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type: Species
is: SBO:0000297
initial amount: NaN
constant: false
has only substance units: false
name: GUCY1B2:GUCY1A3
is encoded by: hsa:2982
has part: D6RDW3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2974

http://identifiers.org/biomodels.db/MODEL1310110013#_d008b539_8ede_4ee1_9f72_4ec38a387c1f
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: _PRO1933_1_m
initial concentration: NaN
is encoded by: hsa:PRO1933
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_eb038a65_e399_49f4_8c74_3897306141a4
is: P33121
name: ACSL1
constant: false
initial amount: NaN
is encoded by: hsa:2180
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

metaR ALAGLYexR
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
product: MODEL1310110013#
fast: false
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-alanine/glycine reversible exchange
reactant: MODEL1310110013#
is: SBO:0000185

metaR r1971
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#

metaM dcsptn1crn m
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl carnitine
boundary condition: false
is: HMDB06321
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

metaM oagt3 hs c
is: C00329
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:17315
is: HMDB01514
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
initial amount: NaN
boundary condition: false
name: 9-O-Acetylated GT3

metaR ACOAD9m
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reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110013#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
product: MODEL1310110013#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM

metaR CLFORtex
is: SBO:0000185
reversible: false
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#
name: chloride transport via formate countertransport
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
type: Reaction
is described by: ECO:0000304

metaM pail45p hs c
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:28910
has only substance units: false
boundary condition: false

metaM 2obut c
initial concentration: 1.0
is: HMDB00005
is: SBO:0000247
has only substance units: false
constant: false
name: 2-Oxobutanoate
boundary condition: false
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
is: CHEBI:16763
initial amount: NaN
is: C00109

http://identifiers.org/biomodels.db/MODEL1310110013#_bb85275b_83ef_43a3_9056_9b842c71d260
type: Species
name: PIK3CD:PIK3R1
has only substance units: false
is encoded by: hsa:5295
initial amount: NaN
is: SBO:0000297
boundary condition: true
initial concentration: NaN
has part: E7EX19
constant: false

metaM occoa m
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is: C01944
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57386
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01070
type: Species
name: Octanoyl-CoA (n-C8:0CoA)

metaM apoC Lys c
has only substance units: false
boundary condition: false
name: Apocarboxylase (Lys residue)
type: Species
initial amount: NaN
is: CHEBI:32551
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H13N2OX CHARGE: 0
is: HMDB00182

http://identifiers.org/biomodels.db/MODEL1310110013#_cddf3717_2f06_4b0b_b9f7_78e61d97ea26
is: P31040
has only substance units: false
is encoded by: hsa:6389
name: SDHA
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR MTHFCm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
product: MODEL1310110013#
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
reversible: true
modifier: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000269

metaM ocde9ecoa x
constant: false
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: 9-octadecenoylcoa

metaR PHACCOAGLNAC
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
reactant: MODEL1310110013#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110013#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_80ddc017_16eb_4674_a796_eff12c37674a
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P10768
is encoded by: hsa:2098
constant: false
is: SBO:0000252
name: ESD
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_149d1f94_0aeb_4e8a_ba0e_e86247203b7f
is encoded by: hsa:AI469183
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: _AI469183_1_x
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM arachd l
constant: false
initial concentration: 1.0
name: arachidonate
boundary condition: false
is: HMDB01043
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
initial amount: NaN

metaM tym c
is: HMDB00306
name: tyraminium
constant: false
is: SBO:0000247
is: CHEBI:327995
type: Species
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaM orot e
initial concentration: 1.0
initial amount: NaN
is: HMDB00226
has only substance units: false
constant: false
is: CHEBI:30839
is: SBO:0000247
name: orotate
type: Species
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295

http://identifiers.org/biomodels.db/MODEL1310110013#_0b2915f6_602f_4c5e_8edb_d8e7e0ed7ce1
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:9651
is: SBO:0000252
name: PLCH2
initial concentration: NaN
constant: false
is: O75038

http://identifiers.org/biomodels.db/MODEL1310110013#_cb95abc6_484f_4ed3_a9f6_dc33203ff946
is: P49189
boundary condition: true
type: Species
name: ALDH9A1
is encoded by: hsa:223
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaM ksi deg37 l
constant: false
boundary condition: false
is: HMDB01354
notes: FORMULA: C62H104N4O46 CHARGE: 0
initial concentration: 1.0
name: keratan sulfate I, degradation product 37
is: SBO:0000247
has only substance units: false
is: CHEBI:57455
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_f3c453e7_1e00_4d66_a35e_b79490002ba5
initial concentration: NaN
is encoded by: hsa:1565
boundary condition: true
type: Species
is: Q6NXU8
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: CYP2D6

metaM docohexcoa m
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
name: 2,4,7,10,13,16-docosahexenoylcoa
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_601e7f9b_7174_41d4_aaeb_45e45d7559b7
constant: false
is: SBO:0000252
initial amount: NaN
is: Q6ZWP6
is encoded by: hsa:27034
name: ACAD8
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM 5tedtricoa x
type: Species
name: 5,8,11-tetradecatrienoylcoa
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02288
has only substance units: false
is: SBO:0000247

metaM hedepecoa m
initial amount: NaN
name: 2,4,7,10,13-hexadecapentenoylcoa
is: HMDB02288
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C37H52N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110013#_33c186e9_4e31_4c4b_adad_acb8cc0c4637
initial amount: NaN
is encoded by: hsa:1757
initial concentration: NaN
is: SBO:0000252
constant: false
is: A8K596
boundary condition: true
has only substance units: false
name: SARDH
type: Species

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_9a6538a7_40de_4c98_b60f_e62cdcddcf98
is: Q02127
name: DHODH
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:1723
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_29a4dfb2_97d3_4241_9a1a_9ad801637358
type: Species
name: AK1
constant: false
is: P00568
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:203

metaR GALNTg
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.41
modifier: MODEL1310110013#
name: GalNAc transferase, Golgi apparatus
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
type: Reaction
reversible: false
is described by: ECO:0000000

metaM hpdcacoa c
type: Species
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
name: heptadecanoyl coa
has only substance units: false
is: HMDB06497
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM oagt3 hs e
name: 9-O-Acetylated GT3
type: Species
is: HMDB02168
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
has only substance units: false
is: CHEBI:18421
is: SBO:0000247
constant: false
boundary condition: false

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaM bilglcur r
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
is: SBO:0000247
is: CHEBI:57767
initial concentration: 1.0
initial amount: NaN
type: Species
name: mono(glucosyluronic acid)bilirubin(2-)
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_e4d1220e_2d3e_411f_9037_a688b317661e
name: HSD3B1
has only substance units: false
is: P14060
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:3283

metaM c226coa c
initial amount: NaN
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
type: Species
is: SBO:0000247
is: C16169
has only substance units: false
boundary condition: false
constant: false

metaM pchol hs m
is: CHEBI:16110
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Phosphatidylcholine
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

http://identifiers.org/biomodels.db/MODEL1310110013#_72169013_154d_43f1_bf7e_dced639dab7f
initial concentration: NaN
name: DGAT2
has only substance units: false
is: Q96PD7
initial amount: NaN
type: Species
is encoded by: hsa:84649
is: SBO:0000252
constant: false
boundary condition: true

metaM 5adtststerone r
is: CHEBI:16330
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
name: 17beta-hydroxy-5alpha-androstan-3-one
boundary condition: false
constant: false
is: HMDB02961
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM 1pyr5c m
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: CHEBI:15893
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
is: C03912
type: Species
name: 1-Pyrroline-5-carboxylate
initial concentration: 1.0
is: HMDB01301

metaR RE2069C
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11447235 NOTES:
name: RE2069
reactant: MODEL1310110013#

metaM ppi m
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: Diphosphate
is: CHEBI:33019
type: Species
is: HMDB00250
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: C00013

http://identifiers.org/biomodels.db/MODEL1310110013#_602ac7bc_51b8_4a2d_aa6e_1345251d7c5e
constant: false
type: Species
name: ADCY8
is encoded by: hsa:114
is: SBO:0000252
initial concentration: NaN
is: Q4F7X0
has only substance units: false
initial amount: NaN
boundary condition: true

metaR RPEc
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000134
type: Reaction
name: ribulose 5-phosphate 3-epimerase
is: SBO:0000176
reversible: true
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
kinetic law: MODEL1310110013#

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM HC00460 c
is: SBO:0000247
constant: false
has only substance units: false
name: 2,5-dihydroxybenzoate
is: CHEBI:58044
initial amount: NaN
boundary condition: false
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
type: Species
initial concentration: 1.0

metaR KHK2
modifier: MODEL1310110013#
reversible: false
name: ketohexokinase (D-xylulose)
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110013#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.3
type: Reaction

metaM arachd e
has only substance units: false
name: arachidonate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395
is: HMDB01043

metaR DNDPt13m
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000185
name: dADP transport via ATP antiport
reactant: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM 4hpro LT e
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
boundary condition: false
name: trans-4-hydroxy-L-proline
is: SBO:0000247
is: HMDB00725
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_3eb9caf1_cfbe_4cb7_bdaa_2db2c417ee7a
is: SBO:0000252
name: COX8A
is encoded by: hsa:1351
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: Q53XN1

metaM arachdcoa x
initial amount: NaN
is: HMDB06523
boundary condition: false
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
constant: false
type: Species
is: SBO:0000247

metaM oagt3 hs g
has only substance units: false
notes: FORMULA: C65H106N4O37FULLRCO CHARGE: -3
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: 9-O-Acetylated GT3
initial concentration: 1.0
is: HMDB01514
is: C00329
boundary condition: false
is: CHEBI:17315

metaR ACACT1x
product: MODEL1310110013#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
name: acetyl-CoA C-acetyltransferase, mitochondrial
is described by: ECO:0000134
reactant: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version

http://identifiers.org/biomodels.db/MODEL1310110013#_b6df2996_4f62_4ba9_908a_49efafa9f479
name: FOLR1
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2348
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_74ca6efc_2112_4a9b_a052_65fad4d595db
is encoded by: hsa:3030
boundary condition: true
initial amount: NaN
name: HADHA
has only substance units: false
constant: false
is: E9KL44
initial concentration: NaN
is: SBO:0000252
type: Species

metaR RE0453C
is: SBO:0000176
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
name: RE0453
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
kinetic law: MODEL1310110013#

metaR RE1709C
type: Reaction
is: SBO:0000176
name: RE1709
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true

metaR r0381
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110013#
type: Reaction
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3

metaR HISD
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.3.1.3
modifier: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false
name: histidase

metaM xoldioloneh c
is: HMDB06887
has only substance units: false
initial amount: NaN
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
boundary condition: false
initial concentration: 1.0
is: CHEBI:2288
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
type: Species
is: SBO:0000247

metaR GULNDer
kinetic law: MODEL1310110013#
name: gulonate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_d85d93c5_96aa_441a_baf2_9b5525a0a134
initial amount: NaN
constant: false
is encoded by: hsa:5959
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: RDH5
type: Species
is: Q92781
has only substance units: false

metaR r0276
modifier: MODEL1310110013#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.21
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176

metaR GCC2am
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoamide), mitochondrial
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
fast: false
is described by: ECO:0000269
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction

metaM ethamp c
is: SBO:0000247
is: CHEBI:58190
type: Species
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00224
name: ethamp[c]
initial concentration: 1.0
boundary condition: false

metaR CYTK14n
type: Reaction
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
fast: false
is: SBO:0000176
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM udp r
type: Species
name: UDP
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: C00015
constant: false
is: CHEBI:58223
has only substance units: false
is: HMDB00295
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR P4502A6
notes: GENE_ASSOCIATION: (1553.1) or (1548.1) SUBSYSTEM: Cytochrome metabolism EC Number: 1.14.14.1 Confidence Level: 4 AUTHORS: PMID:15579107,PMID:9827545 NOTES:coumarin: 7 hydroxylation assumed to take place on outer membrane - xenobiotic metabolism NJ
is version of: http://identifiers.org/ec-code/1.14.14.1
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
name: cytochrome P450 2A6
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR FAOXC102C101x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_7bece98f_0215_4d44_a905_6543f97f20c7
is encoded by: hsa:8803
boundary condition: true
has only substance units: false
has part: E5KS60
constant: false
type: Species
initial concentration: NaN
name: SUCLG1:SUCLA2
is: SBO:0000297
initial amount: NaN

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM nh4 c
type: Species
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C01342
has only substance units: false
is: HMDB00051
is: CHEBI:28938
name: Ammonium
initial amount: NaN

metaR RE3000M
type: Reaction
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#
name: RE3000

metaR r0384
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
fast: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2

metaM 4hpro LT c
is: HMDB00725
initial amount: NaN
initial concentration: 1.0
type: Species
name: trans-4-hydroxy-L-proline
boundary condition: false
constant: false
is: CHEBI:18095
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_1d970ce2_aabb_40cf_8423_7eee8506b593
name: GPX7
is encoded by: hsa:2882
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: Q96SL4
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_a1339dea_cf57_4199_bb7b_b541d7fd709f
is: Q6LEN5
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1103
type: Species
initial amount: NaN
name: CHAT
is: SBO:0000252
has only substance units: false

metaR EX npthl LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Naphthalene exchange
type: Reaction

metaM pristcoa x
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
is: CHEBI:51341
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaR r0386
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
reactant: MODEL1310110013#
reversible: false
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110013#

metaM c226coa m
constant: false
boundary condition: false
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
is: C16169
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
type: Species

metaR RE0453N
product: MODEL1310110013#
reversible: true
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: RE0453
is: SBO:0000176
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

metaM apoC Lys m
name: Apocarboxylase (Lys residue)
is: CHEBI:32551
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: HMDB00182

metaR r2310
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110013#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_842aabc2_dda9_47e9_9934_4d266ac6ce73
type: Species
constant: false
is encoded by: hsa:1716
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: DGUOK
is: E5KSL5
initial concentration: NaN
has only substance units: false

metaM nh4 e
initial amount: NaN
is: HMDB00051
is: CHEBI:28938
constant: false
name: ammonium
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaM CE4794 m
has only substance units: false
boundary condition: false
constant: false
type: Species
name: cis-6-dodecenoyl-CoA
is: SBO:0000247
initial amount: NaN
is: CHEBI:57923
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794

metaM tettet6coa x
constant: false
is: http://identifiers.org/pubchem.compound/47205481
name: tetracosatetraenoyl coenzyme A
has only substance units: false
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB06516
initial amount: NaN
is: C16171

metaM ahcys e
is: CHEBI:16680
initial amount: NaN
is: C00021
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0
name: S-Adenosyl-L-homocysteine
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00939

metaR DADA
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
type: Reaction
fast: false
name: Deoxyadenosine deaminase
is version of: http://identifiers.org/ec-code/3.5.4.4
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176

metaM arachd r
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
constant: false
type: Species
is: CHEBI:32395
name: arachidonate
is: HMDB01043
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR HPDCACRNt
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
type: Reaction
name: heptadecanoate transport into the mitochondria
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ

metaR PROt4 2 r
fast: false
reversible: true
is: SBO:0000185
name: Proline transport (sodium symport) (2:1)
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
is described by: ECO:0000006
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_5505c72d_3cc2_47e2_8486_e6d13523b904
is: Q8IYH3
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: HAS1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3036

metaR HIBDm
is version of: http://identifiers.org/ec-code/1.1.1.31
is: SBO:0000176
product: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
fast: false
reversible: true
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_b4e94197_6b16_4b33_a11f_544d8dbdf4a5
is: SBO:0000252
name: SDR16C5
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is: B3KT84
is encoded by: hsa:195814
constant: false
boundary condition: true

metaM udp n
initial amount: NaN
name: UDP(3-)
is: CHEBI:58223
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_d5fcf42b_558c_4b9e_9d55_f638aa7b07c3
name: SLC2A9
is: Q9NRM0
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:56606
boundary condition: true

metaR APOCF
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
name: Apocarboxylase formation
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false

metaM ksi deg21 l
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: keratan sulfate I, degradation product 21
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
is: SBO:0000247

metaR RE1447M
modifier: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
is described by: ECO:0000000
fast: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.41

metaM 2hexdtricoa m
name: 2,7,10-hexadecatrienoylcoa
has only substance units: false
boundary condition: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN

metaR r0388
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
reversible: true
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:

metaR AATAi
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.7
notes: GENE_ASSOCIATION: (51166.1) or (51166.2) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 4 AUTHORS: PMID:12126930 NOTES:MM
fast: false
kinetic law: MODEL1310110013#
name: 2-aminoadipate transaminase, irreversible
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
reversible: false
product: MODEL1310110013#
is: SBO:0000176

metaM ahcys c
initial amount: NaN
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
name: S-Adenosyl-L-homocysteine
has only substance units: false
is: HMDB00939
initial concentration: 1.0
boundary condition: false
type: Species
is: C00021
is: CHEBI:16680
is: SBO:0000247

metaR r2312
is described by: ECO:0000000
reversible: true
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR GLUDxm
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is version of: http://identifiers.org/ec-code/1.4.1.3
modifier: MODEL1310110013#
is described by: ECO:0000269
is: SBO:0000176
name: glutamate dehydrogenase (NAD) (mitochondrial)
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#

metaM 2obut m
is: HMDB00005
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
name: 2-oxobutanoate
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16763

metaM pail45p hs m
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:28910
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

http://identifiers.org/biomodels.db/MODEL1310110013#_f8d0970f_bf58_41e7_b4ef_1e70b0615acc
name: SLC16A10
initial amount: NaN
constant: false
is: Q8TF71
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:117247
boundary condition: true

metaM 2ddecdicoa x
is: HMDB11123
is: C05279
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
type: Species
name: 2,6-dodecadienoylcoa
constant: false
has only substance units: false
is: SBO:0000247

metaR RE1447N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
fast: false
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_1495f2df_3ebf_49ce_ae32_cb42315ee99b
has only substance units: false
name: NDUFV1
is: SBO:0000252
type: Species
boundary condition: true
is: E5KNH5
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4723

http://identifiers.org/biomodels.db/MODEL1310110013#_f797a53f_be3d_474a_a21a_7f5cd748c1f2
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:39
has only substance units: false
is: Q9BWD1
boundary condition: true
name: ACAT2
constant: false
initial amount: NaN

metaM pail45p hs n
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
boundary condition: false
initial concentration: 1.0

metaR FAS120COA
is described by: ECO:0000269
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
is: SBO:0000176
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C12:0CoA)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7aca22f2_3be4_4391_afd0_ae352790f75c
name: IDH3B
initial amount: NaN
is encoded by: hsa:3420
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR r2311
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
kinetic law: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_2569afb0_d4ad_4f9a_a777_d35fb0bc1108
is encoded by: hsa:4512
initial concentration: NaN
constant: false
boundary condition: true
name: COX1
has only substance units: false
is: SBO:0000252
type: Species
is: Q7GXY8
initial amount: NaN

metaR ASAH1
type: Reaction
product: MODEL1310110013#
name: N-acylsphingosine amidohydrolase
reversible: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
is: SBO:0000176
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.23
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM ppi n
boundary condition: false
name: diphosphate(3-)
type: Species
initial amount: NaN
is: CHEBI:33019
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM HC01377 m
constant: false
is: CHEBI:27462
boundary condition: false
type: Species
initial concentration: 1.0
name: S-(3-Methylbutanoyl)-dihydrolipoamide
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM udpg c
has only substance units: false
is: HMDB00286
is: C00029
name: UDPglucose
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
boundary condition: false
is: CHEBI:58367

metaR r0129
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
fast: false
modifier: MODEL1310110013#

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR S6TASE16ly
reversible: true
is: SBO:0000176
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.6.14

metaR FAOXC102C101m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR r2314
is described by: ECO:0000000
reversible: true
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110013#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110013#

metaM vacccoa c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1
is: HMDB06521
type: Species
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/9543677
name: vaccenyl coenzyme A

metaR RE3079X
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
reversible: true
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton
name: RE3079
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000

metaR IZPN
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110013#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110013#
name: Imidazolonepropionase
reversible: false

metaM occoa x
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
boundary condition: false
initial concentration: 1.0
is: CHEBI:57386
constant: false
has only substance units: false
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
is: C01944
type: Species
is: SBO:0000247
initial amount: NaN

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_bd900e83_c5a2_44cb_80ec_25be903b8f80
initial amount: NaN
has only substance units: false
constant: false
name: _AI684467_1_m
is: SBO:0000252
type: Species
is encoded by: hsa:AI684467
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_34ad25e3_44c3_4c81_bbe8_46916cb09aaa
has only substance units: false
is encoded by: hsa:25769
is: Q9UI40
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC24A2
initial amount: NaN

metaR r2313
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110013#
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_a0ea78fa_377a_4621_9adf_adaf78bee57d
is: SBO:0000252
name: COX8C
boundary condition: true
is encoded by: hsa:341947
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: Q7Z4L0

metaR PRGNLONEtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
name: pregnenolone intracellular transport
is: SBO:0000185
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false

metaR r0389
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000

metaR RE3626M
fast: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
name: RE3626
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
reversible: false
modifier: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_1f740eeb_92eb_42ff_a517_a6d59b6eb34a
initial concentration: NaN
is: P28329
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:1103
boundary condition: true
type: Species
is: SBO:0000252
name: CHAT

metaR RE1519M
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110013#
reactant: MODEL1310110013#
name: RE1519
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
modifier: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true

metaM udpg e
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
has only substance units: false
type: Species
constant: false
is: HMDB00286
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: CHEBI:58367
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_cf36f7a6_4516_44c2_8793_b05f71cce834
constant: false
is encoded by: hsa:114134
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is: Q96QE2
name: SLC2A13
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_058c4146_2f88_426e_a337_bddcb09a219c
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: O76074
is encoded by: hsa:8654
name: PDE5A
is: SBO:0000252
has only substance units: false

metaR MTHFD2m
reversible: true
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000254
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
product: MODEL1310110013#
type: Reaction

metaR r1650
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
fast: false
is: SBO:0000185

metaM pchol hs r
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
boundary condition: false
type: Species
name: Phosphatidylcholine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_44a30ba4_8675_4dd9_a8b5_ccf6a1ca3693
is: SBO:0000252
initial amount: NaN
is: O43451
type: Species
name: MGAM
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8972
boundary condition: true

metaR r2316
reactant: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false

metaM udp l
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: UDP(3-)
is: SBO:0000247
is: CHEBI:58223
boundary condition: false
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_2df9816b_62ed_4f4b_8e12_2f72e18e5fc9
is: Q9H2B4
name: SLC26A1
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:10861
initial concentration: NaN
initial amount: NaN
type: Species

metaR RE1709N
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
modifier: MODEL1310110013#
name: RE1709

metaM ppi r
initial amount: NaN
is: SBO:0000247
type: Species
name: Diphosphate
is: C00013
is: CHEBI:33019
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250

metaR r1651
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
reversible: true

metaM docohexcoa x
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
name: 2,4,7,10,13,16-docosahexenoylcoa
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR RE0453M
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
kinetic law: MODEL1310110013#
fast: false
reversible: true

metaR FAOXC16OHC16r
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_ac7322e1_7e58_4b19_9876_8e24bc7d0748
is: SBO:0000252
is encoded by: hsa:AI620219
has only substance units: false
boundary condition: true
initial amount: NaN
name: _AI620219_1_c
initial concentration: NaN
constant: false
type: Species

metaM cs a deg5 l
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
boundary condition: false
is: SBO:0000247
is: CHEBI:15936
notes: FORMULA: C23H36O24S CHARGE: -2

metaR SMPD4
fast: false
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110013#
name: sphingomyelinase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
kinetic law: MODEL1310110013#
is described by: ECO:0000000

metaM 4hpro LT m
has only substance units: false
name: trans-4-hydroxy-L-proline
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00725
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18095

metaM acnam c
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:35418
constant: false
is: HMDB00230
name: N-acetylneuraminate

http://identifiers.org/biomodels.db/MODEL1310110013#_c520f773_625e_4b52_9cf1_0c043d917e3e
is: Q86SF2
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:51809
initial concentration: NaN
name: GALNT7
type: Species
has only substance units: false

metaR HSPGtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
reversible: false
name: heparan sulfate transport, extracellular to lysosome
is described by: ECO:0000000
kinetic law: MODEL1310110013#

metaR r2315
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110013#

metaM udp e
boundary condition: false
initial concentration: 1.0
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
is: HMDB00295
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_14a26374_7fb7_42cd_8894_7bd25bc5a0b1
constant: false
has only substance units: false
is encoded by: hsa:57786
boundary condition: true
type: Species
name: RBAK
initial concentration: NaN
is: Q9NYW8
initial amount: NaN
is: SBO:0000252

metaR ENGASEly
kinetic law: MODEL1310110013#
name: endo-beta-N-acetylglucosaminidase, lysosomal
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110013#
type: Reaction

metaM CE0693 m
is: CHEBI:28387
is: HMDB11123
type: Species
boundary condition: false
name: 3-oxolaur-6-cis-enoyl-CoA
has only substance units: false
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_434aa0e9_bc4e_49e0_986e_a980dbad23b6
initial amount: NaN
is: SBO:0000252
type: Species
name: NNT
has only substance units: false
initial concentration: NaN
is: Q13423
boundary condition: true
constant: false
is encoded by: hsa:23530

http://identifiers.org/biomodels.db/MODEL1310110013#_39e5e4d0_8804_4b03_ba06_48307edd3a76
is: Q9NST1
is encoded by: hsa:80339
has only substance units: false
constant: false
type: Species
name: PNPLA3
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_7c171436_289e_4366_aa85_9bd8186b3a80
constant: false
type: Species
is: SBO:0000252
name: RRM1
is encoded by: hsa:6240
has only substance units: false
initial concentration: NaN
is: P23921
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_9aae67ac_c72a_47a9_a6ec_d9a5a0acc28a
is encoded by: hsa:4882
name: NPR2
constant: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P20594
has only substance units: false

metaR r1641
modifier: MODEL1310110013#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#

metaM nh4 n
type: Species
boundary condition: false
is: CHEBI:28938
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
initial concentration: 1.0
name: ammonium
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_804c588c_50de_4d53_a3cb_560abe20935f
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:2348
has only substance units: false
boundary condition: true
name: FOLR1

metaM triodthy c
is: SBO:0000247
has only substance units: false
is: HMDB00265
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:18258
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
name: 3,3',5-triiodo-L-thyronine

metaM leuktrB4 c
has only substance units: false
name: leukotriene B4(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01085
is: CHEBI:57461

metaR RE1804M
name: RE1804
reversible: true
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15

metaM ahcys m
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16680
is: C00021
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00939
type: Species
name: S-Adenosyl-L-homocysteine

metaM q10h2 e
name: Ubiquinol-10
constant: false
is: SBO:0000247
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial amount: NaN

metaM dag hs c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18035
constant: false
type: Species
is: SBO:0000247
has only substance units: false
name: diglyceride
boundary condition: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0

metaM ala L e
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
name: L-alanine
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00161
type: Species
boundary condition: false
is: SBO:0000247

metaM acnam n
has only substance units: false
constant: false
is: CHEBI:35418
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0
is: SBO:0000247
name: N-acetylneuraminate
is: HMDB00230
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_eae592ee_8ba4_4eaa_9ed6_1d4d764e83fb
type: Species
is: Q5SPY7
is encoded by: hsa:954
name: ENTPD2
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM nh4 m
initial amount: NaN
initial concentration: 1.0
name: Ammonium
has only substance units: false
constant: false
type: Species
is: CHEBI:28938
is: C01342
is: HMDB00051
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false

metaR r1640
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000000
type: Reaction

metaR A4GALTg
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.4.1.228
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
fast: false
kinetic law: MODEL1310110013#
type: Reaction
name: Lactosylceramide 4-alpha-galactosyltransferase
is described by: ECO:0000269
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false
is: SBO:0000176

metaM xoldiolone c
initial amount: NaN
is: HMDB02197
is: CHEBI:28477
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false

metaM arachdcoa c
is: SBO:0000247
has only substance units: false
type: Species
constant: false
name: arachidonoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
boundary condition: false
initial amount: NaN
is: CHEBI:57368

metaM nad x
type: Species
constant: false
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
is: SBO:0000247
is: C00003
initial amount: NaN
is: HMDB00902
is: CHEBI:57540
boundary condition: false

metaM udp g
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58223
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
boundary condition: false
initial amount: NaN
name: UDP(3-)
type: Species

metaM n2m2mn l
initial concentration: 1.0
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
has only substance units: false
initial amount: NaN
notes: FORMULA: C42H71N3O31 CHARGE: 0
is: HMDB00939
is: CHEBI:16680
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaM apoC Lys btn m
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: http://identifiers.org/pubchem.compound/7886
initial amount: NaN
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial concentration: 1.0
is: HMDB03134
constant: false
is: C05552
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_2781671a_ef6d_457a_a3c9_289c4cf6d33d
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: ABCD1
is encoded by: hsa:215
is: P33897

http://identifiers.org/biomodels.db/MODEL1310110013#_7b244893_11ed_4b5a_8c79_20bc674e8620
is encoded by: hsa:AI024818
initial concentration: NaN
initial amount: NaN
type: Species
name: _AI024818_1_c
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR RE2759X
name: RE2759
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.99.4
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (23600.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.1.99.4 Confidence Level: 0 AUTHORS: PMID:11060344,PMID:11060359 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_7a6b2659_41c9_467a_9355_0f67af31b87e
constant: false
type: Species
name: PI4KB
is: SBO:0000252
initial amount: NaN
is: Q9UBF8
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5298
boundary condition: true

metaR r1643
is described by: ECO:0000000
modifier: MODEL1310110013#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1378
fast: false
product: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM cys L e
is: CHEBI:17561
type: Species
name: L-cysteine
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00574
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4e007ba1_0486_4501_a7d0_f4b7a2d760bc
initial amount: NaN
is encoded by: hsa:6568
type: Species
boundary condition: true
name: SLC17A1
is: Q14916
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM q10h2 c
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
type: Species
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
constant: false

metaR r2308
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110013#
type: Reaction
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_2667448d_e200_456b_85a7_c2e8629e1411
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:7086
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: TKT
is: E7EPA7

metaM gluala e
constant: false
name: 5-L-Glutamyl-L-alanine
is: SBO:0000247
type: Species
is: HMDB06248
is: http://identifiers.org/pubchem.compound/6503
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C03740
initial amount: NaN
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740

metaR FACOAL140i
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (tetradecanoate)
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
product: MODEL1310110013#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_3de971aa_73da_4f55_9080_274aac307366
name: MAOA
boundary condition: true
constant: false
is encoded by: hsa:4128
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: Q53YE7
is: SBO:0000252

metaR r1377
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110013#
is: SBO:0000176
reversible: true

metaR HCOUMARINte
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
name: xenobiotic transport
reactant: MODEL1310110013#
fast: false
is: SBO:0000185

metaR r1642
fast: false
is: SBO:0000185
reactant: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110013#
reversible: true
type: Reaction

metaM dag hs e
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: CHEBI:18035
constant: false
is: SBO:0000247
type: Species
name: diglyceride

http://identifiers.org/biomodels.db/MODEL1310110013#_dce6d8cf_d92d_45ae_be00_dd18cd9895c9
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR BTNDm
modifier: MODEL1310110013#
is: SBO:0000176
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is version of: http://identifiers.org/ec-code/3.5.1.12
type: Reaction
reversible: false
reactant: MODEL1310110013#
is described by: ECO:0000269
kinetic law: MODEL1310110013#
name: biotinidase (biotin), mitochondrial

metaR r1645
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
reactant: MODEL1310110013#

metaR r2309
kinetic law: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM ahcys r
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
is: SBO:0000247
is: CHEBI:16680
boundary condition: false
type: Species
name: S-adenosyl-L-homocysteine
constant: false

metaM 2hexdtricoa x
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 2,7,10-hexadecatrienoylcoa
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02288
type: Species
is: SBO:0000247
boundary condition: false

metaM dhcholestanate c
initial concentration: 1.0
is: CHEBI:16577
is: HMDB00359
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
constant: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

metaM chlstol r
type: Species
initial concentration: 1.0
is: CHEBI:16290
boundary condition: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06842

metaR S3TASE3ly
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110013#
name: N-acetylglucosamine-3-sulfatase, lysosomal
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false

metaM dcyt e
name: Deoxycytidine
is: HMDB00014
is: CHEBI:15698
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C00881

metaM cys L c
constant: false
is: CHEBI:17561
name: L-cysteine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
initial amount: NaN
is: HMDB00574
has only substance units: false
type: Species

metaR SUCCt4 2
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
modifier: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
name: succinate transport via sodium symport
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#

metaR r1644
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110013#
is: SBO:0000185
reversible: true

metaR HSD3B11
reactant: MODEL1310110013#
reversible: false
fast: false
product: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
type: Reaction
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.145

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaM HC02023 r
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:46898
initial amount: NaN
name: Cholesterol-ester-ol
initial concentration: 1.0
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
constant: false

metaR r1647
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: true
modifier: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_46e4cb8b_9db0_4e2c_8577_5706a428397d
is encoded by: hsa:6611
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: SMS
is: SBO:0000252
initial amount: NaN
is: P52788
has only substance units: false

metaR r2020
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
reversible: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM udp c
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
constant: false
has only substance units: false
is: C00015
is: HMDB00295
is: CHEBI:58223
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: UDP

metaM adpcoa x
boundary condition: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
is: C14143
name: adipoylcoa
is: HMDB04047
initial concentration: 1.0
constant: false

metaM triodthy e
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
boundary condition: false
is: HMDB00265
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: SBO:0000247
is: CHEBI:18258
has only substance units: false
constant: false
initial concentration: 1.0

metaM leuktrB4 e
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
has only substance units: false
name: leukotriene B4(1-)
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:57461
is: HMDB01085
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_84bbd680_e51d_403f_a177_e52669c108d1
is: SBO:0000252
is encoded by: hsa:1431
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
name: CS
type: Species
is: O75390

http://identifiers.org/biomodels.db/MODEL1310110013#_7511bfe6_8965_42a4_a8f9_2cbdbef34b08
name: ALDOB
initial concentration: NaN
has only substance units: false
is: P05062
type: Species
boundary condition: true
is encoded by: hsa:229
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_3ac8582b_6d74_4a45_807e_9f3f3474ffe8
name: GALNTL2
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: Q8N3T1
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:117248

metaR FAOXC161C141x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaR ONPTHLte
is: SBO:0000185
reversible: true
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
name: xenobiotic transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_73dce1b9_a45b_4a99_bfa7_a7e4bc9fa030
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:M68895
type: Species
has only substance units: false
name: _M68895_1_c
boundary condition: true
initial amount: NaN
constant: false

metaM dcyt c
is: C00881
name: Deoxycytidine
is: CHEBI:15698
type: Species
is: HMDB00014
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_ae20eadf_8652_4952_b9a4_1631c11d2dd8
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5092
type: Species
is: SBO:0000252
constant: false
name: PCBD1
is: P61457

metaR r1646
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_5fe00978_ae51_42e1_bff6_383fc824b01b
is: Q9UJM8
is encoded by: hsa:54363
has only substance units: false
boundary condition: true
initial amount: NaN
name: HAO1
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

metaM acnam l
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:35418
constant: false
is: SBO:0000247
is: HMDB00230
name: N-acetylneuraminate
has only substance units: false
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

http://identifiers.org/biomodels.db/MODEL1310110013#_b12db7dc_8a85_407b_8000_1c6b0d5b9181
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4191
constant: false
has only substance units: false
boundary condition: true
is: P40926
type: Species
initial concentration: NaN
name: MDH2

metaM ala L c
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
is: CHEBI:16977
constant: false
is: HMDB00161
initial concentration: 1.0
is: SBO:0000247
name: L-alanine
type: Species
initial amount: NaN
has only substance units: false

metaR SBT Dtde
name: D-sorbitol transport, extracellular
reactant: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

metaR CYOOm3
fast: false
name: cytochrome c oxidase, mitochondrial Complex IV
is described by: ECO:0000134
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.9.3.1
reversible: false
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
reactant: MODEL1310110013#

metaM crvnc e
is: SBO:0000247
notes: FORMULA: C22H31O2 CHARGE: -1
initial amount: NaN
type: Species
constant: false
is: HMDB02183
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: cervonic acid, C22:6 n-3
is: CHEBI:36005

http://identifiers.org/biomodels.db/MODEL1310110013#_df8a4395_36aa_42c8_8bae_f3e42f9045b5
constant: false
is: SBO:0000252
name: AMACR
is: Q3KT79
has only substance units: false
is encoded by: hsa:23600
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaR 3SPYRSPm
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110013#_895a891c_d862_47ef_ab22_b9bbff3e217e
initial amount: NaN
boundary condition: true
type: Species
name: MTHFD2
is encoded by: hsa:10797
has only substance units: false
is: P13995
is: SBO:0000252
constant: false
initial concentration: NaN

metaM cspg a l
constant: false
is: SBO:0000247
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
boundary condition: false
has only substance units: false
is: HMDB02183
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: CHEBI:36005
initial concentration: 1.0
type: Species

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR ENGASE2ly
kinetic law: MODEL1310110013#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176

metaR DURIt
reversible: true
type: Reaction
product: MODEL1310110013#
name: deoxyuridine transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110013#
fast: false

metaM 5tedtricoa m
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
type: Species
name: 5,8,11-tetradecatrienoylcoa
boundary condition: false
is: HMDB02288

metaM pchol hs g
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial amount: NaN
is: CHEBI:16110
is: SBO:0000247
type: Species
initial concentration: 1.0
name: Phosphatidylcholine
boundary condition: false
constant: false
has only substance units: false

metaM apoC Lys btn c
constant: false
is: CHEBI:32551
is: HMDB00182
type: Species
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
boundary condition: false
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN

W3 CDTF: Thu Aug 30 19:58:42 BST 2012

metaR r1649
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM arachdcoa m
is: CHEBI:57368
initial concentration: 1.0
is: HMDB06523
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species
initial amount: NaN
boundary condition: false
constant: false
name: arachidonoyl-CoA(4-)
has only substance units: false

metaM CE0785 m
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
type: Species
initial concentration: 1.0
is: CHEBI:57795
name: cis,cis-myristo-5,8-dienoyl-CoA
boundary condition: false
initial amount: NaN

metaR HSAT2ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
product: MODEL1310110013#
is described by: ECO:0000000
reversible: false

metaM xylu D c
is: HMDB01644
is: SBO:0000247
is: CHEBI:17140
has only substance units: false
type: Species
name: D-xylulose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaM cs b deg1 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
is: HMDB01354
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:57455
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
initial concentration: 1.0
boundary condition: false
constant: false

metaR LEUKTRD4t
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
name: leukotriene D4 transport
is: SBO:0000185
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110013#
fast: false

metaR r1648
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_02aead44_905d_4db6_93b8_732f188e23f0
is encoded by: hsa:6472
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: SHMT2
initial concentration: NaN
is: B4DJQ3
has only substance units: false
boundary condition: true

metaM q10h2 m
constant: false
boundary condition: false
is: HMDB13111
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247
initial amount: NaN

metaM dhcholestanate m
is: HMDB00359
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
constant: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: CHEBI:16577
boundary condition: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM crvnc c
notes: FORMULA: C22H31O2 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02183
constant: false
name: cervonic acid, C22:6 n-3
is: CHEBI:36005

http://identifiers.org/biomodels.db/MODEL1310110013#_e7fa118f_7fa7_4507_94d5_5fe779391853
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P46459
is encoded by: hsa:4905
name: NSF
constant: false
type: Species
boundary condition: true
has only substance units: false

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

W3 CDTF: Thu Aug 30 19:58:41 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110013#_1d96b96d_e188_4e17_ba99_4691013fb1c9
type: Species
is: SBO:0000252
is: Q5MY95
boundary condition: true
name: ENTPD8
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:377841

http://identifiers.org/biomodels.db/MODEL1310110013#_d2411a29_2f25_424a_a2ce_b70e5d4a3dd8
boundary condition: true
is: SBO:0000252
is: P16442
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:28
initial amount: NaN
has only substance units: false
name: ABO

metaR ARGtm
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reversible: true
reactant: MODEL1310110013#
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110013#
name: arginine mitochondrial transport via ornithine carrier
kinetic law: MODEL1310110013#

metaM galgluside hs l
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial concentration: 1.0
boundary condition: false
name: galactosyl glucosyl ceramide
has only substance units: false
initial amount: NaN
is: HMDB00143
type: Species
constant: false

metaR ASPTA
is: SBO:0000176
name: aspartate transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110013#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
fast: false
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#

metaR FAOXC226m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaM arachd c
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
type: Species
name: arachidonate
boundary condition: false
is: CHEBI:32395
is: HMDB01043
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM HC02203 e
is: SBO:0000247
boundary condition: false
name: prostaglandin-a2
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false

W3 CDTF: Thu Aug 30 19:58:42 BST 2012

metaR BACCL
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.4.10
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
reversible: false
name: biotin-[acetyl-CoA-carboxylase] ligase
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_3fdfb13d_af4d_494d_b71b_14a43f0bc4f1
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:9962
name: SLC23A2
type: Species
initial amount: NaN
initial concentration: NaN

metaM nh4 x
boundary condition: false
type: Species
is: C01342
has only substance units: false
initial amount: NaN
is: CHEBI:28938
name: Ammonium
is: HMDB00051
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

http://identifiers.org/biomodels.db/MODEL1310110013#_58b834a2_d95c_4ba4_83ca_ee1f62dfe245
name: ENO1
type: Species
is: E2DRY6
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2023
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_638364e2_81a9_4655_86dc_d2102fa86c30
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:5315
has only substance units: false
is: SBO:0000252
name: PKM2
boundary condition: true
type: Species

metaR r0494
product: MODEL1310110013#
type: Reaction
fast: false
reactant: MODEL1310110013#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110013#
is: SBO:0000176

metaM xol7a r
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
boundary condition: false
is: SBO:0000247
is: HMDB01496
has only substance units: false
initial concentration: 1.0
name: 20-hydroxycholesterol
type: Species
is: CHEBI:1296
initial amount: NaN

metaR SR5ARr
product: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.5
is: SBO:0000176
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
reactant: MODEL1310110013#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110013#_fbbe8876_ffd2_4a22_a8fa_1ea562cac313
constant: false
initial concentration: NaN
initial amount: NaN
name: SLC8A3
is encoded by: hsa:6547
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_f2f48138_1be3_4311_9dfa_94a0202f0fec
is: SBO:0000252
is encoded by: hsa:2805
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P17174
initial amount: NaN
constant: false
name: GOT1
type: Species

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

metaR BTNDe
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110013#
name: biotinidase (biotin), extracellular
is: SBO:0000176
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
product: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
reversible: false

metaM pchol hs c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:16110
name: Phosphatidylcholine
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaM CE1926 e
is: SBO:0000247
initial amount: NaN
name: gama-carboxyethyl-hydroxychroman
is: CHEBI:15748
initial concentration: 1.0
is: HMDB00127
type: Species
boundary condition: false
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
constant: false
has only substance units: false

metaM orot c
name: Orotate
type: Species
is: C00295
boundary condition: false
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:30839
is: HMDB00226

metaR RE0577C
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0577
reactant: MODEL1310110013#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
kinetic law: MODEL1310110013#

metaM ppi e
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
initial concentration: 1.0
name: Diphosphate
is: SBO:0000247
is: CHEBI:33019
type: Species
boundary condition: false
is: C00013
initial amount: NaN
constant: false

metaR INSTt2r
reversible: true
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
modifier: MODEL1310110013#
is: SBO:0000185
name: inositol transport in via proton symport
is described by: ECO:0000269

W3 CDTF: Thu Aug 30 19:58:41 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110013#_33576cab_ccbd_43a7_808a_0b8036b0e247
name: _AV717590_1_c
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:AV717590
initial amount: NaN
boundary condition: true
has only substance units: false

metaM hs deg21 l
boundary condition: false
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
notes: FORMULA: C37H55NO38S2 CHARGE: -4
initial concentration: 1.0
is: HMDB00127
constant: false
type: Species
has only substance units: false
is: CHEBI:15748
initial amount: NaN

metaM galgluside hs g
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
initial concentration: 1.0
is: CHEBI:58223
name: galactosyl glucosyl ceramide
has only substance units: false
is: C00015
is: HMDB00295
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR CYSO
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.20
reversible: false
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
name: cysteine oxidase
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_217e9570_d6a2_4bd7_a620_bdbd920131f7
boundary condition: true
is: Q4J699
constant: false
is encoded by: hsa:491
is: SBO:0000252
name: ATP2B2
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaR RE3347C
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
fast: false
name: RE3347
kinetic law: MODEL1310110013#
type: Reaction

metaR CSPG Etly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: false
product: MODEL1310110013#
name: chondroitin sulfate E transport, extracellular to lysosome
is: SBO:0000185
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR ICDHy
name: isocitrate dehydrogenase (NADP)
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
product: MODEL1310110013#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42

metaR FAOXC204C205x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110013#_f8f6fe2a_0692_4d86_a568_23d6f77ea181
is encoded by: hsa:10841
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
name: FTCD
boundary condition: true

metaM ser D e
initial amount: NaN
is: SBO:0000247
is: CHEBI:16523
type: Species
boundary condition: false
name: D-serine
constant: false
has only substance units: false
is: HMDB03406
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110013#_4d5413c4_0384_4273_a28d_c2685959a722
name: FUT3
is encoded by: hsa:2525
type: Species
initial amount: NaN
is: P21217
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR r0130
modifier: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
reversible: true
is described by: ECO:0000000
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_74c8772f_8f0f_4359_892b_afe6c7ee0928
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6818
initial amount: NaN
constant: false
is: P50224
has only substance units: false
type: Species
name: SULT1A3
initial concentration: NaN

metaR r0497
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is described by: ECO:0000000
modifier: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.2

http://identifiers.org/biomodels.db/MODEL1310110013#_0752c8d1_dab6_4fa9_ba62_05df59d96671
is: Q5JPA4
is: SBO:0000252
is encoded by: hsa:53919
type: Species
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
name: SLCO1C1

metaM ppi c
is: CHEBI:0
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00250
name: Diphosphate
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3
is: C00013

metaM arachdcoa r
is: HMDB06523
is: SBO:0000247
is: CHEBI:57368
has only substance units: false
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
initial concentration: 1.0
name: arachidonoyl-CoA(4-)
boundary condition: false
initial amount: NaN

metaR SUCCt2m
modifier: MODEL1310110013#
name: succinate transport, mitochondrial
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_f828bea3_e061_4a4b_b58c_29cd75820d0a
is: O95139
initial amount: NaN
is: SBO:0000252
name: NDUFB6
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4712
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_afa0ea64_9650_48a8_8e56_10cb33653863
name: SCP2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6342
is: C9JC79
initial amount: NaN

metaM maltpt e
is: C02052
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: HMDB01296
boundary condition: false
initial concentration: 1.0
name: maltopentaose
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_032052d7_77ae_404d_846e_948c34645593
boundary condition: true
name: LDHD
initial amount: NaN
is: Q86WU2
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:197257
is: SBO:0000252

metaM CE5119 m
constant: false
is: CHEBI:57923
is: SBO:0000247
name: trans-3-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false

metaM hexccoa c
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: Hexacosanoyl-CoA (n-C26:0CoA)
is: HMDB06459
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_d18427f7_ab46_4c0a_a50a_86fe103ea258
initial concentration: NaN
is: P22413
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: ENPP1
has only substance units: false
is encoded by: hsa:5167
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_d418fedc_ff1d_4d39_8962_0cc1a7dbb4b8
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:55753
constant: false
name: OGDHL
is: Q9ULD0
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR FAOXC164C163x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaM thp2c x
has only substance units: false
is: HMDB12130
boundary condition: false
initial concentration: 1.0
name: 1-piperideine-6-carboxylate
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:16987
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450

metaM hs deg14 l
boundary condition: false
name: heparan sulfate, degradation product 14
has only substance units: false
constant: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
is: SBO:0000247
is: HMDB00127
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15748

metaR H2Otg
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
name: H2O transport, Golgi apparatus
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_6d36e69f_ca06_4999_9bbf_7e72a6dafd22
boundary condition: true
name: PDE4A
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:5141
is: P27815
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ee1cd216_9d3a_4b58_a476_5d6a3be1d4e1
name: ENTPD3
constant: false
has only substance units: false
is: O75355
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:956
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_64457ee4_2839_4bec_a8ce_fd3a4b70ba7c
has only substance units: false
name: LDHAL6B
type: Species
is encoded by: hsa:92483
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9BYZ2
constant: false
initial amount: NaN

metaR FAOXC10C8x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR NTD6
reversible: false
type: Reaction
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134
fast: false
name: 5'-nucleotidase (dAMP)
reactant: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_216ab525_120d_473a_9120_dd192cc714f6
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: IK
constant: false
is encoded by: hsa:3550
is: Q13123
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_1ccfd310_3342_49de_a729_d35d59a8e9ac
is: SBO:0000252
name: ADH1A
is encoded by: hsa:124
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P07327

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM dhf m
type: Species
has only substance units: false
initial concentration: 1.0
name: dihydrofolate(2-)
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056
is: CHEBI:57451

metaR SARCStex
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
reversible: false
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
name: Sarcosine transport (extracellular to cytosol)

http://identifiers.org/biomodels.db/MODEL1310110013#_546759ba_0ef5_40c4_84a0_3084567e6d4c
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: PIGP
is encoded by: hsa:51227
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_a9612c74_d3ba_4952_8fdc_239a316f5db3
is encoded by: hsa:NM 013421
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: _NM_013421_1_e
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_c071c8be_3ebf_435d_bc23_e62e3a08658a
is encoded by: hsa:2936
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: P00390
name: GSR
boundary condition: true
is: SBO:0000252

metaR LACLt
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: Lactate transport
reversible: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
type: Reaction
fast: false
is described by: ECO:0000134
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_62293119_784d_446e_97fc_2f0bef9ca319
constant: false
is: P23743
is encoded by: hsa:1606
type: Species
initial amount: NaN
name: DGKA
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_a7e562b7_5210_4532_971d_980ae5bf2efa
is encoded by: hsa:50484
initial concentration: NaN
name: RRM2B
has only substance units: false
initial amount: NaN
is: Q7LG56
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaM hxan e
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
name: hypoxanthine
is: HMDB00157
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
is: CHEBI:17368
initial amount: NaN
is: SBO:0000247

metaM ser D c
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
name: D-serine
is: HMDB03406
boundary condition: false
is: CHEBI:16523
is: SBO:0000247

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_15b3a568_9d82_4e8c_a994_65cb987f31c1
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q99624
name: SLC38A3
is encoded by: hsa:10991

http://identifiers.org/biomodels.db/MODEL1310110013#_20e615a0_353b_49d1_af9c_81ce10931d45
initial concentration: NaN
constant: false
is encoded by: hsa:204
type: Species
initial amount: NaN
boundary condition: true
is: P54819
has only substance units: false
name: AK2
is: SBO:0000252

metaM ksi deg34 l
type: Species
is: CHEBI:57455
initial amount: NaN
name: keratan sulfate I, degradation product 34
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C76H126N5O59S1 CHARGE: -1
constant: false
is: HMDB01354
initial concentration: 1.0

metaR AMPDA
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: Adenosine monophosphate deaminase
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
is described by: ECO:0000269
product: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.5.4.6
type: Reaction
is: SBO:0000176
fast: false
reversible: false

metaM crm hs r
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
initial concentration: 1.0
initial amount: NaN
name: N-acylsphingosine
has only substance units: false
is: CHEBI:52639
constant: false

metaR GluForTx
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.5
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is: SBO:0000176
reversible: false
name: Glutamate formimidoyltransferase
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaR r0268
is version of: http://identifiers.org/ec-code/3.1.3.1
reactant: MODEL1310110013#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
kinetic law: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
reversible: true
modifier: MODEL1310110013#
fast: false
is described by: ECO:0000000

metaR r1960
product: MODEL1310110013#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaM hxan c
initial amount: NaN
name: Hypoxanthine
initial concentration: 1.0
constant: false
is: C00262
is: SBO:0000247
type: Species
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: CHEBI:17368
boundary condition: false
has only substance units: false
is: HMDB00157

metaM 3hmp m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:11805
name: 3-hydroxy-2-methylpropanoate
constant: false
has only substance units: false
is: HMDB00023
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
type: Species
boundary condition: false

metaM nad c
is: C00003
initial amount: NaN
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
initial concentration: 1.0
is: CHEBI:57540
constant: false
type: Species
boundary condition: false
is: SBO:0000247
name: Nicotinamide adenine dinucleotide
has only substance units: false

metaR r0267
modifier: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.5.1.9
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2

metaR C4x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_87245ec5_eac7_4a84_ba94_38afab32bc3e
boundary condition: true
type: Species
is encoded by: hsa:314
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: AOC2
has only substance units: false

metaR r2320
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
is: SBO:0000185

metaM glyc R c
is: CHEBI:16659
is: SBO:0000247
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00139
type: Species
initial amount: NaN
name: D-glycerate

metaR FAOXC225C226x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR PYK
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: pyruvate kinase
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
fast: false
is: SBO:0000176
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_c359c287_f1ca_4322_b3bc_25ab515f2226
constant: false
name: _AI191472_1_c
initial concentration: NaN
is encoded by: hsa:AI191472
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_45363de1_7e63_4e81_9910_292dcc861a79
is: Q8WUM9
initial concentration: NaN
constant: false
name: SLC20A1
has only substance units: false
type: Species
is encoded by: hsa:6574
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR CYTK13n
modifier: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP),nuclear
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#

metaM crm hs l
is: CHEBI:52639
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
name: N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110013#_1f9fe310_5401_4c81_8fcc_d8826e394f6d
constant: false
initial concentration: NaN
name: ACOX1
type: Species
is: SBO:0000252
has only substance units: false
is: Q15067
initial amount: NaN
is encoded by: hsa:51
boundary condition: true

metaR ACGAM6PSi
is described by: ECO:0000304
kinetic law: MODEL1310110013#
fast: false
name: N-acetylglucosamine-6-phosphate synthase
modifier: MODEL1310110013#
reversible: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.4
type: Reaction
is: SBO:0000176
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD

metaR S6TASE17ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
modifier: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_5e109a6c_4f92_48c8_b1c0_99e65818d8d5
constant: false
is encoded by: hsa:18
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ABAT
is: SBO:0000252
is: P80404
type: Species
boundary condition: true

metaM g6p c
is: SBO:0000247
is: CHEBI:61548
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: D-Glucose 6-phosphate
type: Species
is: C00092
constant: false
boundary condition: false
is: HMDB01401
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092

http://identifiers.org/biomodels.db/MODEL1310110013#_310514a1_f688_442f_b54f_1b1d1a5f318f
is: SBO:0000252
has only substance units: false
constant: false
type: Species
is: Q96EK6
is encoded by: hsa:64841
initial concentration: NaN
name: GNPNAT1
initial amount: NaN
boundary condition: true

metaR PI5P4K
fast: false
type: Reaction
reversible: false
name: phosphatidylinositol-5-phosphate 4-kinase
notes: GENE_ASSOCIATION: (5297.1) or (55361.1) or (5298.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.149 Confidence Level: 4 AUTHORS: PMID:10358929,PMID:9211928,PMID:9367159 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.67
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_4143d1f0_3640_4c60_9de0_41d8c6c51bf0
is: SBO:0000252
initial amount: NaN
name: ALDH7A1
initial concentration: NaN
is: E7EPT3
is encoded by: hsa:501
constant: false
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_850b2ece_2ae7_4607_a265_6c6ea8fefeeb
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:4711
initial concentration: NaN
name: NDUFB5
is: O43674
constant: false

metaR TCHOLAte
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport

metaM HC02203 c
constant: false
boundary condition: false
name: prostaglandin-a2
type: Species
is: CHEBI:27820
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR SARCStm
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reversible: false
name: Sarcosine transport (mitochondrial)
kinetic law: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_e785a17a_b689_41d4_9f44_1f60f0d0bde4
is: P19440
initial amount: NaN
name: GGT1
is: SBO:0000252
is encoded by: hsa:2678
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_a06e5fe6_b71d_49c5_bcec_34fd98077a63
type: Species
name: HADHA
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3030
is: E9KL44
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_bd76ac7c_1777_4efb_b762_9e627b8404b7
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI631997
name: _AI631997_1_m
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_290b9cce_c764_446e_98f0_8a72e2275c3d
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: PIK3R1
has only substance units: false
is: P27986
is: SBO:0000252
is encoded by: hsa:5295

metaR ATPS4m
is: SBO:0000185
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.14
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.6.1.14
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.6.4.6
name: ATP synthase (four protons for one ATP)
modifier: MODEL1310110013#
fast: false

metaM 4ppcys c
is: C04352
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
has only substance units: false
is: HMDB01117
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:59458
initial concentration: 1.0

metaR FACOAL240
is: SBO:0000176
name: fatty-acid--CoA ligase
product: MODEL1310110013#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110013#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_0a971731_3809_4c53_ae4e_0e568ffa3ae3
name: PFKL
boundary condition: true
is: SBO:0000252
is: Q7L2M7
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5211
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_22cddcc4_b267_4a12_a1a3_64b8b5a7dc1a
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10317
type: Species
constant: false
initial concentration: NaN
name: B3GALT5
boundary condition: true
initial amount: NaN

metaR FACOAL241
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110013#
fast: false
name: fatty-acid--CoA ligase
type: Reaction
modifier: MODEL1310110013#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_bcbde84f_1d43_40cf_ba98_ecc8f509d6a9
is: O60503
constant: false
type: Species
initial concentration: NaN
name: ADCY9
is encoded by: hsa:115
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r2324
is: SBO:0000185
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM lgnccoa c
boundary condition: false
is: HMDB06526
type: Species
name: lignocericyl coenzyme A
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
initial concentration: 1.0
is: SBO:0000247

metaM hs deg6 l
boundary condition: false
name: heparan sulfate, degradation product 6
is: SBO:0000247
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB06210
type: Species

metaR S4TASE3ly
modifier: MODEL1310110013#
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.12
product: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
fast: false
reversible: true

metaR DNDPt36m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: dGDP transport via dCDP antiport
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reversible: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_6b7b687b_0b6d_4769_979c_cd99bcf758b7
constant: false
type: Species
is: SBO:0000252
name: ACSL3
initial concentration: NaN
is: O95573
is encoded by: hsa:2181
has only substance units: false
initial amount: NaN
boundary condition: true

metaR CSEPASEly
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
is: SBO:0000176

metaR PSt3
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true
name: phosphatidylserine transport
product: MODEL1310110013#
fast: false

metaR FBA2
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#
fast: false
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110013#
reactant: MODEL1310110013#

metaM ivcoa m
initial amount: NaN
is: HMDB01113
type: Species
constant: false
boundary condition: false
name: Isovaleryl-CoA
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: CHEBI:57345

metaR PGI
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
name: glucose-6-phosphate isomerase
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/5.3.1.9
reversible: true
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_719cc963_d56c_4f34_96ec_7f7e154e4f91
type: Species
is: SBO:0000252
is: O95427
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: PIGN
is encoded by: hsa:23556
has only substance units: false

metaR r2323
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaR NACHEX10ly
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false

metaR OIVD2m
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.168
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
modifier: MODEL1310110013#
type: Reaction
is described by: ECO:0000269
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
product: MODEL1310110013#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.4.4

http://identifiers.org/biomodels.db/MODEL1310110013#_08a17458_6c4b_4e8a_82f9_933079b2d9c2
is encoded by: hsa:8897
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: MTMR3

metaM crm hs g
boundary condition: false
has only substance units: false
is: SBO:0000247
name: N-acylsphingosine
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_b6bc2dec_1487_4b6f_87ff_b392a91f763e
name: PDE7A
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q13946
is encoded by: hsa:5150

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

metaR C160CPT2
type: Reaction
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
product: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
name: C160 transport into the mitochondria
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV

metaR r2322
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

http://identifiers.org/biomodels.db/MODEL1310110013#_f88ee385_e16b_4f40_a000_6f7f017b8537
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: O95477
is: SBO:0000252
name: ABCA1
has only substance units: false
is encoded by: hsa:19

metaR VACCt
kinetic law: MODEL1310110013#
name: fatty acid transport via diffusion
reactant: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reversible: true
type: Reaction

metaM acetol c
name: hydroxyacetone
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
initial amount: NaN
constant: false
is: CHEBI:27957
is: HMDB06961
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM cbasp e
has only substance units: false
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: CHEBI:32814
is: SBO:0000247
is: C00438
type: Species
name: N-Carbamoyl-L-aspartate
is: HMDB00828
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR FBA4
product: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
reactant: MODEL1310110013#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
kinetic law: MODEL1310110013#
is: SBO:0000176
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase

http://identifiers.org/biomodels.db/MODEL1310110013#_f2b5baba_3d00_4f5c_b854_bdd448a38363
has only substance units: false
is encoded by: hsa:2984
is: P25092
initial amount: NaN
name: GUCY2C
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR AK2LGCHOLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
reversible: true
product: MODEL1310110013#
is described by: ECO:0000269
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
fast: false

metaM 13dpg c
is: HMDB01270
constant: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/3535
is: CHEBI:57604
has only substance units: false
name: 3-Phospho-D-glyceroyl phosphate
initial concentration: 1.0
initial amount: NaN
is: C00236
type: Species

metaR PGK
is version of: http://identifiers.org/ec-code/2.7.2.3
name: phosphoglycerate kinase
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#

metaR r2321
reactant: MODEL1310110013#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_bac07f4c_27e9_462e_835f_233e3f488f75
is encoded by: hsa:5464
is: Q15181
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: PPA1
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR CYTK10
kinetic law: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110013#
is: SBO:0000176
fast: false
name: cytidylate kinase (CMP,dGTP)
reactant: MODEL1310110013#

metaR DNDPt25m
type: Reaction
name: dTDP transport via dCDP antiport
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#

metaR r0587
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
modifier: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_ddfa236f_a95b_45bb_ae1b_ab55a02490c3
is encoded by: hsa:51268
is: Q9P0Z9
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: PIPOX
is: SBO:0000252

metaR RE1796M
reversible: true
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.145
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110013#
name: RE1796

http://identifiers.org/biomodels.db/MODEL1310110013#_52a63526_a278_4bec_99c4_8cc2dd94bc37
name: PLCB4
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: E2QRH8
has only substance units: false
is encoded by: hsa:5332
initial amount: NaN
is: SBO:0000252

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_421f67a8_0470_40e8_b7ea_8243e387224d
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: ALDH1A3
is: P47895
is encoded by: hsa:220
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_89aef7ac_3dda_44b2_ad49_099eefe64634
is: Q76EJ3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:11046
constant: false
boundary condition: true
initial amount: NaN
name: SLC35D2
initial concentration: NaN
type: Species

metaR r0139
kinetic law: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.2.2
reversible: true
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_4cf8ee79_5cc3_4788_bfa6_d1cbc43f6615
name: NDUFA5
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:4698
has only substance units: false
is: Q16718
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r0698
is version of: http://identifiers.org/ec-code/3.1.2.27
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
reversible: true
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176

metaM 2dr1p c
is: HMDB01351
constant: false
is: CHEBI:58576
initial amount: NaN
name: 2-Deoxy-D-ribose 1-phosphate
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: C00672

metaM nad r
is: HMDB00902
is: CHEBI:57540
boundary condition: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
has only substance units: false
name: NAD(1-)
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species

metaR CSAPASEly
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
reversible: false
is: SBO:0000176
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)

metaM hs deg8 l
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
name: heparan sulfate, degradation product 8
initial amount: NaN
is: HMDB00127
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15748

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_54cf9b69_f893_46a5_a22b_aed96a08b5c0
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: P28332
initial concentration: NaN
name: ADH6
has only substance units: false
is encoded by: hsa:130
type: Species

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM but e
is: HMDB00039
type: Species
is: SBO:0000247
name: butyrate
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_14c54b45_45c4_41fe_ac49_db20d231cb2c
name: _2544_1_c
is: SBO:0000252
is encoded by: hsa:2544
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN

metaR CYTK11
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,dGTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110013#_dee07402_9b25_4126_9341_e442a87705cf
initial concentration: NaN
boundary condition: true
name: _AF116616_1_m
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:AF116616
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7f215b6a_c779_44ae_bdbc_f50601f897be
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: _AL525798_1_c
boundary condition: true
is encoded by: hsa:AL525798
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_d151e801_0d84_4e9e_80c4_f40cbe7f4994
is: SBO:0000252
initial amount: NaN
name: ECI2
constant: false
type: Species
is: O75521
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10455
has only substance units: false

metaR r2328
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110013#
type: Reaction
reversible: true

metaR RE2954C
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
name: RE2954
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:

metaR DOLPMT4 Ler
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110013#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
is described by: ECO:0000000
reversible: false
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_bba985d9_7960_4cd8_ae57_a8cd81452eb4
name: NDUFB2
boundary condition: true
is: H7C5B8
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:4708
constant: false

metaR NDP8ex
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is: SBO:0000176
name: nucleoside-diphosphatase (UTP), extracellular
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR RE3627M
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE3627
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_2f97e909_4dd2_4bae_aa85_f5ae3b1949f0
is encoded by: hsa:8876
is: SBO:0000297
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
name: VNN3:VNN2:VNN1
has only substance units: false
has part: O95497
is encoded by: hsa:8875
is encoded by: hsa:55350
has part: A8K7W0
type: Species

metaR ALADGLNexR
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
reversible: true
name: L-alanine/glutamine reversible exchange
is: SBO:0000185
modifier: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#

metaR CYTK12
type: Reaction
name: cytidylate kinase (dCMP,dCTP)
kinetic law: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is: SBO:0000176

metaM ala L m
type: Species
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: SBO:0000247
constant: false
is: CHEBI:16977
initial amount: NaN
is: HMDB00161
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_ce546799_5681_4f3e_a024_4d8875fb043c
name: MTMR3
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:8897
constant: false

metaR CRNtuNa
type: Reaction
is described by: ECO:0000269
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
name: L-carnitine inward transport by Na+ symport

metaM crm hs c
name: N-acylsphingosine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
initial amount: NaN
has only substance units: false
is: CHEBI:52639
constant: false
type: Species
is: SBO:0000247

metaR r2327
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110013#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110013#
is: SBO:0000185

metaM ksi deg3 l
initial concentration: 1.0
constant: false
is: HMDB00573
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:30825
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
initial amount: NaN
has only substance units: false
name: keratan sulfate I, degradation product 3

metaM 3octdectecoa m
name: 3,6,9,12-octadecatetraenoylcoa
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaR r1850
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
product: MODEL1310110013#

metaR RE1796R
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110013#
name: RE1796
reversible: true
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.145

metaR DM ethamp r
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM but c
name: butyrate
type: Species
has only substance units: false
is: HMDB00039
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
initial concentration: 1.0
constant: false

metaM 3hpcoa m
initial amount: NaN
is: HMDB06807
initial concentration: 1.0
is: CHEBI:58528
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
constant: false
name: 3-hydroxypropanoyl-CoA(4-)

metaR CYTK13
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110013#
type: Reaction
reversible: true
name: cytidylate kinase (dCMP,dATP)
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176

metaR MALSO4tm
product: MODEL1310110013#
modifier: MODEL1310110013#
name: Malate:sulfate antiport, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000269

metaM CE0849 m
constant: false
name: cis,cis-palmito-7,10-dienoyl-CoA
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:57795
is: SBO:0000247
initial concentration: 1.0

metaR r2326
type: Reaction
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR GTHP
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.11.1.9
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.15
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
name: glutathione peroxidase
is described by: ECO:0000134
type: Reaction
fast: false
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.11.1.12

metaM nad m
type: Species
is: HMDB00902
is: C00003
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57540
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_10473b79_f596_4577_9fef_eb6942ec46fa
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: DHCR24
boundary condition: true
is encoded by: hsa:1718
initial amount: NaN
type: Species
is: Q15392
constant: false

metaM xol7ah c
is: HMDB06892
constant: false
is: CHEBI:2290
is: SBO:0000247
type: Species
name: 7alpha-hydroxy-5beta-cholestan-3-one
has only substance units: false
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
initial concentration: 1.0
initial amount: NaN

metaR r0377
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110013#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000000

metaM sebcoa x
type: Species
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
constant: false
name: sebacoylcoa
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966

metaR KAS8
name: b-ketoacyl synthetase (palmitate, n-C16:0)
product: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
reversible: false
kinetic law: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:

metaR FAOXC225C226m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaR r2325
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaR CYTK14
type: Reaction
reversible: true
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110013#
is: SBO:0000176
name: cytidylate kinase (dCMP,UTP)
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_df1693c0_5ef9_45ba_a8fc_7165fa35ffa9
is: A0PJH2
is encoded by: hsa:10476
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: ATP5H
type: Species
initial concentration: NaN
initial amount: NaN

metaM pap c
type: Species
name: adenosine 3',5'-bismonophosphate(4-)
is: SBO:0000247
is: CHEBI:58343
boundary condition: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: HMDB00061
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR GTHO
is version of: http://identifiers.org/ec-code/1.8.1.7
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
is described by: ECO:0000254
type: Reaction
reversible: false
name: glutathione oxidoreductase
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2

metaM docosahexcoa m
constant: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 3,7,10,13,16,19-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4

metaM crm hs e
initial amount: NaN
type: Species
name: N-acylsphingosine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:52639
constant: false
boundary condition: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false

metaR DINt
is: SBO:0000185
name: deoxyinosine transport via diffusion
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110013#
product: MODEL1310110013#

metaR GALASE12ly
modifier: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reversible: false
fast: false
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM glyc R m
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: SBO:0000247
has only substance units: false
is: HMDB00139
initial amount: NaN
type: Species
boundary condition: false
name: D-glycerate
is: CHEBI:16659

metaR FAOXC225x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_bb957d37_cc88_45cb_8c13_310a1b9fd3c1
name: SLC33A1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9197
has only substance units: false
is: SBO:0000252
constant: false
is: O00400
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_a3777f0e_9786_4f58_9b44_ccf5560e7b49
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is: P09104
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ENO2
is encoded by: hsa:2026

http://identifiers.org/biomodels.db/MODEL1310110013#_4f5b84a5_904b_40ce_bc36_15188af39e27
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1962
name: EHHADH
is: SBO:0000252
is: Q9NY65

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM 3aib e
is: HMDB02166
boundary condition: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
has only substance units: false
initial amount: NaN
constant: false
name: (S)-3-aminoisobutyric acid
is: SBO:0000247
is: CHEBI:33094
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_59c7ccbb_0344_4ca1_9280_3bcc1d4660ba
constant: false
is encoded by: hsa:8833
has only substance units: false
name: GMPS
boundary condition: true
initial amount: NaN
is: P49915
type: Species
is: SBO:0000252
initial concentration: NaN

metaM pyr m
has only substance units: false
name: pyruvate
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:15361
is: HMDB00243
is: C00022
type: Species
is: http://identifiers.org/pubchem.compound/3324
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
boundary condition: false
is: SBO:0000247

metaR r2319
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110013#
fast: false

metaR LYStip
fast: false
name: L-lysine transport, peroxisomal (irreversible)
type: Reaction
reversible: false
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM

metaR r0480
reversible: true
is described by: ECO:0000000
is: SBO:0000176
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR r0145
modifier: MODEL1310110013#
product: MODEL1310110013#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/1.8.3.1

http://identifiers.org/biomodels.db/MODEL1310110013#_bc060001_7840_4672_b6fa_4b449e4932d1
is encoded by: hsa:5294
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: HCST:PIK3CG
is: SBO:0000297
has part: P48736
type: Species
has part: Q9UBK5
is encoded by: hsa:10870

metaR r2195
product: MODEL1310110013#
modifier: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
fast: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_81d402d3_12bb_4101_ba33_32acd3f41680
boundary condition: true
name: RPIA
has only substance units: false
initial concentration: NaN
is: P49247
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:22934
type: Species

metaR r1631
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CYTD
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
reactant: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.5
is: SBO:0000176
name: cytidine deaminase
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_3e9c0f8f_e870_438e_8134_4a1c82edaf9e
has only substance units: false
is encoded by: hsa:2523
is: SBO:0000252
initial concentration: NaN
name: FUT1
boundary condition: true
initial amount: NaN
is: Q6IZA2
constant: false
type: Species

metaR HMGCOAtm
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_26a71748_268f_4b5a_8395_4e5c5035d351
is: SBO:0000252
type: Species
is encoded by: hsa:2542
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: SLC37A4
boundary condition: true
is: A8K0S7

metaR MI145PK
is: SBO:0000176
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
name: inositol-1,4,5-trisphosphate 3-kinase
is described by: ECO:0000269
modifier: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.127
type: Reaction
kinetic law: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_8bf53d06_a3cb_4acc_a446_22dfddf48a62
is: P05496
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ATP5G1
initial amount: NaN
is encoded by: hsa:516
type: Species

metaM coa e
initial concentration: 1.0
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
has only substance units: false
is: HMDB01423
is: C00010
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR S6TASE14ly
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110013#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110013#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
is: SBO:0000176
product: MODEL1310110013#

