 e
species: metaM g6p r
species: metaM aacoa x
species: metaM HC02210 c
species: metaM 3dodtricoa m
species: metaM hpyr c
species: metaM dcsptn1 e
species: metaM CE5236 c
species: metaM na1 e
species: metaM ala D c
species: metaM cspg c e
species: metaM prist c
species: metaM pristcoa x
species: metaM trdrd m
species: metaM h2o c
species: metaM but e
species: metaM thbpt4acam n
species: metaM fadh2 r
species: metaM lac L c
species: metaM omhpal r
stoichiometry: 0.020401
stoichiometry: 1.96
species: metaM cmp g
species: metaM dcholcoa x
species: metaM pail5p hs c
type: SBMLUnitsDef
species: metaM dlnlcgcoa r
species: metaM CE2839 e
stoichiometry: 0.279425
species: metaM nrvnc e
species: metaM octa c
species: metaM thmmp c
species: metaM pyr m

http://identifiers.org/biomodels.db/MODEL1310110021#_06e40622_4f80_46fb_a286_ae8683191f67
initial concentration: NaN
is encoded by: hsa:8527
name: DGKD
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM formcoa c
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
boundary condition: false
name: formyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB03419
is: CHEBI:57376
type: Species
constant: false

metaR ACCOALm
type: Reaction
modifier: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
is: SBO:0000176
fast: false
name: acetate-CoA ligase (AMP-forming)
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000304
product: MODEL1310110021#

metaR LNSTLSr
reversible: false
modifier: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
reactant: MODEL1310110021#
name: lanosterol synthase
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.4.99.7
is: SBO:0000176
type: Reaction

metaM 3dsphgn c
initial concentration: 1.0
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
is: CHEBI:58299
is: HMDB01480
has only substance units: false
boundary condition: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
constant: false
initial amount: NaN
is: SBO:0000247

metaR r0990
fast: false
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaR MI3PP
kinetic law: MODEL1310110021#
name: myo-inositol 3-phosphatase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110021#
is: SBO:0000176
reversible: false
product: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25

metaM HC02207 c
has only substance units: false
initial amount: NaN
is: CHEBI:27555
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
name: prostaglandin-c2
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR CLOXAtex2
reversible: false
is described by: ECO:0000304
product: MODEL1310110021#
name: chloride transport via oxalate countertransport (2:1)
is: SBO:0000185
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
fast: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction

metaM 10fthf7glu e
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial concentration: 1.0
is: SBO:0000247
is: HMDB00972
has only substance units: false
boundary condition: false
type: Species
constant: false
initial amount: NaN
name: 10-formyltetrahydrofolate-[Glu](7)
is: CHEBI:57454

metaR 3HCO3 NAt
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000134
fast: false
name: 3HCO3_NAt
product: MODEL1310110021#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
kinetic law: MODEL1310110021#

metaR FAOXC2251836m
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
product: MODEL1310110021#
fast: false
reversible: false
name: Beta oxidation of fatty acid
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110021#

metaR KYNATESYN
product: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
fast: false
type: Reaction
is: SBO:0000176
reversible: false

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR r0483
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110021#
reversible: true
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22

http://identifiers.org/biomodels.db/MODEL1310110021#_47cd66b3_bc05_433f_aa7e_99f460324280
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:116369
name: SLC26A8
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR RE2998M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110021#
type: Reaction
reversible: false
name: RE2998
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#

metaR r1658
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
type: Reaction
fast: false
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_d8305b94_1216_4e0a_a55e_b2f07f5f37fc
constant: false
initial concentration: NaN
name: SLC27A2
initial amount: NaN
is: O14975
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11001
type: Species
has only substance units: false

metaM gcald c
name: glycolaldehyde
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: HMDB03344
initial amount: NaN
is: CHEBI:17071
initial concentration: 1.0
type: Species
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266

metaM 4aphdob c
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58147
type: Species
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
boundary condition: false
is: HMDB00978
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252

metaR RE0827E
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.3.22
name: RE0827
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110021#

metaM HC02175 c
name: caprate
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
has only substance units: false
constant: false
is: CHEBI:27689

metaR UDPGLCAter
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110021#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
reactant: MODEL1310110021#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
product: MODEL1310110021#

metaM retinal 11 cis c
is: CHEBI:16066
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
name: 11-cis-retinal
is: HMDB02152
initial concentration: 1.0

metaM pacald c
initial amount: NaN
has only substance units: false
is: CHEBI:16424
initial concentration: 1.0
is: HMDB06236
constant: false
name: phenylacetaldehyde
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
type: Species

metaM ala B e
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false
initial amount: NaN
constant: false
name: beta-alanine
boundary condition: false
type: Species
is: HMDB00056
is: CHEBI:16958
is: SBO:0000247

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM gar c
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: CHEBI:58457
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB02022
is: C03838
initial amount: NaN
name: N1-(5-Phospho-D-ribosyl)glycinamide
has only substance units: false

metaR SO4HCOtex
is described by: ECO:0000304
reversible: false
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
name: sulfate transport via bicarbonate countertransport
fast: false
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#

metaM ocdcea c
is: C00712
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:0
constant: false
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
has only substance units: false
name: octadecenoate (n-C18:1)

http://identifiers.org/biomodels.db/MODEL1310110021#_20c0bb93_dbff_4a65_9437_bce395a0e9da
boundary condition: true
initial concentration: NaN
constant: false
is: O43570
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:771
name: CA12
initial amount: NaN

metaR FAS160COA
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
name: fatty-acyl-CoA synthase (n-C16:0CoA)

metaR ARABR
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.21
product: MODEL1310110021#
fast: false
name: arabinose reductase
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
modifier: MODEL1310110021#
reversible: false

metaR r1657
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110021#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#

metaR r1431
fast: false
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
product: MODEL1310110021#
reversible: false
is described by: ECO:0000000

metaR PPCDC
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.1.1.36
fast: false
kinetic law: MODEL1310110021#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110021#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:
name: phosphopantothenoylcysteine decarboxylase

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_3f788ebe_cd42_41d7_a411_37f97c594a6b
name: GPX5
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is: O75715
has only substance units: false
boundary condition: true
is encoded by: hsa:2880
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_c7b45220_6e28_4b15_a40e_d56b478a16a9
is: Q9Y345
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: SLC6A5
is encoded by: hsa:9152
has only substance units: false
type: Species

metaR RE0915E
kinetic law: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
product: MODEL1310110021#
reversible: true
name: RE0915
is described by: ECO:0000000
reactant: MODEL1310110021#

metaR r0839
name: Postulated transport reaction
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.70
is described by: ECO:0000000
reactant: MODEL1310110021#
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
fast: false
product: MODEL1310110021#

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_7b41f6a9_0968_4d5f_abfb_8c842fb3540c
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: Q8NFF5
is encoded by: hsa:80308
initial concentration: NaN
name: FLAD1
initial amount: NaN

metaR ASCBt
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
is: SBO:0000185
name: L-ascorbate transport via facilitated diffusion
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000

metaM urate e
is: SBO:0000247
type: Species
is: CHEBI:17775
name: Urate
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00289
initial concentration: 1.0
boundary condition: false

metaR RE2625C
reversible: true
is: SBO:0000176
name: RE2625
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false

metaR r2320
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaM bhb c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:10983
is: HMDB00011
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate

metaR r0165
type: Reaction
modifier: MODEL1310110021#
fast: false
name: UTP:pyruvate O2-phosphotransferase EC:2.7.1.40
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaM ac m
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
is: CHEBI:30089
initial amount: NaN
is: HMDB00042
name: acetate
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

metaR r0994
name: Facilitated diffusion
is described by: ECO:0000000
type: Reaction
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true

metaM pail45p hs m
has only substance units: false
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate

metaR r1655
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_06188d44_6b40_4406_a996_2340d5d5d520
constant: false
name: INPP5J
boundary condition: true
is encoded by: hsa:27124
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
is: Q15735
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_09785ee2_2658_49f1_9bf7_72e40bc07bfa
is: Q13615
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8897
name: MTMR3
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_c3164137_f426_408f_a684_0c82e9f88b31
type: Species
is: Q9HBH5
has only substance units: false
is encoded by: hsa:57665
is: SBO:0000252
initial concentration: NaN
name: RDH14
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_c9f10cbd_b501_46c0_bf3d_12b1396a6203
initial concentration: NaN
name: CA5B
boundary condition: true
constant: false
has only substance units: false
is: Q9Y2D0
is: SBO:0000252
is encoded by: hsa:11238
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_0d9620b9_cb03_4ee6_98dd_a87b63255623
type: Species
initial concentration: NaN
boundary condition: true
name: UPP2
has only substance units: false
is encoded by: hsa:151531
is: SBO:0000252
constant: false
is: O95045
initial amount: NaN

metaM succ c
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
is: C00042
is: CHEBI:30031
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
initial amount: NaN
initial concentration: 1.0

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM dhcholestanate x
is: CHEBI:16577
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial concentration: 1.0
is: HMDB00359
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR RE0453N
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
modifier: MODEL1310110021#
is described by: ECO:0000000
fast: false
name: RE0453
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_a94c576e_9abc_4a73_9e51_6d806e4fcaf2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9NYW8
type: Species
is encoded by: hsa:57786
constant: false
boundary condition: true
name: RBAK
initial concentration: NaN

metaR r2142
reactant: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_5bd657b8_1291_435a_b424_24059e2abad8
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:226
has only substance units: false
name: ALDOA

metaR r2321
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110021#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_db794489_6337_4852_9aca_c94a598061ed
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9NVE7
is encoded by: hsa:55229
initial amount: NaN
type: Species
boundary condition: true
constant: false
name: PANK4

metaR DM fol
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaM HC00591 m
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
constant: false
is: CHEBI:16769
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_372657ae_cc6c_477e_bcd4_995245e3df3d
has only substance units: false
is: A8K3J4
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: CA14
type: Species
is encoded by: hsa:23632

metaM pristcoa x
type: Species
name: pristanoyl coa
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial concentration: 1.0
is: CHEBI:51341
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaR GGLUCT
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
is: SBO:0000185
fast: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.2.4
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000269
reversible: false
name: gamma-glutamylcyclotransferase

metaR HAtly
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110021#
reversible: false
name: hyaluronan transport, extracellular to lysosome
kinetic law: MODEL1310110021#
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_fab45cd6_aef9_44f3_a548_00f0a0f0e0a1
name: ALDH7A1
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:501
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: E7EPT3

metaR BTND1
modifier: MODEL1310110021#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.1.12
name: biotinidase (biotin)
is described by: ECO:0000269
product: MODEL1310110021#
reversible: false

metaM HC01115 c
is: SBO:0000247
constant: false
name: NeuNGc
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:29025
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
type: Species

metaM dhdascb e
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial amount: NaN
type: Species
is: HMDB01264
constant: false
is: CHEBI:58070
initial concentration: 1.0
boundary condition: false
name: dehydroascorbide(1-)
has only substance units: false
is: SBO:0000247

metaM pail45p hs n
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247
type: Species
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1b5d7829_0da4_47d8_9a67_399d551487c3
is: O00624
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:10246
initial concentration: NaN
name: SLC17A2
initial amount: NaN
is: SBO:0000252

metaR r1656
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: MODEL1310110021#
fast: false

metaR VITD3t2
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
name: Vitamin D3 uptake
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_1381d2f8_8d70_4859_aae2_8e1efcbff26e
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: HAGHL
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84264

metaR PHEACGLNt
product: MODEL1310110021#
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
reactant: MODEL1310110021#
is described by: ECO:0000000
name: PHEACGLN extracellular transport via diffusion
kinetic law: MODEL1310110021#
is: SBO:0000185

metaR RE1796M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
reversible: true
name: RE1796
fast: false
reactant: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#

metaR CHOLtu
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
name: Choline uniport
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
product: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_76787d13_6c0f_4ec6_af49_c9207a0b10dd
initial amount: NaN
has only substance units: false
is encoded by: hsa:6309
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q6GTM5
name: SC5DL
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_4846fb9b_a723_4b5b_aaf3_9c557e781dd5
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AA278423_1_m
type: Species
has only substance units: false
is encoded by: hsa:AA278423
constant: false
boundary condition: true

metaM oagd3 hs c
is: C00029
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
name: 9-O-Acetylated GD3
is: CHEBI:58367
is: HMDB00286

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_b8a304b8_c4c6_4cd8_ba60_0b817d19d944
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR r2141
modifier: MODEL1310110021#
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110021#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaM urate c
is: SBO:0000247
name: Urate
type: Species
is: CHEBI:17775
has only substance units: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial concentration: 1.0
boundary condition: false
is: C00366
initial amount: NaN
constant: false
is: HMDB00289

metaM mi3p D c
is: SBO:0000247
is: HMDB06814
name: 1D-myo-inositol 3-phosphate(2-)
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1
is: CHEBI:58401
has only substance units: false
boundary condition: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaM pe hs e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
constant: false
type: Species
is: CHEBI:16038
initial concentration: 1.0
name: phosphatidylethanolamine
boundary condition: false
initial amount: NaN

metaR XYLTD Dr
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000176
reversible: true
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
name: xylitol dehydrogenase (D-xyulose-forming)

http://identifiers.org/biomodels.db/MODEL1310110021#_8681c7dc_bd63_4904_9ff3_9310421c7390
has only substance units: false
name: SLC6A9
constant: false
initial concentration: NaN
is: P48067
is encoded by: hsa:6536
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaR r1653
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000185
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaM prostge1 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
name: prostaglandin E1(1-)
is: CHEBI:57397
is: HMDB01442
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_13054a7c_68d9_40b5_9859_1a5224c77687
constant: false
is: O95573
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2181
name: ACSL3

http://identifiers.org/biomodels.db/MODEL1310110021#_4e4ff25f_9131_44d0_b946_eb9b22821939
is: SBO:0000252
is encoded by: hsa:5169
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: Q308M7
name: ENPP3

metaR BACCLm
fast: false
is: SBO:0000176
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000254
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_f795d485_58da_41f0_b507_05a332becabb
name: NDUFS5
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4725
constant: false
is: Q6IBA0

metaM so4 c
name: sulfate
is: HMDB01448
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:16189
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false

metaR GLUDym
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
product: MODEL1310110021#
is described by: ECO:0000269
fast: false
name: glutamate dehydrogenase (NADP), mitochondrial
type: Reaction
reversible: true
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#

metaR r1116
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185
reactant: MODEL1310110021#
product: MODEL1310110021#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
reversible: true
is described by: ECO:0000000
fast: false

metaR FBA
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
fast: false
is described by: ECO:0000134
name: fructose-bisphosphate aldolase
reversible: true
type: Reaction
is: SBO:0000176

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_9432d8af_9973_4fd4_8979_0b48114d21d3
initial amount: NaN
has only substance units: false
name: OXSM
is: Q9NWU1
initial concentration: NaN
is encoded by: hsa:54995
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaM HC01444 e
initial concentration: 1.0
type: Species
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
constant: false
name: Galactosylglycerol
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15754

metaR r2140
reactant: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110021#

metaR NDPK7n
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110021#
is described by: ECO:0000304
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
reactant: MODEL1310110021#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is: SBO:0000176
modifier: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_0aa18d92_8537_44bf_aae7_b9cc63c50f56
has only substance units: false
is encoded by: hsa:117247
type: Species
is: SBO:0000252
constant: false
is: Q8TF71
name: SLC16A10
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR CYTK8n
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110021#
name: cytidylate kinase (CMP,dATP),nuclear
is: SBO:0000176
fast: false
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_ab43d7dc_f1b3_49f1_adc6_8242c966ce89
name: ACOT6
is encoded by: hsa:641372
constant: false
initial concentration: NaN
is: Q3I5F7
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false

metaR PEROXx
fast: false
is described by: ECO:0000000
modifier: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
reversible: false
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
name: peroxisomal lumped long chain fatty acid oxidation
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR DHCR72r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
product: MODEL1310110021#
name: 7-dehydrocholesterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.21
kinetic law: MODEL1310110021#
reversible: false
is: SBO:0000176

metaM dha e
initial amount: NaN
is: HMDB01882
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
name: glycerone
is: CHEBI:16016
boundary condition: false

metaM 13dpg c
is: C00236
constant: false
initial amount: NaN
is: HMDB01270
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 3-Phospho-D-glyceroyl phosphate
is: CHEBI:57604
is: http://identifiers.org/pubchem.compound/3535
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_54de2949_8649_4b2b_a7de_a859ff626a9b
initial concentration: NaN
is encoded by: hsa:7371
is: SBO:0000252
has only substance units: false
name: UCK2
boundary condition: true
is: Q9BZX2
initial amount: NaN
constant: false
type: Species

metaM glyc R m
constant: false
type: Species
is: CHEBI:16659
is: HMDB00139
name: D-glycerate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

metaR r1654
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110021#
modifier: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true

metaR FPGS5m
kinetic law: MODEL1310110021#
type: Reaction
reversible: false
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
is described by: ECO:0000000
is: SBO:0000176
name: folylpolyglutamate synthetase (DHF), mitochondrial
is version of: http://identifiers.org/ec-code/6.3.2.17
modifier: MODEL1310110021#

metaM mi14p c
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
boundary condition: false
is: CHEBI:58282
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: HMDB00968
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

metaM dhdascb c
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01264
constant: false
initial concentration: 1.0
is: CHEBI:58070
boundary condition: false
name: dehydroascorbide(1-)
has only substance units: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425

metaM oagd3 hs e
constant: false
initial amount: NaN
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: CHEBI:18421
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB02168
boundary condition: false
name: 9-O-Acetylated GD3

metaR r1117
product: MODEL1310110021#
fast: false
name: Facilitated diffusion
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_c78f9b65_5488_4727_a94d_c92d9893c3b2
type: Species
name: CROT
initial amount: NaN
boundary condition: true
is: E7EQF2
is encoded by: hsa:54677
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR r0998
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110021#
name: Facilitated diffusion
reactant: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_4f9b52c9_cc58_431d_bdd2_ea112c20fea6
is: P11169
constant: false
initial amount: NaN
name: SLC2A3
has only substance units: false
type: Species
is encoded by: hsa:6515
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r1651
modifier: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false
reversible: true
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110021#
type: Reaction

metaM pe hs c
initial concentration: 1.0
boundary condition: false
is: CHEBI:16038
constant: false
name: phosphatidylethanolamine
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_22be194c_2625_47e2_9ff9_0ae73dde3229
is: SBO:0000252
initial concentration: NaN
constant: false
name: ACSL5
is encoded by: hsa:51703
boundary condition: true
type: Species
initial amount: NaN
is: Q9ULC5
has only substance units: false

metaR r2079
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_f4078b95_a926_4a69_8376_a6babee4ade7
is: Q9GZV3
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: SLC5A7
has only substance units: false
initial amount: NaN
is encoded by: hsa:60482

metaR CYTK1n
fast: false
product: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110021#

metaR MALSO4tm
reactant: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110021#
is described by: ECO:0000269
modifier: MODEL1310110021#
is: SBO:0000185
name: Malate:sulfate antiport, mitochondrial
type: Reaction
product: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f3c9c4b7_cad6_4f80_b9c6_77a737aed684
boundary condition: true
is: Q9H2X9
initial concentration: NaN
constant: false
name: SLC12A5
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:57468

metaM lald D c
is: CHEBI:17167
type: Species
name: (R)-lactaldehyde
constant: false
initial concentration: 1.0
is: HMDB06458
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_b557b6f1_c2ce_4214_8e95_1917cc00e2af
type: Species
is: P34896
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6470
is: SBO:0000252
name: SHMT1

metaM prostge1 e
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: prostaglandin E1(1-)
is: CHEBI:57397
is: HMDB01442
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

metaR TMDK1
is: SBO:0000176
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.21
name: thymidine kinase (ATP:thymidine)
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110021#

metaM glx x
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00119
type: Species
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: CHEBI:36655
boundary condition: false
name: glyoxylate

metaR SPHS1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
name: sphingosine-1-phosphate transport
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false

metaR RE1534M
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110021#
is: SBO:0000176
name: RE1534
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR r0999
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110021#
name: Facilitated diffusion
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR r0390
fast: false
is described by: ECO:0000000
reactant: MODEL1310110021#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reversible: true
is: SBO:0000176

metaR FAOXC165C164m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR EX HC02206 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin C1(1-) exchange
type: Reaction

metaM orn m
name: Ornithine
is: HMDB00214
is: CHEBI:46912
is: C01602
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_11b487c1_7264_4c49_aa6e_fab86325b3d9
is: SBO:0000252
initial concentration: NaN
is: B8ZZR8
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: GGCT
type: Species
is encoded by: hsa:79017

metaR NDP8
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.9
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110021#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110021#
name: nucleoside-diphosphatase (dUDP)
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_810e5bd9_cfd9_498f_ab69_56009afd5a51
initial amount: NaN
has only substance units: false
name: _642502_1_c
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:642502

metaR FAOXC16DCr
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR r2325
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110021#

metaM 12ppd R c
type: Species
name: (R)-propane-1,2-diol
is: CHEBI:28972
constant: false
boundary condition: false
is: HMDB01881
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110021#_bb4b6282_38a5_428e_802c_af307e7f5497
is encoded by: hsa:51733
constant: false
type: Species
name: UPB1
initial concentration: NaN
initial amount: NaN
is: B3KNC1
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM oagd3 hs g
is: CHEBI:58367
is: C00029
has only substance units: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
name: 9-O-Acetylated GD3
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00286
initial amount: NaN

metaM leuktrF4 e
initial concentration: 1.0
name: leukotriene F4
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: HMDB06465
is: CHEBI:27491
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_1195f813_40ed_47fc_960e_36bea5871d00
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10948
name: STARD3
is: B4DUY1
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_d029ad2b_0e64_43a5_aee6_354b6cc10196
is encoded by: hsa:5315
has only substance units: false
name: PKM2
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_42224e20_bf59_45bc_9710_124fc62bf064
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2678
constant: false
is: P19440
type: Species
name: GGT1
initial amount: NaN

metaM ser L c
type: Species
has only substance units: false
is: CHEBI:17115
name: L-serine
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_1095909b_7d32_46bc_95f2_6b36792a2dd9
is encoded by: hsa:26275
type: Species
name: HIBCH
is: Q6NVY1
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_efd90a59_4b09_4114_9953_d65c5b7c13d3
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: HK1
has only substance units: false
initial concentration: NaN
boundary condition: true
is: B3KXY9
is encoded by: hsa:3098

metaR r1652
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110021#
is: SBO:0000185
reactant: MODEL1310110021#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110021#
type: Reaction
reversible: true
product: MODEL1310110021#

metaM acgam c
name: N-acetyl-D-glucosamine
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17411
type: Species
is: HMDB00215
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN

metaM dcyt c
name: Deoxycytidine
is: HMDB00014
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: C00881
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_e5e8ab6e_14bd_4348_bdf1_5a7c2ae95ee6
is encoded by: hsa:6566
has only substance units: false
type: Species
is: B4DKS0
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC16A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_5b1ce65d_bd66_4655_bfc4_3c0a5c23f6aa
is encoded by: hsa:50814
has only substance units: false
boundary condition: true
is: Q15738
initial concentration: NaN
initial amount: NaN
type: Species
name: NSDHL
is: SBO:0000252
constant: false

metaM CE2417 m
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
type: Species
is: SBO:0000247
is: CHEBI:28387
constant: false
is: HMDB11123
has only substance units: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r0393
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110021#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
kinetic law: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_b60e03bf_1ae0_4e06_825e_db7e209c4387
has only substance units: false
initial concentration: NaN
name: SLC26A6
is: Q548A7
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:65010
initial amount: NaN
type: Species

metaM HC02206 c
initial concentration: 1.0
type: Species
is: CHEBI:57399
constant: false
name: prostaglandin C1(1-)
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR r2322
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR LSTO1r
reactant: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.21.6
reversible: false
name: Lathosterol oxidase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_89c9c6c3_f797_48fb_a6c1_850e9589ed8c
is: Q53YB7
is: SBO:0000252
is encoded by: hsa:1329
name: COX5B
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true

metaR LDH D
is version of: http://identifiers.org/ec-code/1.1.2.4
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
is: SBO:0000176
reversible: true
name: D-lactate dehydrogenase
is described by: ECO:0000304
type: Reaction

metaR NOt
product: MODEL1310110021#
name: NO transport (diffusion)
kinetic law: MODEL1310110021#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)

metaM 5htrp c
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00472
constant: false
is: CHEBI:17780
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
type: Species
name: 5-hydroxy-L-tryptophan
is: SBO:0000247
initial concentration: 1.0

metaM 2dr1p c
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB01351
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN
is: C00672
is: CHEBI:58576
is: SBO:0000247
boundary condition: false
name: 2-Deoxy-D-ribose 1-phosphate

metaR r1650
kinetic law: MODEL1310110021#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#

metaM ala B m
initial amount: NaN
is: SBO:0000247
name: beta-alanine
type: Species
constant: false
is: CHEBI:16958
is: HMDB00056
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
has only substance units: false

metaR r1926
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
fast: false
product: MODEL1310110021#
is: SBO:0000185

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR CHOLtn
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
type: Reaction
product: MODEL1310110021#
name: Choline transport, nuclear through pores
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
is described by: ECO:0000000

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR EX gumtchol LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for guar gum-taurocholic acid complex
type: Reaction

metaM 3decdicoa m
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: SBO:0000247
name: 3,7-decadienoylcoa
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966

metaR r2323
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
reversible: true

metaR PROSTGE2t2
reactant: MODEL1310110021#
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110021#
name: prostaglandin uniport

metaR TRDRm
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.9
is described by: ECO:0000269
reactant: MODEL1310110021#
is: SBO:0000176
name: thioredoxin reductase (NADPH)
reversible: false
kinetic law: MODEL1310110021#
fast: false
type: Reaction
modifier: MODEL1310110021#

metaR HDCAter
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110021#
name: palmitate ER export
kinetic law: MODEL1310110021#
reversible: false

metaM bilirub r
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:57977
constant: false
name: bilirubin(2-)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_d28336d0_74ec_4a90_af29_850e60ab634b
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: P43353
is encoded by: hsa:221
name: ALDH3B1
is: SBO:0000252

metaM leuktrF4 c
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:27491
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: HMDB06465
name: leukotriene F4

metaR ADA
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
is described by: ECO:0000269
reversible: false
type: Reaction
reactant: MODEL1310110021#
fast: false
name: Adenosine deaminase
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110021#

metaM ac e
constant: false
is: CHEBI:30089
type: Species
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00042
initial concentration: 1.0
name: acetate

http://identifiers.org/biomodels.db/MODEL1310110021#_23787d6e_28a7_4c66_81e7_8b9eafc283be
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:4645
boundary condition: true
is: Q9H6Y6
name: MYO5B
type: Species
initial amount: NaN

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR GCALDD
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
name: Glycolaldehyde dehydrogenase
reactant: MODEL1310110021#
is described by: ECO:0000304
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
product: MODEL1310110021#
fast: false
is: SBO:0000176
type: Reaction

metaR GTHPe
is: SBO:0000176
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
fast: false
type: Reaction
name: glutathione peroxidase (e)
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000269

metaM pan4p c
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C01134
initial amount: NaN
is: CHEBI:47942
constant: false
name: Pantetheine 4'-phosphate
is: HMDB01416

metaR r2328
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR SERDGLYexR
kinetic law: MODEL1310110021#
is: SBO:0000185
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000304
fast: false
modifier: MODEL1310110021#
name: D-Serine/Glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110021#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_bbcc1491_dcd5_47ea_9eff_913571b6f971
name: ACSS2
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: Q5QPH3
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:55902

metaR ACACtx
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
name: acetoacetate intracellular transport unknown mechanism
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
fast: false

metaR FACOAL80i
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
name: fatty-acid--CoA ligase (octanoate)
kinetic law: MODEL1310110021#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110021#
reactant: MODEL1310110021#
reversible: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR THRGLNexR
is: SBO:0000185
reactant: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
is described by: ECO:0000304
product: MODEL1310110021#
name: L-threonine/glycine reversible exchange
reversible: true
modifier: MODEL1310110021#

metaR CYTK3
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (CMP)(GTP)
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_6221ff34_e574_43e0_a700_5247b017cd2d
is encoded by: hsa:6579
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: P46721
initial amount: NaN
name: SLCO1A2

metaR OMPDC
is described by: ECO:0000269
kinetic law: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.10
name: orotidine-5'-phosphate decarboxylase
product: MODEL1310110021#
reversible: false
modifier: MODEL1310110021#

metaR DCYTDn
reactant: MODEL1310110021#
name: deoxycytidine deaminase, nuclear
type: Reaction
is described by: ECO:0000254
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
product: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110021#_ac10caae_08a3_4af6_9ef5_e175e41c098e
boundary condition: true
is encoded by: hsa:5293
type: Species
name: PIK3CD
constant: false
initial concentration: NaN
is: SBO:0000252
is: A7E2E0
has only substance units: false
initial amount: NaN

metaM omhpal r
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB06294
name: w-hydroxypalmiticacid
initial amount: NaN
boundary condition: false
notes: FORMULA: C16H30O3 CHARGE: -1

metaR EX 4hdebrisoquine LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4 hydroxy debrisoquine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_f7ba0716_f9fa_4882_a270_7342b29c5e51
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: E7EPT3
has only substance units: false
type: Species
is encoded by: hsa:501
constant: false
initial concentration: NaN
name: ALDH7A1

metaR SMS
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.27
name: Sphingomyelin synthase (homo sapiens)
reactant: MODEL1310110021#
is described by: ECO:0000269
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#

metaR r0841
name: Free diffusion
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.271
reactant: MODEL1310110021#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_eb6693ae_0f41_43ba_87d4_eadbfc43fd87
is: Q6TCH8
constant: false
is: SBO:0000252
name: ME3
type: Species
is encoded by: hsa:10873
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

metaM idp c
name: IDP(3-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
is: CHEBI:58280
type: Species
is: HMDB03335
constant: false

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR RE1523M
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1523

http://identifiers.org/biomodels.db/MODEL1310110021#_3ba84b5d_c017_445a_9f63_6eef89e2372e
type: Species
has only substance units: false
is encoded by: hsa:AI926493
constant: false
boundary condition: true
initial amount: NaN
name: _AI926493_1_m
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_d7c027ea_fbd0_4605_9b59_8e4b391f4973
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: _BE042354_1_m
is encoded by: hsa:BE042354
initial amount: NaN

metaR CYOOm3
fast: false
reactant: MODEL1310110021#
reversible: false
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
name: cytochrome c oxidase, mitochondrial Complex IV
is version of: http://identifiers.org/ec-code/1.9.3.1
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
type: Reaction
kinetic law: MODEL1310110021#

metaM meoh c
name: methanol
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01875
boundary condition: false
is: CHEBI:17790
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_54d4a3cc_2fe6_4985_bc13_611fcea032f3
name: ENTPD4
boundary condition: true
type: Species
is: Q9Y227
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:9583
has only substance units: false
is: SBO:0000252

metaM formcoa x
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB03419
is: CHEBI:57376
name: formyl-CoA(4-)
notes: FORMULA: C22H32N7O17P3S CHARGE: -4 INCHI: InChI=1S/C22H36N7O17P3S/c1-22(2,17(33)20(34)25-4-3-13(31)24-5-6-50-11-30)8-43-49(40,41)46-48(38,39)42-7-12-16(45-47(35,36)37)15(32)21(44-12)29-10-28-14-18(23)26-9-27-19(14)29/h9-12,15-17,21,32-33H,3-8H2,1-2H3,(H,24,31)(H,25,34)(H,38,39)(H,40,41)(H2,23,26,27)(H2,35,36,37)/p-4/t12-,15-,16-,17+,21-/m1/s1 EHMN_ABBREVIATION: C00798
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_54ad21b3_98a5_4e66_be49_83fb8dd0084f
is encoded by: hsa:231
name: AKR1B1
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: P15121
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_3607c9da_7e6e_4e1a_8fe2_410d1d946a2a
is encoded by: hsa:10998
is: SBO:0000252
is: Q9Y2P5
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC27A5
boundary condition: true
type: Species

metaR r2329
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110021#
is: SBO:0000185

metaM 3hpp m
is: CHEBI:16510
boundary condition: false
initial amount: NaN
name: 3-hydroxypropionate
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00700
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013

metaR ALADGLNexR
modifier: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110021#
name: L-alanine/glutamine reversible exchange
product: MODEL1310110021#

metaR r1850
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110021#
reactant: MODEL1310110021#
name: Y+LAT2 Utilized transport
product: MODEL1310110021#

metaR CERT1rt
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110021#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#
name: ceramide transport protein
reactant: MODEL1310110021#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
product: MODEL1310110021#

metaR CYTK2
is: SBO:0000176
product: MODEL1310110021#
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
name: cytidylate kinase (dCMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110021#

metaR r0281
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/5.3.1.6
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176

metaM glyc R c
has only substance units: false
name: D-glycerate
type: Species
is: CHEBI:16659
boundary condition: false
is: HMDB00139
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

metaM gm3 hs g
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
boundary condition: false
is: SBO:0000247
is: CHEBI:60065

metaR r0842
type: Reaction
name: Postulated transport reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.3.1.72
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_b5669950_5f96_421b_9586_a4c9ed36e189
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: SLC38A3
initial amount: NaN
has only substance units: false
is encoded by: hsa:10991
is: SBO:0000252
is: Q99624

metaM CE4874 c
type: Species
name: 5beta-cholestane-3alpha,7alpha,12alpha,27,27-pentaol
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H48O5 CHARGE: 0 INCHI: InChI=1/C27H48O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-25,28-32H,5-14H2,1-4H3/t15-,16u,17-,18+,19-,20-,21-,22+,23-,24-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4874
boundary condition: false
is: CHEBI:57923

metaR 4MOPt2im
type: Reaction
reactant: MODEL1310110021#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
is described by: ECO:0000000
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false

metaM ac c
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: CHEBI:30089
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: acetate
is: HMDB00042

metaR r1548
is: SBO:0000185
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR PRDX
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
name: Peroxidase (multiple substrates)
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.11.1.7
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
is: SBO:0000176
modifier: MODEL1310110021#

metaM 1pyr5c c
initial amount: NaN
boundary condition: false
is: C03912
name: 1-Pyrroline-5-carboxylate
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01301
is: SBO:0000247
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: CHEBI:15893
constant: false

metaR r2326
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR ORPT
fast: false
modifier: MODEL1310110021#
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
reactant: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: orotate phosphoribosyltransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10

metaM succ m
name: Succinate
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
is: HMDB00254
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: C00042
type: Species
initial concentration: 1.0
has only substance units: false

metaR 3HKYNAKGAT
is described by: ECO:0000304
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
fast: false
reversible: false
modifier: MODEL1310110021#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.7
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

metaM pe hs m
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16038
has only substance units: false
name: phosphatidylethanolamine
boundary condition: false
type: Species

metaR DGTPtm
name: transport of dGTP into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#
fast: false

metaR CYTK5
is: SBO:0000176
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
name: cytidylate kinase (dCMP)
is described by: ECO:0000269
reactant: MODEL1310110021#
type: Reaction
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110021#_765d923a_69b5_4106_8cc6_89ed05244bb9
initial concentration: NaN
boundary condition: true
name: PC
is encoded by: hsa:5091
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_d5342e44_3c5d_4e9a_a089_e294cf16bb92
is: B4DYG5
is encoded by: hsa:5297
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: PI4KA
initial amount: NaN
is: SBO:0000252

metaM retinal cis 13 r
is: CHEBI:45487
initial concentration: 1.0
initial amount: NaN
name: 13-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
has only substance units: false
boundary condition: false
constant: false
is: HMDB06220
type: Species
is: SBO:0000247