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_453f0cb0_8fe6_428b_a47f_e9f1d3f43bf9
is encoded by: hsa:5211
has only substance units: false
type: Species
boundary condition: true
name: PFKL:PFKP
constant: false
initial concentration: NaN
has part: Q7L2M7
initial amount: NaN
is: SBO:0000297

metaM msa m
is: CHEBI:33190
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
name: 3-oxopropanoate
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
initial amount: NaN
is: HMDB11111
type: Species

metaR ACGALtly
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
name: N-acetyl-galactosamine lysosomal efflux
fast: false

metaR r0594
is: SBO:0000176
modifier: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
kinetic law: MODEL1310110013#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
fast: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
reversible: true

metaR NDPK1m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is: SBO:0000176
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110013#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
reversible: true
modifier: MODEL1310110013#

metaR ADEt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
type: Reaction
name: adenine reversible transport, cytosol
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
fast: false
product: MODEL1310110013#
modifier: MODEL1310110013#

metaR r1630
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#

metaM nrpphrsf c
type: Species
name: Sulfate derivative of norepinephrine
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: HMDB02062
is: http://identifiers.org/pubchem.compound/123747

metaR r2196
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110013#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110013#_01d3b345_5883_4182_b2a5_a4c878202f98
boundary condition: true
initial amount: NaN
is encoded by: hsa:160287
type: Species
has only substance units: false
name: LDHAL6A
is: SBO:0000252
is: Q6ZMR3
constant: false
initial concentration: NaN

metaM bhb e
initial concentration: 1.0
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: HMDB00011
name: (R)-3-hydroxybutyrate

metaR r2317
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_c8a39a65_af14_40fb_9083_7de1b4d5ab23
boundary condition: true
has only substance units: false
is: P19404
type: Species
initial amount: NaN
constant: false
name: NDUFV2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4729

http://identifiers.org/biomodels.db/MODEL1310110013#_255dcd35_3b42_41c2_a3c1_4b0915200343
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5152
constant: false
boundary condition: true
name: PDE9A

metaM ppi x
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
has only substance units: false
type: Species
is: HMDB00250
is: SBO:0000247
name: Diphosphate
initial concentration: 1.0
is: C00013

metaR r2197
fast: false
is: SBO:0000185
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_2837da6e_01f1_4a21_a61d_6f33c76afd0a
constant: false
name: NDUFS1
initial amount: NaN
initial concentration: NaN
is: P28331
is encoded by: hsa:4719
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

metaR r0591
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
modifier: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110013#
fast: false
type: Reaction
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM 3oddcoa m
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: CHEBI:27868
has only substance units: false
is: SBO:0000247
is: HMDB03937
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
name: 3-Oxododecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110013#_f6fd8f16_1763_4371_8dba_ea93fe2c4960
constant: false
type: Species
is: A8DPS7
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5049
is: SBO:0000252
boundary condition: true
name: PAFAH1B2

http://identifiers.org/biomodels.db/MODEL1310110013#_662c2b6f_963b_4271_9e30_6b56395c4919
has only substance units: false
is encoded by: hsa:55350
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: VNN3:VNN2:VNN1
type: Species
constant: false
is: SBO:0000297

metaM CE5236 c
is: CHEBI:28002
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
name: O2'-4a-cyclic-tetrahydrobiopterin
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB03952
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236

metaM nrpphrsf e
is: http://identifiers.org/pubchem.compound/123747
constant: false
type: Species
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial amount: NaN
name: Sulfate derivative of norepinephrine
is: SBO:0000247
boundary condition: false
is: HMDB02062
initial concentration: 1.0
has only substance units: false

metaM eaflatoxin c
is: CHEBI:30725
is: HMDB06558
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C17H12O7 CHARGE: 0 INCHI: InChI=1S/C17H12O7/c1-20-7-4-8-11(12-14-17(23-14)24-16(12)21-8)13-10(7)5-2-3-6(18)9(5)15(19)22-13/h4,12,14,16-17H,2-3H2,1H3/t12-,14-,16+,17+/m1/s1
constant: false
name: aflatoxin B1 exo-8,9-epoxide
type: Species
boundary condition: false

metaR DGK2m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
fast: false
reactant: MODEL1310110013#
is described by: ECO:0000000

metaR r2318
kinetic law: MODEL1310110013#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaM coa c
is: CHEBI:3312
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
initial amount: NaN
is: C00010
type: Species
is: HMDB01423
boundary condition: false
constant: false
is: SBO:0000247
name: Coenzyme A
initial concentration: 1.0
has only substance units: false

metaR r2198
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM ksii core4 e
name: keratan sulfate II (core 4-linked)
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00211
is: CHEBI:17268
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
type: Species

metaM e4p c
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:16897
is: HMDB01321
is: C00279
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial amount: NaN
name: D-Erythrose 4-phosphate

metaM 5adtststerone e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:16330
is: SBO:0000247
has only substance units: false
name: 17beta-hydroxy-5alpha-androstan-3-one
is: HMDB02961
type: Species
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917

metaR FACOAL245 1
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
fast: false
is: SBO:0000176
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM bhb c
name: (R)-3-hydroxybutyrate
boundary condition: false
has only substance units: false
is: CHEBI:10983
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00011

metaR MI145PP
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.56
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
name: inositol-1,4,5-trisphosphate 5-phosphatase
type: Reaction
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.36
is: SBO:0000176
modifier: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false

metaR r1635
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
fast: false

metaR r0149
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110013#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.39
type: Reaction
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_db3053cf_54e3_4f93_ba5b_1003c68bd5c5
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:343
is: O94778
has only substance units: false
constant: false
is: SBO:0000252
name: AQP8
boundary condition: true

metaR UDPGALtg
is described by: ECO:0000269
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
name: UDP-Gal Golgi transport via CMP antiport
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#

metaR RE2269E
type: Reaction
kinetic law: MODEL1310110013#
name: RE2269
reversible: true
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.21.39
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
product: MODEL1310110013#

metaR r2199
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
fast: false

metaM hexccoa x
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
is: HMDB06459
is: SBO:0000247
constant: false
name: Hexacosanoyl-CoA (n-C26:0CoA)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_867182ba_0721_43f3_97b3_25ee7e7b148f
is: SBO:0000252
is encoded by: hsa:51227
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: PIGP
initial amount: NaN

metaM so3 c
is: HMDB00240
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
has only substance units: false
name: Sulfite
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00094
constant: false
type: Species
is: CHEBI:17137
boundary condition: false

metaM c226coa x
initial amount: NaN
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
is: SBO:0000247
is: C16169
constant: false
name: cervonyl coenzyme A
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
type: Species

metaR FACOAL245 2
is described by: ECO:0000269
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
name: fatty-acid--CoA ligase

metaM 2dr5p c
initial amount: NaN
boundary condition: false
is: CHEBI:57651
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: HMDB01031
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
type: Species
has only substance units: false
initial concentration: 1.0

metaM 56dura c
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:15901
name: 5,6-dihydrouracil
is: HMDB00076
has only substance units: false

metaM acmana c
is: HMDB01129
initial amount: NaN
is: CHEBI:17122
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false
initial concentration: 1.0
name: N-acetyl-D-mannosamine

metaR r1634
is described by: ECO:0000000
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction

metaM lnlccrn c
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: HMDB06469
name: Linoleyl carnitine
is: SBO:0000247

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR B3GALTg
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
name: Beta galactosyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.86 Confidence Level: 2 AUTHORS: NOTES:general reaction - no gene association get NJ
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110013#
type: Reaction

metaM dopa e
constant: false
type: Species
is: HMDB00073
is: SBO:0000247
name: dopaminium(1+)
is: CHEBI:59905
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR NACHEX12ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
is: SBO:0000176
fast: false

metaR C204CPT2
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
type: Reaction
name: arachidonic acid transport into the mitochondria
product: MODEL1310110013#
reversible: false

metaR IDOAASE1ly
fast: false
modifier: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: alpha-L-iduronidase, lysosomal
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reversible: false
is described by: ECO:0000000
type: Reaction

metaM dcsptn1crn c
is: SBO:0000247
is: HMDB06321
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_3134dff0_3529_4569_addc_a8933c1d7214
is encoded by: hsa:3628
type: Species
name: INPP1
is: P49441
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r2473
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.4.5
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:12811562 NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110013#

metaR HS2ly
type: Reaction
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: heparan-N-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110013#

metaR ACHtn
kinetic law: MODEL1310110013#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
name: Acetylcholin transport, nuclear trhough pores
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reversible: true

metaM 5adtststerone c
is: CHEBI:16330
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false
has only substance units: false
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR VALTAm
product: MODEL1310110013#
reactant: MODEL1310110013#
name: valine transaminase, mitochondiral
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110013#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_23fdb4dd_c3df_483d_941e_9fefd70a6bd8
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:113
type: Species
name: ADCY7
initial concentration: NaN
is: P51828

metaM 3aib c
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
has only substance units: false
is: HMDB02166
is: SBO:0000247
name: (S)-3-aminoisobutyric acid
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:33094

metaM gcald c
type: Species
is: HMDB03344
name: glycolaldehyde
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:17071
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
initial concentration: 1.0
constant: false

metaM acnamp c
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: N-Acetylneuraminate 9-phosphate
is: CHEBI:27438
initial concentration: 1.0
is: HMDB06268
type: Species
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241

http://identifiers.org/biomodels.db/MODEL1310110013#_51d1e19c_6dfd_4c91_8f42_3b6589e6465e
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5092
constant: false
name: PCBD1
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR r1633
reactant: MODEL1310110013#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110013#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_37fde750_8909_41c2_a24f_e0440806c62c
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC5A9
initial amount: NaN
is: E9PAK4
has only substance units: false
is encoded by: hsa:200010
type: Species

metaR NOt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
fast: false
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110013#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110013#
name: NO transport (diffusion)

metaR S6TASE25ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110013#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
name: galactose-6-sulfate sulfatase, lysosomal
kinetic law: MODEL1310110013#
type: Reaction
fast: false
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: true
reactant: MODEL1310110013#

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR TYROXDAc
fast: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
is described by: ECO:0000269
product: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_e6bcae31_c87b_4273_874a_c130cead8c1b
initial amount: NaN
name: CAD
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is: P27708
is encoded by: hsa:790
boundary condition: true
constant: false

metaM dopa c
name: dopaminium(1+)
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: CHEBI:59905
type: Species
constant: false
initial concentration: 1.0

metaR r0596
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reactant: MODEL1310110013#
reversible: false
product: MODEL1310110013#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_bb69deb3_79de_44aa_8fa4_838ca4c8379f
initial amount: NaN
name: GALNT4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8693
constant: false
is: Q8N4A0
boundary condition: true
has only substance units: false
type: Species

metaR r1632
reversible: true
modifier: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110013#

metaR PEt
reversible: true
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
kinetic law: MODEL1310110013#
type: Reaction
name: phosphatidylethanolamine transport
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM eicostetcrn m
constant: false
initial concentration: 1.0
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
boundary condition: false
is: SBO:0000247
name: Eicosatetranoyl carnitine
has only substance units: false
initial amount: NaN
is: CHEBI:57312
is: HMDB01356
type: Species

metaR IDOAASE4ly
product: MODEL1310110013#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.76
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#

metaM coa g
is: SBO:0000247
boundary condition: false
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
constant: false
is: CHEBI:57287
initial concentration: 1.0
has only substance units: false
is: HMDB01423
initial amount: NaN

metaR DCSPTN1CRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110013#
is: SBO:0000185
fast: false
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
reversible: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_9ac2d630_f23a_45f4_97ee_aecee530c702
is encoded by: hsa:55902
is: Q5QPH3
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ACSS2
boundary condition: true
constant: false
initial amount: NaN

metaR H2Otn
name: H2O transport, nuclear
type: Reaction
reversible: true
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185

metaR r0488
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110013#
fast: false
type: Reaction
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
reversible: true
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reactant: MODEL1310110013#

metaM HC01410 m
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
name: (2E)-Hexenoyl-CoA
boundary condition: false
is: CHEBI:28706
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial concentration: 1.0

metaM CE5853 e
initial amount: NaN
name: alpha-CEHC-glucuronide
constant: false
initial concentration: 1.0
is: CHEBI:57923
is: SBO:0000247
boundary condition: false
notes: FORMULA: C22H29O10 CHARGE: -1 INCHI: InChI=1/C22H30O10/c1-9-10(2)18-12(11(3)14(9)24)5-7-22(4,32-18)8-6-13(23)30-21-17(27)15(25)16(26)19(31-21)20(28)29/h15-17,19,21,24-27H,5-8H2,1-4H3,(H,28,29)/p-1/t15-,16+,17-,19-,21+,22?/m1/s1 EHMN_ABBREVIATION: CE5853
has only substance units: false
type: Species

metaM eicostetcrn c
initial amount: NaN
is: SBO:0000247
is: HMDB01356
is: CHEBI:57312
notes: FORMULA: C27H45NO4 CHARGE: 0 INCHI: InChI=1/C27H46NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,18-19,25H,5-8,11,14,17,20-24H2,1-4H3,(H,29,30)/q+1/p-1
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
name: Eicosatetranoyl carnitine

metaM pyr e
is: CHEBI:15361
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: pyruvate

metaM 3oddcoa x
is: HMDB03937
type: Species
name: 3-Oxododecanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: SBO:0000247
constant: false
is: CHEBI:27868
has only substance units: false
boundary condition: false
initial amount: NaN

metaR r1639
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110013#
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaR PItx
type: Reaction
reactant: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
fast: false
reversible: true
is: SBO:0000185
name: Phosphate transporter, peroxisome
kinetic law: MODEL1310110013#

metaR GLYtm
name: glycine passive transport to mitochondria
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
product: MODEL1310110013#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaR PEAMNO
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is version of: http://identifiers.org/ec-code/1.4.3.4
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.21
name: Phenethylamine oxidase
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
kinetic law: MODEL1310110013#

metaM 3aib m
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:33094
initial concentration: 1.0
is: HMDB02166
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: SBO:0000247
name: (S)-3-aminoisobutyric acid
type: Species

metaM 3octdectecoa x
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: 3,6,9,12-octadecatetraenoylcoa
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
type: Species
initial amount: NaN

metaR MTHFD2
name: methylenetetrahydrofolate dehydrogenase (NAD)
reactant: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
kinetic law: MODEL1310110013#
is described by: ECO:0000134
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaR ALOX5
type: Reaction
is: SBO:0000176
name: Arachidonate 5-lipoxygenase
reactant: MODEL1310110013#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.34
reversible: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe

http://identifiers.org/biomodels.db/MODEL1310110013#_da8c080c_b0e0_4bda_9e4e_89a226b14d04
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2639
name: GCDH
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR HSAT1ly
fast: false
reactant: MODEL1310110013#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000

metaM 3snpyr m
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
type: Species
boundary condition: false
name: 3-Sulfinopyruvate
constant: false
is: SBO:0000247
is: HMDB02332
initial amount: NaN
initial concentration: 1.0
is: CHEBI:1665
has only substance units: false

metaR NRPPHRt4 2 r
reactant: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110013#
is: SBO:0000185
name: Norepinephrine reversible transport in via sodium symport (1:2)
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaM pacald c
has only substance units: false
type: Species
is: HMDB06236
initial concentration: 1.0
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: CHEBI:16424
constant: false
boundary condition: false
name: phenylacetaldehyde
initial amount: NaN
is: SBO:0000247

metaR r1638
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM f26bp c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
constant: false
type: Species
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
is: SBO:0000247
is: HMDB01047
is: CHEBI:58579
has only substance units: false

metaM dhf e
is: SBO:0000247
has only substance units: false
is: CHEBI:57451
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0
constant: false
boundary condition: false
name: dihydrofolate(2-)
initial amount: NaN
type: Species

metaR GGH 10FTHF6GLUe
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
modifier: MODEL1310110013#
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reversible: false
is described by: ECO:0000000

metaM HC01376 m
is: CHEBI:28692
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: S-(2-Methylbutanoyl)-dihydrolipoamide
type: Species
constant: false
has only substance units: false
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118

metaR H2Otp
type: Reaction
reactant: MODEL1310110013#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110013#
name: H2O transport, peroxisomal
is: SBO:0000185
product: MODEL1310110013#

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM udpg r
initial amount: NaN
is: CHEBI:58367
is: HMDB00286
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Species
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaM cs b deg2 l
is: HMDB01354
is: CHEBI:57455
notes: FORMULA: C37H54NO41S3 CHARGE: -5
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
type: Species

metaR CYTDtm
reversible: true
is: SBO:0000185
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
modifier: MODEL1310110013#
fast: false
type: Reaction
is described by: ECO:0000269
name: cytidine facilated transport in mitochondria

metaR CITL
is described by: ECO:0000000
name: Citrate lyase
type: Reaction
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
product: MODEL1310110013#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_1d128707_fedf_455e_acf3_201236f75f28
is: P47895
name: ALDH1A3
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:220
initial amount: NaN
has only substance units: false
constant: false

metaR r1384
name: Guanosine aminohydrolase EC:3.5.4.15
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
product: MODEL1310110013#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000176

metaR r1637
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
type: Reaction

metaM bhb m
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB00011
is: CHEBI:10983
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
boundary condition: false
name: (R)-3-hydroxybutyrate
initial concentration: 1.0

metaM pyr c
is: C00022
has only substance units: false
is: CHEBI:15361
is: HMDB00243
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1
constant: false
name: pyruvate
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
is: SBO:0000247
type: Species

metaM pd3 c
is: HMDB06500
has only substance units: false
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
name: Previtamin D3
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_76a9dc97_179e_4f77_8107_bdb87fe44d73
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:BG035985
name: _BG035985_1_c

metaR KYNAKGAT
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.6.1.7
reversible: false
reactant: MODEL1310110013#
name: L-Kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
product: MODEL1310110013#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_f932a269_d100_4d6c_b080_d20102c4b08f
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:5279
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PIGC

metaR GLYtp
type: Reaction
reversible: true
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
kinetic law: MODEL1310110013#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: glycine passive transport to peroxisome

metaR r1636
reactant: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM dhf c
initial concentration: 1.0
is: CHEBI:57451
constant: false
name: 7,8-Dihydrofolate
is: C00415
is: HMDB01056
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

http://identifiers.org/biomodels.db/MODEL1310110013#_6afc176f_0fa4_45ba_8b8b_d7ee2bea0ba4
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55568
type: Species
boundary condition: true
name: GALNT10
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c9c16382_67c1_434c_810c_733bcd37c5c8
initial concentration: NaN
type: Species
is: P42126
boundary condition: true
is encoded by: hsa:1632
name: ECI1
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_3d310e0b_598e_401c_a1b7_0f1ea985a439
is: SBO:0000252
name: NDUFA2
is: O43678
type: Species
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4695

metaR FAOXC225m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_27a9c00e_6e73_4394_8f4a_cd56ca6472b6
boundary condition: true
name: CA2
is: P00918
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:760
type: Species

metaR r1740
product: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110013#
name: Y+LAT2 Utilized transport
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_08b9da2c_408b_4d76_8e1e_8a8b4ec214b0
initial amount: NaN
initial concentration: NaN
name: _NOS2A_1_c
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:NOS2A

metaM lnlccrn m
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial concentration: 1.0
type: Species
name: Linoleyl carnitine
is: HMDB06469
is: SBO:0000247

metaR BTND1n
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
is: SBO:0000176
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
name: biotinidase (biotin), nuclear
modifier: MODEL1310110013#

metaR PETOHMm hs
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.17
modifier: MODEL1310110013#
is described by: ECO:0000254
reversible: false
name: phosphatidylethanolamine N-methyltransferase
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
product: MODEL1310110013#
is: SBO:0000176
type: Reaction

metaR r0142
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
reversible: false
type: Reaction
product: MODEL1310110013#
modifier: MODEL1310110013#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:

metaM tethex3coa c
is: C16168
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
name: tetracosahexaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205478
has only substance units: false
is: HMDB06243
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_39f9c48e_9ab7_4c26_ac5f_ca8939f8d3e4
has only substance units: false
boundary condition: true
is encoded by: hsa:4731
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: NDUFV3
is: P56181

metaR r0590
is described by: ECO:0000000
modifier: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
reactant: MODEL1310110013#
reversible: false

metaM eaflatoxin e
type: Species
name: aflatoxin B1 exo-8,9-epoxide
initial amount: NaN
notes: FORMULA: C17H12O7 CHARGE: 0 INCHI: InChI=1S/C17H12O7/c1-20-7-4-8-11(12-14-17(23-14)24-16(12)21-8)13-10(7)5-2-3-6(18)9(5)15(19)22-13/h4,12,14,16-17H,2-3H2,1H3/t12-,14-,16+,17+/m1/s1
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:30725
is: HMDB06558
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_01da90c7_5e8e_42fa_a796_848b96807cee
name: GMPR2
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q86T14
is encoded by: hsa:51292

http://identifiers.org/biomodels.db/MODEL1310110013#_f73360a6_e83f_434f_9b58_98f8d5c896ac
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q16635
is encoded by: hsa:6901
initial amount: NaN
name: TAZ

http://identifiers.org/biomodels.db/MODEL1310110013#_dc986067_9f07_453a_9921_2e336faa98d8
type: Species
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is: Q9H3S5
is encoded by: hsa:93183
initial concentration: NaN
name: PIGM
initial amount: NaN

metaR CTPtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110013#
name: CTP diffusion in nucleus
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true
product: MODEL1310110013#
fast: false

metaR r2193
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110013#

metaR FAOXC14C12x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

metaM HC01522 c
type: Species
initial concentration: 1.0
is: CHEBI:28508
is: SBO:0000247
name: Gentisate aldehyde
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585

metaM lys L x
is: CHEBI:32551
initial amount: NaN
type: Species
boundary condition: false
name: L-lysinium(1+)
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
has only substance units: false

metaR FAOXC163GC142m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_fe0c885c_8ce7_402c_bf51_146ef2201865
has part: B4DP47
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:594
boundary condition: true
is: SBO:0000297
name: DBT:DLD:BCKDHA:BCKDHB
has part: P11182
is encoded by: hsa:593
has part: P21953
is encoded by: hsa:1629

metaM CE5236 n
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
type: Species
is: HMDB03952
name: O2'-4a-cyclic-tetrahydrobiopterin
is: CHEBI:28002
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_eabf701d_2403_4e88_9be6_3b99eb5059c1
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: VNN2
boundary condition: true
initial amount: NaN
is encoded by: hsa:8875
is: A8K7W0
type: Species

metaM so3 m
is: CHEBI:17137
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00240
boundary condition: false
type: Species
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial amount: NaN
is: SBO:0000247
name: hydrogensulfite

http://identifiers.org/biomodels.db/MODEL1310110013#_753f7986_e9ff_4cd0_b0da_976015b14904
is encoded by: hsa:272
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: AMPD3
is: B7Z763

metaM s7p c
is: CHEBI:57483
is: C05382
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01068
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
name: Sedoheptulose 7-phosphate

http://identifiers.org/biomodels.db/MODEL1310110013#_49f60a8a_e575_42d8_98cb_cf5b853a18c4
initial amount: NaN
name: IDS
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3423
type: Species
initial concentration: NaN
is: P22304
constant: false
has only substance units: false

metaR r0483
kinetic law: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
product: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reactant: MODEL1310110013#
type: Reaction

metaR H2Otm
is described by: ECO:0000269
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110013#
name: H2O transport, mitochondrial

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_edd6b150_9211_4a82_a863_f2800b9fa5cb
is: SBO:0000252
has only substance units: false
is: O14561
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4706
name: NDUFAB1
boundary condition: true
constant: false

metaR DM dsT antigen g
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaM tettet6coa c
is: C16171
constant: false
initial concentration: 1.0
is: HMDB06516
initial amount: NaN
name: tetracosatetraenoyl coenzyme A
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205481
type: Species
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
boundary condition: false

metaR FAOXC227C226m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_73bd3098_576e_442d_9f8a_d267963841e3
is encoded by: hsa:3284
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: HSD3B2
is: SBO:0000252
is: P26439
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_d80484dc_a161_4d46_bffc_3ea9181de587
initial amount: NaN
is: SBO:0000252
name: SDHC
type: Species
boundary condition: true
is: Q99643
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6391

metaM dtmp e
is: SBO:0000247
is: HMDB01227
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: CHEBI:26999
constant: false
name: dTMP(2-)
has only substance units: false
type: Species
boundary condition: false

metaM HC02216 e
has only substance units: false
is: CHEBI:28922
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false
initial amount: NaN
name: prostaglandin-f2beta
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR CMPACNAtn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110013#
is: SBO:0000185
name: CMP-Sia nuclear export
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: false
fast: false
is described by: ECO:0000000

metaM fad e
initial concentration: 1.0
is: CHEBI:16238
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
boundary condition: false
has only substance units: false
type: Species
is: HMDB01248
is: C00016

metaR AMACRp
modifier: MODEL1310110013#
is described by: ECO:0000269
product: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/5.1.99.4
name: alpha-methylacyl-CoA racemase
fast: false
notes: GENE_ASSOCIATION: (23600.2) or (23600.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid biosynthesis review uniprot NJ
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_9721c9d0_0489_48c1_a529_d9c0e00d449a
is: P54750
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: PDE1A
has only substance units: false
is encoded by: hsa:5136
constant: false

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

metaR ADSK
is version of: http://identifiers.org/ec-code/2.7.1.25
modifier: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110013#
reversible: false
name: adenylyl-sulfate kinase
fast: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#

metaR MDHm
product: MODEL1310110013#
reversible: true
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.37
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
type: Reaction
name: malate dehydrogenase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110013#_489b04ff_8323_4571_a625_ac23ca5ee918
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P14672
name: SLC2A4
is encoded by: hsa:6517
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_59d88802_757e_4daf_9a93_fdde3d880449
is: Q8WXF9
initial amount: NaN
boundary condition: true
is encoded by: hsa:66035
type: Species
is: SBO:0000252
constant: false
name: SLC2A11
initial concentration: NaN
has only substance units: false

metaR GALASE16ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
name: beta-galactosidase, lysosomal

metaM ametam c
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
type: Species
initial amount: NaN
has only substance units: false
is: C01137
boundary condition: false
is: HMDB00988
is: SBO:0000247
constant: false
is: CHEBI:57443
name: S-Adenosylmethioninamine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_266770aa_ceb9_4aea_83a7_21f1ff9a04ab
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: CMPK1
constant: false
is: B2R6S5
is encoded by: hsa:51727

metaM oh1 c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01039
is: C01328

metaR ACNAM9PL
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.56
type: Reaction
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)

http://identifiers.org/biomodels.db/MODEL1310110013#_543bd5af_5b3d_4f4d_a359_f2a0e90d0a21
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:4716
name: NDUFB10
is: A8K761
initial concentration: NaN

metaM dtmp c
is: C00364
is: SBO:0000247
is: HMDB01227
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
name: dTMP
is: CHEBI:26999
constant: false
type: Species
boundary condition: false

metaR UGLT
name: UDPglucose--hexose-1-phosphate uridylyltransferase
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.12
is: SBO:0000176
reversible: true
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
modifier: MODEL1310110013#

metaM HC02216 c
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
has only substance units: false
name: prostaglandin-f2beta
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:28922

metaM fad c
initial concentration: 1.0
is: HMDB01248
is: C00016
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

metaM thcholstoic x
constant: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
boundary condition: false
initial concentration: 1.0
is: CHEBI:18402
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

metaM lys L n
has only substance units: false
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
type: Species
is: CHEBI:32551
initial amount: NaN
is: SBO:0000247
is: HMDB00182
constant: false
initial concentration: 1.0

metaM pydam c
type: Species
name: Pyridoxamine
is: CHEBI:57761
constant: false
boundary condition: false
has only substance units: false
is: C00534
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
initial concentration: 1.0
is: SBO:0000247
is: HMDB01431
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_cf38d10e_8a44_40bd_bc23_5de64c67d09e
is encoded by: hsa:AI915649
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _AI915649_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_52e728ce_ddfc_46c9_af61_1107b34971be
is encoded by: hsa:AA203143
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _AA203143_1_c
initial concentration: NaN
constant: false
has only substance units: false

metaM glcur l
is: HMDB00127
name: D-glucuronate
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
is: CHEBI:15748
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM HC02217 c
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
name: prostaglandin-g2
has only substance units: false
is: CHEBI:27647
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species

metaM CE4876 r
is: SBO:0000247
name: delta12-Prostaglandin J2
initial concentration: 1.0
is: CHEBI:57923
boundary condition: false
initial amount: NaN
constant: false
type: Species
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876

metaR NH4t3r
reversible: true
modifier: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
name: ammonia transport via proton antiport
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
kinetic law: MODEL1310110013#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110013#
fast: false

metaM HC00664 c
type: Species
is: CHEBI:58695
boundary condition: false
name: D-tagatofuranose 6-phosphate(2-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR XYLTD Dr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: xylitol dehydrogenase (D-xyulose-forming)

metaM lys L m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
initial amount: NaN
name: L-lysinium(1+)
is: SBO:0000247
is: HMDB00182
constant: false
is: CHEBI:32551
has only substance units: false

metaM 4izp c
boundary condition: false
is: HMDB01014
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
is: CHEBI:57255
constant: false
type: Species
name: 4-Imidazolone-5-propanoate
has only substance units: false

metaM adp c
is: C00008
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3310
initial concentration: 1.0
has only substance units: false
is: CHEBI:16761
boundary condition: false
constant: false
name: ADP
is: HMDB01341
is: SBO:0000247
type: Species

metaM lgnc c
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
name: lignocerate
type: Species
is: HMDB02003
is: CHEBI:31014
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_070c06cb_8289_4d26_a23a_6ccef2079f0c
initial amount: NaN
is: Q9HBH5
type: Species
is encoded by: hsa:57665
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: RDH14

metaR S6TASE3ly
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110013#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_6c25b7b1_c9d7_40ba_b2ee_8f97b4c0a073
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
name: _AA081045_1_e
initial amount: NaN
is encoded by: hsa:AA081045

metaM o2s c
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
boundary condition: false
type: Species
name: superoxide
has only substance units: false
is: HMDB02168
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM cs e deg3 l
constant: false
is: SBO:0000247
is: HMDB00127
is: CHEBI:15748
notes: FORMULA: C37H53NO44S4 CHARGE: -6
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3

metaR r1995
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DNDPt11m
is: SBO:0000185
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dADP transport via dGDP antiport
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269

metaM dnad c
is: HMDB01179
name: Deamino-NAD+
has only substance units: false
is: CHEBI:18304
is: C00857
is: SBO:0000247
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM ile L e
name: L-isoleucine
initial amount: NaN
constant: false
is: HMDB00172
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
is: CHEBI:17191
has only substance units: false

metaM lgnc e
is: SBO:0000247
constant: false
type: Species
is: CHEBI:31014
has only substance units: false
initial concentration: 1.0
is: HMDB02003
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
initial amount: NaN
boundary condition: false
name: lignocerate

metaR G6Pter
is described by: ECO:0000269
modifier: MODEL1310110013#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true

metaR ANTHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: Transport of anthranilate
is described by: ECO:0000134
reversible: true
fast: false
type: Reaction

metaM 2docopencoa m
name: 2,7,10,13,16-docosapentenoylcoa
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN

metaR r1782
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110013#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110013#

metaM gal l
type: Species
constant: false
initial amount: NaN
is: HMDB00143
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: SBO:0000247
name: D-galactose
has only substance units: false
boundary condition: false
is: CHEBI:12936

metaM 10fthf6glu e
name: 10-formyltetrahydrofolate-[Glu](6)
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
is: HMDB00972
is: CHEBI:57454
has only substance units: false
is: SBO:0000247

metaM CE5786 e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
boundary condition: false
is: CHEBI:27485
name: kinetensin
constant: false
has only substance units: false
is: HMDB02710
type: Species

metaR CRNt
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
modifier: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
name: L-carnitine reversible transport
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
fast: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_26020576_9745_44bf_ba7d_f69d6eab1f70
name: PEMT
constant: false
is encoded by: hsa:10400
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR MECOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
type: Reaction
reactant: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
is: SBO:0000176
name: mesaconate--CoA ligase (GDP-forming)
is described by: ECO:0000304
kinetic law: MODEL1310110013#

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR DCYTDn
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
name: deoxycytidine deaminase, nuclear
modifier: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
fast: false

metaM hcoumarin e
notes: FORMULA: C9H6O3 CHARGE: 0 INCHI: InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
constant: false
is: C09315
is: SBO:0000247
is: CHEBI:27510
name: umbelliferone
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

metaR VLCSp
product: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
name: Very-long-chain-fatty-acid-CoA ligase
fast: false
reversible: false
type: Reaction
is described by: ECO:0000269

metaR RE1517M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
modifier: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
name: RE1517
fast: false
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is: SBO:0000176
type: Reaction

metaR RE2814M
name: RE2814
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
reversible: true

metaM CE2705 c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
has only substance units: false
name: quinonoid dihydrobiopterin
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:52328

metaM C05280 m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
is: SBO:0000247
boundary condition: false
constant: false
name: cis,cis-3,6-Dodecadienoyl-CoA
initial amount: NaN
is: CHEBI:28002
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB03952

metaM pdx5p c
name: Pyridoxine 5'-phosphate
is: CHEBI:58589
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
constant: false
is: C00627
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01319
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_7946eb30_e600_42f3_be03_29e9a1f635b5
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9NS00
initial concentration: NaN
boundary condition: true
is encoded by: hsa:56913
constant: false
type: Species
name: C1GALT1

metaM ile L c
initial concentration: 1.0
is: HMDB00172
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: CHEBI:17191
boundary condition: false
constant: false
name: L-isoleucine

metaM o2s e
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
type: Species
is: HMDB02168
initial amount: NaN
is: SBO:0000247
name: superoxide
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_a3c0ca8b_6a70_4594_aec7_da2854d2734f
name: GPX6
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:257202
has only substance units: false
is: SBO:0000252
is: P59796
type: Species

metaM glcur r
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: D-glucuronate
initial amount: NaN
constant: false
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748

metaM 3ohdcoa m
is: HMDB06402
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: 3-oxopalmitoyl-CoA(4-)
has only substance units: false
boundary condition: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
is: CHEBI:57349

metaR ACOX2x
type: Reaction
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 NJ
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.17.99.3
name: acyl-Coenzyme A oxidase 2, branched chain

http://identifiers.org/biomodels.db/MODEL1310110013#_d2ddc335_158a_4cf2_a7be_cbdfd29df1cd
initial concentration: NaN
name: ALDH3A2
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: P51648
is encoded by: hsa:224
boundary condition: true
has only substance units: false

metaR MACACI
reactant: MODEL1310110013#
name: maleylacetoacetate isomerase
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
kinetic law: MODEL1310110013#
type: Reaction
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110013#
product: MODEL1310110013#

metaR RE3520E
is version of: http://identifiers.org/ec-code/1.11.1.9
name: RE3520
reversible: true
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_be364efc_96ae_4efd_88fe_a0cb4d9ad9e1
is: O00476
boundary condition: true
name: SLC17A3
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10786

metaR ADMDC
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.1.1.50
notes: GENE_ASSOCIATION: (262.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.1.50 Confidence Level: 4 AUTHORS: PMID:2460457 NOTES:
type: Reaction
product: MODEL1310110013#
is: SBO:0000176
name: adenosylmethionine decarboxylase
kinetic law: MODEL1310110013#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110013#
fast: false

metaR CMPACNAtg
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110013#
type: Reaction
name: CMP-Sia Golgi transport via CMP antiport
is: SBO:0000185
reversible: true
product: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_199d5c74_46bf_4930_9e7a_a941fb56f8f7
initial concentration: NaN
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ACLY
is encoded by: hsa:47

metaM oh1 e
notes: FORMULA: HO CHARGE: -1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: hydroxide ion
is: HMDB01039
is: SBO:0000247
is: C01328
boundary condition: false

metaR SPHINGStl
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
name: sphingosine intracellular transport
fast: false
is: SBO:0000185
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_5d91e0b5_f3af_4fea_92d6_a20d9f5e53ab
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: NDUFB9
is encoded by: hsa:4715
constant: false
is: Q9Y6M9
boundary condition: true

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_3506a2a9_c22e_42da_90d0_4439c10615f8
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4695
constant: false
name: NDUFA2
is: SBO:0000252
type: Species
initial amount: NaN
is: O43678

metaM xoltetrol m
constant: false
boundary condition: false
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: HMDB01231
is: CHEBI:17278
has only substance units: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
initial amount: NaN
type: Species
initial concentration: 1.0

metaR ADSS
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
fast: false
modifier: MODEL1310110013#
name: adenylosuccinate synthase
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
reversible: false

metaR DHCR72r
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.1.21
product: MODEL1310110013#
modifier: MODEL1310110013#
name: 7-dehydrocholesterol reductase
type: Reaction
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110013#

metaR FAOXC103C102x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaR HS3ly
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110013#
name: heparan-N-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.10.1.1
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_01e6a77f_83d8_47a9_b712_dd5f0ac298f3
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:23428
name: SLC7A8
type: Species
boundary condition: true
initial concentration: NaN
is: Q86U05

metaR NH4tn
product: MODEL1310110013#
name: ammonia nuclear transport
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

metaM dtmp m
is: CHEBI:26999
initial concentration: 1.0
is: SBO:0000247
is: HMDB01227
is: C00364
boundary condition: false
name: dTMP
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaR MTHFC
reversible: true
fast: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/1.5.1.5
is: SBO:0000176
type: Reaction
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
name: methenyltetrahydrofolate cyclohydrolase

http://identifiers.org/biomodels.db/MODEL1310110013#_9d5df694_3fef_4d5a_b733_e62953746a90
has only substance units: false
type: Species
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR FAOXC2452256x
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110013#
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110013#
type: Reaction
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_99e5598f_521c_4e26_a0ba_d5e7380a4638
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM gumtchol e
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C2760026H5060045NO2530007S CHARGE: 0
is: HMDB00626
type: Species
name: guar gum-taurocholic acid complex
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM man6p c
name: D-Mannose 6-phosphate
constant: false
is: SBO:0000247
is: HMDB01078
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
has only substance units: false
is: CHEBI:17369
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_a5ec45ec_4bbc_4948_a08c_d54e60fda4b8
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2679
boundary condition: true
type: Species
name: GGT3P
initial amount: NaN
is: SBO:0000252
constant: false

metaM Tn antigen g
initial concentration: 1.0
type: Species
boundary condition: false
name: Tn antigen
has only substance units: false
notes: FORMULA: C8H14NO5X CHARGE: 0
initial amount: NaN
is: C04383
is: SBO:0000247
constant: false

metaR DOPASFt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
fast: false
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
name: Dopamine 3-0-sulfate transport (diffusion)
reversible: false
is described by: ECO:0000000

metaR GUACYC
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
name: guanylate cyclase
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
reversible: false
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.6.1.2
is described by: ECO:0000269

metaM 2docopencoa x
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
type: Species
name: 2,7,10,13,16-docosapentenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110013#_402726dc_db07_4126_ad89_f5b769a1b405
initial concentration: NaN
type: Species
is: O75907
constant: false
is encoded by: hsa:8694
has only substance units: false
name: DGAT1
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_a2bfc587_8c7b_4a8c_9102_f5e9a45e62df
has part: Q8TBF5
name: PIGX:PIGM
is: SBO:0000297
has only substance units: false
boundary condition: true
initial concentration: NaN
has part: Q9H3S5
constant: false
is encoded by: hsa:93183
is encoded by: hsa:54965
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_4867b825_47eb_494c_b8a6_726c61ecbd1c
is encoded by: hsa:53947
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9NPC4
name: A4GALT
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_e9a2b9b1_c04f_4ea5_9102_fa3cfaecde36
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: PGM3
is: B4DX94
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5238

metaR MTHFD
is version of: http://identifiers.org/ec-code/1.5.1.5
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
is described by: ECO:0000134
reversible: true

metaR RTOTALt
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL transport
is described by: ECO:0000000

metaM co2 c
notes: FORMULA: CO2 CHARGE: 0
name: CO2
constant: false
is: HMDB01967
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:3313
is: SBO:0000247
is: C00011

metaM cmp c
is: C00055
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00095
type: Species
initial concentration: 1.0
has only substance units: false
name: CMP
is: SBO:0000247

metaR PFK
is version of: http://identifiers.org/ec-code/2.7.1.11
product: MODEL1310110013#
type: Reaction
name: phosphofructokinase
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000304
kinetic law: MODEL1310110013#
reversible: false

metaM docohepcoa m
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/24892790
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
initial concentration: 1.0
type: Species
constant: false
boundary condition: false

metaR PIK5n
name: phosphatidylinositol 5-kinase, nuclear
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#

metaR GALASE19ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
product: MODEL1310110013#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110013#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM hs deg25 l
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: HMDB00127
type: Species
is: CHEBI:15748
notes: FORMULA: C23H37O21 CHARGE: -1
is: SBO:0000247

metaR UGALNACtg
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
product: MODEL1310110013#
name: UDP-GalNAc Golgi transport via CMP antiport
reactant: MODEL1310110013#
type: Reaction

metaM ksi deg14 l
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
is: HMDB00143
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 14

metaR UGCG
name: Ceramide glucosyltransferase
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
type: Reaction
modifier: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.80
kinetic law: MODEL1310110013#

metaR GALASE3ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
modifier: MODEL1310110013#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_2e742cb4_fe3a_4f89_88b4_47b53545888c
name: PFKFB3
is: SBO:0000252
is encoded by: hsa:5209
has only substance units: false
type: Species
is: Q16875
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_4155ce14_2fdf_4aba_80db_37afa4bddcab
is: SBO:0000252
name: ND3
constant: false
is encoded by: hsa:4537
has only substance units: false
initial concentration: NaN
is: P03897
boundary condition: true
type: Species
initial amount: NaN

metaR r0688
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
reactant: MODEL1310110013#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_711479dc_25bc_4cfd_8dca_a12517d36031
has part: Q9NS82
initial amount: NaN
is: SBO:0000297
name: SLC7A10:SLC3A2
initial concentration: NaN
has part: P08195
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6520
is encoded by: hsa:56301
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_638c75e5_cbf8_4ad2_85d2_6cb2c4ff3fc7
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: OXCT2
is: Q9BYC2
boundary condition: true
type: Species
is encoded by: hsa:64064
is: SBO:0000252

metaR URIDK2m
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
fast: false
is described by: ECO:0000134
name: uridylate kinase (dUMP), mitochondrial
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110013#

metaM co2 e
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: SBO:0000247
name: CO2
has only substance units: false
boundary condition: false
is: HMDB01967
constant: false
is: CHEBI:16526
is: C00011

metaM cmp e
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00095
is: SBO:0000247
has only substance units: false
is: CHEBI:60377
boundary condition: false
constant: false

metaM lys L e
is: HMDB00182
name: L-lysinium(1+)
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:32551
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
type: Species

metaM ile L m
initial concentration: 1.0
is: CHEBI:17191
is: HMDB00172
type: Species
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
constant: false
has only substance units: false
name: L-isoleucine
initial amount: NaN
is: SBO:0000247

metaR FTHFL
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110013#
name: Formate-tetrahydrofolate ligase
modifier: MODEL1310110013#
type: Reaction
reversible: true
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_44d1ec1c_256a_42a1_8174_827bf8777716
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: DBT
is encoded by: hsa:1629
is: P11182
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_0b105346_33fa_46ea_bb07_f615a9b9fc13
boundary condition: true
name: IDH3B
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:3420
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_e377e732_324b_4d63_8fc7_f245245925a9
is encoded by: hsa:2184
has only substance units: false
is: SBO:0000252
type: Species
is: P16930
initial concentration: NaN
initial amount: NaN
name: FAH
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_105fe59f_000d_4022_b95d_4bc730a1326d
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM uri c
initial amount: NaN
is: CHEBI:16704
is: HMDB00296
boundary condition: false
name: Uridine
has only substance units: false
type: Species
constant: false
is: C00299
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: SBO:0000247

metaM gal e
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00143
is: C00124
boundary condition: false
constant: false
name: D-Galactose
initial concentration: 1.0
initial amount: NaN
is: CHEBI:0
notes: FORMULA: C6H12O6 CHARGE: 0

metaR r2047
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
type: Reaction
modifier: MODEL1310110013#
is: SBO:0000185

metaR CHOLATEt
modifier: MODEL1310110013#
is described by: ECO:0000269
fast: false
name: cholate transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_5c3a56b8_fa31_4f4e_881c_856aabcd8828
constant: false
boundary condition: true
has only substance units: false
is: Q9UBM1
initial concentration: NaN
type: Species
name: PEMT
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10400

metaR NACHEX24ly
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
type: Reaction
kinetic law: MODEL1310110013#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaM met L c
initial amount: NaN
is: HMDB00696
boundary condition: false
has only substance units: false
type: Species
name: L-methionine
constant: false
is: SBO:0000247
is: CHEBI:16643
initial concentration: 1.0
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075

http://identifiers.org/biomodels.db/MODEL1310110013#_e3c5cf6e_1abc_4109_b50c_b9ea6f0e2d66
is encoded by: hsa:6583
type: Species
is: SBO:0000252
constant: false
name: SLC22A4
has only substance units: false
boundary condition: true
is: Q9H015
initial concentration: NaN
initial amount: NaN

metaR LNLNCACRNt
is: SBO:0000185
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110013#
name: transport into the mitochondria (carnitine)

metaM 3hpp m
initial amount: NaN
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
constant: false
is: HMDB00700
is: CHEBI:16510
is: SBO:0000247
name: 3-hydroxypropionate
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR SCP2x
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: peroxisomal thiolase 2
product: MODEL1310110013#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.176
reversible: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ

http://identifiers.org/biomodels.db/MODEL1310110013#_3c47c31e_ffbf_4891_ba18_8160bae6bfbc
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: HSD17B4
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:3295
type: Species
is: E9PB82

metaM udpgal g
is: HMDB00302
name: UDP-D-galactose(2-)
constant: false
is: CHEBI:58439
has only substance units: false
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR RE3624M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
name: RE3624
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110013#
is described by: ECO:0000000
type: Reaction

metaM lys L c
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
boundary condition: false
has only substance units: false
name: L-lysinium(1+)
type: Species
initial amount: NaN
is: HMDB00182
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaR DCTPtn
is: SBO:0000185
product: MODEL1310110013#
name: dCTP diffusion in nucleus
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM HC02217 e
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27647
has only substance units: false
constant: false
type: Species
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: SBO:0000247
name: prostaglandin-g2

metaR CYTK12n
name: cytidylate kinase (dCMP,dCTP),nuclear
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r0686
is version of: http://identifiers.org/ec-code/2.3.2.2
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
modifier: MODEL1310110013#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reactant: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#

metaR NH4tp
is: SBO:0000185
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
name: ammonia peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110013#_2f6ded24_bd0c_4c80_944d_b593156507e1
is encoded by: hsa:4645
is: Q9H6Y6
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: MYO5B
is: SBO:0000252
constant: false
has only substance units: false

metaM ksi deg35 l
name: keratan sulfate I, degradation product 35
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C68H113N4O54S1 CHARGE: -1
initial concentration: 1.0
is: HMDB00143

metaM core2 g
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:15876
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Core 2
constant: false
notes: FORMULA: C22H37N2O15X CHARGE: 0

metaM udpgal c
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: UDP-D-galactose(2-)
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: CHEBI:58439
type: Species
boundary condition: false
is: HMDB00302
initial concentration: 1.0

metaR GHMT2rm
is: SBO:0000176
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.1
reversible: true
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
name: glycine hydroxymethyltransferase, reversible, mitochondrial
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
fast: false

metaM gal c
is: C00124
constant: false
has only substance units: false
is: HMDB00143
initial concentration: 1.0
is: CHEBI:0
initial amount: NaN
boundary condition: false
type: Species
name: D-Galactose
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0

metaR DHPM1
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000269
name: dihydropyrimidinase (5,6-dihydrouracil)
is version of: http://identifiers.org/ec-code/3.5.2.2
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
fast: false
product: MODEL1310110013#

metaM met L e
is: HMDB00696
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16643
name: L-methionine
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c05d429b_2d60_4d5a_af94_e16665c3449f
is: SBO:0000252
type: Species
boundary condition: true
is: P32929
initial concentration: NaN
name: CTH
is encoded by: hsa:1491
initial amount: NaN
has only substance units: false
constant: false

metaR COUMARINte
type: Reaction
name: xenobiotic transport
fast: false
reactant: MODEL1310110013#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_3cd6e3b6_5d21_4a62_a365_305b5ad5e2c0
type: Species
initial concentration: NaN
initial amount: NaN
name: DGKB
boundary condition: true
has only substance units: false
is encoded by: hsa:1607
constant: false
is: SBO:0000252

metaR r1088
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
product: MODEL1310110013#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
name: Active transport
is described by: ECO:0000000
reactant: MODEL1310110013#

metaR GLYCK2
product: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
name: glycerate kinase

metaM hco3 m
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Bicarbonate
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
is: CHEBI:17544
is: HMDB00595
initial amount: NaN
constant: false
is: SBO:0000247

metaM CE5101 m
is: CHEBI:57795
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
initial amount: NaN
boundary condition: false

metaM ha pre1 e
is: CHEBI:16126
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: hyaluronan biosynthesis, precursor 1
constant: false
has only substance units: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_2d05048e_2f8f_4641_8838_25a3041af7fa
is encoded by: hsa:4846
type: Species
is: A0S0A7
constant: false
name: NOS3
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM udpgal e
initial amount: NaN
has only substance units: false
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
is: CHEBI:58439
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_56311d47_0955_4067_8e41_3c9cb8c36cd5
boundary condition: true
initial amount: NaN
name: ATP5J2
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:9551
is: F8W7V3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_2a5f9e9b_4635_4e12_9215_e9fe9ac93dfb
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5293
name: PIK3CD
boundary condition: true
type: Species
is: A7E2E0
has only substance units: false
initial concentration: NaN

metaM CE2705 n
type: Species
initial concentration: 1.0
is: CHEBI:15374
initial amount: NaN
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
is: SBO:0000247
is: HMDB02281
name: quinonoid dihydrobiopterin
has only substance units: false

metaM hdcoa c
type: Species
name: Hexadecenoyl-CoA (n-C16:1CoA)
is: HMDB06532
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_c99547ea_5589_41b6_a741_d11432547f0d
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: _NOS2A_1_e
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:NOS2A

metaR r1621
modifier: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM xoltetrol c
initial amount: NaN
constant: false
is: CHEBI:17278
has only substance units: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
is: HMDB01231
is: SBO:0000247
type: Species
boundary condition: false

metaM lac L x
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:16651
is: HMDB00190
is: SBO:0000247
boundary condition: false
name: (S)-lactate
initial concentration: 1.0

metaM sph1p e
type: Species
initial concentration: 1.0
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57939
is: HMDB01383

metaR HIStN1
reactant: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
name: Histidine transport (Na, H coupled)
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110013#

metaM o2 m
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
initial concentration: 1.0
initial amount: NaN
name: O2
is: CHEBI:15379

metaR SARDHm
name: Sarcosine dehydrogenase (m)
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
modifier: MODEL1310110013#
fast: false
type: Reaction
product: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.1
is described by: ECO:0000269
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_661a28aa_84ae_4eb1_ba38_7114e859bf49
has only substance units: false
constant: false
type: Species
name: AK4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:205
is: P27144
initial amount: NaN
boundary condition: true

metaR S6TASE18ly
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110013#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR LEUKTRA4t
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reactant: MODEL1310110013#
name: leukotriene A4 transport
product: MODEL1310110013#
is: SBO:0000185
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110013#_7ceed6e5_e4d2_4ff5_947c_8faa3c8e83e0
boundary condition: true
is: Q92535
has only substance units: false
is: SBO:0000252
name: PIGC
initial amount: NaN
is encoded by: hsa:5279
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7b938ca7_5f78_4523_ab77_cc0d2c2c38a8
is encoded by: hsa:100
has only substance units: false
is: P00813
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ADA
constant: false
boundary condition: true
type: Species

metaR r2042
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_c35fd79a_361a_4182_839d_982f336d0108
initial concentration: NaN
has only substance units: false
boundary condition: true
name: CA4
constant: false
type: Species
is: Q6FHI7
initial amount: NaN
is encoded by: hsa:762
is: SBO:0000252

metaR CERT2rt
is described by: ECO:0000000
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
type: Reaction
is: SBO:0000185
fast: false
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1

metaR r1620
type: Reaction
reversible: true
modifier: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110013#

metaM o2 n
is: CHEBI:15379
is: HMDB01377
name: dioxygen
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaR 3AIBtm
product: MODEL1310110013#
is described by: ECO:0000000
name: 3-amino-isobutyrate transport, mitochondrial
reversible: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.6.1.19
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_8e547346_a188_4205_a06d_1c07f3898698
is: SBO:0000252
constant: false
is encoded by: hsa:10873
boundary condition: true
type: Species
initial amount: NaN
name: ME3
is: Q6TCH8
initial concentration: NaN
has only substance units: false

metaR 2DR1PP
reactant: MODEL1310110013#
reversible: false
is described by: ECO:0000000
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD

metaM ribflv c
is: HMDB00244
is: SBO:0000247
name: Riboflavin
initial amount: NaN
is: CHEBI:3554
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
type: Species
is: C00255
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_2ea17498_3ac3_4b73_9307_036a2364780b
is: Q96CA6
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:30
constant: false
boundary condition: true
initial concentration: NaN
name: ACAA1

metaM dttp m
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
has only substance units: false
name: dTTP
initial concentration: 1.0
constant: false
is: C00459
initial amount: NaN
is: CHEBI:37568
is: HMDB01342
is: SBO:0000247

metaM cmp m
boundary condition: false
is: CHEBI:60377
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00095

metaM co2 m
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
name: CO2
is: HMDB01967
is: CHEBI:16526
constant: false
is: SBO:0000247
is: C00011
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011

metaR DNDPt26m
is described by: ECO:0000269
product: MODEL1310110013#
type: Reaction
name: dCDP transport via dUDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110013#
reversible: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_53a5f0d3_75ed_4190_b982_9f88766a489b
type: Species
is encoded by: hsa:23475
name: QPRT
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q15274
initial concentration: NaN
constant: false
boundary condition: true

metaR RE1530M
kinetic law: MODEL1310110013#
name: RE1530
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.21
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
modifier: MODEL1310110013#
fast: false
is: SBO:0000176
product: MODEL1310110013#

metaR r1623
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
fast: false
reversible: true
modifier: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000000

metaR r2044
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110013#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000185

metaR LNELDCCPT1
name: carnitine O-palmitoyltransferase
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaM 2oxoadp m
initial concentration: 1.0
initial amount: NaN
is: HMDB00225
is: CHEBI:57499
boundary condition: false
name: 2-oxoadipate(2-)
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322

metaR DCSPTN1COAtx
kinetic law: MODEL1310110013#
is described by: ECO:0000000
name: fatty acid intracellular transport
fast: false
reactant: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
type: Reaction
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_489dd48e_5ba6_4307_929b_b9b22529bd78
boundary condition: true
type: Species
is encoded by: hsa:2629
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: GBA
constant: false
is: B7Z6S9
is: SBO:0000252

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_6f8c8379_1ed3_4b9b_b33f_ad1a2547006f
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: P23634
boundary condition: true
is encoded by: hsa:493
is: SBO:0000252
initial amount: NaN
name: ATP2B4

http://identifiers.org/biomodels.db/MODEL1310110013#_802f6a36_9ba1_406e_8db7_ac21e2067637
initial concentration: NaN
is encoded by: hsa:2687
initial amount: NaN
is: SBO:0000252
name: GGT5
boundary condition: true
is: P36269
type: Species
has only substance units: false
constant: false

metaR RE0830C
reversible: true
product: MODEL1310110013#
kinetic law: MODEL1310110013#
name: RE0830
reactant: MODEL1310110013#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_0a84728d_bab7_4d77_bcfb_7291e0f0b1db
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5287
boundary condition: true
initial amount: NaN
type: Species
is: O00750
constant: false
name: PIK3C2B

metaM cbasp c
constant: false
is: CHEBI:32814
initial concentration: 1.0
is: C00438
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
name: N-Carbamoyl-L-aspartate
is: HMDB00828
is: SBO:0000247

metaM adp r
name: ADP(3-)
is: HMDB01341
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: CHEBI:456216
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

metaR r1622
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reversible: true
modifier: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_0cf1f927_f140_4b26_8dd2_9e7d1356953d
type: Species
is: P36021
initial amount: NaN
initial concentration: NaN
name: SLC16A2
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:6567

metaR LNELDCCPT2
reversible: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
is described by: ECO:0000000
modifier: MODEL1310110013#
product: MODEL1310110013#

metaR UGT1A10r
is: SBO:0000176
modifier: MODEL1310110013#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is described by: ECO:0000134
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is version of: http://identifiers.org/ec-code/2.4.1.17
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaM hco3 c
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:17544
has only substance units: false
is: C00288
name: Bicarbonate
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
initial amount: NaN
is: HMDB00595
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_c3524619_53e9_44f2_9b91_2a752cd30cbe
type: Species
initial amount: NaN
has only substance units: false
is: Q13454
is: SBO:0000252
name: TUSC3
constant: false
is encoded by: hsa:7991
initial concentration: NaN
boundary condition: true

metaM cmp g
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
is: SBO:0000247
constant: false
is: CHEBI:60377
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: CMP(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_bf2dbc33_d825_43b3_b325_6a96c59c2222
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: CA14
is encoded by: hsa:23632
is: A8K3J4
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_ecbf6f3e_d5d8_485d_b3b9_df97006f5b56
type: Species
initial concentration: NaN
name: PGM2
initial amount: NaN
boundary condition: true
is encoded by: hsa:55276
is: Q96G03
is: SBO:0000252
constant: false
has only substance units: false

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaR CHLtm
is: SBO:0000185
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reactant: MODEL1310110013#
name: choline transport via diffusion (cytosol to mitochondria)
product: MODEL1310110013#

metaM Tn antigen l
is: C04383
constant: false
name: Tn antigen
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C8H14NO5X CHARGE: 0
initial amount: NaN
initial concentration: 1.0

metaM pap g
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
name: adenosine 3',5'-bismonophosphate(4-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58343
has only substance units: false
is: HMDB00061
initial amount: NaN
type: Species

metaM adp m
is: C00008
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01341
is: CHEBI:456216
name: ADP
type: Species
is: http://identifiers.org/pubchem.compound/3310

http://identifiers.org/biomodels.db/MODEL1310110013#_e4c26d12_748e_4738_99f0_74a140647388
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4846
name: NOS3
constant: false
initial amount: NaN
initial concentration: NaN
is: A0S0A7
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_e0a826e1_9a70_4c65_820b_6f9b8c29c9b5
is encoded by: hsa:1337
is encoded by: hsa:9167
is: SBO:0000297
is encoded by: hsa:1347
has part: P14854
type: Species
is encoded by: hsa:1350
is encoded by: hsa:4514
initial amount: NaN
is encoded by: hsa:1329
boundary condition: true
is encoded by: hsa:4512
is encoded by: hsa:1346
is encoded by: hsa:84701
has part: P20674
has part: Q8TF08
has part: H0UI06
has part: P00414
has part: P24310
has part: Q7Z4L0
has part: Q7GXY8
has part: Q96KJ9
is encoded by: hsa:4513
is encoded by: hsa:1327
has part: Q53XN1
is encoded by: hsa:170712
has part: P13073
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: Q53YB7
is encoded by: hsa:1345
has only substance units: false
has part: Q02221
is encoded by: hsa:1351
has part: Q6FGA0
has part: Q6YFQ2
has part: P09669
has part: P12074
has part: P24311
is encoded by: hsa:9377
is encoded by: hsa:341947
is encoded by: hsa:125965
constant: false
is encoded by: hsa:1349
has part: P15954
is encoded by: hsa:1339
has part: Q7GXZ8
initial concentration: NaN
is encoded by: hsa:1340

http://identifiers.org/biomodels.db/MODEL1310110013#_11c1f0af_f2de_4f64_8c2d_121912371f6c
type: Species
initial concentration: NaN
is: Q92521
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9488
initial amount: NaN
constant: false
name: PIGB
boundary condition: true

metaM glcur c
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:15748
boundary condition: false
is: SBO:0000247
constant: false
name: D-glucuronate
is: HMDB00127
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

metaM sphgn c
initial amount: NaN
name: sphinganine(1+)
initial concentration: 1.0
is: HMDB00269
type: Species
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57817

http://identifiers.org/biomodels.db/MODEL1310110013#_06071bda_5ca0_4576_8873_9d17f7f49c6b
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:5091
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: PC

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaR BILDGLCURtr
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
product: MODEL1310110013#
name: glucuronidated compound transport
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_4c6d0801_9e22_4ba8_9574_de0051ec4a81
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:587
name: BCAT2
is: O15382
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_1084cdd1_c9af_4de4_83c5_2fc686234f63
initial concentration: NaN
type: Species
name: CHAT
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1103
is: P28329
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_a83c5096_5079_4da7_afcd_859e082c9346
boundary condition: true
is encoded by: hsa:230
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
is: P09972
name: ALDOC

metaR RE3269C
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
type: Reaction
modifier: MODEL1310110013#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
reactant: MODEL1310110013#
product: MODEL1310110013#
name: RE3269
fast: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.3.48

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM fum m
constant: false
is: CHEBI:29806
name: Fumarate
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
initial concentration: 1.0
is: C00122
is: HMDB00134
boundary condition: false

metaM hco3 e
constant: false
is: CHEBI:17544
is: C00288
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Bicarbonate
initial amount: NaN
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
type: Species

metaR 3SALAOX
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:as described in Bender (Nutritional biochmeistry of the vitamins, 2nd edition) MM
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: cysteinesulfinic acid oxidase

metaM sph1p c
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
is: HMDB01383
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
boundary condition: false

metaM fad x
is: CHEBI:16238
constant: false
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
has only substance units: false
is: SBO:0000247
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
initial concentration: 1.0
boundary condition: false

metaR RE3565C
product: MODEL1310110013#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: RE3565
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_81e906a0_c027_434f_989d_c7bdc3e49b0b
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:33
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ACADL
type: Species
is: P28330
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_11ab3f2b_c856_45a6_998f_92e7722bb574
has only substance units: false
name: ESCO2
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q56NI9
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:157570

metaM ptdcacoa m
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB06499
name: pentadecanoyl Coenzyme A
initial concentration: 1.0
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1
is: SBO:0000247
constant: false

metaR FADtx
fast: false
kinetic law: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reactant: MODEL1310110013#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: FAD transporter, peroxisomal
product: MODEL1310110013#

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM thcholstoic m
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
is: HMDB03873
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
has only substance units: false
boundary condition: false

metaM dttp n
is: HMDB01342
has only substance units: false
constant: false
initial amount: NaN
name: dTTP
boundary condition: false
is: C00459
is: SBO:0000247
is: CHEBI:37568
type: Species
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459

metaM thcrm hs g
has only substance units: false
type: Species
constant: false
is: CHEBI:24636
name: trihexosyl ceramide
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM adp n
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
name: ADP(3-)
initial amount: NaN
type: Species
is: CHEBI:456216
boundary condition: false
is: HMDB01341

http://identifiers.org/biomodels.db/MODEL1310110013#_54c91e9e_65d1_482f_96a1_45f83db6bbb9
is: Q5JT09
is: SBO:0000252
type: Species
is encoded by: hsa:83549
has only substance units: false
boundary condition: true
name: UCK1
initial concentration: NaN
constant: false
initial amount: NaN

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

metaM 20ahchsterol m
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: 20-hydroxycholesterol
has only substance units: false
is: CHEBI:1296
is: HMDB06283
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500

metaM g6p r
is: C00092
is: CHEBI:61548
type: Species
initial amount: NaN
is: HMDB01401
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: D-Glucose 6-phosphate
has only substance units: false
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092

metaM hexdectecoa m
is: HMDB02288
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 2,4,7,10-hexadecatetraenoylcoa
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_006a3e3f_01d3_4626_af92_d2f26503c306
is encoded by: hsa:349565
type: Species
name: NMNAT3
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q96T66

metaM 7dhchsterol c
is: HMDB00032
is: SBO:0000247
initial amount: NaN
is: CHEBI:17759
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
name: cholesta-5,7-dien-3beta-ol
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164

metaM spc hs c
name: sphingosylphosphorylcholine
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5311445
initial amount: NaN
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR r1629
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_e0dc910b_c5b5_41f5_b461_427aa36f7a45
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3417
name: IDH1
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is: O75874

metaM 2oxoadp c
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00225
is: SBO:0000247
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
name: 2-oxoadipate(2-)
has only substance units: false
is: CHEBI:57499
constant: false
boundary condition: false

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM CE5132 c
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
is: CHEBI:57923
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_b6fa7062_f7c0_46b2_8aa5_9c9df25e7f4a
initial amount: NaN
constant: false
has only substance units: false
is: P54868
boundary condition: true
type: Species
name: HMGCS2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3158

metaM 7dhchsterol r
is: CHEBI:17759
is: SBO:0000247
name: cholesta-5,7-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: HMDB00032
initial concentration: 1.0

metaM o2 e
initial concentration: 1.0
initial amount: NaN
is: C00007
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
constant: false
type: Species
has only substance units: false
name: O2
boundary condition: false
is: SBO:0000247
is: HMDB01377

metaM thcholstoic c
constant: false
is: HMDB03873
has only substance units: false
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: SBO:0000247
is: CHEBI:18402
initial concentration: 1.0
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_b721d524_ddc5_4062_8fc5_f9a14adb5cc2
constant: false
is encoded by: hsa:412
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P08842
initial concentration: NaN
has only substance units: false
type: Species
name: STS

metaR FAOXC163C164x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaM ptdcacoa c
constant: false
is: HMDB06499
name: pentadecanoyl Coenzyme A
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C36H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C36H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-27(45)64-20-19-38-26(44)17-18-39-34(48)31(47)36(2,3)22-57-63(54,55)60-62(52,53)56-21-25-30(59-61(49,50)51)29(46)35(58-25)43-24-42-28-32(37)40-23-41-33(28)43/h23-25,29-31,35,46-47H,4-22H2,1-3H3,(H,38,44)(H,39,48)(H,52,53)(H,54,55)(H2,37,40,41)(H2,49,50,51)/p-4/t25-,29-,30-,31+,35-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110013#_a505c52a_bc3e_47ed_b86e_324c9f318537
is encoded by: hsa:6569
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q7Z725
name: SLC34A1
constant: false

metaR r1628
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110013#

metaR r0249
is version of: http://identifiers.org/ec-code/2.7.7.12
product: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
fast: false
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
type: Reaction
reversible: true

metaM fad m
boundary condition: false
name: Flavin adenine dinucleotide oxidized
constant: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01248
is: C00016
type: Species
initial concentration: 1.0
is: CHEBI:16238

metaR 34DHPHELAT1tc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3,4-Dihydroxy-L-phenylalanine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaM HC00900 c
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
name: Methylmalonate
is: CHEBI:30860
initial amount: NaN

metaM co2 r
has only substance units: false
name: CO2
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
is: C00011
is: SBO:0000247
is: CHEBI:16526
is: HMDB01967
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaM adp x
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01341
constant: false
name: ADP(3-)
has only substance units: false
type: Species
is: CHEBI:456216
initial amount: NaN

metaR PMTCOAtx
name: fatty acid intracellular transport
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#

metaR NTD1m
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
modifier: MODEL1310110013#
is: SBO:0000176
name: 5'-nucleotidase (dUMP),mitochondrial
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110013#
reversible: false
product: MODEL1310110013#

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_ff9be54a_d30a_405e_bbc0_ab705c6a1c2e
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6531
initial amount: NaN
is: Q01959
name: SLC6A3
is: SBO:0000252
constant: false

metaM HC01602 c
boundary condition: false
is: C00234
is: SBO:0000247
has only substance units: false
name: 10-Formyltetrahydrofolate
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
initial concentration: 1.0

metaM 56dthm c
is: CHEBI:27468
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
type: Species
name: 5,6-dihydrothymine
is: HMDB00079
is: SBO:0000247
initial concentration: 1.0

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_4eaffa6a_4524_4b94_ae18_ee11f79385bf
is: SBO:0000252
constant: false
name: LEFTY1
is: O75610
boundary condition: true
is encoded by: hsa:10637
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR 4MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
product: MODEL1310110013#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
is: SBO:0000185
is described by: ECO:0000000

metaM o2 c
is: SBO:0000247
is: HMDB01377
initial amount: NaN
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
type: Species
constant: false
has only substance units: false
name: O2
boundary condition: false
initial concentration: 1.0

metaM hcoumarin c
is: C09315
type: Species
initial amount: NaN
constant: false
boundary condition: false
name: umbelliferone
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27510
has only substance units: false
notes: FORMULA: C9H6O3 CHARGE: 0 INCHI: InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H

http://identifiers.org/biomodels.db/MODEL1310110013#_13835f68_e278_4637_93f6_34fa76cb3d31
is: P41222
constant: false
initial concentration: NaN
boundary condition: true
name: PTGDS
is encoded by: hsa:5730
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_62047624_4ac4_4540_839f_691403728a24
is encoded by: hsa:83594
constant: false
is: Q9BQG2
is: SBO:0000252
type: Species
name: NUDT12
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r0472
reversible: true
kinetic law: MODEL1310110013#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
reactant: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_42abb205_7415_4034_af5d_86567b833039
is: Q9HC21
boundary condition: true
constant: false
has only substance units: false
name: SLC25A19
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:60386
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_7cb963b9_f059_4531_ab74_a8cd2a4dbfd9
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: P17516
has only substance units: false
name: AKR1C4
is encoded by: hsa:1109
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_2255d672_0b7e_49a4_861d_798029fb574d
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:34
is: P11310
name: ACADM
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_7b09a271_e626_4ef1_b95e_63b48e2019a0
name: CHAT
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: D3DX95
is: SBO:0000252
is encoded by: hsa:1103
type: Species
constant: false

metaM prostgd2 r
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
name: prostaglandin D2(1-)
is: HMDB01403
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57406

http://identifiers.org/biomodels.db/MODEL1310110013#_ecf9d785_f5a7_41a5_87bf_198e492e11bd
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: P15121
is encoded by: hsa:231
type: Species
name: AKR1B1

http://identifiers.org/biomodels.db/MODEL1310110013#_9fd5789b_dddf_4bb5_82bd_b06e4a0f3207
initial concentration: NaN
is: SBO:0000252
is: Q5JWV8
boundary condition: true
constant: false
name: ACSL4
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:2182

http://identifiers.org/biomodels.db/MODEL1310110013#_5a5711b4_17fc_468a_9d5a_b979cae7b91d
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5152
initial amount: NaN
type: Species
has only substance units: false
constant: false
name: PDE9A
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c2617bd9_a2c0_4018_8c06_cd6be1fe0b02
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI926493
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: _AI926493_1_m

metaR PAIL45P HStn
is described by: ECO:0000000
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110013#
reversible: true
fast: false
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185
product: MODEL1310110013#

metaM lgnccoa x
initial amount: NaN
has only substance units: false
type: Species
name: lignocericyl coenzyme A
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB06526
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_27eaa089_0651_4d2a_b980_0d57f879866f
has only substance units: false
is: SBO:0000252
is: Q9UFY1
is encoded by: hsa:5335
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: PLCG1

metaR GLNtN1
modifier: MODEL1310110013#
type: Reaction
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
name: Glutamine transport (Na, H coupled)
product: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185

metaM glcur e
name: D-glucuronate
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:15748
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_85a48382_a689_4081_b913_c0535621233a
constant: false
has only substance units: false
is encoded by: hsa:5277
is encoded by: hsa:9091
is encoded by: hsa:5279
has part: Q14442
initial concentration: NaN
is: SBO:0000297
boundary condition: true
type: Species
has part: O94777
has part: B3KUV7
is encoded by: hsa:8818
is encoded by: hsa:5283
initial amount: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:51227
has part: Q9BRB3
has part: Q92535

metaM forglu c
boundary condition: false
type: Species
is: CHEBI:18327
initial concentration: 1.0
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: HMDB00854
name: N-Formimidoyl-L-glutamate
is: SBO:0000247
initial amount: NaN
is: C00439
constant: false
has only substance units: false

metaM thp2c c
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB12130
constant: false
is: CHEBI:16987
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
name: 1-piperideine-6-carboxylate

metaR RE1530C
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
reactant: MODEL1310110013#
is described by: ECO:0000000
name: RE1530
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
reversible: true

metaR ADNCYC
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.6.1.1
fast: false
name: adenylate cyclase
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
reactant: MODEL1310110013#
reversible: false
is: SBO:0000176
modifier: MODEL1310110013#
is described by: ECO:0000269
product: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_effd2e62_4056_42da_9b3e_d5eef1fddb4a
name: MTHFD1
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P11586
has only substance units: false
is encoded by: hsa:4522
boundary condition: true
constant: false

metaR r1625
reactant: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR r0474
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
product: MODEL1310110013#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false

metaM r5p r
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
is: SBO:0000247
name: alpha-D-Ribose 5-phosphate
is: HMDB00618
constant: false
is: CHEBI:18189
boundary condition: false
type: Species
initial amount: NaN

metaR r0002
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reactant: MODEL1310110013#
is: SBO:0000185
name: Active transport
is described by: ECO:0000000
product: MODEL1310110013#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110013#

metaM fad r
is: HMDB01248
boundary condition: false
is: CHEBI:16238
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
constant: false

metaR ACGAMPM
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.2.3
modifier: MODEL1310110013#
is described by: ECO:0000269
kinetic law: MODEL1310110013#
reversible: true
type: Reaction
product: MODEL1310110013#
fast: false
name: phosphoacetylglucosamine mutase
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
reactant: MODEL1310110013#

metaR 4ABUTtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: 4-aminobutanoate mitochondrial transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110013#_9fd9e547_22a3_432c_ba7e_dad5355943e4
name: RRM2
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:6241
is: P31350
constant: false
boundary condition: true
initial amount: NaN

metaM cs e deg6 l
boundary condition: false
has only substance units: false
is: CHEBI:57455
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01354
constant: false
notes: FORMULA: C31H48NO32S2 CHARGE: -3
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_706947a1_77b1_40c8_a229_853dfc9560ae
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI934540
initial amount: NaN
has only substance units: false
name: _AI934540_1_c
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_7fd4b83f_d050_473d_be99_4d6405a533c2
type: Species
boundary condition: true
name: SPTLC1
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:10558
is: SBO:0000252
initial amount: NaN
is: O15269

http://identifiers.org/biomodels.db/MODEL1310110013#_0b5a570b_922b_486f_b959_6eaa96473eb3
is: B7Z3W8
initial concentration: NaN
constant: false
name: SLC6A9
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6536

metaR 3SALACBOXL
reversible: false
modifier: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.1.1.29
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.1.15
name: 3-Sulfino-L-alanine carboxy-lyase
is described by: ECO:0000269
is: SBO:0000176
fast: false
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_10115b1a_9774_44a2_8a00_c8c82c9375b6
initial amount: NaN
is encoded by: hsa:5148
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
is encoded by: hsa:5147
has only substance units: false
has part: P18545
is: SBO:0000297
has part: O43924
initial concentration: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_a2bea933_240e_4aa2_8938_ee3246aa15d5
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: PAPSS2
has only substance units: false
initial amount: NaN
is: O95340
is encoded by: hsa:9060
initial concentration: NaN

metaM ksi deg4 l
type: Species
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57737
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 4
is: HMDB00868
initial concentration: 1.0

metaR r1624
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
fast: false

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaM ksi deg7 l
initial concentration: 1.0
is: HMDB01354
type: Species
has only substance units: false
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
boundary condition: false
is: CHEBI:57455
name: keratan sulfate I, degradation product 7
constant: false
initial amount: NaN
is: SBO:0000247

metaM 3ohdcoa x
type: Species
boundary condition: false
name: 3-oxopalmitoyl-CoA(4-)
is: CHEBI:57349
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
has only substance units: false
constant: false
is: HMDB06402

metaR r0475
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaM HC01712 m
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:28391
name: S-Glutaryldihydrolipoamide
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
type: Species
is: SBO:0000247

metaR DGCHOLtx
reactant: MODEL1310110013#
name: bile acid intracellular transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
fast: false

metaM cmp n
name: CMP(2-)
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00095
initial concentration: 1.0
is: CHEBI:60377
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_5d6d3f33_5a13_4928_956c_2233a90edb53
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: UPP1
is encoded by: hsa:7378

metaR CSm
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: citrate synthase
is described by: ECO:0000134
reversible: false
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.1
fast: false
notes: GENE_ASSOCIATION: (1431.1) or (1431.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.7 Confidence Level: 0 AUTHORS: PMID:16006620,PMID:9933076 NOTES:IF old EC number (4.1.3.7) is obsolete -- transferred to 2.3.3.1 NCD. Biochemical
product: MODEL1310110013#
type: Reaction

metaR DHCR242r
reactant: MODEL1310110013#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
kinetic law: MODEL1310110013#
name: 24-dehydrocholesterol reductase [Precursor]
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
is: SBO:0000176
modifier: MODEL1310110013#
product: MODEL1310110013#
fast: false

metaR FAOXC143C123x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaR r1627
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110013#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM hdcoa m
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB06532
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_4a29c86b_6318_497d_a930_1787f9b2e52c
is: SBO:0000252
initial concentration: NaN
name: PRPS2
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5634
is: P11908
has only substance units: false
type: Species

metaR RE0830N
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110013#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
name: RE0830

metaR TYRTA
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110013#
reversible: true
modifier: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
name: tyrosine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_73145b8b_0e8e_4417_b794_e07b523781c1
has part: P07195
has part: P00338
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
name: LDHA:LDHB
is encoded by: hsa:3945
has only substance units: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:3939

http://identifiers.org/biomodels.db/MODEL1310110013#_66b8b3a8_cbac_4690_ae77_2608b2e0ac12
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P23368
name: ME2
is encoded by: hsa:4200
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_d0a5869e_469b_4a97_b6d3_942bca0f74fe
initial concentration: NaN
name: SLC5A8
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:160728
is: Q8N695
boundary condition: true

metaM fum c
is: HMDB00134
type: Species
boundary condition: false
initial concentration: 1.0
name: Fumarate
is: CHEBI:29806
is: SBO:0000247
constant: false
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
has only substance units: false
initial amount: NaN

metaM ksi deg17 l
is: SBO:0000247
boundary condition: false
is: HMDB00143
name: keratan sulfate I, degradation product 17
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
is: CHEBI:12936
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4d971a15_ac39_4879_ac1d_9d30873041f3
initial concentration: NaN
is encoded by: hsa:206
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: _206_1_c

metaR r1626
reactant: MODEL1310110013#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110013#
reversible: true
fast: false
modifier: MODEL1310110013#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#

metaR NCNt
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
modifier: MODEL1310110013#
fast: false
name: Na+/Ca2+-NH4+ exchange
kinetic law: MODEL1310110013#
reversible: true

metaM ribflv e
type: Species
is: HMDB00244
is: SBO:0000247
constant: false
name: Riboflavin
initial amount: NaN
notes: FORMULA: C17H20N4O6 CHARGE: 0
has only substance units: false
is: CHEBI:3554
boundary condition: false
initial concentration: 1.0
is: C00255

metaR PRO Dtde
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
fast: false
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is: SBO:0000185
name: D-proline transport, extracellular
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_ddbdee21_300b_4355_bdf2_156a725b6b2a
type: Species
initial amount: NaN
is: Q5VSR7
is: SBO:0000252
constant: false
is encoded by: hsa:5214
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PFKP

http://identifiers.org/biomodels.db/MODEL1310110013#_9f58b91d_b112_45a2_bede_c5c8e8930407
has part: P57054
boundary condition: true
initial concentration: NaN
has part: B2RAU6
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is: SBO:0000297
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:5277
constant: false
is encoded by: hsa:51227
is encoded by: hsa:5279
is encoded by: hsa:9091

metaM orn e
name: Ornithine
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00214
boundary condition: false
is: CHEBI:0
is: C01602
has only substance units: false

metaM dhor S c
is: HMDB03349
is: CHEBI:30864
boundary condition: false
initial concentration: 1.0
name: (S)-dihydroorotate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_846d852f_f4ff_4cf9_863c_c78409a1090e
constant: false
initial concentration: NaN
is: F8VQS7
is encoded by: hsa:55967
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
name: NDUFA12

http://identifiers.org/biomodels.db/MODEL1310110013#_d7780597_8d08_498d_88f7_1a6d21740172
is encoded by: hsa:3099
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P52789
boundary condition: true
name: HK2
constant: false
type: Species
has only substance units: false

metaR FAOXC143C123m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR SIAASE2ly
name: sialidase, lysosomal
product: MODEL1310110013#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
modifier: MODEL1310110013#

metaR r0009
is: SBO:0000176
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.6.1.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
reversible: false
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false

metaR r1836
reversible: false
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110013#
name: Y+LAT2 Utilized transport
product: MODEL1310110013#
is described by: ECO:0000000
type: Reaction

metaR r0395
type: Reaction
is described by: ECO:0000000
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
kinetic law: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
reactant: MODEL1310110013#
reversible: true
fast: false

metaR MTHGXLt
name: Methylglyoxal transport (cytosol to extracellular)
product: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
fast: false
reactant: MODEL1310110013#
type: Reaction
reversible: false

metaR r0242
fast: false
is: SBO:0000176
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
reversible: true
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_ec353891_aa96_4bb5_ad9f_59684c2de276
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:T83654
has only substance units: false
is: SBO:0000252
name: _T83654_1_e
boundary condition: true
type: Species

metaM sgalside hs c
constant: false
is: SBO:0000247
is: HMDB03406
is: CHEBI:16523
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: sulfatide galactocerebroside
type: Species
has only substance units: false
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1

metaM leu L c
type: Species
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
is: CHEBI:15603
is: SBO:0000247
initial amount: NaN
constant: false
name: L-leucine
has only substance units: false
is: HMDB00687

metaM C05965 e
name: 12(S)-HPETE(1-)
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB04243
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: CHEBI:57444
initial concentration: 1.0

metaM cspg a e
is: SBO:0000247
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
type: Species
initial amount: NaN
is: HMDB00630
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
initial concentration: 1.0
is: CHEBI:16040
has only substance units: false
constant: false

metaR r0456
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.32
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_46f99c44_9d6e_4d50_88a0_3a2d72e3ffd5
is: SBO:0000252
is encoded by: hsa:H53099
constant: false
name: _H53099_1_m
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

metaR RE1254C
reactant: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
type: Reaction
kinetic law: MODEL1310110013#
name: RE1254
product: MODEL1310110013#
is described by: ECO:0000000
reversible: true
fast: false

metaR r0394
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaM tststerone r
type: Species
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: CHEBI:17347
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: testosterone
is: HMDB00234
constant: false

metaR GLUDym
is version of: http://identifiers.org/ec-code/1.4.1.3
modifier: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110013#
is described by: ECO:0000269
type: Reaction
name: glutamate dehydrogenase (NADP), mitochondrial
product: MODEL1310110013#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_5d0c9314_c442_4f27_8177_2570609b4939
is encoded by: hsa:10020
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: GNE
is: B7Z428
is: SBO:0000252

metaR EX coumarin LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: coumarin exchange
type: Reaction

metaM HC02214 c
is: CHEBI:28852
boundary condition: false
has only substance units: false
type: Species
name: prostaglandin-f1alpha
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
constant: false

metaR URATEt
fast: false
name: urate export from cytosol
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
reversible: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#

metaR DADAe
name: Deoxyadenosine deaminase, extracellular
is described by: ECO:0000269
type: Reaction
product: MODEL1310110013#
reversible: false
is: SBO:0000176
reactant: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
kinetic law: MODEL1310110013#