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaM glx m
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:36655
name: glyoxylate
initial amount: NaN
is: HMDB00119
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_169d6e8e_7764_41ca_b003_f17635b5f375
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: VNN3
is: SBO:0000252
type: Species
is encoded by: hsa:55350

metaR r1549
reactant: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dhcholestanate m
type: Species
constant: false
has only substance units: false
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: CHEBI:16577
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR r2327
reactant: MODEL1310110021#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ser L e
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
has only substance units: false
name: L-serine
is: HMDB00187
initial amount: NaN
is: CHEBI:17115
initial concentration: 1.0
constant: false

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR EX npthl LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Naphthalene exchange
type: Reaction

metaM meoh e
constant: false
is: HMDB01875
name: methanol
initial concentration: 1.0
has only substance units: false
is: CHEBI:17790
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132

metaR FAOXC61C4m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR RE1836X
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.176
name: RE1836
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
product: MODEL1310110021#

metaR DGTPtn
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dGTP diffusion in nucleus
is: SBO:0000185
kinetic law: MODEL1310110021#

metaR CYTK4
fast: false
product: MODEL1310110021#
is described by: ECO:0000269
modifier: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
name: cytidylate kinase (dCMP)(GTP)
reactant: MODEL1310110021#
is: SBO:0000176

metaR LEUKTRA4t
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reversible: true
product: MODEL1310110021#
name: leukotriene A4 transport

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR L LACt2r
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
name: L-lactate reversible transport via proton symport
is described by: ECO:0000269
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reversible: true
is: SBO:0000185
type: Reaction

metaR r0840
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
fast: false
is: SBO:0000185
name: Free diffusion
is version of: http://identifiers.org/ec-code/1.14.13.70
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_1cd9dc21_b623_42f4_93f8_5c97e8067cde
is encoded by: hsa:W74642
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: _W74642_1_c

metaM pail45p hs c
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
has only substance units: false
is: CHEBI:28910
constant: false
initial concentration: 1.0
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate

metaR PE HSter
is described by: ECO:0000000
name: phosphatidylethanolamine scramblase
kinetic law: MODEL1310110021#
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_6dbf0a05_d096_418e_8054_ba753517101d
has only substance units: false
name: SRD5A2
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:6716
initial concentration: NaN
boundary condition: true
is: P31213

metaM thmpp c
initial amount: NaN
is: SBO:0000247
is: CHEBI:45931
has only substance units: false
constant: false
is: C00068
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
is: HMDB01372
initial concentration: 1.0
boundary condition: false
type: Species
name: Thiamine diphosphate

metaM atp r
is: CHEBI:57299
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: ATP(4-)
constant: false
initial amount: NaN
is: C00002
is: SBO:0000247
is: HMDB00538

metaM dhcholestanate r
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00359
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
boundary condition: false
has only substance units: false
constant: false
type: Species

metaM cspg c l
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
type: Species
initial amount: NaN
is: HMDB02183
is: CHEBI:36005
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
has only substance units: false
boundary condition: false

metaR DNDPt11m
type: Reaction
modifier: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000269
name: dADP transport via dGDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
fast: false
reactant: MODEL1310110021#

metaR GLCter
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD

metaR CHSTEROLt2
name: cholesterol intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#

metaM sucsal m
boundary condition: false
is: CHEBI:57706
initial amount: NaN
initial concentration: 1.0
name: Succinic semialdehyde
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: HMDB01259
type: Species
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_5bb8cbf5_2cf4_4916_b78c_f0a1b314db36
name: SLC6A14
is encoded by: hsa:11254
is: SBO:0000252
constant: false
has only substance units: false
is: Q9UN76
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r1764
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
fast: false
modifier: MODEL1310110021#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false

metaM fald e
name: formaldehyde
constant: false
initial concentration: 1.0
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:16842
initial amount: NaN
is: HMDB01426

metaM 3mob e
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial concentration: 1.0
is: CHEBI:11851
type: Species
constant: false
boundary condition: false
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
has only substance units: false
is: HMDB00019
initial amount: NaN

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_fa63d6f9_a9ce_47b9_a0ad_7e9a7749f8be
type: Species
initial concentration: NaN
name: NDUFA13
boundary condition: true
constant: false
is: Q9P0J0
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:51079

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_e9df9789_8d45_48c0_b4a3_eb0ba578caaa
initial concentration: NaN
boundary condition: true
is: O15327
name: INPP4B
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8821
constant: false
type: Species

metaR CYTK7
is: SBO:0000176
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110021#
type: Reaction
reversible: true
name: cytidylate kinase (CMP,UTP)
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM vitd3 c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00876
name: calciol
is: CHEBI:28940
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM HC01496 m
initial amount: NaN
is: SBO:0000247
name: 2-Amino-3-oxoadipate
is: CHEBI:28095
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false

metaM HC01459 x
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
is: CHEBI:27458
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_2015119f_76f0_4db0_a818_17a92ef386f7
name: RDH13
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:112724
is: B3KVA3
constant: false

metaR r0055
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
reversible: true
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
fast: false
type: Reaction
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.4.2.7
product: MODEL1310110021#
is described by: ECO:0000000
reactant: MODEL1310110021#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_6cb0112a_01e1_4992_87fb_59a3d5778225
boundary condition: true
name: PRDX2
is encoded by: hsa:7001
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN

metaR P45027A1m
is described by: ECO:0000269
product: MODEL1310110021#
name: Cytochrome P450 27
reversible: false
modifier: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_41d17135_8b05_4034_a06d_5a83674e3c05
initial amount: NaN
is: P41222
boundary condition: true
is encoded by: hsa:5730
constant: false
initial concentration: NaN
name: PTGDS
is: SBO:0000252
type: Species
has only substance units: false

metaR RE2541E
reversible: true
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
reactant: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
product: MODEL1310110021#
is described by: ECO:0000000
name: RE2541
modifier: MODEL1310110021#
is: SBO:0000176

metaM fald c
boundary condition: false
name: formaldehyde
has only substance units: false
initial concentration: 1.0
is: HMDB01426
is: CHEBI:16842
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067

metaR r0616
product: MODEL1310110021#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false

metaM atp x
type: Species
boundary condition: false
initial amount: NaN
constant: false
name: ATP(4-)
is: HMDB00538
is: C00002
is: SBO:0000247
is: CHEBI:57299
has only substance units: false
initial concentration: 1.0

metaR CHSTEROLt1
reactant: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000304
fast: false
product: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
name: cholesterol intracellular transport

metaR CYTK6
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
fast: false
is described by: ECO:0000269
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is: SBO:0000176

metaR FAOXC6C4m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)m
type: Reaction

metaR r1007
product: MODEL1310110021#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion

metaR RE0453C
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
fast: false
product: MODEL1310110021#

metaR LDH L
modifier: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
name: L-lactate dehydrogenase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is described by: ECO:0000000
reversible: true

metaM tdchola x
boundary condition: false
has only substance units: false
name: taurochenodeoxycholate
is: HMDB00951
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:9407

metaM pan4p e
is: HMDB01416
notes: FORMULA: C11H21N2O7PS CHARGE: -2
initial amount: NaN
is: C01134
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:47942
constant: false
type: Species
name: Pantetheine 4'-phosphate

http://identifiers.org/biomodels.db/MODEL1310110021#_e98c6bac_f543_4e70_86a1_7e087b5f84c4
initial amount: NaN
is: Q15274
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:23475
name: QPRT
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_aab6bc0a_0a90_499c_a08a_1d7f9078dc8a
name: ACPP
is: SBO:0000252
is: P15309
is encoded by: hsa:55
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR CYTK9
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
name: cytidylate kinase (CMP,dCTP)
kinetic law: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110021#
is: SBO:0000176

metaR PMEVKx
reactant: MODEL1310110021#
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.2
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
is: SBO:0000176
name: phosphomevalonate kinase
reversible: false
type: Reaction

metaR HEX1
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.1
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
is described by: ECO:0000134
name: hexokinase (D-glucose:ATP)

metaM 3mob c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: CHEBI:11851
type: Species
boundary condition: false
has only substance units: false
name: 3-methyl-2-oxobutanoate
constant: false
is: SBO:0000247
is: HMDB00019

http://identifiers.org/biomodels.db/MODEL1310110021#_4dee4ca9_ee4d_43c2_9b7f_a50a06270a6b
is: Q9H6Y6
is encoded by: hsa:4645
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: MYO5B
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR UMPK5n
modifier: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: UMP kinase (dATP),nuclear
is described by: ECO:0000269

metaR r1008
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
type: Reaction
reversible: false
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_1debaef0_1cad_453c_8e90_62825baf47cc
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: Q96KJ9
name: COX4I2
initial amount: NaN
is encoded by: hsa:84701
is: SBO:0000252

metaM 6pgc r
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
boundary condition: false
constant: false
name: 6-phosphonatooxy-D-gluconate
initial amount: NaN
initial concentration: 1.0
is: HMDB01316
is: SBO:0000247
has only substance units: false
is: CHEBI:58759
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_1dafbac2_c44e_4130_a825_e584337364ba
initial concentration: NaN
is encoded by: hsa:1956
constant: false
boundary condition: true
is: SBO:0000252
name: EGFR
is: P00533
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c0c0806a_bf41_46a3_9558_c9fe1dd92e02
constant: false
is: P00492
is: SBO:0000252
boundary condition: true
name: HPRT1
is encoded by: hsa:3251
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_a8f82bbc_176a_4683_aa6c_b21edb3de6bf
is encoded by: hsa:64077
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
name: LHPP
has only substance units: false
type: Species
is: Q9H008

http://identifiers.org/biomodels.db/MODEL1310110021#_bf1cd034_1739_4fa7_8f02_5c6e53aae16b
boundary condition: true
is: Q9NPC4
name: A4GALT
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:53947
is: SBO:0000252
type: Species

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: (S)-Hydroxydecanoyl-CoA
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: CHEBI:28325

metaM arachdcrn c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57387
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB01322
name: C20:4 carnitine

metaM idp e
name: IDP(3-)
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58280
constant: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335

metaR H2Otp
reactant: MODEL1310110021#
fast: false
name: H2O transport, peroxisomal
is: SBO:0000185
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_73322ce4_67e9_45ef_994f_66cffcf81d1a
is encoded by: hsa:1103
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CHAT
type: Species
initial concentration: NaN
is: Q6LEN6

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM mescon m
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
has only substance units: false
is: HMDB00749
name: Mesaconate
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:36986

http://identifiers.org/biomodels.db/MODEL1310110021#_34bb7656_22d8_4113_8e97_810df10edcf9
initial concentration: NaN
name: NDUFB7
has only substance units: false
is encoded by: hsa:4713
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is: P17568
boundary condition: true

metaR ARACHDt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_4b258967_0306_4afe_b030_c00ccf91b433
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: PANK1
initial amount: NaN
is encoded by: hsa:53354
type: Species
is: Q8TE04

metaM dmnoncrn m
initial concentration: 1.0
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: 4,8 dimethylnonanoyl carnitine
type: Species

metaR CYTK8
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dATP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#

metaR r0541
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
reactant: MODEL1310110021#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110021#

metaR r0614
reactant: MODEL1310110021#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
is: SBO:0000176
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_4cbaa9e9_eeb8_4688_b10f_2d426b44c523
initial amount: NaN
name: SLC26A7
is: Q8TE54
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:115111
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_6f8ff50a_fdef_4e9e_8f93_5e57c8c055d3
initial concentration: NaN
type: Species
name: ALDH3B2
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:222
constant: false
is: P48448
has only substance units: false

metaM spc hs c
is: http://identifiers.org/pubchem.compound/5311445
has only substance units: false
name: sphingosylphosphorylcholine
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_6727eaa4_e466_43f0_8199_3b4a1e27f078
is encoded by: hsa:5172
has only substance units: false
boundary condition: true
is: O43511
name: SLC26A4
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM rib D c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00283
constant: false
name: D-ribose
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false

metaM rbt e
constant: false
is: CHEBI:15963
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00508
name: D-ribitol
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_efcd2b98_3bec_45ed_9ead_fd4c0051258d
constant: false
initial concentration: NaN
name: SLC26A9
has only substance units: false
type: Species
is: B3KXK1
is encoded by: hsa:115019
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_c80f7eb9_afca_46ce_bdef_6ad25366d297
name: ACLY
constant: false
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:47
is: SBO:0000252
is: P53396
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_7fd4c6db_6a31_4e23_932b_238fb8a30823
is encoded by: hsa:2222
initial amount: NaN
initial concentration: NaN
is: P37268
name: FDFT1
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species

metaM dsT antigen g
constant: false
is: CHEBI:16497
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
name: disialyl-T antigen
notes: FORMULA: C36H56N3O26X CHARGE: -2
is: HMDB01440
has only substance units: false

metaR ADRNt
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110021#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110021#
is described by: ECO:0000000

metaM srtn e
constant: false
boundary condition: false
is: HMDB00259
is: SBO:0000247
name: serotonin(1+)
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
is: CHEBI:350546
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM 3mlda c
type: Species
boundary condition: false
has only substance units: false
is: HMDB02820
initial concentration: 1.0
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
initial amount: NaN
name: 3-Methylimidazoleacetic acid
is: http://identifiers.org/pubchem.compound/8122
constant: false
is: SBO:0000247
is: C05828

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
initial concentration: 1.0
has only substance units: false
is: CHEBI:10986
constant: false
is: C03492
type: Species
name: D-4'-Phosphopantothenate
boundary condition: false
is: HMDB01016
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_a34a6c7f_1808_4fdc_8a0a_c40c631e078f
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2687
is: P36269
name: GGT5
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_9b11742a_4541_4e37_9831_86c511b9eea6
has only substance units: false
is encoded by: hsa:5286
constant: false
is: O00443
is: SBO:0000252
name: PIK3C2A
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaR ILETA
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
name: isoleucine transaminase
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#

metaR CERT1gt
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.11.1
kinetic law: MODEL1310110021#
fast: false
name: ceramide transport protein
is: SBO:0000185
reversible: true
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

metaR FMNAT
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.7.2
product: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
name: FMN adenylyltransferase
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y

metaR H2Otg
kinetic law: MODEL1310110021#
reversible: true
name: H2O transport, Golgi apparatus
type: Reaction
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_0a569c54_1ce5_4c6b_aaa3_33222886ca08
is: Q9NRZ5
boundary condition: true
is encoded by: hsa:56895
constant: false
name: AGPAT4
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaR r2435
type: Reaction
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110021#
reversible: false
product: MODEL1310110021#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_ef03e9bb_f3a2_4edc_9bed_71168691eaf0
boundary condition: true
name: ST3GAL1
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:6482
is: SBO:0000252
type: Species
has only substance units: false
is: Q11201

metaR FAOXC164GC163m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaM mlthf c
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
type: Species
is: HMDB01533
is: CHEBI:15636
has only substance units: false
name: 5,10-Methylenetetrahydrofolate
initial amount: NaN
is: C00143
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_53f4ab88_fbf0_41f1_b591_6afa6d8b0f2b
initial amount: NaN
name: KHK
initial concentration: NaN
is: P50053
is encoded by: hsa:3795
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_e424920a_a3a0_4b9b_8df1_096898c0f630
initial amount: NaN
constant: false
is: Q8TET4
is: SBO:0000252
type: Species
is encoded by: hsa:2595
initial concentration: NaN
boundary condition: true
name: GANC
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_65324e1f_7f64_4279_9c62_3b6416a9728e
is: Q9BZQ4
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:23057
has only substance units: false
is: SBO:0000252
name: NMNAT2

http://identifiers.org/biomodels.db/MODEL1310110021#_f9c0551e_99fb_4a26_9ce6_cc855ba00019
initial concentration: NaN
type: Species
is encoded by: hsa:10400
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: PEMT
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_57dfe867_f9bb_4400_aabd_25e26fda4427
name: ALPI
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: P09923
is encoded by: hsa:248
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_318bb4b2_0b60_4cca_bf92_da2193740065
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
name: MTMR6
has only substance units: false
is: Q9Y217
is encoded by: hsa:9107

metaM 3dhguln c
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
name: 3-dehydro-L-gulonate
boundary condition: false
is: SBO:0000247
is: CHEBI:57655
initial concentration: 1.0
constant: false
is: HMDB06334
type: Species
has only substance units: false

metaM arachdcoa m
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
is: CHEBI:57368
is: HMDB06523
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)

metaR r2508
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110021#
type: Reaction
name: Utilized transport
reversible: true
product: MODEL1310110021#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

metaM ppcoa m
initial amount: NaN
is: HMDB01275
name: Propanoyl-CoA
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: CHEBI:57392
constant: false
type: Species
is: C00100

http://identifiers.org/biomodels.db/MODEL1310110021#_c2a3bce9_ffbf_4d1c_9f4d_b4a916ee4b71
is: Q15111
initial amount: NaN
name: PLCL1
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:5334
constant: false

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_830382cc_d8e7_42f5_91b3_7befc2f9b403
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: HSD17B7
initial concentration: NaN
is encoded by: hsa:51478
is: P56937
type: Species

metaR DCSPTN1CPT2
reversible: false
name: carnitine transferase
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110021#
fast: false
type: Reaction
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM rib D e
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:16988
name: D-ribose
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB00283

metaR TREHe
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
name: alpha,alpha-trehalase
kinetic law: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.1.28
is: SBO:0000176
modifier: MODEL1310110021#
type: Reaction
product: MODEL1310110021#

metaR D LACt2
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
reversible: true
name: D-lactate transport via proton symport
modifier: MODEL1310110021#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_391c5452_5ad1_4f60_98f8_c354cd9a0146
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:26062
initial concentration: NaN
name: HYALP1

http://identifiers.org/biomodels.db/MODEL1310110021#_12e456fe_0afd_405a_86cc_e8300780608f
type: Species
is encoded by: hsa:10400
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: PEMT
is: SBO:0000252
has only substance units: false

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR GK1
is version of: http://identifiers.org/ec-code/2.7.4.8
name: guanylate kinase (GMP:ATP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110021#
is: SBO:0000176
modifier: MODEL1310110021#
reversible: true
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_c66a78e3_8610_410f_9bf8_7388c2b1b59b
is encoded by: hsa:195814
initial amount: NaN
has only substance units: false
is: B3KT84
constant: false
type: Species
initial concentration: NaN
name: SDR16C5
boundary condition: true
is: SBO:0000252

metaR r0539
reversible: true
kinetic law: MODEL1310110021#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34

metaM ps hs e
initial concentration: 1.0
is: CHEBI:18303
has only substance units: false
name: phosphatidylserine
constant: false
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species
is: SBO:0000247
boundary condition: false

metaR RBTt
name: ribitol transport via passive diffusion
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
product: MODEL1310110021#
is: SBO:0000185
fast: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000

metaM 3mlda e
has only substance units: false
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
constant: false
is: SBO:0000247
is: HMDB02820
is: C05828
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3-Methylimidazoleacetic acid
is: http://identifiers.org/pubchem.compound/8122
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_53cf8a0b_1c2f_4fa9_963b_47a156aa3801
constant: false
is encoded by: hsa:29925
name: GMPPB
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r2509
reversible: true
reactant: MODEL1310110021#
name: Utilized transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_2ce265ed_5316_4b8e_8de6_4d1f222de49f
name: DLAT
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1737
initial concentration: NaN
is: Q86YI5
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_cac37652_5c64_4495_9225_f29b49fbbdb2
boundary condition: true
is: P22392
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4831
initial amount: NaN
constant: false
name: NME2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_b6ac1608_9ff4_42a6_a130_2ee2f4972d87
type: Species
boundary condition: true
is encoded by: hsa:883
has only substance units: false
constant: false
name: CCBL1
is: Q16773
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_2efb427a_8899_4294_897e_509e5a96cd54
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8854
is: O94788
has only substance units: false
initial amount: NaN
name: ALDH1A2
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_ed3099a6_1511_4d5c_8ddc_bd5960f91912
is encoded by: hsa:79646
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: PANK3
boundary condition: true
is: Q9H999

metaR DCSPTN1CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
name: carnitine O-palmitoyltransferase
is: SBO:0000176
modifier: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110021#

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR FAOXC101C102m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR PVD3
is: SBO:0000176
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
fast: false
name: Previtamin D3 formation
is described by: ECO:0000134
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_262c7755_cca8_4837_b44d_7d993f6c85ca
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI291895
boundary condition: true
name: _AI291895_1_c
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaR DNDPt15m
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110021#
reactant: MODEL1310110021#
name: dUDP transport via dGDP antiport
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_85323458_3271_4807_8acb_6de906f98850
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:AI345944
boundary condition: true
has only substance units: false
name: _AI345944_1_m
type: Species

metaR XOLDIOLONEt
is: SBO:0000185
kinetic law: MODEL1310110021#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110021#
name: lipid, flip-flop intracellular transport

metaR NADPtru
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
name: NADP transporter, endoplasmic reticulum
kinetic law: MODEL1310110021#
is: SBO:0000185
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c9ce0fdf_092e_40e0_ac60_0b8eb2de5944
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI191472
has only substance units: false
name: _AI191472_1_c
boundary condition: true

metaR r1167
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
name: EC:2.3.1.26
reversible: false

metaR C3STKR2r
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110021#
reactant: MODEL1310110021#
name: C-3 sterol keto reductase (zymosterol)
type: Reaction
reversible: false
fast: false
product: MODEL1310110021#
is described by: ECO:0000134
kinetic law: MODEL1310110021#
is: SBO:0000176

metaM amp c
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: HMDB00045
constant: false
type: Species
boundary condition: false
name: AMP
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00020
initial amount: NaN
is: CHEBI:3322

metaR r0911
reversible: true
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
is: SBO:0000185

metaR HEX7
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
type: Reaction
name: hexokinase (D-fructose:ATP)
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
reversible: false
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.1

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaM n2m2nmasn l
is: SBO:0000247
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
has only substance units: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: C04946
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR r2506
product: MODEL1310110021#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Utilized transport
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
kinetic law: MODEL1310110021#

metaR r0267
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.5.1.9
reversible: true
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_227881fa_4c4b_4c3a_9d98_18129e3a80b8
is: SBO:0000252
has only substance units: false
is encoded by: hsa:284273
name: ZADH2
is: Q4G1C4
boundary condition: true
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM HC01223 m
type: Species
is: SBO:0000247
is: CHEBI:57340
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
constant: false
initial concentration: 1.0
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
initial amount: NaN
has only substance units: false

metaR NADNe
is version of: http://identifiers.org/ec-code/3.2.2.5
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
name: NAD nucleosidase,extracellular
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.5 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:
reactant: MODEL1310110021#
type: Reaction
fast: false
modifier: MODEL1310110021#

metaM cytd e
initial amount: NaN
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: C00475
name: Cytidine
is: SBO:0000247
is: HMDB00089
is: CHEBI:17562

metaR HEX4
type: Reaction
product: MODEL1310110021#
reversible: false
fast: false
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.1.2
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.1
name: hexokinase (D-mannose:ATP)
reactant: MODEL1310110021#
is described by: ECO:0000304

metaR ADNK1m
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
name: adenosine kinase, mitochondrial
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_a2b8f19c_e9f5_4f2b_8e56_c7dd66d16456
type: Species
has only substance units: false
is: SBO:0000252
name: _AI769281_1_e
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AI769281

http://identifiers.org/biomodels.db/MODEL1310110021#_41850a4b_f7e0_4826_ae5a_2bde27f7a012
constant: false
is encoded by: hsa:10449
is: P42765
initial concentration: NaN
type: Species
initial amount: NaN
name: ACAA2
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR RE2649M
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
product: MODEL1310110021#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110021#
name: RE2649
reversible: true
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.2.2

metaR UDPGALtg
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
type: Reaction
is: SBO:0000185
reversible: true
name: UDP-Gal Golgi transport via CMP antiport
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_0f9ad16e_ae90_483a_abcf_205de62fcd52
has only substance units: false
name: ETFA
is encoded by: hsa:2108
constant: false
is: P13804
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR H2O2t
reactant: MODEL1310110021#
name: hydrogen peroxide transport via diffusion
type: Reaction
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reversible: true
is: SBO:0000185

metaR Q10H2e
name: transport of ubiquinol into lymph
kinetic law: MODEL1310110021#
type: Reaction
reversible: true
reactant: MODEL1310110021#
fast: false
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.

http://identifiers.org/biomodels.db/MODEL1310110021#_3f7777dd_597c_4036_b5ae_d5999a5c0f0f
is: Q5FC00
is: SBO:0000252
boundary condition: true
is encoded by: hsa:765
name: CA6
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_1d00eee0_e45e_469d_92e5_74f161096428
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q9NVS9
constant: false
has only substance units: false
type: Species
name: PNPO
is encoded by: hsa:55163

metaR FAOXC101m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_928a3a6f_5169_423b_a23d_0553ef946b36
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:728441
name: GGT2
boundary condition: true

metaR r0268
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
fast: false
reversible: true
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.3.1
product: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110021#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2

metaR NACHEXA3ly
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
name: beta-N-acetylhexosaminidase A, lysosomal

metaR r2507
reactant: MODEL1310110021#
fast: false
name: Utilized transport
is described by: ECO:0000000
product: MODEL1310110021#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
kinetic law: MODEL1310110021#

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR r1576
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110021#
fast: false

metaR 4HPRO LTte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110021#
name: Transport of trans-4-hydroxy-L-proline
fast: false
reactant: MODEL1310110021#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000134
type: Reaction

metaR NADPNe
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.2.2.5
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000269
name: NADP nucleosidase,extracellular
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (952.1) SUBSYSTEM: NAD metabolism EC Number: 3.2.2.6 Confidence Level: 4 AUTHORS: PMID:8394137 NOTES:See EC 3.2.2.5 for NAD nucleosidase
fast: false

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM abt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN
boundary condition: false
is: HMDB01851
name: L-arabinitol
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:18403

metaM crvnc c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB02183
is: SBO:0000247
constant: false
initial amount: NaN
name: cervonic acid, C22:6 n-3
notes: FORMULA: C22H31O2 CHARGE: -1
is: CHEBI:36005
type: Species

metaM HC01231 c
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
name: N-[(R)-pantothenoyl]-L-cysteinate
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:58480

metaM stcoa c
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57394
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
has only substance units: false
is: C00412
is: HMDB01114
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_aa60aaea_8f31_4a89_91a6_08f00ecd9ce1
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:64064
constant: false
is: Q9BYC2
name: OXCT2
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR RE3346C
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
name: RE3346
is: SBO:0000176
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:

metaM tcynt c
has only substance units: false
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
constant: false
type: Species
initial amount: NaN
name: thiocyanate
is: CHEBI:18022
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR CYSTA
reversible: true
is described by: ECO:0000304
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110021#
name: cysteine transaminase

http://identifiers.org/biomodels.db/MODEL1310110021#_21495434_7166_48dd_8dbb_f4695cb19cbe
name: SLC25A2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q9BXI2
boundary condition: true
is encoded by: hsa:83884
type: Species
initial amount: NaN

metaM cmpacna c
initial concentration: 1.0
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false
is: CHEBI:57812
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM sucr e
type: Species
is: HMDB00258
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
name: Sucrose
is: C00089
is: SBO:0000247
is: CHEBI:17992
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR H2Otn
is: SBO:0000185
name: H2O transport, nuclear
product: MODEL1310110021#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR RE1573M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
is: SBO:0000176
name: RE1573

metaR r1579
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
product: MODEL1310110021#
fast: false
is: SBO:0000185

metaR ADAe
kinetic law: MODEL1310110021#
type: Reaction
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
name: Adenosine deaminase, extracellular
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.4
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT

metaM srtn c
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
name: serotonin(1+)
is: HMDB00259
initial concentration: 1.0
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: CHEBI:350546
has only substance units: false
boundary condition: false

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR r0051
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
modifier: MODEL1310110021#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reactant: MODEL1310110021#
reversible: true
fast: false
is described by: ECO:0000000

metaM spc hs e
initial concentration: 1.0
name: sphingosylphosphorylcholine
is: SBO:0000247
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/5311445
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_153eb219_b672_4aec_81e2_aef0413d5b16
initial concentration: NaN
boundary condition: true
type: Species
name: _AD000092_1_c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AD000092
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_98457610_0b4c_4e00_b304_6d7d27584355
is encoded by: hsa:11343
name: MGLL
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: B2ZGL7
initial amount: NaN
has only substance units: false

metaR DTDPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
name: dTDP nuclear transport
is: SBO:0000185
fast: false
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_2990d6a3_428c_44c3_b84a_1f7f6b97bf8e
name: _HG2846_HT2983_1_m
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:HG2846-HT2983
type: Species
initial amount: NaN

metaM HC01397 x
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402
constant: false
has only substance units: false
type: Species
name: (S)-3-Hydroxyhexadecanoyl-CoA
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_2b996939_19af_45ba_914c_623b20d7def6
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
name: GCK
is: P35557
is encoded by: hsa:2645
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_c9152b05_d8a4_49a2_82d9_e7d73ef5828c
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: O15254
initial concentration: NaN
constant: false
name: ACOX3
is encoded by: hsa:8310
type: Species

metaR ASPTAm
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
is: SBO:0000176
product: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
name: aspartate transaminase
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
reversible: true

metaR H2Otm
is described by: ECO:0000269
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
kinetic law: MODEL1310110021#
name: H2O transport, mitochondrial
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
is: SBO:0000185
type: Reaction

metaR COAtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110021#
is: SBO:0000185
reversible: true
name: CoA transport in Golgi via diffusion
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000
type: Reaction

metaR r1578
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000

metaM HC01603 c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
initial amount: NaN
is: C00234
initial concentration: 1.0
is: CHEBI:57454
boundary condition: false
name: 10-Formyltetrahydrofolate
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_445f196c_e70b_47d2_bd84_cb5750837dc1
name: CA8
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is: P35219
is encoded by: hsa:767

http://identifiers.org/biomodels.db/MODEL1310110021#_beef4e20_2059_4319_a8e4_a7c26f033739
is encoded by: hsa:219
type: Species
constant: false
is: P30837
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: ALDH1B1
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_bb014c47_da95_42ce_965a_a3fc4abe6f44
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
name: NME3
is encoded by: hsa:4832
is: SBO:0000252
is: Q13232
constant: false
has only substance units: false

metaR r1090
fast: false
is: SBO:0000185
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_bfd4b284_bf01_43ff_ad5d_7e88a01e885a
initial amount: NaN
is encoded by: hsa:30
is: Q96CA6
boundary condition: true
constant: false
has only substance units: false
type: Species
name: ACAA1
initial concentration: NaN
is: SBO:0000252

metaR UMPKn
product: MODEL1310110021#
modifier: MODEL1310110021#
name: UMP kinase, nuclear
is described by: ECO:0000269
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_fa9941c9_4e82_4aea_83bc_f0d1d8df2297
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:AV727634
name: _AV727634_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_d6a27c9a_96c9_4439_8be4_086092120324
has only substance units: false
constant: false
is encoded by: hsa:170712
boundary condition: true
is: SBO:0000252
name: COX7B2
is: Q8TF08
initial concentration: NaN
type: Species
initial amount: NaN

metaM tststerone e
is: HMDB00234
name: testosterone
is: SBO:0000247
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
initial amount: NaN
is: CHEBI:17347
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

metaM rbt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
has only substance units: false
type: Species
name: D-ribitol
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:15963
boundary condition: false
is: SBO:0000247
is: HMDB00508

metaR DESAT22 1p
type: Reaction
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reversible: false
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176

metaR r0424
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reversible: true
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.17.1.4

metaR FAOXC15ATPx
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C15)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_7a1f842c_37df_43f0_94fb_21e75d5d56e7
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q7L2M7
has only substance units: false
name: PFKL
type: Species
is encoded by: hsa:5211
boundary condition: true
initial amount: NaN

metaR r1573
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reversible: true
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_8d019e2d_3ee5_48b5_bef4_c2ccfd146a6a
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC28A1
is encoded by: hsa:9154
constant: false
type: Species
is: Q96PL7
has only substance units: false

metaR PROD2
reversible: false
fast: false
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000254
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
is: SBO:0000176
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.99.8
name: Proline dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110021#_6c6f5b45_5997_41d9_983b_debdbd7a3479
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: _AA629629_1_m
initial amount: NaN
is encoded by: hsa:AA629629
initial concentration: NaN
type: Species

metaM xoldioloneh c
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: CHEBI:2288
initial concentration: 1.0
is: HMDB06887
type: Species
has only substance units: false
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
constant: false

metaR r1646
is: SBO:0000185
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#

metaM ppcoa c
constant: false
type: Species
is: C00100
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
is: HMDB01275
boundary condition: false
is: CHEBI:57392

metaM leuktrA4 c
type: Species
constant: false
initial concentration: 1.0
is: HMDB01337
boundary condition: false
name: leukotriene A4(1-)
is: CHEBI:57463
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: SBO:0000247
has only substance units: false