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaR r0393
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
kinetic law: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000000
modifier: MODEL1310110013#
reversible: false
product: MODEL1310110013#
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
fast: false

metaM nadh c
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
is: HMDB01487
boundary condition: false
is: CHEBI:57945
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3306
constant: false
is: C00004

metaR ACCOAC
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM fuc1p L c
initial concentration: 1.0
has only substance units: false
is: CHEBI:28319
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
type: Species
is: HMDB01265
name: L-Fucose 1-phosphate

metaM ump c
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00105
name: UMP
is: CHEBI:57865
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_19d23985_8c31_47fd_8dbc_85b425e47094
initial amount: NaN
is encoded by: hsa:9963
constant: false
is: Q9UHI7
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC23A1
boundary condition: true

metaR NACHEX14ly
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_91eccdae_26a0_482f_97f2_9a50c683e787
is: P00533
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: EGFR
is encoded by: hsa:1956
initial concentration: NaN

metaR r0392
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is: SBO:0000176
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true

metaM xol7ah2al c
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
type: Species
initial amount: NaN
constant: false
is: HMDB06894
has only substance units: false

metaR TDCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000185
name: bile acid intracellular transport
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
type: Reaction

metaM HC01361 e
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
is: CHEBI:17001
name: Dihydroneopterin
initial amount: NaN
boundary condition: false

metaM dcyt n
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: 2'-deoxycytidine
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00014
initial amount: NaN
is: SBO:0000247
is: CHEBI:15698
constant: false

metaR r1832
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
product: MODEL1310110013#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaM 34dhphe c
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:15765
has only substance units: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false
name: L-dopa
initial concentration: 1.0
type: Species
is: HMDB00181

metaR CMPSASn
type: Reaction
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000304
is: SBO:0000176
modifier: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.43
kinetic law: MODEL1310110013#
name: CMP sialic acid synthase, nuclear

http://identifiers.org/biomodels.db/MODEL1310110013#_39bb3163_1d97_42c4_b970_04a6eeed7a19
initial concentration: NaN
is encoded by: hsa:50940
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: PDE11A
is: Q9HCR9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c6ec171f_3334_4587_8340_0d5dc6815687
is encoded by: hsa:29906
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ST8SIA5
is: O15466
type: Species
has only substance units: false

metaM co2 x
boundary condition: false
is: HMDB01967
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
name: carbon dioxide
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
type: Species
is: CHEBI:16526

metaR NADS2
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.5.1
fast: false
name: NAD synthase (glutamine-hydrolysing)
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR RETI1
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110013#
name: retinol isomerase (11-cis)
is: SBO:0000176
product: MODEL1310110013#
is described by: ECO:0000000
fast: false
reversible: true

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_ffe74e57_e256_4cec_b30f_3cd13af73f5c
constant: false
is: Q9H2H9
is encoded by: hsa:81539
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: SLC38A1
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c14c09d1_9667_4de6_a58d_eab966a6c024
is encoded by: hsa:51146
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: A4GNT
is: Q9UNA3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_0d9d2f64_bc6e_40a7_87db_a82af5fce791
is encoded by: hsa:522
has only substance units: false
name: ATP5J
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: Q6NZ59

metaR r0246
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false
type: Reaction

metaM urea m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16199
is: C00086
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
constant: false
is: HMDB00294
boundary condition: false
type: Species
has only substance units: false
name: Urea

metaM galgluside hs c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: galactosyl glucosyl ceramide
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
boundary condition: false
is: HMDB06535

metaR UREAt5
fast: false
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
reactant: MODEL1310110013#
product: MODEL1310110013#
name: urea, water cotransport

metaM o2 x
name: O2
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00007
boundary condition: false
is: CHEBI:15379
is: HMDB01377
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_ed9c0bda_42f9_46cc_aca6_f5174985e63a
initial amount: NaN
is encoded by: hsa:54407
constant: false
is: Q96QD8
name: SLC38A2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR GLCNACASE4ly
type: Reaction
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false

metaM ksi deg36 l
type: Species
initial amount: NaN
name: keratan sulfate I, degradation product 36
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:12936
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
boundary condition: false
has only substance units: false
is: HMDB00143

metaR HS4ly
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
reactant: MODEL1310110013#
fast: false
type: Reaction
modifier: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110013#

metaR r0390
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is: SBO:0000176
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
reversible: true

metaR r1830
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false

metaR r0245
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
product: MODEL1310110013#
reversible: true
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR r1090
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
kinetic law: MODEL1310110013#
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM 34dhphe e
constant: false
is: CHEBI:15765
has only substance units: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false
name: L-dopa
type: Species
initial concentration: 1.0
is: HMDB00181
is: SBO:0000247
initial amount: NaN

metaR FACOAL260
reactant: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
product: MODEL1310110013#
name: fatty-acid--CoA ligase (n-C26:0)

metaR CRNrtx
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
is described by: ECO:0000134
name: reversible transport of L-Carnitine in peroxisome
product: MODEL1310110013#
fast: false
reversible: true
reactant: MODEL1310110013#
type: Reaction

metaM leu L e
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00687
name: L-leucine
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_a5f5105f_d857_47f4_93cc_60eb85df8297
boundary condition: true
type: Species
name: DGKD
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:8527
is: SBO:0000252
is: Q16760

metaR GASNASEly
is described by: ECO:0000000
product: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.26
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
name: glycosylasparaginase, lysosomal
is: SBO:0000176
reversible: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaM dag hs r
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
constant: false
name: diglyceride
initial amount: NaN
is: CHEBI:18035
has only substance units: false
type: Species
boundary condition: false

metaR FUT33g
type: Reaction
reactant: MODEL1310110013#
name: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
fast: false
notes: GENE_ASSOCIATION: (2525.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.65 Confidence Level: 4 AUTHORS: PMID:12424536,PMID:12493760,PMID:1977660 NOTES:NJ
kinetic law: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.65
is described by: ECO:0000269
reversible: false
product: MODEL1310110013#
modifier: MODEL1310110013#

metaR r1770
name: Y+LAT2 Utilized transport
modifier: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM m2mn l
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB06537
initial amount: NaN
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
boundary condition: false
has only substance units: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ebbbbb83_ae36_473a_9c11_259bcca319fe
is encoded by: hsa:1719
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P00374
boundary condition: true
is: SBO:0000252
name: DHFR

metaR S6TASE22ly
product: MODEL1310110013#
reversible: true
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23

metaM amp x
name: AMP
initial amount: NaN
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
is: CHEBI:456215
is: SBO:0000247
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: C00020
is: HMDB00045

http://identifiers.org/biomodels.db/MODEL1310110013#_eb5d0177_1575_40c4_a64c_c8f724136762
has only substance units: false
boundary condition: true
is encoded by: hsa:2678
initial concentration: NaN
name: GGT1
is: SBO:0000252
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_2c1419d7_590b_4fbe_8ca9_d73f2e9cb841
has only substance units: false
constant: false
is encoded by: hsa:51095
initial amount: NaN
is: Q96Q11
is: SBO:0000252
name: TRNT1
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_12694da2_d634_4ef5_ac54_e73179488603
name: TUSC3
constant: false
is encoded by: hsa:7991
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_307f4168_4aed_47c9_84ee_1db40615c15b
initial concentration: NaN
initial amount: NaN
is: B7Z792
constant: false
is encoded by: hsa:4720
is: SBO:0000252
type: Species
has only substance units: false
name: NDUFS2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_57212452_bab1_4897_9bdb_f6778c2aa961
constant: false
is: P24752
name: ACAT1
is encoded by: hsa:38
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

metaR RE0344C
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
modifier: MODEL1310110013#
name: RE0344
reactant: MODEL1310110013#

metaM dhcholestanate x
constant: false
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0

metaR NRVNCt
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_e881efe0_e65b_495f_9e0a_fbb409113aaf
boundary condition: true
is: Q5QPH3
name: ACSS2
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55902
constant: false
is: SBO:0000252
initial amount: NaN

metaR PYRt2m
is described by: ECO:0000000
reactant: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
reversible: true
name: pyruvate mitochondrial transport via proton symport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_1232fc14_0790_4ef2_8ee6_da2c5b52ad7f
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AV717590
name: _AV717590_1_m

metaM idp e
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
boundary condition: false
name: IDP(3-)
initial amount: NaN
is: CHEBI:58280
is: SBO:0000247
is: HMDB03335
type: Species
constant: false
initial concentration: 1.0
has only substance units: false

metaR DNDPt34m
name: dGDP transport via dTDP antiport
type: Reaction
is: SBO:0000185
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000269

metaR FAOXC164C165x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaM orn m
boundary condition: false
initial amount: NaN
is: CHEBI:46912
constant: false
initial concentration: 1.0
name: Ornithine
is: C01602
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
type: Species
is: HMDB00214

http://identifiers.org/biomodels.db/MODEL1310110013#_9f054037_85ec_49eb_9ca2_9aef8d2c88a8
is: O75715
is encoded by: hsa:2880
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: GPX5
initial amount: NaN
type: Species

metaM tettet6 e
type: Species
is: HMDB06246
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
is: SBO:0000247
name: tetracosatetraenoic acid n-6

metaR RE1518M
modifier: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE1518
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_dc032f18_7cd9_4007_9425_132bd5b03d19
has only substance units: false
type: Species
is: Q13630
is: SBO:0000252
initial amount: NaN
name: TSTA3
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7264

http://identifiers.org/biomodels.db/MODEL1310110013#_de866786_d965_4b97_aa0b_c87f294fab76
type: Species
initial amount: NaN
boundary condition: true
name: PANK2
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:80025

metaM HC00718 c
has only substance units: false
constant: false
name: N-methylethanolaminium phosphate(1-)
initial concentration: 1.0
boundary condition: false
is: CHEBI:57781
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
type: Species

metaR AMETr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
reversible: true
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
name: S-Adenosyl-L-methionine intracellular diffusion
fast: false
kinetic law: MODEL1310110013#

metaM 4mptnl m
is: HMDB01318
is: CHEBI:17998
name: 4-methylpentanal
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
is: SBO:0000247

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR r0679
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
is: SBO:0000176
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
reversible: true

metaM sgalside hs l
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: HMDB00904
is: SBO:0000247
initial amount: NaN
name: sulfatide galactocerebroside
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16349

metaM spc hs e
is: http://identifiers.org/pubchem.compound/5311445
is: SBO:0000247
boundary condition: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: sphingosylphosphorylcholine

metaM pmtcoa x
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
boundary condition: false
name: Palmitoyl-CoA (n-C16:0CoA)
type: Species
constant: false
initial amount: NaN
is: C00154
initial concentration: 1.0
is: HMDB01338
is: CHEBI:57379
has only substance units: false
is: SBO:0000247

metaM strdnc e
is: C16300
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/47205608
name: stearidonic acid C18:4, n-3
is: HMDB06547
has only substance units: false
constant: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial amount: NaN

metaR SRTNtu
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000269
name: Serotonin uniport
is: SBO:0000185
kinetic law: MODEL1310110013#
type: Reaction

metaM galgbside hs g
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18259
constant: false
has only substance units: false
name: galactosylgloboside
type: Species
initial amount: NaN

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_04d05865_b00b_4f95_8466_44ef70c88dd7
is: SBO:0000252
is encoded by: hsa:386757
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
name: SLC6A10P

metaR FAOXC163x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_b9ea4c6d_e1f6_450d_95c8_df3038174d08
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:83549
is: Q5JT09
name: UCK1
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR GLYt2r
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
name: glycine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
fast: false
reversible: true

metaM o2s x
initial concentration: 1.0
type: Species
name: superoxide
is: HMDB02168
initial amount: NaN
boundary condition: false
is: CHEBI:18421
is: SBO:0000247
has only substance units: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false

metaR r0119
product: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/5.1.3.14
is described by: ECO:0000000
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:
reversible: false
fast: false
is: SBO:0000176

metaM T antigen g
initial concentration: 1.0
name: T antigen (core 1)
is: CHEBI:22783
has only substance units: false
notes: FORMULA: C14H24NO10X CHARGE: 0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaR CAt7r
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
modifier: MODEL1310110013#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000269
name: calcium / sodium antiporter (1:3), reversible

metaM mescoa m
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:27969
constant: false
is: C06028
initial amount: NaN
name: Mesaconyl-CoA
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_b25daeb4_bcbd_4640_aed9_3175d831a9dc
constant: false
has only substance units: false
initial amount: NaN
is: Q9NPB1
boundary condition: true
name: NT5M
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:56953

metaM dttp c
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
has only substance units: false
name: dTTP
is: CHEBI:37568
is: C00459
is: HMDB01342
initial amount: NaN
is: SBO:0000247
type: Species

metaM dgcholcoa x
name: Chenodeoxyglycocholoyl-CoA
is: HMDB06897
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: C05461
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461

http://identifiers.org/biomodels.db/MODEL1310110013#_80f433af_f0c5_47e9_ba90_4356eb260336
type: Species
is: SBO:0000252
is encoded by: hsa:6390
initial amount: NaN
boundary condition: true
is: P21912
initial concentration: NaN
constant: false
name: SDHB
has only substance units: false

metaR H2Oter
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is: SBO:0000185
reversible: true
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
name: H2O endoplasmic reticulum transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM strdnc c
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: C16300
is: SBO:0000247
is: HMDB06547
name: stearidonic acid C18:4, n-3
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608

http://identifiers.org/biomodels.db/MODEL1310110013#_16e24c00_c5e9_4e15_831e_39f541c1a2d7
constant: false
initial amount: NaN
name: GBA
is: SBO:0000252
is encoded by: hsa:2629
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_0777928f_00d7_443d_99ef_6ca7b20dead3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:57419
constant: false
name: SLC24A3
type: Species
boundary condition: true
is: Q9HC58
initial amount: NaN
initial concentration: NaN

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaM prostgd2 e
boundary condition: false
is: CHEBI:57406
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial concentration: 1.0
name: prostaglandin D2(1-)
has only substance units: false
initial amount: NaN
is: HMDB01403
constant: false
is: SBO:0000247

metaR DCK2n
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.74
name: Deoxycytidine kinase, nuclear (UTP)
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
fast: false
is: SBO:0000176
product: MODEL1310110013#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110013#_d884271b_5dd4_423e_bf13_8d7121cc63aa
has only substance units: false
initial concentration: NaN
name: GUCY1A2:GUCY1B3
has part: P33402
is encoded by: hsa:2983
type: Species
is: SBO:0000297
is encoded by: hsa:2977
boundary condition: true
has part: Q02153
constant: false
initial amount: NaN

metaR PE HStm
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
name: phosphatidylethanolamine scramblase
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false

metaM ump e
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
name: UMP(2-)

metaR CDIPTr
reversible: true
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
reactant: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
is described by: ECO:0000000
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
name: phosphatidylinositol synthase (Homo sapiens)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.8.11

metaM sgalside hs g
is: SBO:0000247
initial concentration: 1.0
name: sulfatide galactocerebroside
type: Species
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:58343
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: HMDB00061

metaR r0672
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110013#

metaR CYTK11n
is: SBO:0000176
name: cytidylate kinase (dCMP,dGTP),nuclear
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110013#
product: MODEL1310110013#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM dttp e
name: dTTP(4-)
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01342
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568

http://identifiers.org/biomodels.db/MODEL1310110013#_181ab613_97eb_4bd6_8a6c_bab172f16188
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1376
name: CPT2
is: P23786
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

metaM amp r
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
is: HMDB00045
name: AMP
boundary condition: false
initial concentration: 1.0
is: CHEBI:456215
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: C00020

metaM HC02179 e
has only substance units: false
initial concentration: 1.0
is: CHEBI:34306
is: SBO:0000247
type: Species
constant: false
name: 20-hydroxy-arachidonate
boundary condition: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial amount: NaN

metaR r0399
type: Reaction
is described by: ECO:0000000
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110013#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaM tststerone e
constant: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
name: testosterone
is: HMDB00234
type: Species
is: CHEBI:17347
has only substance units: false
boundary condition: false
initial amount: NaN

metaR RE1448N
name: RE1448
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:

metaR HSAT3ly
kinetic law: MODEL1310110013#
reversible: false
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110013#

metaM guln r
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB03290
boundary condition: false
initial concentration: 1.0
name: L-gulonate
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: CHEBI:13115

http://identifiers.org/biomodels.db/MODEL1310110013#_3ee620a0_e862_46c5_9784_7df0f0d905c3
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AA629629
has only substance units: false
initial amount: NaN
type: Species
name: _AA629629_1_m
is: SBO:0000252

metaR F1PGT
is: SBO:0000176
name: fucose-1-phosphate guanylyltransferase
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.7.30

metaR ENGASE3ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
name: endo-beta-N-acetylglucosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000
reversible: false

metaM hexdectecoa x
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
name: 2,4,7,10-hexadecatetraenoylcoa
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB02288

metaM prostgd2 c
boundary condition: false
is: CHEBI:57406
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
type: Species
name: prostaglandin D2(1-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01403
constant: false

metaM o2 r
initial amount: NaN
is: CHEBI:15379
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: O2

metaM HC02179 c
name: 20-hydroxy-arachidonate
type: Species
is: SBO:0000247
is: CHEBI:34306
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaM mi4p D c
boundary condition: false
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:58469
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
is: SBO:0000247
is: HMDB01313
name: 1D-myo-inositol 4-phosphate(2-)

metaM ump g
initial amount: NaN
has only substance units: false
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP(2-)
type: Species
is: HMDB00288
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4e403eb7_8907_41f3_9b39_156a4ca77409
initial concentration: NaN
is: SBO:0000252
name: SLC8A3
type: Species
is: P57103
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:6547

metaM tettet6 c
constant: false
is: SBO:0000247
name: tetracosatetraenoic acid n-6
initial amount: NaN
is: HMDB06246
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR ADRNCOAtx
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
product: MODEL1310110013#
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
name: fatty acid intracellular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_0aeaeb5c_14ec_4542_b450_40b90f651839
is: P54886
is encoded by: hsa:5832
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ALDH18A1
type: Species
is: SBO:0000252
constant: false
boundary condition: true

metaM leu L m
initial concentration: 1.0
constant: false
name: L-leucine
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00687
is: CHEBI:15603
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123

metaR r0680
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.137
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_2e02ab91_352a_4e7f_82d4_cf0177d3879e
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3101
type: Species
is: P52790
initial amount: NaN
name: HK3

metaM 5dhf e
boundary condition: false
name: pentaglutamyl folate (DHF)
is: HMDB06487
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1

metaM abt c
is: CHEBI:18403
constant: false
name: L-arabinitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01851

http://identifiers.org/biomodels.db/MODEL1310110013#_285c06d2_b80e_4add_9094_5e6bd9671424
is: Q546Y9
initial amount: NaN
constant: false
is encoded by: hsa:57379
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: AICDA

metaR PPAt
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
name: Propionate transport, diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_6a9b9b58_4046_4fdb_927f_f79d5003e439
has only substance units: false
initial concentration: NaN
name: MBOAT7
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:79143
type: Species
is: Q96N66

metaM 4mptnl e
is: HMDB01318
boundary condition: false
is: CHEBI:17998
name: 4-methylpentanal
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_1841f0ba_8e4f_4b5b_9f9c_470402387107
has part: Q8IV97
is: SBO:0000297
is encoded by: hsa:8140
initial concentration: NaN
name: SLC3A2:SLC7A5
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_85bf7e7d_7c36_46f5_b9b9_23283a971062
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: AGPAT4
constant: false
type: Species
initial concentration: NaN
is: Q9NRZ5
is encoded by: hsa:56895

metaR r1611
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
type: Reaction
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000

metaR GLXO1
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3939.1) or (55293.1) or (3945.1 and 3939.1) or (197257.1) or (92483.1) or (3945.1) or (160287.1) or (3948.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.3.5 Confidence Level: 4 AUTHORS: PMID:12768081,PMID:9038835,PMID:9604807,PMID:9783918 NOTES:NCD
name: glyoxylate oxidase
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.1.2.4
is described by: ECO:0000269
fast: false

metaR NPTHLte
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: xenobiotic transport
reactant: MODEL1310110013#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
product: MODEL1310110013#
type: Reaction

metaM trp L e
is: SBO:0000247
is: CHEBI:16828
name: L-tryptophan
initial concentration: 1.0
boundary condition: false
is: HMDB00929
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080

http://identifiers.org/biomodels.db/MODEL1310110013#_74d37bd1_4e0d_4b38_abbf_c1e46dbeceac
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:223
is: P49189
type: Species
is: SBO:0000252
initial amount: NaN
name: ALDH9A1
has only substance units: false

metaR RNDR1
is described by: ECO:0000254
fast: false
reversible: false
kinetic law: MODEL1310110013#
name: ribonucleoside-diphosphate reductase (ADP)
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_16a28acc_ced7_45d4_ab0a_40f9c8a081a8
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:53354
has only substance units: false
name: PANK1
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaR EX sprm LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_sprm(e)
type: Reaction

metaR r1610
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
is described by: ECO:0000000

metaR ASNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
reversible: false
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110013#
name: L-asparagine transport, mitochondrial

metaR CITt4 4
type: Reaction
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
name: citrate transport via sodium symport
is described by: ECO:0000006
modifier: MODEL1310110013#
is: SBO:0000185
reversible: true
reactant: MODEL1310110013#
fast: false

metaR GLCURtly
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
reversible: true
is described by: ECO:0000269
name: glucuronate transport into lysososme
is: SBO:0000185
modifier: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD

metaM pmtcoa m
has only substance units: false
is: SBO:0000247
is: CHEBI:57379
boundary condition: false
is: HMDB01338
initial concentration: 1.0
type: Species
initial amount: NaN
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154

metaR MCCCrm
name: methylcrotonoyl-CoA carboxylase, mitochondrial
is version of: http://identifiers.org/ec-code/6.4.1.4
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
reactant: MODEL1310110013#
reversible: true
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#

metaM tststerone c
type: Species
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
is: HMDB00234
is: SBO:0000247
is: CHEBI:17347
name: testosterone
constant: false
initial concentration: 1.0
boundary condition: false

metaR THD1m
is version of: http://identifiers.org/ec-code/1.6.1.2
name: NAD(P) transhydrogenase
type: Reaction
modifier: MODEL1310110013#
is described by: ECO:0000269
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
reactant: MODEL1310110013#
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_e193c8b4_02b4_4500_9a01_4ed21b4a9916
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
has part: P08237
name: PFKM:PFKP
is: SBO:0000297
is encoded by: hsa:5213

metaM uri e
boundary condition: false
is: C00299
name: Uridine
is: CHEBI:16704
is: HMDB00296
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_12ef98e9_a1c1_43f3_985d_e214a5b9c953
initial concentration: NaN
constant: false
is: Q8IXW6
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:1809
name: DPYSL3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_7c7635ba_a460_4dda_ae66_b13d16bfb7eb
initial concentration: NaN
is encoded by: hsa:9245
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
name: GCNT3
is: O95395
is: SBO:0000252

metaR LYSOXp
reactant: MODEL1310110013#
fast: false
type: Reaction
product: MODEL1310110013#
name: L-lysine oxidase, peroxisomal
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
is: SBO:0000176
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_d965a43e_e9c5_4186_bbee_1d66c7b8bf2c
is: SBO:0000252
initial concentration: NaN
type: Species
is: O00217
boundary condition: true
name: NDUFS8
has only substance units: false
is encoded by: hsa:4728
constant: false
initial amount: NaN

metaM hpdcacoa m
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
boundary condition: false
name: heptadecanoyl coa
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB06497

metaM tetpent3coa c
is: C16167
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
name: tetracosapentaenoyl coenzyme A, n-3
has only substance units: false
boundary condition: false

metaM 4mptnl c
boundary condition: false
is: HMDB01318
name: 4-methylpentanal
initial concentration: 1.0
is: CHEBI:17998
has only substance units: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
constant: false
type: Species
initial amount: NaN
is: SBO:0000247

metaM trp L c
has only substance units: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial concentration: 1.0
constant: false
type: Species
is: HMDB00929
name: L-tryptophan
is: CHEBI:16828
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR DM atp c
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
name: DM_atp(c)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_59435020_77c0_40a3_acaa_62f691cf3ff9
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: Q8IV97
name: SLC7A5
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8140

metaM 1p3h5c c
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: HMDB01369
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
type: Species
is: CHEBI:6151

metaM npthl e
boundary condition: false
constant: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C10H8 CHARGE: 0 INCHI: InChI=1S/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H EHMN_ABBREVIATION: C00829
is: CHEBI:16482
initial amount: NaN
initial concentration: 1.0
name: naphthalene
is: C00829

metaM aflatoxin e
boundary condition: false
is: CHEBI:2504
constant: false
has only substance units: false
name: aflatoxin B1
initial concentration: 1.0
is: SBO:0000247
is: HMDB06552
initial amount: NaN
type: Species
notes: FORMULA: C17H12O6 CHARGE: 0 INCHI: InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110013#_bdd264a7_adc0_479f_8231_050c657f355a
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN
name: NDUFB4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4710
is: O95168

metaM nadh r
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
type: Species
is: SBO:0000247
is: CHEBI:57945
initial concentration: 1.0
boundary condition: false
name: NADH(2-)
constant: false
is: HMDB01487
has only substance units: false
initial amount: NaN

metaR CITt4 2
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
reversible: true
product: MODEL1310110013#
type: Reaction
fast: false
modifier: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: citrate transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110013#_fba44e16_6aaa_4ce9_9e0b_a34b66dd0132
name: SULT1A1
is encoded by: hsa:6817
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaR r0683
modifier: MODEL1310110013#
reversible: false
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176

metaM amp m
is: HMDB00045
name: AMP(2-)
initial amount: NaN
is: CHEBI:456215
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false

metaR OCOAT1m
is: SBO:0000176
name: 3-oxoacid CoA-transferase
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.8.3.5
product: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
type: Reaction
fast: false
kinetic law: MODEL1310110013#
reversible: true

metaM ump r
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
initial amount: NaN
is: HMDB00288
is: CHEBI:57865
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_1dfd82f4_ff07_4d7d_9d5d_8302cae85d41
boundary condition: true
is encoded by: hsa:8883
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: A8MU28
has only substance units: false
name: NAE1

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_642e91f1_d83e_4d1f_8c02_c4c9eb8dbe7a
constant: false
has only substance units: false
initial concentration: NaN
type: Species
name: NDUFS4
initial amount: NaN
boundary condition: true
is encoded by: hsa:4724
is: SBO:0000252
is: O43181

http://identifiers.org/biomodels.db/MODEL1310110013#_c1802fd7_eea1_4274_943a_bde74add9237
is encoded by: hsa:79611
is: SBO:0000252
type: Species
name: ACSS3
initial concentration: NaN
boundary condition: true
is: Q9H6R3
initial amount: NaN
has only substance units: false
constant: false

metaM xolest2 hs e
type: Species
is: CHEBI:17002
initial amount: NaN
name: cholesterol ester
initial concentration: 1.0
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

metaM retinol cis 11 e
constant: false
is: HMDB06216
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16302
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
name: 11-cis-retinol
is: SBO:0000247

metaM pmtcoa r
is: CHEBI:3454
initial amount: NaN
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
boundary condition: false
is: HMDB01338
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
type: Species
is: C00154
constant: false

metaR TMDK1m
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.21
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV
reversible: false
fast: false
name: thymidine kinase (ATP:thymidine)

metaM ppcoa x
is: HMDB01275
is: CHEBI:57392
has only substance units: false
type: Species
is: C00100
constant: false
initial concentration: 1.0
initial amount: NaN
name: Propanoyl-CoA
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
boundary condition: false

metaM nadh m
initial amount: NaN
initial concentration: 1.0
constant: false
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
is: CHEBI:57945
is: HMDB01487
is: SBO:0000247
boundary condition: false
type: Species
is: C00004
is: http://identifiers.org/pubchem.compound/3306

metaR FAOXC164C165m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_3b282b7a_a7cd_4c9e_9f8a_e377cbfb3a66
initial concentration: NaN
name: PYCR1
is: A6NFM2
constant: false
type: Species
is encoded by: hsa:5831
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_86c4ff39_b029_4a7e_9aca_94feac132054
boundary condition: true
is: P49327
type: Species
name: FASN
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2194

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_3e7d7e07_eb09_4ea5_802c_4c472af7a177
constant: false
boundary condition: true
type: Species
is encoded by: hsa:51
initial concentration: NaN
name: ACOX1
is: B4DK61
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR r1252
fast: false
is: SBO:0000176
reactant: MODEL1310110013#
product: MODEL1310110013#
name: EC:6.2.1.3
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_c9965556_07bc_41de_9a63_9b8a3e1766dd
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is: P50747
name: HLCS
is encoded by: hsa:3141

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaM aflatoxin c
initial concentration: 1.0
type: Species
has only substance units: false
name: aflatoxin B1
is: SBO:0000247
is: CHEBI:2504
constant: false
notes: FORMULA: C17H12O6 CHARGE: 0 INCHI: InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1
is: HMDB06552
boundary condition: false
initial amount: NaN

metaM ksi deg20 l
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 20
is: SBO:0000247
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
type: Species
is: HMDB00143
is: CHEBI:12936
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ef31a902_6950_4c02_a4a2_66f7f67a991f
is encoded by: hsa:AA664770
has only substance units: false
is: SBO:0000252
name: _AA664770_1_m
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
constant: false

metaR GALASE1ly
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110013#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r0801
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM abt e
is: HMDB01851
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:18403
initial concentration: 1.0
name: L-arabinitol

metaR PCm
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
reactant: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.4.1.1
name: pyruvate carboxylase
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110013#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110013#

metaR r0892
is: SBO:0000185
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.2.27
reversible: true
name: Facilitated diffusion
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110013#

metaM xolest2 hs c
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: CHEBI:17002
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: cholesterol ester

metaR r1255
is: SBO:0000176
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110013#
name: EC:6.2.1.3
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_07aff766_ea06_4bcd_af5e_9c72fe6c5c31
is encoded by: hsa:5207
is: P16118
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
name: PFKFB1
initial amount: NaN
is: SBO:0000252

metaM retinol cis 11 c
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB06216
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16302
name: 11-cis-retinol
has only substance units: false

metaR ECOAH9m
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
product: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
fast: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaM ksi deg5 l
type: Species
has only substance units: false
name: keratan sulfate I, degradation product 5
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936
constant: false
is: SBO:0000247
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
boundary condition: false

metaM CE2250 e
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
initial concentration: 1.0
name: 3-oxodocosanoyl-CoA
is: CHEBI:52328

metaR r2050
product: MODEL1310110013#
reversible: false
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000185

metaR SUCCTD
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR FAOXC103C102m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR HMGCOASim
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
name: Hydroxymethylglutaryl CoA synthase (ir)
type: Reaction
is: SBO:0000176
product: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110013#_4b55b340_3075_44d8_b6b8_cbe60a970826
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
is encoded by: hsa:516
has part: Q6FIH7
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaM idp c
is: HMDB03335
is: SBO:0000247
name: IDP(3-)
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
is: CHEBI:58280

http://identifiers.org/biomodels.db/MODEL1310110013#_b9b8b79b_773a_4525_ab42_b047fdbe890c
is: Q9HBF5
constant: false
has only substance units: false
is encoded by: hsa:400410
name: ST20
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_e100e2f9_4010_420a_a03d_e6f6e938bb7f
boundary condition: true
has only substance units: false
is: P21399
initial concentration: NaN
name: ACO1
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:48

metaR DM T antigen g
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR S6TASE21ly
kinetic law: MODEL1310110013#
type: Reaction
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110013#
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_c3963c9f_f357_4d53_88af_313e1f413ded
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:3906
is: SBO:0000252
is: P00709
boundary condition: true
name: LALBA
initial concentration: NaN
type: Species

metaR COAtg
name: CoA transport in Golgi via diffusion
reversible: true
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_8fc56378_ab55_4904_8e51_31bbffdbea08
is encoded by: hsa:159963
constant: false
is: Q1EHB4
name: SLC5A12
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR O2t
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
type: Reaction
reactant: MODEL1310110013#
fast: false
reversible: true
kinetic law: MODEL1310110013#
name: o2 transport (diffusion)

metaM ump n
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
initial concentration: 1.0
is: HMDB00288
initial amount: NaN
type: Species
boundary condition: false
name: UMP(2-)
has only substance units: false

metaR SPRMS
reversible: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.5.1.22
name: spermine synthase
fast: false
modifier: MODEL1310110013#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6611.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.22 Confidence Level: 4 AUTHORS: PMID:7546290 NOTES:NCD
is described by: ECO:0000269

metaR r1619
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: true
modifier: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#

metaM amp e
is: HMDB00045
has only substance units: false
initial amount: NaN
is: CHEBI:456215
type: Species
constant: false
is: C00020
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM 5forthf c
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57456
initial concentration: 1.0
name: 5-Formiminotetrahydrofolate
boundary condition: false
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: C00664
initial amount: NaN
type: Species
is: HMDB01534

metaM CE4790 m
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial amount: NaN
is: CHEBI:57923
is: SBO:0000247
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
has only substance units: false

metaR LTD4DP
kinetic law: MODEL1310110013#
is described by: ECO:0000000
name: Leukotriene D4 dipeptidase
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
type: Reaction
is: SBO:0000176
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#

metaR KCCt
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
kinetic law: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
name: K+-Cl- cotransport
reversible: true
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_ac2e999d_25f6_4ecf_98c6_b84bdb0b6090
is: SBO:0000252
type: Species
has only substance units: false
is: Q8TDY1
is encoded by: hsa:8706
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: B3GALNT1

metaR r1257
fast: false
is: SBO:0000176
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
reversible: false
product: MODEL1310110013#
is described by: ECO:0000000
name: EC:6.2.1.3

metaR r1764
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR NACHEX3ly
product: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110013#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
is described by: ECO:0000000
reactant: MODEL1310110013#

metaM CE5162 r
has only substance units: false
type: Species
name: trans,cis-2,9-octadecadienoyl-CoA
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
is: CHEBI:57923
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

metaR r1618
type: Reaction
modifier: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

metaM od2coa c
is: C16218
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB06529
name: trans-Octadec-2-enoyl-CoA
is: CHEBI:50570
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
initial concentration: 1.0
boundary condition: false

metaR RE2349C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.6.1.64
name: RE2349
reactant: MODEL1310110013#
modifier: MODEL1310110013#

metaM nadh x
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
initial concentration: 1.0
constant: false
is: CHEBI:57945
is: C00004
boundary condition: false
is: SBO:0000247
is: HMDB01487
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7c25e690_132e_46d8_8b6c_dc6df18cc636
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55293
type: Species
name: UEVLD
initial concentration: NaN
has only substance units: false
is: Q8IX04
constant: false
initial amount: NaN

metaM amp c
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2
type: Species
name: AMP
is: C00020
initial amount: NaN
constant: false
is: CHEBI:3322
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r1617
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR r0236
is: SBO:0000176
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
modifier: MODEL1310110013#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.6

http://identifiers.org/biomodels.db/MODEL1310110013#_d37ea1e0_1edf_4d0b_a61f_ba5e0e3ab6a7
boundary condition: true
name: TPI1P2
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:286016
has only substance units: false

metaR BHBt
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_288aae0f_3418_4650_8ce6_ecfe0a1af285
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: _NM_001929_1_c
is encoded by: hsa:NM 001929

http://identifiers.org/biomodels.db/MODEL1310110013#_5428e2c9_bbf1_4a11_b1af_c61e0c9115a1
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: NT5E
initial concentration: NaN
is encoded by: hsa:4907
is: P21589
boundary condition: true

metaR 4NPHte
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reversible: true
name: xenobiotic transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
reactant: MODEL1310110013#
type: Reaction

metaR r1616
modifier: MODEL1310110013#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_e0332810_129e_463f_81c8_a68cb057d54b
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8706
name: B3GALNT1
is: SBO:0000252
has only substance units: false
is: B3KTQ4

metaM pmtcrn c
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:17490
constant: false
initial concentration: 1.0
is: HMDB00222
has only substance units: false
name: L-palmitoylcarnitine

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_41e24c72_7028_46bd_a2b1_6598dc87ef43
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:284098
initial concentration: NaN
name: PIGW
initial amount: NaN
type: Species
boundary condition: true
is: Q7Z7B1

metaM o2s n
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
is: CHEBI:18421
name: superoxide
type: Species
boundary condition: false
is: HMDB02168

metaR r1615
reversible: true
kinetic law: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110013#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR PRPPS
is version of: http://identifiers.org/ec-code/2.7.6.1
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
product: MODEL1310110013#
modifier: MODEL1310110013#
name: phosphoribosylpyrophosphate synthetase
reversible: true
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_861cfc38_d077_4b0c_a951_2d23b71d248a
has only substance units: false
constant: false
is: P49327
is: SBO:0000252
initial concentration: NaN
name: FASN
type: Species
is encoded by: hsa:2194
boundary condition: true
initial amount: NaN

metaR LEUt5m
type: Reaction
name: leucine mitochondrial transport
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110013#
is: SBO:0000185

metaM hexdpencoa x
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
name: 2,4,7,10,13-hexadecapentaenoylcoa
is: HMDB02288
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_942f3fa4_b939_4d2c_a91b_f30335fe89e4
initial amount: NaN
constant: false
is encoded by: hsa:AA278423
name: _AA278423_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_3e7a08fe_3ce6_4262_b089_805f7ddd93f5
initial amount: NaN
is: Q16795
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4704
is: SBO:0000252
boundary condition: true
name: NDUFA9

http://identifiers.org/biomodels.db/MODEL1310110013#_541499dd_b3cc_4967_8329_7c3c5b975e6b
has only substance units: false
type: Species
initial amount: NaN
is: Q8N1Q1
name: CA13
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:377677
is: SBO:0000252

metaM aicar e
is: C04677
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01517
initial concentration: 1.0
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: SBO:0000247
notes: FORMULA: C9H13N4O8P CHARGE: -2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_e2547d74_5af3_404f_894c_cdd487e12ee4
constant: false
initial amount: NaN
is: SBO:0000297
has part: Q8WYR1
boundary condition: true
name: PIK3R5:PIK3CG
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:23533

metaR r0464
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000176

metaM o2s m
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
type: Species
is: C00704
constant: false
boundary condition: false
has only substance units: false
is: HMDB02168
initial amount: NaN
name: Superoxide anion
initial concentration: 1.0
is: SBO:0000247

metaR r1614
type: Reaction
reversible: true
reactant: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM npthl c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00829
constant: false
is: CHEBI:16482
notes: FORMULA: C10H8 CHARGE: 0 INCHI: InChI=1S/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H EHMN_ABBREVIATION: C00829
type: Species
has only substance units: false
name: naphthalene
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_d354f5cd_7f8a_4e00_b8c1_24ca27bb26e3
is: Q10471
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: GALNT2
is encoded by: hsa:2590
is: SBO:0000252

metaR r0809
name: Facilitated diffusion
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
reversible: true
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110013#

metaM 3dhguln c
name: 3-dehydro-L-gulonate
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
is: HMDB06334
has only substance units: false
is: CHEBI:57655
boundary condition: false
type: Species

metaR COAtm
fast: false
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110013#
name: CoA transporter
is described by: ECO:0000269
modifier: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_3717c646_5046_433b_8e89_4d0a669bb0b5
constant: false
is encoded by: hsa:N63787
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
name: _N63787_1_c

http://identifiers.org/biomodels.db/MODEL1310110013#_308c1a82_2e5b_449c_81d7_dbfb76e8110f
initial amount: NaN
type: Species
name: PDE9A
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5152
initial concentration: NaN
boundary condition: true
constant: false

metaR r0899
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
product: MODEL1310110013#
name: Amino acid transporter ATB0+ Facilitated diffusion

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_d887a83a_d629_43b3_ac66_fec571ae35f6
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:80347
boundary condition: true
is: Q13057
is: SBO:0000252
name: COASY

metaM 1p3h5c m
constant: false
type: Species
is: HMDB01369
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial concentration: 1.0
has only substance units: false
is: CHEBI:6151
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM guln c
is: CHEBI:13115
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
constant: false
is: SBO:0000247
name: L-gulonate
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB03290
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_57841887_356f_4524_882e_0e4d0ac22c53
name: PRPS1L1
has only substance units: false
type: Species
is encoded by: hsa:221823
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

metaM ptdca c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/22169126
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
type: Species
is: HMDB00826
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
name: pentadecanoate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_d930d430_cf58_4876_9784_f2e237107a6d
name: _U37519_1_m
constant: false
is: SBO:0000252
is encoded by: hsa:U37519
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

metaR PHETHPTOX2
is: SBO:0000176
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
kinetic law: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.14.16.1
is described by: ECO:0000269
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
type: Reaction
product: MODEL1310110013#
fast: false
modifier: MODEL1310110013#

metaR COAtn
kinetic law: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: coenzyme A transport, nuclear
product: MODEL1310110013#
reversible: true
type: Reaction

metaR r1613
is described by: ECO:0000000
reactant: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110013#_e9919119_6c11_40ad_a219_19b35fbe44e2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2180
is: P33121
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: ACSL1

http://identifiers.org/biomodels.db/MODEL1310110013#_a2cae5bd_72b6_4448_b205_094c0e7a05e8
constant: false
is encoded by: hsa:2531
is: SBO:0000252
initial concentration: NaN
name: KDSR
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: Q06136

metaR RE1573M
is: SBO:0000176
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
name: RE1573
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_910f6414_1e7c_42a1_a9f0_860ebe7d4f67
name: ALPPL2
has only substance units: false
initial amount: NaN
is encoded by: hsa:251
boundary condition: true
constant: false
is: P10696
type: Species
is: SBO:0000252
initial concentration: NaN

metaR 3MOBte
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: Transport of 3-methyl-2-oxobutanoate
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_e97b9a26_e0e6_49ad_95d6_761262a1f0f7
type: Species
name: MAOB
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4129
constant: false
initial concentration: NaN
initial amount: NaN
is: P27338

metaR r1612
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR B3GNT51g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
type: Reaction
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is described by: ECO:0000304
fast: false
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_41448e80_dd2c_406c_a17f_7cdc3fb1d0a0
initial amount: NaN
constant: false
is: Q6IBA0
name: NDUFS5
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:4725
initial concentration: NaN
boundary condition: true

metaM ptdca e
is: http://identifiers.org/pubchem.compound/22169126
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: pentadecanoate
is: HMDB00826
boundary condition: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_1dbfb651_b933_4e63_93cb_6a68d55a266f
name: COX5B
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: Q53YB7
is encoded by: hsa:1329
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR BTNt4i
is: SBO:0000185
product: MODEL1310110013#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110013#
name: Biotin uptake (antiport)
reversible: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction

metaM orn c
has only substance units: false
is: C01602
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
is: HMDB00214
is: CHEBI:0
initial amount: NaN

metaR r0463
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110013#
fast: false
reversible: true
product: MODEL1310110013#
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:

metaM nicrnt c
constant: false
has only substance units: false
name: Nicotinate D-ribonucleotide
is: C01185
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01132
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: CHEBI:57502

metaM ksi deg32 l
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
type: Species
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936
has only substance units: false
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 32
initial amount: NaN
boundary condition: false

metaM eicostet e
is: HMDB02177
has only substance units: false
constant: false
is: SBO:0000247
name: eicosatetranoic acid
initial concentration: 1.0
type: Species
is: CHEBI:36033
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_41f5eb8d_b33c_41d0_a49b_8091037c12a9
initial amount: NaN
is encoded by: hsa:8034
is: P16260
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC25A16
type: Species

metaM CE5125 x
is: SBO:0000247
constant: false
is: CHEBI:12947
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
initial amount: NaN
name: (2S)-pristanoyl-CoA
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaR r2357
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#

metaM 5adtststerones c
is: HMDB06278
has only substance units: false
boundary condition: false
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_fd056609_1a0c_434c_a666_6e8a3f998e93
type: Species
constant: false
name: PAFAH2
initial amount: NaN
is encoded by: hsa:5051
is: SBO:0000252
is: Q99487
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM thym c
has only substance units: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
name: Thymine
is: HMDB00262
is: C00178
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17821
boundary condition: false
is: SBO:0000247
constant: false

metaM 4hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
name: 4,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
boundary condition: false
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110013#_60f2f70d_0993_42de_8979_2d8f1ab48f4d
has only substance units: false
type: Species
constant: false
is encoded by: hsa:728637
initial concentration: NaN
is: SBO:0000252
name: _728637_1_c
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_4e9fa333_fe9e_4fef_93a8_52eac7e5fde5
initial concentration: NaN
name: _R33828_1_c
is encoded by: hsa:R33828
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM pydx5p e
is: HMDB01491
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
name: pyridoxal 5'-phosphate(2-)
type: Species
initial concentration: 1.0
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
is: CHEBI:597326

metaM gly e
constant: false
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
has only substance units: false
name: Glycine
is: SBO:0000247
is: C00037
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:3339
is: HMDB00123

http://identifiers.org/biomodels.db/MODEL1310110013#_91ee801b_5a6c_4a2d_b74a_f1b17b1dd74d
type: Species
initial amount: NaN
name: PIK3R2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is: O00459
is encoded by: hsa:5296

metaR r2358
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_054296ac_f0dc_41f6_a4a5_a48b8cb6158d
name: SLC2A8
is: SBO:0000252
initial concentration: NaN
is: Q9NY64
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:29988
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_f677dfe7_f362_4ba3_8d15_3e707dcbadde
initial concentration: NaN
constant: false
is encoded by: hsa:6535
has only substance units: false
is: SBO:0000252
boundary condition: true
is: B4DIA3
initial amount: NaN
type: Species
name: SLC6A8

http://identifiers.org/biomodels.db/MODEL1310110013#_2649c432_c111_4a13_ac7c_0b10e9f87b74
name: B3GALT5
type: Species
is encoded by: hsa:10317
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaR SERtN1
reactant: MODEL1310110013#
type: Reaction
name: Serine transport (Na, H coupled)
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
is: SBO:0000185
fast: false
modifier: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_cdbd4d7f_a86a_4fda_9553_606785cca0de
is encoded by: hsa:5105
is: P35558
name: PCK1
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaM amet c
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
name: S-Adenosyl-L-methionine
is: HMDB01185
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00019
boundary condition: false
is: CHEBI:15414
has only substance units: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaM pmtcrn x
initial amount: NaN
boundary condition: false
name: L-palmitoylcarnitine
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
is: HMDB00222
is: SBO:0000247

metaM 5adtststerones e
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
initial concentration: 1.0
name: 5alpha-Dihydrotestosterone sulfate
has only substance units: false

metaM cgly e
type: Species
is: HMDB00078
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial concentration: 1.0
name: L-cysteinylglycine
initial amount: NaN
is: CHEBI:4047
boundary condition: false

metaR r0660
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
product: MODEL1310110013#
reactant: MODEL1310110013#

metaR PPItm
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
reactant: MODEL1310110013#
name: diphopshate transporter, mitochondrial
is described by: ECO:0000134
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true
type: Reaction

metaR r2359
reversible: true
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_254d86a7_72af_4ff0_b125_9211a7e10ebf
boundary condition: true
is: SBO:0000252
is encoded by: hsa:43
initial concentration: NaN
name: ACHE
is: P22303
initial amount: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_672c2a1f_a1f8_4b59_89a9_fdeb338e27eb
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AA977580
boundary condition: true
name: _AA977580_1_c

metaR r0340
reversible: false
fast: false
reactant: MODEL1310110013#
is: SBO:0000176
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110013#

metaR TRIODTHYt2
name: T3 transport via facilitated diffusion
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110013#_7ed8be06_0f4f_4705_bfa4_4b22a22532b6
initial amount: NaN
has only substance units: false
is: P53597
is: SBO:0000252
name: SUCLG1
constant: false
is encoded by: hsa:8802
initial concentration: NaN
type: Species
boundary condition: true

metaM gly c
initial concentration: 1.0
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0
name: Glycine
constant: false
is: SBO:0000247
is: C00037
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:3339

metaM pydx5p c
constant: false
is: CHEBI:597326
type: Species
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
name: Pyridoxal 5'-phosphate
is: HMDB01491
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00018

metaR GGH 5DHFe
is: SBO:0000176
product: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
modifier: MODEL1310110013#
fast: false
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (5DHF), extracellular

metaR r0661
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaM dcsptn1coa m
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB06513
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173
boundary condition: false

metaM glyc3p x
is: C00093
is: HMDB00126
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
name: Glycerol 3-phosphate
is: CHEBI:57597
is: SBO:0000247
initial concentration: 1.0

metaR FOLt2le
is described by: ECO:0000134
product: MODEL1310110013#
reversible: true
name: folate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110013#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_03de685b_f7db_4543_8db4_afb522006f38
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:23556
boundary condition: true
is: SBO:0000252
type: Species
name: PIGN

http://identifiers.org/biomodels.db/MODEL1310110013#_e122b3a7_5dd6_40cc_a301_ce74594814d3
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: ATP5G2
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:517

metaM cgly c
has only substance units: false
name: L-cysteinylglycine
type: Species
is: CHEBI:4047
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00078

metaR HEXDIACTD
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_f0684eeb_0e50_454f_9ec1_87581208841c
initial amount: NaN
type: Species
name: SLC2A6
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is: Q9UGQ3
boundary condition: true
is encoded by: hsa:11182

metaR AICARte
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
is described by: ECO:0000134
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_1a247e11_ef1e_447c_9c6b_c7ba6019716b
has only substance units: false
is encoded by: hsa:27115
type: Species
initial amount: NaN
is: Q9NP56
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: PDE7B

http://identifiers.org/biomodels.db/MODEL1310110013#_d0983ee1_c028_4ce6_b22a_88789516ba8d
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:518
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
constant: false

metaM CE1925 e
has only substance units: false
boundary condition: false
is: CHEBI:57923
is: SBO:0000247
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
name: 3'-carboxy-alpha-chromanol

http://identifiers.org/biomodels.db/MODEL1310110013#_5dde5bd6_4851_48f9_95c4_688d8d9395bb
initial amount: NaN
is encoded by: hsa:48
name: ACO1
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P21399
has only substance units: false
boundary condition: true

metaM tag hs e
is: CHEBI:17855
type: Species
has only substance units: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: triglyceride

metaR r0779
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110013#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
reactant: MODEL1310110013#
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4

http://identifiers.org/biomodels.db/MODEL1310110013#_608e1bc0_1f2c_47da_b3ae_bd88ad6ce321
is: SBO:0000252
has only substance units: false
name: PDE6A
initial amount: NaN
is: P16499
is encoded by: hsa:5145
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaR CHATn
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
name: Choline O-acetyltransferase
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#

metaR FAOXC102C81x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaM fuc L l
boundary condition: false
name: L-fucose
constant: false
is: CHEBI:18287
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
has only substance units: false
type: Species
is: HMDB00174

metaR ALCD21 D
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.99.24
reactant: MODEL1310110013#
is: SBO:0000176
fast: false
product: MODEL1310110013#
reversible: false
name: alcohol dehydrogenase (D-1,2-propanediol)
is version of: http://identifiers.org/ec-code/1.1.1.1

http://identifiers.org/biomodels.db/MODEL1310110013#_d5cb1500_f58d_461e_81ac_c926f47dccf9
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:3990
name: LIPC
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: A6H8L5

metaM tag hs c
name: triglyceride
boundary condition: false
has only substance units: false
is: CHEBI:17855
type: Species
is: SBO:0000247
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_044ca397_601a_456c_b46f_4aade13f311d
type: Species
name: _AI435857_1_x
is encoded by: hsa:AI435857
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false

metaM lthstrl r
initial amount: NaN
is: CHEBI:17168
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB01170
name: 5alpha-cholest-7-en-3beta-ol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189

metaM pe hs m
constant: false
initial amount: NaN
is: CHEBI:16038
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
name: phosphatidylethanolamine

metaM hs deg18 l
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
boundary condition: false
is: HMDB06210
initial concentration: 1.0
initial amount: NaN
name: heparan sulfate, degradation product 18
type: Species
constant: false
has only substance units: false
is: SBO:0000247

metaM hspg e
constant: false
initial amount: NaN
is: HMDB02259
name: heparan sulfate proteoglycan
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: CHEBI:32366
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR GLCNACASE3ly
is described by: ECO:0000000
product: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110013#

metaR FACOAL246 1
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
name: fatty-acid--CoA ligase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_d01017ab_88f0_43b1_a121_c8a939ff87a2
boundary condition: true
constant: false
has only substance units: false
name: DGKB
is encoded by: hsa:1607
initial amount: NaN
initial concentration: NaN
is: Q9Y6T7
is: SBO:0000252
type: Species

metaM omhpal r
initial amount: NaN
is: HMDB06294
initial concentration: 1.0
is: SBO:0000247
name: w-hydroxypalmiticacid
constant: false
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_72259753_5fa2_48b6_ad0a_a63598a4cffd
is: Q8NFF2
has only substance units: false
boundary condition: true
is encoded by: hsa:123041
is: SBO:0000252
initial amount: NaN
constant: false
name: SLC24A4
initial concentration: NaN
type: Species

metaR FAOXC101C102x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaR EX pydxn LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Pyridoxine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_d49ecbfd_c0ee_43f3_a450_3a379fe510ae
constant: false
is encoded by: hsa:80025
initial concentration: NaN
name: PANK2
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species

metaR LNLNCGt
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaM crn m
constant: false
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
boundary condition: false
name: L-Carnitine
type: Species
initial concentration: 1.0
is: HMDB00062
is: C00318
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_d8a0a060_2e2b_4761_aeb3_13a8d81d7c7b
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:AD000092
name: _AD000092_1_c
is: SBO:0000252
type: Species
boundary condition: true

metaM eicostet c
constant: false
boundary condition: false
is: CHEBI:36033
type: Species
is: HMDB02177
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: eicosatetranoic acid

http://identifiers.org/biomodels.db/MODEL1310110013#_9dada479_0935_47d9_a126_40bb62a8f048
is: SBO:0000252
name: SLC25A20
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:788
is: O43772
boundary condition: true

metaM HC01408 m
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:27648
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
is: SBO:0000247
constant: false
name: 3-Oxohexanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110013#_9f613140_c9a4_4bb2_bc05_bd33f8c6d23c
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2678
name: GGT1
constant: false
is: SBO:0000252
is: P19440

metaR ILEt5m
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Isoleucine mitochondrial transport
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110013#

metaR S6TASE8ly
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.4.16.5
name: N-acetylgalactosamine-6-sulfatase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR FACOAL184
product: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110013#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110013#
reversible: true
type: Reaction
fast: false

metaR ABO1g
is version of: http://identifiers.org/ec-code/2.4.1.37
is: SBO:0000176
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
fast: false
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
is described by: ECO:0000269

metaM nrvnccoa x
boundary condition: false
is: C16532
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
name: nervonyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
has only substance units: false

metaR RE2649C
type: Reaction
product: MODEL1310110013#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
name: RE2649
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
fast: false

metaM dcholcoa x
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
has only substance units: false
is: CHEBI:28701

http://identifiers.org/biomodels.db/MODEL1310110013#_49bf8849_7767_477f_abad_b759e8af4f24
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:U52111
type: Species
name: _U52111_1_c

metaR r1609
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#

metaM dolmanp L c
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: Dolichyl phosphate D-mannose, human liver homolog
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:15809

http://identifiers.org/biomodels.db/MODEL1310110013#_961b0c26_9a80_431a_9862_0bb93a733670
constant: false
initial concentration: NaN
name: SLC25A5
type: Species
is: Q6NVC0
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:292
is: SBO:0000252

metaM dtdp c
is: HMDB01274
is: CHEBI:58369
initial amount: NaN
is: C00363
is: SBO:0000247
constant: false
type: Species
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR UGLCNACtg
is described by: ECO:0000269
product: MODEL1310110013#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
name: UDP-GlcNAc Golgi transport via CMP antiport
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
type: Reaction

metaR KHte
name: KHte
product: MODEL1310110013#
reversible: true
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
is: SBO:0000185

metaM accoa g
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: acetyl-CoA(4-)
is: CHEBI:57288
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

http://identifiers.org/biomodels.db/MODEL1310110013#_8503cfc0_e063_4ba3_a79d_95c117713c7f
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6560
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: F5H066
name: SLC12A4

metaR FATP2t
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
name: fatty acid electroneutral transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaR KCC2t
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000269
name: K+-Cl- cotransporter (NH4+)
is: SBO:0000185
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
reactant: MODEL1310110013#
fast: false
reversible: true
product: MODEL1310110013#

metaR r1608
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
reversible: true
fast: false

metaM tyr L e
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00158
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895

metaR r2419
reversible: true
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110013#
is: SBO:0000185

metaM dcsptn1coa c
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C16173
boundary condition: false
type: Species

metaM gly m
initial concentration: 1.0
is: C00037
type: Species
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: SBO:0000247
is: CHEBI:15428
name: Glycine
initial amount: NaN
has only substance units: false
is: HMDB00123
boundary condition: false

metaR RE1526M
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
name: RE1526
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110013#_1821959f_d6f3_4733_ba5d_594a79e1595d
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:H17063
initial concentration: NaN
name: _H17063_1_c
has only substance units: false
constant: false
type: Species

metaM HC01842 c
type: Species
initial amount: NaN
initial concentration: 1.0
name: Phosphodimethylethanolamine
has only substance units: false
is: CHEBI:31997
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_3b1adeb8_11cf_4d06_8920_423e0c0604ac
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3073
is: P06865
type: Species
constant: false
name: HEXA
boundary condition: true

metaR r0668
is version of: http://identifiers.org/ec-code/2.4.2.19
reversible: true
fast: false
reactant: MODEL1310110013#
is described by: ECO:0000000
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
is: SBO:0000176

metaR CAATPS
reactant: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.8
name: Ca ATPase
is described by: ECO:0000269
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: false
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ

metaM hspg l
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: CHEBI:17899
boundary condition: false
has only substance units: false
is: HMDB01993
type: Species
initial concentration: 1.0
initial amount: NaN
name: heparan sulfate proteoglycan
constant: false
is: SBO:0000247

metaR RIBt
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
fast: false
name: ribose transport via diffusion
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

metaM dtdp e
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
boundary condition: false
is: SBO:0000247
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_617485af_fcd6_4251_af10_4a60e027120f
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: Q59EH3
is encoded by: hsa:52
name: ACP1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_46cbf4c8_b0d2_4133_aee5_abd515abecb1
initial amount: NaN
has only substance units: false
name: _AI971036_1_c
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AI971036

metaM CE2433 m
boundary condition: false
is: CHEBI:57795
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaR OCCOAtx
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110013#
is described by: ECO:0000000
name: fatty acid intracellular transport
type: Reaction
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_de0904e8_6241_4199_962b_0a2d9fd4286c
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
name: NDUFB1
is: O75438
initial amount: NaN
is encoded by: hsa:4707
initial concentration: NaN
constant: false

metaR HYXNt
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reactant: MODEL1310110013#
name: Hypoxanthine transport
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110013#
fast: false

metaM tyr L c
name: L-tyrosine
is: CHEBI:17895
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: HMDB00158
constant: false

metaR r0669
is: SBO:0000176
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#

metaM pmtcrn r
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
is: CHEBI:17490
is: HMDB00222
has only substance units: false
name: L-palmitoylcarnitine

metaR r0926
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
name: Postulated transport reaction
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_447c97cb_6708_4cf0_a185_f860b8662198
initial concentration: NaN
name: GALE
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: Q14376
is encoded by: hsa:2582
is: SBO:0000252
has only substance units: false

metaR CRVNCtr
reversible: true
product: MODEL1310110013#
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110013#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110013#
type: Reaction

metaR NTD11
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
product: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
name: 5'-nucleotidase (IMP)
is described by: ECO:0000269
reactant: MODEL1310110013#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaM fol m
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:27470
name: Folate
constant: false
is: HMDB00121
type: Species
initial concentration: 1.0

metaM hexe3coa x
type: Species
initial concentration: 1.0
is: HMDB06522
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: 3-hexenoylcoa
has only substance units: false

metaM amet m
type: Species
is: CHEBI:15414
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
is: HMDB01185
name: S-Adenosyl-L-methionine
is: SBO:0000247
is: C00019
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false

metaM pe hs c
boundary condition: false
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: phosphatidylethanolamine
constant: false
has only substance units: false
is: CHEBI:16038

metaR r2352
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_32792707_d77e_49fc_b935_123c5216cd00
is: SBO:0000252
name: NPR1
type: Species
is: P16066
boundary condition: true
constant: false
is encoded by: hsa:4881
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR COAtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: COA transporter, endoplasmic reticulum
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_5c738049_541f_43f8_9185_0888a6f1edc3
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8875
type: Species
initial concentration: NaN
is: O95498
name: VNN2

http://identifiers.org/biomodels.db/MODEL1310110013#_0d720b8d_3e7f_4c24_97cd_2ec8c543d134
name: SLC7A10
is encoded by: hsa:56301
boundary condition: true
is: Q9NS82
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_54095ab2_ac96_4da4_a5ba_331f960147d5
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: GAD1
is encoded by: hsa:2571
type: Species
is: Q99259

metaM aicar c
initial concentration: 1.0
initial amount: NaN
constant: false
is: C04677
is: HMDB01517
type: Species
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: CHEBI:58475
is: SBO:0000247
boundary condition: false
has only substance units: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide

http://identifiers.org/biomodels.db/MODEL1310110013#_5632838d_2da8_42c1_b1f3_69a44185d349
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SOAT1
is encoded by: hsa:6646
is: B4DU95

metaR r2200
reversible: true
product: MODEL1310110013#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_5dc49ad0_489d_4e50_a17e_c0dd6cbf774e
has only substance units: false
type: Species
is encoded by: hsa:6647
initial amount: NaN
constant: false
is: SBO:0000252
is: P00441
initial concentration: NaN
name: SOD1
boundary condition: true

metaR PPItx
reactant: MODEL1310110013#
type: Reaction
fast: false
name: Diphosphate transporter, peroxisome
reversible: true
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185

metaR r2353
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
is described by: ECO:0000000

metaR RE3244R
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110013#
type: Reaction
name: RE3244

metaM accoa c
type: Species
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
is: HMDB01206
initial amount: NaN
name: Acetyl-CoA
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
is: C00024
is: CHEBI:57288

metaR STRDNCt
name: fatty acid transport via diffusion
is: SBO:0000185
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reversible: true

metaM gt3 hs g
is: SBO:0000247
type: Species
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
boundary condition: false
initial concentration: 1.0
name: GT3
is: CHEBI:28424
constant: false
initial amount: NaN
has only substance units: false

metaR FADH2tru
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
fast: false
reversible: false
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: FADH2 transporter, endoplasmic reticulum
reactant: MODEL1310110013#

metaR ORNALArBATtc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Alanine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR NCKt
fast: false
reversible: true
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-K+ exchange
type: Reaction
modifier: MODEL1310110013#
is: SBO:0000185

metaM fuc L c
boundary condition: false
constant: false
is: CHEBI:18287
initial concentration: 1.0
type: Species
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial amount: NaN
name: L-fucose
is: SBO:0000247
has only substance units: false

metaR r2354
reactant: MODEL1310110013#
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
product: MODEL1310110013#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM pe hs e
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
constant: false
name: phosphatidylethanolamine
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16038
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_2264f1bd_bcaa_4389_8cc7_f6eec0b2fd2d
is: P04035
name: HMGCR
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:3156
type: Species
boundary condition: true

metaR r2201
product: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_e23d938c_8a65_48f3_8632_aa94be4c2f98
is encoded by: hsa:2109
is encoded by: hsa:2108
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN
has part: P13804
is: SBO:0000297
name: ETFA:ETFB
has only substance units: false

metaM dcholcoa r
is: HMDB06292
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
type: Species
boundary condition: false
is: CHEBI:28701
has only substance units: false
constant: false
initial amount: NaN

metaM crn e
has only substance units: false
boundary condition: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
is: SBO:0000247
name: L-Carnitine
type: Species
is: HMDB00062
is: CHEBI:16347
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_13fdf93a_7539_4f2c_a3af_f74482fb1289
constant: false
is encoded by: hsa:10400
name: PEMT
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

metaR COAtp
fast: false
type: Reaction
name: coenzyme A transport, peroxisomal
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_4d359112_faad_4f00_a211_e292030ddf2b
is encoded by: hsa:4728
has only substance units: false
boundary condition: true
is: O00217
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: NDUFS8

http://identifiers.org/biomodels.db/MODEL1310110013#_93bd1c06_bfa7_43f1_8be0_67f88252734d
initial amount: NaN
name: ALPP
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: P05187
type: Species
is encoded by: hsa:250
is: SBO:0000252

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM glyald m
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: HMDB01051
constant: false
type: Species
is: CHEBI:17378
name: D-glyceraldehyde
has only substance units: false
initial concentration: 1.0

metaR FAOXC226C225x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaR r2416
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
reversible: false

metaM pmtcrn m
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: HMDB00222
initial concentration: 1.0
constant: false
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
name: L-palmitoylcarnitine
is: SBO:0000247

metaR TSTSTERONEtr
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110013#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
name: testosterone intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110013#_2ae7fc76_db03_4138_9a42_86b4fd785475
name: NDUFS7
type: Species
is: O75251
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:374291
boundary condition: true
has only substance units: false

metaR r2355
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r2202
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
modifier: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
fast: false

metaM acnacngalgbside hs g
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:3338
name: disialyl galactosylgloboside
is: HMDB00223
boundary condition: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: SBO:0000247
is: C00036
type: Species
initial amount: NaN

metaM amet r
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15414
type: Species
constant: false
name: S-adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial amount: NaN
initial concentration: 1.0
is: HMDB01185

metaM dhap x
boundary condition: false
is: http://identifiers.org/pubchem.compound/3411
is: C00111
name: Dihydroxyacetone phosphate
is: CHEBI:57642
initial concentration: 1.0
is: HMDB01473
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR r1487
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true
name: EC:6.2.1.3
reactant: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
type: Reaction
fast: false

metaR NACHEX13ly
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaR C204CRNt
type: Reaction
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
name: arachidonic acid transport into the mitochondria
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_8e856b0b_e151_4d4a_b6c9_1839c323ca9f
is: Q9H0I9
boundary condition: true
is encoded by: hsa:84076
initial amount: NaN
initial concentration: NaN
name: TKTL2
is: SBO:0000252
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_28367a4e_a89c_4f33_af0d_c35f29da4878
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PYCRL
constant: false
type: Species
is: Q53H96
boundary condition: true
is encoded by: hsa:65263
initial concentration: NaN

metaM fuc L e
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00174
is: SBO:0000247
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
name: L-fucose
constant: false
is: CHEBI:18287

http://identifiers.org/biomodels.db/MODEL1310110013#_c5fccfc5_6a78_44cb_b0ed_be3b9e2ee472
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: O15244
initial concentration: NaN
is encoded by: hsa:6582
is: SBO:0000252
name: SLC22A2

http://identifiers.org/biomodels.db/MODEL1310110013#_4f1a6cb8_93b8_4737_b5ef_860ad39c936e
is: Q6IB54
is encoded by: hsa:522
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: ATP5J
constant: false
initial amount: NaN
boundary condition: true

metaM CE0713 m
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB02329
name: 3-oxolinoleoyl-CoA
is: CHEBI:30623
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
boundary condition: false
initial concentration: 1.0

metaR r2356
fast: false
is: SBO:0000185
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_7b1a7b17_62ec_4676_a0e2_c9faef979e87
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: B3KQH0
type: Species
initial concentration: NaN
is encoded by: hsa:55343
constant: false
name: SLC35C1
boundary condition: true

metaM crn c
initial amount: NaN
is: CHEBI:16347
is: C00318
has only substance units: false
boundary condition: false
is: HMDB00062
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR URCN
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: URCN
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.49
modifier: MODEL1310110013#
reversible: false
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_175bbfa0_e084_463b_ba27_186a23249a2a
is: SBO:0000252
initial concentration: NaN
name: SLC25A10
type: Species
is encoded by: hsa:1468
constant: false
has only substance units: false
initial amount: NaN
is: Q9UBX3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_9cd2ea2e_0248_45f1_b09e_a068cf2449b6
name: PIP5K1A
initial amount: NaN
is: Q99755
is encoded by: hsa:8394
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7758e11c_90c4_4fd0_89c7_521b7df15afa
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: CHKB
constant: false
initial concentration: NaN
is: A0PJM6
type: Species
is encoded by: hsa:1120

http://identifiers.org/biomodels.db/MODEL1310110013#_033ae765_6159_46d4_a4f4_0a627c69e810
initial amount: NaN
name: ITPKB
constant: false
type: Species
is: SBO:0000252
is: P27987
has only substance units: false
is encoded by: hsa:3707
boundary condition: true
initial concentration: NaN

metaR RE2799C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
reversible: true
is: SBO:0000176
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#
fast: false
name: RE2799

metaR OCCOAtm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: false
name: Octanoyl-CoA transport, diffusion
fast: false
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000

metaM 3docopencoa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
type: Species
name: 3,7,10,13,16-docosapentenoylcoa
initial amount: NaN

metaR r0780
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_dfd68c22_bdc0_4b60_a421_ba5446282ac5
constant: false
is: Q8N0X4
initial amount: NaN
initial concentration: NaN
type: Species
name: CLYBL
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:171425

metaR FACOAL181i
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reversible: false
fast: false
name: C181 fatty acid activation
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR FAOXC80
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
name: Beta oxidation of med/long chain fatty acid
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction

metaR FAOXC2251836m
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
modifier: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#

metaR r1600
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110013#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000000

metaM acnacngalgbside hs e
constant: false
is: C00036
boundary condition: false
type: Species
name: disialyl galactosylgloboside
is: CHEBI:3338
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: HMDB00223
is: SBO:0000247

metaM hs deg5 l
is: CHEBI:17895
constant: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
name: heparan sulfate, degradation product 5
has only substance units: false
is: SBO:0000247
is: HMDB00158

http://identifiers.org/biomodels.db/MODEL1310110013#_392ad006_a826_4418_8dae_9b7ee5f416c8
constant: false
is: B8ZZR8
initial amount: NaN
is: SBO:0000252
type: Species
name: GGCT
has only substance units: false
is encoded by: hsa:79017
boundary condition: true
initial concentration: NaN

metaM urea c
is: SBO:0000247
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: CHEBI:16199
name: Urea
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00294
is: C00086
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_195232b5_24cc_42e8_b9f5_5642bdbe4c0f
constant: false
is: P04746
initial concentration: NaN
name: AMY2A
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:279

http://identifiers.org/biomodels.db/MODEL1310110013#_b94c78d3_e0b8_410e_85b2_3088d23fe2b4
is encoded by: hsa:6785
boundary condition: true
is: Q9GZR5
initial amount: NaN
name: ELOVL4
has only substance units: false
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR GTMLTe
name: g-glutamyltransferase (e)
modifier: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (2679.1) or (2678.1) or (2678.3) or (2678.2) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:15469854 NOTES:NCD SAB e see Disussion section of PMID 15469854
reversible: false
is version of: http://identifiers.org/ec-code/2.3.2.2
fast: false
product: MODEL1310110013#
is: SBO:0000185

metaR UDPGLCAter
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110013#
product: MODEL1310110013#
reversible: true
is: SBO:0000185
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
kinetic law: MODEL1310110013#

metaR GMPtg
reversible: true
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
kinetic law: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000269
name: GMP transport (Golgi)

metaM fol c
name: Folate
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00121
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR S6TASE15ly
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110013#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110013#
fast: false

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_16846c98_00df_40cb_bf84_645fbf132514
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3032
type: Species
is: P55084
name: HADHB
initial amount: NaN
constant: false

metaR FAOXC101C102m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_eaf50763_eb5d_482c_94ba_0b79cff58359
name: AK2
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:204
initial amount: NaN

metaR FAOXC183806m
modifier: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110013#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
is described by: ECO:0000269
kinetic law: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_bc86db26_182a_4b19_994d_df8edd87903a
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: MYO5B
is: Q9H6Y6
is encoded by: hsa:4645
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_2d9c076c_7860_4f7e_9d99_fd995e9be587
is: SBO:0000252
name: CDIPT
is: A8K3L7
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:10423
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_0391f2ac_07b2_456a_93d1_78b9758b34a7
type: Species
is: P31213
is: SBO:0000252
name: SRD5A2
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:6716
initial concentration: NaN
boundary condition: true

metaR r1602
reactant: MODEL1310110013#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_627e7570_aae1_4475_bacb_11864f8e5fa5
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1347
has only substance units: false
name: COX7A2
type: Species
is: H0UI06

metaM xtsn c
is: HMDB00299
has only substance units: false
constant: false
boundary condition: false
name: xanthosine
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: SBO:0000247
is: CHEBI:18107

http://identifiers.org/biomodels.db/MODEL1310110013#_726709cb_5d95_4cfa_a930_1dd591c7526e
name: ACLY
is encoded by: hsa:47
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: P53396
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_0894c485_dc7a_40ff_86c8_1b0a9e42c13c
is: SBO:0000252
boundary condition: true
name: COX2
initial amount: NaN
is encoded by: hsa:4513
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: Q7GXZ8

metaM acnacngalgbside hs c
is: HMDB00223
is: SBO:0000247
boundary condition: false
name: disialyl galactosylgloboside
type: Species
constant: false
has only substance units: false
is: C00036
is: CHEBI:3338
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial amount: NaN

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM glx c
is: HMDB00119
name: glyoxylate
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
is: CHEBI:36655
boundary condition: false

metaR ADPtx
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
is described by: ECO:0000000
name: ADP transporter, peroxisomal
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110013#
fast: false

metaM urea e
boundary condition: false
is: SBO:0000247
name: Urea
is: C00086
type: Species
constant: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial concentration: 1.0
is: CHEBI:16199
has only substance units: false
is: HMDB00294
initial amount: NaN

metaM fol e
boundary condition: false
is: HMDB00121
name: Folate
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7bd1a313_f14d_4648_8b09_b837336639f4
has only substance units: false
constant: false
is: Q93099
name: HGD
is: SBO:0000252
is encoded by: hsa:3081
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR r1603
reversible: true
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_8748bbde_516a_49ac_8d5c_cf1ce2030e35
is encoded by: hsa:3613
initial concentration: NaN
is: SBO:0000252
name: IMPA2
constant: false
is: O14732
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_d02a7efa_7466_43a9_836c_1e1008c82a33
boundary condition: true
is encoded by: hsa:441024
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: Q9H903
initial concentration: NaN
initial amount: NaN
name: MTHFD2L

http://identifiers.org/biomodels.db/MODEL1310110013#_9b2348cc_878b_483d_a6af_d73bd8fe2ebf
type: Species
is: A7E2E5
is encoded by: hsa:5140
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: PDE3B
is: SBO:0000252

metaM 2mb2coa m
initial concentration: 1.0
is: HMDB02054
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57337
has only substance units: false
name: 2-methylcrotonoyl-CoA(4-)
boundary condition: false

metaR RE2660C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
name: RE2660
is: SBO:0000176
kinetic law: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#

metaM ps hs e
is: SBO:0000247
name: phosphatidylserine
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:18303
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_8bae2fec_0d7e_4471_b17c_b2ec6f2451e1
is: SBO:0000252
is: P50213
constant: false
initial concentration: NaN
initial amount: NaN
name: IDH3A
boundary condition: true
has only substance units: false
is encoded by: hsa:3419
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_348aade5_844f_43c3_aee5_90bf80006c67
has only substance units: false
initial concentration: NaN
name: SGPP1
type: Species
is: Q9BX95
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:81537
boundary condition: true

metaM udpacgal c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
constant: false
boundary condition: false
is: CHEBI:57847
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
initial amount: NaN
type: Species

metaM tdcoa x
is: C02593
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01521
is: SBO:0000247
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: CHEBI:57385
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110013#_2bff8045_6556_4f7b_81eb_a3e504ed1d42
boundary condition: true
type: Species
name: SLC27A1
is: Q6PCB7
is encoded by: hsa:376497
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r1604
product: MODEL1310110013#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM ksi deg28 l
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: HMDB01354
name: keratan sulfate I, degradation product 28
is: CHEBI:57455
is: SBO:0000247
notes: FORMULA: C104H170N7O85S3 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110013#_fbdc9ad0_dd20_469c_8fee_17cbd210144b
boundary condition: true
type: Species
is encoded by: hsa:384
name: ARG2
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P78540
constant: false
initial amount: NaN

metaR FAOXC61x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_e209fe22_9cb1_49fc_8fbb_a347ae7a65ee
initial amount: NaN
is encoded by: hsa:4714
boundary condition: true
initial concentration: NaN
name: NDUFB8
has only substance units: false
constant: false
is: O95169
is: SBO:0000252
type: Species

metaR FAOXC226C225m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaM dcsptn1coa x
boundary condition: false
is: HMDB06513
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
type: Species
is: http://identifiers.org/pubchem.compound/47205483
has only substance units: false
constant: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173

http://identifiers.org/biomodels.db/MODEL1310110013#_e38ae77c_202d_4593_95e7_1bd0145d6b7b
type: Species
constant: false
initial amount: NaN
name: _AA177072_1_x
initial concentration: NaN
is encoded by: hsa:AA177072
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM omhpal c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB06294
name: w-hydroxypalmiticacid
notes: FORMULA: C16H30O3 CHARGE: -1
boundary condition: false
has only substance units: false
type: Species

metaR r1605
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_0fe47b0b_7ab8_4e1e_b913_a66151a3bfaf
name: GBA
has only substance units: false
is: B7Z5G2
initial amount: NaN
is encoded by: hsa:2629
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false

metaM pre prot r
boundary condition: false
has only substance units: false
is: CHEBI:16240
constant: false
initial concentration: 1.0
type: Species
name: glycophosphatidylinositol (GPI)-anchored protein precursor
notes: FORMULA: XY CHARGE: 0
is: HMDB03125
is: SBO:0000247
initial amount: NaN

metaM glyald c
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
name: D-Glyceraldehyde
is: C00577
is: HMDB01051

metaR PPDOx
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110013#_d70985cc_008e_46fe_983d_47af1a360463
has only substance units: false
initial concentration: NaN
name: UCK2
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: Q9BZX2
boundary condition: true
is encoded by: hsa:7371

metaM gly x
boundary condition: false
is: CHEBI:15428
initial amount: NaN
is: HMDB00123
has only substance units: false
name: glycine
is: SBO:0000247
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
constant: false
initial concentration: 1.0

metaR NAIt
type: Reaction
is described by: ECO:0000269
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
name: Na+ / iodide cotransport
modifier: MODEL1310110013#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaR GLCNACASE1ly
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_9d5c6cf1_f425_4ade_a3a6_b998d073cfbd
name: NDUFA4L2
is encoded by: hsa:56901
type: Species
is: SBO:0000252
is: Q9NRX3
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r1606
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r2420
reactant: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reversible: true
type: Reaction

metaR PPDOy
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
reversible: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110013#
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_e5b31593_ab81_4715_99d1_26b353ecd382
boundary condition: true
name: DGUOK
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:1716
is: E5KSL6
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_bd41eb97_dd5a_4fc3_a381_8811ce8310cc
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: BDH1
is encoded by: hsa:622
constant: false

metaR PYDXNtr
name: pyridoxine transport via diffusion
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT
reversible: true

metaR ACNMLr
is: SBO:0000176
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110013#
is described by: ECO:0000000
name: N-Acetylneuraminate lyase (reversible)

http://identifiers.org/biomodels.db/MODEL1310110013#_62eed60b_daf4_4586_80f5_173a5b6d2f11
is encoded by: hsa:5295
has part: P27986
initial amount: NaN
type: Species
name: PIK3CA:PIK3R1
is: SBO:0000297
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

metaR r1607
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
kinetic law: MODEL1310110013#
reversible: true

metaR r0226
type: Reaction
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reversible: false
fast: false
reactant: MODEL1310110013#

metaR CYSTA
reactant: MODEL1310110013#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
reversible: true
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
name: cysteine transaminase
modifier: MODEL1310110013#

metaR MI1345PP
is version of: http://identifiers.org/ec-code/3.1.3.36
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86
reactant: MODEL1310110013#
product: MODEL1310110013#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase

metaM acac m
boundary condition: false
is: CHEBI:13705
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
is: SBO:0000247
name: acetoacetate
is: HMDB00060
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM dutp m
boundary condition: false
is: SBO:0000247
is: CHEBI:17625
has only substance units: false
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191
initial concentration: 1.0
initial amount: NaN
name: dUTP
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_d727fcaf_61f7_46a0_aec8_a5f366d3b285
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: PAPSS1
is encoded by: hsa:9061
is: O43252
has only substance units: false
constant: false

metaM dhap c
boundary condition: false
is: HMDB01473
initial amount: NaN
constant: false
is: CHEBI:57642
is: C00111
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411
name: Dihydroxyacetone phosphate
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_8f96843c_5962_4ac0_b2b6_21d034b65a4c
type: Species
has only substance units: false
boundary condition: true
name: GMPR
is encoded by: hsa:2766
constant: false
is: P36959
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_a67c7452_2262_454f_b009_cfca6c765e7a
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC6A2
is encoded by: hsa:6530
boundary condition: true
constant: false
is: Q96KH8
type: Species

metaR SPC HSt
name: sphingosylphosphorylcholine transport (diffusion)
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_b15099f1_66e4_45a5_a906_12213fd3cc7f
type: Species
is: SBO:0000252
has only substance units: false
name: NADSYN1
boundary condition: true
constant: false
is encoded by: hsa:55191
is: Q6IA69
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_66361542_ae5f_499a_8360_64d1a008dc35
boundary condition: true
is: SBO:0000252
type: Species
is: O75947
has only substance units: false
initial concentration: NaN
name: ATP5H
is encoded by: hsa:10476
constant: false
initial amount: NaN

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR FAOXC102C81m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR URAt
type: Reaction
name: uracil transport via facilated diffusion
modifier: MODEL1310110013#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaM glutcoa m
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57378
type: Species
name: glutaryl-CoA(5-)
boundary condition: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: SBO:0000247
is: HMDB01339

metaR MALTe
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.20
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
reversible: false
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
type: Reaction
name: alpha-glucosidase, extracellular

http://identifiers.org/biomodels.db/MODEL1310110013#_09532f75_f834_4448_a460_e4da7edb95b4
boundary condition: true
is: SBO:0000252
constant: false
name: SLC6A9
is: P48067
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:6536

metaR DRIBt
name: deoxyribose transport via diffusion
fast: false
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_fdf3ea1d_b32b_4ba2_a4c4_efb9e8091e96
has only substance units: false
is encoded by: hsa:7498
name: XDH
initial concentration: NaN
constant: false
type: Species
is: P47989
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM udpacgal g
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847

metaR PEPCK
reactant: MODEL1310110013#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.1.1.32
name: Phosphoenolpyruvate carboxykinase (GTP)
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: false
type: Reaction
fast: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (5105.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:17211624,PMID:17888579,PMID:17888580,PMID:8325643 NOTES:17888579 - kinetic characterization of human cytosolic form; 8325643 - homology to rat; 17211624 - immunohistochemistry for expression
is: SBO:0000176

metaM dcholcoa c
is: SBO:0000247
name: chenodeoxycholoyl coenzyme a
type: Species
is: CHEBI:28701
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB06292
boundary condition: false
initial amount: NaN

metaM dhap e
has only substance units: false
name: glycerone phosphate(2-)
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57642
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01473

metaR FACOAL1831
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
name: fatty-acid--CoA ligase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM 4hexdtetcoa x
initial concentration: 1.0
has only substance units: false
is: HMDB02288
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 4,7,10,13-hexadecatetraenoylcoa

metaR RPE
reactant: MODEL1310110013#
name: ribulose 5-phosphate 3-epimerase
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is described by: ECO:0000000
product: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/5.1.3.1
is: SBO:0000176

metaR TALA
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
is: SBO:0000176
modifier: MODEL1310110013#
name: transaldolase
is described by: ECO:0000000
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.2
product: MODEL1310110013#
reversible: true

metaM nrvnccoa c
type: Species
is: C16532
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: nervonyl coenzyme A
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1

metaM gacpail hs c
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: HMDB01401
boundary condition: false
type: Species
has only substance units: false
is: C00092
is: CHEBI:61548
initial concentration: 1.0
name: glucosaminyl-acylphosphatidylinositol
constant: false

metaR FAOXC61m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR GDPFUCtg
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
is: SBO:0000185
fast: false
product: MODEL1310110013#
name: GDPFuc Golgi transport via CMP antiport
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_967b3750_1c56_4128_9544_835cdc09baa5
is encoded by: hsa:10050
is: SBO:0000252
initial concentration: NaN
is: Q9Y2C5
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: SLC17A4
type: Species

metaM 3docopencoa m
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: 3,7,10,13,16-docosapentenoylcoa
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false

metaR LPS2e
is: SBO:0000176
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
reactant: MODEL1310110013#
fast: false
type: Reaction
name: lipase, extracellular
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.1.3
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110013#

metaM 4mlacac c
is: HMDB02052
type: Species
is: CHEBI:17105
name: 4-maleylacetoacetate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
constant: false
initial amount: NaN

metaM hyptaur c
name: Hypotaurine
type: Species
is: HMDB00965
is: SBO:0000247
constant: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
initial amount: NaN
has only substance units: false
is: CHEBI:16668
initial concentration: 1.0
boundary condition: false

metaR FACOAL1832
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
reactant: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110013#
modifier: MODEL1310110013#
name: fatty-acid--CoA ligase
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_4db50a45_2f3f_4231_946f_9f80864812d9
name: GNMT
initial concentration: NaN
is: Q14749
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:27232

metaM dolmanp L r
is: CHEBI:15809
type: Species
name: Dolichyl phosphate D-mannose, human liver homolog
boundary condition: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_a5fbc431_76aa_4c7e_af96_3aa330efe7df
type: Species
is: SBO:0000252
initial amount: NaN
is: C9JT23
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: NDUFA11
is encoded by: hsa:126328

metaR ACOAD10m
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000269
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
modifier: MODEL1310110013#
type: Reaction
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
reactant: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176

metaM udpacgal l
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57847
type: Species
boundary condition: false
constant: false
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial amount: NaN
is: HMDB00304

metaM xol7ah2al m
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: HMDB06894
is: CHEBI:27428
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: SBO:0000247
initial concentration: 1.0

metaM tre e
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
is: HMDB00975
is: CHEBI:16551
initial concentration: 1.0
boundary condition: false
name: Trehalose
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: C01083

metaR GGT6
fast: false
product: MODEL1310110013#
name: Gamma-glutamyltransferase
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reactant: MODEL1310110013#

metaM Ser Gly Ala X Gly l
is: CHEBI:36005
initial amount: NaN
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: HMDB02183
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
boundary condition: false
type: Species
constant: false

metaR P4502F1
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.14.1
notes: GENE_ASSOCIATION: (1572.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107,PMID:1974816 NOTES:naphthalene epoxidation assumed to take place on outer membrane NJ
is described by: ECO:0000269
modifier: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
reversible: false
is: SBO:0000176
name: cytochrome P450 2F1

http://identifiers.org/biomodels.db/MODEL1310110013#_2bc16dad_83b0_4f8d_ab6a_bed921dabce4
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q68CJ7
is encoded by: hsa:131669
constant: false
name: UROC1

metaM 34dhmald m
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7903
has only substance units: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
name: 3,4-Dihydroxymandelaldehyde
initial concentration: 1.0
is: C05577
is: HMDB06242

http://identifiers.org/biomodels.db/MODEL1310110013#_b2738d26_f695_4e66_8a63_9084b3685088
type: Species
constant: false
has only substance units: false
is: Q8TCG5
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:126129
name: CPT1C
boundary condition: true

metaR CREATt4 2 r
is: SBO:0000185
fast: false
is described by: ECO:0000269
modifier: MODEL1310110013#
product: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
name: Creatine transport (sodium symport) (2:1)
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR ALCD21 L
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.99.24
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.1
name: alcohol dehydrogenase (L-1,2-propanediol)
kinetic law: MODEL1310110013#
is: SBO:0000176
reversible: false
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reactant: MODEL1310110013#

metaM ps hs m
initial concentration: 1.0
constant: false
is: CHEBI:18303
is: SBO:0000247
name: ps_hs[m]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

metaR ARACHCPT1
fast: false
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
modifier: MODEL1310110013#
product: MODEL1310110013#

metaR r1262
reversible: false
fast: false
type: Reaction
name: EC:6.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR ARAB Lt
is: SBO:0000185
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
name: L-arabinoase extracellular transport

metaR DSAT
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: dihydrosphingosine N-acyltransferase

metaR FAOXC185C164m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR ACACT5p
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110013#
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
reactant: MODEL1310110013#
reversible: false
fast: false
modifier: MODEL1310110013#

metaR r0670
reversible: false
kinetic law: MODEL1310110013#
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is: SBO:0000176
type: Reaction
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_909fa9f3_0699_49fc_b338_4f8905c672a5
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: PRDX1
is encoded by: hsa:5052
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_52e065ec_51ab_423e_857e_9906501cbc38
is: Q99643
name: SDHC
is encoded by: hsa:6391
type: Species
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR ARACHCPT2
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110013#
fast: false
name: carnitine transferase
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaR ME2m
reversible: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.40
name: malic enzyme (NADP), mitochondrial
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.38
kinetic law: MODEL1310110013#

metaR RPI
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: ribose-5-phosphate isomerase
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.6
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_b9f9f9bd_329f_4fa1_9acd_821237c4e9bc
is encoded by: hsa:2653
is encoded by: hsa:2731
type: Species
constant: false
has part: P09622
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000297
name: DLD:GCSH:GLDC:AMT
has part: P23378
is encoded by: hsa:275
boundary condition: true
has part: P23434
has part: P48728
is encoded by: hsa:1738

metaM 3hibutcoa m
is: HMDB01052
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:28259
boundary condition: false
name: (S)-3-Hydroxyisobutyryl-CoA
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000

metaR ACOAO7p
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
product: MODEL1310110013#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal

http://identifiers.org/biomodels.db/MODEL1310110013#_d1f006a6_e7f4_4dd1_9b86_5af8b7dbf183
is: P15291
initial concentration: NaN
is: SBO:0000252
name: B4GALT1
is encoded by: hsa:2683
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_c3ae9d29_baa3_4bac_855e_a698bbef6b20
name: SOD1
is: P00441
initial concentration: NaN
is encoded by: hsa:6647
constant: false
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_f6f9c2c9_f275_49d7_8e88_a650c9bec80d
constant: false
initial concentration: NaN
is: P16219
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:35
type: Species
name: ACADS
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_595017b7_5d7f_4102_8f19_f6e48cdd47c9
has only substance units: false
is encoded by: hsa:AA854479
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: _AA854479_1_m

metaR CDSm
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
name: phosphatidate cytidylyltransferase
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.7.41
is described by: ECO:0000000
reversible: false

metaM fdp c
name: D-Fructose 1,6-bisphosphate
is: HMDB01058
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3647
constant: false
is: C00354
is: CHEBI:16905
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
type: Species
has only substance units: false

metaR r0339
is: SBO:0000176
modifier: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.2.22
is described by: ECO:0000000
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
fast: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_8ea6bedd_2eb2_4794_8e55_46a40a0d2d96
initial amount: NaN
constant: false
name: LHPP
has only substance units: false
boundary condition: true
is: Q9H008
is: SBO:0000252
is encoded by: hsa:64077
type: Species
initial concentration: NaN

metaM tdcoa m
initial concentration: 1.0
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
boundary condition: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
constant: false
is: C02593
is: HMDB01521
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57385

metaM HC01403 m
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
initial amount: NaN
is: CHEBI:28325
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: (S)-Hydroxydecanoyl-CoA
has only substance units: false

metaM hexe3coa m
boundary condition: false
has only substance units: false
type: Species
constant: false
name: 3-hexenoylcoa
is: HMDB06522
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_1cc409d8_6d97_431b_8a0e_6b60bd7d4f3a
boundary condition: true
initial amount: NaN
name: EARS2
constant: false
is: Q5JPH6
is encoded by: hsa:124454
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_0b79feb1_1052_492a_8516_0c83effbac0c
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110013#_1c1056b4_5459_413e_9d69_a14eef8a8837
is: Q9NQU1
is: SBO:0000252
initial amount: NaN
name: SLC26A6
is encoded by: hsa:65010
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_8b6d4a39_2600_47e8_8ad8_67a68e54bfcb
name: ADCY5
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O95622
type: Species
is encoded by: hsa:111
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_014ae578_03d1_4773_96aa_e34079887163
boundary condition: true
is encoded by: hsa:51022
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: GLRX2

metaM ksi deg29 l
has only substance units: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
initial concentration: 1.0
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 29
is: HMDB00143
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ad358b0c_5cb9_4ebf_ab7f_d4d05a5dcbf0
name: ACOT2
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is: P49753
initial concentration: NaN
is encoded by: hsa:10965

metaM octe5coa x
is: http://identifiers.org/pubchem.compound/16019966
name: 5-octenoylcoa
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
constant: false
boundary condition: false
is: SBO:0000247

metaM succoa m
name: Succinyl-CoA
constant: false
is: HMDB01022
initial concentration: 1.0
has only substance units: false
is: CHEBI:57292
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
boundary condition: false
initial amount: NaN
type: Species

metaR LINKDEG4ly
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110013#
reversible: false
fast: false
name: degradation of proteoglycan linkage region, lysosomal
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR FAOXC181C161x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR OCTAt
type: Reaction
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
fast: false
name: Octanoate transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR

metaR GALT
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
name: galactose-1-phosphate uridylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.12

metaR PI4PLC
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000269
fast: false
name: phosphatidylinositol 4-phosphate phospholipase C

http://identifiers.org/biomodels.db/MODEL1310110013#_2dc2331e_b49a_480e_ab57_7c59e0ec5862
is encoded by: hsa:226
initial concentration: NaN
type: Species
name: ALDOA
constant: false
is: P04075
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_f2a3d804_f8b5_48d6_a136_98b912e09037
is encoded by: hsa:6515
is: P11169
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC2A3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_2f4c6c29_9cf4_4a65_a1c5_ab0b3682516d
is: SBO:0000252
boundary condition: true
is encoded by: hsa:767
is: P35219
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: CA8
constant: false

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
constant: false
is: CHEBI:57795
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_40029980_70d3_4de3_b849_1fface9a6015
type: Species
initial concentration: NaN
is encoded by: hsa:51727
is: B2R6S5
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: CMPK1

http://identifiers.org/biomodels.db/MODEL1310110013#_4f5edc18_f28c_482b_bed7_fb986a9b2337
is: SBO:0000252
is encoded by: hsa:80055
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q75T13
name: PGAP1

metaR NDP3ex
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
fast: false
name: nucleoside-diphosphatase (GDP), extracellular
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
is described by: ECO:0000269
type: Reaction

metaM gua e
boundary condition: false
is: HMDB00132
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16235
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
type: Species
name: guanine

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaR GALU
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
type: Reaction
name: UTP-glucose-1-phosphate uridylyltransferase
reactant: MODEL1310110013#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.7.9
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
product: MODEL1310110013#

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR r2369
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185

metaR FAOXC165C164m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR PAIL4P HStn
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
type: Reaction
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110013#

metaM drib e
name: 2-deoxy-D-ribose
constant: false
has only substance units: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
initial amount: NaN
is: HMDB03224
initial concentration: 1.0
boundary condition: false
is: CHEBI:28816
type: Species
is: SBO:0000247

metaR r0650
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.1.1.36
is described by: ECO:0000000
modifier: MODEL1310110013#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reversible: true
fast: false
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaR ACACT7p
reversible: false
is: SBO:0000176
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is described by: ECO:0000269
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_8fe0a71d_f7bc_4a5e_a8cb_880c8b72157e
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _LOC727762_1_m
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:LOC727762

http://identifiers.org/biomodels.db/MODEL1310110013#_39b1d711_8d3f_444c_88a9_e51230d022a1
is: SBO:0000252
initial amount: NaN
constant: false
name: TXNRD1
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:7296
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_d65d67b0_0616_409e_acf5_56f0c49ed94d
is encoded by: hsa:122481
boundary condition: true
type: Species
initial amount: NaN
name: AK7
is: SBO:0000252
is: Q96M32
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_d494c69b_b077_42ca_905a_264e7e261b51
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: E7ETH5
name: SLC13A2
boundary condition: true
has only substance units: false
is encoded by: hsa:9058
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_53ddea35_8d6f_4a6a_a8e4_4a71312859cc
constant: false
is: SBO:0000252
type: Species
is: P23786
initial amount: NaN
boundary condition: true
name: CPT2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1376

metaM ksi deg31 l
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
name: keratan sulfate I, degradation product 31
has only substance units: false
boundary condition: false
is: CHEBI:57455
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01354
is: SBO:0000247
constant: false

metaR r0651
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
reversible: true
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction

metaR UDPG4E
fast: false
name: UDPglucose 4-epimerase
reversible: true
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/5.1.3.2
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000134

metaM gua c
is: CHEBI:16235
initial concentration: 1.0
type: Species
is: HMDB00132
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
boundary condition: false
name: Guanine
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: C00242

metaM 4abut m
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
name: 4-Aminobutanoate
has only substance units: false
is: C00334
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00112
constant: false
initial concentration: 1.0
is: CHEBI:16865
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_916bc237_10ff_4e2f_9480_f0f5ed98f56a
constant: false
name: GBA
is: B7Z6S9
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2629
has only substance units: false

metaR FACOAL1813
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
name: fatty-acid--CoA ligase
is described by: ECO:0000269

metaR r0652
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is described by: ECO:0000000
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110013#
fast: false
reversible: true
is: SBO:0000176
type: Reaction

metaM drib c
has only substance units: false
is: CHEBI:28816
name: 2-deoxy-D-ribose
type: Species
initial concentration: 1.0
is: HMDB03224
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247

metaM 2hb c
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
constant: false
name: 2-Hydroxybutyrate
initial concentration: 1.0
is: CHEBI:1148
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00008

http://identifiers.org/biomodels.db/MODEL1310110013#_1af5fcd2_d830_45d1_b9c8_dca4cfa01e10
is: SBO:0000297
name: ADH1A:ADH1B
constant: false
type: Species
has only substance units: false
has part: P07327
boundary condition: true
initial amount: NaN
is encoded by: hsa:124
initial concentration: NaN

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_caf94702_f652_4679_91bd_3e33490638eb
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55902
name: ACSS2
is: Q5QPH3
constant: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_58a5336f_a2c4_491a_9eea_c74e8e3bc4ff
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:50484
boundary condition: true
initial amount: NaN
has only substance units: false
name: RRM2B
is: Q7LG56
constant: false

metaR FACOAL1812
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110013#
type: Reaction
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
is described by: ECO:0000000
name: fatty-acid--CoA ligase

metaM dgmp e
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57673
boundary condition: false
is: HMDB01044
name: dGMP(2-)
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
constant: false
initial concentration: 1.0

metaM mi134p c
boundary condition: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:58414
type: Species
initial amount: NaN
is: HMDB01143
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_828960b1_be53_45b5_a9c7_e7ba0ab1a481
is: SBO:0000252
constant: false
is: B3KT70
has only substance units: false
type: Species
is encoded by: hsa:80201
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: HKDC1

http://identifiers.org/biomodels.db/MODEL1310110013#_43d64414_d732_4627_95e9_8973823d6dfb
is: SBO:0000252
constant: false
boundary condition: true
name: ADSL
initial concentration: NaN
is encoded by: hsa:158
type: Species
has only substance units: false
initial amount: NaN
is: P30566

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR FAOXC161802m
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
reversible: false
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_79deb10d_b54b_4292_8572_9026ca4b256c
is: SBO:0000252
is: Q9H0P0
type: Species
is encoded by: hsa:51251
name: NT5C3
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaR r0653
fast: false
is described by: ECO:0000000
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176
type: Reaction
reversible: false

metaM lnlccoa m
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
boundary condition: false
has only substance units: false
type: Species
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064
initial amount: NaN

metaM pep c
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:18021
is: C00074
is: SBO:0000247
name: Phosphoenolpyruvate
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00263
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074

metaR r1493
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
name: Utilized transport
reversible: false
is: SBO:0000185
reactant: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_c147f226_9d99_4a56_b571_011e2bf0c4a5
is: P18283
is encoded by: hsa:2877
name: GPX2
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaM ksi e
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
initial amount: NaN
is: CHEBI:17268
is: HMDB00211
name: keratan sulfate I
type: Species

metaM 2hb e
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
name: 2-Hydroxybutyrate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:1148
is: HMDB00008
type: Species
is: SBO:0000247
boundary condition: false

metaR UREAtm
reversible: true
fast: false
notes: GENE_ASSOCIATION: (366.1) SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES:JLR SAB m
name: Urea transport via diffusion
kinetic law: MODEL1310110013#
is described by: ECO:0000304
modifier: MODEL1310110013#
is: SBO:0000185
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_618d6f16_1895_40ba_9b0b_83e10d86822f
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: O43306
is encoded by: hsa:112
name: ADCY6
boundary condition: true

metaM dgmp c
constant: false
name: dGMP
is: SBO:0000247
boundary condition: false
is: C00362
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: CHEBI:57673
initial amount: NaN
type: Species
is: HMDB01044
initial concentration: 1.0
has only substance units: false

metaR r0330
is: SBO:0000176
fast: false
type: Reaction
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
reversible: false
reactant: MODEL1310110013#
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_8b509627_711e_454a_b87c_6688e146b21f
boundary condition: true
constant: false
is: Q6LEN5
is encoded by: hsa:1103
name: CHAT
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_47da9d27_1246_433b_a6e5_700b309cded7
is: SBO:0000252
has only substance units: false
constant: false
is: P51570
name: GALK1
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2584

metaR PGDI
kinetic law: MODEL1310110013#
is described by: ECO:0000269
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
type: Reaction
is: SBO:0000176
reactant: MODEL1310110013#
reversible: true
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.5.1.18
name: Prostaglandin-H2 D-isomerase [Precursor]
fast: false
is version of: http://identifiers.org/ec-code/5.3.99.2

metaR r0655
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110013#
type: Reaction
is: SBO:0000176
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
fast: false
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110013#

metaM ha e
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
boundary condition: false
constant: false
is: CHEBI:16336
name: hyaluronan
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0

metaM pa hs m
constant: false
name: phosphatidate(2-)
boundary condition: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_9abb8016_b806_4551_a5dd_1ed282046f54
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: SLC25A13
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:10165
type: Species
is: Q9UJS0

metaR HISTAtu
name: Histamine uniport
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
reactant: MODEL1310110013#
fast: false

metaR BAAT4x
is described by: ECO:0000304
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176
modifier: MODEL1310110013#
name: bile acid Coenzyme A: amino acid N-acyltransferase
reactant: MODEL1310110013#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ

http://identifiers.org/biomodels.db/MODEL1310110013#_c389547b_92e8_4b14_9d10_7b6ee77ac432
is: O43280
name: TREH
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:11181
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_c1bb8bd7_31db_440a_98b4_09301322f612
name: FOLR3
type: Species
initial amount: NaN
constant: false
is: Q05C14
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2352

http://identifiers.org/biomodels.db/MODEL1310110013#_47e9a9ad_39fe_42c9_80c8_0703ef866c62
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:BE042354
name: _BE042354_1_m
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM ksi deg38 l
is: HMDB00143
notes: FORMULA: C54H91N3O41 CHARGE: 0
name: keratan sulfate I, degradation product 38
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:12936
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_9e998828_a631_4cc3_bd88_d914be95a6b1
type: Species
constant: false
is encoded by: hsa:6817
is: SBO:0000252
initial amount: NaN
name: SULT1A1
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_656d9f2d_a978_4c5d_8c15_4e8e792269d6
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:3417
name: IDH1
is: O75874
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM tethex3 c
type: Species
initial concentration: 1.0
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
name: tetracosahexaenoic acid, n-3
is: SBO:0000247
is: HMDB02007

metaR r0656
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
fast: false
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
type: Reaction
reversible: false
is: SBO:0000176

metaR RE1516M
fast: false
name: RE1516
is: SBO:0000176
kinetic law: MODEL1310110013#
reversible: true
type: Reaction
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
is described by: ECO:0000000

metaR ATP2ter
product: MODEL1310110013#
is: SBO:0000185
name: AMP/ATP transporter, endoplasmic reticulum
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reversible: true
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000

metaR D 3AIBt
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
reversible: false
is: SBO:0000185
name: D-3-amino-isobutyrate transport

metaR BIOCYTtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:16011464,PMID:5867120,PMID:7758201,PMID:8593541 NOTES:IT
is: SBO:0000185
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000000
name: biocytin transport, nuclear
kinetic law: MODEL1310110013#
fast: false

metaR r2363
product: MODEL1310110013#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#
name: Organic anion transporter 5 Utilized transport

metaM galacglcgalgluside hs g
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:17103
name: Lc4Cer

metaR CSBPASEly
is described by: ECO:0000000
product: MODEL1310110013#
type: Reaction
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false

metaR RE3243R
is: SBO:0000176
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
is described by: ECO:0000000
name: RE3243
type: Reaction
product: MODEL1310110013#

metaM retinal c
is: CHEBI:15035
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
name: retinal

metaR GALK
is: SBO:0000176
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: false
type: Reaction
kinetic law: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.157
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.6
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
name: galactokinase
is described by: ECO:0000000

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR SERGLYexR
modifier: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#
fast: false
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
name: L-Serine/Glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_854c1cdc_82ea_4cfb_821d_ec5218f3a339
constant: false
is: SBO:0000252
is encoded by: hsa:26290
has only substance units: false
type: Species
name: GALNT8
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9NY28

metaR r2364
fast: false
kinetic law: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110013#
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110013#
is described by: ECO:0000000

metaM 5thf e
name: pentaglutamyl folate (THF)
is: HMDB06487
notes: FORMULA: C39H45N11O18 CHARGE: -6
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaM gthox c
initial amount: NaN
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
has only substance units: false
name: Oxidized glutathione
boundary condition: false
initial concentration: 1.0
is: C00127
is: SBO:0000247
type: Species
is: HMDB03337
is: CHEBI:58297

metaM lnlccoa r
name: linoleic coenzyme A
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
boundary condition: false
is: HMDB01064
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/5462164

http://identifiers.org/biomodels.db/MODEL1310110013#_22f1722e_fd9f_45ad_858d_75bed0dba8fa
type: Species
is: SBO:0000252
is encoded by: hsa:9197
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: O00400
name: SLC33A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_5cc5c5a2_b41c_46de_b645_dd5c49919ddf
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:26
boundary condition: true
has only substance units: false
name: ABP1
is: P19801
constant: false
initial amount: NaN

metaM lac L c
is: HMDB00190
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:16651
name: (S)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177

metaR ORNt3m
fast: false
product: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
name: ornithine mitochondrial transport via proton antiport

metaM octe5coa m
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
name: 5-octenoylcoa
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_9f63912e_3b84_45b9_ab10_f382a6a0d7dd
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: TALDO1
is encoded by: hsa:6888
initial amount: NaN
constant: false
boundary condition: true
is: P37837

http://identifiers.org/biomodels.db/MODEL1310110013#_5f357488_7e9c_4707_bf25_8ef8790ff232
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: P11498
has only substance units: false
initial amount: NaN
type: Species
name: PC
is encoded by: hsa:5091

metaM 2dodtricoa x
initial amount: NaN
boundary condition: false
is: C05279
is: SBO:0000247
name: 2,6,9-dodecatrienoylcoa
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
has only substance units: false
is: HMDB11123
type: Species
initial concentration: 1.0

metaR F1Atg
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
name: F1alpha transport (from golgi to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
type: Reaction

metaR SIAT4Bg
is version of: http://identifiers.org/ec-code/2.4.99.4
fast: false
reversible: false
product: MODEL1310110013#
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
kinetic law: MODEL1310110013#

metaR CLPNDt
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
name: fatty acid transport via diffusion
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_75e585f6_ec34_41e9_bf84_4fed1d6bf8f0
boundary condition: true
name: PIGF:PIGO
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000297
has part: Q8TEQ8
is encoded by: hsa:84720
has part: Q07326
is encoded by: hsa:5281
initial concentration: NaN

metaR HDCAtr
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
name: fatty acid transport via diffusion

metaR r2361
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_9bb62c60_de85_4d41_953b_121ab1518f99
constant: false
initial concentration: NaN
is: P78381
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC35A2
is encoded by: hsa:7355

http://identifiers.org/biomodels.db/MODEL1310110013#_99e17103_a65e_471e_a41b_99f3f79e873d
initial amount: NaN
is: G3XA95
is: SBO:0000252
is encoded by: hsa:8611
type: Species
name: PPAP2A
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM HC01407 m
constant: false
name: (S)-Hydroxyhexanoyl-CoA
is: SBO:0000247
type: Species
is: CHEBI:28276
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
boundary condition: false

metaR EX 5mta LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-S-methyl-5-thioadenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_d53fdb1f_9e3c_43c2_8127_be646ee51871
initial concentration: NaN
is: O14772
name: FPGT
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:8790

metaR DRPA
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
fast: false
reactant: MODEL1310110013#
reversible: false
is described by: ECO:0000000
name: deoxyribose-phosphate aldolase

http://identifiers.org/biomodels.db/MODEL1310110013#_fa52e991_43e8_4cd3_82ca_b1f81b9bd9a1
is encoded by: hsa:2348
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: FOLR1
initial concentration: NaN

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR r2362
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
is: SBO:0000185

metaM CE5126 x
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:12947
constant: false
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5126
name: (2R)-pristanoyl-CoA
initial concentration: 1.0
boundary condition: false

metaM tdcoa c
constant: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
type: Species
initial amount: NaN
is: C02593
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: CHEBI:57385
boundary condition: false
is: HMDB01521
is: SBO:0000247

metaR FAOXC226205m
type: Reaction
name: Beta oxidation of long chain fatty acid
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_44e7215e_9d32_4b6e_93ad_93a1292e5b3c
type: Species
name: LEFTY1
is encoded by: hsa:10637
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: O75610
has only substance units: false
initial amount: NaN

metaM HC02207 c
is: CHEBI:27555
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
boundary condition: false
constant: false
type: Species
name: prostaglandin-c2
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR RE2660N
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
type: Reaction
name: RE2660
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
is described by: ECO:0000000

metaM dgmp m
is: HMDB01044
initial amount: NaN
name: dGMP
is: C00362
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:57673
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_140f9f7f_284e_40b7_b3aa_93ef94853e76
constant: false
initial amount: NaN
name: _AA177072_1_c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA177072
has only substance units: false
type: Species

metaM lac L e
has only substance units: false
is: HMDB00190
name: (S)-lactate
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:16651
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c7ad709e_8cb6_43c4_bd07_9da88b48462b
has only substance units: false
is: SBO:0000252
boundary condition: true
name: SLC6A4
initial amount: NaN
is encoded by: hsa:6532
constant: false
initial concentration: NaN
is: P31645
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_b5c1d9f0_05c8_47a1_8458_ffd4eea7b3fb
name: SLC28A1
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:9154
constant: false
is: SBO:0000252
is: Q96PL7
has only substance units: false

metaR 4NPHSFte
kinetic law: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
type: Reaction
is described by: ECO:0000000
name: xenobiotic transport

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_a669361f_38d9_4dea_8c40_d0523ae5041d
initial amount: NaN
constant: false
is encoded by: hsa:8560
has only substance units: false
type: Species
is: SBO:0000252
name: DEGS1
boundary condition: true
initial concentration: NaN

metaR AKR1C41
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
product: MODEL1310110013#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
reversible: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction
fast: false

metaM dutp c
constant: false
initial concentration: 1.0
has only substance units: false
is: C00460
is: SBO:0000247
name: dUTP
initial amount: NaN
boundary condition: false
is: HMDB01191
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625

metaR TETTET6COAtx
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
reversible: true
name: fatty acid intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185

metaR GALASE13ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110013#
name: beta-galactosidase, lysosomal
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176

metaR RE1527M
name: RE1527
modifier: MODEL1310110013#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true

metaM glyc3p c
is: C00093
boundary condition: false
initial concentration: 1.0
name: Glycerol 3-phosphate
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57597

http://identifiers.org/biomodels.db/MODEL1310110013#_b2a3e369_f910_471d_844b_ace1990f39d4
constant: false
has only substance units: false
is encoded by: hsa:114799
name: ESCO1
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: Q5FWF5

metaM tchola x
is: HMDB00036
has only substance units: false
initial amount: NaN
name: taurocholate
is: CHEBI:36257
boundary condition: false
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

metaM HC02207 e
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
has only substance units: false
name: prostaglandin-c2
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:27555
is: SBO:0000247
initial amount: NaN

metaR PROSTGD2t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
fast: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
is: SBO:0000185
reversible: true
name: prostaglandin transport via bicarbonate countertransport
type: Reaction

metaR ALAt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110013#
is described by: ECO:0000304
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: L-alanine reversible transport via proton symport
fast: false
reactant: MODEL1310110013#
type: Reaction
is: SBO:0000185
reversible: true

metaM CE2417 m
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB11123
initial concentration: 1.0
is: CHEBI:28387
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_481c92b5_f59d_4997_bd9a_f5bda04adaad
name: NT5C2
boundary condition: true
is encoded by: hsa:22978
is: P49902
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false

metaR r2368
product: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110013#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

metaM tethex3 e
constant: false
name: tetracosahexaenoic acid, n-3
is: HMDB02007
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR r0931
is described by: ECO:0000000
product: MODEL1310110013#
reversible: false
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110013#
type: Reaction
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_69de9a26_b2bf_4c6f_a909_b9c3514b1643
name: AMT
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:275
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P48728
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_c847e16e_d111_4df0_b636_87ea569e1447
is: SBO:0000252
boundary condition: true
name: CS
initial amount: NaN
is encoded by: hsa:1431
constant: false
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_dde00893_367b_4b9d_b0f3_88cb358b6e20
is encoded by: hsa:34
initial amount: NaN
boundary condition: true
name: ACADM
initial concentration: NaN
is: P11310
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaM Lcystin c
name: L-cystine
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00192
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:16283
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_cc3ebd8c_1cb8_4d15_8101_00bc2dbe8538
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: ITPKC
type: Species
is: Q96DU7
is encoded by: hsa:80271
initial concentration: NaN
boundary condition: true

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_45043be0_8c90_4b93_8b25_8806530c3f38
name: B4GALT2
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:8704
is: SBO:0000252
initial concentration: NaN
is: O60909
has only substance units: false
boundary condition: true

metaR DHAAt1r
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
is: SBO:0000185
type: Reaction
name: dehydroascorbate transport (uniport)
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
fast: false
is described by: ECO:0000269

metaM 4aphdob c
initial concentration: 1.0
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial amount: NaN
is: HMDB00978
constant: false
has only substance units: false
type: Species
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: SBO:0000247
is: CHEBI:58147
boundary condition: false

metaR r2365
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR H2MTer L
name: H2 mannosyltransferase, endoplasmic reticulum
modifier: MODEL1310110013#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000176
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
reversible: false

metaR r0932
reversible: true
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110013#
name: Transport reaction
is described by: ECO:0000000
reactant: MODEL1310110013#

metaM gacpail hs r
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:61548
is: HMDB01401
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
is: C00092

metaM 6thf e
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
is: http://identifiers.org/pubchem.compound/169691
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
name: hexaglutamyl folate (THF)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_5de86313_ae01_4fd4_a6e6_76179eb4d8bf
boundary condition: true
constant: false
is encoded by: hsa:2572
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: GAD2
is: Q5VZ30
initial amount: NaN

metaM oaa m
is: C00036
is: CHEBI:16452
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: SBO:0000247
is: HMDB00223
name: Oxaloacetate
has only substance units: false

metaR S3TASE2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110013#
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction

metaR r2366
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_7a991fe2_b108_4c2c_b055_1570c58b6998
name: PKLR
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5313
boundary condition: true
constant: false
is: P30613

metaR MCLOR
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
name: 3-Mercaptolactate:NAD+ oxidoreductase
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
modifier: MODEL1310110013#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110013#_6b20adf1_65bb_4d1b_9942_414d1865a2f6
initial amount: NaN
is encoded by: hsa:3032
type: Species
is: P55084
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: HADHB
boundary condition: true

metaR ORNLEUrBATtc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Ornithine into the cell in exchange for L-Leucine by b0,+AT transporter at the apical surfaces of the membranes of small intestine and renal cells.
type: Reaction

metaR EICOSTETCPT2
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
reversible: false
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_d0dd8d10_7e84_409b_a35b_57b755dbbbc8
boundary condition: true
constant: false
is encoded by: hsa:2571
has only substance units: false
initial amount: NaN
is: Q8IVA8
name: GAD1
is: SBO:0000252
initial concentration: NaN
type: Species

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR It
modifier: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
reactant: MODEL1310110013#
name: Iodide uniport

http://identifiers.org/biomodels.db/MODEL1310110013#_96146288_3dee_4ae0_8ba4_a0574ee373d9
has only substance units: false
name: DGUOK
initial concentration: NaN
type: Species
is encoded by: hsa:1716
is: Q16854
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR GALC
kinetic law: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2581.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.46 Confidence Level: 4 AUTHORS: PMID:7601472 NOTES:NJ
reversible: false
name: Galactocerebrosidase
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.46

metaM pep m
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:18021
is: HMDB00263
type: Species
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
name: Phosphoenolpyruvate
is: C00074
is: SBO:0000247
initial concentration: 1.0

metaR TREHe
type: Reaction
reversible: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.28
name: alpha,alpha-trehalase
fast: false
is: SBO:0000176
product: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
is described by: ECO:0000269

metaM dtdp m
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
constant: false
name: dTDP
has only substance units: false
is: CHEBI:58369
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00363
initial amount: NaN

metaM pail3p hs c
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:58088
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
is: SBO:0000247

metaM HC00591 m
is: CHEBI:16769
constant: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 2-oxoglutaramate
type: Species
boundary condition: false

metaR EICOSTETCPT1
modifier: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reversible: false
reactant: MODEL1310110013#
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110013#_ab79a5f0_3907_4235_9869_f8e4fe7b39fc
is: Q15392
is: SBO:0000252
constant: false
is encoded by: hsa:1718
initial amount: NaN
boundary condition: true
has only substance units: false
name: DHCR24
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_e2ff0e07_88f4_4aea_9ed3_33bd385e266d
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84569
is: Q6UWQ5
initial amount: NaN
boundary condition: true
name: LYZL1
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_72487f57_8a8e_49c5_af1a_178058c0bce0
type: Species
is: Q9NQR4
constant: false
boundary condition: true
is encoded by: hsa:56954
name: NIT2
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_94debecc_f654_4db6_be31_0b75c18ebf70
boundary condition: true
is: Q9UHW9
type: Species
is encoded by: hsa:9990
name: SLC12A6
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaR r2435
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
kinetic law: MODEL1310110013#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.8.3
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_3daed4d3_e6bf_453e_b7c4_e3f011cbd694
is encoded by: hsa:956
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: ENTPD3
is: O75355

metaR SRTNt6 2 r
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000185
product: MODEL1310110013#
reactant: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_9660d752_42d6_4906_a2b1_2b61e60263d3
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:224
initial concentration: NaN
is: P51648
constant: false
name: ALDH3A2

http://identifiers.org/biomodels.db/MODEL1310110013#_82861d76_d255_4113_8057_ac6940665712
initial amount: NaN
initial concentration: NaN
name: PANK4
is: SBO:0000252
type: Species
is encoded by: hsa:55229
has only substance units: false
boundary condition: true
constant: false
is: Q9NVE7

metaR HPACtr
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: hydroxyphenylacetate transport via diffusion
is: SBO:0000185
fast: false
reactant: MODEL1310110013#
type: Reaction
reversible: true
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

metaR 4HOXPACDOX NADP
is described by: ECO:0000304
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110013#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reversible: true
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_89822ed7_3a5f_491a_a313_0e895a43390f
is: B4DKS0
constant: false
is encoded by: hsa:6566
name: SLC16A1
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_ef166179_72de_49e2_a0c2_0e2f9b650429
initial amount: NaN
is: B4DYG5
is encoded by: hsa:5297
constant: false
type: Species
name: PI4KA
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM xu5p D c
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:57737
name: D-xylulose 5-phosphate(2-)
type: Species
is: HMDB00868
initial amount: NaN
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_88079bf3_f71b_4e40_bde9_a1c01ad14471
is: SBO:0000297
type: Species
has part: E9KL44
constant: false
has part: P55084
initial amount: NaN
is encoded by: hsa:3030
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3032
boundary condition: true
name: HADHA:HADHB

metaM retn e
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB01852
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate
constant: false

metaR PI34P5K
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is described by: ECO:0000000
modifier: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.68
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_bd7ebcef_0bc9_4560_b5d9_cb09a45ba297
is: Q96P26
name: NT5C1B
is: SBO:0000252
is encoded by: hsa:93034
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_0f02bba6_01f6_4962_8374_f75628095109
has only substance units: false
boundary condition: true
is: Q15392
constant: false
is encoded by: hsa:1718
initial concentration: NaN
is: SBO:0000252
name: DHCR24
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_b8eb83c4_00a3_436a_894d_5e73e1f1bdd5
type: Species
initial concentration: NaN
is encoded by: hsa:3612
name: IMPA1
is: SBO:0000252
boundary condition: true
is: B7Z6Q4
initial amount: NaN
constant: false
has only substance units: false

metaM 4abut c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
is: HMDB00112
name: 4-Aminobutanoate
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:3628

http://identifiers.org/biomodels.db/MODEL1310110013#_154793dc_ad6c_4421_9ce4_51d63f4a0849
is: Q02318
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1593
type: Species
name: CYP27A1
boundary condition: true
is: SBO:0000252

metaR r2360
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110013#
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_7eb2973c_b9e9_4de4_bc93_627393a5f596
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4540
has part: B7Z792
has part: P17568
is encoded by: hsa:4539
has part: O43674
is encoded by: hsa:4535
is encoded by: hsa:4705
is encoded by: hsa:4538
initial amount: NaN
has part: B1AM93
has part: Q9Y6M9
has part: Q85KV6
has part: Q549M5
has part: Q13454
is encoded by: hsa:4694
has part: O95169
type: Species
is encoded by: hsa:4709
has part: Q16795
is encoded by: hsa:4729
is encoded by: hsa:4714
constant: false
is encoded by: hsa:4712
has part: P28331
has part: O95299
is encoded by: hsa:4717
is encoded by: hsa:4702
is encoded by: hsa:4700
is encoded by: hsa:4720
has part: Q6IBB5
has part: P56181
has part: O75438
has part: P19404
boundary condition: true
has part: Q6FG42
is encoded by: hsa:126328
has part: O43181
is encoded by: hsa:4697
is encoded by: hsa:4698
is encoded by: hsa:4716
has part: F8VQS7
has part: Q16718
is encoded by: hsa:4704
is encoded by: hsa:4726
has part: O43677
is encoded by: hsa:4537
has part: O14561
is encoded by: hsa:4725
has part: Q6IBC4
is encoded by: hsa:4723
is encoded by: hsa:4708
is encoded by: hsa:4728
is encoded by: hsa:4713
is encoded by: hsa:4711
is encoded by: hsa:4731
is encoded by: hsa:4707
is encoded by: hsa:4710
has part: Q6IB80
has part: O00483
has part: O95167
has part: O00217
has part: C9JT23
has part: O43678
is encoded by: hsa:7991
has part: A8K761
is encoded by: hsa:51079
has part: Q7GXZ1
has part: Q7GXZ4
has only substance units: false
is: SBO:0000297
is encoded by: hsa:4536
has part: H7C5B8
is encoded by: hsa:4696
is encoded by: hsa:4715
has part: P03905
has part: Q6IBA0
has part: O95139
is encoded by: hsa:4695
has part: Q7GXY9

http://identifiers.org/biomodels.db/MODEL1310110013#_9a935a81_244f_42dc_abd3_1e0e411e2aec
is encoded by: hsa:U37519
is: SBO:0000252
initial concentration: NaN
name: _U37519_1_e
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM succoa x
is: HMDB01022
has only substance units: false
is: SBO:0000247
name: Succinyl-CoA
constant: false
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM pheacgln e
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB06344
boundary condition: false
type: Species
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial amount: NaN
is: CHEBI:58310
initial concentration: 1.0

metaM 3hmbcoa m
initial amount: NaN
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57312
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: HMDB01356

metaM accoa n
is: CHEBI:57288
type: Species
has only substance units: false
is: HMDB01206
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
initial concentration: 1.0
name: acetyl-CoA(4-)
is: SBO:0000247
boundary condition: false

metaM oaa c
type: Species
initial concentration: 1.0
constant: false
name: Oxaloacetate
is: HMDB00223
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:3338
is: C00036
notes: FORMULA: C4H2O5 CHARGE: -2

metaR 5MTHFt
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
product: MODEL1310110013#
modifier: MODEL1310110013#

metaR FATP3t
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
reactant: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000185
name: fatty acid electroneutral transport
reversible: true
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_ce143d35_60d4_4fa3_bd04_c44e3826c038
is encoded by: hsa:206358
has only substance units: false
boundary condition: true
name: SLC36A1
initial concentration: NaN
is: Q1LZ56
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

metaR RE3381E
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
product: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
type: Reaction
fast: false
name: RE3381

http://identifiers.org/biomodels.db/MODEL1310110013#_5fa87ab0_998a_4e59_9281_12beb4033d72
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3423
boundary condition: true
is: B4DGD7
name: IDS
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ed05f2d0_0516_4088_9717_d984713b42b5
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: DGKE
is encoded by: hsa:8526
is: A1L4Q0

http://identifiers.org/biomodels.db/MODEL1310110013#_9925bb28_e00d_4835_a6da_2e9ca21bfbae
is: Q9Y666
boundary condition: true
is: SBO:0000252
constant: false
name: SLC12A7
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10723
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_160c3b28_073e_49a3_bdeb_4288f41bd629
initial amount: NaN
boundary condition: true
name: MCCC1:MCCC2
has part: Q96RQ3
has only substance units: false
constant: false
type: Species
has part: Q9HCC0
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:56922
is encoded by: hsa:64087

http://identifiers.org/biomodels.db/MODEL1310110013#_d146fa2a_9915_4ab7_9784_147cc4740630
constant: false
is: SBO:0000252
name: MIA3
initial concentration: NaN
is encoded by: hsa:375056
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: Q5JRA6

metaM acgalfucgalacglcgalgluside hs g
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
constant: false
boundary condition: false
is: CHEBI:57847
has only substance units: false
is: HMDB00304
name: Type IA glycolipid

metaM accoa m
boundary condition: false
name: Acetyl-CoA
is: HMDB01206
constant: false
initial amount: NaN
is: CHEBI:57288
is: C00024
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
has only substance units: false
type: Species

metaR CYTK9n
modifier: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
reversible: true
product: MODEL1310110013#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dCTP),nuclear
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110013#_a5d276f5_d985_413e_b097_f0bc3c5c9925
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9517
type: Species
is encoded by: hsa:10558
boundary condition: true
has part: O15270
name: SPTLC1:SPTLC2
has only substance units: false
has part: O15269
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_539d8acf_c615_44df_9a65_e345d51e81a7
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: Q16795
boundary condition: true
name: NDUFA9
is: SBO:0000252
is encoded by: hsa:4704

http://identifiers.org/biomodels.db/MODEL1310110013#_bbb9e391_96f1_4974_be01_6d80639b6937
is encoded by: hsa:154091
initial concentration: NaN
name: SLC2A12
is: SBO:0000252
has only substance units: false
type: Species
is: Q8TD20
boundary condition: true
constant: false
initial amount: NaN

metaM dtdp n
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247
initial amount: NaN
is: CHEBI:58369
is: HMDB01274
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

http://identifiers.org/biomodels.db/MODEL1310110013#_ae1e66c7_a582_413c_a7e8_e565afb83455
type: Species
name: ACAA2
has only substance units: false
is: P42765
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10449
initial amount: NaN
boundary condition: true
constant: false

metaR DHCHOLESTANATEtm
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110013#_00d630a6_3c3e_4de8_8edd_f412e0b9f049
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: PDE1C
initial amount: NaN
is encoded by: hsa:5137
is: Q8NB10
constant: false

metaR FAOXC165C164x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaM CE2838 e
name: maltononaose
type: Species
is: C01936
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_774d08d0_9191_48f8_b445_1d5142587222
type: Species
boundary condition: true
constant: false
name: SLC24A4
has only substance units: false
is: SBO:0000252
is encoded by: hsa:123041
initial concentration: NaN
initial amount: NaN

metaR CHAT
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
type: Reaction
is described by: ECO:0000269
reversible: true
name: Choline O-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.6
modifier: MODEL1310110013#
is: SBO:0000176
fast: false
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_25bcadbd_df02_4934_a81a_f679b0be2a0d
is encoded by: hsa:4701
boundary condition: true
initial amount: NaN
type: Species
name: NDUFA7
is: SBO:0000252
is: Q6FG42
initial concentration: NaN
has only substance units: false
constant: false

metaM pheacgln c
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: SBO:0000247
is: HMDB06344
boundary condition: false
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
type: Species
initial amount: NaN
is: CHEBI:58310
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ad3a23dc_b1af_4b2a_86cc_a8fff82b3ba3
is: O95861
name: BPNT1
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:10380
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_ff4c7991_69cc_4790_82d9_f88e84269290
has only substance units: false
boundary condition: true
name: _BE966236_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:BE966236
initial amount: NaN
initial concentration: NaN
constant: false

metaR SERGLNexR
type: Reaction
reactant: MODEL1310110013#
name: L-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
modifier: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_339a6641_ee83_4566_a49e_fd33eb4517b2
name: _BE966236_1_m
constant: false
has only substance units: false
is encoded by: hsa:BE966236
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_33e7fe32_120b_4a39_957e_37d4c16fb672
is encoded by: hsa:1339
boundary condition: true
initial concentration: NaN
name: COX6A2
has only substance units: false
initial amount: NaN
is: Q02221
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_737eecc3_d346_463a_bed2_975a7d1fe3a0
is encoded by: hsa:522
is encoded by: hsa:518
is encoded by: hsa:515
is encoded by: hsa:10476
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has part: O75947
initial amount: NaN
boundary condition: true
type: Species
has part: P18859
constant: false
has part: P24539
initial concentration: NaN
is: SBO:0000297
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ee47014e_7f06_4d5d_87a6_a82ab078951b
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:131
type: Species
is: P40394
name: ADH7
has only substance units: false
constant: false

metaM pa hs c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
name: phosphatidate(2-)
boundary condition: false
is: CHEBI:57739

metaR SGALSIDEtl
is: SBO:0000185
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
name: sgalside hs intracellular transport
reversible: true

metaR MECOALm
reversible: true
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
is version of: http://identifiers.org/ec-code/6.2.1.5
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000212
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_92c9905b_7d0d_4c6f_833e_c02ac6c3f048
initial amount: NaN
is encoded by: hsa:3098
has only substance units: false
is: SBO:0000252
is: A8K7J7
type: Species
constant: false
initial concentration: NaN
name: HK1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_6ddfc986_db76_4c0a_b9bd_0d9d8e0e419b
initial concentration: NaN
has only substance units: false
is: P07451
is encoded by: hsa:761
type: Species
name: CA3
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_a2fb1b6c_bbd6_430c_9c0c_f30bc0f2ead3
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: P12074
initial concentration: NaN
type: Species
name: COX6A1
is encoded by: hsa:1337
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_4719877b_c015_4b94_8643_80f110422599
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5286
is: SBO:0000252
type: Species
boundary condition: true
is: O00443
name: PIK3C2A
initial amount: NaN

metaM tchola c
is: CHEBI:36257
boundary condition: false
name: taurocholic acid
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial amount: NaN
is: HMDB00036
has only substance units: false

metaM lcts e
type: Species
is: CHEBI:17716
constant: false
initial concentration: 1.0
name: Lactose
initial amount: NaN
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: C00243
is: HMDB00186
has only substance units: false
is: SBO:0000247

metaR N3Tg
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
type: Reaction
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.4.1.122
reversible: false
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
reactant: MODEL1310110013#

metaR FAOXC18480m
fast: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: Beta oxidation of fatty acid
modifier: MODEL1310110013#

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM sphs1p e
has only substance units: false
is: HMDB00277
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0
boundary condition: false
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119

http://identifiers.org/biomodels.db/MODEL1310110013#_d00ae151_f0fa_4404_bc4d_08a807ac1478
name: COX4I1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P13073
boundary condition: true
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:1327

metaR FAOXC150m
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
reactant: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
fast: false
reversible: false

metaM HC02204 e
initial amount: NaN
is: CHEBI:27624
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial concentration: 1.0

metaM ksii core2 deg3 l
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
name: keratan sulfate II (core 2-linked), degradation product 3
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:12936
is: HMDB00143

metaM ei11ecoa x
type: Species
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 11-eicosenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_cc4d21a0_b0b5_4dd3_8fdb_f92a6c11c6fd
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:5152
name: PDE9A
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_2f6b972b_86f4_4831_9fe3_3906c7a6cd93
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:222
boundary condition: true
is: P48448
initial concentration: NaN
has only substance units: false
type: Species
name: ALDH3B2
constant: false

metaR FACOAL1821
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
type: Reaction
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
is: SBO:0000176
name: fatty-acid--CoA ligase

metaR P4503A5
fast: false
modifier: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110013#
name: cytochrome P450 3A5
is described by: ECO:0000269
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1577.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15579107 NOTES:_8,9 epoxidation of aflatoxin assumed to take place on outer membrane NJ
is version of: http://identifiers.org/ec-code/1.14.14.1

metaR GALt1r
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
name: galactose transport (uniport)
is described by: ECO:0000269
fast: false
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110013#_f2d4a364_19d5_4821_aeeb_72ffc735d90f
initial amount: NaN
is encoded by: hsa:2348
has only substance units: false
type: Species
is: SBO:0000252
is: P15328
name: FOLR1
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_02630901_5318_47c2_b3bf_4943f80fbe75
is encoded by: hsa:3033
is: Q16836
initial amount: NaN
constant: false
boundary condition: true
name: HADH
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM lnlccoa c
initial concentration: 1.0
name: linoleic coenzyme A
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_4d7067f7_f377_4dab_8669_9783571c18b2
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
name: ATP5A1
boundary condition: true
is: A8K092
type: Species
initial concentration: NaN
is encoded by: hsa:498

http://identifiers.org/biomodels.db/MODEL1310110013#_14eb4352_7c2d_4edc_8d48_d0679e43c22f
name: SKIV2L2
type: Species
initial amount: NaN
is encoded by: hsa:23517
is: Q3MHC9
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM tchola e
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: taurocholic acid
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00036
notes: FORMULA: C26H45NO7S CHARGE: 0

metaR S23Tg
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4
is described by: ECO:0000269
kinetic law: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_3fe493fc_18a6_45a4_9d94_2dad018db8d2
name: GALNT9
is encoded by: hsa:50614
initial concentration: NaN
type: Species
is: Q9HCQ5
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaM C05957 r
name: Prostaglandin J2
type: Species
initial amount: NaN
is: HMDB02710
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
has only substance units: false
is: CHEBI:27485

http://identifiers.org/biomodels.db/MODEL1310110013#_4ce00c8c_a23d_4dff_afbe_1afd0a0b5e77
is: O95167
is: SBO:0000252
constant: false
is encoded by: hsa:4696
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NDUFA3
boundary condition: true

metaM 4abut e
is: C00334
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0
boundary condition: false
initial amount: NaN
name: 4-Aminobutanoate
has only substance units: false
is: HMDB00112
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:3628

http://identifiers.org/biomodels.db/MODEL1310110013#_e955c7f0_e604_4677_a3e8_39b4b4bacefe
initial amount: NaN
is encoded by: hsa:AI761708
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: _AI761708_1_m
has only substance units: false

metaM lcts g
initial amount: NaN
is: SBO:0000247
is: CHEBI:17716
is: HMDB00186
name: lactose
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
constant: false
boundary condition: false

metaR FACOAL1822
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110013#
type: Reaction
name: fatty-acid--CoA ligase
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000176

metaM sphs1p c
is: CHEBI:60119
type: Species
is: HMDB00277
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_5df27528_9eaa_4325_8818_05bc49838202
name: SLC26A6
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:65010
is: Q9Y3Y1
initial amount: NaN
is: SBO:0000252

metaM HC00591 c
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16769
initial concentration: 1.0
initial amount: NaN
name: 2-oxoglutaramate
type: Species
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false

metaM pe hs r
is: CHEBI:16038
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
initial amount: NaN
type: Species
name: phosphatidylethanolamine
initial concentration: 1.0

metaR LPS3e
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
name: lipase, extracellular
is: SBO:0000176
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.1.3
type: Reaction

metaR DNDPt29m
reversible: false
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110013#
is: SBO:0000185
name: dCDP transport via dADP antiport

http://identifiers.org/biomodels.db/MODEL1310110013#_a56249f6_d8f0_4e43_9ec1_7ddb3adde215
is encoded by: hsa:8560
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: O15121
name: DEGS1

metaM accoa x
is: SBO:0000247
name: Acetyl-CoA
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
is: HMDB01206
is: C00024
type: Species
constant: false
is: CHEBI:57288
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ef7e1250_dd29_4088_a24d_538a722e31d9
type: Species
name: _AI222095_1_m
is encoded by: hsa:AI222095
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaR G5SADrm
kinetic law: MODEL1310110013#
type: Reaction
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_75ebd214_73f7_419a_be13_8e958a6f1eae
is encoded by: hsa:65010
boundary condition: true
is: SBO:0000252
constant: false
is: Q548A7
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
name: SLC26A6

metaR C226CPT1
modifier: MODEL1310110013#
fast: false
name: carnitine C22:6 transferase
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is: SBO:0000176
reactant: MODEL1310110013#

metaR r0321
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.5.2
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
fast: false
product: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
type: Reaction

metaR CHOLESACATc
reversible: false
name: esterification of cholesterol to cholesterol ester within enterocytes
is: SBO:0000176
product: MODEL1310110013#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.3.1.26
type: Reaction
fast: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (8435.1) or (6646.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 143-144. charasuraisin, c. in short dissertation 19 (2008) NOTES:re-formation of cholesterol ester within enterocytes, then exit in chylomicrons into the lymph.
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_c2e0814a_a4d1_4461_b12e_810ce145d08f
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:6715
is: P18405
has only substance units: false
name: SRD5A1
boundary condition: true
initial concentration: NaN
constant: false

metaR SPODM
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110013#
name: superoxide dismutase
product: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR

metaR FACOAL180i
is: SBO:0000176
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
name: C180 fatty acid activation
modifier: MODEL1310110013#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_c217583c_976d_49a2_b716_36462b2e1d39
name: MECR
type: Species
is: Q9BV79
is encoded by: hsa:51102
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

metaM malttr e
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:27931
name: maltotriose
has only substance units: false
initial concentration: 1.0
is: C01835
is: SBO:0000247
is: HMDB01262
type: Species

metaM pa hs g
is: CHEBI:57739
initial concentration: 1.0
constant: false
name: phosphatidate(2-)
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
has only substance units: false

metaM pnto R e
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: SBO:0000247
name: (R)-Pantothenate
type: Species
has only substance units: false
is: HMDB00210
is: CHEBI:7916
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR C226CPT2
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
fast: false
name: C226 transport into the mitochondria
is: SBO:0000176
kinetic law: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110013#