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR COAtr
product: MODEL1310110021#
is: SBO:0000185
name: COA transporter, endoplasmic reticulum
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR RE1804M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110021#
name: RE1804
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true

metaR GLYBtm
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true

metaM xol27oh m
name: 26-hydroxycholesterol
type: Species
is: HMDB02103
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
has only substance units: false
boundary condition: false
is: CHEBI:17703

metaR r0423
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
is: SBO:0000176
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000000

metaR XOLTRIOLtm
name: lipid, flip-flop intracellular transport
product: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is: SBO:0000185

metaM HC01397 m
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
is: CHEBI:27402
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258

http://identifiers.org/biomodels.db/MODEL1310110021#_38d2b4cd_4bd2_45e8_9b3a_0318e764c297
is encoded by: hsa:51179
initial amount: NaN
type: Species
is: Q9NYQ3
initial concentration: NaN
has only substance units: false
name: HAO2
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d5e22b1a_278c_46ae_8534_e1aa2915d874
initial amount: NaN
is encoded by: hsa:AI653169
type: Species
initial concentration: NaN
has only substance units: false
name: _AI653169_1_c
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_39172745_60c2_49a4_8ff6_57bd47a141cd
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:5236
initial concentration: NaN
name: PGM1
is: B4DPV0

http://identifiers.org/biomodels.db/MODEL1310110021#_dca6c360_77f5_4f25_86c4_34b0d4f7631a
name: SLC25A15
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:10166
is: Q9Y619
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_c3350e58_a4fa_4a15_9b2a_c78d57df7277
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: PHYH
is: SBO:0000252
is encoded by: hsa:5264
constant: false
is: O14832

metaR C4STMO2Pr
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.170
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
name: C-4 methyl sterol oxidase
type: Reaction
modifier: MODEL1310110021#

metaM prpp e
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
constant: false
is: HMDB00280
initial concentration: 1.0
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: SBO:0000247
initial amount: NaN

metaR r1645
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
fast: false

metaR EX eaflatoxin LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 8,9 epxoy aflatoxin B1 exchange
type: Reaction

metaM ibcoa m
is: SBO:0000247
constant: false
is: CHEBI:57338
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
is: HMDB01243
boundary condition: false
name: isobutyryl-CoA(4-)

metaM for c
is: C00058
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: SBO:0000247
initial concentration: 1.0
name: Formate
is: CHEBI:15740
constant: false
is: HMDB00142
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_1d8188ec_6da7_4147_a717_8b709f85a5f8
initial concentration: NaN
name: _AL038231_1_c
initial amount: NaN
has only substance units: false
is encoded by: hsa:AL038231
boundary condition: true
type: Species
constant: false
is: SBO:0000252

metaM ahcys c
type: Species
initial amount: NaN
constant: false
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
is: CHEBI:16680
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00021
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_d601ae3f_52e1_4927_8e25_a3b3921066cc
boundary condition: true
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:BG035985
name: _BG035985_1_c
is: SBO:0000252

metaR GUAPRT
is described by: ECO:0000269
modifier: MODEL1310110021#
fast: false
name: guanine phosphoribosyltransferase
reversible: false
is: SBO:0000176
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT

metaM CE2420 m
is: HMDB11123
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: CHEBI:28387
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420

metaR r0426
fast: false
is: SBO:0000176
product: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.5.1.34
reversible: true
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3

metaM 5mthf e
constant: false
type: Species
initial concentration: 1.0
is: C00440
initial amount: NaN
is: CHEBI:3729
is: HMDB01396
is: SBO:0000247
name: 5-Methyltetrahydrofolate
notes: FORMULA: C20H24N7O6 CHARGE: -1
boundary condition: false
has only substance units: false

metaM hdcea r
constant: false
is: CHEBI:32372
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB03229
name: palmitoleate
initial amount: NaN
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
initial concentration: 1.0

metaM 7dhf e
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species
has only substance units: false
is: HMDB06559
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
name: heptaglutamyl folate (DHF)
is: SBO:0000247

metaR r0497
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
reactant: MODEL1310110021#

metaM cytd c
is: HMDB00089
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: Cytidine
boundary condition: false
is: C00475
is: CHEBI:17562
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_9deb01ec_ea1f_44f6_847a_1bbdb7d9cfe0
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1572
initial amount: NaN
name: CYP2F1
type: Species
is: P24903
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_ee2e387c_cca8_4ff4_8c45_d7adacfb071d
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI640625
constant: false
is: SBO:0000252
name: _AI640625_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_32a8d174_56c1_4694_806c_7a286e051c17
has only substance units: false
initial concentration: NaN
is: Q92604
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:9926
name: LPGAT1
constant: false

metaM tststerone r
initial concentration: 1.0
is: HMDB00234
name: testosterone
type: Species
boundary condition: false
constant: false
is: CHEBI:17347
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r1575
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110021#
is: SBO:0000185
reversible: true

metaR SQLSr
name: Squalene synthase
is: SBO:0000176
is described by: ECO:0000134
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.5.1.21
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ

metaR r1648
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185

metaR MAN6PI
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
name: mannose-6-phosphate isomerase
fast: false
reactant: MODEL1310110021#
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110021#
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/5.3.1.8

metaM cmpacna g
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
is: CHEBI:57812
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaM bamppald c
is: HMDB01106
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
name: beta-Aminopropion aldehyde
is: http://identifiers.org/pubchem.compound/7975
has only substance units: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: C05665
initial concentration: 1.0
boundary condition: false

metaM leuktrA4 e
is: HMDB01337
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: leukotriene A4(1-)
is: CHEBI:57463

metaM pail4p hs c
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial amount: NaN
is: CHEBI:58178
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

http://identifiers.org/biomodels.db/MODEL1310110021#_de6f1044_ed6f_4a46_82d5_364e772134e4
is encoded by: hsa:8372
boundary condition: true
constant: false
name: HYAL3
is: O43820
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_1187312f_f454_45ce_9c84_318c3058b435
constant: false
initial amount: NaN
is: O75106
is encoded by: hsa:314
name: AOC2
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

metaM tcynt e
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01453
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: CHEBI:18022
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: thiocyanate
type: Species

metaM crvnc e
constant: false
is: HMDB02183
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:36005
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C22H31O2 CHARGE: -1
name: cervonic acid, C22:6 n-3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_5d631c42_ffa5_4ee8_ac73_7a3a602e5c31
is encoded by: hsa:BE966236
has only substance units: false
type: Species
name: _BE966236_1_c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_21323712_48c0_4fd1_943f_09e71c1e33e8
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is: P28330
is encoded by: hsa:33
initial amount: NaN
constant: false
initial concentration: NaN
name: ACADL

metaM orot5p c
has only substance units: false
is: HMDB00218
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57538
is: SBO:0000247
type: Species
constant: false
name: Orotidine 5'-phosphate
is: C01103

metaR r1574
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction

metaR DEBRISOQUINEt
reversible: true
name: debrisoquine uniport
kinetic law: MODEL1310110021#
is described by: ECO:0000269
modifier: MODEL1310110021#
fast: false
product: MODEL1310110021#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6582.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ

metaR r1421
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reactant: MODEL1310110021#
is: SBO:0000185
fast: false
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
name: Free diffusion
is described by: ECO:0000000
reversible: true

metaR PGLer
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
is described by: ECO:0000269
name: 6-phosphogluconolactonase, endoplasmic reticulum
fast: false
modifier: MODEL1310110021#

metaR r1647
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000185
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_d27d9b01_0dc3_4808_b962_ff20650fce71
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:204
name: AK2
initial amount: NaN
is: P54819
type: Species

metaM abt c
is: CHEBI:18403
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
name: L-arabinitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN
is: HMDB01851
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_1b58ef27_99fb_4022_8541_d4569669e99d
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q6ZWP6
name: ACAD8
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:27034
has only substance units: false

metaM ps hs m
initial amount: NaN
constant: false
is: SBO:0000247
name: ps_hs[m]
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species
initial concentration: 1.0
is: CHEBI:18303
has only substance units: false

metaM ahcys e
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: CHEBI:16680
is: HMDB00939
name: S-Adenosyl-L-homocysteine
has only substance units: false
is: SBO:0000247
is: C00021
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_4d1a88c0_a3d6_4ccd_bb65_071424f3dde9
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P13686
is encoded by: hsa:54
type: Species
name: ACP5
has only substance units: false
constant: false

metaM CE4794 m
name: cis-6-dodecenoyl-CoA
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:57923
type: Species
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794

metaM for e
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
name: formate
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00142
is: CHEBI:15740
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_b18e4f39_b8c0_4de9_a03a_de691fb2a1b1
is encoded by: hsa:570
boundary condition: true
constant: false
type: Species
name: BAAT
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q14032

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

metaM 7dhf c
is: HMDB06559
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: heptaglutamyl folate (DHF)
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
boundary condition: false
has only substance units: false

metaM HC02204 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false
is: CHEBI:27624
initial concentration: 1.0
initial amount: NaN
name: prostaglandin-b1
is: SBO:0000247
type: Species
constant: false
boundary condition: false

metaM 5mthf c
constant: false
is: CHEBI:3729
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00440
is: HMDB01396
name: 5-Methyltetrahydrofolate
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_0123115e_cd67_4526_b5bd_fe67102c32d7
type: Species
name: TXNRD1
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:7296
has only substance units: false
initial amount: NaN
boundary condition: true

metaM dolp L r
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
name: dolichyl phosphate(2-)
initial concentration: 1.0

metaR COAtn
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: coenzyme A transport, nuclear
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reversible: true

metaR RE1898C
is: SBO:0000176
product: MODEL1310110021#
is described by: ECO:0000000
name: RE1898
kinetic law: MODEL1310110021#
fast: false
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_de68ea7e_76bb_4787_9082_c97ff650bf95
is: SBO:0000252
name: PIK3R5
is encoded by: hsa:23533
initial amount: NaN
is: Q8WYR1
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false

metaM leuktrB4 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: CHEBI:57461
initial amount: NaN
name: leukotriene B4(1-)
is: HMDB01085
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_299f63e0_e7be_4ccc_a1a6_8127522e1d11
has only substance units: false
is encoded by: hsa:3295
initial amount: NaN
initial concentration: NaN
constant: false
name: HSD17B4
boundary condition: true
is: E9PB82
type: Species
is: SBO:0000252

metaR PI45P3K
fast: false
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#

metaR r0339
modifier: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.22
reactant: MODEL1310110021#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
fast: false
reversible: false

metaM hxan c
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00157
is: CHEBI:17368
has only substance units: false
is: C00262
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: Hypoxanthine
type: Species
boundary condition: false

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_fc31e11e_1b64_4e80_a9dc_74bbdc69bdc7
has only substance units: false
constant: false
boundary condition: true
name: BCAT1
is encoded by: hsa:586
is: P54687
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_4082aab3_0a4d_4785_af2b_a819d9550a8d
has only substance units: false
type: Species
name: PRDX2
initial concentration: NaN
is encoded by: hsa:7001
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaM arg L e
name: L-argininium(1+)
type: Species
initial concentration: 1.0
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
constant: false
is: HMDB00517
initial amount: NaN
has only substance units: false
is: CHEBI:32682
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_9ca45f1a_3f3c_497a_ab25_813cb930d784
initial concentration: NaN
is encoded by: hsa:27306
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: O60760
name: HPGDS
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_ba95b407_9fa6_40cc_99ad_eebf3961b732
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: NME7
initial concentration: NaN
is: Q9Y5B8
is: SBO:0000252
type: Species
is encoded by: hsa:29922

metaR RE3004M
product: MODEL1310110021#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110021#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
modifier: MODEL1310110021#
name: RE3004

http://identifiers.org/biomodels.db/MODEL1310110021#_5390f1fb_0262_4b01_85bc_a0a89fd023a4
is encoded by: hsa:9167
initial amount: NaN
is: Q6FGA0
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
name: COX7A2L
is: SBO:0000252

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR r1649
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
fast: false
product: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110021#

metaR COAtm
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110021#
name: CoA transporter
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110021#

metaM sebcoa x
name: sebacoylcoa
constant: false
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_b102fb0c_65ca_4bba_8d16_5c537f13cdd7
initial amount: NaN
boundary condition: true
is: P51648
name: ALDH3A2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:224
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_82e184ed_2b56_4f5f_a951_dad0a2c5f9da
has only substance units: false
is encoded by: hsa:3612
is: B7Z6Q4
initial amount: NaN
is: SBO:0000252
name: IMPA1
type: Species
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_4471f2cf_c64b_4b91_9baf_467b10da3355
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8897
name: MTMR3
has only substance units: false

metaM tchola x
type: Species
name: taurocholate
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:36257
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00036

http://identifiers.org/biomodels.db/MODEL1310110021#_f5e34db2_9df4_43cc_9c72_882cea4630e8
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ACHE
constant: false
type: Species
is encoded by: hsa:43
has only substance units: false

metaM cala c
constant: false
initial amount: NaN
is: HMDB00026
type: Species
initial concentration: 1.0
is: CHEBI:11892
boundary condition: false
has only substance units: false
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
is: SBO:0000247
name: N-carbamoyl-beta-alaninate

http://identifiers.org/biomodels.db/MODEL1310110021#_5fa6d786_8296_4ba6_b50f_a522fb2f627c
is: P14854
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:1340
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: COX6B1

metaR FAEL183
modifier: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
type: Reaction
name: fatty-acyl-CoA elongation (n-C18:3CoA)
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is described by: ECO:0000000
fast: false
reversible: false

metaR RE2649C
modifier: MODEL1310110021#
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
reversible: true
is described by: ECO:0000000
name: RE2649
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110021#

metaR r1571
type: Reaction
fast: false
product: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RE2999M
product: MODEL1310110021#
reactant: MODEL1310110021#
name: RE2999
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110021#
type: Reaction
fast: false
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
is: SBO:0000176
reversible: true

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaM cholp c
initial concentration: 1.0
is: CHEBI:295975
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: choline phosphate(1-)

metaM CE5854 e
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB02710
name: gama-CEHC-glucuronide
has only substance units: false
initial amount: NaN
is: CHEBI:27485

metaM HC02204 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
has only substance units: false
is: CHEBI:27624
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
name: prostaglandin-b1
type: Species
boundary condition: false

metaM dttp n
is: HMDB01342
name: dTTP
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
is: CHEBI:37568
is: C00459
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_491f3bde_feab_4d69_9b42_d1d4ea3b2710
has only substance units: false
name: HSD17B10
is: Q99714
type: Species
initial amount: NaN
is encoded by: hsa:3028
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaR COAtp
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: coenzyme A transport, peroxisomal
product: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false

metaM hxan e
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: HMDB00157
is: CHEBI:17368
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
constant: false
name: hypoxanthine
initial amount: NaN

metaM leuktrB4 c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: leukotriene B4(1-)
is: HMDB01085
type: Species
constant: false
is: CHEBI:57461

http://identifiers.org/biomodels.db/MODEL1310110021#_1aba83ad_9fd6_4127_8778_704f005a87be
is encoded by: hsa:55512
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9NY59
boundary condition: true
name: SMPD3
constant: false

metaM arg L c
is: SBO:0000247
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
is: CHEBI:32682
boundary condition: false
has only substance units: false
initial amount: NaN
name: L-argininium(1+)
constant: false
is: HMDB00517

metaR r1570
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
type: Reaction
fast: false

metaR PIter
is described by: ECO:0000212
reactant: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110021#
name: phosphate transport, endoplasmic reticulum
modifier: MODEL1310110021#

metaM dcholcoa c
is: CHEBI:28701
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
constant: false
type: Species

metaM arachdcoa r
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
boundary condition: false
is: CHEBI:57368
constant: false
type: Species
initial amount: NaN
name: arachidonoyl-CoA(4-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_acf979fe_543b_41bb_be91_6651d3339da3
is: Q92903
name: CDS1
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:1040
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM L2aadp m
is: SBO:0000247
is: HMDB00510
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
type: Species
boundary condition: false
constant: false
is: CHEBI:58672
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: L-2-aminoadipate(1-)