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_c4f08b19_b4fc_4424_8f06_33e22e99a083
boundary condition: true
is: SBO:0000252
has only substance units: false
name: BTD
type: Species
is encoded by: hsa:686
is: P43251
initial amount: NaN
initial concentration: NaN
constant: false

metaR LEUKTRE4t
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110013#
name: leukotriene E4 transport

metaM dump c
is: HMDB01409
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00365
name: dUMP
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
is: CHEBI:246422

metaR GLU5Km
product: MODEL1310110013#
name: glutamate 5-kinase (m)
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
is described by: ECO:0000254
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.1.41
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m

metaM ksi l
initial amount: NaN
is: HMDB01354
type: Species
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I
is: C00445
is: CHEBI:57455
constant: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_36d4eb22_040b_4e9c_9eea_cc50408278f5
boundary condition: true
is: SBO:0000252
is encoded by: hsa:56922
is: Q96RQ3
name: MCCC1
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_1ea2426b_d970_432b_8e0e_8807b125735d
has only substance units: false
boundary condition: true
name: GALT
is encoded by: hsa:2592
initial amount: NaN
is: B2RAT6
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR SGALSIDEtg
is described by: ECO:0000000
is: SBO:0000185
name: sgalside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#

metaR GGH 10FTHF7GLUe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_6a50c16d_ff26_4990_b334_23c6bc8e15fe
type: Species
is encoded by: hsa:353
is: P07741
initial concentration: NaN
name: APRT
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaM retn c
is: SBO:0000247
type: Species
is: HMDB01852
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
name: all-trans-retinoate
is: CHEBI:35291

metaM mi145p c
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: SBO:0000247
is: CHEBI:203600
is: HMDB01498
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)

metaM CE2422 m
is: CHEBI:28387
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB11123
has only substance units: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
boundary condition: false
constant: false
initial amount: NaN

metaM dd3coa x
name: 3-dodecenoylcoa
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB04257

http://identifiers.org/biomodels.db/MODEL1310110013#_ae7a08e0_a92f_4668_89e8_c6c4d1984945
name: _AU149534_1_c
constant: false
has only substance units: false
is encoded by: hsa:AU149534
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaR ME1m
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: malic enzyme (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.38
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM pnto R c
name: (R)-Pantothenate
is: HMDB00210
is: CHEBI:7916
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_1ed9a0ff_63c9_4931_8a0b_410ba3a4fbaa
is: SBO:0000252
constant: false
has only substance units: false
is: B7Z2M9
boundary condition: true
type: Species
name: DGKZ
initial amount: NaN
is encoded by: hsa:8525
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_9173cbbc_1495_453e_a824_47beb25fb30d
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:1503
initial amount: NaN
initial concentration: NaN
constant: false
name: CTPS1
is: SBO:0000252
is: P17812

metaM mn l
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
has only substance units: false
constant: false
boundary condition: false
name: beta-1,4-mannose-N-acetylglucosamine
initial concentration: 1.0
is: HMDB06535
is: SBO:0000247
initial amount: NaN
type: Species

metaR 2AMADPTm
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
name: L-2-aminoadipate shuttle (cytosol/mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110013#_13c221da_1c8b_41fc_9425_459a992438a5
initial concentration: NaN
initial amount: NaN
name: ATP5J2
has only substance units: false
is: Q6IBB3
is: SBO:0000252
is encoded by: hsa:9551
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_85e65ea4_eb56_4e7c_ab23_6cb17e81323e
boundary condition: true
is: Q96JQ3
initial amount: NaN
name: CSAD
constant: false
initial concentration: NaN
is encoded by: hsa:51380
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_5e9145b2_56ab_4038_a495_964fbd539545
is encoded by: hsa:9615
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9Y2T3
initial amount: NaN
constant: false
type: Species
name: GDA
has only substance units: false

metaM 9 cis retfa e
boundary condition: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06559
is: SBO:0000247
constant: false
name: fatty acid 9-cis-retinol
has only substance units: false

metaM ksi deg27 l
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
constant: false
has only substance units: false
name: keratan sulfate I, degradation product 27

http://identifiers.org/biomodels.db/MODEL1310110013#_43600e3e_cc57_435b_a533_b954ec6ef91c
initial amount: NaN
is: P49327
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2194
name: FASN

http://identifiers.org/biomodels.db/MODEL1310110013#_5c0829b3_9f1d_410f_a49c_f22adee2ebaa
initial concentration: NaN
name: _AA502753_1_m
has only substance units: false
is encoded by: hsa:AA502753
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM HC02204 c
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:27624
constant: false
type: Species
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial concentration: 1.0
boundary condition: false

metaM hs deg17 l
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
initial concentration: 1.0
is: HMDB02704
name: heparan sulfate, degradation product 17
type: Species
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:21338
initial amount: NaN
is: SBO:0000247

metaM b2coa m
initial amount: NaN
name: crotonoyl-CoA(4-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
is: CHEBI:57332
has only substance units: false
constant: false
is: HMDB02009
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_347391ff_c983_402d_9cf7_55fb089fa7e8
is encoded by: hsa:2954
is: O43708
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: GSTZ1
type: Species

metaR DOPAtu
type: Reaction
fast: false
reactant: MODEL1310110013#
reversible: true
is: SBO:0000185
product: MODEL1310110013#
modifier: MODEL1310110013#
name: Dopamine uniport
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is described by: ECO:0000269

metaR B3GNT39g
is described by: ECO:0000000
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
product: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_9aea5344_4dc2_4900_ab99_37c66e9d49de
constant: false
initial amount: NaN
name: RPE
type: Species
has only substance units: false
is encoded by: hsa:6120
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q53TV9

http://identifiers.org/biomodels.db/MODEL1310110013#_9be9d8b4_3623_4758_8075_2bbba59a2609
has only substance units: false
name: ACSS2
is encoded by: hsa:55902
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: Q96FY7

metaM HC00342 m
initial amount: NaN
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: cis-aconitate(3-)
is: CHEBI:16383

http://identifiers.org/biomodels.db/MODEL1310110013#_493d463c_4cc5_4e5c_8d13_091c0e6bd719
is: SBO:0000252
constant: false
initial amount: NaN
name: SULT1A1
boundary condition: true
is encoded by: hsa:6817
has only substance units: false
initial concentration: NaN
type: Species

metaR NRPPHRtu
reversible: true
type: Reaction
reactant: MODEL1310110013#
name: Norepinephrine uniport
is described by: ECO:0000269
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaR EX sfcys LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sulfocysteine
type: Reaction

metaR TKT1
product: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.2.1.1
is: SBO:0000176
reversible: true
name: transketolase
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
type: Reaction

metaR r0642
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
kinetic law: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000

metaR GLYCt
reactant: MODEL1310110013#
type: Reaction
name: glycerol transport via channel
reversible: true
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR r0365
type: Reaction
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reactant: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_e357e3aa_7e8d_409a_82c6_1511f2cccc07
is: SBO:0000297
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
has part: P56134
is encoded by: hsa:522
is encoded by: hsa:9551
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_da523459_ce82_4dcc_b008_b02eac5accd6
is: SBO:0000252
initial amount: NaN
type: Species
name: DGUOK
boundary condition: true
has only substance units: false
is encoded by: hsa:1716
initial concentration: NaN
constant: false

metaM coa n
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
is: HMDB01423
name: coenzyme A(4-)
is: CHEBI:57287
boundary condition: false
initial amount: NaN
type: Species

metaM bildglcur c
constant: false
initial concentration: 1.0
type: Species
is: HMDB03325
name: bis(beta-glucosyluronate)bilirubin
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:58471
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaR P45027A1m
product: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Cytochrome P450 27
reversible: false
reactant: MODEL1310110013#
fast: false

metaR DTDPtn
reactant: MODEL1310110013#
is described by: ECO:0000000
reversible: true
name: dTDP nuclear transport
type: Reaction
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000185

metaR r2003
fast: false
is: SBO:0000185
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
modifier: MODEL1310110013#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR r2338
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
reversible: true
is: SBO:0000185
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_12d4cca3_0081_436d_a8d7_6997b0988b5a
is: SBO:0000297
is encoded by: hsa:23428
type: Species
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
has part: Q9UHI5
name: SLC7A8:SLC3A2

metaR NADtx
kinetic law: MODEL1310110013#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110013#
type: Reaction
is: SBO:0000185
reversible: true
name: transport of NAD into peroxisome
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_510459c6_3765_4393_b6e5_e7c4f6b83da3
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
has part: Q06055
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
boundary condition: true
is encoded by: hsa:517
is: SBO:0000297

metaM g3p c
is: SBO:0000247
initial amount: NaN
is: HMDB01112
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3930
name: Glyceraldehyde 3-phosphate
has only substance units: false
is: CHEBI:58027
initial concentration: 1.0
is: C00661
type: Species
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116

metaR PItn
kinetic law: MODEL1310110013#
name: phosphate transport, nuclear
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
product: MODEL1310110013#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_1fa5cba5_6ca6_44e8_9a23_3eb8970c775e
type: Species
name: CANT1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:124583
has only substance units: false
initial amount: NaN
is: Q8WVQ1

http://identifiers.org/biomodels.db/MODEL1310110013#_edf6fc20_8eb7_4918_94e2_74af3a398709
name: PLCL1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5334
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: Q15111
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_5527fa8a_5e6e_4489_9788_0862f2c3896c
boundary condition: true
is encoded by: hsa:5152
initial concentration: NaN
is: SBO:0000252
name: PDE9A
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR BACCLm
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 2 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
product: MODEL1310110013#
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.3.4.10
fast: false
type: Reaction
name: biotin-[acetyl-CoA-carboxylase] ligase, mitochondrial
reversible: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000254

metaM hs deg9 l
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
is: HMDB00187
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
is: SBO:0000247
is: CHEBI:17115
name: heparan sulfate, degradation product 9

http://identifiers.org/biomodels.db/MODEL1310110013#_5778409c_2e52_4fb5_b67e_e04cf3e89413
name: _AI697028_1_e
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI697028
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_adbd9569_bdd2_4a42_ad0b_c246837866fd
is: SBO:0000252
is: P23919
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: DTYMK
constant: false
boundary condition: true
type: Species
is encoded by: hsa:1841

metaR FACOAL161
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
name: fatty-acid--CoA ligase (hexadecenoate)
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110013#
type: Reaction

metaR RE3050R
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
name: RE3050
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_6062e85e_d022_4597_85f2_b36b0af25ab1
is encoded by: hsa:2986
is: SBO:0000252
has only substance units: false
boundary condition: true
name: GUCY2F
initial amount: NaN
constant: false
initial concentration: NaN
is: P51841
type: Species

metaR DNDPt44m
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
name: dTTP transport via ATP antiport
fast: false
type: Reaction
is described by: ECO:0000269
product: MODEL1310110013#

metaM onpthl e
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: naphthalene epoxide
is: HMDB06215
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C10H8O CHARGE: 0 INCHI: InChI=1/C10H8O/c1-2-4-8-7(3-1)5-6-9-10(8)11-9/h1-6,9-10H

metaR TKT2
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.2.1.1
fast: false
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is: SBO:0000176
modifier: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
name: transketolase
product: MODEL1310110013#
is described by: ECO:0000000

metaR r0641
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.2.4
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
modifier: MODEL1310110013#
type: Reaction
reversible: true
fast: false
is: SBO:0000176
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

metaM bilirub r
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57977
has only substance units: false
is: HMDB00054
type: Species
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
name: bilirubin(2-)
initial concentration: 1.0

metaM adrncoa x
type: Species
is: http://identifiers.org/pubchem.compound/47205480
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
name: adrenyl coenzyme A
initial amount: NaN
constant: false

metaM 12ppd S c
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:29002
type: Species
initial concentration: 1.0
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
name: (S)-propane-1,2-diol
is: HMDB06213

http://identifiers.org/biomodels.db/MODEL1310110013#_9c3e69d9_12da_4f41_8ff4_ac152e04f415
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: Q14442
has only substance units: false
is: SBO:0000252
name: PIGH
initial amount: NaN
is encoded by: hsa:5283

metaM oxa m
constant: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: oxalate(2-)
is: HMDB02329
initial concentration: 1.0
is: CHEBI:30623
type: Species

metaR CYSGLTH
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false
name: Glutathione:cystine oxidoreductase
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
reversible: true

metaM dump m
initial amount: NaN
is: SBO:0000247
is: HMDB01409
type: Species
is: CHEBI:246422
has only substance units: false
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP(2-)
initial concentration: 1.0
constant: false

metaM nrvnc e
is: HMDB02368
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
boundary condition: false
is: SBO:0000247
name: nervonate
type: Species
constant: false
is: CHEBI:32392

http://identifiers.org/biomodels.db/MODEL1310110013#_fb9d6dc3_d879_46b2_a68a_131bfa4b22f2
type: Species
has only substance units: false
name: ALAS1
initial concentration: NaN
is: Q5JAM2
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:211

http://identifiers.org/biomodels.db/MODEL1310110013#_7c6cc890_5bd4_4244_b5b5_7162c360fa0b
is encoded by: hsa:410
name: ARSA
is: P15289
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_cf524220_f131_4c97_9a07_c3744ab38ba1
name: _AI924226_1_m
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI924226
initial concentration: NaN
type: Species

metaR r2333
kinetic law: MODEL1310110013#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110013#

metaM btn m
is: CHEBI:57586
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
name: biotinate
is: HMDB00030
initial concentration: 1.0
constant: false

metaR PYDAMK
product: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
fast: false
name: pyridoxamine kinase
type: Reaction
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.35
kinetic law: MODEL1310110013#
is described by: ECO:0000269

metaM arach c
initial amount: NaN
name: arachidate
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB02212
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
is: CHEBI:32360
type: Species
has only substance units: false

metaM hs deg2 l
is: SBO:0000247
initial amount: NaN
name: heparan sulfate, degradation product 2
is: HMDB06210
type: Species
has only substance units: false
constant: false
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7d3ae478_b3a0_40c3_9bc4_a8c48b3d3994
boundary condition: true
constant: false
is encoded by: hsa:1811
type: Species
name: SLC26A3
initial concentration: NaN
is: P40879
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_54adff3e_87e6_4593_a687_c2cbb28a573f
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:9153
name: SLC28A2
is: SBO:0000252
constant: false
boundary condition: true
is: O43868
initial concentration: NaN

metaR r0908
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110013#
reversible: true
fast: false
reactant: MODEL1310110013#

metaR ITCOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000212
fast: false
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is: SBO:0000176

metaM nrvnc c
name: nervonate
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: SBO:0000247
is: HMDB02368
is: CHEBI:32392

http://identifiers.org/biomodels.db/MODEL1310110013#_9e0c6e23_68c2_4736_8b56_04f359fc603b
initial amount: NaN
initial concentration: NaN
name: RPIA
has only substance units: false
is: SBO:0000252
is encoded by: hsa:22934
constant: false
is: P49247
boundary condition: true
type: Species

metaR r2334
reversible: true
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_fcbea957_0724_4e5d_bd6b_35b4b668d371
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: AK2
is encoded by: hsa:204
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c5e8efd2_f133_42c9_8a61_6f367b5ab7ed
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: B3GALT5
type: Species
has only substance units: false
is encoded by: hsa:10317

metaR TCHOLAtx
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
reactant: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
type: Reaction
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_137cd3ef_8890_4783_9566_53fd09bffc88
name: PIK3R5
initial amount: NaN
is: Q8WYR1
type: Species
boundary condition: true
is encoded by: hsa:23533
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR PTDCAt
kinetic law: MODEL1310110013#
is: SBO:0000185
fast: false
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

metaR ADAe
fast: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.5.4.4
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
reversible: false
modifier: MODEL1310110013#
name: Adenosine deaminase, extracellular
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176

metaR r0909
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reactant: MODEL1310110013#
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_07783484_729d_4349_bcb5_09cd760b676f
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3988
name: LIPA
is: P38571
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_d5510a4c_9f85_4b84_a307_efb62f05c411
has only substance units: false
is encoded by: hsa:AI971036
name: _AI971036_1_x
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_82702fa1_425d_4b15_a75e_c4bb9a321a8f
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:80704
name: SLC19A3
type: Species
is: Q9BZV2

http://identifiers.org/biomodels.db/MODEL1310110013#_117849e6_bf7a_4f66_a89f_fe4991681795
has only substance units: false
boundary condition: true
is: P35754
type: Species
initial concentration: NaN
is encoded by: hsa:2745
initial amount: NaN
constant: false
name: GLRX
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_c2820daa_2f80_4c3d_8480_c46a8e84fdea
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: ALDH3B1
initial concentration: NaN
is: P43353
has only substance units: false
is encoded by: hsa:221
initial amount: NaN

metaR r1885
reactant: MODEL1310110013#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110013#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110013#
type: Reaction

metaR PItg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
name: phosphate transport, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: false

metaM eicostetcoa c
type: Species
boundary condition: false
is: C16164
constant: false
initial concentration: 1.0
name: eicosatetranoyl coenzyme A
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
is: SBO:0000247

metaR EX onpthl LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: naphthalene epoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_a44ca067_6923_4e62_9d2a_7ffb1bc9970c
initial concentration: NaN
is encoded by: hsa:217
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ALDH2
is: P05091

metaM arach e
constant: false
is: HMDB02212
is: SBO:0000247
initial concentration: 1.0
name: arachidate
boundary condition: false
is: CHEBI:32360
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
type: Species
initial amount: NaN
has only substance units: false

metaR ALADGLYexR
name: D-alanine/glycine reversible exchange
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000304

metaM bildglcur e
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
initial amount: NaN
is: HMDB03325
initial concentration: 1.0
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_c7b9955a_d77a_40a0_9690_2e9291a61c97
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:5294
initial concentration: NaN
name: PIK3CG
type: Species
initial amount: NaN
is: P48736

metaR SIAT9g
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.4.99.9
modifier: MODEL1310110013#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
reactant: MODEL1310110013#

metaR LALDO2x
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
is described by: ECO:0000269
product: MODEL1310110013#
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_fba4bc6d_5617_4514_94dc_3e892257fae6
is: SBO:0000252
is encoded by: hsa:1349
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: COX7B
boundary condition: true
is: P24311
type: Species

metaR 4MPTNLte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
reactant: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: true
type: Reaction
name: 4-methylpentanal transport
fast: false
product: MODEL1310110013#
is described by: ECO:0000000

metaM btn n
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: CHEBI:57586
boundary condition: false
name: biotinate
is: HMDB00030
constant: false

metaM coa m
is: C00010
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
type: Species
is: CHEBI:57287
is: HMDB01423

metaM CE5788 e
is: HMDB02710
is: CHEBI:27485
type: Species
is: SBO:0000247
name: kinetensin 1-7
constant: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR OAGT3te
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110013#
reversible: true
name: oagt3 hs transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

metaM succ x
is: SBO:0000247
is: C00042
initial concentration: 1.0
is: HMDB00254
initial amount: NaN
is: CHEBI:30031
boundary condition: false
name: Succinate
has only substance units: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
type: Species

metaR CITRtm
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110013#
product: MODEL1310110013#
reversible: true
name: citrulline mitochondrial transport via proton antiport
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM atp c
is: CHEBI:30616
is: SBO:0000247
has only substance units: false
is: C00002
is: HMDB00538
name: ATP(4-)
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

metaR THCHOLSTOICtm
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
reversible: true

metaM malthx e
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: Maltohexaose
type: Species
is: C01936
initial concentration: 1.0
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
is: http://identifiers.org/pubchem.compound/5041

metaM retn r
constant: false
is: HMDB01852
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
type: Species
is: SBO:0000247
has only substance units: false
name: all-trans-retinoate
boundary condition: false
initial concentration: 1.0
is: CHEBI:35291

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR r2330
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
kinetic law: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110013#_e434a3a3_ad31_46fd_9d9e_15f26970a33a
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: GUSB
type: Species
is encoded by: hsa:2990
initial concentration: NaN
is: P08236

http://identifiers.org/biomodels.db/MODEL1310110013#_2e30f2e0_d333_47ce_a717_05fd09088130
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:226
name: ALDOA
is: P04075
type: Species
constant: false
is: SBO:0000252

metaR r0796
kinetic law: MODEL1310110013#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
modifier: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
reactant: MODEL1310110013#

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

metaR GALASE11ly
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110013#
fast: false
type: Reaction
product: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23

http://identifiers.org/biomodels.db/MODEL1310110013#_c9e57f72_a4a2_4357_ace9_3ae16487b6aa
name: HAO2
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:51179
type: Species
is: SBO:0000252
has only substance units: false

metaM coa x
boundary condition: false
is: C00010
type: Species
has only substance units: false
name: Coenzyme A
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial concentration: 1.0
is: HMDB01423
constant: false
is: CHEBI:57287

metaR FRDPtcr
kinetic law: MODEL1310110013#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
reactant: MODEL1310110013#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
product: MODEL1310110013#
is: SBO:0000185
reversible: true
fast: false
type: Reaction

metaR r2439
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
reactant: MODEL1310110013#
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
product: MODEL1310110013#
type: Reaction

metaM sphs1p r
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
initial amount: NaN
is: HMDB00277
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:60119
has only substance units: false

metaR r2331
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR TRDR
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is version of: http://identifiers.org/ec-code/1.8.1.9
kinetic law: MODEL1310110013#
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110013#
is: SBO:0000176
reversible: false
product: MODEL1310110013#
name: thioredoxin reductase (NADPH)

http://identifiers.org/biomodels.db/MODEL1310110013#_989e30e1_72a1_4ade_b71b_0c8a3da65ae8
boundary condition: true
is encoded by: hsa:10005
has only substance units: false
name: ACOT8
initial concentration: NaN
constant: false
initial amount: NaN
is: O14734
type: Species
is: SBO:0000252

metaM 2mp2coa m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 2-Methylprop-2-enoyl-CoA
is: HMDB01011
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: CHEBI:27754
boundary condition: false
has only substance units: false
constant: false

metaR RE2677E
product: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110013#
name: RE2677

metaR EAFLATOXINte
product: MODEL1310110013#
name: xenobiotic transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR UAG2EMAi
fast: false
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.14
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:
modifier: MODEL1310110013#
type: Reaction

metaM atp e
has only substance units: false
is: HMDB00538
is: C00002
is: CHEBI:57299
constant: false
boundary condition: false
name: ATP(4-)
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM pail4p hs n
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
is: CHEBI:58178
initial concentration: 1.0

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR HSPASEly
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
name: heparan sulfate proteoglycan protease, lysosome (endosome)
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD

http://identifiers.org/biomodels.db/MODEL1310110013#_fd1ed71e_cd20_4885_bf13_96da48f3ef13
has only substance units: false
name: _AI601100_1_m
is: SBO:0000252
constant: false
is encoded by: hsa:AI601100
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR PTDCACRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110013#
product: MODEL1310110013#
name: pentadecanoate transport into the mitochondria
reversible: false
kinetic law: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000185
fast: false

metaR r2332
fast: false
kinetic law: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110013#
type: Reaction
reversible: true
product: MODEL1310110013#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_1ccdbf2a_ec72_4714_8c36_2d6e1814e05f
is: SBO:0000252
has only substance units: false
is: F8VQS7
name: NDUFA12
type: Species
constant: false
boundary condition: true
is encoded by: hsa:55967
initial concentration: NaN
initial amount: NaN

metaR r0360
reversible: false
fast: false
modifier: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_b0f093e5_4522_4058_8230_6ff4c1b4fbde
initial concentration: NaN
initial amount: NaN
constant: false
is: E7EUT4
name: GAPDH
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:2597
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_c50c85a8_bde9_4e1c_988b_4c6508e39b17
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: O95263
name: PDE8B
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8622

metaR MAN6PI
is version of: http://identifiers.org/ec-code/5.3.1.8
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#
name: mannose-6-phosphate isomerase
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
is described by: ECO:0000304

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR PI5P3K
is version of: http://identifiers.org/ec-code/2.7.11.1
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.137
name: phosphatidylinositol-5-phosphate 3-kinase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_4a579e9f_936a_4de3_80ff_5c6f8b0e8eab
boundary condition: true
is encoded by: hsa:2182
is: SBO:0000252
name: ACSL4
type: Species
has only substance units: false
initial amount: NaN
is: O60488
constant: false
initial concentration: NaN

metaM ksii core4 deg4 l
initial amount: NaN
is: CHEBI:57455
notes: FORMULA: C66H108N6O48SX CHARGE: -1
name: keratan sulfate II (core 4-linked), degradation product 4
type: Species
is: HMDB01354
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7bbce9cf_909f_402a_a715_b9775f30e181
is: P06576
initial concentration: NaN
is encoded by: hsa:506
type: Species
name: ATP5B
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaR RE3242R
modifier: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000176
name: RE3242
reversible: true

metaM coa r
initial amount: NaN
is: CHEBI:57287
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
type: Species
is: HMDB01423
constant: false
initial concentration: 1.0
is: C00010
has only substance units: false
is: SBO:0000247

metaR ACS
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (65985.1) or (55902.2) or (55902.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 6.2.1.1 Confidence Level: 4 AUTHORS: PMID:10843999,PMID:12623130 NOTES:
name: acetyl-CoA synthetase
is version of: http://identifiers.org/ec-code/6.2.1.16
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.2.1.1
is: SBO:0000176
product: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110013#

metaM onpthl c
type: Species
is: SBO:0000247
is: HMDB06215
name: naphthalene epoxide
notes: FORMULA: C10H8O CHARGE: 0 INCHI: InChI=1/C10H8O/c1-2-4-8-7(3-1)5-6-9-10(8)11-9/h1-6,9-10H
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_92e3face_279d_42f7_829b_77c2a11684ca
initial concentration: NaN
name: PLCG1
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is: P19174
has only substance units: false
is encoded by: hsa:5335

metaR 3AIBTm
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110013#
name: L-3-aminoisobutyrate transaminase, mitochondrial
reversible: true
kinetic law: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110013#
is described by: ECO:0000304
reactant: MODEL1310110013#

metaM 7thf e
is: SBO:0000247
boundary condition: false
name: heptaglutamyl folate (THF)
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB06559
constant: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
has only substance units: false

metaM pydxn e
constant: false
is: C00314
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
type: Species
is: HMDB00239
is: CHEBI:16709
name: Pyridoxine
boundary condition: false
initial concentration: 1.0

metaR RE1845C
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
name: RE1845
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
is: SBO:0000176
reversible: true
reactant: MODEL1310110013#
fast: false

metaR RE2677G
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:
reactant: MODEL1310110013#
name: RE2677

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR SFGTH
fast: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.2.12
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
modifier: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
name: S-Formylglutathione hydralase
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110013#
type: Reaction

metaM oxa e
is: SBO:0000247
type: Species
name: oxalate(2-)
constant: false
is: CHEBI:30623
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_082c4352_2a4e_41a6_891f_877b7e44140a
initial concentration: NaN
is: P50053
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
name: KHK
is encoded by: hsa:3795
constant: false
boundary condition: true

metaR r0647
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
kinetic law: MODEL1310110013#
name: Spontaneous reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_bb6a481c_024a_4085_b1cf_fb3d1ae16069
initial concentration: NaN
has only substance units: false
name: AGPAT3
is: Q9NRZ7
constant: false
is encoded by: hsa:56894
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

metaM gsn e
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial amount: NaN
boundary condition: false
is: CHEBI:16750
is: HMDB00133
name: Guanosine
constant: false
is: SBO:0000247
is: C00387
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_91c83a6d_368b_482c_b7ec_48e27eb2fa0f
is encoded by: hsa:84002
initial concentration: NaN
boundary condition: true
is: Q9BYG0
is: SBO:0000252
has only substance units: false
constant: false
name: B3GNT5
initial amount: NaN
type: Species

metaR VALTA
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
type: Reaction
name: valine transaminase
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
modifier: MODEL1310110013#

metaR GGH 5THFe
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110013#
name: Gamma-glutamyl hydrolase (5THF), extracellular
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_01705d3c_66d7_45dc_801d_f447143b7e52
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: PAFAH1B1
type: Species
boundary condition: true
constant: false
is: P43034
is encoded by: hsa:5048
initial amount: NaN

metaR EX etoh LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ethanol exchange
type: Reaction

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR r2008
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
type: Reaction
product: MODEL1310110013#

metaR HAS2
is: SBO:0000185
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.212
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
name: hyaluronan synthase

metaM pydxn c
constant: false
is: C00314
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
type: Species
initial amount: NaN
name: Pyridoxine
boundary condition: false
is: HMDB00239
is: CHEBI:16709
initial concentration: 1.0

metaM frdp c
initial concentration: 1.0
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: C00448
name: Farnesyl diphosphate
is: CHEBI:175763
constant: false
boundary condition: false

metaM ptrc e
initial concentration: 1.0
is: HMDB01414
type: Species
is: CHEBI:326268
initial amount: NaN
name: Putrescine
boundary condition: false
has only substance units: false
is: SBO:0000247
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
constant: false

metaR GALASE10ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: beta-galactosidase, lysosomal
modifier: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR r0644
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110013#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1

http://identifiers.org/biomodels.db/MODEL1310110013#_67edca36_fcd0_4f15_9a59_6d42da937009
type: Species
constant: false
is: SBO:0000252
name: _HG2846_HT2983_1_c
boundary condition: true
has only substance units: false
is encoded by: hsa:HG2846-HT2983
initial amount: NaN
initial concentration: NaN

metaR r0797
name: glycine N-choloyltransferase EC:2.3.1.65
reactant: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_7bcb418f_553e_4d08_b7de_894be9f05598
is: Q96C36
initial amount: NaN
constant: false
type: Species
name: PYCR2
is: SBO:0000252
is encoded by: hsa:29920
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM oxa c
name: oxalate(2-)
type: Species
is: SBO:0000247
is: CHEBI:30623
constant: false
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
boundary condition: false
initial concentration: 1.0
is: HMDB02329
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_1e23ba3f_557f_47b6_b254_050683f6a77a
has only substance units: false
is: Q9H5J4
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:79071
name: ELOVL6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_a446ae92_a2cb_4004_9b52_bced8054d070
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:151531
is: O95045
initial amount: NaN
name: UPP2
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_1cf316f9_edbf_4c67_816c_9ee887889ab6
constant: false
has only substance units: false
name: _D87002_1_e
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:D87002
initial amount: NaN

metaR 4HDEBRISOQUINEte
is: SBO:0000185
name: xenobiotic transport
reversible: true
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ

metaR S6TASE1ly
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
modifier: MODEL1310110013#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_25aa161d_a9fa_48dd_90e8_ea746714c821
constant: false
is: B3KQ63
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3242
name: HPD

metaR FAOXC18280m
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
name: Beta oxidation of fatty acid
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110013#
is: SBO:0000176
type: Reaction

metaR 4MPTNLtm
type: Reaction
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
reversible: true
name: 4-methylpentanal transport (mitochondria)
is: SBO:0000185

metaR FAOXC102C103x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR FAS80COA L
is described by: ECO:0000269
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
product: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction

metaR H3ETer
modifier: MODEL1310110013#
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
is described by: ECO:0000304
product: MODEL1310110013#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM gsn c
constant: false
is: SBO:0000247
type: Species
name: Guanosine
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C00387
has only substance units: false
is: CHEBI:16750
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: HMDB00133

http://identifiers.org/biomodels.db/MODEL1310110013#_5e5e9f74_662e_40d6_8316_3f8c481119db
is: P34896
is encoded by: hsa:6470
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
name: SHMT1

metaR OAGT3tg
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
kinetic law: MODEL1310110013#
fast: false
name: oagt3 hs intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110013#_251d2f4f_c393_44d9_8b62_b3ea7bbd0aac
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is: F5GWS5
name: ADCY10
is encoded by: hsa:55811
boundary condition: true
constant: false
is: SBO:0000252

metaR PMANM
is: SBO:0000176
fast: false
modifier: MODEL1310110013#
name: phosphomannomutase
kinetic law: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/5.4.2.2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.4.2.8
product: MODEL1310110013#
reactant: MODEL1310110013#

metaM bilirub c
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false
is: CHEBI:57977
type: Species
is: HMDB00054
is: SBO:0000247
initial concentration: 1.0
name: bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110013#_041659c1_01d5_4dee_91af_fa18c0243030
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: A0PJJ9
constant: false
boundary condition: true
name: GGT7
is encoded by: hsa:2686
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_a45ebcc7_8440_4b8f_abed_bb7dd51ef8e5
has only substance units: false
is: Q9UNU6
type: Species
is encoded by: hsa:1582
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
name: CYP8B1

metaM lnlnca c
boundary condition: false
name: alpha-linolenate
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388
is: CHEBI:32387
constant: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_e695708e_d3de_43c3_82ef_e7d416a0e015
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P19367
constant: false
name: HK1
is encoded by: hsa:3098
initial amount: NaN
boundary condition: true

metaM HC02180 e
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:28728
initial amount: NaN
name: thromboxane-b2
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963

metaR r2443
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110013#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_bfe7233b_df1c_409c_8a5e_7e30d8dee6b0
name: SLC12A5
is: Q9H2X9
type: Species
constant: false
boundary condition: true
is encoded by: hsa:57468
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM 5HPET c
constant: false
is: CHEBI:57450
initial amount: NaN
is: HMDB01193
name: 5(S)-HPETE(1-)
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR FRUt4
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is described by: ECO:0000269
fast: false
name: D-fructose transport via sodium cotransport
type: Reaction
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_544d9869_b8f8_480f_bdf3_cafdab4c189e
constant: false
name: UCKL1
boundary condition: true
is: Q53HM1
is encoded by: hsa:54963
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

metaR NRPPHRSFt
name: norepinephrine sulfate transport (diffusion)
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#

metaR DTTPtn
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: dTTP diffusion in nucleus
is: SBO:0000185
reversible: true

metaM fald c
is: CHEBI:16842
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01426
name: formaldehyde
type: Species
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067

http://identifiers.org/biomodels.db/MODEL1310110013#_75b40ed0_ef9c_4e1d_8509_135cf49316b6
name: SORD
boundary condition: true
is encoded by: hsa:6652
constant: false
type: Species
is: Q00796
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR 7DHCHSTEROLtr
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: cholesterol precursor intracellular transport
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_c7ed51c5_b570_4a3d_9e04_a5667007d867
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P49748
is encoded by: hsa:37
name: ACADVL
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_874d2d96_613a_4156_87ff_a30c8f83dfb7
has only substance units: false
is encoded by: hsa:55163
constant: false
is: Q9NVS9
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: PNPO
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_60e7ec42_6c30_4717_b474_68e3e368f984
constant: false
type: Species
is: A6NN98
name: MTMR2
is: SBO:0000252
is encoded by: hsa:8898
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR P4502D6
is version of: http://identifiers.org/ec-code/1.14.14.1
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (1565.1) SUBSYSTEM: Cytochrome metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15579107 NOTES:debrisoquine 4-hydroxylation assumed to take place on outer membrane NJ
name: cytochrome P450 2D6
reversible: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaM l2n2m2mn l
is: SBO:0000247
constant: false
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
initial amount: NaN
is: HMDB00143
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:12936
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_0f1a9b03_13ed_47a3_9e1a_681c2ebf707c
is: SBO:0000252
constant: false
is: P12235
initial amount: NaN
name: SLC25A4
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:291
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_91a7b8d1_04b1_44a8_84a8_c77e57714799
is encoded by: hsa:3418
type: Species
name: IDH2
is: P48735
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM so4 e
name: sulfate
constant: false
has only substance units: false
is: HMDB01448
initial amount: NaN
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
is: CHEBI:16189
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_871e6fc9_1a44_44ff_b872_8a26ef9a724c
is: SBO:0000252
initial amount: NaN
name: _AI697028_1_m
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AI697028
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_9e6f233b_c64b_41e7_a67d_f9dd2de3e960
type: Species
name: _AU149534_1_m
initial concentration: NaN
is encoded by: hsa:AU149534
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

metaM mal L e
name: (S)-malate(2-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB00156
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
boundary condition: false
type: Species
constant: false
is: CHEBI:15589
initial amount: NaN

metaM HC02180 c
constant: false
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: thromboxane-b2
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN

metaM bildglcur r
initial amount: NaN
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
type: Species
is: SBO:0000247
is: HMDB03325
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ce932361_ff7f_4b94_a078_466a2477fb50
is encoded by: hsa:100287639
name: _100287639_1_c
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_e93ddceb_fe06_410f_9e92_c44ad51f2e0d
is: P30038
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:8659
name: ALDH4A1
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM succ m
has only substance units: false
name: Succinate
is: C00042
is: CHEBI:30031
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial amount: NaN
is: HMDB00254

http://identifiers.org/biomodels.db/MODEL1310110013#_c130e0f8_9855_486f_bb93_ebbc602a73bf
initial amount: NaN
is encoded by: hsa:10396
type: Species
constant: false
is: Q9Y2Q0
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ATP8A1
is: SBO:0000252

metaM atp m
has only substance units: false
is: SBO:0000247
is: CHEBI:57299
constant: false
is: HMDB00538
is: C00002
type: Species
initial amount: NaN
name: ATP(4-)
initial concentration: 1.0
boundary condition: false

metaR ACNAMlt
modifier: MODEL1310110013#
name: N-acetylneuraminate transport into lysososme
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110013#

metaM atp n
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
has only substance units: false
is: CHEBI:57299
type: Species
is: HMDB00538
name: ATP(3-)
initial amount: NaN

metaR r0202
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
product: MODEL1310110013#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110013#
is: SBO:0000176

metaR HPDCAt
name: fatty acid transport via diffusion
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ

metaM btn c
is: HMDB00030
boundary condition: false
is: CHEBI:3420
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Biotin
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
is: C00120

metaM frdp x
type: Species
boundary condition: false
is: HMDB00961
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: farnesyl pyrophosphate(3-)
constant: false
is: CHEBI:175763
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaM so4 c
has only substance units: false
name: sulfate
boundary condition: false
type: Species
is: HMDB01448
constant: false
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16189

metaR P4508B11r
kinetic law: MODEL1310110013#
name: sterol 12-alpha-hydroxylase
is: SBO:0000176
fast: false
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.95
is described by: ECO:0000269
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_c21c9804_a196_4a90_b2eb_ba9a1a771fdc
constant: false
initial concentration: NaN
type: Species
name: GNS
boundary condition: true
is: Q7Z3X3
has only substance units: false
is encoded by: hsa:2799
is: SBO:0000252
initial amount: NaN

metaR VITD3t2
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
reversible: false
fast: false
name: Vitamin D3 uptake
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
reactant: MODEL1310110013#

metaR URIK1
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
fast: false
reactant: MODEL1310110013#
is described by: ECO:0000269
name: uridine kinase (ATP:Uridine)
type: Reaction
reversible: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.48

metaR NDPK6m
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
product: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
reversible: true
is described by: ECO:0000254
is: SBO:0000176

metaR DNDPt15m
modifier: MODEL1310110013#
fast: false
is described by: ECO:0000269
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reversible: false
name: dUDP transport via dGDP antiport

http://identifiers.org/biomodels.db/MODEL1310110013#_2f8ba231_c5af_4f9b_a650_b438562b0f4c
initial concentration: NaN
is encoded by: hsa:5277
constant: false
boundary condition: true
name: PIGA
has only substance units: false
type: Species
initial amount: NaN
is: B3KUV7
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_b26589d8_762d_4270_b560_0cb20b915ec5
boundary condition: true
has only substance units: false
is encoded by: hsa:8854
is: O94788
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: ALDH1A2

metaM mal L m
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:15589
is: HMDB00156
name: (S)-malate(2-)
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146

metaM citr L m
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349
name: L-citrulline
has only substance units: false
is: HMDB00904
type: Species
initial amount: NaN
boundary condition: false

metaM dha e
initial amount: NaN
is: SBO:0000247
type: Species
name: glycerone
has only substance units: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: HMDB01882
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16016

metaR FAOXC226C227m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_349c57c3_78a9_4343_a9f9_e2e3518206cb
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:1346
is: P24310
name: COX7A1
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR ASPPROASCT1
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: aspartate intake by system ASCT-1 transporter
is: SBO:0000185
reversible: false
reactant: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaR MI134P4P
reactant: MODEL1310110013#
fast: false
reversible: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
name: inositol-1,3,4-trisphosphate 4-phosphatase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is described by: ECO:0000000

metaM lnlnca e
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: alpha-linolenate
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388
boundary condition: false
constant: false
is: CHEBI:32387

metaR GSNt4
name: guanosine transport in via sodium symport
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (9153.1) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#

metaM tsul m
name: thiosulfate(2-)
is: CHEBI:16094
is: HMDB00257
initial amount: NaN
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM bilirub e
initial amount: NaN
is: HMDB00054
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
name: bilirubin(2-)
is: CHEBI:57977
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ac78da8e_c3c5_4b1f_bace_8f7acd2b6e63
is: SBO:0000252
initial amount: NaN
is: Q8N9L9
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:122970
type: Species
name: ACOT4

http://identifiers.org/biomodels.db/MODEL1310110013#_0aa9959e_5225_4e5c_9ef4_73be94f3f65e
boundary condition: true
is encoded by: hsa:6578
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q92959
name: SLCO2A1

http://identifiers.org/biomodels.db/MODEL1310110013#_39c46240_6384_41b0_b6dd_ae693db342ff
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
name: OCRL
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:4952

http://identifiers.org/biomodels.db/MODEL1310110013#_14b7c7e4_44b2_420f_8f25_f6a866ec2d92
initial amount: NaN
is encoded by: hsa:64077
name: LHPP
type: Species
initial concentration: NaN
boundary condition: true
is: Q9H008
is: SBO:0000252
has only substance units: false
constant: false

metaM adrncoa c
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: adrenyl coenzyme A
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
is: C16170

http://identifiers.org/biomodels.db/MODEL1310110013#_746d8c99_72d1_4124_ac2f_19d979a22d5e
is: SBO:0000252
name: SLC27A2
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:11001
constant: false
initial amount: NaN
is: O14975
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_40bbc3f8_da2a_4d0f_b99b_c54a87cdb6b3
name: GUCY1A2
constant: false
has only substance units: false
is encoded by: hsa:2977
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P33402
type: Species
boundary condition: true

metaM cholate e
is: HMDB00619
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
boundary condition: false
is: CHEBI:29747
constant: false
name: Cholate
initial concentration: 1.0
type: Species
has only substance units: false

metaM alpam m
type: Species
initial amount: NaN
is: HMDB06239
has only substance units: false
is: SBO:0000247
name: S-aminomethyldihydrolipoamide
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_0253889e_7fa5_4d22_a73f_8d3a02433145
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: FLAD1
is: Q8NFF5
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:80308
constant: false

metaM gthox m
is: HMDB03337
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:58297
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
initial amount: NaN
type: Species

metaM 4hexdtricoa m
name: 4,7,10-hexadecatrienoylcoa
initial amount: NaN
initial concentration: 1.0
is: HMDB02288
constant: false
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110013#_1dc70cd9_8c83_4eeb_b3e9_c0e1ee6172d3
is: SBO:0000297
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: B4GALT1:LALBA
has part: P00709
is encoded by: hsa:3906
has part: P15291
initial concentration: NaN
is encoded by: hsa:2683
boundary condition: true

metaM fald e
is: CHEBI:16842
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01426
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
name: formaldehyde

metaM atp r
boundary condition: false
is: CHEBI:57299
has only substance units: false
is: HMDB00538
name: ATP(4-)
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00002
type: Species

metaR CERT1gt
is described by: ECO:0000304
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
name: ceramide transport protein
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

http://identifiers.org/biomodels.db/MODEL1310110013#_0876c9b1_d5ed_4c63_9ffc_1ce49fd4389d
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: HAO2
is encoded by: hsa:51179
is: Q9NYQ3
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaR DGK1
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
name: deoxyguanylate kinase (dGMP:ATP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110013#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.8
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_6cf2afa9_d3f4_4e92_9483_adc41a358dfd
is encoded by: hsa:9194
has only substance units: false
initial concentration: NaN
constant: false
name: SLC16A7
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q8NEM3

http://identifiers.org/biomodels.db/MODEL1310110013#_9c845f10_41a0_4b3a_ba8e_ba3949d66dc1
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: TXNRD1
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:7296

metaR DADNt4
reactant: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: deoxyadenosine transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true

metaM chsterol e
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
name: cholesterol
is: CHEBI:16113
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_a2c552c4_743e_4fba_8f84_6c1bcc011af7
boundary condition: true
initial amount: NaN
is encoded by: hsa:218
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ALDH3A1
is: P30838
type: Species
constant: false

metaM chsterol c
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00067
constant: false
initial amount: NaN
is: CHEBI:16113

http://identifiers.org/biomodels.db/MODEL1310110013#_e4136bb7_cd27_4a5a_97c6_b2bbdedb37e5
name: DGKH
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:160851
initial concentration: NaN
has only substance units: false
is: Q86XP1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_b2eaeda4_1b35_421b_bb1a_938cb30c76a4
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
name: SLC15A2
initial amount: NaN
is encoded by: hsa:6565
is: Q16348

metaM c4crn c
has only substance units: false
initial amount: NaN
name: butyryl carnitine
initial concentration: 1.0
is: SBO:0000247
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
type: Species
constant: false
is: C02862
notes: FORMULA: C11H21NO4 CHARGE: 0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_84b25660_63b1_4d05_8d05_aa2f22e213a1
is encoded by: hsa:57379
name: AICDA
is: Q546Y9
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_43126b13_0121_4e32_8f37_79ec32bff5b8
is: B7Z9T9
has only substance units: false
is encoded by: hsa:5158
initial concentration: NaN
boundary condition: true
type: Species
constant: false
name: PDE6B
initial amount: NaN
is: SBO:0000252

metaR r0208
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.4.1.1
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reactant: MODEL1310110013#
type: Reaction
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110013#
product: MODEL1310110013#

metaM 5mthf c
initial amount: NaN
constant: false
is: CHEBI:3729
name: 5-Methyltetrahydrofolate
is: HMDB01396
notes: FORMULA: C20H24N7O6 CHARGE: -1
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: C00440
is: SBO:0000247

metaM 3mgcoa m
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: HMDB01057
is: CHEBI:57346
boundary condition: false
name: trans-3-methylglutaconyl-CoA(5-)

metaM cholate c
name: Cholate
constant: false
is: HMDB00619
is: CHEBI:29747
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaM malcoa c
constant: false
name: Malonyl-CoA
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00083
has only substance units: false
initial concentration: 1.0
is: HMDB01175
type: Species

metaM so4 m
is: SBO:0000247
name: sulfate
type: Species
is: HMDB01448
initial concentration: 1.0
is: CHEBI:16189
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_2338d298_b653_4191_8c67_38edd7235cc3
boundary condition: true
type: Species
is encoded by: hsa:3098
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: HK1
is: Q59FD4

metaM ksi deg24 l
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:12936
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
is: HMDB00143
name: keratan sulfate I, degradation product 24
boundary condition: false

metaM tetpent3 c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: tetracosapentaenoic acid, n-3
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB06323
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_269f3306_9862_4bff_9343_b6f25f0f99a5
type: Species
initial amount: NaN
constant: false
name: NDUFA7
boundary condition: true
is encoded by: hsa:4701
initial concentration: NaN
has only substance units: false
is: Q6FG42
is: SBO:0000252

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

metaM pail345p hs c
boundary condition: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial amount: NaN
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
type: Species
is: CHEBI:57836
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM c4crn e
is: http://identifiers.org/pubchem.compound/213144
is: HMDB02013
notes: FORMULA: C11H21NO4 CHARGE: 0
initial concentration: 1.0
is: C02862
is: SBO:0000247
boundary condition: false
has only substance units: false
name: butyryl carnitine
type: Species
initial amount: NaN
constant: false

metaR ACACT10m
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000176

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM so4 l
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
type: Species
is: HMDB01448
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:16189

metaM Sfglutth c
initial concentration: 1.0
name: S-formylglutathionate(1-)
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: CHEBI:57688
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01550
initial amount: NaN
constant: false

metaM 5mthf e
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: SBO:0000247
name: 5-Methyltetrahydrofolate
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:3729
initial concentration: 1.0
is: C00440
is: HMDB01396
initial amount: NaN

metaR C4tcx
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_08e81169_e672_4d8e_866e_8136afb01ba9
initial amount: NaN
is encoded by: hsa:10935
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: P30048
constant: false
name: PRDX3

metaR ACGPID
kinetic law: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.89
modifier: MODEL1310110013#
is: SBO:0000176
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000269
name: N-acetylglucosaminylphosphatidylinositol deacetylase

metaM succ e
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:30031
name: succinate(2-)
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
initial concentration: 1.0
type: Species

metaR FAOXC12C10x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

metaR AKGMALtm
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
reversible: true
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000269
name: alpha-ketoglutarate/malate transporter
is: SBO:0000185
fast: false
reactant: MODEL1310110013#

metaM 4hexdtricoa x
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
name: 4,7,10-hexadecatrienoylcoa
is: HMDB02288
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_18920b5b_684f_4b1d_a976_82accbc942ac
is: SBO:0000252
type: Species
is: Q6NSB3
constant: false
is encoded by: hsa:276
has only substance units: false
boundary condition: true
initial amount: NaN
name: AMY1A
initial concentration: NaN

metaM citr L c
is: CHEBI:16349
boundary condition: false
is: HMDB00904
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
constant: false
name: L-citrulline
has only substance units: false

metaR FACOAL170
type: Reaction
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
name: fatty-acid--CoA ligase
product: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaM mal L c
is: CHEBI:15589
initial concentration: 1.0
is: HMDB00156
has only substance units: false
name: (S)-malate(2-)
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_682ef421_1b12_4319_b8b4_a06623fe795c
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3074
type: Species
constant: false
is: P07686
has only substance units: false
name: HEXB

metaM tsul c
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:16094
boundary condition: false
name: thiosulfate(2-)
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
initial concentration: 1.0
is: HMDB00257
is: SBO:0000247
type: Species

metaM malcoa e
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57384
is: HMDB01175
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial concentration: 1.0

metaR LEUKTRF4t
type: Reaction
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
name: leukotriene F4 transport
fast: false
is described by: ECO:0000000

metaR O2ter
product: MODEL1310110013#
name: O2 transport, endoplasmic reticulum
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000000

metaM tetpent3 e
constant: false
initial amount: NaN
is: HMDB06323
has only substance units: false
boundary condition: false
type: Species
name: tetracosapentaenoic acid, n-3
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM btn e
name: Biotin
boundary condition: false
constant: false
is: HMDB00030
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: C00120
is: CHEBI:3420

metaM acglcgalgluside hs g
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
has only substance units: false
is: CHEBI:17103
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
constant: false

metaM atp x
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00538
boundary condition: false
is: CHEBI:57299
is: C00002
constant: false
name: ATP(4-)
type: Species

metaR RE3628M
modifier: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
kinetic law: MODEL1310110013#
name: RE3628
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_d20689b1_b572_4b29_a732_618f6c98ecd0
has only substance units: false
is encoded by: hsa:5210
is: Q16877
name: PFKFB4
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaM 2docohexecoa m
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
name: 2,7,10,13,16,19-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ac994846_02fc_4c54_8d86_20631e38bbf8
type: Species
name: PDE4B
is encoded by: hsa:5142
initial concentration: NaN
is: SBO:0000252
is: Q5TEK5
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_c74fab11_456f_4ab3_9d82_5f6a09c0afef
type: Species
is encoded by: hsa:1553
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: Q16696
name: CYP2A13
initial amount: NaN
initial concentration: NaN

metaM succ c
boundary condition: false
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
is: C00042
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: Succinate
is: HMDB00254
is: CHEBI:30031

metaR r2329
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#

metaM citr L e
has only substance units: false
is: HMDB00904
name: citr_L[e]
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:16349
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

metaM lneldc e
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
is: HMDB06270
initial concentration: 1.0
name: linoelaidic acid (all trans C18:2)
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

metaM ttdca c
is: HMDB00806
has only substance units: false
initial amount: NaN
is: CHEBI:30807
initial concentration: 1.0
is: SBO:0000247
name: myristate
type: Species
constant: false
boundary condition: false
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_02ddeb52_4ca9_498d_9a21_73d732b98e0d
initial concentration: NaN
name: _AW277253_1_c
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AW277253
initial amount: NaN
constant: false
type: Species

metaM acgpail hs c
is: CHEBI:57265
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
boundary condition: false
is: SBO:0000247
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)

metaR NACHEX17ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110013#

metaM frdp r
constant: false
is: C00448
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
is: HMDB00961
name: Farnesyl diphosphate
initial concentration: 1.0
type: Species
initial amount: NaN

metaM Rtotal2 e
is: C00255
initial concentration: 1.0
is: CHEBI:3554
boundary condition: false
is: SBO:0000247
notes: FORMULA: CO2FULLR2 CHARGE: -1
has only substance units: false
name: R total 2 position
is: HMDB00244
initial amount: NaN
constant: false
type: Species

metaM 4ppcys m
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: CHEBI:59458
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: SBO:0000247

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_76c157b4_8657_4fef_8151_f1cacc06905e
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:50
initial amount: NaN
constant: false
is: Q99798
name: ACO2
has only substance units: false
initial concentration: NaN

metaR RBFK
reversible: false
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.26
modifier: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
reactant: MODEL1310110013#
name: riboflavin kinase

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_41dd768f_6611_4f54_beae_f48803dc6398
is: SBO:0000252
name: _T83654_1_c
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:T83654
initial amount: NaN

metaM lneldc c
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB06270
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
name: linoelaidic acid (all trans C18:2)

http://identifiers.org/biomodels.db/MODEL1310110013#_82932dfe_2846_4774_a340_6ccf82261b61
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is: P15531
constant: false
name: NME1
type: Species
is encoded by: hsa:4830
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_327d3a12_01ff_4421_8b02_1890faa8641a
is: B1AM93
initial amount: NaN
name: NDUFA8
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4702
has only substance units: false
boundary condition: true

metaM HC01496 m
name: 2-Amino-3-oxoadipate
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial concentration: 1.0
is: CHEBI:28095
has only substance units: false

metaM ttdca e
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:30807
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
type: Species
name: tetradecanoate (n-C14:0)
boundary condition: false
initial concentration: 1.0
is: C06424
has only substance units: false
is: HMDB00806

metaR SIAASE3ly
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
modifier: MODEL1310110013#
product: MODEL1310110013#

metaR r0789
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR r0917
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaM rbt e
initial concentration: 1.0
is: CHEBI:15963
type: Species
constant: false
has only substance units: false
boundary condition: false
name: D-ribitol
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
is: SBO:0000247

metaM f6p c
is: HMDB00124
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3385
is: C00085
name: D-Fructose 6-phosphate
initial amount: NaN
is: CHEBI:57579

metaR RE3241R
fast: false
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
type: Reaction
is described by: ECO:0000000
name: RE3241
product: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
reversible: false

metaR r0355
is version of: http://identifiers.org/ec-code/4.2.1.3
modifier: MODEL1310110013#
is: SBO:0000176
reversible: false
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaR SPHS1Pte
reactant: MODEL1310110013#
reversible: true
name: sphingosine-1-phosphate transport
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ

metaM no c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16480
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
constant: false
initial amount: NaN
is: HMDB03378
type: Species
is: C00533
boundary condition: false
has only substance units: false

metaM 4mop e
has only substance units: false
is: HMDB00695
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
constant: false

metaM gbside hs g
constant: false
name: globoside
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: CHEBI:18259
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_038decfb_4210_423e_9ea9_5b64458fb830
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110013#_a1c08a4a_ab6b_4799_a2b1_36c0c51f6a65
has only substance units: false
name: FOLR1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2348
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaR TAGt
name: triacylglycerol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_ccd28046_5dcf_432c_9269_595251c49974
type: Species
boundary condition: true
constant: false
is encoded by: hsa:1719
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: DHFR
is: P00374
has only substance units: false

metaR CMPSAS
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110013#
is described by: ECO:0000304
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.43
reactant: MODEL1310110013#
name: CMP sialic acid synthase

metaM chsterol l
name: cholesterol
type: Species
has only substance units: false
is: CHEBI:16113
is: HMDB00067
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaM no e
type: Species
boundary condition: false
is: HMDB03378
is: C00533
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:16480
name: Nitric oxide

metaM rbt c
has only substance units: false
is: CHEBI:15963
type: Species
boundary condition: false
constant: false
name: D-ribitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
initial amount: NaN
is: HMDB00508
is: SBO:0000247
initial concentration: 1.0

metaR r0915
fast: false
product: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r2014
is described by: ECO:0000000
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110013#
type: Reaction

metaR IMPC
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.1.2.3
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110013#
reversible: true
name: IMP cyclohydrolase

metaM xyl D l
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0
is: CHEBI:15936
type: Species
constant: false
name: aldehydo-D-xylose
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR r0630
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.3.1
reversible: true
kinetic law: MODEL1310110013#
is: SBO:0000176
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.3.2
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:

metaR r1291
reversible: true
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_81ee2d53_159d_4707_8d90_d8d2a9858c27
is encoded by: hsa:2752
has only substance units: false
boundary condition: true
name: GLUL
is: SBO:0000252
is: P15104
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_172575a9_40c9_41ad_9423_956447a53b84
initial concentration: NaN
is: Q7Z3N0
has only substance units: false
initial amount: NaN
name: CYP3A5
is encoded by: hsa:1577
type: Species
constant: false
boundary condition: true
is: SBO:0000252

metaM 4mop c
constant: false
name: 4-methyl-2-oxopentanoate
initial concentration: 1.0
is: HMDB00695
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
has only substance units: false

metaM chsterol m
is: CHEBI:16113
boundary condition: false
is: SBO:0000247
constant: false
name: cholesterol
is: HMDB00067
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species
initial concentration: 1.0
has only substance units: false

metaR r2015
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110013#
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#

metaR r0354
fast: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
reversible: false
product: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaR FACOAL150
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
name: fatty-acid--CoA ligase

metaR FAOXC123C102m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_e7e3e28c_71dc_4b57_96a5_6068cd6cb9b1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is: Q2TU34
constant: false
name: FBP1
boundary condition: true
is encoded by: hsa:2203

http://identifiers.org/biomodels.db/MODEL1310110013#_ab45b0a2_1dce_40e4_b7e9_7302f80274a8
name: GUCY1B3
type: Species
is: Q02153
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2983
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r2347
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110013#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110013#
fast: false

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaM glyc c
name: Glycerol
constant: false
is: HMDB00131
initial amount: NaN
is: C00116
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:17754

metaR NAHCO3 HCLt
name: bicarbonate transport (HCl/NaHCO3 exchange)
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
fast: false
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#

metaM glu L e
initial amount: NaN
is: CHEBI:29985
name: L-glutamate(1-)
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00148

http://identifiers.org/biomodels.db/MODEL1310110013#_f9eeecfb_6777_42e7_9fb4_2128ecb41e6e
is: SBO:0000252
constant: false
name: GGH
boundary condition: true
type: Species
initial concentration: NaN
is: Q92820
has only substance units: false
initial amount: NaN
is encoded by: hsa:8836

metaM pro D c
name: D-proline
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB03411
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: CHEBI:16313
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_82057feb_1688_4e70_aa8e_d53984c641af
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:155184
type: Species
name: SLC2A7
is: SBO:0000252
initial amount: NaN
is: Q6PXP3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_bca4ee4b_9fcc_43f2_bf52_be8987b40b45
initial amount: NaN
is: P09622
constant: false
is encoded by: hsa:1738
name: DLD
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR C14STRr
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
name: C-14 sterol reductase
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.70
reversible: false
product: MODEL1310110013#
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_66948358_bf14_4c42_9245_d7edeb2d20e8
name: ST3GAL2
has only substance units: false
boundary condition: true
is encoded by: hsa:6483
initial concentration: NaN
initial amount: NaN
constant: false
is: Q16842
type: Species
is: SBO:0000252

metaR RE1845X
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
is described by: ECO:0000000
modifier: MODEL1310110013#
fast: false
is: SBO:0000176
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
reversible: true
name: RE1845
is version of: http://identifiers.org/ec-code/2.3.1.65

metaM acac c
is: HMDB00060
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
type: Species
is: CHEBI:13705
name: acetoacetate

metaM prgnlone c
is: SBO:0000247
initial concentration: 1.0
is: HMDB00253
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
name: pregnenolone
initial amount: NaN
is: CHEBI:16581
has only substance units: false
type: Species
boundary condition: false
constant: false

metaR KSItly
kinetic law: MODEL1310110013#
type: Reaction
name: keratan sulfate I transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
is: SBO:0000185
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_443a8c30_f407_47d0_96ba_d324ae17e873
is: SBO:0000297
is encoded by: hsa:518
has part: P48201
initial concentration: NaN
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2

metaM arab L c
is: SBO:0000247
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: CHEBI:30849
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_df046167_ef0b_4976_8e6f_f3319b15dbd3
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: _W74642_1_c
is encoded by: hsa:W74642
initial concentration: NaN

metaR r1292
fast: false
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110013#
type: Reaction

metaM prpp c
initial amount: NaN
has only substance units: false
is: HMDB00280
type: Species
boundary condition: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: CHEBI:58017
initial concentration: 1.0
is: SBO:0000247
constant: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: C00119

metaR UAGALDP
reversible: false
type: Reaction
name: UDP-N-acetylgalactosamine diphosphorylase
product: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_c754ae99_8011_43ea_b613_5dc1c4a0f3b2
is: SBO:0000252
type: Species
name: PEMT
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:10400
initial amount: NaN

metaR r1052
name: Vesicular transport
is described by: ECO:0000000
reactant: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:

metaR C226CRNt
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: false
name: C226 transport into the mitochondria
is described by: ECO:0000000

metaR RE3421R
name: RE3421
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reversible: true

metaR r2010
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaR 3HCO3 NAt
reactant: MODEL1310110013#
product: MODEL1310110013#
name: 3HCO3_NAt
fast: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110013#

metaM paps g
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:58339
initial amount: NaN
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: SBO:0000247
boundary condition: false
constant: false

metaR BILGLCURtr
reversible: true
reactant: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport
type: Reaction

metaM f1p c
is: HMDB01076
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
constant: false
initial amount: NaN
is: CHEBI:18105
has only substance units: false
type: Species
name: D-Fructose 1-phosphate
is: C01094
is: SBO:0000247
boundary condition: false

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR GPIAT
modifier: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: false
type: Reaction
name: glucosaminylphosphatidyl inositol acetyltransferase
fast: false
is described by: ECO:0000269

metaM pro D e
name: D-proline
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false
initial concentration: 1.0
is: CHEBI:16313
has only substance units: false
type: Species
is: HMDB03411

metaR r1051
is: SBO:0000185
fast: false
product: MODEL1310110013#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
type: Reaction
name: Vesicular transport
reactant: MODEL1310110013#

metaM acac e
is: SBO:0000247
has only substance units: false
boundary condition: false
name: acetoacetate
initial amount: NaN
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
initial concentration: 1.0
is: CHEBI:13705
is: HMDB00060

http://identifiers.org/biomodels.db/MODEL1310110013#_155dbac6_8f5e_42fc_99a0_a72a398d038f
name: PLCD4
constant: false
is: SBO:0000252
is: Q9BRC7
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:84812
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_104200cb_c2a9_420f_916c_3e8c0968aaae
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:6818
initial concentration: NaN
name: SULT1A3

metaR HEX10
reversible: false
kinetic law: MODEL1310110013#
is described by: ECO:0000212
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
reactant: MODEL1310110013#
name: hexokinase (D-glucosamine:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1

http://identifiers.org/biomodels.db/MODEL1310110013#_47b7665c_81e0_4e8c_bd97_1487b018afb6
boundary condition: true
is encoded by: hsa:594
has only substance units: false
name: DBT:DLD:BCKDHA:BCKDHB
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
has part: Q9BQL0
constant: false

metaM prpp e
is: HMDB00280
type: Species
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:58017
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)

metaR r2346
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
name: Organic anion transporter 5 Utilized transport
type: Reaction

metaR r1050
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110013#
type: Reaction
name: Vesicular transport
reversible: true

metaR URIt4
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
fast: false
type: Reaction
reactant: MODEL1310110013#
name: uridine transport in via sodium symport
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
is: SBO:0000185

metaM ins e
name: Inosine
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial amount: NaN
has only substance units: false
is: CHEBI:17596
initial concentration: 1.0
is: C00294
is: SBO:0000247
constant: false
type: Species
is: HMDB00195
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_73b65b2a_3a74_4c43_8fcf_3c4121c0c8cd
has only substance units: false
name: B3GNT3
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9Y2A9
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10331
constant: false

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaM hexc e
is: CHEBI:31013
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
name: cerotate
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB02356
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1

metaM dhcholoylcoa x
is: HMDB06895
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27393
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
type: Species
constant: false
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110013#_39fc7efb_d1ae_4b69_98c9_7aa2f72fd164
type: Species
is: SBO:0000252
is encoded by: hsa:374291
initial concentration: NaN
constant: false
boundary condition: true
name: NDUFS7
initial amount: NaN
has only substance units: false
is: O75251

metaR OROTGLUt
reversible: true
kinetic law: MODEL1310110013#
name: OROTGLUt
is described by: ECO:0000134
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaM lald D c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: CHEBI:17167
name: (R)-lactaldehyde
constant: false
type: Species
is: HMDB06458
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM ksi deg23 l
is: CHEBI:12936
is: HMDB00143
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
name: keratan sulfate I, degradation product 23

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_acfdef62_8f11_4bf5_9b7e_b0a8e56df6e5
initial amount: NaN
is encoded by: hsa:30
constant: false
has only substance units: false
type: Species
is: Q96CA6
is: SBO:0000252
boundary condition: true
name: ACAA1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_90e17b4b_bd2f_4a8b_b4d9_5d8f64cb23b4
is: SBO:0000252
boundary condition: true
constant: false
is: Q13011
has only substance units: false
initial amount: NaN
type: Species
name: ECH1
initial concentration: NaN
is encoded by: hsa:1891

metaR r2344
reactant: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

metaR TAURCHAe
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14992263 NOTES:taurine is an osmolyte that aids in osmoregulation. Reactive oxygen species (ROS) and eicosanoids activate tyrosine-kinase cascade, resulting in activation of volume sensitive taurine channel. Further ROS causes membrane permeabilization that results in taruine loss.
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: false
name: exit of taurine from the enterocytes
product: MODEL1310110013#

metaR TETTET6t
name: fatty acid transport via diffusion
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#

metaR PI45PLC
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
fast: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110013#
type: Reaction
reversible: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM xoltriol c
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16496
is: HMDB01457
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
has only substance units: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol

http://identifiers.org/biomodels.db/MODEL1310110013#_86f2ccda_2f36_4103_b5be_3131284afa39
is: SBO:0000252
is encoded by: hsa:9023
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: O95992
initial amount: NaN
name: CH25H

metaM xoldiolone r
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB02197
is: CHEBI:28477
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
boundary condition: false
type: Species
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

metaM ksi deg13 l
has only substance units: false
is: HMDB01354
is: SBO:0000247
is: CHEBI:57455
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: keratan sulfate I, degradation product 13
boundary condition: false
notes: FORMULA: C174H280N12O150S8 CHARGE: -8

metaM ins c
name: Inosine
is: C00294
boundary condition: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
constant: false
type: Species
is: SBO:0000247
is: HMDB00195
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17596
has only substance units: false

metaM hdcea c
is: CHEBI:32372
name: Hexadecenoate (n-C16:1)
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB03229
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

metaM glu L c
is: SBO:0000247
name: L-glutamate(1-)
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false
initial concentration: 1.0
type: Species
is: HMDB00148
initial amount: NaN
boundary condition: false
is: CHEBI:29985

metaR r2341
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
type: Reaction

metaR EHGLATm
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
type: Reaction
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
reversible: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110013#
is: SBO:0000176
fast: false
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_8f1630af_9216_4e1f_a16a_10047ad2ba4f
initial concentration: NaN
is: SBO:0000252
constant: false
is: G3XAJ0
has only substance units: false
type: Species
boundary condition: true
name: ACAD10
initial amount: NaN
is encoded by: hsa:80724

metaR r0783
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
modifier: MODEL1310110013#
fast: false
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true

metaM glyc e
is: C00116
name: Glycerol
is: HMDB00131
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17754
type: Species
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116

metaR GLNtm
is: SBO:0000185
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
reversible: false
name: L-glutamine transport via electroneutral transporter
product: MODEL1310110013#

metaR r0638
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.8.1.2
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000000
fast: false

metaM hexc c
is: HMDB02356
type: Species
constant: false
is: CHEBI:31013
is: SBO:0000247
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
name: cerotate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false

metaM dhcrm hs c
initial concentration: 1.0
has only substance units: false
is: CHEBI:31488
type: Species
is: SBO:0000247
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
initial amount: NaN
constant: false
boundary condition: false
name: dihydroceramide

metaR MAL Lte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
name: Transport of L-malate
is: SBO:0000185
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_bf3a06e7_cd2f_41a1_a6d1_a084e341c43c
is encoded by: hsa:768
boundary condition: true
has only substance units: false
is: Q16790
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
name: CA9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_a9583b86_13e8_4c80_9205_bb8da8b2a160
constant: false
is: SBO:0000252
name: CPT1B
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1375
has only substance units: false
is: B7Z5T8

http://identifiers.org/biomodels.db/MODEL1310110013#_2c2a801c_2e18_4873_8f02_43a1d3e56854
name: PLCZ1
type: Species
has only substance units: false
is: Q86YW0
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:89869
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_ca19364c_a39b_4dea_b2d7_798690361454
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ADCY6
constant: false
boundary condition: true
is encoded by: hsa:112

metaM 6dhf e
constant: false
initial amount: NaN
is: HMDB06563
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
type: Species
initial concentration: 1.0
name: hexaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110013#_5925988a_4592_46dd_9747_cd554a421011
type: Species
boundary condition: true
initial concentration: NaN
is: Q9Y217
name: MTMR6
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:9107
initial amount: NaN

metaR EX CE1925 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-carboxy-alpha-chromanol exchange
type: Reaction

metaR r0784
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is: SBO:0000176
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
is version of: http://identifiers.org/ec-code/1.3.1.38
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_eac3e1e5_6c23_4bd4_aa9d_01712f5fbefd
type: Species
has only substance units: false
is: SBO:0000252
name: ADCY3
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:109
initial concentration: NaN
is: B3KT86

metaM arab L e
is: HMDB00646
initial amount: NaN
is: CHEBI:30849
name: L-arabinose
notes: FORMULA: C5H10O5 CHARGE: 0
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR r0639
is: SBO:0000176
product: MODEL1310110013#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR AMETtd
name: diffusion of S-Adenosyl-L-methionine
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000134
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaM 3dodtricoa x
is: HMDB11123
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: 3,6,9-dodecatrienoylcoa
constant: false
is: SBO:0000247
is: C05279
type: Species
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_942c551a_794d_4dde_9720_740d9c9ba5c0
boundary condition: true
has only substance units: false
type: Species
constant: false
is encoded by: hsa:622
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: BDH1
is: Q02338

http://identifiers.org/biomodels.db/MODEL1310110013#_67e611cc_b4a2_487d_9e34_b5bfa1f8c1e6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:223
constant: false
name: ALDH9A1
type: Species
boundary condition: true
initial concentration: NaN
is: P49189
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_f4f879c7_bb98_44ce_aa85_e6a2a9c9be63
is: P49619
is: SBO:0000252
type: Species
name: DGKG
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1608
constant: false

metaM hdcea e
name: Hexadecenoate (n-C16:1)
has only substance units: false
is: CHEBI:32372
boundary condition: false
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_b48134e1_c318_432a_99c4_fdf4ffeaa0be
name: ELOVL5
type: Species
is: F6SH78
has only substance units: false
boundary condition: true
is encoded by: hsa:60481
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252

metaM chsterol r
type: Species
initial concentration: 1.0
name: cholesterol
is: CHEBI:16113
is: HMDB00067
initial amount: NaN
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_65892169_0157_4397_879a_15416c5c3752
is encoded by: hsa:22305
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: _22305_2_c

metaR GTHRDt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reactant: MODEL1310110013#
name: Glutathione transport into mitochondria
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
fast: false

metaM ps hs c
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: ps_hs[c]
is: CHEBI:18303
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_536fb1e8_b394_4396_b75c_678354a766cd
initial concentration: NaN
constant: false
is: P04062
has only substance units: false
is: SBO:0000252
name: GBA
is encoded by: hsa:2629
initial amount: NaN
type: Species
boundary condition: true

metaM HC00229 e
initial concentration: 1.0
is: CHEBI:28189
boundary condition: false
name: Isomaltose
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species

metaR r0913
kinetic law: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110013#

metaM arachdcrn c
is: HMDB01322
type: Species
name: C20:4 carnitine
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57387
is: SBO:0000247
constant: false

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_35c0d78d_f961_4d30_a70f_ab4934ddd4e9
name: _AI656480_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:AI656480
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaR CYTDt4
reactant: MODEL1310110013#
name: cytidine transport in via sodium symport
product: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
reversible: false
fast: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_75179180_762f_46bb_888d_ad099214a3ea
type: Species
name: RDH14
is encoded by: hsa:57665
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q9HBH5
has only substance units: false
constant: false

metaM c4crn x
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: C02862
initial concentration: 1.0
name: butyryl carnitine
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
type: Species
is: SBO:0000247
constant: false
is: HMDB02013

metaM CE5160 r
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
name: 3-oxo-cis-9-octadecenoyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110013#_de5b7f1d_bbf4_4de8_87b1_fec04be4af90
boundary condition: true
name: PPCS
is: Q9HAB8
is encoded by: hsa:79717
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

metaM glyc m
is: C00116
name: Glycerol
is: HMDB00131
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_407a21e3_e85b_4cdd_be8a_b1024cdd7f7a
initial concentration: NaN
type: Species
name: GALNT14
boundary condition: true
is: Q96FL9
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79623

metaR r0633
is version of: http://identifiers.org/ec-code/2.7.7.3
is: SBO:0000176
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
reactant: MODEL1310110013#

metaR RDH2a
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.300
kinetic law: MODEL1310110013#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
name: retinol dehydrogenase (9-cis,NADPH)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
reversible: true

metaM mescon m
is: CHEBI:36986
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
initial amount: NaN
name: Mesaconate
has only substance units: false
is: HMDB00749
constant: false
type: Species
is: SBO:0000247

metaR r2018
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
kinetic law: MODEL1310110013#
fast: false
reversible: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000000

metaR ABTArm
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.19
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
is described by: ECO:0000269
modifier: MODEL1310110013#

metaR PRISTCOAtcx
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR FAOXC170m
type: Reaction
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
name: Beta oxidation of long chain fatty acid (odd chain)

metaR r0787
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000000
modifier: MODEL1310110013#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
kinetic law: MODEL1310110013#

metaR r0634
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
modifier: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.1

metaR r0911
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
name: Facilitated diffusion
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

metaR NACHEX16ly
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110013#
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_6fa61eeb_f04f_4c9a_b54b_c1b860817eee
is: P09972
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:230
type: Species
is: SBO:0000252
name: ALDOC
has only substance units: false
constant: false

metaR GASNASE3ly
is: SBO:0000176
product: MODEL1310110013#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110013#
reversible: false
name: glycosylasparaginase, lysosomal
is version of: http://identifiers.org/ec-code/3.5.1.26
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110013#_6c4dd661_2915_4c2e_846d_d133710086c7
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3098
constant: false
has only substance units: false
initial amount: NaN
is: B3KXY9
is: SBO:0000252
type: Species
name: HK1

metaM cs a deg4 l
boundary condition: false
is: HMDB01354
has only substance units: false
type: Species
initial amount: NaN
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
initial concentration: 1.0
notes: FORMULA: C31H49NO29S CHARGE: -2
is: CHEBI:57455
is: SBO:0000247
constant: false

metaM prgnlone m
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
is: SBO:0000247
boundary condition: false
name: pregnenolone
type: Species
is: CHEBI:16581
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00253
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_70c93b4a_cf0f_4065_bc0e_ef84f72e058e
is encoded by: hsa:2639
type: Species
has only substance units: false
boundary condition: true
is: Q92947
constant: false
is: SBO:0000252
initial concentration: NaN
name: GCDH
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c6abc2ce_3b78_49f1_b447_b964433fa608
initial concentration: NaN
is: Q9P212
constant: false
is: SBO:0000252
initial amount: NaN
name: PLCE1
is encoded by: hsa:51196
boundary condition: true
type: Species
has only substance units: false

metaR r0788
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.14.13.15
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110013#
fast: false
type: Reaction
product: MODEL1310110013#

metaR DNDPt16m
reactant: MODEL1310110013#
reversible: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
name: dUDP transport via dADP antiport
modifier: MODEL1310110013#
is described by: ECO:0000269
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185

metaR ABUTt2r
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
modifier: MODEL1310110013#
product: MODEL1310110013#
name: 4-aminobutyrate reversible transport in via proton symport
is: SBO:0000185
type: Reaction
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110013#_4e9a59e1_ef47_4840_9cdb_2c81b07994ed
is: SBO:0000252
name: _728226_1_m
has only substance units: false
initial concentration: NaN
is encoded by: hsa:728226
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR LYStn
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
name: L-lysine transport, nuclear
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110013#
is described by: ECO:0000000

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR 3HBCOAHLm
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is described by: ECO:0000000

metaR GALASE4ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4728a29a_6663_42e1_ba2f_037019a4bb76
is: SBO:0000252
initial concentration: NaN
is: Q9UKG4
has only substance units: false
constant: false
name: SLC13A4
initial amount: NaN
type: Species
is encoded by: hsa:26266
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_ef6949f0_d9ed_4106_8eb5_01cf0d2da7aa
initial amount: NaN
has only substance units: false
is: P36542
name: ATP5C1
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:509

http://identifiers.org/biomodels.db/MODEL1310110013#_0063ec7e_1d28_49aa_ae7f_c8105007adbe
name: _LOC728997_1_c
has only substance units: false
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:LOC728997
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM 4h2oglt m
is: CHEBI:17742
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: HMDB02070
initial amount: NaN
name: 4-hydroxy-2-oxoglutarate(2-)
has only substance units: false

metaM Rtotalcoa c
initial concentration: 1.0
is: HMDB01448
name: R total Coenzyme A
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
initial amount: NaN
constant: false
is: CHEBI:16189
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247

metaM ksii core2 l
name: keratan sulfate II (core 2-linked)
boundary condition: false
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: HMDB01644
is: CHEBI:17140

metaR LYStm
type: Reaction
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reversible: true
is: SBO:0000185
name: Lysine mitochondrial transport via ornithine carrier
product: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_16f2557f_1a31_4588_acb1_a341ae242122
type: Species
name: PDE5A
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8654
is: SBO:0000252
initial concentration: NaN
constant: false

metaR HEX1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.1
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: hexokinase (D-glucose:ATP)
fast: false
product: MODEL1310110013#
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110013#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_750bc799_6dd0_452d_9df6_ef0ad835a471
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: Q96BD0
is: SBO:0000252
name: SLCO4A1
is encoded by: hsa:28231
initial concentration: NaN

metaR GLCtly
is: SBO:0000185
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: false
name: glucose efflux from lysosome

metaR FAOXC16DCr
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_417a0aea_5692_4cf2_8881_6e8e61a3afa7
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
is: SBO:0000297
is encoded by: hsa:9551
boundary condition: true
has part: F8W7V3
type: Species
initial concentration: NaN
is encoded by: hsa:517
has only substance units: false
constant: false
initial amount: NaN

metaM gpail hs c
initial concentration: 1.0
is: SBO:0000247
name: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
constant: false
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:17049
notes: FORMULA: C15H28NO13PFULLRCO2FULLR2CO2 CHARGE: 0 EHMN_ABBREVIATION: C04248
initial amount: NaN

metaM 1pipdn2c x
is: HMDB01084
constant: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:16187
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 1-piperideine-2-carboxylate

http://identifiers.org/biomodels.db/MODEL1310110013#_7008382c_0654_423f_8722_93749b131068
name: _AI640625_1_c
initial concentration: NaN
has only substance units: false
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI640625

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_59cd8f58_9976_4979_a930_66c1e38cef8e
is: O00337
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9154
boundary condition: true
name: SLC28A1
is: SBO:0000252
constant: false

metaR FAOXC183803m
type: Reaction
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:3, n-3 -> c8:0 - 5 rounds of beta ox, lose 3 degrees of unsat - only 2 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000000
fast: false

metaM 2ddecdicoa m
is: C05279
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB11123
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 2,6-dodecadienoylcoa
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_dd1c7d6b_9514_4c85_8b09_2874a75d3a25
is: Q9UPR5
is encoded by: hsa:6543
is: SBO:0000252
initial concentration: NaN
name: SLC8A2
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaM leuktrF4 c
constant: false
is: CHEBI:27491
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB06465
initial amount: NaN
name: leukotriene F4
is: SBO:0000247

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_86fae26d_fc1a_482d_8545_6cda56a7228a
boundary condition: true
type: Species
name: NT5M
constant: false
is: Q9NPB1
has only substance units: false
is encoded by: hsa:56953
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_edf9bc83_f8fd_4fa4_8284_27f10f1d277c
constant: false
is encoded by: hsa:56848
initial concentration: NaN
type: Species
is: Q9NRA0
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SPHK2

http://identifiers.org/biomodels.db/MODEL1310110013#_fa0c1932_4051_445a_b419_c4dc19a03708
is: Q53H96
is encoded by: hsa:65263
type: Species
name: PYCRL
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR VD3
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
name: Vitamin D3 formation
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_0cafd5ff_00ac_41c1_ba43_6641c888a17d
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: SLC2A9
type: Species
initial amount: NaN
is encoded by: hsa:56606
is: SBO:0000252

metaM pail4p hs c
constant: false
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
boundary condition: false
is: CHEBI:58178
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_68e9874f_dd98_40b6_b42c_cc049f5ef6a8
name: SDHA
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: P31040
has only substance units: false
type: Species
is encoded by: hsa:6389

metaR PIt7
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
type: Reaction
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
name: phosphate transport in/out via three Na+ symporter

http://identifiers.org/biomodels.db/MODEL1310110013#_139fa199_9e9d_4e8f_a920_88dfa7303624
is: Q14032
is encoded by: hsa:570
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: BAAT
has only substance units: false
constant: false

metaR LCTStg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
is: SBO:0000185
name: lactose transport from Golgi to extracellular (via vesicle)
fast: false
kinetic law: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_9cacdef1_9481_4a62_ad66_210b8cab765a
is encoded by: hsa:R14373
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
name: _R14373_1_x
is: SBO:0000252
initial amount: NaN

metaM elaid e
boundary condition: false
initial amount: NaN
is: CHEBI:30825
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
type: Species
is: HMDB00573
is: SBO:0000247
name: elaidate
has only substance units: false
initial concentration: 1.0

metaM leuktrF4 e
is: CHEBI:27491
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06465
has only substance units: false
name: leukotriene F4
constant: false
is: SBO:0000247

metaM L2aadp c
initial concentration: 1.0
boundary condition: false
constant: false
name: L-2-aminoadipate(1-)
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:58672
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: HMDB00510

metaM ksi deg1 l
is: HMDB00174
has only substance units: false
is: CHEBI:18287
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I, degradation product 1
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
constant: false
type: Species

metaR PHEyLATthc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Phenylalanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_a7a40945_3985_43f3_a85d_23e031dfc73a
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:AL048840
name: _AL048840_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR PROSTGE2t2
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
is described by: ECO:0000269
fast: false

metaR UDPtl
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
fast: false
name: udp intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction

metaM fmn c
is: CHEBI:58210
constant: false
boundary condition: false
type: Species
has only substance units: false
name: FMN
initial concentration: 1.0
is: C00061
initial amount: NaN
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: HMDB01520
is: SBO:0000247

metaM HC01231 m
constant: false
has only substance units: false
is: CHEBI:58480
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate

http://identifiers.org/biomodels.db/MODEL1310110013#_b7564cee_7326_415a_b7d5_26950ba37f98
has only substance units: false
type: Species
is: P56181
is: SBO:0000252
initial concentration: NaN
name: NDUFV3
is encoded by: hsa:4731
constant: false
initial amount: NaN
boundary condition: true

metaM lneldccrn c
is: HMDB06461
initial amount: NaN
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
initial concentration: 1.0
type: Species
name: Linoelaidyl carnitine
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247

metaR DOLMANP Lter
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
name: dolichol-phosphate mannose flippase (liver)
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_28794da0_c7a2_41f2_90b0_ea90a691f775
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:8527
boundary condition: true
has only substance units: false
is: SBO:0000252
name: DGKD
initial amount: NaN

metaM occoa c
type: Species
boundary condition: false
is: HMDB01070
initial amount: NaN
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
has only substance units: false
is: C01944
is: SBO:0000247
is: CHEBI:57386

metaR PYNP2r
kinetic law: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
product: MODEL1310110013#
name: pyrimidine-nucleoside phosphorylase (uracil)
reversible: true
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110013#

metaR PIt8
is described by: ECO:0000006
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
name: phosphate transport in/out via Na+ symporter

metaM elaid c
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
initial amount: NaN
is: CHEBI:30825
type: Species
constant: false
name: elaidate
is: HMDB00573
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR ARSA
fast: false
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
modifier: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.8
name: Arylsulfatase A

metaM stcoa c
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
boundary condition: false
is: CHEBI:57394
initial amount: NaN
name: Stearoyl-CoA (n-C18:0CoA)
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB01114
type: Species
is: C00412

metaR NACHEX9ly
fast: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110013#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000

metaR NDPK3m
kinetic law: MODEL1310110013#
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110013#
reactant: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM hs deg22 l
type: Species
boundary condition: false
is: CHEBI:21338
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02704
notes: FORMULA: C37H56NO35S CHARGE: -3
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247

metaM HC01231 c
name: N-[(R)-pantothenoyl]-L-cysteinate
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58480
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
constant: false

metaM 4mop m
type: Species
initial concentration: 1.0
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00695
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

metaR FAOXC123C102x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaR URIt5le
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: false
name: uridine transport in via sodium symport (1:2)
fast: false
type: Reaction
is described by: ECO:0000134
product: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#

metaR ACITL
product: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.3.8
name: ATP-Citrate lyase
reactant: MODEL1310110013#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD

metaR ADA
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Adenosine deaminase
modifier: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
kinetic law: MODEL1310110013#
reversible: false
is described by: ECO:0000269
product: MODEL1310110013#
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_187ba286_bea1_4c5a_8d20_4cd73d04cf39
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: CA5A
is: SBO:0000252
is: P35218
initial amount: NaN
is encoded by: hsa:763
boundary condition: true

metaM imp c
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00175
is: CHEBI:58053
constant: false
name: IMP
is: C00130
is: SBO:0000247
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130

metaR r1881
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110013#
fast: false
name: Y+LAT2 Utilized transport
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#

metaM 10fthf5glu e
type: Species
initial amount: NaN
name: 10-formyltetrahydrofolate-[Glu](5)
is: CHEBI:57454
notes: FORMULA: C40H45N11O19 CHARGE: -6
constant: false
is: HMDB00972
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaM 4nphsf e
initial amount: NaN
boundary condition: false
name: 4-Nitrophenyl sulfate
constant: false
type: Species
is: HMDB06492
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
is: CHEBI:35422
initial concentration: 1.0

metaM 11 cis retfa e
initial concentration: 1.0
is: SBO:0000247
is: HMDB00972
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:57454
name: fatty acid 11-cis-retinol
boundary condition: false
type: Species
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0

metaM hdcea r
initial amount: NaN
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species
name: palmitoleate
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:32372
is: HMDB03229

metaR FAOXC102C103m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR P45027A11m
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
is described by: ECO:0000269
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
fast: false
product: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 4 AUTHORS: NOTES:from uniprot NJ
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR r1298
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
fast: false
is: SBO:0000185
name: Vesicular transport
reactant: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_b5d6bbde_2604_497e_8324_ee47abc686da
constant: false
type: Species
is: Q8NFW8
name: CMAS
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55907
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_661d9eb8_539c_4ebc_b4b6_b1890af0d3ab
constant: false
type: Species
is: Q92819
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3037
name: HAS2

http://identifiers.org/biomodels.db/MODEL1310110013#_80cdcaa9_49a9_4ce6_bfd5_aebf8d8cbff6
is: SBO:0000252
name: _AI653169_1_c
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:AI653169
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_fbd6c23c_96d4_4620_9c7a_ac3d92f3d77b
constant: false
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
type: Species
name: _HG2846_HT2983_1_m
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM ksii core2 e
is: CHEBI:17268
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: keratan sulfate II (core 2-linked)
type: Species
constant: false
is: HMDB00211

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_531e98f5_d07c_4c3e_a995_e8d49e27e52c
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: HMGCS1
boundary condition: true
is encoded by: hsa:3157
initial concentration: NaN
is: Q01581

http://identifiers.org/biomodels.db/MODEL1310110013#_b4b00570_9ca0_42c4_a243_2dbc4779fb0f
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:10870
initial amount: NaN
name: HCST
constant: false
is: Q9UBK5
boundary condition: true

metaR PAPStg
is described by: ECO:0000269
is: SBO:0000185
name: 3'-Phosphoadenylyl sufate Golgi transport
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
kinetic law: MODEL1310110013#

metaR HEX7
name: hexokinase (D-fructose:ATP)
is: SBO:0000176
modifier: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
is described by: ECO:0000304
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.2
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_eb7f13bf_e291_4e95_89d4_67213e4e120c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: P42765
is encoded by: hsa:10449
name: ACAA2

metaM xyl D e
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
name: aldehydo-D-xylose
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: CHEBI:15936

metaR r1299
product: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
name: Vesicular transport
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR GAO2g
reactant: MODEL1310110013#
name: Ganglioside O-acetylation
fast: false
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
product: MODEL1310110013#
reversible: false
kinetic law: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110013#
type: Reaction

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR CO2tm
name: CO2 transport (diffusion), mitochondrial
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#

metaM paps c
is: SBO:0000247
is: HMDB01134
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:58339
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053

metaR ASPTAm
is: SBO:0000176
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: aspartate transaminase
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
reversible: true
fast: false
product: MODEL1310110013#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.6.1.1

http://identifiers.org/biomodels.db/MODEL1310110013#_f287f3c9_f83f_4dcd_a193_cac655cfdf50
is: SBO:0000252
boundary condition: true
name: UPP1
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7378
constant: false
type: Species
is: Q16831
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_1a3ca215_6d29_4a3d_b281_be796ddeaea0
initial concentration: NaN
name: ACAA1:HSD17B4:ACOX1
is: SBO:0000297
type: Species
has only substance units: false
constant: false
is encoded by: hsa:3295
initial amount: NaN
has part: E9PB82
boundary condition: true

metaR RBTt
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
reversible: false
name: ribitol transport via passive diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185

metaR r1722
modifier: MODEL1310110013#
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110013#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM HC01399 m
initial amount: NaN
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: CHEBI:27466
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110013#_58dde4f3_fde6_4d60_9e83_ef1ac61d2dcc
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:53
type: Species
name: ACP2
initial amount: NaN
is: SBO:0000252
is: E9PCI1
boundary condition: true

metaM bilglcur c
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
type: Species
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_e5e7ade1_6179_4a0e_b2c2_60f390cb5af4
initial concentration: NaN
is: B2RB13
type: Species
has only substance units: false
name: ACSL6
is: SBO:0000252
is encoded by: hsa:23305
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_e145b095_de34_40c1_8af8_9432bb81bca5
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: MCCC2
constant: false
is: Q9HCC0
is encoded by: hsa:64087

metaM lneldccrn m
has only substance units: false
name: Linoelaidyl carnitine
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
is: SBO:0000247
is: HMDB06461
type: Species
boundary condition: false
constant: false
initial amount: NaN

metaR HEX4
is described by: ECO:0000304
reactant: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
is: SBO:0000176
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
product: MODEL1310110013#
reversible: false
name: hexokinase (D-mannose:ATP)

http://identifiers.org/biomodels.db/MODEL1310110013#_070f9f3d_15ef_4dde_a05e_d39bd33e1ff3
is encoded by: hsa:8818
initial concentration: NaN
boundary condition: true
name: DPM2
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM xyl D c
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:15936
constant: false
boundary condition: false
name: aldehydo-D-xylose
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_fac08e1f_bf90_4230_8eb2_d1da224ada90
has only substance units: false
boundary condition: true
is encoded by: hsa:270
initial amount: NaN
is: P23109
initial concentration: NaN
name: AMPD1
constant: false
is: SBO:0000252
type: Species

metaM 34hpp c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: HMDB00707
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:36242

metaR KSII CORE4tly
type: Reaction
is: SBO:0000185
product: MODEL1310110013#
name: keratan sulfate II (core 4) transport, extracellular to lysosome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110013#
reversible: false
fast: false
kinetic law: MODEL1310110013#

metaM 34hpp e
is: HMDB00707
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36242
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate

metaM glu L m
has only substance units: false
boundary condition: false
name: L-glutamate(1-)
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
initial concentration: 1.0
constant: false
is: HMDB00148
is: SBO:0000247
is: CHEBI:29985
initial amount: NaN

metaM pristcoa c
has only substance units: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
name: pristanoyl coa
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:51341

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaR r1728
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#

metaM stcoa m
is: CHEBI:57394
boundary condition: false
name: Stearoyl-CoA (n-C18:0CoA)
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
has only substance units: false
type: Species
is: HMDB01114
is: C00412
constant: false
initial amount: NaN

metaR CHOLESTle
is version of: http://identifiers.org/ec-code/3.1.1.13
kinetic law: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
type: Reaction
name: hydrolysis of cholesterol ester by cholesterol esterase
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110013#
reversible: false
is described by: ECO:0000134

metaM bilglcur e
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
boundary condition: false
type: Species
is: CHEBI:57767
name: mono(glucosyluronic acid)bilirubin(2-)
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_5aaf7009_a524_4206_9213_d46ae69fa1a2
name: COX7A2L
boundary condition: true
is encoded by: hsa:9167
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: Q6FGA0

metaM xoltriol m
is: CHEBI:16496
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01457
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
has only substance units: false
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_7c86a8fd_d35f_4413_adf0_8c9d7c121333
constant: false
initial amount: NaN
name: DBT
has only substance units: false
initial concentration: NaN
is: P11182
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:1629

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR CO2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
name: CO2 peroxisomal transport
reversible: true
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
product: MODEL1310110013#
reactant: MODEL1310110013#

metaR C40CPT1
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM 4nphsf c
constant: false
name: 4-Nitrophenyl sulfate
is: SBO:0000247
type: Species
is: HMDB06492
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
initial concentration: 1.0
has only substance units: false
is: CHEBI:35422

http://identifiers.org/biomodels.db/MODEL1310110013#_c45b9597_5cc3_44ae_9387_aacdbd9f0503
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
has part: Q9NY65
name: EHHADH:ACAA1:ACOX1
is encoded by: hsa:1962
type: Species
initial amount: NaN
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110013#_0b57fa4a_27e5_4bdc_9216_43b92c418c77
has only substance units: false
is: SBO:0000252
type: Species
is: P24752
constant: false
is encoded by: hsa:38
name: ACAT1
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM imp e
has only substance units: false
is: HMDB00175
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial concentration: 1.0
boundary condition: false
is: CHEBI:58053
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
name: IMP(2-)

metaR r0345
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000000
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reversible: true
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.13

metaM 3dodtricoa m
constant: false
has only substance units: false
is: SBO:0000247
is: C05279
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 3,6,9-dodecatrienoylcoa
is: HMDB11123
type: Species

metaR PPD2CSPp
reversible: false
reactant: MODEL1310110013#
name: PPD2CSPp
product: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
fast: false

metaR r1726
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
modifier: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
name: Y+LAT2 Utilized transport

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaM ksi deg6 l
is: CHEBI:12936
is: SBO:0000247
is: HMDB00143
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
initial amount: NaN
name: keratan sulfate I, degradation product 6
constant: false
type: Species

metaM eicostetcoa m
name: eicosatetranoyl coenzyme A
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: C16164
constant: false
is: SBO:0000247

metaM L2aadp m
type: Species
name: L-2-aminoadipate(1-)
has only substance units: false
is: HMDB00510
initial amount: NaN
is: CHEBI:58672
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

http://identifiers.org/biomodels.db/MODEL1310110013#_2ea53124_25a1_4a56_9805_456bc46fe7f8
is: B3KVI7
boundary condition: true
name: IVD
initial concentration: NaN
is encoded by: hsa:3712
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaR r1019
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false

metaR ACGAMK
name: N-acetylglucosamine kinase
type: Reaction
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.59
is described by: ECO:0000269
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_b6e0ccc3_a108_4a2a_92ae_a031cc364833
is: SBO:0000252
name: ASRGL1
initial concentration: NaN
type: Species
is: Q7L266
constant: false
initial amount: NaN
is encoded by: hsa:80150
boundary condition: true
has only substance units: false

metaR XOLDIOLONEt
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110013#
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110013#

metaM asn L m
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: CHEBI:17196
boundary condition: false
is: HMDB00168
type: Species
initial concentration: 1.0
name: L-asparagine
is: SBO:0000247

metaR ASNPHELAT2tc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Asparagine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR BILIRUBt2
kinetic law: MODEL1310110013#
name: bilirubin transport via bicarbonate countertransport
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
modifier: MODEL1310110013#
is: SBO:0000185
product: MODEL1310110013#
fast: false
is described by: ECO:0000269
reversible: true

metaR CHOLtn
type: Reaction
is described by: ECO:0000000
name: Choline transport, nuclear through pores
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it

metaR BALAtmr
product: MODEL1310110013#
name: Beta-alanine reversible mitochondrial transport (diffusion)
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110013#
is: SBO:0000185
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_701bbeec_9bc1_4b6a_bf98_24249c6a8826
initial concentration: NaN
is: P06132
type: Species
initial amount: NaN
is encoded by: hsa:7389
name: UROD
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaR r1018
name: Transport reaction
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185
reversible: true

metaM nrpphr e
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
boundary condition: false
type: Species
initial amount: NaN
name: Norepinephrine
is: CHEBI:33569
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00216

metaR GBA
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.45
reactant: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110013#
name: Glucosylceramidase
type: Reaction
fast: false
kinetic law: MODEL1310110013#

metaM s2l2n2m2masn e
initial concentration: 1.0
name: de-Fuc form of PA6
type: Species
is: CHEBI:3554
has only substance units: false
boundary condition: false
is: C00255
is: HMDB00244
initial amount: NaN
constant: false
notes: FORMULA: C84H135N6O61X CHARGE: -2
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_00a35128_db2f_4db2_bcf4_f824d0bbc46a
is: SBO:0000252
name: NDUFA10
constant: false
initial concentration: NaN
is: O95299
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:4705

metaM hista c
is: HMDB00870
name: histamium
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:58432

http://identifiers.org/biomodels.db/MODEL1310110013#_9f5bf0ef_8b4d_4087_aae2_6474bd1b5b2d
is encoded by: hsa:8897
has only substance units: false
boundary condition: true
type: Species
name: MTMR3
is: SBO:0000252
is: Q13615
initial concentration: NaN
initial amount: NaN
constant: false

metaR CERT1rt
is described by: ECO:0000304
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
name: ceramide transport protein

metaM 4abutn m
boundary condition: false
name: 4-ammoniobutanal
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
is: HMDB01080
type: Species
has only substance units: false

metaR DPCOAK
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.3
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110013#
product: MODEL1310110013#
fast: false
name: dephospho-CoA kinase

http://identifiers.org/biomodels.db/MODEL1310110013#_f2ce5c37_3901_46e1_bc0a_f256d0e34854
is: Q9UHI5
name: SLC7A8
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:23428
initial concentration: NaN

metaR UMPK4n
name: UMP kinase (GTP),nuclear
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
type: Reaction
product: MODEL1310110013#

metaR TYMSFt
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reversible: false
fast: false
name: Tyramine O-sulfate transport (diffusion)
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
is described by: ECO:0000000

metaM 3decdicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 3,7-decadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110013#_fa819c32_64c4_41bc_8e31_1d37e2221fc9
constant: false
name: DGUOK
boundary condition: true
is encoded by: hsa:1716
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM 3hexdtricoa x
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
name: 3,7,10-hexadecatrienoylcoa

metaM tymsf e
boundary condition: false
is: HMDB06409
is: SBO:0000247
constant: false
has only substance units: false
name: Tyramine O-sulfate
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)

http://identifiers.org/biomodels.db/MODEL1310110013#_9a1fb00b_64d4_4fde_8a8c_5c61d66e27c1
boundary condition: true
is: P08237
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5213
constant: false
initial amount: NaN
name: PFKM
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_020c993a_eb29_446b_bd73_0828f9018043
has only substance units: false
name: ALDH2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:217
is: P05091
initial amount: NaN
type: Species
constant: false

metaM nrpphr c
constant: false
is: HMDB00216
boundary condition: false
name: Norepinephrine
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:33569
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547

metaR EICOSTETCRNt
type: Reaction
is described by: ECO:0000000
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#

metaM arachdcrn r
constant: false
initial concentration: 1.0
name: C20:4 carnitine
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06523
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: CHEBI:57368

metaR 5OXPROt
name: Transport of 5-oxoprolinate
reactant: MODEL1310110013#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_16cae2d1_b2ef_4d5b_ab5a_f7a6c0ef36b4
boundary condition: true
initial amount: NaN
is: C9JFZ1
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:8867
name: SYNJ1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_dc890503_527f_4470_a985_dec4d1e0345f
name: ACAA2
constant: false
is encoded by: hsa:10449
type: Species
is: SBO:0000252
initial amount: NaN
is: P42765
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR PFK26
reactant: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
name: 6-phosphofructo-2-kinase
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.105
type: Reaction
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110013#

metaM hista e
has only substance units: false
name: histamium
is: HMDB00870
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
initial concentration: 1.0

metaM kynate c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
type: Species
constant: false
is: SBO:0000247
is: HMDB00715
name: kynurenate
is: CHEBI:58454
boundary condition: false
initial amount: NaN

metaM dadp n
has only substance units: false
constant: false
is: CHEBI:57667
boundary condition: false
initial concentration: 1.0
name: dADP(3-)
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01508

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR ILETAm
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
is described by: ECO:0000269
fast: false
product: MODEL1310110013#
type: Reaction
name: isoleucine transaminase, mitochondrial
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR BPNT
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
name: 3',5'-bisphosphate nucleotidase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.7
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110013#

metaR OCDCAtr
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
reactant: MODEL1310110013#
is described by: ECO:0000000
reversible: true
product: MODEL1310110013#
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110013#_ac3f6f47_75ac_4a06_b350_9e9270796f18
is encoded by: hsa:1633
is: P27707
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: DCK
boundary condition: true

metaM dudp m
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
name: dUDP(3-)
type: Species
is: SBO:0000247
is: CHEBI:60471
initial amount: NaN
has only substance units: false
is: HMDB01000
constant: false
boundary condition: false

metaM tymsf c
name: Tyramine O-sulfate
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
initial amount: NaN
is: HMDB06409
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4fb3016e_8ae2_4c90_a73c_3a0951d65178
is: SBO:0000252
is encoded by: hsa:5281
has only substance units: false
type: Species
initial amount: NaN
name: PIGF
initial concentration: NaN
boundary condition: true
is: Q6IB04
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_3ba2e707_418f_4509_8335_7809e8b80735
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _AI091231_1_c
initial amount: NaN
is encoded by: hsa:AI091231
constant: false
type: Species
initial concentration: NaN

metaM dadp m
is: CHEBI:57667
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: dADP(3-)
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
is: HMDB01508
constant: false

metaM thf m
boundary condition: false
initial amount: NaN
is: HMDB01846
is: SBO:0000247
type: Species
is: CHEBI:57453
initial concentration: 1.0
name: 5,6,7,8-Tetrahydrofolate
is: C00101
constant: false
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

metaR r2534
reactant: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_4e074f9f_0bd3_47d7_b64e_ae7d1720f1b2
boundary condition: true
is encoded by: hsa:229
constant: false
has only substance units: false
is: SBO:0000252
is: P05062
name: ALDOB
initial concentration: NaN
initial amount: NaN
type: Species

metaR RBK
modifier: MODEL1310110013#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: ribokinase
is version of: http://identifiers.org/ec-code/2.7.1.15
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000304
product: MODEL1310110013#
type: Reaction
reversible: false

metaR RTOTAL3t
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL3 transport
product: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM HC01415 m
is: CHEBI:27537
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: (2E)-Octenoyl-CoA
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276

metaR r1167
product: MODEL1310110013#
type: Reaction
is: SBO:0000176
reversible: false
name: EC:2.3.1.26
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:

metaR FAOXC101C8x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaM fucacgalfucgalacglcgalgluside hs g
is: HMDB01354
is: CHEBI:57455
has only substance units: false
is: SBO:0000247
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1
initial concentration: 1.0
notes: FORMULA: C64H112N3O35FULLRCO CHARGE: 0
is: C00445
initial amount: NaN
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_fa122ab4_7fcd_4240_a2e2_457cfc5e223e
is: SBO:0000252
constant: false
is encoded by: hsa:9374
boundary condition: true
is: Q9UMR5
initial amount: NaN
initial concentration: NaN
name: PPT2
has only substance units: false
type: Species

metaM arachdcrn x
is: CHEBI:57368
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: HMDB06523
initial concentration: 1.0
constant: false
name: C20:4 carnitine
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR r0739
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
is: SBO:0000176
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_72728ddf_3aea_40cb_83df_edab6cf2831c
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:23530
constant: false
name: NNT

metaM anth c
is: HMDB01123
name: anthranilate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16567
has only substance units: false
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108

http://identifiers.org/biomodels.db/MODEL1310110013#_d8828c37_bd0d_42db_ae28_4362bf284084
type: Species
is: Q6P1K9
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80025
name: PANK2
initial concentration: NaN
has only substance units: false

metaR CYTK6n
kinetic law: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
name: cytidylate kinase (CMP,CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110013#
fast: false
is: SBO:0000176
reversible: true

metaR r0062
fast: false
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.17
name: Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1
type: Reaction
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reversible: false
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_3bb62ee5_cb0d_4ba3_91d0_6ed488803d81
name: SLC22A5
initial amount: NaN
type: Species
is: O76082
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6584
constant: false
has only substance units: false
is: SBO:0000252

metaR TTDCAtr
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: tetradecanoate (transport)
reversible: true
type: Reaction

metaM dec24dicoa x
initial concentration: 1.0
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,4-decadienoylcoa
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01168
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_b1d3d4b2_9498_4c02_b42c_d62bff26b3db
is: SBO:0000252
boundary condition: true
name: INPP5B
type: Species
is: P32019
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:3633
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_33031ae1_433a_4f07_bdbb_c36210eb3412
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI373818
boundary condition: true
is: SBO:0000252
name: _AI373818_1_m
initial concentration: NaN
constant: false

metaM fru e
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
constant: false
is: HMDB00660
is: CHEBI:15824
type: Species
is: C00095
boundary condition: false
initial concentration: 1.0
name: D-Fructose

http://identifiers.org/biomodels.db/MODEL1310110013#_f90d8e9f_7ed2_4b0c_b4e7_fff43c3a199d
initial amount: NaN
is encoded by: hsa:6448
is: P51688
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: SGSH

metaR r2532
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000000

metaM cdpdag hs m
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
name: CDP-diacylglycerol(2-)
is: CHEBI:58332
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_bddf8a3b_93e0_4ee8_a771_de959a112dc6
is: SBO:0000252
boundary condition: true
type: Species
is: P09917
initial amount: NaN
name: ALOX5
is encoded by: hsa:240
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_563e5cc6_ebb3_4752_91f7_086e3914135c
is encoded by: hsa:6482
is: SBO:0000252
name: ST3GAL1
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_e1d059cb_9ad9_46cc_9889_126feffa49c9
name: PDE1A
is encoded by: hsa:5136
boundary condition: true
type: Species
is: Q9Y633
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaM CE2420 m
has only substance units: false
is: HMDB11123
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:28387
initial concentration: 1.0
is: SBO:0000247
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
constant: false

metaM anth e
type: Species
name: anthranilate
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16567
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB01123
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1

metaM asn L e
is: HMDB00168
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:17196
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: SBO:0000247
name: L-asparagine

metaR THYOXt
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: T4 transport via bicarbonate countertransport
fast: false
modifier: MODEL1310110013#
product: MODEL1310110013#

metaM s2l2n2m2masn l
boundary condition: false
type: Species
has only substance units: false
is: HMDB00174
name: de-Fuc form of PA6
is: SBO:0000247
notes: FORMULA: C84H135N6O61X CHARGE: -2
constant: false
is: CHEBI:18287
initial concentration: 1.0
initial amount: NaN

metaR CHOLtu
modifier: MODEL1310110013#
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110013#
type: Reaction
name: Choline uniport
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
reactant: MODEL1310110013#
is: SBO:0000185

metaR BMTer L
is: SBO:0000176
product: MODEL1310110013#
name: B mannosyltransferase, endoplasmic reticulum
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110013#
reversible: false

metaR CGLYt3 2
fast: false
name: Cys-Gly transport in via proton symport
product: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
is described by: ECO:0000304
reversible: false
is: SBO:0000185
type: Reaction

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM man1p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: CHEBI:35374
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: HMDB06330
type: Species
initial concentration: 1.0
boundary condition: false
name: D-Mannose 1-phosphate

metaR r1010
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Postulated transport reaction
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaR S2TASE1ly
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.13
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
fast: false
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
name: iduronate-2-sulfatase, lysosomal
type: Reaction
is: SBO:0000176

metaM fru c
has only substance units: false
name: D-Fructose
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
type: Species
is: SBO:0000247
is: CHEBI:15824
initial concentration: 1.0
is: C00095
boundary condition: false
initial amount: NaN

metaR CERT2gt
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: true
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is: SBO:0000185
modifier: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_098330bf_638d_4dd8_8ff3_e9ebd5d69c29
is: P54803
name: GALC
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:2581

metaM 4nph e
name: 4-nitrophenolate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB01232
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
constant: false
has only substance units: false
is: CHEBI:57917

metaR r0629
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.4.1
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
product: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.22
modifier: MODEL1310110013#

metaR GSNt
name: guanosine facilated transport in cytosol
kinetic law: MODEL1310110013#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
fast: false
reactant: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110013#_844b7348_07f7_49f5_bcce_07393f99399c
constant: false
initial concentration: NaN
name: UGT1A8
has only substance units: false
is: Q5DSZ6
boundary condition: true
is encoded by: hsa:54576
initial amount: NaN
is: SBO:0000252
type: Species

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaM 4abutn e
boundary condition: false
is: CHEBI:58264
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01080
name: 4-ammoniobutanal
initial concentration: 1.0
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial amount: NaN
constant: false

metaM asn L c
initial concentration: 1.0
is: HMDB00168
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
is: CHEBI:17196
constant: false
initial amount: NaN
is: SBO:0000247

metaM hs deg15 l
is: HMDB00127
has only substance units: false
constant: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15748
name: heparan sulfate, degradation product 15
type: Species

metaR r0840
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
type: Reaction
name: Free diffusion
is version of: http://identifiers.org/ec-code/1.14.13.70
is: SBO:0000185
modifier: MODEL1310110013#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_f217dc4e_e420_4287_ba36_a1997070554c
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: INPP5J
is encoded by: hsa:27124
type: Species
is: Q15735

metaM dec24dicoa m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
name: 2,4-decadienoylcoa
initial concentration: 1.0
is: HMDB01168
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_f0f22172_96ce_4e73_85de_6c30baf77b12
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: _AI971036_1_m
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI971036

metaM 3mop m
has only substance units: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
boundary condition: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:28654
is: HMDB00491

metaM xu1p D c
is: HMDB06534
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
constant: false
initial concentration: 1.0
is: SBO:0000247
name: D-Xylulose 1-phosphate
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_5a3b1ede_b2b8_48b0_8e3e_8b1c01fa3d9e
name: GALK2
is: SBO:0000252
is: Q01415
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2585
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_ea80304b_9319_47c8_804b_bf0638d3867a
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI291895_1_c
initial concentration: NaN
constant: false
is encoded by: hsa:AI291895

http://identifiers.org/biomodels.db/MODEL1310110013#_1780c88c_4512_4cf9_8302_f274a3765a7e
initial amount: NaN
boundary condition: true
is encoded by: hsa:2879
is: P36969
constant: false
is: SBO:0000252
name: GPX4
initial concentration: NaN
has only substance units: false
type: Species

metaR DTMPK
is version of: http://identifiers.org/ec-code/2.7.4.9
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000269
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110013#
name: dTMP kinase
fast: false
is: SBO:0000176

metaR GGH 6THFe
product: MODEL1310110013#
fast: false
name: Gamma-glutamyl hydrolase (6THF), extracellular
reactant: MODEL1310110013#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110013#
type: Reaction

metaR 5MTHFt2le
reversible: true
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: 5-methyltetrahydrofolate transport via anion exchange

metaR r0841
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.1.1.271
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110013#
name: Free diffusion

metaR G5SDym
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
reversible: false
is described by: ECO:0000254
name: glutamate-5-semialdehyde dehydrogenase (m)
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.1.41
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_7cb5d95c_e176_4efb_91a1_eae5180565a9
initial concentration: NaN
is: D9HTE9
boundary condition: true
name: SLC25A1
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:6576

metaR RE1522M
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1522
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110013#
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_3a4542a2_bd68_4137_a050_b0ae867a16dc
initial concentration: NaN
is: O95139
type: Species
is encoded by: hsa:4712
constant: false
is: SBO:0000252
name: NDUFB6
has only substance units: false
boundary condition: true
initial amount: NaN

metaR NADHtpu
type: Reaction
is: SBO:0000185
name: NADH transporter, peroxisome
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reversible: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_36c529e4_3a88_49c6_a313_edf209910fe3
is encoded by: hsa:AI539321
type: Species
constant: false
name: _AI539321_1_c
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM 4ppan c
is: SBO:0000247
name: D-4'-Phosphopantothenate
is: CHEBI:10986
has only substance units: false
is: C03492
initial amount: NaN
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: HMDB01016
initial concentration: 1.0
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_8cfe88e7_1508_4ee3_a4b0_0ab3b6281820
is encoded by: hsa:3155
boundary condition: true
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: HMGCL
is: Q6IBC0

http://identifiers.org/biomodels.db/MODEL1310110013#_19d4f83d_52b0_42c1_82e1_cbbea74b1c59
is: Q92911
has only substance units: false
boundary condition: true
is encoded by: hsa:6528
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC5A5
initial concentration: NaN

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_ce5361aa_a3a4_4d47_8eae_4ed126473fbb
initial amount: NaN
is encoded by: hsa:4048
is: P09960
name: LTA4H
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaM trdox m
is: CHEBI:18191
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: Oxidized thioredoxin
type: Species
initial amount: NaN
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343

metaM andrstandn r
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
name: 5alpha-androstane-3,17-dione
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:15994
type: Species
constant: false
is: HMDB00899
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_46b6ef97_eb74_403f_9a2b_b5d6b3b36ba7
is encoded by: hsa:366
initial concentration: NaN
is: O43315
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
name: AQP9
initial amount: NaN
type: Species

metaR r1435
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Transport reaction
reversible: false
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#

metaR ACHEe
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.7
type: Reaction
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false
product: MODEL1310110013#
name: Acetylcholinesterase

metaR r0842
modifier: MODEL1310110013#
product: MODEL1310110013#
name: Postulated transport reaction
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
fast: false
kinetic law: MODEL1310110013#

metaR PROSTGF2t
reactant: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
name: prostaglandin uniport
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110013#_192ed6d6_ea0b_45b1_9fdc_1401b82ad3cb
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: AADAT
is encoded by: hsa:51166
is: Q4W5N8

http://identifiers.org/biomodels.db/MODEL1310110013#_2fdc6cb5_6446_42f2_891f_c24b26b8e5e1
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P09417
type: Species
is: SBO:0000252
name: QDPR
has only substance units: false
is encoded by: hsa:5860

http://identifiers.org/biomodels.db/MODEL1310110013#_f733d93a_5921_40fe_8b7e_024a540358a2
is: SBO:0000252
initial amount: NaN
name: TXNRD1
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7296

metaR CYTDK2m
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110013#
name: cytidine kinase (ATP), mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110013#
fast: false
reversible: false

metaR EX hcoumarin LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hydroxy coumarin exchange
type: Reaction

metaM prostgi2 c
initial amount: NaN
initial concentration: 1.0
name: prostaglandin I2(1-)
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false
is: HMDB01335
is: CHEBI:57403
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_fddf3da5_6ea0_4d21_80a1_2d98a3fc9961
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q96QG2
name: SLC8A3
is encoded by: hsa:6547
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR GLYSARCNc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaR GCHOLAte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110013#
name: bile acid intracellular transport
type: Reaction
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_fd768b22_ca51_4ec1_8e9f_e88a6e03c388
is: B4DNK4
has only substance units: false
boundary condition: true
name: PKM2
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5315
type: Species
is: SBO:0000252

metaM arachdcrn m
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
type: Species
initial concentration: 1.0
is: HMDB01322
name: C20:4 carnitine
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57387

metaM n2m2nmn l
constant: false
is: CHEBI:16680
is: SBO:0000247
boundary condition: false
is: HMDB00939
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
notes: FORMULA: C50H84N4O36 CHARGE: 0

metaR GULNter
fast: false
is: SBO:0000185
name: L-gulonate endoplasmic reticular export
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#

metaR TETPENT6COAtx
kinetic law: MODEL1310110013#
fast: false
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110013#
reversible: true
type: Reaction

metaM dlnlcgcoa c
has only substance units: false
is: SBO:0000247
name: dihomo-gamma-linolenyl coenzyme A
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
initial amount: NaN
type: Species
is: CHEBI:27979

metaM nadp c
name: Nicotinamide adenine dinucleotide phosphate
is: SBO:0000247
is: C00006
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00217
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_90b00b0b_cf9d_489a_a969_530f78f94fa9
has only substance units: false
is: SBO:0000252
is: D3DX95
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1103
name: CHAT
initial amount: NaN

metaM ksi deg16 l
name: keratan sulfate I, degradation product 16
is: HMDB01354
has only substance units: false
constant: false
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
initial concentration: 1.0
is: CHEBI:57455
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR GBAl
reversible: false
name: Glucosylceramidase
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.45
modifier: MODEL1310110013#

metaM h2o x
constant: false
initial amount: NaN
name: H2O
type: Species
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: C00001
is: CHEBI:15377
boundary condition: false
has only substance units: false
is: HMDB02111
initial concentration: 1.0

metaR GLCt1r
reversible: true
name: glucose transport (uniport)
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000269
product: MODEL1310110013#
type: Reaction
fast: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_ab088a68_6e4f_4c64_8b71_2f5f4b22a2fc
constant: false
is encoded by: hsa:10400
boundary condition: true
initial amount: NaN
is: Q9UBM1
is: SBO:0000252
name: PEMT
initial concentration: NaN
has only substance units: false
type: Species

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM 4nph c
constant: false
is: CHEBI:57917
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01232
has only substance units: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
name: 4-nitrophenolate
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_59b0c91e_1f9a_4d32_b4f9_8cc91f2c2fde
name: NDUFA13
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is: Q9P0J0
is encoded by: hsa:51079
has only substance units: false
constant: false

metaM prostgi2 e
is: SBO:0000247
initial concentration: 1.0
name: prostaglandin I2(1-)
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
has only substance units: false
constant: false
is: CHEBI:57403
initial amount: NaN
type: Species
boundary condition: false

metaR EX gum LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for guar gums
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_c21821ad_d5dd_44fd_a2d4_c69091783a01
name: _H77542_1_r
is encoded by: hsa:H77542
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM leuktrE4 e
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial amount: NaN
constant: false
is: CHEBI:57462
is: SBO:0000247
boundary condition: false
name: leukotriene E4(1-)
is: HMDB02200

metaM HC00361 c
initial amount: NaN
is: CHEBI:58335
name: sedoheptulose 1,7-bisphosphate(4-)
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
type: Species

metaR ADK1m
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
name: adenylate kinase, mitochondrial
fast: false
reactant: MODEL1310110013#

metaR r2128
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

metaR r0504
fast: false
modifier: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.10
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
kinetic law: MODEL1310110013#
is: SBO:0000176
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reactant: MODEL1310110013#
reversible: true
product: MODEL1310110013#

metaR DESAT22 1p
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
is described by: ECO:0000000
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_09844c93_55e2_4fbb_a094_ab3bbf9392c1
is: O60331
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: PIP5K1C
boundary condition: true
is encoded by: hsa:23396

metaR R group phosphotase 1
is described by: ECO:0000000
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false
kinetic law: MODEL1310110013#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: R group phosphotase 1

metaM HC02187 e
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: reverse-triiodthyronine
type: Species
initial concentration: 1.0
has only substance units: false

metaM acald m
boundary condition: false
is: HMDB00990
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: acetaldehyde
is: CHEBI:15343
initial concentration: 1.0

metaR 5ADTSTSTERONESte
reactant: MODEL1310110013#
product: MODEL1310110013#
name: sulfonated testosterone transport
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM q10 e
is: CHEBI:46245
constant: false
is: SBO:0000247
is: HMDB01072
initial amount: NaN
has only substance units: false
name: ubiquinone-10
initial concentration: 1.0
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false

metaM uacgam c
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:57705
initial concentration: 1.0
has only substance units: false
is: HMDB00290
boundary condition: false
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
constant: false

metaR FBA
is: SBO:0000176
name: fructose-bisphosphate aldolase
modifier: MODEL1310110013#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
product: MODEL1310110013#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_5b35ae9e_7765_4a2c_ac6f_00b36515f112
boundary condition: true
constant: false
type: Species
name: DGUOK
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: E5KSL6
is encoded by: hsa:1716

metaR DCYTt
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
name: deoxycytidine transport via diffusion
reactant: MODEL1310110013#
is described by: ECO:0000000
type: Reaction

metaR r2127
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110013#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_cfab6040_5bb3_4033_bd19_dc7a2474d1dd
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:271
constant: false
is: Q01433
name: AMPD2
initial amount: NaN
has only substance units: false

metaM malcoa r
type: Species
constant: false
boundary condition: false
name: malonyl-CoA(4-)
has only substance units: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: CHEBI:57384
is: HMDB01175
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM ser L e
name: L-serine
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
is: HMDB00187

metaR ST8SIA11
reactant: MODEL1310110013#
fast: false
type: Reaction
product: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase
is version of: http://identifiers.org/ec-code/2.4.99.8

http://identifiers.org/biomodels.db/MODEL1310110013#_b885db4c_0fa3_42f0_9e1c_e3bbe772e65d
has only substance units: false
name: RHAG
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:6005
is: Q96E98
constant: false
initial concentration: NaN
is: SBO:0000252

metaR HGNTOR
is described by: ECO:0000269
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.13.11.5
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110013#
reactant: MODEL1310110013#

metaR 2OXOADPTm
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is described by: ECO:0000269
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110013#
name: 2-oxoadipate shuttle (cytosol/mitochondria)
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_82dd917e_ecfb_4bd5_b9fa_446cafbea64b
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q4KWH8
type: Species
is encoded by: hsa:23007
constant: false
initial amount: NaN
name: PLCH1
is: SBO:0000252

metaR FUCASE2ly
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.51
name: alpha-fucosidase, lysosomal
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110013#
reversible: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
fast: false

metaR r2129
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR SUCOASm
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
fast: false
name: Succinate--CoA ligase (ADP-forming)
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
product: MODEL1310110013#
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#

metaR ST8SIA12
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.8
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ

metaR XOLEST2te
fast: false
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
name: cholesterol ester transporter
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:
kinetic law: MODEL1310110013#
is described by: ECO:0000000

metaR PIK3
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.153
modifier: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.137
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.154
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaR IDOAASE2ly
name: alpha-L-iduronidase, lysosomal
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.76
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is: SBO:0000176
product: MODEL1310110013#

metaR DOLPMT3 Ler
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.4.1.260
modifier: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)

metaR r1590
product: MODEL1310110013#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#

metaM ser L c
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: SBO:0000247
is: CHEBI:17115
name: L-serine
is: HMDB00187

http://identifiers.org/biomodels.db/MODEL1310110013#_5dd6b71d_c1b0_43c6_af27_401f50e2596c
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: HSD17B10
is encoded by: hsa:3028
has only substance units: false
is: Q99714
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_14a51390_047e_4b5c_89a7_4842274a3d44
is encoded by: hsa:55350
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: VNN3
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4a634295_7bd3_4248_aaca_de8aac041f61
name: ACSS1
is: Q9NUB1
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:84532
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM c14dccoa x
initial amount: NaN
name: tetradecanedioylcoa
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C35H55N7O19P3S CHARGE: -5
is: SBO:0000247
boundary condition: false
is: HMDB02288
has only substance units: false

metaR FAOXC204C184m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaM 3decdicoa x
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
has only substance units: false
name: 3,7-decadienoylcoa
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR PSDm hs
name: Phosphatidylserine decarboxylase
reversible: false
product: MODEL1310110013#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.65
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269

metaR r1591
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM hs deg24 l
initial concentration: 1.0
is: HMDB00127
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:15748
name: GlcNAc-GlcA-(Gal)2-Xyl
notes: FORMULA: C31H50NO26 CHARGE: -1
type: Species

metaM dgchol x
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:36252
name: glycochenodeoxycholate
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_ae23942b_7d4c_4907_878c_458ccab217a4
is: SBO:0000252
initial concentration: NaN
type: Species
name: B3GALNT1
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: Q49AT3
is encoded by: hsa:8706

http://identifiers.org/biomodels.db/MODEL1310110013#_310633d9_6755_406f_a0af_bcf032d7472b
is encoded by: hsa:642502
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: _642502_1_c
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7e333851_d8c2_4b92_824d_eb92478e2ee6
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: P11182
is: SBO:0000252
constant: false
is encoded by: hsa:1629
boundary condition: true
type: Species
name: DBT

metaR PECDCHe
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_a7decd90_e2fc_4de5_8154_220a8967e672
is encoded by: hsa:26289
boundary condition: true
is: Q9Y6K8
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: AK5
constant: false
is: SBO:0000252

metaR RE0583C
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
type: Reaction
name: RE0583
fast: false
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_c7dff1e1_8a08_474a_a49c_e18c1cc76bcf
boundary condition: true
type: Species
has only substance units: false
is: Q6IB80
name: NDUFB3
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4709
is: SBO:0000252

metaR r1592
reversible: true
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_149d16fc_2a64_47f7_b8ef_81ad52f11c31
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:8876
type: Species
name: VNN1
is: O95497

metaR r0502
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.113
reactant: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
modifier: MODEL1310110013#

metaR r0627
product: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110013#
fast: false
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_1b339da6_ae7c_4d7f_95f2_411de4d86e58
initial concentration: NaN
is: Q3I5F7
constant: false
name: ACOT6
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:641372
is: SBO:0000252

metaR P450SCC1m
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
reactant: MODEL1310110013#
reversible: true
name: cholesterol monooxygenase
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110013#_130ed256_3194_4067_be33_5a86f843ee33
initial concentration: NaN
name: PDE9A
type: Species
initial amount: NaN
is encoded by: hsa:5152
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_c1d2ab76_330c_41c8_9739_0a7be5a43f90
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:205
constant: false
name: AK4
initial amount: NaN
is: SBO:0000252

metaM n2m2nm l
name: n2m2nmasn (w/o peptide linkage)
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30825
notes: FORMULA: C58H97N5O41 CHARGE: 0
is: HMDB00573

http://identifiers.org/biomodels.db/MODEL1310110013#_509d5c2b_a554_4b71_b8d8_9825f82ca3ae
boundary condition: true
has only substance units: false
is encoded by: hsa:5172
initial concentration: NaN
constant: false
is: O43511
type: Species
is: SBO:0000252
name: SLC26A4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_92d39f02_5df9_42f7_970b_7cfdc9138130
has only substance units: false
initial concentration: NaN
type: Species
is: P49448
is encoded by: hsa:2747
name: GLUD2
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR r1593
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_25bb8d70_b13a_4e33_9c2f_b269c93cd547
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: Q13370
name: PDE3B
is encoded by: hsa:5140
initial concentration: NaN

metaM tetde5coa x
initial concentration: 1.0
type: Species
name: 5-tetradecenoylcoa
constant: false
initial amount: NaN
is: C05279
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: HMDB11123

metaR R group phosphotase 3
name: R group phosphotase 3
reversible: false
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaR NACHEX25ly
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction
product: MODEL1310110013#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110013#

metaR DM anth
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_eefb8c85_2516_4489_abb7_de1aa7da44d5
name: ATP5L
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10632
is: O75964
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaR FUMSO3tm
modifier: MODEL1310110013#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110013#
name: Fumarate:sulfite antiport, mitochondrial
is: SBO:0000185

metaM q10 c
is: SBO:0000247
is: CHEBI:46245
type: Species
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: ubiquinone-10
is: HMDB01072
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378

metaR PPCOAOm
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
fast: false
is described by: ECO:0000269
reversible: false

metaR PROSTGE1t
is: SBO:0000185
name: prostaglandin transport via bicarbonate countertransport
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110013#
is described by: ECO:0000269
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction

metaM trdox c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:18191
constant: false
type: Species
boundary condition: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: C00343
name: Oxidized thioredoxin
is: SBO:0000247

metaM dec47dicoa x
name: 4,7-decadienoylcoa
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

metaR r1594
reactant: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110013#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110013#
fast: false

metaR r1595
reversible: true
fast: false
reactant: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#

metaM acald e
is: CHEBI:15343
has only substance units: false
is: SBO:0000247
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
initial concentration: 1.0
boundary condition: false
is: HMDB00990
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_b0ba9719_ef69_43e5_9d55_8e9173cf66a2
is: D3DTL2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: ENO3
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:2027
constant: false

metaR FAOXC185m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR r2120
kinetic law: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
modifier: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2526
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
fast: false
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_a440c526_d102_4804_9286_4ba11eb19d60
name: ZADH2
is: Q4G1C4
is: SBO:0000252
is encoded by: hsa:284273
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_9f89431e_7bdf_42cf_ac5a_e3cacfa66d6b
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:50808
type: Species
initial amount: NaN
name: AK3
is: E7ET30
boundary condition: true
is: SBO:0000252

metaR r0734
is described by: ECO:0000000
type: Reaction
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
reactant: MODEL1310110013#

metaR BAAT1x
name: bile acid Coenzyme A: amino acid N-acyltransferase
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
reversible: false
product: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4f29a605_432f_4d79_91a3_6a15818a5f94
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PANK1
is encoded by: hsa:53354
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q8TE04

metaM lnlncgcoa r
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)
boundary condition: false
is: HMDB06368
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4d6d6e1f_2596_4e27_9932_b41d3bcdf82d
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: GSTZ1
constant: false
is encoded by: hsa:2954
has only substance units: false

metaR r1596
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185

metaM xylu L c
is: HMDB00751
name: L-xylulose
boundary condition: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
is: CHEBI:17399
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_1b7d73dc_f251_4521_8474_aa889db2c097
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:80025
name: PANK2
is: Q9BZ23

metaM ser L m
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00187
boundary condition: false
is: CHEBI:17115
initial amount: NaN
name: L-serine
has only substance units: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
constant: false

metaM ksii core4 deg1 l
has only substance units: false
constant: false
type: Species
name: keratan sulfate II (core 4-linked), degradation product 1
initial amount: NaN
is: SBO:0000247
is: HMDB00868
initial concentration: 1.0
is: CHEBI:57737
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
boundary condition: false

metaM q10 m
has only substance units: false
boundary condition: false
is: CHEBI:46245
initial amount: NaN
name: ubiquinone-10
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
type: Species
constant: false
initial concentration: 1.0
is: HMDB01072

http://identifiers.org/biomodels.db/MODEL1310110013#_92ecc816_a0fa_4566_8460_96b44f58b533
has only substance units: false
name: PRDX2
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:7001
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_41b98e75_a769_44e7_a5ca_8274e36a0b47
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q9Y4K0
has only substance units: false
boundary condition: true
is encoded by: hsa:4017
constant: false
name: LOXL2

metaM CE2435 m
has only substance units: false
type: Species
constant: false
is: CHEBI:57795
name: trans,cis-deca-2,4-dienoyl-CoA
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR r0060
kinetic law: MODEL1310110013#
fast: false
name: L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:
product: MODEL1310110013#
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_80375a5a_acf9_4980_a5a3_b5acd1702cf9
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: ALAS1
is: SBO:0000252
is: P13196
constant: false
is encoded by: hsa:211

metaR r2525
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
reactant: MODEL1310110013#

metaR r0733
modifier: MODEL1310110013#
product: MODEL1310110013#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.5.1.12

http://identifiers.org/biomodels.db/MODEL1310110013#_afa2e24e_4bab_433d_90c0_e32fcfd4e36f
name: PI4KA
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:5297
constant: false
is: SBO:0000252
is: B4DYG5
type: Species

metaR PTDCACRNCPT2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reversible: false
name: pentadecanoate transport into the mitochondria
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaR r1597
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
reversible: true
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GLCt4
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
name: glucose transport via sodium symport
reversible: true
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaR ALAtN1
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Alanine transport (Na, H coupled)
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true
modifier: MODEL1310110013#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_e7d7afcd_32e1_462e_bea8_c0ad5930fce1
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: E2QC23
is encoded by: hsa:23464
name: GCAT
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_3e86ccd1_e411_48f9_a371_f56e474e148c
is: SBO:0000252
constant: false
type: Species
name: ATG9B
is encoded by: hsa:285973
is: Q674R7
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r2122
modifier: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR GLYCLTtp
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
name: glycolate transport into peroxisome
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR PTDCACRNCPT1
product: MODEL1310110013#
is: SBO:0000176
name: carnitine fatty-acyl transferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
kinetic law: MODEL1310110013#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110013#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_2ca317a6_b322_464b_b2cb_2d71b427ab38
boundary condition: true
type: Species
is: SBO:0000252
name: ARSB
initial amount: NaN
has only substance units: false
is encoded by: hsa:411
initial concentration: NaN
constant: false
is: A8K4A0

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR r1598
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110013#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR RE2541E
is described by: ECO:0000000
fast: false
is: SBO:0000176
reactant: MODEL1310110013#
name: RE2541
type: Reaction
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
modifier: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true
kinetic law: MODEL1310110013#

metaR r2121
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR r0735
is described by: ECO:0000000
product: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_cd289789_d548_4d64_b351_eb4263c4b734
is encoded by: hsa:10935
is: E9PH29
initial amount: NaN
is: SBO:0000252
name: PRDX3
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR DGSNtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
kinetic law: MODEL1310110013#
name: deoyguanosine transport in mitochondria
product: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
type: Reaction

metaR r2124
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000185
modifier: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#

metaR r0730
fast: false
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
type: Reaction
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR r1599
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_5bb2e8e2_49cf_449c_9e9e_6d6e31ef35d9
initial amount: NaN
constant: false
initial concentration: NaN
name: VNN3
type: Species
is encoded by: hsa:55350
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_7d65a6dd_731b_482c_9e78_25e96491cd48
is encoded by: hsa:219
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: ALDH1B1
is: SBO:0000252
boundary condition: true
is: P30837

http://identifiers.org/biomodels.db/MODEL1310110013#_656127de_bb91_48cd_b73b_b1967fc2d30f
constant: false
initial concentration: NaN
name: SLC8A3
is encoded by: hsa:6547
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_e2905ebd_c40c_4f3a_9228_968d8c5b8225
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P00441
constant: false
name: SOD1
initial amount: NaN
is encoded by: hsa:6647

metaM acgal1p c
is: HMDB06480
is: SBO:0000247
type: Species
name: N-Acetyl-D-galactosamine 1-phosphate
is: CHEBI:55404
constant: false
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR S6TASE12ly
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaR r2123
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR NRVNCCOAtx
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
is: SBO:0000185
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110013#_9d9f4a18_9b78_441f_a777_5d992768b2a8
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:262
constant: false
is: P17707
type: Species
initial amount: NaN
has only substance units: false
name: AMD1

metaM 3mop c
name: 3-methyl-2-oxopentanoate
has only substance units: false
initial amount: NaN
is: HMDB00491
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
constant: false
is: CHEBI:28654
type: Species

metaM taur c
has only substance units: false
is: HMDB00251
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:3544
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0
name: Taurine
is: SBO:0000247
is: C00245

metaM lnlncgcoa m
name: gamma-linolenoyl-CoA(4-)
is: HMDB06368
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
initial concentration: 1.0

metaM CE2418 m
has only substance units: false
is: HMDB11123
type: Species
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:28387
initial amount: NaN

metaR FAOXC221C201x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_b585d958_b111_47d1_86dd_c5c38d135dc0
name: CCBL1
has only substance units: false
is encoded by: hsa:883
type: Species
constant: false
is: Q16773
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_82b6312c_9c5c_414f_9377_e1e394b945e6
boundary condition: true
is encoded by: hsa:36
is: SBO:0000252
is: P45954
constant: false
initial amount: NaN
has only substance units: false
name: ACADSB
initial concentration: NaN
type: Species

metaM HC01115 c
is: SBO:0000247
constant: false
is: CHEBI:29025
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
has only substance units: false
initial amount: NaN
type: Species
name: NeuNGc
initial concentration: 1.0
boundary condition: false

metaM tmndnccoa m
is: HMDB06514
has only substance units: false
name: timnodonyl coenzyme A
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_692fdc24_9b3c_46a4_a393_0103629c42da
is encoded by: hsa:501
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: ALDH7A1
constant: false
boundary condition: true
initial amount: NaN
is: E7EPT3
type: Species

metaM uacgam g
boundary condition: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
type: Species
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00290
is: CHEBI:57705
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_8da614e5_c9c2_4f5e_9ee6_936eff13eea0
initial amount: NaN
name: UGCG
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: Q16739
constant: false
is encoded by: hsa:7357

metaR KSII CORE2tly
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: keratan sulfate II (core 2) transport, extracellular to lysosome
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaR r2126
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110013#
product: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false

metaM HC02187 c
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
is: CHEBI:28774
initial concentration: 1.0
is: SBO:0000247
constant: false
name: reverse-triiodthyronine
has only substance units: false

metaM lnlncacoa c
initial amount: NaN
has only substance units: false
name: alpha-Linolenoyl-CoA
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
constant: false
type: Species
is: HMDB06290
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:51985

metaM acald c
is: CHEBI:15343
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
name: acetaldehyde

metaR FUMTSULtm
name: Fumarate:thiosulfate antiport, mitochondrial
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
reversible: true
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_37a88fa9_563e_472e_bee2_951b6f9c2a66
constant: false
is: SBO:0000252
boundary condition: true
name: _AA278423_1_c
type: Species
is encoded by: hsa:AA278423
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR r0732
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false
reversible: false
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_3191b77f_f14b_4bf2_9d18_0e2b7762ed00
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ATP5G2
constant: false
boundary condition: true
is: SBO:0000252
is: Q06055
is encoded by: hsa:517
type: Species

metaR NACHEX19ly
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1 and 3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
product: MODEL1310110013#

metaM HC01180 c
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:58694
name: D-tagatofuranose 1,6-bisphosphate(4-)
is: SBO:0000247
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_33215c0a_a94a_44dd_bf3f_459c3f5bc841
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:4712
is: SBO:0000297
constant: false
is encoded by: hsa:4731
initial concentration: NaN
initial amount: NaN
has part: Q5VYT2

metaR r2125
modifier: MODEL1310110013#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110013#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110013#

metaM etfox m
initial amount: NaN
is: C00631
notes: FORMULA: R CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3904
is: HMDB03391
is: CHEBI:58289
name: Electron transfer flavoprotein oxidized

http://identifiers.org/biomodels.db/MODEL1310110013#_3e0185c6_a939_4e2b_8a70_43ccf2203e2c
is: E9PAY8
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8612
constant: false
has only substance units: false
name: PPAP2C
type: Species
is: SBO:0000252

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaR DAG HSter
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110013#
is: SBO:0000185
name: diacylglycerol ER export
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110013#
fast: false

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_1a9b48d4_58c3_416a_a006_663ef9adb8ea
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: SCD
is encoded by: hsa:6319
boundary condition: true
is: O00767
initial concentration: NaN
is: SBO:0000252

metaR HEXDICOAACBPx
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaM r1p c
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: CHEBI:57720
is: HMDB01489
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: C00442
name: alpha-D-Ribose 1-phosphate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_02f514ab_593a_4d3d_bc36_1395ba39f46b
name: _AI769281_1_e
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI769281
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_e0903a95_64f8_46e6_9d57_8dd9984df85e
initial concentration: NaN
is: Q6I9V5
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC25A6
initial amount: NaN
type: Species
is encoded by: hsa:293
constant: false

metaM glu5sa m
is: CHEBI:17232
is: C01165
is: HMDB02104
name: L-Glutamate 5-semialdehyde
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
constant: false
type: Species
has only substance units: false
is: SBO:0000247

metaR r0731
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110013#
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110013#_40354cf4_07b7_4510_a551_f363257eb4c8
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is: Q16718
is encoded by: hsa:4698
name: NDUFA5

metaR SBTR
product: MODEL1310110013#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110013#
name: D-sorbitol reductase
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
kinetic law: MODEL1310110013#

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM gam e
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: CHEBI:17315
has only substance units: false
name: D-Glucosamine
type: Species
is: HMDB01514
boundary condition: false
initial concentration: 1.0
is: C00329
initial amount: NaN
is: SBO:0000247
constant: false

metaR H2O2tp
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110013#
name: hydrogen peroxide peroxisomal transport via diffusion
reactant: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: true

metaR r0941
is described by: ECO:0000000
reactant: MODEL1310110013#
reversible: true
fast: false
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
is: SBO:0000185

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_1d911a00_2c6e_47f2_91d6_7d06a2cc1a77
is: SBO:0000252
name: GGT7
is: A0PJJ9
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2686

http://identifiers.org/biomodels.db/MODEL1310110013#_e0c71c2e_e23f_4260_85d2_537e4a984b96
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3948
name: LDHC
initial amount: NaN
is: P07864
is: SBO:0000252
constant: false
has only substance units: false

metaR r1154
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
name: EC:1.2.7.2
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000176

metaM hdca e
notes: FORMULA: C16H31O2 CHARGE: -1
name: Hexadecanoate (n-C16:0)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:0
has only substance units: false
constant: false
is: HMDB00220
initial amount: NaN
boundary condition: false
is: C00249
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_d4591bed_d23c_4b07_9ec9_93e82e2874d8
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: CA12
initial concentration: NaN
is encoded by: hsa:771
is: O43570
constant: false

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaM ade e
is: CHEBI:16708
has only substance units: false
is: HMDB00034
constant: false
type: Species
name: adenine
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247

metaM taur e
is: SBO:0000247
boundary condition: false
is: HMDB00251
has only substance units: false
type: Species
name: Taurine
is: C00245
initial concentration: 1.0
is: CHEBI:3544
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_6f7fa2ff_a0f7_4522_8d7c_f91f4cafd51f
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000297
boundary condition: true
is encoded by: hsa:498
has only substance units: false
has part: B4DY56
type: Species

metaM cholp c
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:295975
type: Species
name: choline phosphate(1-)
constant: false

metaR r0942
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
type: Reaction
reactant: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_43c07fe1_c03e_4ee4_8175_a18381bc8f6e
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2645
is: SBO:0000252
has only substance units: false
name: GCK
is: Q53Y25
constant: false

metaR r1008
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
type: Reaction
reversible: false
name: Facilitated diffusion
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

metaM 3hbcoa m
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB01166
is: CHEBI:57316
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_6c76f470_6ae9_4dd5_b3d7_6d59e406fce6
boundary condition: true
has part: Q6I9V2
has only substance units: false
is: SBO:0000297
has part: P25705
initial amount: NaN
constant: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:498
initial concentration: NaN
is encoded by: hsa:509
type: Species

metaM hs deg16 l
initial concentration: 1.0
is: CHEBI:21338
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB02704
name: heparan sulfate, degradation product 16
has only substance units: false
constant: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaM idour c
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: HMDB02704
name: L-iduronate
is: CHEBI:21338
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM btamp c
is: HMDB04220
constant: false
name: Biotinyl-5'-AMP
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:3110
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921

http://identifiers.org/biomodels.db/MODEL1310110013#_5a514262_07f8_42ef_b1ea_36513709bb1c
initial concentration: NaN
boundary condition: true
has only substance units: false
name: NPR2
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4882
constant: false

metaM cs b l
initial concentration: 1.0
is: CHEBI:36005
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
initial amount: NaN
is: HMDB02183
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_74b1be9e_e2e5_41c6_99fa_26d7328954ee
constant: false
boundary condition: true
name: NDUFB1
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: O75438
is encoded by: hsa:4707
initial concentration: NaN

metaM gam c
is: HMDB01514
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
name: D-Glucosamine
is: SBO:0000247
constant: false
is: C00329
is: CHEBI:17315
boundary condition: false
type: Species
initial amount: NaN

metaR r1007
is: SBO:0000185
type: Reaction
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110013#
name: Facilitated diffusion
reversible: true
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_8096409c_a18e_43ec_8b07_9d7964ecb3a3
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:80864
is: SBO:0000252
initial amount: NaN
is: Q99944
name: EGFL8
type: Species
constant: false

metaR H2O2tn
is described by: ECO:0000000
product: MODEL1310110013#
fast: false
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
name: hydrogen peroxide nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
reversible: true

metaR MALSO3tm
product: MODEL1310110013#
name: Malate:sulfite antiport, mitochondrial
fast: false
modifier: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000269

metaM hdca c
type: Species
is: CHEBI:7896
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: palmitate
constant: false
boundary condition: false
is: HMDB00220
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaM homoval m
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: Homovanillate
constant: false
initial concentration: 1.0
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: CHEBI:545959
is: HMDB00118

http://identifiers.org/biomodels.db/MODEL1310110013#_98a2a8d4_469f_4f99_acfd_3205fc367e5b
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: GMPR2
is encoded by: hsa:51292

metaM n2m2nmasn e
boundary condition: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: SBO:0000247
is: C04946
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial amount: NaN

metaM chol m
is: SBO:0000247
boundary condition: false
is: CHEBI:15354
has only substance units: false
name: choline
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097

metaR DEBRISOQUINEt
type: Reaction
name: debrisoquine uniport
notes: GENE_ASSOCIATION: (6582.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110013#
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#

metaM cs a deg2 l
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: HMDB00127
notes: FORMULA: C37H55NO38S2 CHARGE: -4
type: Species
boundary condition: false
is: CHEBI:15748
constant: false

metaM btcoa c
is: CHEBI:57371
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01088
type: Species
is: C00136
boundary condition: false
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
name: Butanoyl-CoA

metaM 3odcoa m
constant: false
is: HMDB03939
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:28528
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
name: 3-Oxodecanoyl-CoA

metaM dgchol c
constant: false
is: SBO:0000247
name: glycochenodeoxycholate
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:36252
initial concentration: 1.0
initial amount: NaN
is: HMDB00637

metaR FAOXC140
reversible: false
type: Reaction
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000269

metaR LTC4CP
fast: false
is described by: ECO:0000000
name: Leukotriene C4 carboxypeptidase
is: SBO:0000176
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
type: Reaction
product: MODEL1310110013#

metaR r0940
name: Free diffusion
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110013#
is: SBO:0000185
fast: false
type: Reaction
reactant: MODEL1310110013#

metaM CE2421 m
is: CHEBI:30623
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB02329
type: Species
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
name: (3S)-3-hydroxylinoleoyl-CoA
is: SBO:0000247

metaR DESAT24 1
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
reversible: false
is described by: ECO:0000269
fast: false
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)

metaM cs e l
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB02183
has only substance units: false
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
type: Species
is: CHEBI:36005

metaM cs e deg1 l
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57737
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
is: SBO:0000247
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00868

metaM pail35p hs c
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57923

metaR GAPD
is version of: http://identifiers.org/ec-code/1.2.1.12
kinetic law: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
reactant: MODEL1310110013#
type: Reaction
name: glyceraldehyde-3-phosphate dehydrogenase
reversible: true
is described by: ECO:0000134
modifier: MODEL1310110013#
fast: false

metaM chol n
constant: false
type: Species
boundary condition: false
is: CHEBI:15354
is: HMDB00097
name: choline
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN

metaR r1177
fast: false
reversible: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
name: EC:3.1.1.13
type: Reaction
reactant: MODEL1310110013#

metaM idour e
is: HMDB02704
name: L-iduronate
is: CHEBI:21338
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_80cb44e6_395f_466c_8393_949f8661026a
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:7991
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_655b65dd_193a_4646_ab7c_4cabcecc0efd
initial concentration: NaN
is: P48448
has only substance units: false
name: ALDH3B2
constant: false
is encoded by: hsa:222
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaR AKR1D2
is version of: http://identifiers.org/ec-code/1.3.1.3
fast: false
is described by: ECO:0000269
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
type: Reaction
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_5f971313_f3d9_42f6_9f8f_172354c94a86
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:7084
is: O00142
name: TK2
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7513a1ae_9191_46c6_884d_27683c677077
constant: false
initial concentration: NaN
has only substance units: false
name: SLC34A2
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:10568
is: O95436

http://identifiers.org/biomodels.db/MODEL1310110013#_a6bc2a38_32f9_460a_98f1_b1b4a9b370b4
initial concentration: NaN
is encoded by: hsa:518
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ATP5G3
type: Species

metaR FUCtly
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
name: L-fucose efflux from lysosome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110013#

metaR GLCNACASE2ly
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110013#

metaR r0074
reversible: true
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110013#
reactant: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
kinetic law: MODEL1310110013#
is: SBO:0000176

metaM chol g
is: HMDB00097
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: choline
constant: false
is: CHEBI:15354
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_5b4dcb3c_aefa_4499_bf18_55e4a8b19c2f
is encoded by: hsa:100
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: ADA
initial amount: NaN
constant: false
initial concentration: NaN
is: P00813

http://identifiers.org/biomodels.db/MODEL1310110013#_f7e4dd12_d3c7_45e3_8a35_074037cdcf61
boundary condition: true
is encoded by: hsa:AI620219
constant: false
has only substance units: false
name: _AI620219_1_m
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_5c52ca80_9fbd_4033_9350_c40f5564f33e
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR LDH D
is version of: http://identifiers.org/ec-code/1.1.2.4
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
is described by: ECO:0000304
reactant: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
fast: false
reversible: true
name: D-lactate dehydrogenase
type: Reaction

metaR CLHCO3tex2
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
reversible: false
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
name: chloride transport via bicarbonate countertransport (2:1)
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

metaM dsT antigen g
initial amount: NaN
type: Species
has only substance units: false
name: disialyl-T antigen
is: HMDB01440
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16497
boundary condition: false
notes: FORMULA: C36H56N3O26X CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110013#_602653a8_5dc5_43e2_8a39_80a40424ed19
type: Species
is encoded by: hsa:514
initial concentration: NaN
constant: false
is encoded by: hsa:513
has only substance units: false
is: SBO:0000297
initial amount: NaN
boundary condition: true
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E

metaR MANt1r
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
reversible: true
name: mannose transport (uniport)
reactant: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaM ksi deg15 l
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:12936
type: Species
constant: false
is: HMDB00143
initial amount: NaN
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
name: keratan sulfate I, degradation product 15
is: SBO:0000247

metaR RE2625M
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE2625
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_92b35f71_f588_4b5b_89ed_84a09cc00bc2
name: UPB1
type: Species
is encoded by: hsa:51733
boundary condition: true
constant: false
is: B3KNC1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaR r0728
reversible: true
is: SBO:0000176
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_8017cb40_f148_4f71_8ee4_81c88a96187a
is: Q92835
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3635
boundary condition: true
has only substance units: false
name: INPP5D
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_19643e5b_3dde_4278_904f_b134b0cbfab8
is encoded by: hsa:5151
type: Species
is: SBO:0000252
name: PDE8A
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

metaR CYTK5n
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
modifier: MODEL1310110013#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110013#
reactant: MODEL1310110013#

metaR Rtotaltl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
name: fatty acid intracellular transport
fast: false
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR DCSPTN1t
reactant: MODEL1310110013#
is described by: ECO:0000000
reversible: true
fast: false
name: fatty acid transport via diffusion
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_3e8dd2eb_810e_47e1_a429_5852e6316897
name: IDH1
boundary condition: true
constant: false
is: O75874
is encoded by: hsa:3417
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

metaR GUAD
is: SBO:0000176
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
name: guanine deaminase
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.3
kinetic law: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (9615.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.3 Confidence Level: 4 AUTHORS: PMID:10075721 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_204ee650_28f1_4a85_ac01_b25a7c2dccf2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI440329
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
name: _AI440329_1_r

metaR ALAR
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110013#
reversible: true
name: alanine racemase
type: Reaction
is: SBO:0000176
is described by: ECO:0000212
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#

metaM aacoa m
name: acetoacetyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01484
has only substance units: false
constant: false
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: CHEBI:57286

metaM acgam1p c
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
name: N-Acetyl-D-glucosamine 1-phosphate
is: HMDB01367
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:7125
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM malthp e
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
name: maltoheptaose
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: C01936
is: SBO:0000247
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
boundary condition: false

metaR SQLSr
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
product: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.21
is described by: ECO:0000134
reactant: MODEL1310110013#
is: SBO:0000176
name: Squalene synthase
kinetic law: MODEL1310110013#

metaR r1156
is: SBO:0000176
fast: false
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
reversible: true
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_6e97bd1e_a64a_4f80_9696_65b52ed125e2
is: Q9Y6L6
initial amount: NaN
name: SLCO1B1
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:10599
initial concentration: NaN

metaR 4HPRO LTte
kinetic law: MODEL1310110013#
type: Reaction
name: Transport of trans-4-hydroxy-L-proline
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000134
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_02322d77_5ea5_4bbc_b3e0_91f673adb1ec
constant: false
initial amount: NaN
initial concentration: NaN
name: PPT1
is: Q6FGQ4
is encoded by: hsa:5538
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaR r0726
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.33
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_09abe418_0de3_4971_907a_3308ebeabc4a
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8875
type: Species
is: SBO:0000297
is encoded by: hsa:55350
name: VNN3:VNN2:VNN1
has part: O95498
has only substance units: false
constant: false

metaR PHYCBOXL
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
fast: false
reactant: MODEL1310110013#
name: L-Phenylalanine carboxy-lyase
kinetic law: MODEL1310110013#
is described by: ECO:0000212
modifier: MODEL1310110013#

metaM HC01162 c
has only substance units: false
initial concentration: 1.0
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
constant: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: CHEBI:58376
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR PCHOL HSter
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: phosphatidylcholine scramblase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_2e029958_9a58_4776_aad2_52c9ac7ad74f
is encoded by: hsa:6548
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P19634
constant: false
type: Species
boundary condition: true
name: SLC9A1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_f3f89904_827f_4577_855e_095febd4a769
name: ITPKA
is encoded by: hsa:3706
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is: P23677
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_3baf39ce_4677_493a_a1be_f7012ccf21f9
boundary condition: true
is encoded by: hsa:NM 013421
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: _NM_013421_1_m
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_824a2999_4303_4b03_92b8_8fcefc1f042f
is encoded by: hsa:60482
initial amount: NaN
type: Species
constant: false
name: SLC5A7
is: Q9GZV3
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM lnlncgcoa c
is: HMDB06368
boundary condition: false
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: SBO:0000247
has only substance units: false
type: Species
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
initial concentration: 1.0
constant: false

metaR EX aflatoxin LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: aflatoxin B1 exchange
type: Reaction

metaR HDD2COAtx
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110013#
name: hdd2coa intracellular transport
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
fast: false
is: SBO:0000185
reversible: true

metaM idour l
is: CHEBI:21338
is: SBO:0000247
name: L-iduronate
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB02704
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1

metaR HDCAter
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
name: palmitate ER export
reversible: false

metaR r0618
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
fast: false
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_ea7d7a95_30de_4bd6_97d4_98c69ee9f6b0
initial amount: NaN
type: Species
is: SBO:0000252
name: SULT1A3
constant: false
has only substance units: false
boundary condition: true
is: Q1ET61
is encoded by: hsa:6818
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_54297301_1c37_4fc1_b374_f8e3eef9ddba
name: MTHFD1L
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:25902
boundary condition: true
is: B2RD24
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_acb631ed_310a_48bd_805d_8afb9666164f
is: Q549M5
is encoded by: hsa:4718
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
name: NDUFC2
boundary condition: true

metaR LTA4H
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.3.2.6
modifier: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000134
name: Leukotriene A-4 hydrolase
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
is: SBO:0000176
reversible: false
reactant: MODEL1310110013#
fast: false

metaM dec47dicoa m
name: 4,7-decadienoylcoa
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966

metaR FK
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
name: Fucokinase
is version of: http://identifiers.org/ec-code/2.7.1.52
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
reactant: MODEL1310110013#
fast: false
reversible: false

metaR PAPtg
reversible: false
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
name: adenosine 3',5'-bisphosphate Golgi transport
kinetic law: MODEL1310110013#
is described by: ECO:0000000
type: Reaction

metaR RE3272N
type: Reaction
name: RE3272
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reactant: MODEL1310110013#
fast: false

metaR UMPKn
modifier: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110013#
name: UMP kinase, nuclear
reversible: true
is: SBO:0000176
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD

metaR S4TASE5ly
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_a71eaaef_0524_4109_ba38_e0bf1506f86b
is: Q8IW54
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: PDE2A
constant: false
boundary condition: true
is encoded by: hsa:5138
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_3482a71e_017f_48fb_9c45_c0801c54dae0
initial amount: NaN
is: SBO:0000252
is: O43677
constant: false
is encoded by: hsa:4717
has only substance units: false
name: NDUFC1
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_aef1f382_24de_4271_8b21_c9b375e202d5
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: Q5MY95
is encoded by: hsa:377841
initial concentration: NaN
boundary condition: true
name: ENTPD8
has only substance units: false

metaR DURAD
name: dihydrouracil dehydrogenase (NADP)
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is: SBO:0000176
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.1.2
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_b4803fa4_7bdb_4236_923f_2cce74f78b74
constant: false
boundary condition: true
name: LDHA
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is: P00338
initial amount: NaN
is encoded by: hsa:3939

metaM gdpfuc c
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial concentration: 1.0
is: HMDB01095
is: CHEBI:57984
name: GDP-L-fucose(2-)
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN

metaR NODe
reactant: MODEL1310110013#
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110013#
name: NODe
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110013#_6575be03_dbc2_4fcd_8d8a_b3d9ebc5f897
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI971023
initial concentration: NaN
has only substance units: false
name: _AI971023_1_c
boundary condition: true

metaR r0616
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110013#

metaR NS26T2g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110013#

metaM ksii core2 deg4 l
is: CHEBI:57455
is: SBO:0000247
is: HMDB01354
boundary condition: false
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 4
notes: FORMULA: C58H95N5O43SX CHARGE: -1
type: Species
constant: false
has only substance units: false
initial amount: NaN

metaR NDP7er
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_5bc9660b_0b9a_4b9c_aac0_ec693ae15698
boundary condition: true
name: _R06874_1_r
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:R06874

metaR GPIDA2er
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reversible: false
type: Reaction
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
is: SBO:0000176
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
modifier: MODEL1310110013#

metaM btamp m
has only substance units: false
boundary condition: false
initial amount: NaN
name: Biotinyl-5'-AMP
type: Species
is: HMDB04220
initial concentration: 1.0
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
constant: false
is: SBO:0000247
is: CHEBI:3110

metaM n2m2nmasn l
notes: FORMULA: C58H96N5O40X CHARGE: 0
has only substance units: false
constant: false
boundary condition: false
type: Species
is: C04946
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R

metaM acgam r
is: CHEBI:17411
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
initial amount: NaN
name: N-acetyl-D-glucosamine
is: SBO:0000247
initial concentration: 1.0
is: HMDB00215
type: Species
has only substance units: false

metaR BUTt2r
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000269
name: Butyrate transport via proton symport, reversible
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_fabbc627_7f41_4b45_9f46_47836bc26aeb
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:518
constant: false
name: ATP5G3
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN

metaR r0617
type: Reaction
product: MODEL1310110013#
reversible: true
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110013#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110013#
is described by: ECO:0000000

metaR RE2999M
product: MODEL1310110013#
name: RE2999
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_2e2f8a1f_405a_47ee_8652_bb4fd2fe9a5f
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:2109
initial amount: NaN
name: ETFB
constant: false

metaR FAOXC226
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
is described by: ECO:0000000

metaR 4NPHSULT
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
is version of: http://identifiers.org/ec-code/2.8.2.1
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
name: 4-Nitrophenol Sulfotransferase
is described by: ECO:0000269