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR r0494
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110021#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110021#
fast: false
product: MODEL1310110021#

metaR FAOXC225m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaM CE1936 e
initial amount: NaN
is: CHEBI:36781
has only substance units: false
boundary condition: false
name: spermine dialdehyde
type: Species
constant: false
notes: FORMULA: C10H22N2O2 CHARGE: 2 INCHI: InChI=1/C10H20N2O2/c13-9-3-7-11-5-1-2-6-12-8-4-10-14/h9-12H,1-8H2/p+2 EHMN_ABBREVIATION: CE1936
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_38d5af9d_6c05_4d3d_b37f_741fab8fb78d
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: Q96AT9
constant: false
is encoded by: hsa:6120
name: RPE
has only substance units: false

metaR ABUTD
name: Aminobutyraldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_d9a608c6_8bda_4c30_aa47_56fc6b6ecb91
is encoded by: hsa:AA854479
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AA854479_1_m
boundary condition: true
has only substance units: false
constant: false

metaM prpp c
initial amount: NaN
is: C00119
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
is: HMDB00280
has only substance units: false
boundary condition: false

metaM n2m2nmn l
constant: false
is: HMDB00939
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: CHEBI:16680
type: Species
boundary condition: false
notes: FORMULA: C50H84N4O36 CHARGE: 0

metaR ADK3
product: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
type: Reaction
name: adentylate kinase (GTP)
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
kinetic law: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR

metaR FAOXC122m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR DHCRD2
is: SBO:0000176
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
name: dihydroceramide desaturase
product: MODEL1310110021#
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110021#
fast: false
reactant: MODEL1310110021#

metaR H2Oter
fast: false
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_1b61a966_acea_49a5_89d5_9c7c0a1bf48f
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:4594
is: SBO:0000252
is: P22033
boundary condition: true
constant: false
name: MUT
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_12b742f6_ef94_4064_9aad_75a87e0a66c3
is encoded by: hsa:2678
initial concentration: NaN
name: GGT1
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaM amp r
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
constant: false
is: C00020
initial concentration: 1.0
is: CHEBI:456215
boundary condition: false
name: AMP
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r0641
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4
reversible: true
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

metaR RE3326M
reversible: true
fast: false
is: SBO:0000176
name: RE3326
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_36c2446d_eca5_4329_b328_98754192f12d
initial amount: NaN
is: SBO:0000252
name: ACAD9
constant: false
is encoded by: hsa:28976
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: Q9H845

metaR r2310
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction

metaR RE3421R
fast: false
reactant: MODEL1310110021#
is: SBO:0000176
kinetic law: MODEL1310110021#
reversible: true
name: RE3421
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_69c20df8_a05e_4482_aa9b_8a2332cd4a31
has only substance units: false
is encoded by: hsa:6240
is: SBO:0000252
initial amount: NaN
constant: false
is: P23921
name: RRM1
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_7d2becd9_f050_4bfc_aaf0_a575a891d66b
is: SBO:0000252
type: Species
is encoded by: hsa:8801
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: SUCLG2
is: Q96I99
boundary condition: true

metaR CHOLD2m
is version of: http://identifiers.org/ec-code/1.1.99.1
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
modifier: MODEL1310110021#
fast: false
type: Reaction
kinetic law: MODEL1310110021#
reversible: false
name: choline dehydrogenase (FAD acceptor), mitochondrial

metaR D3AIBTm
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110021#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM

metaR r0960
reversible: true
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1

http://identifiers.org/biomodels.db/MODEL1310110021#_3832d2c0_dd32_4ab0_884f_15a1052fe372
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2592
type: Species
is: SBO:0000252
name: GALT
is: B2RAT6
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_deff0f61_8a87_41cb_bb35_d7b75de563ea
constant: false
is: SBO:0000252
is: Q9BW60
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: ELOVL1
initial amount: NaN
is encoded by: hsa:64834

http://identifiers.org/biomodels.db/MODEL1310110021#_e7412ded_f79d_441c_bf7a_58a1cecea174
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6342
boundary condition: true
is: C9JC79
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SCP2

http://identifiers.org/biomodels.db/MODEL1310110021#_cc222823_d070_4676_b670_745d2ec6dc93
name: SLCO4A1
boundary condition: true
has only substance units: false
is: Q96BD0
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:28231

metaR RE1520M
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110021#
type: Reaction
fast: false
modifier: MODEL1310110021#
name: RE1520
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
reactant: MODEL1310110021#
is: SBO:0000176

metaR MEVK1x
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
fast: false
is: SBO:0000176
kinetic law: MODEL1310110021#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.1.36
product: MODEL1310110021#
name: mevalonate kinase (atp)
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: false
type: Reaction

metaM Lkynr c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00684
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16946
name: L-kynurenine
type: Species

metaR r1428
name: Free diffusion
reactant: MODEL1310110021#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
fast: false

metaR RE2659R
product: MODEL1310110021#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
is described by: ECO:0000000
name: RE2659
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false

metaM crm hs g
is: SBO:0000247
initial amount: NaN
is: CHEBI:52639
has only substance units: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
initial concentration: 1.0
type: Species
boundary condition: false
constant: false

metaR r2311
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is: SBO:0000185

metaR r0642
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_1e833978_f85e_4360_a386_13a0fb1953e7
is: SBO:0000252
is: E9PB82
name: HSD17B4
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:3295

metaR P4502A6
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1553.1) or (1548.1) SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:9827545 NOTES:coumarin: 7 hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
is version of: http://identifiers.org/ec-code/1.14.14.1
reversible: false
is: SBO:0000176
modifier: MODEL1310110021#
reactant: MODEL1310110021#
name: cytochrome P450 2A6

metaM xtsn c
type: Species
name: xanthosine
has only substance units: false
initial amount: NaN
is: CHEBI:18107
is: HMDB00299
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762

http://identifiers.org/biomodels.db/MODEL1310110021#_0db5b7b9_8135_4461_b66f_821a0554a705
type: Species
initial concentration: NaN
is encoded by: hsa:8836
has only substance units: false
constant: false
is: Q92820
initial amount: NaN
name: GGH
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_5cfe91fc_c282_456d_bc59_af05322b73ba
is encoded by: hsa:9123
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: O15427
name: SLC16A3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_0a85f622_3419_4908_b065_260bc5432076
is encoded by: hsa:51251
has only substance units: false
is: Q9H0P0
boundary condition: true
is: SBO:0000252
name: NT5C3
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

metaR RE3242R
fast: false
reversible: true
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
name: RE3242
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110021#

metaR r1914
modifier: MODEL1310110021#
reversible: false
name: Y+LAT2 Utilized transport
product: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110021#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110021#

metaM gchola c
is: HMDB00138
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:58235
name: glycocholate
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921

http://identifiers.org/biomodels.db/MODEL1310110021#_9fe64033_c005_454f_a739_a4e0f275a382
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _H77542_1_r
is encoded by: hsa:H77542
constant: false
type: Species
boundary condition: true
has only substance units: false

metaR CERT2gt
fast: false
is: SBO:0000185
reactant: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110021#
name: ceramide transport protein
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside

metaR ME1m
is described by: ECO:0000000
name: malic enzyme (NAD), mitochondrial
is: SBO:0000176
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.38
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110021#
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#

metaR ADK1
name: adenylate kinase
fast: false
is described by: ECO:0000269
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3

http://identifiers.org/biomodels.db/MODEL1310110021#_fd24076c_c0f1_4e5e_96ed_595bbac07ea1
is encoded by: hsa:4514
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
is: P00414
has only substance units: false
name: COX3

metaM fru c
initial concentration: 1.0
is: C00095
type: Species
is: SBO:0000247
is: CHEBI:15824
boundary condition: false
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
constant: false
is: HMDB00660
name: D-Fructose
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_553b2cb2_694b_4acb_91a0_f626eb70b471
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:284129
name: SLC26A11
is: SBO:0000252
constant: false
type: Species
is: Q86WA9

http://identifiers.org/biomodels.db/MODEL1310110021#_f480b60b_ce13_419c_9755_43814db119da
name: GART
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
is: P22102
is encoded by: hsa:2618
boundary condition: true

metaR RE3074X
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
fast: false
product: MODEL1310110021#
name: RE3074
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_c01b21e7_ea85_4875_b67d_82ee9c016575
name: _AI091231_1_c
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI091231
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaM hxcoa m
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB06522
is: SBO:0000247
boundary condition: false
name: Hexanoyl-CoA (n-C6:0CoA)
initial amount: NaN

metaR r1429
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110021#
type: Reaction
name: Free diffusion
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_a93644e3_96ca_4693_9cd1_036e2987c497
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: ACSL3
constant: false
is: B3KMA6
is encoded by: hsa:2181
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_5d2d0997_f71a_49c1_a632_5eba09f51377
boundary condition: true
name: NT5C2
is encoded by: hsa:22978
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: P49902
initial concentration: NaN

metaR r1913
fast: false
product: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110021#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_3cb3563a_711b_466c_89e0_2f1963cba2ef
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: P05091
boundary condition: true
name: ALDH2
constant: false
is encoded by: hsa:217

metaM dopa c
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: SBO:0000247
type: Species
is: CHEBI:59905
name: dopaminium(1+)
is: HMDB00073
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_849f301c_2930_48f2_8763_37d7872582ba
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1375
is: E9PCP2
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: CPT1B

metaR r0962
type: Reaction
reversible: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Facilitated diffusion

metaR ACITL
name: ATP-Citrate lyase
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
type: Reaction
reversible: false
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.3.3.8
fast: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000

metaM CE2433 m
type: Species
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
is: CHEBI:57795
is: SBO:0000247
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_c32e269e_d567_4248_a02f_00d9b0125e93
initial amount: NaN
type: Species
initial concentration: NaN
is: E7ET30
is encoded by: hsa:50808
is: SBO:0000252
has only substance units: false
name: AK3
boundary condition: true
constant: false

metaM mi1p D c
is: CHEBI:58433
constant: false
initial amount: NaN
boundary condition: false
name: 1D-myo-inositol 1-phosphate(2-)
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB02985
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698

http://identifiers.org/biomodels.db/MODEL1310110021#_6ccd94ef_f138_475f_8cf6_0195ea88483c
is: P05062
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:229
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ALDOB
is: SBO:0000252

metaR r2313
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r1995
reactant: MODEL1310110021#
fast: false
modifier: MODEL1310110021#
type: Reaction
is: SBO:0000185
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM prostgf2 e
name: prostaglandin F2alpha(1-)
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: HMDB01139
constant: false
is: CHEBI:57404
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaM cholp g
type: Species
name: choline phosphate(1-)
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C00588
is: CHEBI:295975
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial amount: NaN

metaR r0644
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
fast: false
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
type: Reaction
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_d3828ed8_2c21_4cb7_8d58_79a23689528f
is: SBO:0000252
boundary condition: true
name: ACADS
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:35
has only substance units: false
is: P16219
initial concentration: NaN

metaM 5aizc c
is: C04751
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
type: Species
constant: false
is: HMDB06273
boundary condition: false
is: SBO:0000247
is: CHEBI:58564
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM glcur r
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
boundary condition: false
has only substance units: false
is: HMDB00127
name: D-glucuronate
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_80998a4a_5d37_47ed_b925_7585268d4f0d
name: SLC26A6
has only substance units: false
is: Q9Y3Y1
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:65010
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r1640
reactant: MODEL1310110021#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110021#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110021#

metaM s7p c
is: SBO:0000247
type: Species
name: Sedoheptulose 7-phosphate
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: CHEBI:57483
initial concentration: 1.0
is: C05382
constant: false
is: HMDB01068
initial amount: NaN
has only substance units: false
boundary condition: false

metaM itp n
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: HMDB00189
is: CHEBI:57614
name: ITP(3-)
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaM glcur l
constant: false
initial amount: NaN
has only substance units: false
name: D-glucuronate
is: CHEBI:15748
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c0af60e9_301e_44ad_9282_d8eb966a70fb
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:100287639
initial amount: NaN
name: _100287639_1_c
constant: false
has only substance units: false
type: Species

metaR CATm
notes: GENE_ASSOCIATION: (847.1) SUBSYSTEM: ROS detoxification EC Number: 1.11.1.6 Confidence Level: 4 AUTHORS: PMID:1657986,PMID:3755525 NOTES:TV
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.11.1.6
is: SBO:0000176
modifier: MODEL1310110021#
reactant: MODEL1310110021#
name: catalase
product: MODEL1310110021#
type: Reaction
fast: false
kinetic law: MODEL1310110021#

metaM malthp e
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
boundary condition: false
is: http://identifiers.org/pubchem.compound/5041
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: maltoheptaose
initial concentration: 1.0
is: C01936

http://identifiers.org/biomodels.db/MODEL1310110021#_bb7c99d4_2546_4867_b43d_7cf6aa9605fe
constant: false
has only substance units: false
is encoded by: hsa:3418
is: SBO:0000252
is: P48735
initial concentration: NaN
name: IDH2
boundary condition: true
initial amount: NaN
type: Species

metaM fru e
is: C00095
is: CHEBI:15824
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
initial amount: NaN
name: D-Fructose
type: Species

metaR r1641
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110021#
type: Reaction
reversible: true
reactant: MODEL1310110021#

metaR EX c4crn
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaM arachdcoa x
is: HMDB06523
has only substance units: false
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

metaM frdp r
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: C00448
type: Species
has only substance units: false
constant: false
name: Farnesyl diphosphate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:175763
boundary condition: false
is: HMDB00961
is: SBO:0000247

metaM bilglcur e
has only substance units: false
is: CHEBI:57767
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
is: SBO:0000247
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR PUNP6
product: MODEL1310110021#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
is: SBO:0000176
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Deoxyinosine)
modifier: MODEL1310110021#
type: Reaction

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR RE0452M
is described by: ECO:0000000
name: RE0452
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
reversible: true
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_2a96ce18_bd76_4520_98e4_a06f01e82dc9
constant: false
initial amount: NaN
name: RPIA
initial concentration: NaN
type: Species
is encoded by: hsa:22934
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P49247

metaR r0909
fast: false
kinetic law: MODEL1310110021#
reversible: true
type: Reaction
product: MODEL1310110021#
is described by: ECO:0000000
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is: SBO:0000185
reactant: MODEL1310110021#

metaM amp m
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
is: HMDB00045
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:456215
has only substance units: false
name: AMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110021#_d9efd446_fcc8_4795_9c34_2c1cd1cb087b
boundary condition: true
is: Q546Y9
initial concentration: NaN
type: Species
is encoded by: hsa:57379
name: AICDA
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaM glu L e
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:29985
boundary condition: false
is: HMDB00148
type: Species
name: L-glutamate(1-)

http://identifiers.org/biomodels.db/MODEL1310110021#_c69e277c_c16a_47f8_8f26_5d56422605b1
is encoded by: hsa:84812
has only substance units: false
initial amount: NaN
is: Q9BRC7
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
name: PLCD4

metaM dttp c
constant: false
is: C00459
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
type: Species
is: HMDB01342
has only substance units: false
name: dTTP
is: SBO:0000247
is: CHEBI:37568
initial concentration: 1.0
initial amount: NaN

metaR ALAGLYexR
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
reactant: MODEL1310110021#
modifier: MODEL1310110021#
name: L-alanine/glycine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110021#_086ecdee_75ac_45b5_b417_fa8c5952203b
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:3155
has only substance units: false
name: HMGCL
initial concentration: NaN
is: Q6IBC0
boundary condition: true
initial amount: NaN

metaR r1642
reactant: MODEL1310110021#
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110021#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000

metaR LEUGLYHYc
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110021#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: hydrolysis of leucylglycine

metaM ppcoa x
boundary condition: false
initial amount: NaN
is: C00100
name: Propanoyl-CoA
has only substance units: false
constant: false
is: HMDB01275
initial concentration: 1.0
type: Species
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_c561335a_a4dc_48af_aa52_05bb7cf52c2b
is encoded by: hsa:230
boundary condition: true
initial amount: NaN
is: P09972
initial concentration: NaN
type: Species
has only substance units: false
constant: false
name: ALDOC
is: SBO:0000252

metaR r0331
kinetic law: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
reversible: false
modifier: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reactant: MODEL1310110021#

metaR PUNP5
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
name: purine-nucleoside phosphorylase (Inosine)
product: MODEL1310110021#
is described by: ECO:0000269
reactant: MODEL1310110021#