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR ALR2
is: SBO:0000176
fast: false
name: aldose reductase (methylglyoxal)
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
is described by: ECO:0000269

metaR B3GALT3g
reversible: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.79
reactant: MODEL1310110013#
is described by: ECO:0000269
name: Beta-1,3-galactosyltransferase 3
is: SBO:0000176
fast: false

metaR PI45P3K
reversible: false
modifier: MODEL1310110013#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
reactant: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.11.1
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110013#

metaM 2octpencoa m
boundary condition: false
name: 2,6,9,12,15-octadecapentenoylcoa
constant: false
has only substance units: false
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
type: Species
initial amount: NaN
is: SBO:0000247

metaM hmgcoa x
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
is: SBO:0000247
boundary condition: false
is: CHEBI:15467
name: Hydroxymethylglutaryl-CoA
constant: false
is: HMDB01375
type: Species

metaR ALR3
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110013#
name: aldose reductase (acetol)

metaM utp n
initial concentration: 1.0
is: CHEBI:46398
is: SBO:0000247
is: HMDB00285
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_db38f63d_2b3e_409c_83da_21b4a68abe09
is encoded by: hsa:953
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ENTPD1
has only substance units: false
boundary condition: true
constant: false
is: Q86VV3

http://identifiers.org/biomodels.db/MODEL1310110013#_a1b7a913_09d4_4e5a_a147_ee6720afd216
name: GBA
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is: P04062
boundary condition: true
initial amount: NaN
is encoded by: hsa:2629
is: SBO:0000252

metaM acgam l
initial concentration: 1.0
type: Species
is: HMDB00215
has only substance units: false
is: CHEBI:17411
constant: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
initial amount: NaN
name: N-acetyl-D-glucosamine

metaM hx2coa x
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
boundary condition: false
name: trans-Hex-2-enoyl-CoA
type: Species

metaR DESAT22 2p
is described by: ECO:0000000
product: MODEL1310110013#
type: Reaction
reversible: false
reactant: MODEL1310110013#
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#

metaM ocdcea e
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
has only substance units: false
is: HMDB00207
is: C00712
is: CHEBI:0
constant: false
name: octadecenoate (n-C18:1)

metaR ASNtN1
is: SBO:0000185
reversible: true
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
name: Asparagine transport (Na, H coupled)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaM ade c
type: Species
is: CHEBI:16708
is: HMDB00034
name: Adenine
boundary condition: false
is: C00147
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_128e550d_97ab_4cec_abe0_d236421342c0
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:516
type: Species
is: SBO:0000252
name: ATP5G1
is: Q6FIH7
initial concentration: NaN
boundary condition: true

metaR SCPx
is described by: ECO:0000269
is: SBO:0000176
name: peroxisomal thiolase 2
fast: false
type: Reaction
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR r0830
is version of: http://identifiers.org/ec-code/3.5.4.16
modifier: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_923046b9_6982_4e29_81a3_943f5bfced87
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:522
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P18859
name: ATP5J
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_bb4a81cd_b61e_4fc6_8173_30e7108d3f22
is encoded by: hsa:218
is: P30838
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: ALDH3A1

http://identifiers.org/biomodels.db/MODEL1310110013#_14b56573_373f_4af9_9f73_e29709dc60f6
type: Species
has only substance units: false
is: SBO:0000252
is: P43251
constant: false
initial concentration: NaN
is encoded by: hsa:686
name: BTD
boundary condition: true
initial amount: NaN

metaM methf m
is: CHEBI:57455
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: (6R)-5,10-methenyltetrahydrofolate
boundary condition: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
type: Species
is: HMDB01354
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_b59e03cf_af61_4e53_af24_1abc9d7ea44e
name: AKR1C4
is: P17516
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1109
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_6235315e_aa3d_4f25_b63c_ce295f511337
has only substance units: false
is: P30837
is encoded by: hsa:219
constant: false
boundary condition: true
is: SBO:0000252
name: ALDH1B1
type: Species
initial concentration: NaN
initial amount: NaN

metaR FAOXC184x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaR RE1523M
modifier: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reactant: MODEL1310110013#
name: RE1523
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaM ocdcea c
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00207
is: C00712
is: CHEBI:0
constant: false
name: octadecenoate (n-C18:1)

metaM gam6p c
is: HMDB01254
initial concentration: 1.0
is: CHEBI:12962
boundary condition: false
name: D-Glucosamine 6-phosphate
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
initial amount: NaN

metaM leuktrC4 c
is: HMDB01198
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: SBO:0000247
initial amount: NaN
is: CHEBI:57973
type: Species
constant: false
name: leukotriene C4(2-)
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR ADNt
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
is: SBO:0000185
name: adenosine facilated transport in cytosol
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
modifier: MODEL1310110013#
fast: false
type: Reaction

metaR GCHOLAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
type: Reaction
name: bile acid intracellular transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110013#

metaM f1a l
name: F1alpha
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:15936
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_3f784b72_c3ee_4104_bdb9_139e803c8806
type: Species
has only substance units: false
boundary condition: true
is: Q9P109
initial amount: NaN
is: SBO:0000252
name: GCNT4
is encoded by: hsa:51301
initial concentration: NaN
constant: false

metaM nmn c
is: HMDB00229
type: Species
is: CHEBI:14649
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
initial concentration: 1.0
is: C00455
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
name: NMN

metaR r0611
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
name: ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.3.1
type: Reaction

metaM 3octpencoa m
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
name: 3,6,9,12,15-octadecapentenoylcoa
notes: FORMULA: C39H56N7O17P3S CHARGE: -4

metaR r2118
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#

metaR NDP7ex
modifier: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
product: MODEL1310110013#
fast: false
name: nucleoside-diphosphatase (UDP), extracellular
reversible: false

metaM 2mop c
is: CHEBI:57700
constant: false
type: Species
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01172
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349

http://identifiers.org/biomodels.db/MODEL1310110013#_ac22e934_16a5_466c_826f_90bf8769cb18
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:9498
is: E7EML0
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC4A8

http://identifiers.org/biomodels.db/MODEL1310110013#_cd3a7e2d_9cff_48d8_92e4_30cf6f1dc715
is: G3XAD7
is encoded by: hsa:1583
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: CYP11A1
initial concentration: NaN
has only substance units: false

metaM ocdcea r
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
is: C00712
is: HMDB00207
boundary condition: false
name: octadecenoate (n-C18:1)
constant: false
is: SBO:0000247
is: CHEBI:0
initial amount: NaN
initial concentration: 1.0
type: Species

metaM dudp c
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: dUDP
is: C01346
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: CHEBI:60471

http://identifiers.org/biomodels.db/MODEL1310110013#_63240d12_bede_4353_853f_8c4c493ec1b7
is encoded by: hsa:8402
name: SLC25A11
initial amount: NaN
boundary condition: true
is: F5GY65
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaM dhbpt c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:20680
boundary condition: false
name: 6,7-dihydrobiopterin
is: HMDB00038
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_c9fe41fd_a70d_490a_9d69_426017b803f3
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:84720
name: PIGO

metaR r0517
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
modifier: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
reversible: true

metaR EX eaflatoxin LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 8,9 epxoy aflatoxin B1 exchange
type: Reaction

metaR r2117
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r0836
type: Reaction
modifier: MODEL1310110013#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110013#

metaR r0610
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:131802,PMID:1810251,PMID:193556,PMID:2987258,PMID:6091737 NOTES:
name: CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11
reactant: MODEL1310110013#

metaR GUAPRT
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
product: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
name: guanine phosphoribosyltransferase
is: SBO:0000176

metaM utp c
initial concentration: 1.0
is: CHEBI:46398
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00075
is: HMDB00285
boundary condition: false
name: UTP
constant: false

metaR BTNt2
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
name: Biotin reversible transport via proton symport
reversible: true
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
product: MODEL1310110013#

metaR Q10H2e
type: Reaction
reversible: true
kinetic law: MODEL1310110013#
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
is: SBO:0000185
name: transport of ubiquinol into lymph
is described by: ECO:0000134
reactant: MODEL1310110013#

metaM dopasf c
is: CHEBI:37946
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
name: dopamine 3-O-sulfate
initial amount: NaN
is: HMDB06275
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_1377fcb9_e184_4208_a69b_5f9c6d3ad349
name: CYP27A1
is: Q02318
type: Species
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:1593
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_92932a0e_63b1_4dc9_8a0e_682973f06139
is encoded by: hsa:AI694761
initial concentration: NaN
type: Species
name: _AI694761_1_c
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaM aacoa x
initial amount: NaN
boundary condition: false
name: acetoacetyl-CoA(4-)
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
is: SBO:0000247
is: CHEBI:57286
type: Species

metaR PIPLC
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is described by: ECO:0000000
reversible: false
fast: false
product: MODEL1310110013#
name: phosphatidylinositol phospholipase C

http://identifiers.org/biomodels.db/MODEL1310110013#_d7047a0f_8677_4cec_a8bc_6f284ae4d574
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:55577
is: Q9UJ70
name: NAGK
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

metaM trdrd c
constant: false
type: Species
boundary condition: false
is: CHEBI:15967
initial amount: NaN
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
has only substance units: false
initial concentration: 1.0
is: C00342
name: Reduced thioredoxin
is: SBO:0000247

metaM ksi deg26 l
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
name: keratan sulfate I, degradation product 26
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00061
initial amount: NaN
is: CHEBI:58343
initial concentration: 1.0
type: Species
has only substance units: false

metaM leuktrE4 c
initial amount: NaN
is: CHEBI:57462
has only substance units: false
name: leukotriene E4(1-)
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02200

metaM hdca r
is: SBO:0000247
is: C00249
constant: false
name: Hexadecanoate (n-C16:0)
initial amount: NaN
boundary condition: false
is: HMDB00220
is: CHEBI:7896
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaR RE2625C
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
name: RE2625
product: MODEL1310110013#
reversible: true
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_ccecc074_d04a_4a11_8f58_5e9a57756c0c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:54965
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q8TBF5
name: PIGX

http://identifiers.org/biomodels.db/MODEL1310110013#_7c3c15ef_aafd_40d7_9291_83ed0caccbd7
name: _AI348006_1_c
initial amount: NaN
type: Species
is encoded by: hsa:AI348006
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaR r2116
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110013#
is: SBO:0000185

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR r1454
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
is described by: ECO:0000000
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
type: Reaction
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_fa6ac670_bf03_4b97_816b_8e4f8b7c22b9
has only substance units: false
type: Species
is: Q9BWD1
is encoded by: hsa:39
name: ACAT2
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM HC01406 m
initial amount: NaN
constant: false
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:28264
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267

metaM taur x
is: CHEBI:15891
name: taurine
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
constant: false
is: HMDB00251
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r0834
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#

metaR MANt4
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
name: D-mannose transport via sodium cotransport
fast: false
modifier: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
reversible: true

metaR r2115
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#

metaM dopasf e
is: CHEBI:37946
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: dopamine 3-O-sulfate
is: SBO:0000247
is: HMDB06275

http://identifiers.org/biomodels.db/MODEL1310110013#_c6887727_0fa2_4a30_be7a_0b481b469a73
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:125206
constant: false
initial concentration: NaN
is: A0PJK1
type: Species
name: SLC5A10

http://identifiers.org/biomodels.db/MODEL1310110013#_aba00f3b_ab1b_4625_83a2_81e9fb3b22c7
is: B2RB13
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: ACSL6
boundary condition: true
is encoded by: hsa:23305
is: SBO:0000252
initial amount: NaN

metaR r0615
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
modifier: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.168

http://identifiers.org/biomodels.db/MODEL1310110013#_34543305_4076_4b44_974a_72106cc39504
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:D29675
name: _D29675_1_e
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaR r0514
name: Dihydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:4396284,PMID:6882460,PMID:962851 NOTES:

metaR DURAD2
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is described by: ECO:0000269
product: MODEL1310110013#
reversible: true
name: dihydrothymin dehydrogenase (NADP)
kinetic law: MODEL1310110013#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.2
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_08be80e1_d14a_40b4_8ca0_a5c3d63ecb40
constant: false
is encoded by: hsa:686
is: P43251
initial amount: NaN
has only substance units: false
boundary condition: true
name: BTD
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_f7e0f617_ae8a_43c0_90cd_e311896c3095
boundary condition: true
is: O15254
initial concentration: NaN
type: Species
has only substance units: false
name: ACOX3
is: SBO:0000252
is encoded by: hsa:8310
initial amount: NaN
constant: false

metaM glyb c
name: glycine betaine
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
has only substance units: false
is: CHEBI:17750
is: HMDB00043
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_0d12feee_00ed_4f54_9f80_7e9649a3b02b
boundary condition: true
name: SLC25A15
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:10166
initial concentration: NaN
is: Q9Y619
type: Species
is: SBO:0000252

metaR ORNt4m
reversible: true
name: ornithine mitochondrial transport exchange with citruline
type: Reaction
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000269
fast: false
is: SBO:0000185

metaR EX c4crn
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaR r0614
reactant: MODEL1310110013#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
reversible: true
is: SBO:0000176
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
kinetic law: MODEL1310110013#

metaM f1a g
boundary condition: false
initial amount: NaN
has only substance units: false
name: F1alpha
initial concentration: 1.0
type: Species
is: CHEBI:15936
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false

metaM ksi deg10 l
is: SBO:0000247
is: CHEBI:57455
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
initial concentration: 1.0
name: keratan sulfate I, degradation product 10
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01354
type: Species

metaR r1453
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is: SBO:0000176
fast: false
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR SBTD D2
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: D-sorbitol dehydrogenase (D-fructose producing)
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.14
kinetic law: MODEL1310110013#

metaR r0400
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
fast: false
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.4.4
modifier: MODEL1310110013#
is: SBO:0000176
type: Reaction

metaR P45011A1m
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.15.6
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (1583.1) SUBSYSTEM: Steroid metabolism EC Number: 1.14.15.67 Confidence Level: 4 AUTHORS: PMID:16232916 NOTES:reaction sequence mx steps, grouped into single reaction uses adrenal ferredoxin NJ
name: Cytochrome P450 11A1, mitochondrial [Precursor]
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_0f69003f_89cb_4041_ab47_8af64f6a2bc3
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:2629
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: GBA
is: B7Z6S1

metaM 3hexdtricoa m
type: Species
boundary condition: false
initial amount: NaN
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: HMDB02288
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_55e6468f_3d97_4dc1_a021_9a8788e87720
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000297
is encoded by: hsa:515
initial concentration: NaN
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
has only substance units: false

metaR METyLATthc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR DCSPTN1CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110013#
name: carnitine transferase
reactant: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM dece3coa x
type: Species
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
name: 3-decenoylcoa
is: SBO:0000247
constant: false
has only substance units: false

metaR r0839
name: Postulated transport reaction
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.70
type: Reaction
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:

metaR r0512
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
kinetic law: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_9ffc9a65_cd3e_46d3_a2e8_95de0f15445d
constant: false
boundary condition: true
type: Species
name: SLC25A2
initial amount: NaN
is: Q9BXI2
is encoded by: hsa:83884
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r1450
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110013#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000176
product: MODEL1310110013#
type: Reaction
name: EC:1.3.3.6

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaM CE2431 m
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
is: CHEBI:57795
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
name: cis-deca-4-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110013#_ee74f06a_8cc1_451f_b39a_dcbaa813f89a
is encoded by: hsa:51292
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: GMPR2
has only substance units: false
constant: false
is: Q9P2T1

metaM utp e
boundary condition: false
is: CHEBI:46398
initial amount: NaN
name: UTP(4-)
initial concentration: 1.0
is: HMDB00285
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_0102b24f_f025_4140_b88b_2c0d02e030ca
is encoded by: hsa:158
has only substance units: false
constant: false
initial amount: NaN
name: ADSL
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM mlthf c
is: SBO:0000247
name: 5,10-Methylenetetrahydrofolate
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial concentration: 1.0
constant: false
boundary condition: false
is: C00143
is: CHEBI:15636
has only substance units: false
is: HMDB01533
initial amount: NaN
type: Species

metaR r2119
reactant: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaR r0838
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
product: MODEL1310110013#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110013#
is described by: ECO:0000000
name: Free diffusion
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR DCSPTN1CPT1
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110013#
reversible: false
name: carnitine O-palmitoyltransferase

metaR DHFR
type: Reaction
fast: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
product: MODEL1310110013#
name: dihydrofolate reductase
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3

metaR PROSTGE2t
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110013#
reversible: true
fast: false
name: prostaglandin transport via bicarbonate countertransport
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_72163a20_0c82_4fb4_971f_75159d353abe
is encoded by: hsa:205
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is: P27144
initial concentration: NaN
name: AK4

http://identifiers.org/biomodels.db/MODEL1310110013#_428c05c3_f74c_48c6_8858_24d78708739d
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7296
is: Q16881
boundary condition: true
initial amount: NaN
name: TXNRD1
constant: false
initial concentration: NaN
type: Species

metaR NDP8
is version of: http://identifiers.org/ec-code/2.7.4.9
is described by: ECO:0000269
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
name: nucleoside-diphosphatase (dUDP)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_39ef6696_9846_4393_b8aa_785b4daba3db
initial concentration: NaN
constant: false
is encoded by: hsa:7167
boundary condition: true
name: TPI1
is: Q53HE2
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR EX dad 2 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 2-deoxyadenosine
type: Reaction

metaR EX debrisoquine LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: debrisoquine exchange
type: Reaction

metaR r2110
is described by: ECO:0000000
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaR CHOLtg
product: MODEL1310110013#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
name: choline intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110013#_cf1224b7_7c9f_4726_9571_a50990e4684b
is: B4DZR2
name: ALDH1A2
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:8854
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaR FAOXC184m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR LEUTA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
reactant: MODEL1310110013#
reversible: true
name: leucine transaminase
is: SBO:0000176
modifier: MODEL1310110013#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#

metaR r0724
fast: false
modifier: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110013#
type: Reaction
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33

metaR C161CRNt
product: MODEL1310110013#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#
name: C161 transport into the mitochondria
modifier: MODEL1310110013#
reversible: false
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
type: Reaction

metaM trdrd m
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
initial concentration: 1.0
has only substance units: false
is: CHEBI:15967
name: Reduced thioredoxin
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247

metaM ksi deg30 l
type: Species
name: keratan sulfate I, degradation product 30
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: HMDB00143
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
boundary condition: false
is: CHEBI:12936

metaR AFLATOXINte
name: xenobiotic transport
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ
fast: false
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
type: Reaction

metaM HC01405 m
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
is: CHEBI:28632
name: (S)-Hydroxyoctanoyl-CoA
initial amount: NaN
initial concentration: 1.0
constant: false

metaM chol c
is: HMDB00097
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
is: C00114
boundary condition: false
initial amount: NaN
constant: false
name: Choline
type: Species
is: CHEBI:15354
initial concentration: 1.0

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_74357fd0_3abc_444e_84ea_98f95b4b0016
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:205
initial amount: NaN
has only substance units: false
name: AK4
is: SBO:0000252
type: Species

metaM 5mta e
initial concentration: 1.0
type: Species
boundary condition: false
name: 5-Methylthioadenosine
is: SBO:0000247
is: C00170
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:17509
notes: FORMULA: C11H15N5O3S CHARGE: 0
is: HMDB01173

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR r0723
is: SBO:0000176
reversible: false
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
fast: false

metaR PE HSter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: phosphatidylethanolamine scramblase
reactant: MODEL1310110013#
reversible: true
product: MODEL1310110013#

metaM sprm c
name: spermine(4+)
is: CHEBI:45725
constant: false
initial amount: NaN
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
type: Species
has only substance units: false
is: HMDB01256
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r2535
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_a52875c9_555c_4971_86c9_a83fe3d4777a
is: O00483
initial concentration: NaN
is encoded by: hsa:4697
name: NDUFA4
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_7acb0c2d_6678_4e02_9815_b11559c11e66
is: SBO:0000252
has only substance units: false
name: _22305_1_c
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:22305
constant: false
initial concentration: NaN

metaM CE5854 e
initial concentration: 1.0
is: HMDB02710
initial amount: NaN
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
name: gama-CEHC-glucuronide
is: CHEBI:27485
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false

metaR AICART
modifier: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.3
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_34de7f86_320b_40fd_bc9e_31441d5b10df
boundary condition: true
type: Species
is encoded by: hsa:6509
initial amount: NaN
is: P43007
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC1A4

http://identifiers.org/biomodels.db/MODEL1310110013#_87e95626_dfd9_4bb8_a41c_85f7d450aaa4
constant: false
has only substance units: false
is: SBO:0000252
name: ECHS1
is: P30084
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1892
boundary condition: true
type: Species

metaR 3DSPHR
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
name: 3-Dehydrosphinganine reductase
is: SBO:0000176
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.102
reversible: false
fast: false
product: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:

metaM xylt c
is: HMDB02917
name: xylitol
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
is: CHEBI:17151
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaM 2pg c
name: D-Glycerate 2-phosphate
is: SBO:0000247
constant: false
is: CHEBI:58289
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: 1/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1/f/h5,7-8H HEPATONET_1.0_ABBREVIATION: HC00463 EHMN_ABBREVIATION: C00631
is: http://identifiers.org/pubchem.compound/3904
initial amount: NaN
is: HMDB03391
type: Species
boundary condition: false
is: C00631

http://identifiers.org/biomodels.db/MODEL1310110013#_483a221f_2a36_468d_9f4a_46a82fcefbd7
is: C9JZ62
initial concentration: NaN
name: TMEM91
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:641649
boundary condition: true
constant: false

metaM cdpdag hs c
name: CDP-diacylglycerol(2-)
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
boundary condition: false
constant: false
type: Species
is: CHEBI:58332
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR r2538
reversible: true
fast: false
kinetic law: MODEL1310110013#
name: Utilized transport
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM 2mop m
boundary condition: false
name: 2-methyl-3-oxopropanoate
type: Species
is: CHEBI:57700
has only substance units: false
initial concentration: 1.0
is: HMDB01172
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
constant: false

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaR r0722
type: Reaction
reactant: MODEL1310110013#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.3.12
is: SBO:0000176
kinetic law: MODEL1310110013#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
product: MODEL1310110013#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
modifier: MODEL1310110013#

metaM acgam c
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: N-acetyl-D-glucosamine
initial amount: NaN
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
is: CHEBI:17411
is: SBO:0000247
type: Species

metaR APOC LYS BTNPm
product: MODEL1310110013#
name: proteolysis of apoC-Lys-btn, mitochondrial
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110013#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM chol e
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: CHEBI:15354
name: Choline
is: SBO:0000247
initial concentration: 1.0
is: HMDB00097

metaR ARABR
name: arabinose reductase
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000269
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.21
reactant: MODEL1310110013#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_ccef369f_692c_43f1_b17c_d91de63dca8a
is: E7ET32
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2592
name: GALT
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_a8157859_5cd5_447f_a0e4_bb2f0a23e755
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: O00754
name: MAN2B1
initial concentration: NaN
is encoded by: hsa:4125
constant: false

metaR OCDCEAtr
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
reversible: true

metaR r2537
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110013#
name: Utilized transport
is described by: ECO:0000000

metaM etfrd m
is: C00631
is: http://identifiers.org/pubchem.compound/3904
is: SBO:0000247
is: CHEBI:58289
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: RH2 CHARGE: 0
name: Electron transfer flavoprotein reduced
is: HMDB03391
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_6299f9a7_f310_4b7b_b5ff_7679613a4595
is: SBO:0000252
initial concentration: NaN
is: O43426
name: SYNJ1
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:8867

metaR FAS160COA
reactant: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
fast: false
name: fatty-acyl-CoA synthase (n-C16:0CoA)
type: Reaction
product: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_3785dc2b_acec_4257_8b36_6bc5a02e71d0
initial amount: NaN
type: Species
has only substance units: false
name: NAGA
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4668
boundary condition: true
is: P17050

metaR r2114
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000000
type: Reaction

metaR LDH L
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110013#
type: Reaction
name: L-lactate dehydrogenase
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
fast: false
reactant: MODEL1310110013#
reversible: true

metaR r0946
is described by: ECO:0000000
product: MODEL1310110013#
reversible: true
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reactant: MODEL1310110013#

metaR r0720
is described by: ECO:0000000
reactant: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reversible: false
type: Reaction
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110013#_dfe51949_533e_4edd_846c_c4babe4b85be
boundary condition: true
has only substance units: false
name: HPGDS
is encoded by: hsa:27306
initial concentration: NaN
is: O60760
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaM thf c
constant: false
is: C00101
is: HMDB01846
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: CHEBI:57453
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247

metaM glu5p m
type: Species
has only substance units: false
name: L-Glutamate 5-phosphate
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
initial concentration: 1.0
is: HMDB01228
initial amount: NaN
is: CHEBI:58274

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_f6d0869a_71c7_4f5d_84b7_72ea1e5f1c42
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
name: LDHAL6B
is: SBO:0000252
is encoded by: hsa:92483
is: Q9BYZ2

metaR NACHEX1ly
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal

metaR r2113
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110013#

metaM mlthf m
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
is: SBO:0000247
initial amount: NaN
is: C00143
is: HMDB01533
type: Species

metaR KHK
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.3
kinetic law: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
name: ketohexokinase
reversible: false
product: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
fast: false

metaR FAOXC200180m
is described by: ECO:0000000
fast: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110013#

metaR GLYCTDle
is: SBO:0000185
is described by: ECO:0000134
name: difussion of glycerol accross the brush border membrane
type: Reaction
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_d2610b12_b8f0_40c8_86a3_95ad5172ea2c
is: SBO:0000252
is encoded by: hsa:1375
initial concentration: NaN
boundary condition: true
name: CPT1B
initial amount: NaN
type: Species
constant: false
is: Q92523
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_8e8079ca_23d3_4bd5_bd99_a845573011d5
initial amount: NaN
is encoded by: hsa:54511
boundary condition: true
initial concentration: NaN
is: Q9NT06
name: HMGCLL1
type: Species
constant: false
is: SBO:0000252
has only substance units: false

metaR r0408
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is version of: http://identifiers.org/ec-code/1.4.3.5
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
reversible: true
product: MODEL1310110013#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_a9391d8b_5ed2_4457_9c3b_b10536baabd4
boundary condition: true
type: Species
name: HMGCS2
is: P54868
is: SBO:0000252
is encoded by: hsa:3158
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaR APOC LYS BTNP
name: proteolysis of apoC-Lys-btn
kinetic law: MODEL1310110013#
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110013#
type: Reaction
reversible: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_437bee31_241d_434e_8c7a_751a9aaf84d7
type: Species
is encoded by: hsa:123041
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC24A4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_c426087c_f74e_460e_89cb_9c00748ed2db
name: FDFT1
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:2222
is: P37268
initial amount: NaN

metaR r2112
reactant: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000185

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM thf e
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: SBO:0000247
constant: false
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
is: HMDB01846
initial concentration: 1.0
is: CHEBI:57453
type: Species

metaR r0944
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
name: Active transport
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_1fc8ac1c_7002_4118_884d_35924243b53a
name: ST3GAL5
type: Species
is encoded by: hsa:8869
initial concentration: NaN
has only substance units: false
is: Q9UNP4
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR r0407
kinetic law: MODEL1310110013#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_0a5390e2_59d2_467c_883d_8ee0ed5aba43
name: ENPP1
type: Species
is: P22413
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:5167

metaM leuktrC4 e
has only substance units: false
initial concentration: 1.0
is: CHEBI:57973
boundary condition: false
name: leukotriene C4(2-)
initial amount: NaN
type: Species
is: HMDB01198
is: SBO:0000247
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_eb682fb4_b8e6_49fb_a10a_4416b74c702e
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: PDE9A
is encoded by: hsa:5152

metaM 7dhf e
has only substance units: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB06559
constant: false
name: heptaglutamyl folate (DHF)

http://identifiers.org/biomodels.db/MODEL1310110013#_bdd7a9e2_4855_438c_8bbe_fd7716958d73
initial amount: NaN
has only substance units: false
name: NOS1
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4842
is: SBO:0000252
boundary condition: true
is: B4DG68

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR r2111
fast: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#

MODEL1310110013
reaction: metaR UMPK4
reaction: metaR ALCD21 D
species: metaM glcur e
reaction: metaR EX dhf LPAREN e RPAREN
species: metaM lys L e
species: metaM 5oxpro e
reaction: metaR r1554
reaction: metaR P45027A1m
reaction: metaR S6TASE22ly
species: metaM ethamp c
species: metaM rib D e
species: metaM HC02121 c
reaction: metaR S6TASE13ly
reaction: metaR LNLCCPT2
species: metaM c12dccoa x
species: metaM oxa m
species: metaM apoC c
reaction: metaR r1655
species: metaM HC02214 e
reaction: metaR GLYSARPEPT1tc
reaction: metaR ACNACNGALGBSIDEtg
species: metaM dump c
reaction: metaR r2105
reaction: metaR DNDPt15m
species: metaM 5mta c
reaction: metaR URIt4
reaction: metaR r2352
reaction: metaR S6TASE18ly
species: metaM glyc R m
reaction: metaR r1949
species: metaM pchol hs c
species: metaM h2o g
reaction: metaR CORE6GTg
species: metaM 5adtststerones e
species: metaM k c
species: metaM ksi deg9 l
species: metaM cdp m
species: metaM nadh r
reaction: metaR LINKDEG4ly
species: metaM arachdcoa r
species: metaM ksii core4 l
species: metaM hdd2coa x
reaction: metaR EX pectindchac LPAREN e RPAREN
reaction: metaR RE1709N
reaction: metaR DAGK hs
species: metaM HC01409 m
reaction: metaR r1618
species: metaM 5adtststerones c
reaction: metaR LNLNCAt
species: metaM hpdcacoa m
reaction: metaR TMNDNCt
reaction: metaR CYTK12n
reaction: metaR RE0452M
reaction: metaR TALA
reaction: metaR MGCHrm
reaction: metaR r2333
species: metaM leuktrE4 c
species: metaM 1p3h5c c
reaction: metaR FAOXC183803m
reaction: metaR S6TASE17ly
reaction: metaR FAOXC142C122m
reaction: metaR r1560
species: metaM chsterol r
reaction: metaR LNLNCACPT1
reaction: metaR PAFt
species: metaM icit m
species: metaM ksi deg26 l
species: metaM 2dodtricoa m
reaction: metaR BILIRUBtr
reaction: metaR EX so4 LPAREN e RPAREN
reaction: metaR Q10H2e
species: metaM datp n
species: metaM bhb m
species: metaM CE2418 m
reaction: metaR SIAASE3ly
reaction: metaR r2473
reaction: metaR G5SADrm
species: metaM hpdcacrn m
reaction: metaR r2377
species: metaM od2coa c

http://identifiers.org/biomodels.db/MODEL1310110013#_f9423164_c21c_47a6_a5dc_b7dc184f35eb
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:522
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
has part: Q6NZ59
is: SBO:0000297

metaM sprm e
name: spermine(4+)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:45725
is: HMDB01256
notes: FORMULA: C10H30N4 CHARGE: 4 INCHI: InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2 HEPATONET_1.0_ABBREVIATION: HC00525 EHMN_ABBREVIATION: C00750
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_c7431292_27b2_439a_96b0_321a8c53fda1
is encoded by: hsa:23761
is: Q9UG56
constant: false
boundary condition: true
name: PISD
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM 5mta c
constant: false
name: 5-Methylthioadenosine
is: HMDB01173
boundary condition: false
is: C00170
is: CHEBI:17509
notes: FORMULA: C11H15N5O3S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00165 EHMN_ABBREVIATION: C00170
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species

metaR FAOXC201C181x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaR PAFH
fast: false
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.47
name: Platelet-activating factor acetylhydrolase
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_7bbe4ee0_126c_40d8_b6e3_6093c2bb040e
initial concentration: NaN
boundary condition: true
is: P30838
is: SBO:0000252
initial amount: NaN
name: ALDH3A1
constant: false
type: Species
is encoded by: hsa:218
has only substance units: false

metaM mev R c
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: (R)-mevalonate
initial amount: NaN
is: CHEBI:36464
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: HMDB00227
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_0d66f5e7_b1e7_40ea_a19b_cfe6f4aa4afd
type: Species
constant: false
name: SULT1A1
boundary condition: true
is: P50225
initial amount: NaN
has only substance units: false
is encoded by: hsa:6817
is: SBO:0000252
initial concentration: NaN

metaR FAOXC225C204x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

metaR r1914
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: false
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM hmgcoa c
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01375
constant: false
is: CHEBI:15467
boundary condition: false
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356

metaR LPS4e
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.4
product: MODEL1310110013#
reversible: false
name: phospholipase
type: Reaction

metaM datp n
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: HMDB01532
is: C00131
name: dATP
initial concentration: 1.0
is: CHEBI:61404
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial amount: NaN

metaR FMNAT
kinetic law: MODEL1310110013#
fast: false
name: FMN adenylyltransferase
reactant: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
modifier: MODEL1310110013#
is described by: ECO:0000134
reversible: false
type: Reaction
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.7.2

metaR OXAHCOtex
reversible: false
fast: false
product: MODEL1310110013#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110013#
name: oxalate transport via bicarbonate countertransport
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110013#

metaR r2140
reactant: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

metaM ksi deg11 l
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247
is: HMDB00143
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
type: Species
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 11

metaR S6TASE23ly
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
type: Reaction
product: MODEL1310110013#
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR r1913
fast: false
product: MODEL1310110013#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM crn r
is: HMDB00062
name: (R)-carnitine
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
boundary condition: false
is: CHEBI:16347

http://identifiers.org/biomodels.db/MODEL1310110013#_884cd71c_b3b1_475b_82de_4402d1c2c64f
constant: false
type: Species
is: SBO:0000252
name: AMACR
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23600
has only substance units: false
is: Q9UHK6

http://identifiers.org/biomodels.db/MODEL1310110013#_cc17c94d_f843_479f_bfa4_3d606df924e9
name: PDE6C
initial amount: NaN
is encoded by: hsa:5146
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is: P51160
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_65c94afc_a117_4fd6_a17c_249501c725ec
name: KHK
is encoded by: hsa:3795
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q6IBK2
initial amount: NaN
is: SBO:0000252

metaM retinal cis 13 r
initial amount: NaN
name: 13-cis-retinal
type: Species
is: CHEBI:45487
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: HMDB06220
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM datp m
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
name: dATP
is: HMDB01532
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:61404
constant: false
is: C00131

metaR r0086
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
is: SBO:0000176
modifier: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.3
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM dctp n
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16311
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
constant: false
is: HMDB00998
name: dCTP

metaM retinol c
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00305
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: SBO:0000247
type: Species
is: CHEBI:50211
initial concentration: 1.0
boundary condition: false
name: retinol

metaR r2141
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
fast: false

metaR THRGLNexR
fast: false
reactant: MODEL1310110013#
name: L-threonine/glycine reversible exchange
is described by: ECO:0000304
reversible: true
modifier: MODEL1310110013#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR FAOXC16080m
reversible: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110013#
name: Beta oxidation of long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110013#_10677096_0a97_46a0_a147_7232ca8826d6
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P48426
initial concentration: NaN
boundary condition: true
name: PIP4K2A
is encoded by: hsa:5305
constant: false

metaM CE2839 e
name: maltodecaose
type: Species
constant: false
is: C01936
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: SBO:0000247

metaR r1912
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reversible: false
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110013#

metaM Rtotal3 c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16189
initial amount: NaN
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: HMDB01448
type: Species
is: SBO:0000247
constant: false
name: R total 3 position

metaR r0973
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_50e6203c_d0c2_4d6b_8f5a_19eefa812d95
type: Species
name: COX7B2
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:170712
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q8TF08

metaR DRBK
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
name: Deoxyribokinase
is: SBO:0000176
reversible: false
modifier: MODEL1310110013#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.15
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_4beaf330_0934_4703_bc9c_d016a3683bd2
has only substance units: false
is encoded by: hsa:28976
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: Q9H845
name: ACAD9

metaR ETOHt
is: SBO:0000185
reversible: true
product: MODEL1310110013#
is described by: ECO:0000000
name: ethanol reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110013#
type: Reaction
fast: false
reactant: MODEL1310110013#

metaR r2142
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
product: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_d6b28c44_b108_4a93_95a3_d50d413af9bb
boundary condition: true
constant: false
is: Q9H2F3
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: HSD3B7
type: Species
is encoded by: hsa:80270
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_671565df_d575_450f_953c_090484988041
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q12882
boundary condition: true
name: DPYD
type: Species
constant: false
is encoded by: hsa:1806
initial concentration: NaN

metaR r1911
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
reversible: false
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaM pan4p c
name: Pantetheine 4'-phosphate
initial concentration: 1.0
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN
is: CHEBI:47942
is: SBO:0000247
type: Species
has only substance units: false
is: C01134
boundary condition: false
is: HMDB01416
constant: false

metaR CBASPte
is: SBO:0000185
kinetic law: MODEL1310110013#
name: Transport of N-carbamoyl-L-aspartate
fast: false
reversible: true
is described by: ECO:0000134
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM c226crn c
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
name: cervonyl carnitine
type: Species
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB06510
initial amount: NaN
is: http://identifiers.org/pubchem.compound/127055
boundary condition: false
initial concentration: 1.0

metaR r0974
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110013#
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
reversible: true
kinetic law: MODEL1310110013#

metaM mi13p c
has only substance units: false
constant: false
is: CHEBI:18225
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB06234
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
type: Species
initial amount: NaN
name: 1D-myo-Inositol 1,3-bisphosphate

metaM ksi deg9 l
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB00143
initial amount: NaN
notes: FORMULA: C188H301N13O166S10 CHARGE: -10
is: SBO:0000247
is: CHEBI:12936
constant: false
name: keratan sulfate I, degradation product 9

http://identifiers.org/biomodels.db/MODEL1310110013#_8601b34e_e2b5_4d23_9fe5_ba4a14553e28
constant: false
name: SLC25A21
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:89874
is: G3V4L5

metaM pail hs n
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57880
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)

http://identifiers.org/biomodels.db/MODEL1310110013#_23eb0318_56a4_4a37_ac53_12e034df65ee
boundary condition: true
constant: false
is: P00352
is encoded by: hsa:216
has only substance units: false
type: Species
is: SBO:0000252
name: ALDH1A1
initial concentration: NaN
initial amount: NaN

metaM dcmp n
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
name: dCMP(2-)
is: CHEBI:57566
is: HMDB01202
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaR URIt
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
modifier: MODEL1310110013#
name: uridine facilated transport in cytosol
fast: false
product: MODEL1310110013#

metaM itaccoa m
initial amount: NaN
is: SBO:0000247
constant: false
name: itaconyl-CoA(5-)
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: CHEBI:57381
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB03377

metaR H2Otly
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110013#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
name: H2O transport, lysosomal

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

metaR r1918
is: SBO:0000185
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000

metaM gtp c
is: SBO:0000247
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
name: GTP
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: C00044
constant: false
initial concentration: 1.0

metaM ach n
is: CHEBI:15355
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
type: Species
name: acetylcholine
boundary condition: false
is: HMDB00895
initial amount: NaN

metaM Rtotal3 e
initial amount: NaN
name: R total 3 position
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:3554
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: SBO:0000247
is: C00255
is: HMDB00244

metaR r1568
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM biocyt c
is: SBO:0000247
is: HMDB03134
initial concentration: 1.0
is: C05552
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
constant: false
name: Biocytin
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species
initial amount: NaN
boundary condition: false

metaM xol7ah3 c
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: HMDB12455
is: SBO:0000247
is: CHEBI:28540
constant: false
initial concentration: 1.0

metaR RE3006M
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110013#
name: RE3006

metaR GLCAASE7ly
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
modifier: MODEL1310110013#

metaR FAOXC164C143x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaR r1917
reversible: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#

metaM pan4p e
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2
name: Pantetheine 4'-phosphate
is: CHEBI:47942
is: SBO:0000247
initial concentration: 1.0
is: C01134
constant: false
has only substance units: false
is: HMDB01416

metaR r1567
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: true
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_25ca7295_6881_4830_b650_dda3f33efc37
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: P00558
constant: false
name: PGK1
is encoded by: hsa:5230
initial amount: NaN

metaR BILIRUBtr
is: SBO:0000185
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110013#
fast: false
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_00a4e02d_1a7c_403a_8f3c_000b3ac908df
has only substance units: false
is: Q5TDP6
boundary condition: true
is: SBO:0000252
name: LGSN
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:51557
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_1112392a_5ef2_4e2c_8565_e5b83f60b943
name: ATP5A1
type: Species
is: B4DY56
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:498
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_fb61e62e_7443_405e_a806_4150a9ba13f9
is encoded by: hsa:F23536
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: _F23536_1_m
boundary condition: true
initial amount: NaN

metaR r1916
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
modifier: MODEL1310110013#
name: Y+LAT2 Utilized transport
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_08a2ef87_19b7_4002_9c92_1b06f125a931
is encoded by: hsa:3000
name: GUCY2D
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q02846
type: Species
initial concentration: NaN

metaR CYTK8n
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110013#
name: cytidylate kinase (CMP,dATP),nuclear
fast: false
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_e5755938_2d8e_48dd_a5b4_88510f749cb2
boundary condition: true
is: O95169
name: NDUFB8
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:4714

metaM biocyt e
boundary condition: false
is: C05552
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
name: Biocytin
initial amount: NaN
type: Species
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: SBO:0000247
is: HMDB03134

metaR CYTDt
fast: false
name: cytidine facilated transport in cytosol
product: MODEL1310110013#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110013#_2f3bb907_214a_4b50_a2f9_6b6980b1a876
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10861
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC26A1

http://identifiers.org/biomodels.db/MODEL1310110013#_a1d98555_3dc3_4f54_82f7_016baf215de9
name: PIGQ
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9BRB3
is encoded by: hsa:9091

metaR FAOXC142C122x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_9f5bc88a_cd6b_4da9_993d_e2c9762c8a6f
is: B7Z6S1
boundary condition: true
is encoded by: hsa:2629
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: GBA

metaM dece3coa m
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
has only substance units: false
type: Species
name: 3-decenoylcoa

metaR 34HPPOR
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110013#
fast: false
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.27
reversible: false
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_d5227205_775e_4389_91f9_b80b55ec47b1
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: ATP5D
type: Species
boundary condition: true
is encoded by: hsa:513
initial concentration: NaN

metaM Lcyst c
constant: false
is: CHEBI:58090
notes: FORMULA: C3H6NO5S CHARGE: -1 INCHI: InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9)/p-1/t2-/m0/s1 EHMN_ABBREVIATION: C00506
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: L-cysteate(1-)
is: HMDB02757
type: Species

metaM hexdicoa r
is: C08260
name: hexadecanedioylcoa
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: HMDB00672
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR r1569
kinetic law: MODEL1310110013#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110013#
product: MODEL1310110013#

metaR r1459
name: Transport reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:

metaM Lkynr c
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
boundary condition: false
constant: false
type: Species
is: HMDB00684
initial concentration: 1.0
name: L-kynurenine
is: CHEBI:16946
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_a099fc01_4ef9_4ef7_8eac_37246610651d
initial concentration: NaN
is: P07205
is encoded by: hsa:5232
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: PGK2
has only substance units: false
initial amount: NaN

metaR GLCURter
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110013#
name: glucuronate endoplasmic reticular transport
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110013#_3a1a0e20_e001_4fb5_add3_03ae0c524469
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: P80404
name: ABAT
is encoded by: hsa:18

metaM 4hoxpacd c
type: Species
is: HMDB03767
has only substance units: false
name: (4-hydroxyphenyl)acetaldehyde
initial concentration: 1.0
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
initial amount: NaN
boundary condition: false
is: CHEBI:15621
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_a8b836d6_005e_4871_bd36_74f93668a314
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6550
constant: false
is: P48764
type: Species
name: SLC9A3
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR RE2973C
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.137
is: SBO:0000176
fast: false
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.1.153
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_c38412ac_561a_4801_891f_20c213807f08
initial concentration: NaN
initial amount: NaN
type: Species
is: P48201
constant: false
name: ATP5G3
is: SBO:0000252
is encoded by: hsa:518
has only substance units: false
boundary condition: true

metaR MI14PP
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.57
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
name: inositol-1,4-bisphosphate 1-phosphatase
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
reversible: false
product: MODEL1310110013#

metaR FAOXC205C184x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_71bb24da_a089_4710_bba8_5c76946469c4
is: P48448
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:222
name: ALDH3B2
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_c16ec7fd_dd48_4ca5_8f80_094566314585
is encoded by: hsa:11112
type: Species
is: P31937
initial amount: NaN
name: HIBADH
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaR DURItn
reversible: true
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110013#
fast: false
is described by: ECO:0000000
name: deoxyuridine transport in nucleus
reactant: MODEL1310110013#

metaM dcmp c
has only substance units: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57566
is: C00239
is: HMDB01202
is: SBO:0000247
name: dCMP

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR PYAM5POr
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
type: Reaction
product: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000269
name: pyridoxamine 5'-phosphate oxidase
reactant: MODEL1310110013#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110013#_fc30f82d_4f92_418a_9364_d26ebcf40149
boundary condition: true
is: SBO:0000252
name: NDUFA1
has only substance units: false
is: Q6IBB5
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:4694

http://identifiers.org/biomodels.db/MODEL1310110013#_ee0d4198_baf4_4173_99b2_a5d887b36212
is encoded by: hsa:2588
has part: Q99519
is encoded by: hsa:2720
is encoded by: hsa:5476
initial amount: NaN
name: GALNS:GLB1:NEU1:CTSA
initial concentration: NaN
has only substance units: false
is: SBO:0000297
constant: false
is encoded by: hsa:4758
type: Species
boundary condition: true
has part: P10619
has part: P34059
has part: P16278

metaM gtp e
is: HMDB01273
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: GTP(4-)
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
constant: false
initial amount: NaN

metaM clpndcoa c
is: http://identifiers.org/pubchem.compound/47205476
boundary condition: false
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
name: clupanodonyl CoA
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB06267
is: C16166
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_130e536b_98af_4d90_9605_3b81d85e72e0
name: NDUFA6
boundary condition: true
is: P56556
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:4700
type: Species

metaR UMPK6n
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dCTP),nuclear
product: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_7a86f5ac_a372_4206_a530_8b1603770899
is encoded by: hsa:AI378339
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: _AI378339_1_m

http://identifiers.org/biomodels.db/MODEL1310110013#_b32991b7_803c_40c3_a52c_ea76034d48c2
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SUCLA2
is: E5KS60
is: SBO:0000252
is encoded by: hsa:8803
type: Species
constant: false

metaR CSPG Btly
type: Reaction
reversible: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
name: chondroitin sulfate B transport, extracellular to lysosome

metaM clpnd e
boundary condition: false
initial amount: NaN
is: CHEBI:53488
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB06528
name: clupanodonic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-

metaM lnlc r
name: linoleate
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: HMDB00673
boundary condition: false
has only substance units: false
is: CHEBI:30245
initial amount: NaN
constant: false

metaM HC00342 c
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false
name: cis-aconitate(3-)
initial concentration: 1.0
is: CHEBI:16383
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_6651bfaa_bfbb_4268_a11e_195a03f73bec
is: Q7Z364
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: PDE1B
initial amount: NaN
boundary condition: true
is encoded by: hsa:5153

http://identifiers.org/biomodels.db/MODEL1310110013#_f8887866_0a64_43af_aed6_d1cfd63cc015
name: PDE8A
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5151
constant: false
type: Species
initial concentration: NaN

metaM phe L c
is: CHEBI:17295
boundary condition: false
initial amount: NaN
name: L-phenylalanine
is: SBO:0000247
is: HMDB00159
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial concentration: 1.0
constant: false
has only substance units: false

metaM 2dodtricoa m
constant: false
is: C05279
type: Species
has only substance units: false
name: 2,6,9-dodecatrienoylcoa
initial amount: NaN
initial concentration: 1.0
is: HMDB11123
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

metaM crn x
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: L-Carnitine
initial concentration: 1.0
is: SBO:0000247
is: C00318
is: CHEBI:16347
is: HMDB00062
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR r0821
modifier: MODEL1310110013#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110013#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_5c6c9030_b49b_495a_ae9a_22a06d705654
initial amount: NaN
name: DGKI
type: Species
boundary condition: true
constant: false
is: O75912
is encoded by: hsa:9162
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR GGH 7DHFe
is: SBO:0000176
name: Gamma-glutamyl hydrolase (7DHF), extracellular
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110013#
reversible: false
type: Reaction
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false

metaR ACACt2m
reactant: MODEL1310110013#
name: Acetoacetate mitochondrial transport via H+ symport
type: Reaction
is: SBO:0000185
product: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reversible: true
is described by: ECO:0000269
fast: false

metaM hs l
initial concentration: 1.0
constant: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
has only substance units: false
type: Species
is: CHEBI:28815
name: heparan sulfate, free chain
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM 3otdcoa m
is: CHEBI:28726
is: SBO:0000247
boundary condition: false
is: HMDB03935
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
name: 3-Oxotetradecanoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_0f2ba0bd_28db_4809_bd5f_bffee58b7d36
is encoded by: hsa:285973
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q674R7
has only substance units: false
name: ATG9B
initial concentration: NaN
constant: false
type: Species

metaR FAOXC142C122m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaM acmanap c
name: N-acetyl-D-mannosamine 6-phosphate(2-)
is: HMDB01121
has only substance units: false
initial amount: NaN
is: CHEBI:58557
type: Species
boundary condition: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM ocdca c
boundary condition: false
initial amount: NaN
is: CHEBI:25629
type: Species
is: HMDB00827
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: SBO:0000247
initial concentration: 1.0
name: stearate
constant: false

metaR r0604
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is: SBO:0000176
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is described by: ECO:0000000

metaM urcan c
initial concentration: 1.0
name: Urocanate
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
has only substance units: false
is: CHEBI:17771
is: HMDB00301
is: SBO:0000247
is: C00785

http://identifiers.org/biomodels.db/MODEL1310110013#_34a192a9_f66b_4f7b_a78f_3d01994f37f6
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5092
initial concentration: NaN
type: Species
is: P61457
has only substance units: false
name: PCBD1

http://identifiers.org/biomodels.db/MODEL1310110013#_4365538b_37b1_479d_8700_1f78b200fee0
name: NME2
initial amount: NaN
is: P22392
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4831
constant: false
has only substance units: false
boundary condition: true
type: Species

metaR NTP3e
is: SBO:0000176
kinetic law: MODEL1310110013#
is described by: ECO:0000269
modifier: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
reversible: false
name: nucleoside-triphosphatase (GTP)
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_7e0d3692_f79d_4a27_b2b1_f5a7fea1006a
has only substance units: false
boundary condition: true
type: Species
is: Q06830
is encoded by: hsa:5052
name: PRDX1
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_4f88953f_b0e8_41f8_b646_a42e8bc3b910
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:4719
constant: false
is: P28331
initial amount: NaN
name: NDUFS1
boundary condition: true

metaM prostgf2 c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57404
is: HMDB01139
name: prostaglandin F2alpha(1-)

metaR UMPK
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: UMP kinase
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: true
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110013#

metaR r1148
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
fast: false
name: Active transport
is: SBO:0000185
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_ab50a8b8_3518_443c_85bd_fdaa4a52e2fd
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P25705
type: Species
has only substance units: false
name: ATP5A1
constant: false
is encoded by: hsa:498

metaR HPDCACRNCPT1
type: Reaction
reversible: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
reactant: MODEL1310110013#
product: MODEL1310110013#
name: carnitine fatty-acyl transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false

metaR RE2659R
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
name: RE2659
type: Reaction
reactant: MODEL1310110013#
fast: false

metaR CHOLt4
reversible: true
is: SBO:0000185
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
fast: false
name: choline, sodium cotransport
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#

metaM hexdicoa x
type: Species
is: SBO:0000247
initial concentration: 1.0
name: hexadecanedioylcoa
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: HMDB02288

metaR DM gncore2 g
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gncore2(g)
type: Reaction

metaM CE5117 m
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
boundary condition: false
has only substance units: false

metaM retinol 9 cis c
name: 9-cis-retinol
initial concentration: 1.0
is: CHEBI:17336
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial amount: NaN
boundary condition: false
is: HMDB06217
constant: false

metaM gtp m
is: SBO:0000247
is: HMDB01273
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C00044
is: CHEBI:37565
type: Species

metaR LEUKTRB4t
is described by: ECO:0000000
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
fast: false
name: leukotriene B4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110013#

metaR r1147
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#

metaM fadh2 c
boundary condition: false
constant: false
is: HMDB01197
initial amount: NaN
is: CHEBI:58307
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
has only substance units: false

metaM biocyt m
constant: false
is: SBO:0000247
has only substance units: false
name: Biocytin
initial amount: NaN
type: Species
is: HMDB03134
boundary condition: false
is: http://identifiers.org/pubchem.compound/7886
is: C05552
initial concentration: 1.0
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552

http://identifiers.org/biomodels.db/MODEL1310110013#_e6bca31d_094a_42b1_9e44_a29ac53e44e6
type: Species
constant: false
has only substance units: false
name: ATP5J
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:522
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_dba02ab0_da96_4ead_beae_7fe9f3c49037
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q14032
initial concentration: NaN
has only substance units: false
is encoded by: hsa:570
name: BAAT
type: Species
constant: false

metaR HPDCACRNCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
name: heptadecanoate transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_731d5e59_0551_42b3_9e89_36b82c07728f
has only substance units: false
initial amount: NaN
is: Q13956
name: PDE6H
constant: false
is encoded by: hsa:5149
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_12777069_a061_4e7a_8ddb_8bf341d4ba91
name: PMM1
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5372
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: A8K003

metaR DALAt2r
product: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
reversible: true
kinetic law: MODEL1310110013#
name: D-alanine transport via proton symport
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110013#
fast: false

metaM prostgf2 e
initial amount: NaN
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01139
is: CHEBI:57404
name: prostaglandin F2alpha(1-)

metaM ach c
has only substance units: false
is: CHEBI:15355
is: HMDB00895
name: acetylcholine
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996

metaM man l
is: HMDB00169
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:16024
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
constant: false
name: D-mannose

metaM biocyt n
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
is: HMDB03134
is: C05552
boundary condition: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species

metaM ach e
constant: false
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: acetylcholine
is: HMDB00895

metaR VALLAT1tc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_40f01f43_1368_4044_81e2_4a89d13bab16
is: SBO:0000252
has only substance units: false
name: ALPL
is: B7Z4Y6
is encoded by: hsa:249
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaM dgsn c
type: Species
boundary condition: false
initial concentration: 1.0
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: SBO:0000247
is: C00330
is: HMDB00085
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:17172

metaR SPH1Pte
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
name: sph1p transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ

metaM retinol 9 cis e
is: CHEBI:17336
initial concentration: 1.0
name: 9-cis-retinol
constant: false
boundary condition: false
initial amount: NaN
is: HMDB06217
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
type: Species
is: SBO:0000247
has only substance units: false

metaR r0196
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000176
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
type: Reaction
reversible: true

metaM rib D e
type: Species
is: CHEBI:16988
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
is: SBO:0000247
name: D-ribose
constant: false
initial amount: NaN
is: HMDB00283
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_e4e38eca_9b11_4424_a571_bd6de7727f45
initial amount: NaN
name: _AL050025_1_c
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AL050025
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_88e3dc4b_c60f_4ffa_b593_d163b90d90df
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:43
constant: false
initial concentration: NaN
boundary condition: true
name: ACHE

metaR RE1903R
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
type: Reaction
fast: false
name: RE1903
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_ebca21c5_403c_4c2e_8ab4_63887e3a819a
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:125965
initial amount: NaN
constant: false
boundary condition: true
name: COX6B2
has only substance units: false
is: Q6YFQ2

http://identifiers.org/biomodels.db/MODEL1310110013#_b499ee11_42e5_4133_8c15_00784ffd5da5
is: SBO:0000252
is encoded by: hsa:3141
constant: false
type: Species
has only substance units: false
name: HLCS
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P50747

metaM rib D c
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16988
name: D-ribose
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00283

metaM cala c
constant: false
is: SBO:0000247
name: N-carbamoyl-beta-alaninate
has only substance units: false
boundary condition: false
is: CHEBI:11892
initial amount: NaN
is: HMDB00026
initial concentration: 1.0
type: Species
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642

metaR r2104
modifier: MODEL1310110013#
reversible: true
is described by: ECO:0000000
product: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110013#
type: Reaction
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_8c70283b_214a_4750_843c_9a6930e6dbf4
initial concentration: NaN
name: PDE4D
is: SBO:0000252
is encoded by: hsa:5144
initial amount: NaN
has only substance units: false
is: Q08499
constant: false
type: Species
boundary condition: true

metaM btcoa x
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB01088
is: C00136
initial concentration: 1.0

metaR FAOXC2051843m
name: Beta oxidation of fatty acid
product: MODEL1310110013#
reversible: false
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110013#

metaR r0193
is described by: ECO:0000000
type: Reaction
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
is: SBO:0000176
reversible: true
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_b588c26b_da29_482a_b93e_45a9d034149f
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: P00491
is encoded by: hsa:4860
name: PNP
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_9c2d334f_c9dd_41d5_96ba_bc30e1fed081
type: Species
is: Q96RV2
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3038
initial amount: NaN
has only substance units: false
boundary condition: true
name: HAS3

http://identifiers.org/biomodels.db/MODEL1310110013#_4b10949d_d24c_45a4_94c6_74be9c2dd854
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1103
is: Q6LEN6
boundary condition: true
is: SBO:0000252
type: Species
name: CHAT
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_12e486b4_cd6c_4c82_83fd_21df4744fbfc
type: Species
is encoded by: hsa:8503
has part: A7E2E0
has only substance units: false
initial concentration: NaN
constant: false
name: PIK3CD:PIK3R3
is: SBO:0000297
boundary condition: true
is encoded by: hsa:5293
initial amount: NaN
has part: Q92569

metaM tdchola e
is: HMDB00951
boundary condition: false
name: taurochenodeoxycholate
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
type: Species
is: CHEBI:9407
initial amount: NaN

metaR r2103
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110013#
fast: false
product: MODEL1310110013#
modifier: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
is: SBO:0000185

metaM gdpfuc g
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57984
name: GDP-L-fucose(2-)
is: SBO:0000247
constant: false
is: HMDB01095

http://identifiers.org/biomodels.db/MODEL1310110013#_6766739e_8ce7_4d86_854c_11e79bd0da57
is: SBO:0000252
boundary condition: true
name: NDUFS6
initial amount: NaN
is: Q6IBC4
is encoded by: hsa:4726
has only substance units: false
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_f95e954e_ddd4_453e_8e99_733eec6cf8d8
has only substance units: false
boundary condition: true
has part: P38117
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2109
name: ETFA:ETFB
constant: false
is: SBO:0000297
type: Species

metaR r0523
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110013#
fast: false
type: Reaction
modifier: MODEL1310110013#

metaM tetpent6 e
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB06322
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
name: tetracosapentaenoic acid, n-6
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_5bdad6d3_10f7_46b4_a693_055fe360e4f3
constant: false
is: B2RBR4
initial concentration: NaN
type: Species
has only substance units: false
name: SLC20A2
boundary condition: true
is encoded by: hsa:6575
initial amount: NaN
is: SBO:0000252

metaR A MANASEly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
reversible: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
name: alpha-mannosidase, lysosomal
modifier: MODEL1310110013#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.24
type: Reaction
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_c60e832f_8dbe_4c2f_8d13_e30eecb513f1
boundary condition: true
constant: false
is encoded by: hsa:1119
name: CHKA
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM odecoa m
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57387
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Octadecenoyl-CoA (n-C18:1CoA)
type: Species
is: HMDB01322

http://identifiers.org/biomodels.db/MODEL1310110013#_d75eac31_0524_4440_869f_4eb26e07b933
is: Q9BY49
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:55825
type: Species
has only substance units: false
constant: false
name: PECR
boundary condition: true

metaR r2106
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
modifier: MODEL1310110013#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r1464
kinetic law: MODEL1310110013#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
name: Active transport
fast: false
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_431ed01b_5982_4709_acd2_d11f0682e7af
name: SGPP2
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:130367
type: Species
is: SBO:0000252
is: Q8IWX5

metaM gthrd e
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial amount: NaN
is: CHEBI:57925
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: glutathionate(1-)
constant: false
is: SBO:0000247
is: HMDB00125

metaM 3pg c
initial amount: NaN
is: SBO:0000247
is: CHEBI:58272
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: 3-Phospho-D-glycerate
boundary condition: false
is: C00197
is: http://identifiers.org/pubchem.compound/3497
is: HMDB00807

metaR r0829
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000185
modifier: MODEL1310110013#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.37
fast: false
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110013#

metaM dgdp n
is: HMDB00960
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:58595
name: dGDP(2-)
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
is: SBO:0000247

metaM h2o2 n
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
constant: false
is: HMDB03125
type: Species
name: hydrogen peroxide
is: CHEBI:16240

metaR r0603
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.12
reversible: true
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
product: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
type: Reaction

metaR SIAASE4ly
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_7ec270df_5732_4804_92d2_27673b25446d
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _AA614647_1_c
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AA614647

metaR VALt5m
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
name: Valine reversible mitochondrial transport
type: Reaction
reversible: true
reactant: MODEL1310110013#

metaR 10FTHFtm
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is: SBO:0000185
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000000
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
fast: false
kinetic law: MODEL1310110013#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_6c144f24_0cf2_43e0_aca1_8d43bcb3df64
name: PKM2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5315
constant: false
boundary condition: true
is: P14618
type: Species
initial amount: NaN

metaR GAL3ST11
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.11
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: Galactosylceramide sulfotransferase
kinetic law: MODEL1310110013#
fast: false
is: SBO:0000176
reversible: false

metaM tdchola c
initial amount: NaN
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00951
constant: false
name: taurochenodeoxycholate
is: CHEBI:9407

metaM gtp n
has only substance units: false
boundary condition: false
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
type: Species
name: GTP(4-)
is: HMDB01273
is: SBO:0000247
initial amount: NaN
constant: false

metaR r1570
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM hs deg1 l
has only substance units: false
is: HMDB06210
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
name: heparan sulfate, degradation product 1

http://identifiers.org/biomodels.db/MODEL1310110013#_ad13a114_d876_4fff_bb14_6d685b674869
has only substance units: false
initial concentration: NaN
name: PLCB3
is: SBO:0000252
type: Species
is encoded by: hsa:5331
initial amount: NaN
is: G5E960
boundary condition: true
constant: false

metaM ocdca e
initial concentration: 1.0
type: Species
is: HMDB00827
name: octadecanoate (n-C18:0)
has only substance units: false
is: CHEBI:25629
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: C01530
constant: false

metaR r2105
fast: false
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110013#
type: Reaction
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_409ebd0a_8615_4c48_87f7_341c622a8206
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:8309
initial amount: NaN
constant: false
boundary condition: true
name: ACOX2
is: Q99424

http://identifiers.org/biomodels.db/MODEL1310110013#_bd3a6f28_42df_4a53_b4ab_253fa8068eea
is: SBO:0000252
is encoded by: hsa:6489
initial amount: NaN
is: Q92185
name: ST8SIA1
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false

metaM dgdp m
name: dGDP(2-)
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:58595
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: HMDB00960
type: Species

metaM mthgxl c
name: methylglyoxal
is: CHEBI:17158
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB01167
initial concentration: 1.0
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
constant: false
has only substance units: false

metaR SPRMTDe
is: SBO:0000185
is described by: ECO:0000134
name: absorption for spermine across the basolateral side
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.
reactant: MODEL1310110013#
reversible: true
type: Reaction

metaR AHEXASEly
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
modifier: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_9e8c9c79_0b68_46b1_b744_d1ec4a403c0d
has only substance units: false
is encoded by: hsa:W87865
initial amount: NaN
initial concentration: NaN
name: _W87865_1_c
boundary condition: true
is: SBO:0000252
type: Species
constant: false

metaM gthrd c
type: Species
constant: false
is: C00051
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57925
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
is: HMDB00125
name: Reduced glutathione

http://identifiers.org/biomodels.db/MODEL1310110013#_5a1f7c46_d460_4896_8c93_7546b336b9f3
initial amount: NaN
is: P30837
is encoded by: hsa:219
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
name: ALDH1B1

metaM man c
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
initial amount: NaN
initial concentration: 1.0
is: C00159
is: SBO:0000247
is: CHEBI:16024
name: D-Mannose
boundary condition: false
is: HMDB00169
has only substance units: false
type: Species

metaR r1466
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110013#
name: EC:2.3.1.86

metaR r2108
reactant: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110013#
fast: false
type: Reaction
modifier: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110013#_d27ef89c_17f4_4a7e_bcf7_fd4a871a2533
has part: P50213
has part: E9PDD5
is encoded by: hsa:3420
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:3419
is encoded by: hsa:3421
is: SBO:0000297
name: IDH3A:IDH3B:IDH3G
boundary condition: true
initial concentration: NaN

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaR r0750
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
fast: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is: SBO:0000176
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_25a02021_f82a_4201_8e39_57253099398a
is encoded by: hsa:278
initial amount: NaN
constant: false
is: P04745
initial concentration: NaN
name: AMY1C
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM 3mox4hpac m
has only substance units: false
initial concentration: 1.0
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
is: HMDB05175
boundary condition: false
initial amount: NaN
is: CHEBI:28111
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_0daa744b_7d3b_44f5_9ad5_d7f3e6a2f19f
boundary condition: true
type: Species
has only substance units: false
constant: false
is encoded by: hsa:7001
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PRDX2

http://identifiers.org/biomodels.db/MODEL1310110013#_b1fd18f5_33c6_4926_899a_e024b19f247d
type: Species
boundary condition: true
is encoded by: hsa:80308
initial amount: NaN
has only substance units: false
name: FLAD1
constant: false
initial concentration: NaN
is: SBO:0000252

metaM pac c
is: HMDB00209
is: CHEBI:18401
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: phenylacetate
boundary condition: false
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
constant: false
initial concentration: 1.0

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_89d0bed0_8577_40c2_843a_ba53463805fa
initial concentration: NaN
initial amount: NaN
name: CHAT
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:1103
is: Q6LEN6
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_18b0d20c_94ed_4b5e_93b9_8021793a08dd
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM ppa c
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17272
is: HMDB00237
initial amount: NaN
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate

metaM phe L e
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
type: Species
is: SBO:0000247
is: CHEBI:17295
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
name: L-phenylalanine
is: HMDB00159
initial concentration: 1.0

metaM 34dhoxmand m
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27637
name: 3,4-Dihydroxymandelate
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
has only substance units: false
is: HMDB01866
boundary condition: false
constant: false
type: Species

metaR r2107
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110013#
reversible: true
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110013#
is described by: ECO:0000000

metaR r1467
type: Reaction
product: MODEL1310110013#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110013#
name: Postulated transport reaction
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_5244043b_86bc_432e_9ce4_61cb7f90b60b
is: P48735
is encoded by: hsa:3418
initial concentration: NaN
name: IDH2
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_7f9eb8bf_3d85_4486_abaa_0f796b278f7e
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:2987
initial amount: NaN
is: Q16774
is: SBO:0000252
name: GUK1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_e90dddbd_fdcd_469b_a897_182805bb3de6
name: _AA081045_1_m
has only substance units: false
is encoded by: hsa:AA081045
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

metaR FAOXC204
name: Beta oxidation of long chain fatty acid
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000269
reversible: false
product: MODEL1310110013#
modifier: MODEL1310110013#

metaR r0822
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000185
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110013#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_7dc72eb0_5809_4919_90dd_468f6d2cecb3
boundary condition: true
initial amount: NaN
has only substance units: false
name: _X63359_1_c
initial concentration: NaN
is encoded by: hsa:X63359
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_b54d4b18_827b_4224_8cf0_4b2ad6eca201
is: Q9NWU1
type: Species
boundary condition: true
initial concentration: NaN
name: OXSM
is encoded by: hsa:54995
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_dee8c513_0ef1_4ba9_9199_d600b4e263e0
is encoded by: hsa:6817
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: SULT1A1
initial amount: NaN

metaR r2509
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110013#
is: SBO:0000185
name: Utilized transport

metaR r0527
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
reversible: true
product: MODEL1310110013#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_706b3837_a44d_43ff_8226_24ed1f50e56f
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6470
name: SHMT1
boundary condition: true

metaR UAG4E
fast: false
name: UDP-N-acetylglucosamine 4-epimerase
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/5.1.3.2
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
is described by: ECO:0000304
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_b1d1d104_818f_4451_8e93_1efc219b6698
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: Q7GXZ4
is encoded by: hsa:4539
name: ND4L
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_c9e9cbb4_30d7_4709_80fe_b20dd14bcff5
is encoded by: hsa:T83654
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: _T83654_1_m
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM man e
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
boundary condition: false
name: D-Mannose
type: Species
constant: false
initial concentration: 1.0
is: HMDB00169
has only substance units: false
is: C00159
is: SBO:0000247
is: CHEBI:16024

metaR THYOXt2
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
product: MODEL1310110013#
name: T4 transport via facilitated diffusion
is described by: ECO:0000269
kinetic law: MODEL1310110013#
reversible: true
type: Reaction
modifier: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
fast: false

metaR r0752
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
modifier: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5

metaM xol25oh r
is: HMDB06247
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
boundary condition: false
name: 25-hydroxycholesterol
has only substance units: false
is: CHEBI:42977
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_8c76bc9a_e875_46aa_a794_68df1a8ca6d3
is encoded by: hsa:427
is: Q13510
type: Species
name: ASAH1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

metaR THP2Ctp
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000185
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM

metaR r2508
product: MODEL1310110013#
reversible: true
is: SBO:0000185
name: Utilized transport
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110013#

metaM odecoa r
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: SBO:0000247
initial amount: NaN
name: oleoyl-CoA(4-)
initial concentration: 1.0
is: CHEBI:57387
type: Species
is: HMDB01322

metaM lpam m
is: CHEBI:17460
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
name: lipoamide
constant: false
boundary condition: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: HMDB00962

metaR CYSGLUexR
reactant: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
fast: false
type: Reaction
product: MODEL1310110013#
name: L-cysteine/L-glutamine reversible exchanger
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304

metaR G3PD1
name: glycerol-3-phosphate dehydrogenase (NAD)
kinetic law: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.8
modifier: MODEL1310110013#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_e868a303_7ec9_4ea0_9baf_14460df794d5
has only substance units: false
name: UAP1L1
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:91373
constant: false
is: Q3KQV9

metaM dctp c
constant: false
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
initial concentration: 1.0
has only substance units: false
is: HMDB00998
type: Species
initial amount: NaN
is: CHEBI:16311
is: C00458
name: dCTP
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_240394ad_fffb_42cd_95a3_08921e190a2d
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:1635
constant: false
name: DCTD
boundary condition: true
is: SBO:0000252
is: P32321
initial concentration: NaN

metaR r2109
type: Reaction
reactant: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_0d7d04da_52af_4581_a485_6339cfd4efd2
is: B3KWF4
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: GALNT11
type: Species
is encoded by: hsa:63917
constant: false

metaR FAOXC225C204m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR PNTOte
is described by: ECO:0000134
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110013#
name: Transport of (R)-Pantothenate
fast: false
is: SBO:0000185
product: MODEL1310110013#

metaM 4hdebrisoquine e
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H14N3O CHARGE: 1 INCHI: InChI=1/C10H13N3O/c11-10(12)13-5-7-3-1-2-4-8(7)9(14)6-13/h1-4,9,14H,5-6H2,(H3,11,12)
is: HMDB06468
name: 4 hydroxy debrisoquine
type: Species

metaR r2507
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
name: Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110013#

metaR 5ADTSTSTERONEtr
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: 5 alpha dihydrotesterone intracellular transport
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_fdc915c7_9751_4a64_9fa3_b3f0a04c24f2
is encoded by: hsa:7371
initial concentration: NaN
boundary condition: true
is: Q9BZX2
name: UCK2
is: SBO:0000252
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaR FAOXC205C185m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaM tetpent6 c
type: Species
initial concentration: 1.0
is: HMDB06322
initial amount: NaN
name: tetracosapentaenoic acid, n-6
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-

metaR PRPNCOAHYDm
is: SBO:0000176
name: Propenoyl-CoA hydrolase (m)
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
modifier: MODEL1310110013#
product: MODEL1310110013#
reversible: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false

metaR GTHOm
kinetic law: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reversible: false
product: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
name: glutathione oxidoreductase
reactant: MODEL1310110013#
is described by: ECO:0000254
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7

http://identifiers.org/biomodels.db/MODEL1310110013#_f2a27465_019b_41c1_9f0b_778a4035a2d7
has only substance units: false
boundary condition: true
name: RDH16
is: O75452
constant: false
is encoded by: hsa:8608
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_bb7edbaa_66f6_4122_85f5_227b6f03b34c
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5152
name: PDE9A
constant: false

metaM pail hs c
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:57880
initial amount: NaN
initial concentration: 1.0

metaM lnlc e
type: Species
name: linoleate
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
has only substance units: false
is: CHEBI:30245
initial amount: NaN
constant: false
is: HMDB00673
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR BAAT3x
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110013#
is described by: ECO:0000304
modifier: MODEL1310110013#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
reactant: MODEL1310110013#
name: bile acid Coenzyme A: amino acid N-acyltransferase
is: SBO:0000176
kinetic law: MODEL1310110013#
reversible: false

metaR r0754
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
product: MODEL1310110013#
fast: false
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM cspg e e
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
initial amount: NaN
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:16040
initial concentration: 1.0
constant: false
is: HMDB00630

metaR r2506
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
name: Utilized transport
product: MODEL1310110013#
fast: false

metaR NMNATr
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.1
is: SBO:0000176
product: MODEL1310110013#
fast: false
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
name: nicotinamide-nucleotide adenylyltransferase
reactant: MODEL1310110013#
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_21eee640_ff6a_4e9f_8068_18af583e7ca3
boundary condition: true
type: Species
name: PROSC
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:11212
initial amount: NaN
is: O94903
constant: false

metaM andrstrn r
initial concentration: 1.0
is: CHEBI:16032
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB00031
has only substance units: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
name: androsterone
type: Species
initial amount: NaN

metaM 35cgmp c
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: 3',5'-cyclic GMP(1-)
initial concentration: 1.0
constant: false
type: Species
is: HMDB01314
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: CHEBI:57746

http://identifiers.org/biomodels.db/MODEL1310110013#_ca311e43_7af2_42f5_9ecb_4b65ca4d3587
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
name: _AA021081_1_r
is encoded by: hsa:AA021081

metaM h2o2 x
is: CHEBI:16240
is: HMDB03125
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: C00027
name: Hydrogen peroxide
boundary condition: false
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaM odecoa c
has only substance units: false
initial amount: NaN
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
is: CHEBI:3793
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r1575
product: MODEL1310110013#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_a9cdc22a_2a07_42d5_8a14_e8ba1ceaea12
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9H845
name: ACAD9
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:28976

metaR DM gpi sig er
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR FAOXC164C143m
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaM 5oxpro e
initial amount: NaN
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57606
boundary condition: false
has only substance units: false
is: HMDB00267
constant: false
name: 5-oxoprolinate

metaR r0753
type: Reaction
modifier: MODEL1310110013#
reversible: true
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110013#
fast: false
is: SBO:0000176

metaM asp L e
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
constant: false
is: CHEBI:29991
boundary condition: false
has only substance units: false
name: L-aspartate(1-)
is: HMDB00191
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR r1576
type: Reaction
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM lnlc c
is: HMDB00673
name: linoleate
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:30245
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial amount: NaN

metaM ppa e
initial amount: NaN
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate
is: CHEBI:17272
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00237

metaR ADSL1
reversible: false
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: adenylosuccinate lyase
is version of: http://identifiers.org/ec-code/4.3.2.2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:

metaM sql r
is: CHEBI:15440
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00256
is: SBO:0000247
boundary condition: false
name: squalene
initial concentration: 1.0

metaR FRDPtc
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
fast: false
name: lipid, flip-flop intracellular transport
reversible: true
kinetic law: MODEL1310110013#

metaR GGLUCT
is version of: http://identifiers.org/ec-code/2.3.2.4
reactant: MODEL1310110013#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
type: Reaction
name: gamma-glutamylcyclotransferase
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
product: MODEL1310110013#
is: SBO:0000185

metaR BDHm
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
kinetic law: MODEL1310110013#
reversible: true
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.30
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
is: SBO:0000176

metaM gthrd m
name: glutathionate(1-)
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57925
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaM pglyc hs e
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:60523
type: Species
name: phosphatidylglycerol(1-)
constant: false
initial concentration: 1.0
boundary condition: false

metaR 5ADTSTSTERONEte
name: 5 alpha dihydrotesterone transport
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
fast: false
reversible: true

metaR r1578
product: MODEL1310110013#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110013#
reversible: true

metaM 5oxpro c
is: HMDB00267
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57606
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: SBO:0000247
name: 5-oxoprolinate

metaR r0755
reversible: true
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is: SBO:0000176
kinetic law: MODEL1310110013#
product: MODEL1310110013#
fast: false
type: Reaction

metaR EX 11 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 11-cis-retinol exchange
type: Reaction

metaR BTNPL
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
name: holocarboxylase synthestase (biotin protein ligase)
is: SBO:0000176
modifier: MODEL1310110013#
reversible: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_0d99554d_8cea_47af_beda_3af8d30c8a23
name: AFMID
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:125061
is: Q63HM1
initial amount: NaN
type: Species
initial concentration: NaN

metaM ksii core2 deg8 l
has only substance units: false
is: CHEBI:12936
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C36H60N3O25X CHARGE: 0
name: keratan sulfate II (core 2-linked), degradation product 8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_6a425acd_60f9_47ef_a91a_a42d3345fe0a
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:728226
initial concentration: NaN
has only substance units: false
name: _728226_1_e
boundary condition: true
constant: false

metaR BTNPLm
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
reactant: MODEL1310110013#
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
reversible: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_eb80ead4_15db_418b_8f4c_a894776816ba
name: ALDH3B1
is: P43353
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:221

metaM c226crn m
has only substance units: false
initial amount: NaN
is: HMDB06510
boundary condition: false
is: SBO:0000247
name: cervonyl carnitine
type: Species
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/127055
constant: false

metaR DAGK hs
name: Diacylglycerol phosphate kinase (homo sapiens)
type: Reaction
product: MODEL1310110013#
is: SBO:0000176
kinetic law: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.107
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000269

metaR r2100
modifier: MODEL1310110013#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM pyam5p c
is: C00647
is: HMDB01555
constant: false
has only substance units: false
name: Pyridoxamine 5'-phosphate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
is: CHEBI:58451
boundary condition: false
is: SBO:0000247
type: Species

metaR r0085
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:

metaR r1571
type: Reaction
is: SBO:0000185
product: MODEL1310110013#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110013#_61478892_e1d7_4c0a_bc6a_1159d8fe5304
constant: false
is encoded by: hsa:56474
initial amount: NaN
has only substance units: false
is: Q9NRF8
initial concentration: NaN
type: Species
name: CTPS2
is: SBO:0000252
boundary condition: true

metaM pglyc hs c
is: HMDB02704
name: pglyc_hs[c]
has only substance units: false
is: SBO:0000247
is: CHEBI:21338
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CHARGE: 0
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4e206197_1d02_41a6_994b_387b7581cb4d
is: SBO:0000252
constant: false
is encoded by: hsa:AI935189
initial concentration: NaN
initial amount: NaN
type: Species
name: _AI935189_1_m
boundary condition: true
has only substance units: false

metaM HC01118 r
is: CHEBI:57310
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
type: Species
has only substance units: false
constant: false
name: presqualene diphosphate(3-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM cs b deg3 l
is: CHEBI:21338
is: SBO:0000247
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB02704
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C37H55NO38S2 CHARGE: -4

metaM 5eipencoa m
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
constant: false
name: 5,8,11,14,17-eicosapentenoylcoa
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_f270e575_9587_4971_b616_afcc02ae3d52
is encoded by: hsa:AV713053
type: Species
constant: false
boundary condition: true
name: _AV713053_1_m
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_57c3cfbe_cb5f_4b65_b4a2_53474420f365
is: SBO:0000252
is encoded by: hsa:10246
initial amount: NaN
boundary condition: true
is: O00624
constant: false
has only substance units: false
type: Species
name: SLC17A2
initial concentration: NaN

metaR LINKDEG2ly
reversible: false
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110013#
fast: false

metaR GASNASE2ly
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/3.5.1.26
modifier: MODEL1310110013#
is: SBO:0000176
reactant: MODEL1310110013#
name: glycosylasparaginase, lysosomal
fast: false
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaM btcoa m
name: Butanoyl-CoA
is: C00136
boundary condition: false
is: CHEBI:57371
is: HMDB01088
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR r0084
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
is: SBO:0000176
fast: false
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#

metaM ksii core2 deg5 l
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 5
notes: FORMULA: C50H82N4O38SX CHARGE: -1
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12936
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_f6f9deb4_83ed_49c6_8490_41a5fbd8b474
initial amount: NaN
constant: false
initial concentration: NaN
name: ALDOA
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:226
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_ebcd258b_6fb6_4d6a_a897_af5308aaae9a
has only substance units: false
is encoded by: hsa:8704
name: B4GALT2
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_f2631cf4_05f0_4afd_8465_fa9a99da828d
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5139
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q14432
name: PDE3A

metaR r0522
product: MODEL1310110013#
reversible: false
reactant: MODEL1310110013#
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is: SBO:0000176
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
type: Reaction

metaR r2102
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110013#
is: SBO:0000185
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110013#
type: Reaction
fast: false
reactant: MODEL1310110013#

metaM clpndcoa x
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
name: clupanodonyl CoA
is: C16166
type: Species
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: SBO:0000247
is: HMDB06267
is: http://identifiers.org/pubchem.compound/47205476

metaR ACACt2
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110013#
fast: false
type: Reaction
is described by: ECO:0000269
name: acetoacetate transport via proton symport

metaR r1573
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM cspg e l
is: CHEBI:36005
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
boundary condition: false
constant: false
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB02183
initial amount: NaN

metaR HEXCt
product: MODEL1310110013#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaR r0083
product: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
fast: false
kinetic law: MODEL1310110013#
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is: SBO:0000176

metaM hmgcoa m
type: Species
has only substance units: false
is: HMDB01375
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
name: Hydroxymethylglutaryl-CoA
is: SBO:0000247
is: CHEBI:15467

metaR r2101
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110013#
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
modifier: MODEL1310110013#

metaR LCYSTCBOXL
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.1.1.15
reversible: false
name: 3-Sulfoalanine carboxy-lyase
is: SBO:0000176
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.1.1.29
fast: false
modifier: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51380.1) or (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110013#_5cb7887d_7150_4547_b64e_84b9f73b2b04
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: NDUFB6
is: Q5VYT2
constant: false
is encoded by: hsa:4712
boundary condition: true

metaR r1574
product: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reversible: true
is: SBO:0000185
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR L LACt4r
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
name: L-lactate reversible transport via sodium symport
product: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM asp L c
constant: false
initial amount: NaN
name: L-aspartate(1-)
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191
initial concentration: 1.0
boundary condition: false
is: CHEBI:29991
type: Species
has only substance units: false

metaR ST8SIA51g
product: MODEL1310110013#
name: Beta-galactoside alpha-2,3-sialyltransferase
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reversible: false
reactant: MODEL1310110013#
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110013#
is: SBO:0000176
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_38ae3350_cd5b_4764_a44e_f5267574f339
constant: false
is: D6RDW3
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:2982
is: SBO:0000252
boundary condition: true
name: GUCY1A3

metaR AHCYStd
is described by: ECO:0000134
fast: false
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
reversible: true
kinetic law: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
name: diffusion of S-Adenosyl-L-homocysteine
type: Reaction

metaR r0311
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR MALTSULtm
name: Malate:thiosulfate antiport, mitochondrial
product: MODEL1310110013#
is described by: ECO:0000269
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_765623d4_1156_4aeb_b3da_8842ee928271
constant: false
is: SBO:0000252
initial amount: NaN
name: _H17063_1_m
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:H17063

http://identifiers.org/biomodels.db/MODEL1310110013#_c37ba3b2_e815_409f_b42f_5bf0e968979d
has only substance units: false
is: P37268
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: FDFT1
initial amount: NaN
is encoded by: hsa:2222
type: Species
constant: false

metaR S6TASE20ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
fast: false
type: Reaction
product: MODEL1310110013#
modifier: MODEL1310110013#

metaM cmpacna g
constant: false
type: Species
is: HMDB01176
boundary condition: false
initial concentration: 1.0
name: CMP-N-acetyl-beta-neuraminate(2-)
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR GHMT2r
is version of: http://identifiers.org/ec-code/2.1.2.1
name: glycine hydroxymethyltransferase, reversible
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is described by: ECO:0000269
fast: false
is: SBO:0000176
modifier: MODEL1310110013#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_e0200017_f52a_4391_81a8_baccc250be41
initial concentration: NaN
is: P15309
name: ACPP
is encoded by: hsa:55
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_9a69d62b_7fba_4877_8781_afb9f3056a39
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: PIK3R1
initial concentration: NaN
is: B3KT19
is encoded by: hsa:5295
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_023f06c2_6a88_4428_b467_b9541f43f185
type: Species
is: P78356
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8396
name: PIP4K2B

metaM fadh2 x
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:58307
name: FADH2(2-)
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
is: HMDB01197

metaR ICDHyrm
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
fast: false
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Isocitrate dehydrogenase (NADP+)
kinetic law: MODEL1310110013#
reversible: true

metaR AHCYSte
fast: false
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
name: Transport of S-adenosyl-L-homocysteine
reactant: MODEL1310110013#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110013#

metaR UPPN
is: SBO:0000176
modifier: MODEL1310110013#
name: b-ureidopropionase
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.5.1.6
is described by: ECO:0000269
type: Reaction
reversible: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
fast: false

metaR r2130
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
is: SBO:0000185
product: MODEL1310110013#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110013#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM gmp g
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:58115
is: HMDB01397
initial concentration: 1.0
name: GMP(3-)
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110013#_e9c38aea_d820_4a4f_a2b5_872e0d11a18a
constant: false
boundary condition: true
initial amount: NaN
is: Q96C36
type: Species
initial concentration: NaN
is encoded by: hsa:29920
name: PYCR2
is: SBO:0000252
has only substance units: false

metaM ddcacoa x
is: CHEBI:57375
is: C01832
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: SBO:0000247
name: Dodecanoyl-CoA (n-C12:0CoA)
boundary condition: false
constant: false
has only substance units: false
is: HMDB03571

metaR GLYt7 311 r
type: Reaction
is described by: ECO:0000006
reactant: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
modifier: MODEL1310110013#
reversible: true
product: MODEL1310110013#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
kinetic law: MODEL1310110013#

metaR r0962
reversible: false
is: SBO:0000185
product: MODEL1310110013#
type: Reaction
name: Facilitated diffusion
fast: false
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:

metaM lnlncg r
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: gamma-linolenate
initial amount: NaN
is: CHEBI:32391
is: HMDB03073
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_8d86e6b3_15c0_4278_a25c_e991cce7690a
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:57194
name: ATP10A
constant: false
has only substance units: false
is: SBO:0000252
is: O60312
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_1afd6a56_0959_44d6_8378_e582ab0fd2af
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: CLYBL
type: Species
is encoded by: hsa:171425
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_0cd863b1_6b0f_43e4_82ec_183683f6240d
initial amount: NaN
is encoded by: hsa:471
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: ATIC
boundary condition: true
is: P31939

metaM glx x
initial amount: NaN
is: CHEBI:36655
name: glyoxylate
initial concentration: 1.0
has only substance units: false
is: HMDB00119
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
boundary condition: false
is: SBO:0000247
constant: false
type: Species

metaM asp L m
is: SBO:0000247
has only substance units: false
is: HMDB00191
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: CHEBI:29991
initial amount: NaN
boundary condition: false
name: L-aspartate(1-)

metaR r2521
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
name: Utilized transport
type: Reaction
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_143bc716_8bf8_4a5e_b672_bb87f4847fb5
boundary condition: true
has only substance units: false
type: Species
is: Q6P1K9
name: PANK2
is encoded by: hsa:80025
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaM sphings l
is: SBO:0000247
name: sphingosine(1+)
has only substance units: false
is: CHEBI:57756
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00252
constant: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319

http://identifiers.org/biomodels.db/MODEL1310110013#_358c544b_354c_4d47_8495_af84fcedd35d
boundary condition: true
is: P19404
is encoded by: hsa:4729
initial concentration: NaN
initial amount: NaN
name: NDUFV2
constant: false
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_c770fc33_b140_41c6_a895_014e2d672948
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: E7EX19
is encoded by: hsa:5295
name: PIK3R1
is: SBO:0000252
constant: false
boundary condition: true

metaR ETF
modifier: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
fast: false
name: electron transfer flavoprotein
type: Reaction
is: SBO:0000176
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false

metaR GALGLUSIDEtl
is: SBO:0000185
fast: false
type: Reaction
name: galgluside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#

metaM HC01223 m
initial amount: NaN
has only substance units: false
constant: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
boundary condition: false
type: Species
is: CHEBI:57340
is: SBO:0000247
initial concentration: 1.0

metaM HC01104 e
name: 4-nitrophenyl phosphate(2-)
constant: false
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:61146
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR GALASE5ly
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
modifier: MODEL1310110013#
reactant: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_1fe87cdf_980f_4d0d_a208_4d63fe46042e
boundary condition: true
is: P11310
initial amount: NaN
constant: false
is encoded by: hsa:34
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: ACADM

http://identifiers.org/biomodels.db/MODEL1310110013#_680c4629_430f_4db5_8aa4_15133d515e45
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:1120
is: Q9Y259
name: CHKB
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR r0310
is: SBO:0000176
reactant: MODEL1310110013#
is described by: ECO:0000000
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reversible: false
fast: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_a293ca41_0bc0_4708_ba26_d8f2bee3b9aa
has only substance units: false
name: ESPN
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: B1AK53
is: SBO:0000252
is encoded by: hsa:83715

http://identifiers.org/biomodels.db/MODEL1310110013#_0fcadc39_8bf2_490a_b2b6_f68eddd3b5d4
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: O95954
has only substance units: false
name: FTCD
is encoded by: hsa:10841
is: SBO:0000252
constant: false

metaM mgacpail hs r
is: C00249
is: CHEBI:7896
is: SBO:0000247
is: HMDB00220
initial concentration: 1.0
initial amount: NaN
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species

metaR r0960
fast: false
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_2f6138cb_f189_4e71_9ab5_ccb32e92e299
constant: false
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:4731
name: NDUFV3
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaM coumarin e
is: CHEBI:28794
constant: false
name: coumarin
is: SBO:0000247
notes: FORMULA: C9H6O2 CHARGE: 0 INCHI: InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
initial concentration: 1.0
is: HMDB01218
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_72aa1035_cc30_4e80_948c_09eb7e2b521e
initial concentration: NaN
name: IDH3B
is: SBO:0000252
boundary condition: true
has only substance units: false
is: O43837
initial amount: NaN
type: Species
is encoded by: hsa:3420
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_937ba848_f07c_4d54_a1f0_5106affb067a
initial amount: NaN
name: SLC6A7
is: Q99884
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:6534
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_71706446_98fe_480c_bfde_e5db47540dba
is encoded by: hsa:5169
type: Species
boundary condition: true
name: ENPP3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: Q308M7

http://identifiers.org/biomodels.db/MODEL1310110013#_6ffefdf5_9907_4319_beec_508f7208b7e5
is: Q9BTU6
initial amount: NaN
is encoded by: hsa:55361
is: SBO:0000252
initial concentration: NaN
name: PI4K2A
constant: false
boundary condition: true
type: Species
has only substance units: false

metaM thr L c
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
is: HMDB00167
name: L-threonine
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR TPI
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.1
kinetic law: MODEL1310110013#
name: triose-phosphate isomerase
reversible: true
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is: SBO:0000176
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction

metaM nadp x
constant: false
is: CHEBI:58349
is: SBO:0000247
type: Species
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
is: HMDB00217
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c1ccbd8f_c760_4a7f_95ca_d5bb35851786
initial concentration: NaN
type: Species
has only substance units: false
is: Q9HAS3
is: SBO:0000252
is encoded by: hsa:64078
name: SLC28A3
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_133b93b0_ccc5_4299_bbaf_1d783b85603f
type: Species
initial concentration: NaN
name: ALDH2
constant: false
has only substance units: false
is encoded by: hsa:217
is: P05091
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR TYRCBOX
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
name: L-Tyrosine carboxy-lyase
type: Reaction
reversible: false
modifier: MODEL1310110013#
is described by: ECO:0000134
reactant: MODEL1310110013#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.1.1.28

metaR SPHS1Ptr
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000185
name: sphingosine-1-phosphate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110013#
type: Reaction

metaR r1904
kinetic law: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false

metaM ascb L e
is: CHEBI:38290
initial amount: NaN
is: SBO:0000247
is: HMDB00044
has only substance units: false
name: L-ascorbate
boundary condition: false
constant: false
type: Species
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial concentration: 1.0

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_5ab46b6a_08e8_4786_a621_5931ca728ae8
constant: false
is encoded by: hsa:427
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q96AS2
initial amount: NaN
name: ASAH1
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4d5ba17c_ea86_4fae_b621_90036494eb5b
is: P14550
constant: false
initial amount: NaN
is encoded by: hsa:10327
has only substance units: false
type: Species
boundary condition: true
name: AKR1A1
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_b3b1c291_876a_47c4_ad07_22b49279eb41
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: _AA526438_1_m
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AA526438

metaR PROSTGH2t
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
fast: false
name: Prostaglandin H2 transport
product: MODEL1310110013#
reactant: MODEL1310110013#

metaM gmp c
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: HMDB01397
is: C00144
name: GMP
boundary condition: false

metaR NACHEX8ly
modifier: MODEL1310110013#
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR RE3005M
name: RE3005
reversible: true
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_2816c2ae_3871_460d_8e1b_62d07f7b4677
name: ACAA1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:30
type: Species
boundary condition: true
initial amount: NaN
is: Q96CA6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_cec19b13_3a98_4eee_8804_c1422e768abc
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC6A5
boundary condition: true
is encoded by: hsa:9152
is: Q9Y345
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_77e5e10d_44bb_4153_b16a_0fdb2a53d3d4
has only substance units: false
constant: false
boundary condition: true
name: MYO5B
initial amount: NaN
is: Q9H6Y6
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4645
type: Species

metaR PRODt2r
product: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
modifier: MODEL1310110013#
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110013#
fast: false
is: SBO:0000185
name: D-proline reversible transport via proton symport
reversible: true

metaR B MANNASEly
is: SBO:0000176
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.25
fast: false
reversible: false
name: beta-mannosidase, lysosomal
reactant: MODEL1310110013#
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
type: Reaction
product: MODEL1310110013#

metaR PVD3
reversible: true
fast: false
is described by: ECO:0000134
is: SBO:0000176
name: Previtamin D3 formation
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT

http://identifiers.org/biomodels.db/MODEL1310110013#_61cbf4d1_83f9_48c5_bcbf_e1e5746f18c0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P09669
name: COX6C
is encoded by: hsa:1345
type: Species

metaM thr L e
is: SBO:0000247
is: HMDB00167
initial concentration: 1.0
is: CHEBI:16857
name: L-threonine
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_9dcb451e_2068_4070_95c3_1e4a6b9abf59
is: P52824
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: DGKQ
is encoded by: hsa:1609
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_95410f44_3fe1_4950_9334_810192cf7624
is: SBO:0000252
type: Species
name: PDE9A
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaR DM dem2emgacpail prot hs r
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dem2emgacpail prot hs(r)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_46476db3_d0c3_4b48_88ef_feef2b6f86cd
is encoded by: hsa:5373
name: PMM2
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: O15305
boundary condition: true
type: Species
initial concentration: NaN

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR GLUDC
notes: GENE_ASSOCIATION: (2571.1) or (2572.1) or (2571.2) SUBSYSTEM: Glutamate metabolism EC Number: 4.1.1.15 Confidence Level: 4 AUTHORS: PMID:1924293,PMID:8088791 NOTES:JLR- added h to balance
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.15
name: Glutamate Decarboxylase
product: MODEL1310110013#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
type: Reaction
modifier: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_32ffe659_2440_4ef9_b71a_a29716ac147e
is: SBO:0000297
is encoded by: hsa:51227
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
type: Species
has only substance units: false

metaM hs deg10 l
is: CHEBI:15748
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
initial amount: NaN
name: heparan sulfate, degradation product 10
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00127
boundary condition: false
initial concentration: 1.0
type: Species

metaR UMPK5n
fast: false
type: Reaction
product: MODEL1310110013#
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
name: UMP kinase (dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110013#
is: SBO:0000176

metaM ascb L c
is: CHEBI:38290
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: L-ascorbate
is: HMDB00044
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaM CE5118 m
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:57923
type: Species
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118

metaR CYTK7n
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110013#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,UTP),nuclear
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR r1906
modifier: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is: SBO:0000185
fast: false
name: Y+LAT2 Utilized transport

metaR r0963
kinetic law: MODEL1310110013#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
type: Reaction
product: MODEL1310110013#
is described by: ECO:0000000
name: Facilitated diffusion
fast: false
reactant: MODEL1310110013#

metaM h2o2 c
is: C00027
constant: false
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: HMDB03125
boundary condition: false
initial amount: NaN
name: Hydrogen peroxide
has only substance units: false
is: CHEBI:16240
initial concentration: 1.0

metaM gmp e
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58115
constant: false
is: HMDB01397
boundary condition: false
type: Species
name: GMP(3-)
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_87dccc77_3678_4d2d_af09_8a81e0989fa2
constant: false
is: Q13825
is encoded by: hsa:549
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: AUH
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_a167dfeb_8d8f_4828_9ebc_3e36374783d4
boundary condition: true
is encoded by: hsa:81031
type: Species
initial concentration: NaN
is: O95528
has only substance units: false
initial amount: NaN
constant: false
name: SLC2A10
is: SBO:0000252

metaM acgam6p c
is: HMDB01062
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
name: N-acetyl-D-glucosamine 6-phosphate(2-)
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57513

metaR GALGLUSIDEtg
fast: false
kinetic law: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
name: galgluside hs intracellular transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaR RE0512M
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is described by: ECO:0000000
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
name: RE0512
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR r1579
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
product: MODEL1310110013#
is: SBO:0000185
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_0b6e8273_f0ce_4cff_95d4_4478681ef169
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9187
type: Species
has only substance units: false
constant: false
initial concentration: NaN
name: SLC24A1
is: B4DUG1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_854bcfa6_c15e_4511_bc3a_31a9219d9061
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4758
is: Q99519
constant: false
name: NEU1
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_c54117e1_4408_4596_ae4f_f3f94d8abdd5
name: PDE6A:PDE6H:PDE6B
constant: false
has part: Q13956
is encoded by: hsa:5158
has part: P16499
initial amount: NaN
is encoded by: hsa:5149
type: Species
has only substance units: false
boundary condition: true
has part: B7Z9T9
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:5145

http://identifiers.org/biomodels.db/MODEL1310110013#_5020e53e_0f90_42da_bfcb_bbbabd91d57a
is: Q92536
name: SLC7A6
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:9057

metaR RE0944E
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
product: MODEL1310110013#
name: RE0944
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
modifier: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.17

metaR PAFt
is: SBO:0000185
type: Reaction
reversible: true
fast: false
product: MODEL1310110013#
reactant: MODEL1310110013#
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
kinetic law: MODEL1310110013#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR LNLNCAt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
product: MODEL1310110013#
type: Reaction
is: SBO:0000185
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110013#_24eeb85d_b26a_4072_a19a_73c59fb8aef0
initial concentration: NaN
initial amount: NaN
name: _AA081045_1_c
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:AA081045
type: Species

metaM thbpt4acam n
is: SBO:0000247
is: CHEBI:15374
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
boundary condition: false
type: Species
initial amount: NaN
is: HMDB02281
constant: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_89e50567_3ac6_402f_b9d7_fb13dbb25587
initial concentration: NaN
is: SBO:0000252
name: PIGL
type: Species
is: Q9Y2B2
has only substance units: false
is encoded by: hsa:9487
constant: false
initial amount: NaN
boundary condition: true

metaM HC02208 e
has only substance units: false
name: prostaglandin-d1
constant: false
is: SBO:0000247
is: CHEBI:27696
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false

metaM dlnlcg e
is: SBO:0000247
has only substance units: false
name: dihomo-gamma-linolenic acid (n-6)
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:53486
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
type: Species
initial amount: NaN
is: HMDB02925

http://identifiers.org/biomodels.db/MODEL1310110013#_1a8fd712_9607_4539_bbd9_d8e8928f3d93
is encoded by: hsa:1717
name: DHCR7
is: Q9UBM7
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true

metaM slfcys c
notes: FORMULA: C3H8NO5S2 CHARGE: -1
initial amount: NaN
constant: false
name: S-Sulfo-L-cysteine
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00731
type: Species
is: C05824

metaM dc2coa x
constant: false
name: trans-Dec-2-enoyl-CoA
boundary condition: false
is: HMDB01168
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_e7bfb596_9edd_4b23_beb8_e6990f76b8ca
is encoded by: hsa:37
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACADVL
is: P49748

metaM hs deg12 l
is: SBO:0000247
boundary condition: false
is: HMDB06210
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 12
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
constant: false
initial amount: NaN
type: Species

metaR GCC2bim
fast: false
is: SBO:0000176
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.4.4.2
reactant: MODEL1310110013#
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110013#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_dabd09fe_5e2f_4b78_aaed_8e58b0203571
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:54677
name: CROT
is: E7EQF2
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_7b24b27c_6591_42a0_a97e_5dac0eaa4379
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2645
name: GCK
has only substance units: false
initial concentration: NaN
type: Species
is: P35557
constant: false
boundary condition: true

metaR SGPL12r
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
fast: false
type: Reaction
name: Sphingosine-1-phosphate lyase
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.1.2.27
is described by: ECO:0000304
reversible: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
is: SBO:0000176

metaR r1020
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM h2o2 e
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
is: CHEBI:16240

http://identifiers.org/biomodels.db/MODEL1310110013#_d94fa390_2bc4_4a8c_baf3_d78e4cb3cae1
type: Species
is: SBO:0000252
name: ECHS1
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is: P30084
is encoded by: hsa:1892
initial concentration: NaN

metaM 4hdebrisoquine c
notes: FORMULA: C10H14N3O CHARGE: 1 INCHI: InChI=1/C10H13N3O/c11-10(12)13-5-7-3-1-2-4-8(7)9(14)6-13/h1-4,9,14H,5-6H2,(H3,11,12)
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 4 hydroxy debrisoquine
is: HMDB06468
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

metaR r0317
modifier: MODEL1310110013#
product: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
reactant: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.8.1.4

metaM dlnlcg c
is: HMDB02925
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
boundary condition: false
constant: false
is: CHEBI:53486
type: Species
has only substance units: false
initial amount: NaN
name: dihomo-gamma-linolenic acid (n-6)

metaR Htg
reversible: true
fast: false
product: MODEL1310110013#
name: proton diffusion (Golgi)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#

metaR PACCOAL
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110013#
reversible: false
is described by: ECO:0000000
name: phenylacetate-CoA ligase
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
type: Reaction

metaR FRDPtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
fast: false
name: lipid, flip-flop intracellular transport
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is: SBO:0000185

metaM slfcys e
constant: false
notes: FORMULA: C3H8NO5S2 CHARGE: -1
initial amount: NaN
is: HMDB00731
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: S-Sulfo-L-cysteine
type: Species
has only substance units: false
is: C05824

metaM 10fthf7glu e
is: CHEBI:57454
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00972
boundary condition: false
initial amount: NaN
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial concentration: 1.0
type: Species
name: 10-formyltetrahydrofolate-[Glu](7)

http://identifiers.org/biomodels.db/MODEL1310110013#_3cf45fee_e0cf_48ea_b1d2_08d9718c7136
name: SLC26A2
boundary condition: true
type: Species
initial concentration: NaN
is: P50443
is: SBO:0000252
is encoded by: hsa:1836
initial amount: NaN
constant: false
has only substance units: false

metaR FAOXC184C164x
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaM 3pg m
is: HMDB00807
initial concentration: 1.0
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: CHEBI:58272
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
has only substance units: false

metaR NAGA2ly
is described by: ECO:0000000
reactant: MODEL1310110013#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.49
kinetic law: MODEL1310110013#
type: Reaction
modifier: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
name: N-acetylgalactosaminidase, alpha-
fast: false

metaM mag hs e
is: SBO:0000247
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
name: monoacylglycerol 2
constant: false
is: HMDB03073
initial amount: NaN
boundary condition: false
is: CHEBI:32391
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_66239c0c_42b8_4bd1_9442_1058cd8c28fc
has only substance units: false
is encoded by: hsa:5290
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:5296
type: Species
has part: P42336
name: PIK3CA:PIK3R2
has part: O00459
boundary condition: true
is: SBO:0000297

metaM cmpacna n
is: HMDB01176
constant: false
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
is: CHEBI:57812
boundary condition: false
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_d9eaead5_7f56_4311_bcc2_f6eec5376254
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:196883
is: Q8NFM4
name: ADCY4
initial amount: NaN

metaM sphings c
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: sphingosine(1+)
constant: false
initial concentration: 1.0
is: HMDB00252
is: CHEBI:57756
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_3142cc2f_bb81_4e74_90a0_b75c9b616b21
has only substance units: false
boundary condition: true
initial concentration: NaN
name: GALNT10
is: Q86SR1
type: Species
is: SBO:0000252
is encoded by: hsa:55568
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_58f5ac1d_ea45_49ae_8383_5908af25474e
type: Species
boundary condition: true
is encoded by: hsa:51022
initial concentration: NaN
name: GLRX2
constant: false
initial amount: NaN
is: SBO:0000252
is: Q9NS18
has only substance units: false

metaM dgdp c
is: C00361
initial concentration: 1.0
boundary condition: false
is: HMDB00960
constant: false
has only substance units: false
type: Species
name: dGDP
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: CHEBI:58595

metaR GGH 6DHFe
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (6DHF), extracellular
is: SBO:0000176
reversible: false
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_a98d6cf1_9d71_4404_b0e0_6fca0863cc1e
type: Species
is encoded by: hsa:8776
has only substance units: false
is: Q13613
initial concentration: NaN
name: MTMR1
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_f6e8e79b_adc1_44b0_aaf6_7f25863fc234
is encoded by: hsa:5152
name: PDE9A
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM CE5121 m
initial amount: NaN
is: CHEBI:57449
boundary condition: false
initial concentration: 1.0
name: trans-3-decenoyl-CoA
constant: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110013#_5df9da7a_c71d_4270_b715_46682c0988c1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:515
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: Q08ET0
name: ATP5F1

metaR KYNATESYN
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_aa49bce7_40b7_4df3_b920_4678319026d3
is: Q9BZQ4
is encoded by: hsa:23057
type: Species
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: NMNAT2
initial amount: NaN
initial concentration: NaN

metaR LEUTAm
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: leucine transaminase, mitochondrial
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110013#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_70dd1fb1_bc10_45f2_be94_585a35d42d16
boundary condition: true
type: Species
name: NIT2
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9NQR4
is encoded by: hsa:56954

http://identifiers.org/biomodels.db/MODEL1310110013#_630b86fc_5324_4427_88e6_a389978d120f
initial amount: NaN
constant: false
is encoded by: hsa:2936
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: P00390
name: GSR
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_29a002ca_945b_4464_a6f5_28c6e169a9ec
initial amount: NaN
is: Q8WUX1
is encoded by: hsa:92745
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: SLC38A5
initial concentration: NaN

metaM lnlncg l
is: CHEBI:32391
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
name: gamma-linolenate
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB03073

metaM tmndnccoa c
is: HMDB06514
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: timnodonyl coenzyme A
initial amount: NaN
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
boundary condition: false

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_45d751eb_6ef2_49a4_947b_126a5d3dee7b
has only substance units: false
initial amount: NaN
is encoded by: hsa:347734
name: SLC35B2
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q8TB61

metaR RE2974C
reactant: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
is: SBO:0000176
product: MODEL1310110013#
name: RE2974
reversible: true
kinetic law: MODEL1310110013#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.149
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.68

metaM cysam c
is: HMDB02991
is: CHEBI:58029
constant: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
name: cysteaminium
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM srtn e
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
boundary condition: false
name: serotonin(1+)
is: SBO:0000247
initial amount: NaN
is: CHEBI:350546
is: HMDB00259
type: Species
constant: false
initial concentration: 1.0

metaR GNMT
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.20
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
reactant: MODEL1310110013#
fast: false
reversible: false
name: glycine N-methyltransferase

http://identifiers.org/biomodels.db/MODEL1310110013#_97839a7a_55e9_42eb_b734_ef3c1222f183
is encoded by: hsa:54539
constant: false
name: NDUFB11
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9NX14
initial amount: NaN
boundary condition: true
type: Species

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_092bc89e_537e_48d7_a461_1efab2bf3f50
initial concentration: NaN
is: P51553
type: Species
constant: false
is encoded by: hsa:3421
name: IDH3G
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

metaR r2411
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is described by: ECO:0000000
reactant: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_437a6973_09cd_492c_b0ea_ce0b585e0848
initial amount: NaN
is encoded by: hsa:570
initial concentration: NaN
has only substance units: false
constant: false
is: Q14032
type: Species
boundary condition: true
name: BAAT
is: SBO:0000252

metaR FUMtm
modifier: MODEL1310110013#
reversible: true
reactant: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110013#
name: fumarate transport, mitochondrial
kinetic law: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV

metaM h2o2 m
is: HMDB03125
type: Species
name: Hydrogen peroxide
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:16240
constant: false

metaM mthgxl e
name: methylglyoxal
boundary condition: false
has only substance units: false
constant: false
type: Species
is: CHEBI:17158
initial amount: NaN
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
is: SBO:0000247
initial concentration: 1.0

metaM L2aadp6sa c
name: L-allysine
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:17917
is: HMDB01263
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_461f3b6b_14a9_415d_9945_6052941d8d45
is: B7Z5G2
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2629
constant: false
has only substance units: false
initial concentration: NaN
name: GBA

metaR N4Tg
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
type: Reaction
fast: false
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110013#

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_7fae03ba_e613_482c_831f_9c084dad8591
initial amount: NaN
is: SBO:0000252
name: COX6B1
initial concentration: NaN
has only substance units: false
is: P14854
constant: false
type: Species
boundary condition: true
is encoded by: hsa:1340

metaM 3mb2coa m
boundary condition: false
is: SBO:0000247
is: CHEBI:57344
type: Species
has only substance units: false
is: HMDB01493
constant: false
initial concentration: 1.0
name: 3-methylbut-2-enoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069

metaR FAOXC260240x
reactant: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: false
name: Beta oxidation of long chain fatty acid
type: Reaction
kinetic law: MODEL1310110013#
fast: false

metaR PI45P5P
is version of: http://identifiers.org/ec-code/3.1.3.36
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
modifier: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000176
fast: false
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110013#_8298fc63_1322_4a30_8065_f3605dfc6080
constant: false
is encoded by: hsa:50487
is: SBO:0000252
boundary condition: true
is: Q9NZ20
type: Species
initial amount: NaN
has only substance units: false
name: PLA2G3
initial concentration: NaN

metaM srtn c
is: HMDB00259
is: SBO:0000247
is: CHEBI:350546
type: Species
constant: false
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
boundary condition: false
name: serotonin(1+)
initial amount: NaN
initial concentration: 1.0

metaM HC00695 m
initial amount: NaN
name: S-Succinyldihydrolipoamide
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: CHEBI:17432
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaM CE2434 m
initial concentration: 1.0
type: Species
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
is: CHEBI:57795
initial amount: NaN
constant: false

metaM ru5p D c
has only substance units: false
is: HMDB00618
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: D-ribulose 5-phosphate(2-)
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58121
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

http://identifiers.org/biomodels.db/MODEL1310110013#_a9aa478a_c5dd_44ae_8386_48241c5a6eed
initial concentration: NaN
has only substance units: false
name: B3GALNT1
is: O75752
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:8706

metaM pail5p hs c
is: SBO:0000247
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaR r1581
reversible: true
is: SBO:0000185
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR ACALDtm
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
name: acetaldehyde mitochondrial diffusion
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000000
reversible: true

metaR H6ET3er
is: SBO:0000176
modifier: MODEL1310110013#
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.1
type: Reaction
reversible: false
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110013#_1ad589d1_4706_487c_bdcb_a3c09da30524
constant: false
name: SLC4A5
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:57835
boundary condition: true
is: Q9BY07

metaR DURIPP
name: deoxyuridine phosphorylase
modifier: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.3
kinetic law: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR

metaM ru5p D r
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00618
is: SBO:0000247
is: CHEBI:58121
type: Species
initial amount: NaN
boundary condition: false
name: D-ribulose 5-phosphate(2-)

metaR FBP26
is version of: http://identifiers.org/ec-code/3.1.3.11
name: Fructose-2,6-bisphosphate 2-phosphatase
fast: false
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.7.1.105
is: SBO:0000176
product: MODEL1310110013#
reversible: false
type: Reaction
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
is described by: ECO:0000000
reactant: MODEL1310110013#

metaM dcdp c
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: C00705
is: SBO:0000247
constant: false
name: dCDP
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
is: CHEBI:58593

metaM HC01603 c
has only substance units: false
name: 10-Formyltetrahydrofolate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57454
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: C00234
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_931970c6_dd55_4e7e_a56c_2d7de06cf273
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: _AA576959_1_c
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AA576959

metaR NADPHtru
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
reversible: false
name: NADPH transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110013#_6a2ea00f_3913_45ee_b08c_0aa79b71cb1e
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9NWU1
boundary condition: true
name: OXSM
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:54995

metaR r0817
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
kinetic law: MODEL1310110013#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110013#

metaR CO2t
fast: false
reactant: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
name: CO2 transporter via diffusion
reversible: true
kinetic law: MODEL1310110013#
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_d1a8d0fa_8081_4f11_a4c4_556142b105f1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10087
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is: Q9Y5P4
initial amount: NaN
name: COL4A3BP

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR r2402
fast: false
reversible: false
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110013#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_1d7e0dfa_f6ec_48dd_97d9_6b9e879efae7
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: ACAD11
initial amount: NaN
constant: false
is encoded by: hsa:84129
is: Q709F0

metaR SPMTDe
reversible: true
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000134
name: SPMTDe
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_4745b81c_ea4d_4ce2_9be9_5695c79784d1
initial concentration: NaN
constant: false
is: B4DER4
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:5291
is: SBO:0000252
name: PIK3CB
initial amount: NaN

metaM xol7ah3 m
initial amount: NaN
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:28540
initial concentration: 1.0
is: HMDB12455
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,26-triol

metaM ala B m
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
type: Species
initial amount: NaN
is: CHEBI:16958
name: beta-alanine
initial concentration: 1.0
is: HMDB00056
constant: false
boundary condition: false

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM arachcrn m
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06460
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_86ac14c4_1713_4c51_b050_56f2dff34acf
name: SLC8A3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:6547
type: Species

metaR GALASE14ly
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
name: beta-galactosidase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5

metaM dc2coa m
name: trans-Dec-2-enoyl-CoA
has only substance units: false
is: CHEBI:61406
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275

metaM sbcoa x
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
name: suberylcoa

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaR LCADi D
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is: SBO:0000176
name: lactaldehyde dehydrogenase
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110013#
fast: false
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD

metaR GLYt7 211 r
reversible: true
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction

metaM sarcs m
type: Species
initial amount: NaN
is: HMDB00271
name: Sarcosine
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: C00213
is: CHEBI:15611
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_69a8a767_8082_450f_8794_5d874c4b73f3
name: _D29675_1_c
is encoded by: hsa:D29675
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaM debrisoquine e
initial concentration: 1.0
boundary condition: false
is: HMDB06543
initial amount: NaN
notes: FORMULA: C10H14N3 CHARGE: 1 INCHI: InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
is: CHEBI:34665
constant: false
type: Species
name: debrisoquine
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_11067e84_aa70_40e9_8082_46eba851a4ca
name: ACSS1
type: Species
is encoded by: hsa:84532
boundary condition: true
constant: false
is: Q9NUB1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110013#_f809f264_fddf_4877_8bd9_731fce748428
boundary condition: true
initial amount: NaN
name: NDUFB9
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:4715
is: Q9Y6M9
is: SBO:0000252

metaR r1580
reactant: MODEL1310110013#
reversible: true
product: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM hs deg19 l
type: Species
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: HMDB06210
name: heparan sulfate, degradation product 19
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM octa e
name: octanoate (n-C8:0)
is: CHEBI:25646
is: C06423
type: Species
is: HMDB00482
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C8H15O2 CHARGE: -1
initial amount: NaN

metaR r2404
kinetic law: MODEL1310110013#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
reversible: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
modifier: MODEL1310110013#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_74787f18_c384_42c4_8379_840b0b7bdeb7
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3992
has only substance units: false
constant: false
name: FADS1
boundary condition: true
is: O60427
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_7484410e_07a7_4aa3_889b_214ec51a3e83
type: Species
name: ACSL3
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:2181
boundary condition: true
is: B3KMA6
initial concentration: NaN
initial amount: NaN

metaM ksi deg12 l
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
constant: false
is: HMDB00143
name: keratan sulfate I, degradation product 12
is: CHEBI:12936
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_9b445cc4_6f67_433b_af72_f687d3c2b147
is encoded by: hsa:108
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: ADCY2
initial amount: NaN
has only substance units: false
is: Q71UM8

http://identifiers.org/biomodels.db/MODEL1310110013#_e9a8e9e5_ff3a_411d_991c_bd21c3604fee
has only substance units: false
is encoded by: hsa:2582
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q38G75
boundary condition: true
constant: false
type: Species
name: GALE

metaM lnlncg e
constant: false
is: SBO:0000247
name: gamma-linolenate
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: HMDB03073
is: CHEBI:32391
initial amount: NaN

metaM mi1345p c
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: SBO:0000247
is: HMDB01059
has only substance units: false
is: CHEBI:57895
initial concentration: 1.0
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial amount: NaN
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_8de5b878_9913_405d_8e79_f77ade55c3d7
initial concentration: NaN
is encoded by: hsa:5313
type: Species
is: P30613
is: SBO:0000252
boundary condition: true
name: PKLR
initial amount: NaN
constant: false
has only substance units: false

metaM ddcacoa c
boundary condition: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
constant: false
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: C01832
is: CHEBI:57375
is: HMDB03571
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaR SUCCOAPET
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reactant: MODEL1310110013#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_3e046a07_ece6_4d59_b64a_498abfd9dcd6
is encoded by: hsa:3420
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000297
name: IDH3A:IDH3B:IDH3G
has only substance units: false
boundary condition: true

metaR AHCYStr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
name: S-Adenosyl-L-homocysteine intracellular diffusion
reactant: MODEL1310110013#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#

metaR XOLTRIOLtm
name: lipid, flip-flop intracellular transport
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110013#
is: SBO:0000185

metaR r0813
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
modifier: MODEL1310110013#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_2e163bb6_b90f_449d_89c2_87c1f73316c5
has only substance units: false
type: Species
boundary condition: true
name: PANK4
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9NVE7
is encoded by: hsa:55229
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_4fd6fbe7_a204_472d_8ed4_4096a3961e2d
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5330
is: SBO:0000252
name: PLCB2
initial amount: NaN
has only substance units: false
constant: false
is: Q59F77
type: Species

metaM debrisoquine c
is: CHEBI:34665
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C10H14N3 CHARGE: 1 INCHI: InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12)
name: debrisoquine
is: SBO:0000247
is: HMDB06543
type: Species
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_7b1416bd_3cb5_4af6_a80f_07404aee94ed
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23169
initial amount: NaN
is: Q9NTN3
has only substance units: false
constant: false
name: SLC35D1

metaR D3AIBTm
fast: false
type: Reaction
reactant: MODEL1310110013#
is: SBO:0000176
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
kinetic law: MODEL1310110013#
reversible: true
is described by: ECO:0000000

metaR CORE6GTg
product: MODEL1310110013#
reactant: MODEL1310110013#
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
modifier: MODEL1310110013#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_9d2239f9_510f_480f_afca_95eabc0b71a1
has only substance units: false
initial amount: NaN
is encoded by: hsa:490
is: P20020
name: ATP2B1
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110013#_c9c47f21_1df6_4b1e_971e_fb1397021c88
type: Species
initial concentration: NaN
is: Q9UBF8
initial amount: NaN
is encoded by: hsa:5298
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: PI4KB

metaR r0812
reactant: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.41
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR r2519
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
is: SBO:0000185
name: Utilized transport
fast: false
reactant: MODEL1310110013#
reversible: true
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
type: Reaction

metaM glx m
has only substance units: false
boundary condition: false
is: CHEBI:36655
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
name: glyoxylate
type: Species
is: HMDB00119

metaR EX 3aib D LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-3-Amino-isobutanoate exchange
type: Reaction

metaM HC01434 m
is: CHEBI:58931
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)

metaR LINKDEG1ly
type: Reaction
reactant: MODEL1310110013#
fast: false
is: SBO:0000176
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
reversible: false

metaR 34HPPte
is described by: ECO:0000134
reactant: MODEL1310110013#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
kinetic law: MODEL1310110013#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_c97d6d3f_c186_44ba_9558_7b42cd3821a9
is: Q0VAA5
has only substance units: false
boundary condition: true
name: PLCXD2
is: SBO:0000252
is encoded by: hsa:257068
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR ATP1ter
reactant: MODEL1310110013#
name: ADP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110013#
product: MODEL1310110013#
reversible: true

metaM lnlncg c
type: Species
name: gamma-linolenate
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
has only substance units: false
is: CHEBI:32391
initial amount: NaN
is: HMDB03073
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR UDPGLCter
product: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is: SBO:0000185
kinetic law: MODEL1310110013#
fast: false
is described by: ECO:0000000
type: Reaction

metaR RE1525M
name: RE1525
product: MODEL1310110013#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

metaM fadh2 m
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
constant: false
initial amount: NaN
name: Flavin adenine dinucleotide reduced
has only substance units: false
is: HMDB01197
type: Species
is: C01352
initial concentration: 1.0
is: CHEBI:58307
is: SBO:0000247
boundary condition: false

metaM HC01401 m
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:27668
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR FALDH
reversible: true
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
modifier: MODEL1310110013#
is described by: ECO:0000269
name: formaldehyde dehydrogenase
type: Reaction

metaM HC02208 c
boundary condition: false
initial amount: NaN
name: prostaglandin-d1
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
constant: false
has only substance units: false
is: CHEBI:27696
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_5c80310c_fbfc_4de5_9fcc_e58b9e580b14
type: Species
is encoded by: hsa:280
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P19961
name: AMY2B
constant: false
boundary condition: true
initial amount: NaN

metaR r0539
type: Reaction
reversible: true
product: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.1.1.34
reactant: MODEL1310110013#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
kinetic law: MODEL1310110013#
is: SBO:0000176

metaR LNLCCRNt
reversible: false
is described by: ECO:0000269
fast: false
reactant: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
name: transport into the mitochondria (carnitine)

metaR DGTPtm
kinetic law: MODEL1310110013#
fast: false
product: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
reversible: false
is described by: ECO:0000134
is: SBO:0000185
name: transport of dGTP into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR r2139
reactant: MODEL1310110013#
product: MODEL1310110013#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110013#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR r2408
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110013#
reversible: false
product: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
fast: false
kinetic law: MODEL1310110013#

metaR H2O2t
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is: SBO:0000185
type: Reaction
name: hydrogen peroxide transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
reactant: MODEL1310110013#
reversible: true
product: MODEL1310110013#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110013#_7065a3b8_61c9_4b68_8be3_4a8fe901985f
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: P51178
is encoded by: hsa:5333
initial amount: NaN
name: PLCD1
has only substance units: false

metaR q10h2tc
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
kinetic law: MODEL1310110013#
is: SBO:0000185
fast: false
name: transport of ubiquinol into cytosol
is described by: ECO:0000134

metaR TETPENT3t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
name: fatty acid transport via diffusion
reversible: true
type: Reaction
reactant: MODEL1310110013#
product: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
fast: false

metaR r0744
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
fast: false
product: MODEL1310110013#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110013#
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107

metaM nadp r
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate
initial amount: NaN
is: C00006
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006

http://identifiers.org/biomodels.db/MODEL1310110013#_daaa1f26_d6c1_48d8_9151_ead999a26cb7
name: SCD5
is: SBO:0000252
boundary condition: true
constant: false
is: Q86SK9
has only substance units: false
initial amount: NaN
is encoded by: hsa:79966
initial concentration: NaN
type: Species

metaR r2516
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
fast: false
kinetic law: MODEL1310110013#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110013#
reversible: true
type: Reaction
reactant: MODEL1310110013#

metaR GLXtm
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: glyoxylate transport, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110013#
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_0e60c54d_46b6_4d5c_812c_6bb4c5d2d8b2
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AL038231
initial amount: NaN
name: _AL038231_1_c
boundary condition: true
is: SBO:0000252
type: Species

metaR r1589
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110013#
product: MODEL1310110013#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110013#

metaR GTHPm
type: Reaction
product: MODEL1310110013#
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
reactant: MODEL1310110013#
name: glutathione peroxidase, mitochondria
kinetic law: MODEL1310110013#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110013#_0c95f4ba_72f1_4486_ab85_bd894e14140f
type: Species
is: O14521
constant: false
has only substance units: false
name: SDHD
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6392
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_1574cc1d_fc75_418f_b881_7a4fb4f81ec2
name: SLC8A1
is encoded by: hsa:6546
constant: false
is: F6VPY9
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaM adrn c
is: SBO:0000247
type: Species
is: CHEBI:53487
initial amount: NaN
is: HMDB02226
name: adrenic acid
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110013#_6ce9cc52_637a_4827_92af_633977295140
is: P17858
type: Species
initial concentration: NaN
constant: false
name: PFKL
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5211
is: SBO:0000252

metaM arachcrn c
is: HMDB06460
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: arachidyl carnitine
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial amount: NaN
is: SBO:0000247
constant: false

metaR r0743
reactant: MODEL1310110013#
is described by: ECO:0000000
kinetic law: MODEL1310110013#
is: SBO:0000176
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reversible: false
fast: false
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
modifier: MODEL1310110013#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:

metaM 6a2ohxnt x
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
type: Species
has only substance units: false
is: CHEBI:17534
is: HMDB12151
initial concentration: 1.0
is: SBO:0000247
name: 6-amino-2-oxohexanoic acid

metaM HC01401 x
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
is: CHEBI:27668
has only substance units: false

metaR UGALGTg
reactant: MODEL1310110013#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
is described by: ECO:0000134
is: SBO:0000176
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
modifier: MODEL1310110013#
reversible: false
product: MODEL1310110013#
kinetic law: MODEL1310110013#

metaM sarcs c
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:3513
type: Species
is: C00213
is: SBO:0000247
boundary condition: false
name: Sarcosine
is: HMDB00271
notes: FORMULA: C3H7NO2 CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110013#_3db60e85_473c_4a9b_a481_527e5c6b2c37
is: P36969
initial concentration: NaN
is encoded by: hsa:2879
name: GPX4
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_1fbc9708_3b34_4f4f_b1f0_944054e6cc56
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q16850
is encoded by: hsa:1595
has only substance units: false
type: Species
boundary condition: true
name: CYP51A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_ae7e91de_fb87_41b4_b295_f07d0b0d61d6
type: Species
is encoded by: hsa:D87002
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _D87002_1_m
initial amount: NaN

metaM damp c
is: HMDB00905
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58245
type: Species
name: dAMP(2-)
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
initial amount: NaN

metaR S3TASE1ly
reactant: MODEL1310110013#
reversible: true
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110013#
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110013#_80a642ec_f94c_43e9_b81f_f3d428b80986
name: ZADH2
boundary condition: true
type: Species
constant: false
is: Q8N4Q0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:284273
has only substance units: false

metaR r2137
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110013#

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaM cspg b e
is: CHEBI:16040
is: HMDB00630
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C45H65N2O48S4X CHARGE: -6

http://identifiers.org/biomodels.db/MODEL1310110013#_a9a3bbe0_e148_4a1a_8845_8ede884e5f96
has only substance units: false
constant: false
is encoded by: hsa:6390
name: SDHB
boundary condition: true
is: P21912
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_10b6381b_25df_4ceb_9d45_48d07cff8fe4
boundary condition: true
type: Species
constant: false
is: P24539
is encoded by: hsa:515
name: ATP5F1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR r2518
reactant: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
product: MODEL1310110013#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
fast: false

metaM HC02121 c
has only substance units: false
initial amount: NaN
name: S-(hydroxymethyl)glutathione(1-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
type: Species
is: CHEBI:58758
constant: false

metaR GCALDD
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
reactant: MODEL1310110013#
reversible: false
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR

metaM gd3 hs g
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:28424
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
name: GD3

metaM dcdp n
name: dCDP(3-)
is: CHEBI:58593
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

metaR 3MOPt2im
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110013#
reactant: MODEL1310110013#
type: Reaction
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
kinetic law: MODEL1310110013#
is: SBO:0000185

metaM fadh2 r
constant: false
is: HMDB01197
type: Species
boundary condition: false
is: CHEBI:58307
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
initial concentration: 1.0
is: SBO:0000247

metaM dgsn m
initial amount: NaN
boundary condition: false
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Deoxyguanosine
has only substance units: false
is: CHEBI:17172
type: Species

metaR r1587
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
reversible: true

metaR r2136
is: SBO:0000185
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
reversible: false
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_cece934b_ced2_4694_ae6e_3ecc3a009491
is encoded by: hsa:1350
initial concentration: NaN
is: P15954
name: COX7C
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r0093
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.3
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
is: SBO:0000176
modifier: MODEL1310110013#
product: MODEL1310110013#

metaR Htx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
type: Reaction
is described by: ECO:0000000
name: H transporter, peroxisome
reactant: MODEL1310110013#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110013#
reversible: true
product: MODEL1310110013#

metaR r2517
product: MODEL1310110013#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110013#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
kinetic law: MODEL1310110013#

metaR RE0383C
product: MODEL1310110013#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2
name: RE0383
reactant: MODEL1310110013#
modifier: MODEL1310110013#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
type: Reaction

metaM sarcs e
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:15611
name: sarcosine
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: HMDB00271

http://identifiers.org/biomodels.db/MODEL1310110013#_968c61ed_bf0d_4619_83ba_3f40a3020c46
is: Q13057
has only substance units: false
type: Species
initial amount: NaN
name: COASY
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80347
constant: false

metaR MI1PP
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.25
product: MODEL1310110013#
name: myo-inositol 1-phosphatase
modifier: MODEL1310110013#
reversible: false
is: SBO:0000176

metaR r1588
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110013#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110013#
reversible: true
fast: false
kinetic law: MODEL1310110013#

metaM dcdp m
is: SBO:0000247
initial concentration: 1.0
is: HMDB01245
name: dCDP(3-)
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593

http://identifiers.org/biomodels.db/MODEL1310110013#_3c632b36_ddb7_408e_91c8_4c47fbedf07c
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is: P21953
type: Species
name: BCKDHB
is encoded by: hsa:594
has only substance units: false
initial amount: NaN

metaR r0741
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000
product: MODEL1310110013#
reversible: true
is: SBO:0000176
modifier: MODEL1310110013#
kinetic law: MODEL1310110013#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
reactant: MODEL1310110013#
type: Reaction

metaR HACD1m
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
product: MODEL1310110013#
fast: false
reversible: true
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_9b14aede_8033_4336_93b0_f5da890525e8
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
name: NDUFS5
is: Q6IBA0
is encoded by: hsa:4725
initial amount: NaN

metaM pail5p hs n
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaR ARACHDCOAtx
name: fatty acid intracellular transport
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110013#
product: MODEL1310110013#
kinetic law: MODEL1310110013#

metaR MI1PS
is described by: ECO:0000269
kinetic law: MODEL1310110013#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/5.5.1.4
is: SBO:0000176
product: MODEL1310110013#
modifier: MODEL1310110013#
type: Reaction
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
name: myo-Inositol-1-phosphate synthase

http://identifiers.org/biomodels.db/MODEL1310110013#_cd3f5086_cd71_47b8_85d9_2e90ae485c12
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9963
has only substance units: false
name: SLC23A1
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110013#_cc4b6f30_e879_4a72_afeb_91094319981d
constant: false
is encoded by: hsa:6549
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9UBY0
name: SLC9A2
has only substance units: false
type: Species

metaR biomass reaction
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
reversible: false
fast: false
name: biomass_reaction
product: MODEL1310110013#

metaR FADH2tx
fast: false
reversible: true
product: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
is: SBO:0000185
reactant: MODEL1310110013#
is described by: ECO:0000000
type: Reaction
name: FADH2 transporter, peroxisomal
kinetic law: MODEL1310110013#

metaM coumarin c
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C9H6O2 CHARGE: 0 INCHI: InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
has only substance units: false
name: coumarin
boundary condition: false
is: SBO:0000247
is: CHEBI:28794
constant: false
is: HMDB01218

metaR BAAT2x
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
modifier: MODEL1310110013#
name: bile acid Coenzyme A: amino acid N-acyltransferase
type: Reaction
kinetic law: MODEL1310110013#
fast: false
reactant: MODEL1310110013#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110013#
is described by: ECO:0000269

metaR FAOXC1811603m
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/1.3.8.1
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000269
reactant: MODEL1310110013#

metaR r2512
type: Reaction
name: Utilized transport
reactant: MODEL1310110013#
is described by: ECO:0000000
product: MODEL1310110013#
is: SBO:0000185
kinetic law: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false

metaM cspg b l
constant: false
notes: FORMULA: C45H65N2O48S4X CHARGE: -6
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan
is: HMDB02183
initial concentration: 1.0
boundary condition: false
is: CHEBI:36005

metaM ksii core2 deg6 l
is: HMDB00143
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:12936
notes: FORMULA: C44H72N4O33SX CHARGE: -1
type: Species
boundary condition: false
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 6
initial concentration: 1.0

metaR H7 TAer
is described by: ECO:0000000
product: MODEL1310110013#
kinetic law: MODEL1310110013#
name: H7' transamidase, endoplasmic reticulum
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110013#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD

http://identifiers.org/biomodels.db/MODEL1310110013#_795f49bb_af81_4b53_833a_99fc1ff72fb0
is: P42336
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5290
is: SBO:0000252
name: PIK3CA
boundary condition: true
has only substance units: false
constant: false

metaR r1585
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110013#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110013#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR GLXtp
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110013#
name: glyoxylate transport, peroxisomal
product: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
type: Reaction
reversible: true

metaR NAt3 1
fast: false
is: SBO:0000185
product: MODEL1310110013#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
is described by: ECO:0000269
reversible: true
type: Reaction
modifier: MODEL1310110013#
reactant: MODEL1310110013#
name: sodium proton antiporter (H:NA is 1:1)
kinetic law: MODEL1310110013#

metaM dadp c
name: dADP
initial concentration: 1.0
initial amount: NaN
is: C00206
constant: false
type: Species
boundary condition: false
is: CHEBI:57667
has only substance units: false
is: HMDB01508
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110013#_6cf4d1c9_de4a_4b95_bf01_88126ab2caab
initial concentration: NaN
has only substance units: false
name: SLC23A2
is encoded by: hsa:9962
is: Q9UGH3
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110013#_5c29aabb_acf3_4982_9721_cdc82b018691
has only substance units: false
name: ALG12
is: SBO:0000252
type: Species
boundary condition: true
is: Q9BV10
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:79087
constant: false

metaR r0747
is described by: ECO:0000000
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
reactant: MODEL1310110013#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
product: MODEL1310110013#
reversible: true
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false

metaR 34DHPHEt
modifier: MODEL1310110013#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD
product: MODEL1310110013#
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
reversible: true
is described by: ECO:0000269
name: 3,4-Dihydroxy-L-phenylalanine transport

metaR r2133
reversible: true
kinetic law: MODEL1310110013#
modifier: MODEL1310110013#
is described by: ECO:0000000
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction

metaM ksii core4 deg3 l
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
is: CHEBI:12936
is: HMDB00143
constant: false
initial amount: NaN
type: Species
name: keratan sulfate II (core 4-linked), degradation product 3
boundary condition: false
has only substance units: false

metaR r2511
name: Utilized transport
reactant: MODEL1310110013#
product: MODEL1310110013#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
fast: false
is described by: ECO:0000000

metaM octa c
notes: FORMULA: C8H15O2 CHARGE: -1
is: HMDB00482
is: SBO:0000247
is: CHEBI:25646
name: octanoate (n-C8:0)
initial amount: NaN
boundary condition: false
type: Species
is: C06423
has only substance units: false
constant: false
initial concentration: 1.0

metaM cmpacna c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false
is: CHEBI:57812
initial amount: NaN
type: Species
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false

metaM etoh c
boundary condition: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
constant: false
is: CHEBI:16236
is: SBO:0000247
type: Species
is: HMDB00108
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: ethanol

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR r1586
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110013#

http://identifiers.org/biomodels.db/MODEL1310110013#_8b3523d7_9aeb_40d6_bcdf_21f3b02e7b57
name: DLAT
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:1737
is: Q86YI5
initial concentration: NaN

metaR r0819
reversible: true
product: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
reactant: MODEL1310110013#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110013#
fast: false
modifier: MODEL1310110013#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110013#_f147d5a7_35a9_4c98_a757_ba73d712b250
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7108
constant: false
name: TM7SF2
initial amount: NaN
initial concentration: NaN
is: O76062

metaM acngalgbside hs g
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB03406
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16523
name: sialyl galactosylgloboside

metaM dlnlcgcoa r
is: CHEBI:27979
initial amount: NaN
is: C03595
name: dihomo-gamma-linolenyl coenzyme A
constant: false
has only substance units: false
type: Species
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r2514
kinetic law: MODEL1310110013#
name: Utilized transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110013#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110013#

metaM ddcacoa m
name: Dodecanoyl-CoA (n-C12:0CoA)
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57375
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB03571
is: C01832

http://identifiers.org/biomodels.db/MODEL1310110013#_9c5ff970_6edf_40cf_b5aa_31ac0280dfa8
constant: false
has only substance units: false
boundary condition: true
name: SLC26A1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:10861

metaM pan4p m
is: CHEBI:47942
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
name: pantetheine 4'-phosphate(2-)
is: HMDB01416

metaR Htr
type: Reaction
kinetic law: MODEL1310110013#
reversible: true
fast: false
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
product: MODEL1310110013#
name: H transporter, endoplasmic reticulum
is: SBO:0000185

metaR r2132
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110013#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110013#
type: Reaction
product: MODEL1310110013#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110013#

metaR DLNLCGt
product: MODEL1310110013#
name: fatty acid transport via diffusion
reversible: true
is: SBO:0000185
reactant: MODEL1310110013#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110013#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaR r1583
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110013#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110013#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110013#

metaR PA HStg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
reversible: true
kinetic law: MODEL1310110013#
reactant: MODEL1310110013#
product: MODEL1310110013#
fast: false
type: Reaction
is described by: ECO:0000000
name: phosphatidate scramblase
is: SBO:0000185

metaR r0818
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110013#
kinetic law: MODEL1310110013#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
name: Transport reaction
type: Reaction
reversible: false
product: MODEL1310110013#

metaR RE3218C
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110013#
reactant: MODEL1310110013#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
kinetic law: MODEL1310110013#
is version of: http://identifiers.org/ec-code/3.1.6.2
product: MODEL1310110013#
fast: false
name: RE3218

http://identifiers.org/biomodels.db/MODEL1310110013#_f198b497_bba0_4ee9_9c5b_6c312b920b6c
is: P25325
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: MPST
is encoded by: hsa:4357
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110013#_676867e5_7615_4619_ad5f_a2d92e0a3618
name: IDH2
constant: false
is: P48735
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:3418
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM cs a deg1 l
is: CHEBI:57455
is: HMDB01354
is: SBO:0000247
initial concentration: 1.0
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
initial amount: NaN
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
has only substance units: false
constant: false
boundary condition: false