metaR EX debrisoquine LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: debrisoquine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_257204c7_4945_4c54_a4a2_8a691ce9f803
has only substance units: false
name: PGM2
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: Q96G03
is encoded by: hsa:55276
is: SBO:0000252
constant: false

metaM dnad c
name: Deamino-NAD+
boundary condition: false
is: C00857
initial concentration: 1.0
constant: false
is: CHEBI:18304
initial amount: NaN
is: HMDB01179
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_454c3e0d_ae1e_47b7_8938_c2de56a2b2af
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _AF080579_1_c
is encoded by: hsa:AF080579

http://identifiers.org/biomodels.db/MODEL1310110021#_29e7027d_92be_46db_9ca7_be96c6756b5a
type: Species
has only substance units: false
is: P31639
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6524
name: SLC5A2
initial amount: NaN
constant: false
boundary condition: true

metaM prostgf2 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247
initial amount: NaN
is: HMDB01139
initial concentration: 1.0
has only substance units: false
is: CHEBI:57404
boundary condition: false
constant: false
name: prostaglandin F2alpha(1-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_68d2cacb_e7ef_4f09_a749_06796177c277
boundary condition: true
is: Q14376
constant: false
is encoded by: hsa:2582
has only substance units: false
initial concentration: NaN
name: GALE
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_7914fa92_cfb7_463b_861f_d2afe9fdd087
is: SBO:0000252
type: Species
name: AMPD2
is encoded by: hsa:271
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: B2RB47
initial concentration: NaN

metaR r0908
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#
is described by: ECO:0000000
fast: false
product: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
type: Reaction
name: Postulated transport reaction

metaR NDPK10
kinetic law: MODEL1310110021#
is described by: ECO:0000134
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: true
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dIDP)
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false

metaR GLUDxm
reversible: true
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.4.1.3
product: MODEL1310110021#
fast: false
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
name: glutamate dehydrogenase (NAD) (mitochondrial)
modifier: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_715b7801_3dff_4256_bfca_bbe0cb81bae2
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA278423
name: _AA278423_1_c

http://identifiers.org/biomodels.db/MODEL1310110021#_8ba705a9_4876_4710_a381_0242d21fdd43
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: _7359_1_c
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7359
boundary condition: true

metaM lthstrl r
initial concentration: 1.0
constant: false
is: HMDB01170
is: CHEBI:17168
boundary condition: false
is: SBO:0000247
type: Species
name: 5alpha-cholest-7-en-3beta-ol
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_69ab053c_d39c_4d6e_9637_bb08a81527de
is: SBO:0000252
initial amount: NaN
name: NIT2
type: Species
constant: false
is: Q9NQR4
has only substance units: false
is encoded by: hsa:56954
initial concentration: NaN
boundary condition: true

metaM nadh c
initial concentration: 1.0
is: HMDB01487
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: C00004
initial amount: NaN
has only substance units: false
boundary condition: false

metaR BETALDHxm
name: betaine-aldehyde dehydrogenase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110021#
fast: false
reversible: false
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM

metaM mlthf m
boundary condition: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
name: 5,10-Methylenetetrahydrofolate
constant: false
type: Species
initial amount: NaN
is: CHEBI:15636
has only substance units: false
is: SBO:0000247
is: HMDB01533
initial concentration: 1.0

metaR r1643
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110021#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110021#

metaR ATP2ter
type: Reaction
name: AMP/ATP transporter, endoplasmic reticulum
reversible: true
kinetic law: MODEL1310110021#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110021#
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_3dfeb6d8_5522_439d_968e_911adac7c247
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: NDUFS2
initial concentration: NaN
initial amount: NaN
is: B7Z792
is encoded by: hsa:4720
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_2f25a142_59d8_4b47_9073_eabd13e866ac
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:100128062
name: _100128062_1_m
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110021#_2f25a1af_eb69_4682_8f38_6162ea33f51c
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P11166
constant: false
name: SLC2A1
boundary condition: true
is encoded by: hsa:6513

http://identifiers.org/biomodels.db/MODEL1310110021#_5d96fb09_796e_4ffc_99a2_6eb45efd6fe4
is: Q6IBC4
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:4726
is: SBO:0000252
initial concentration: NaN
name: NDUFS6
initial amount: NaN

metaR r2047
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reversible: false
fast: false
modifier: MODEL1310110021#
is described by: ECO:0000000
type: Reaction

metaM CE5121 m
initial concentration: 1.0
is: CHEBI:57449
type: Species
is: SBO:0000247
constant: false
name: trans-3-decenoyl-CoA
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false
boundary condition: false
initial amount: NaN

metaR HSD17B9r
name: 17-beta-hydroxysteroid dehydrogenase (type 7)
product: MODEL1310110021#
reactant: MODEL1310110021#
modifier: MODEL1310110021#
is described by: ECO:0000304
reversible: false
kinetic law: MODEL1310110021#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51478.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES:see PMID: 14643063 inferred use of O2 for oxidation - biochemical details have not yet been experimentally elucidated NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.62

metaR r0647
reversible: true
name: Spontaneous reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110021#_a708bf50_ddc0_4bc2_a8d9_55c0d92f4b5a
is encoded by: hsa:6901
initial amount: NaN
name: TAZ
is: Q16635
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_05a528e4_e4d4_483d_8a84_c0eba5dfa3ef
is: O95436
name: SLC34A2
is: SBO:0000252
is encoded by: hsa:10568
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

metaR ANTHte
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110021#
is described by: ECO:0000134
fast: false
reversible: true
name: Transport of anthranilate

http://identifiers.org/biomodels.db/MODEL1310110021#_d23305da_c5ee_4450_a381_2229ca16e74e
type: Species
is: SBO:0000252
is encoded by: hsa:9651
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O75038
name: PLCH2

metaR LYStip
fast: false
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000185
name: L-lysine transport, peroxisomal (irreversible)

metaM glu L c
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: L-glutamate(1-)
is: CHEBI:29985
type: Species
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: HMDB00148

metaM dttp e
is: HMDB01342
has only substance units: false
is: CHEBI:37568
constant: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP(4-)
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_5a3e74bc_c28e_402a_88f3_6ad3f7b52823
constant: false
is encoded by: hsa:W87865
is: SBO:0000252
type: Species
name: _W87865_1_c
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR 3HBCOAHLm
kinetic law: MODEL1310110021#
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reactant: MODEL1310110021#

metaR r1991
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110021#
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
modifier: MODEL1310110021#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR UAGALDP
kinetic law: MODEL1310110021#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: UDP-N-acetylgalactosamine diphosphorylase
is: SBO:0000176

metaM L2aadp c
name: L-2-aminoadipate(1-)
initial concentration: 1.0
is: HMDB00510
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:58672
initial amount: NaN
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaR r1644
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110021#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110021#

metaR FPGS4m
name: folylpolyglutamate synthetase (DHF), mitochondrial
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.2.17
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110021#_4ffb6d21_3e44_4d39_9450_6bbb5a2b22e9
initial amount: NaN
type: Species
has only substance units: false
is: Q99643
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6391
initial concentration: NaN
name: SDHC
constant: false

metaR NH4t3r
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110021#
is described by: ECO:0000269
modifier: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
name: ammonia transport via proton antiport
type: Reaction
product: MODEL1310110021#

metaR EX meoh LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: methanol exchange
type: Reaction

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: SBO:0000247
is: CHEBI:15991
name: Ferricytochrome c
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false

metaM thym c
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:17821
constant: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
boundary condition: false
initial concentration: 1.0
name: Thymine
is: HMDB00262
is: C00178
has only substance units: false

metaM ile L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
has only substance units: false
initial amount: NaN
type: Species
name: L-isoleucine
is: CHEBI:17191
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00172
constant: false

metaM dece3coa m
name: 3-decenoylcoa
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM gchola e
has only substance units: false
constant: false
name: glycocholate
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0
is: HMDB00138

metaM fgam c
is: C04376
constant: false
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01308
type: Species
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
initial amount: NaN
is: CHEBI:58426

metaR PUNP7
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Xanthosine)
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction

metaR NDPK8n
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
product: MODEL1310110021#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
reactant: MODEL1310110021#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear

http://identifiers.org/biomodels.db/MODEL1310110021#_a4956d93_003a_455f_a786_13405c0ca0a1
has only substance units: false
name: MGLL
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:11343
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q99685

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR PUNP2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
product: MODEL1310110021#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_b085e751_d917_4310_8830_0436346a9fe2
is encoded by: hsa:5295
name: PIK3CA:PIK3R1
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
has part: P27986
has only substance units: false
boundary condition: true
is: SBO:0000297

metaR r0754
kinetic law: MODEL1310110021#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
product: MODEL1310110021#

metaR DURAD2
reversible: true
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.2
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
modifier: MODEL1310110021#
name: dihydrothymin dehydrogenase (NADP)
is described by: ECO:0000269
fast: false

metaM 2mb2coa m
constant: false
name: 2-methylcrotonoyl-CoA(4-)
is: CHEBI:57337
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB02054
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_6d8068f6_3f08_4cb0_a972_dedac296c864
boundary condition: true
name: NDUFB5
is: O43674
is: SBO:0000252
type: Species
is encoded by: hsa:4711
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM 5mta c
is: HMDB01173
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
initial concentration: 1.0
is: CHEBI:17509
constant: false
type: Species
name: 5-Methylthioadenosine
is: C00170
initial amount: NaN

metaR LEUKTRE4t
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110021#
fast: false
name: leukotriene E4 transport
product: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#

metaM imp c
initial concentration: 1.0
has only substance units: false
is: C00130
is: CHEBI:58053
is: HMDB00175
boundary condition: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
name: IMP
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaM guln r
name: L-gulonate
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:13115
constant: false
is: HMDB03290
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800

metaR HSD17B4x
product: MODEL1310110021#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
name: hydroxysteroid (17-beta) dehydrogenase 4
reversible: false
modifier: MODEL1310110021#
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110021#

metaR r2318
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM CE5160 r
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: 3-oxo-cis-9-octadecenoyl-CoA
is: SBO:0000247
is: CHEBI:57923
initial concentration: 1.0
boundary condition: false

metaM tststerone c
initial amount: NaN
type: Species
constant: false
is: HMDB00234
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17347
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_72d222b3_a1dd_40f6_bed1_c548ba17b801
boundary condition: true
name: FOLR1
constant: false
initial amount: NaN
is encoded by: hsa:2348
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaM CE5118 m
is: CHEBI:57923
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
has only substance units: false
constant: false
initial amount: NaN
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
type: Species

metaR PUNP1
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
reactant: MODEL1310110021#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
fast: false
name: purine-nucleoside phosphorylase (Adenosine)
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_38140e4a_6469_4178_8213_ea9db48110aa
constant: false
is encoded by: hsa:8883
boundary condition: true
is: A8MU28
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
name: NAE1

metaR ILEt4
is: SBO:0000185
reactant: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
name: L-isoleucine transport in via sodium symport
kinetic law: MODEL1310110021#
reversible: false
type: Reaction
modifier: MODEL1310110021#

metaR r0755
modifier: MODEL1310110021#
reversible: true
product: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:

metaM ile L e
type: Species
has only substance units: false
is: HMDB00172
is: CHEBI:17191
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
is: SBO:0000247
name: L-isoleucine
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_72b56929_e686_479a_bc24_66e636ac9061
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: Q53HE2
is: SBO:0000252
is encoded by: hsa:7167
boundary condition: true
name: TPI1

metaM for r
type: Species
is: CHEBI:15740
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: HMDB00142
boundary condition: false
initial amount: NaN
constant: false
name: Formate
is: C00058
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_8ff78359_a8e3_468f_8a67_508ea7475dc1
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:1103
is: SBO:0000252
name: CHAT
boundary condition: true
is: Q6LEN5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_29d10ea2_2e5f_40ac_aaad_08cbae149617
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:51109
name: RDH11
is: B4DDW0
constant: false
initial concentration: NaN
is: SBO:0000252

metaR RE3524R
kinetic law: MODEL1310110021#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
name: RE3524

http://identifiers.org/biomodels.db/MODEL1310110021#_00a4b023_1628_4e34_b44b_976263bed8d1
constant: false
is: P08236
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:2990
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GUSB

http://identifiers.org/biomodels.db/MODEL1310110021#_cb61f424_f256_4e69_a25b_777ed749e8b4
initial concentration: NaN
is encoded by: hsa:11182
constant: false
has only substance units: false
name: SLC2A6
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9UGQ3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_894f900d_d10d_4aab_8922_f566235100a4
is encoded by: hsa:91703
boundary condition: true
name: ACY3
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: Q96HD9

http://identifiers.org/biomodels.db/MODEL1310110021#_7f8270c6_603a_4857_99c7_d861f8486797
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _206_1_c
is encoded by: hsa:206

metaM 3hexdtricoa m
name: 3,7,10-hexadecatrienoylcoa
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
type: Species
has only substance units: false
initial amount: NaN

metaM cholcoads x
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:27505
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
type: Species
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
is: HMDB06889
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_9ad129b5_1bbf_42bd_b85d_e05be2c46b39
initial amount: NaN
is encoded by: hsa:34
is: P11310
is: SBO:0000252
name: ACADM
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_896fcdd7_0941_4f5e_b730_5a3bf93a32fc
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:5728
initial amount: NaN
is: SBO:0000252
is: F6KD01
boundary condition: true
name: PTEN

metaR B3GALT5g
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110021#
type: Reaction
name: Beta-1,3-galactosyltransferase 5
modifier: MODEL1310110021#
reversible: false
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_7e59123a_c4d2_4040_92fd_453c03dcdf3a
initial amount: NaN
has only substance units: false
is encoded by: hsa:275
is encoded by: hsa:2653
boundary condition: true
has part: P23378
type: Species
initial concentration: NaN
has part: P48728
constant: false
has part: P23434
is encoded by: hsa:1738
has part: P09622
is encoded by: hsa:2731
name: DLD:GCSH:GLDC:AMT
is: SBO:0000297

metaM dmhptcrn m
initial amount: NaN
is: SBO:0000247
constant: false
name: 2,6 dimethylheptanoyl carnitine
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB06320
type: Species

metaR r2319
type: Reaction
is described by: ECO:0000000
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110021#_a36dd64e_d0df_4b24_af80_dc421ea05ffd
is encoded by: hsa:6569
constant: false
is: Q7Z725
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: SLC34A1
boundary condition: true

metaR ALAGLNexR
is described by: ECO:0000304
product: MODEL1310110021#
reactant: MODEL1310110021#
name: L-alanine/glutamine reversible exchange
is: SBO:0000185
kinetic law: MODEL1310110021#
reversible: true
modifier: MODEL1310110021#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110021#_44675bef_ddec_4508_a887_518834e65ba2
is: Q16134
initial amount: NaN
constant: false
is encoded by: hsa:2110
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ETFDH

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaM frdp x
is: CHEBI:175763
is: SBO:0000247
type: Species
is: HMDB00961
initial amount: NaN
constant: false
name: farnesyl pyrophosphate(3-)
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaM bilglcur c
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57767
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f995fcec_4369_4a39_9051_0d8174c95c57
is: O14521
name: SDHD
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:6392
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR PUNP4
is: SBO:0000176
reactant: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110021#
is described by: ECO:0000269
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
name: purine-nucleoside phosphorylase (Deoxyguanosine)
type: Reaction
kinetic law: MODEL1310110021#

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaM xol7aone r
is: CHEBI:17899
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01993
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
type: Species
boundary condition: false
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one

http://identifiers.org/biomodels.db/MODEL1310110021#_2ee322c1_f493_4d49_9273_9317d188dfaa
is encoded by: hsa:157506
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: RDH10
is: SBO:0000252
is: Q8IZV5
type: Species
has only substance units: false

metaM 5mta e
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17509
initial concentration: 1.0
type: Species
is: C00170
initial amount: NaN
name: 5-Methylthioadenosine
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: HMDB01173

metaR NTD2e
reactant: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
name: 5'-nucleotidase (UMP), extracellular
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000134

metaR LTD4DP
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
reversible: true
reactant: MODEL1310110021#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110021#
product: MODEL1310110021#
name: Leukotriene D4 dipeptidase
type: Reaction

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110021#_2d129f7a_ef38_4b3b_b110_26120fe05290
is encoded by: hsa:AI915649
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: _AI915649_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_d5f43ce3_8652_4d38_8681_78d56c674293
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:55350
name: VNN3
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species

metaR SUCOASm
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
is version of: http://identifiers.org/ec-code/6.2.1.5
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110021#
is described by: ECO:0000000
name: Succinate--CoA ligase (ADP-forming)
reversible: true
reactant: MODEL1310110021#

metaM HC01231 m
initial amount: NaN
type: Species
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
has only substance units: false
is: CHEBI:58480

metaR METyLATthc
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM dcholcoa x
boundary condition: false
initial amount: NaN
is: CHEBI:28701
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110021#_438f759a_a9e2_44fe_bbd4_5506d779dcf9
boundary condition: true
name: GMPPB
constant: false
is encoded by: hsa:29925
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: Q9Y5P6
is: SBO:0000252

metaM c14dccoa x
initial amount: NaN
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
is: SBO:0000247
boundary condition: false
is: HMDB02288
has only substance units: false
name: tetradecanedioylcoa
initial concentration: 1.0
type: Species
constant: false

metaR r0531
fast: false
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
reversible: true
modifier: MODEL1310110021#
is: SBO:0000176
reactant: MODEL1310110021#

metaR r2200
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
fast: false
product: MODEL1310110021#
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110021#

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaM crm hs r
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
has only substance units: false
initial concentration: 1.0
name: N-acylsphingosine

metaR CITt4 4
name: citrate transport via sodium symport
fast: false
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
reversible: true
is: SBO:0000185
reactant: MODEL1310110021#
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is described by: ECO:0000006
type: Reaction

metaR PUNP3
product: MODEL1310110021#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
is: SBO:0000176
name: purine-nucleoside phosphorylase (Guanosine)
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#

metaM air c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
is: CHEBI:58592
constant: false
has only substance units: false
type: Species
is: C03373
is: HMDB01235
boundary condition: false

metaM glyc S c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: 0
has only substance units: false
type: Species
is: CHEBI:33871
is: HMDB06372
name: (S)-Glycerate

metaR RE3567C
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#
reversible: true
product: MODEL1310110021#
name: RE3567
type: Reaction
fast: false

metaR LYSOXp
product: MODEL1310110021#
reactant: MODEL1310110021#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
name: L-lysine oxidase, peroxisomal
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110021#_70bd8288_908f_4427_905e_4413f7867ad3
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:6519
is: Q07837
is: SBO:0000252
constant: false
name: SLC3A1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110021#_bc44f149_b5d9_4848_953f_6d1bfc92132a
constant: false
is: O15270
name: SPTLC2
is encoded by: hsa:9517
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR ALCD2yf
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
modifier: MODEL1310110021#
is described by: ECO:0000134
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
product: MODEL1310110021#
type: Reaction
kinetic law: MODEL1310110021#
reversible: false
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD

metaM pristcoa c
has only substance units: false
name: pristanoyl coa
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: CHEBI:51341
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_31d3cbc9_6d61_4560_83f6_31894a72e234
is: SBO:0000252
is: Q5HYI4
initial concentration: NaN
is encoded by: hsa:6713
name: SQLE
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false

metaR EX CE1936 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: spermine dialdehyde exchange
type: Reaction

metaR ASPNATm
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.3.1.17 Confidence Level: 4 AUTHORS: PMID:11279290 NOTES:MM
kinetic law: MODEL1310110021#
name: aspartate N-acetyltransferase, mitochondrial
reversible: false
fast: false
product: MODEL1310110021#
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_5ffad7e2_e424_4be6_84e2_d4e33447f8d6
initial concentration: NaN
constant: false
is encoded by: hsa:7264
boundary condition: true
initial amount: NaN
name: TSTA3
has only substance units: false
is: Q13630
type: Species
is: SBO:0000252

metaM 5pmev x
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
initial amount: NaN
name: (R)-5-phosphonatomevalonate(3-)
is: HMDB01343
is: CHEBI:58146
type: Species
is: SBO:0000247

metaR PRAGSr
is version of: http://identifiers.org/ec-code/2.1.2.2
reactant: MODEL1310110021#
type: Reaction
name: phosphoribosylglycinamide synthase
kinetic law: MODEL1310110021#
fast: false
is described by: ECO:0000269
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110021#
is: SBO:0000176
reversible: true

metaR r2041
reactant: MODEL1310110021#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: MODEL1310110021#
is: SBO:0000185
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r0750
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
product: MODEL1310110021#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110021#
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110021#
reversible: true
type: Reaction
kinetic law: MODEL1310110021#

metaR r2201
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM dopa e
name: dopaminium(1+)
initial concentration: 1.0
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: SBO:0000247
initial amount: NaN
is: CHEBI:59905
boundary condition: false
has only substance units: false
constant: false
is: HMDB00073
type: Species

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR CDS
reactant: MODEL1310110021#
reversible: false
name: phosphatidate cytidylyltransferase
is: SBO:0000176
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.41
product: MODEL1310110021#
is described by: ECO:0000000

metaR CYTK2n
name: cytidylate kinase (dCMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110021#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
reactant: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_41bb35da_9b02_4968_8e18_cbfc27dda0a3
is: A8K761
constant: false
name: NDUFB10
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4716
initial concentration: NaN
initial amount: NaN

metaR GLCURtly
product: MODEL1310110021#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
kinetic law: MODEL1310110021#
name: glucuronate transport into lysososme
is: SBO:0000185
reversible: true
modifier: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_17c320c9_af9d_45e5_b57b_c278fef70c50
boundary condition: true
constant: false
initial amount: NaN
is: P49327
has only substance units: false
is: SBO:0000252
name: FASN
initial concentration: NaN
type: Species
is encoded by: hsa:2194

metaR r2314
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110021#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_46cf519d_46c3_44dc_8464_6dc98ac9d4bb
constant: false
initial amount: NaN
is encoded by: hsa:2645
has only substance units: false
is: SBO:0000252
name: GCK
initial concentration: NaN
is: Q53Y25
boundary condition: true
type: Species

metaM dcholcoa r
boundary condition: false
is: HMDB06292
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28701
has only substance units: false

metaR EX 3mlda LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange
type: Reaction

metaM HC01415 m
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:27537
has only substance units: false
name: (2E)-Octenoyl-CoA

metaM dolp L c
name: dolichyl phosphate(2-)
boundary condition: false
initial amount: NaN
is: CHEBI:57683
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

http://identifiers.org/biomodels.db/MODEL1310110021#_e61127ee_22f4_4489_b950_82e7b2dd8c12
is: SBO:0000252
is: E9PEI9
type: Species
initial concentration: NaN
boundary condition: true
name: LSS
is encoded by: hsa:4047
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c58bb34b_5086_4c92_affc_5fe45c60f958
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4126
name: MANBA
boundary condition: true
is: SBO:0000252
is: O00462
type: Species
initial amount: NaN

metaM ps hs c
initial amount: NaN
type: Species
name: ps_hs[c]
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
constant: false
boundary condition: false
is: CHEBI:18303
initial concentration: 1.0
is: SBO:0000247

metaM ncam e
notes: FORMULA: C6H6N2O CHARGE: 0
is: C00153
name: Nicotinamide
has only substance units: false
constant: false
is: CHEBI:0
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01406
boundary condition: false
initial amount: NaN

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaM lanost r
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: lanosterol
constant: false
boundary condition: false
is: HMDB01251
type: Species
has only substance units: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
is: CHEBI:16521

http://identifiers.org/biomodels.db/MODEL1310110021#_7f8c23c2_0875_4520_9e0b_df06839a8d16
has only substance units: false
initial amount: NaN
is: O95470
name: SGPL1
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8879
constant: false
boundary condition: true

metaM thym m
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:17821
initial amount: NaN
name: thymine
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: HMDB00262

http://identifiers.org/biomodels.db/MODEL1310110021#_14fcaeb8_24b6_4276_b9d8_a173949b4ec5
is encoded by: hsa:7357
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q16739
name: UGCG

metaR r1156
product: MODEL1310110021#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
fast: false
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

metaR r1884
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110021#
name: Y+LAT2 Utilized transport
product: MODEL1310110021#
kinetic law: MODEL1310110021#
is described by: ECO:0000000
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_65083cfb_951d_48b4_98b0_c214ffba8c56
name: ACSS1
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: Q9NUB1
is encoded by: hsa:84532

metaM leuktrE4 c
has only substance units: false
initial amount: NaN
boundary condition: false
name: leukotriene E4(1-)
is: HMDB02200
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
type: Species
is: CHEBI:57462
is: SBO:0000247
constant: false

metaR r2315
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110021#
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110021#
reversible: true
is: SBO:0000185
fast: false

metaR r2202
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is: SBO:0000185
modifier: MODEL1310110021#
reactant: MODEL1310110021#
product: MODEL1310110021#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110021#
is described by: ECO:0000000
reversible: true
fast: false

metaM amp e
has only substance units: false
is: HMDB00045
name: AMP
is: C00020
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false
is: CHEBI:456215
initial concentration: 1.0

metaM glyc S e
initial amount: NaN
has only substance units: false
is: CHEBI:33871
constant: false
name: (S)-Glycerate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: 0
type: Species
is: HMDB06372
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110021#_f93628de_09d1_4ba2_8a51_9328ec726844
is: SBO:0000252
name: SLC6A3
type: Species
initial concentration: NaN
is encoded by: hsa:6531
has only substance units: false
initial amount: NaN
constant: false
is: Q01959
boundary condition: true

metaR RIBt
is described by: ECO:0000000
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
reversible: true
product: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
fast: false
is: SBO:0000185
name: ribose transport via diffusion

metaM fmn e
is: C00061
type: Species
notes: FORMULA: C17H19N4O9P CHARGE: -2
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01520
name: FMN
is: CHEBI:58210
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0853
reversible: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
name: Facilitated diffusion
product: MODEL1310110021#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR UMPK4n
reactant: MODEL1310110021#
is: SBO:0000176
reversible: true
is described by: ECO:0000269
name: UMP kinase (GTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
type: Reaction
product: MODEL1310110021#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_e4c81eca_730f_4a64_8f12_9e82e3252100
boundary condition: true
is: SBO:0000252
name: CYP27A1
type: Species
initial concentration: NaN
initial amount: NaN
is: Q02318
has only substance units: false
constant: false
is encoded by: hsa:1593

http://identifiers.org/biomodels.db/MODEL1310110021#_a268e007_dbd5_4eec_bd3a_03b620ff6ce0
boundary condition: true
is: P28907
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:952
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: CD38

http://identifiers.org/biomodels.db/MODEL1310110021#_58a8f4e7_c0cc_4320_90b9_78ea4f628708
is: SBO:0000252
initial amount: NaN
is: P17858
constant: false
boundary condition: true
initial concentration: NaN
name: PFKL
type: Species
is encoded by: hsa:5211
has only substance units: false

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR DGCHOLte
name: bile acid intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
product: MODEL1310110021#
reactant: MODEL1310110021#
reversible: true

metaR r0752
fast: false
is: SBO:0000176
kinetic law: MODEL1310110021#
is described by: ECO:0000000
product: MODEL1310110021#
reactant: MODEL1310110021#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
type: Reaction
modifier: MODEL1310110021#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110021#_c94c958f_cf59_493f_92df_92eb8d79b0b9
name: PPA2
initial concentration: NaN
has only substance units: false
boundary condition: true
is: F8WDN9
is encoded by: hsa:27068
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_0a5c6272_91b3_403d_8239_66d9166e95f8
boundary condition: true
type: Species
is encoded by: hsa:6578
constant: false
name: SLCO2A1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q92959

metaR PRFGS
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.5.3
product: MODEL1310110021#
name: phosphoribosylformylglycinamidine synthase
kinetic law: MODEL1310110021#
modifier: MODEL1310110021#
fast: false
reactant: MODEL1310110021#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110021#_145eea6a_25de_4f53_ba30_ebffdb07c336
is: A0PJJ9
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:2686
boundary condition: true
name: GGT7

metaR r2316
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110021#

metaM xol7aone m
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:17899
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110021#_ab7db8d2_4c8f_4ae8_93ee_064671931e6f
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:2348
initial concentration: NaN
constant: false
initial amount: NaN
name: FOLR1
boundary condition: true

metaR RE3346M
product: MODEL1310110021#
type: Reaction
name: RE3346
is: SBO:0000176
reactant: MODEL1310110021#
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (217.1) or (219.1) or (501.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
modifier: MODEL1310110021#
is described by: ECO:0000000
kinetic law: MODEL1310110021#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_104fe312_22ae_4d58_984b_dea417851b44
is: SBO:0000252
is encoded by: hsa:8310
name: ACOX3
has only substance units: false
boundary condition: true
is: O15254
type: Species
initial amount: NaN
constant: false
initial concentration: NaN

metaR RE1447M
reactant: MODEL1310110021#
is: SBO:0000176
name: RE1447
is described by: ECO:0000000
modifier: MODEL1310110021#
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_ce7498a8_78f5_41c2_9d89_b4f5031a0583
name: GPI
type: Species
boundary condition: true
is encoded by: hsa:2821
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is: P06744

metaM Nacasp m
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
is: CHEBI:16953
has only substance units: false
name: N-acetyl-L-aspartate(2-)
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00812
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110021#_d28710cb_bb77_48d6_b09b_50373e5797b6
is: SBO:0000252
type: Species
boundary condition: true
constant: false
is encoded by: hsa:5230
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PGK1
is: P00558

metaM acac x
is: CHEBI:13705
is: HMDB00060
initial amount: NaN
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: acetoacetate
type: Species
boundary condition: false

metaM k e
type: Species
is: SBO:0000247
constant: false
is: CHEBI:29103
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
boundary condition: false
is: C00238
name: potassium
initial amount: NaN
is: HMDB00586
has only substance units: false
initial concentration: 1.0

metaM acmana c
is: SBO:0000247
name: N-acetyl-D-mannosamine
is: HMDB01129
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false
boundary condition: false
is: CHEBI:17122
has only substance units: false

metaR r0753
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
kinetic law: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
reactant: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/2.3.1.85

http://identifiers.org/biomodels.db/MODEL1310110021#_9cedc0b3_235a_4257_b38d_b6fad59ca326
is encoded by: hsa:762
is: Q6FHI7
name: CA4
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR ACACT1rm
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
product: MODEL1310110021#
modifier: MODEL1310110021#
reversible: true
kinetic law: MODEL1310110021#
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110021#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9

metaM focytC m
type: Species
initial concentration: 1.0
has only substance units: false
name: Ferrocytochrome C
is: CHEBI:16928
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
constant: false

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR r2317
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110021#
fast: false
kinetic law: MODEL1310110021#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
product: MODEL1310110021#
type: Reaction

metaR INSt
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
is: SBO:0000185
modifier: MODEL1310110021#
product: MODEL1310110021#
name: Inosine transport (diffusion)
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110021#
kinetic law: MODEL1310110021#

metaM sprm e
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:45725
initial concentration: 1.0
name: spermine(4+)
is: HMDB01256
boundary condition: false
type: Species
constant: false
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750

metaM leuktrE4 e
is: SBO:0000247
is: HMDB02200
constant: false
name: leukotriene E4(1-)
initial concentration: 1.0
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false
is: CHEBI:57462
initial amount: NaN
boundary condition: false
type: Species

metaM CE1940 e
type: Species
boundary condition: false
constant: false
name: spermidine monoaldehyde 2
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C7H18N2O CHARGE: 2 INCHI: InChI=1/C7H16N2O/c8-4-3-6-9-5-1-2-7-10/h7,9H,1-6,8H2/p+1 EHMN_ABBREVIATION: CE1940
is: HMDB02329
is: CHEBI:30623

metaR RE1804C
reactant: MODEL1310110021#
name: RE1804
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
type: Reaction
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110021#_c496def5_1439_4695_a360_92f6d87875a8
boundary condition: true
name: TK1
is: SBO:0000252
constant: false
is: P04183
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:7083
has only substance units: false

metaM fmn c
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: FMN
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial amount: NaN
is: C00061
is: SBO:0000247
type: Species
is: HMDB01520
is: CHEBI:58210
constant: false

metaM HC01162 c
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58376
constant: false
has only substance units: false
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

metaR PPItm
reactant: MODEL1310110021#
product: MODEL1310110021#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
is described by: ECO:0000134
is: SBO:0000185
fast: false
name: diphopshate transporter, mitochondrial
type: Reaction
kinetic law: MODEL1310110021#

metaR RE1447N
fast: false
is described by: ECO:0000000
reactant: MODEL1310110021#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
kinetic law: MODEL1310110021#
product: MODEL1310110021#
is: SBO:0000176

metaR ACOAD8m
is version of: http://identifiers.org/ec-code/1.3.99.10
type: Reaction
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110021#
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
modifier: MODEL1310110021#

http://identifiers.org/biomodels.db/MODEL1310110021#_e05b4b3c_1684_4c1c_863b_ba7594a57324
has only substance units: false
boundary condition: true
name: ADO
is encoded by: hsa:84890
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is: B3KXN9
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110021#_e1f59dce_9f76_4258_81a0_551c14798a74
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI971023
name: _AI971023_1_c
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110021#
reactant: MODEL1310110021#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR PROSTGF2t
kinetic law: MODEL1310110021#
name: prostaglandin uniport
modifier: MODEL1310110021#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110021#
product: MODEL1310110021#
type: Reaction
reversible: true
fast: false
is: SBO:0000185

metaR FAOXC102C81m
kinetic law: MODEL1310110021#
product: MODEL1310110021#
reactant: MODEL1310110021#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

W3 CDTF: Fri Aug 31 03:48:44 BST 2012